NIH PA · NIH · R01
PA-25-301: NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions. This Notice of Funding Opportunity does not accept applications proposing clinical trial(s).
- NOFO number
- PA-25-301
- Type
- PA
- Activity code
- R01
- Primary institute
- NIH
- Clinical trials
- Not Allowed
- Posted
- Dec 18, 2024
- Opens
- Jan 5, 2025
- Expires
- Jan 8, 2028
PA-25-301 due dates
3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 05, 2025 | March 05, 2025 * | May 07, 2025 * | July 2025 | October 2025 | December 2025 |
| June 05, 2025 | July 05, 2025 * | September 07, 2025 * | November 2025 | January 2026 | April 2026 |
| October 05, 2025 | November 05, 2025 * | January 07, 2026 * | March 2026 | May 2026 | July 2026 |
| February 05, 2026 | March 05, 2026 * | May 07, 2026 * | July 2026 | October 2026 | December 2026 |
| June 05, 2026 | July 05, 2026 * | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 05, 2026 | November 05, 2026 * | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 05, 2027 | March 05, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
| June 05, 2027 | July 05, 2027 * | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 05, 2027 | November 05, 2027 * | Not Applicable | March 2028 | May 2028 | July 2028 |
Projects funded under PA-25-301
NIH RePORTER lists 4,457 projects funded under PA-25-301 in FY2022–FY2026, with $3.51B in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
4,457
Distinct projects, FY2022–FY2026
New awards
3,726
Type 1 (new project) award records
NIH funding
$3.51B
Award dollars under PA-25-301, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 7 | 4 | $7.9M |
| FY2026 | 4,508 | 3,722 | $3.51B |
Institutions with the most funding
- University of Pennsylvania$88.3M · 116 projects
- Massachusetts General Hospital$80.7M · 94 projects
- University of California, San Francisco$78.3M · 100 projects
- Stanford University$74.1M · 90 projects
- Duke University$71.6M · 86 projects
- Johns Hopkins University$70.1M · 97 projects
- University of Michigan at Ann Arbor$67.5M · 98 projects
- Washington University$67.4M · 93 projects
Most recent new awards
- Quantifying Pollen Allergens with DNA Metabarcoding (opens NIH RePORTER)
University of Washington · 1R01AI204107-01 · NIAID · Notice Sep 30, 2026
$379KR01
- Developing Integration and Modeling Frameworks for Single-Cell and Bulk Transcriptomics to Analyze Atlas-Scale Cell-Resolved Immune Variation Across Infections and Vaccinations (opens NIH RePORTER)
Yale University · 1R01AI198335-01A1 · NIAID · Notice Sep 29, 2026
$570KR01
- Stem- and Paneth cell-specific CD74 functions control gut immune responses (opens NIH RePORTER)
Rutgers Biomedical and Health Sciences · 1R01DK148717-01 · NIDDK · Notice Sep 29, 2026
$780KR01
- Macrophage interactions underlying adult testicular function (opens NIH RePORTER)
Cincinnati Childrens Hosp Med Ctr · 1R01HD124040-01 · NICHD · Notice Sep 28, 2026
$705KR01
- Understanding the Roles of Synovitis, Knee-Adjacent Obesity and Sarcopenia in Pain Phenotypes and Structural Progression of Knee Osteoarthritis - An Analysis of the Entire Osteoarthritis Initiative (opens NIH RePORTER)
University of California, San Francisco · 1R56AR085666-01A1 · NIAMS · Notice Sep 23, 2026
$621KR56
- Regulated, Long-Term Expression of Anti-HIV Antibodies via B Cell Receptor-Targeted Lentiviral Transduction (opens NIH RePORTER)
University of California Los Angeles · 1R01AI200582-01A1 · NIAID · Notice Sep 23, 2026
$5.9MR01
What its predecessor PA-20-185 funded
PA-25-301 reissues PA-20-185. Its funding history is the best guide to who wins under this program: 20,165 projects and $38.40B in FY2022–FY2026.
