NIH PA · NIH · R01
PA-25-305: NIH Research Project Grant (Parent R01 Clinical Trial Required)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). This Parent Notice of Funding Opportunity Announcement requires that at lease 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.
- NOFO number
- PA-25-305
- Type
- PA
- Activity code
- R01
- Primary institute
- NIH
- Clinical trials
- Required
- Posted
- Dec 18, 2024
- Opens
- Jan 5, 2025
- Expires
- Jan 8, 2028
PA-25-305 due dates
3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 05, 2025 | March 05, 2025 * | May 07, 2025 * | July 2025 | October 2025 | December 2025 |
| June 05, 2025 | July 05, 2025 * | September 07, 2025 * | November 2025 | January 2026 | April 2026 |
| October 05, 2025 | November 05, 2025 * | January 07, 2026 * | March 2026 | May 2026 | July 2026 |
| February 05, 2026 | March 05, 2026 * | May 07, 2026 * | July 2026 | October 2026 | December 2026 |
| June 05, 2026 | July 05, 2026 * | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 05, 2026 | November 05, 2026 * | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 05, 2027 | March 05, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
| June 05, 2027 | July 05, 2027 * | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 05, 2027 | November 05, 2027 * | Not Applicable | March 2028 | May 2028 | July 2028 |
Projects funded under PA-25-305
NIH RePORTER lists 354 projects funded under PA-25-305 in FY2022–FY2026, with $277.9M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
354
Distinct projects, FY2022–FY2026
New awards
327
Type 1 (new project) award records
NIH funding
$277.9M
Award dollars under PA-25-305, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 1 | 1 | $680K |
| FY2026 | 356 | 326 | $277.2M |
Institutions with the most funding
- University of Michigan at Ann Arbor$9.9M · 14 projects
- University of Washington$9.3M · 12 projects
- University of Southern California$9.0M · 3 projects
- Johns Hopkins University$7.6M · 10 projects
- New York University School of Medicine$7.2M · 8 projects
- University of Virginia$6.9M · 9 projects
- University of California Los Angeles$6.9M · 8 projects
- University of Colorado Denver$5.8M · 8 projects
Most recent new awards
- Central mechanisms of nausea and their modulation via non-invasive neurostimulation (opens NIH RePORTER)
Spaulding Rehabilitation Hospital · 1R01AT014133-01 · NCCIH · Notice Sep 24, 2026
$553KR01
- Testing the "Stigma Reduction Logic Model Plus" (SRLM+): A Structural Approach to Addressing HIV-related Stigma in Healthcare Settings (opens NIH RePORTER)
New York State Psychiatric Institute DBA Research Foundation for Mental Hygiene, Inc · 1R01AI207137-01 · NIAID · Notice Sep 22, 2026
$741KR01
- Empowering Parents of Critically Ill Children: A Multi-Site Evaluation of the EMPOWER-PICU Intervention (opens NIH RePORTER)
Weill Medical Coll of Cornell Univ · 1R01NR022612-01A1 · NINR · Notice Sep 19, 2026
$804KR01
- Evaluation of a community co-developed intervention focused on quality of life in Spanish-speaking families impacted by childhood cancer (opens NIH RePORTER)
University of California-Irvine · 1R01NR022176-01A1 · NINR · Notice Sep 18, 2026
$801KR01
- Mechanistic Evaluation of Psilocybin in Opioid Use Disorder: A Randomized, Double-Blind, Active-Placebo-Controlled Crossover Trial with Pharmacokinetic/Pharmacodynamic Modeling (opens NIH RePORTER)
Johns Hopkins University · 1R01DA066503-01 · NIDA · Notice Sep 18, 2026
$684KR01
- HIV Testing and Communication skills training to reduce HIV risk and Improve PREP uptake (opens NIH RePORTER)
Hunter College · 1R01AI207135-01A1 · NIAID · Notice Sep 18, 2026
$812KR01
What its predecessor PA-20-183 funded
PA-25-305 reissues PA-20-183. Its funding history is the best guide to who wins under this program: 1,206 projects and $2.74B in FY2022–FY2026.