Projects funded
20,165
Distinct projects, FY2022–FY2026
New awards
13,449
Type 1 (new project) award records
NIH funding
$38.40B
Award dollars under PA-20-185, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 7,683 | 3,702 | $4.22B |
| FY2023 | 11,938 | 3,709 | $6.53B |
| FY2024 | 15,770 | 3,290 | $8.56B |
| FY2025 | 17,898 | 2,611 | $10.84B |
| FY2026 | 14,066 | 137 | $8.24B |
Institutions with the most funding
- University of Michigan at Ann Arbor$928.5M · 501 projects
- University of California, San Francisco$890.1M · 422 projects
- University of Pennsylvania$877.5M · 469 projects
- Washington University$861.2M · 472 projects
- University of Pittsburgh at Pittsburgh$845.7M · 437 projects
- Yale University$786.1M · 405 projects
- Columbia University Health Sciences$770.7M · 383 projects
- Johns Hopkins University$741.9M · 400 projects
Most recent new awards
- Specialized metabolites of medicinal and poisonous insect pathogenic fungi (opens NIH RePORTER)
Utah State Higher Education System--University of Utah · 1R01AT013242-01 · NCCIH · Notice Sep 18, 2026
$615KR01
- Characterizing a Calcium Channel Causing FASP: Examining Entrainment Changes as a Mechanism for Phase Advance (opens NIH RePORTER)
University of California, San Francisco · 1R56NS144190-01 · NINDS · Notice Sep 17, 2026
$574KR56
- Alleviating antibiotic-induced microbiome dysfunction by quenching the microbial redox environment (opens NIH RePORTER)
Brown University · 1R01AT013053-01A1 · NCCIH · Notice Sep 16, 2026
$577KR01
- Mechanisms of Aldehyde-Driven Metabolic Dysfunction-Associated Steatohepatitis (opens NIH RePORTER)
Medical University of South Carolina · 1R01AT013393-01 · NCCIH · Notice Sep 16, 2026
$641KR01
- Enhancing early detection and intervention for cognitive decline through FHIR-based clinical decision support (opens NIH RePORTER)
Brigham and Women's Hospital · 1R01AG094807-01 · NIA · Notice Sep 16, 2026
$743KR01
- Blood-based genomics, transcriptomics, and immune responses in early-onset AD (opens NIH RePORTER)
University of California, San Francisco · 1R01AG096763-01 · NIA · Notice Sep 9, 2026
$709KR01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
25 NIH institutes and offices take applications under PA-25-301. Contact the program officer at the institute that fits your research before applying.
- NIH
- NEI · National Eye Institute
- NHLBI · National Heart, Lung, and Blood Institute
- NHGRI · National Human Genome Research Institute
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NIAID · National Institute of Allergy and Infectious Diseases
- NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
- NIBIB · National Institute of Biomedical Imaging and Bioengineering
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCR · National Institute of Dental and Craniofacial Research
- NIDDK · National Institute of Diabetes and Digestive and Kidney Diseases
- NIDA · National Institute on Drug Abuse
- NIEHS · National Institute of Environmental Health Sciences
- NIGMS · National Institute of General Medical Sciences
- NIMH · National Institute of Mental Health
- NINDS · National Institute of Neurological Disorders and Stroke
- NINR · National Institute of Nursing Research
- NIDCD · National Institute on Deafness and Other Communication Disorders
- NIMHD · National Institute on Minority Health and Health Disparities
- NLM · National Library of Medicine
- NCCIH · National Center for Complementary and Integrative Health
- ORIP
- NCI · National Cancer Institute
- NCATS · National Center for Advancing Translational Sciences
Related notices
May 27, 2026 · NOT-TR-26-007
Notice of NCATS Participation in Notice of Funding Opportunity NOFO) PA-25-301 NIH Research Project Grant Parent R01 Clinical Trial Not Allowed).
Jan 28, 2026 · NOT-OD-26-029
NIH Removing AIDS Application Due Dates from NOFOs.
Mar 31, 2025
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.
Dec 19, 2024 · NOT-DC-25-022
Notice of NIDCD Participation in PA-25-301 NIH Research Project Grant Parent R01 Clinical Trial Not Allowed)". See Notice NOT-DC-25-022.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025.
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Notices of Special Interest (NOSIs)
NIH has attached 198 NOSIs to PA-25-301; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.
Award terms
- Application types allowed
- NewRenewalResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited but need to reflect the actual needs of the proposed project.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PA-20-185.
- Companion NOFOs: PA-25-303, PA-25-305.
Other open NOFOs for R01
- PA-25-305NIH Research Project Grant (Parent R01 Clinical Trial Required)NIH · next due Feb 5, 2027
- PAR-25-077CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Basic Research on Chemical Threats that Affect the Nervous System (R01 Clinical Trial Not Allowed)NINDS · next due Oct 16, 2026
- PAR-25-371Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)NHGRI · next due Oct 20, 2026
- PAR-25-271NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required)NCCIH · next due Oct 20, 2026
- PAR-25-267NCCIH Multi-Site Feasibility Clinical Trials of Mind and Body Interventions (R01 Clinical Trial Required)NCCIH · next due Oct 20, 2026
- PAR-25-268Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)NCCIH · next due Oct 20, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.