Projects funded
1,206
Distinct projects, FY2022–FY2026
New awards
972
Type 1 (new project) award records
NIH funding
$2.74B
Award dollars under PA-20-183, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 421 | 271 | $285.7M |
| FY2023 | 681 | 261 | $447.9M |
| FY2024 | 923 | 226 | $609.7M |
| FY2025 | 1,179 | 192 | $755.0M |
| FY2026 | 1,045 | 22 | $642.3M |
Institutions with the most funding
- University of California, San Francisco$77.5M · 35 projects
- Johns Hopkins University$77.3M · 34 projects
- Massachusetts General Hospital$75.1M · 33 projects
- Vanderbilt University Medical Center$70.6M · 21 projects
- University of Pittsburgh at Pittsburgh$70.3M · 34 projects
- Yale University$70.2M · 30 projects
- University of Michigan at Ann Arbor$68.2M · 34 projects
- University of Pennsylvania$64.6M · 29 projects
Most recent new awards
- Type 1 Hybrid Study of For You, For Me, For Us (opens NIH RePORTER)
Florida International University · 1R01MH140715-01 · NIMH · Notice Sep 16, 2026
$460KR01
- Wearable focal vibration on mobility and pain in patients with diabetic peripheral neuropathy (opens NIH RePORTER)
University of Florida · 1R01DK141800-01A1 · NIDDK · Notice Sep 3, 2026
$1.5MR01
- Resistance exercise training for older adults with obesity using GLP- receptor agonists (opens NIH RePORTER)
University of Florida · 1R01AG094959-01 · NIA · Notice Aug 31, 2026
$726KR01
- Problem solving therapy to improve CMD and HIV care outcomes for PWH on ART in Vietnam: a randomized controlled trial (opens NIH RePORTER)
Univ of North Carolina Chapel Hill · 1R01MH136958-01A1 · NIMH · Notice Aug 10, 2026
$705KR01
- Phenotyping risk for obesity in middle childhood (opens NIH RePORTER)
Pennsylvania State University, the · 1R01DK144201-01 · NIDDK · Notice Jul 10, 2026
$753KR01
- ¡GANAS!: A Men’s Health Intervention to Improve Sleep, Increase Social Connectedness and Reduce Stress Among Low-Income Men (opens NIH RePORTER)
Drexel University · 1R01MD019685-01A1 · NIMHD · Notice Jul 10, 2026
$781KR01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
22 NIH institutes and offices take applications under PA-25-305. Contact the program officer at the institute that fits your research before applying.
- NIH
- NEI · National Eye Institute
- NHLBI · National Heart, Lung, and Blood Institute
- NHGRI · National Human Genome Research Institute
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NIAID · National Institute of Allergy and Infectious Diseases
- NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
- NIBIB · National Institute of Biomedical Imaging and Bioengineering
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCD · National Institute on Deafness and Other Communication Disorders
- NIDDK · National Institute of Diabetes and Digestive and Kidney Diseases
- NIDA · National Institute on Drug Abuse
- NIEHS · National Institute of Environmental Health Sciences
- NIGMS · National Institute of General Medical Sciences
- NIMH · National Institute of Mental Health
- NINDS · National Institute of Neurological Disorders and Stroke
- NINR · National Institute of Nursing Research
- NIMHD · National Institute on Minority Health and Health Disparities
- NLM · National Library of Medicine
- NCCIH · National Center for Complementary and Integrative Health
- NCI · National Cancer Institute
Related notices
Jan 28, 2026 · NOT-OD-26-029
NIH Removing AIDS Application Due Dates from NOFOs. See Notice NOT-OD-26-029.
Mar 25, 2026 · NOT-CA-26-009
Notice of National Cancer Institute's Participation in PA-25-305, NIH Research Project Grant Parent R01 Clinical Trial Required).
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Notices of Special Interest (NOSIs)
NIH has attached 101 NOSIs to PA-25-305; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.
Award terms
- Application types allowed
- NewRenewalResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited but need to reflect the actual needs of the proposed project.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PA-20-183.
- Companion NOFOs: PA-25-301, PA-25-303.
Other open NOFOs for R01
- PA-25-301NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)NIH · next due Feb 5, 2027
- PAR-25-077CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Basic Research on Chemical Threats that Affect the Nervous System (R01 Clinical Trial Not Allowed)NINDS · next due Oct 16, 2026
- PAR-25-371Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)NHGRI · next due Oct 20, 2026
- PAR-25-271NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required)NCCIH · next due Oct 20, 2026
- PAR-25-267NCCIH Multi-Site Feasibility Clinical Trials of Mind and Body Interventions (R01 Clinical Trial Required)NCCIH · next due Oct 20, 2026
- PAR-25-268Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)NCCIH · next due Oct 20, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.