UU Series — Cooperative Agreements

NIH U01 Grants — Research Project — Cooperative Agreement

Reviewed by Dr. Meng ZhaoLast reviewed June 9, 2026Data refreshed September 5, 2026Editorial standards

Investigator-led research with NIH staff substantial involvement

Funding

R01-like; varies

Duration

3–5 years

Eligibility

Investigators on NIH-led initiatives

Activity code

U01

What is the NIH U01 grant?

The U01 is a cooperative agreement — similar in scope and funding to an R01, but with substantial involvement from NIH program staff. NIH staff participate in steering committees, scientific decisions, and milestone definitions. U01s are common for clinical trials, network science, and consortia where NIH-driven coordination matters.

Recent U01 awards from NIH RePORTER

Examples of funded U01 projects across the last two fiscal years. The matching-award count comes from the full result set; funding totals, averages, rankings, and examples use the first 500 records returned by NIH RePORTER. Figures reflect a snapshot last refreshed on September 5, 2026.

Matching awards (last 2 FYs)
3,447
Full matching record count on RePORTER
Sampled funding
$469.3M
Sum of award amounts in the sample
Average award
$939K
Mean award amount in the sample

Example U01 projects from the sample

  • mproving Access to Nephrology Treatment and Care among Patients at Greatest Risk for Kidney Failure

    5U01DK137269-04
    Kimberly Arriola · EMORY UNIVERSITY, GA · $762,917 · awarded Aug 28, 2026 · NIH

    Improving Access to Nephrology Treatment and Care among Patients at Greatest Risk for Kidney Failure Nearly 15% of U.S. adults have chronic kidney disease (CKD),1 yet because symptoms are often “silent,”2 only an estimated 12-19% are aware of their disease. A lack of a diagnosis results in substantial delays in accessing necessary care, such as referral to…

  • NAVIGATE Kidney: A Multi-Level Intervention to Reduce Kidney Health Disparities

    5U01DK137272-04
    Lilia Cervantes · UNIVERSITY OF COLORADO DENVER, CO · $764,433 · awarded Aug 28, 2026 · NIH

    Individuals experiencing progression from chronic kidney disease (CKD) to kidney failure face social challenges that contribute to kidney health disparities. Reducing the number of individuals who start KRT with a central venous catheter is critical because it is associated with a higher risk of fatal infection, non-fatal infection, hospitalization, and…

  • INSPIRE: INterventionS for Promoting kIdney tRansplant Empowerment

    5U01DK137259-04
    Lili Chan · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY · $836,530 · awarded Aug 28, 2026 · NIH

    (30 Lines) Modified Grant Title: INSPIRE: INterventionS for Promoting kIdney tRansplant Empowerment Kidney transplantation (KTx) is the preferred treatment for patients with end-stage kidney disease. Despite recent changes to the kidney allocation system some individuals are less likely to receive a KTx evaluation, a multi-step process requiring patient…

  • Clinical and mechanistic studies defining optimal preparative approaches to infants with IL2RG/JAK3/RAG1/RAG2 SCID: a randomized trial of busulfan dosage

    3U01AI184132-03S1
    JEFFERY AULETTA · NATIONAL MARROW DONOR PROGRAM, MN · $111,904 · awarded Aug 27, 2026 · NIH

    Project Summary Severe combined immunodeficiency (SCID) is a group of genetic disorders that abrogate T cell development and function. Allogeneic hematopoietic cell transplantation (HCT) is the standard treatment for the disease and can be performed successfully in SCID patients without the high dose pre-HCT busulfan conditioning due to the unique capacity…

  • Leveraging Prospective Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk Scores

    3U01CA261339-05S1
    Fei Chen · UNIVERSITY OF SOUTHERN CALIFORNIA, CA · $300,000 · awarded Aug 27, 2026 · NIH

    Abstract There are stark differences in the burden of certain cancers across populations. For example, in comparison to individuals of European ancestry, African American men have a ~67% higher incidence rate of prostate cancer and Asian/Pacific Islander men and women have a 70% and 95% higher incidence rate of liver cancer, respectively. These differences…

  • Discovery Science Collaborative for CKDu

    5U01DK130060-06
    VIVEK BHALLA · STANFORD UNIVERSITY, CA · $1,839,499 · awarded Aug 26, 2026 · NIH

    PROJECT SUMMARY / ABSTRACT The overall goal of the Discovery Science Collaborative for CKDu Renal Science Core is to bring the best investigative methods and scientific technology to the problem of CKDu. We will work closely with Field Epidemiology Sites, the Scientific Data Coordinating Center, NIDDK Leadership, the External Oversight Committee, and HHEAR…

  • Development of the anti-fentanyl monoclonal antibody, CSX-1004, for prophylaxis against fentanyl and fentanyl analog overdose

    5U01DA063352-02
    Andrew Barrett · CESSATION THERAPEUTICS, LLC, CA · $2,089,891 · awarded Aug 25, 2026 · NIH

    The opioid crisis in the United States has been dominated by illicitly manufactured fentanyl for a majority of the last decade, during which time over 400,000 Americans have died from unintentional overdose due to fentanyl or fentanyl analogs. The overdose reversal agent, naloxone, has been the cornerstone of opioid overdose management since 1971; however,…

  • Mechanistic clinical trial of blocking the IL-4/13 axis in asthmatics precision phenotyped in an aeroallergen challenge chamber before, during and after receipt of dupilumab

    3U01AI158460-05S1
    Sunil Ahuja · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX · $490,019 · awarded Aug 19, 2026 · NIH

    7. Project Summary/Abstract We propose a high-impact, randomized, double-blind, placebo-controlled, mechanistic clinical trial aimed at elucidating the basis for the wide heterogeneity in severity of and treatment responses in persons with allergic rhinoconjunctivitis (ARC) and allergic asthma (AA). AA and ARC are highly prevalent, environmentally triggered…

  • Mapping Neurocognitive Complications of Pediatric Type 1 Diabetes (T1D) and Potential Risk and Protective Factors

    5U01DK140764-03
    Aysenil Belger · UNIV OF NORTH CAROLINA CHAPEL HILL, NC · $559,495 · awarded Aug 19, 2026 · NIH

    Modified Project Summary/Abstract Section Type 1 diabetes (T1D) is associated with neurocognitive complications that may emerge early after diagnosis and worsen over time. Risk may be pronounced in children diagnosed prepubertally, as the developing brain is likely particularly vulnerable to dysglycemia, diabetic ketoacidosis (DKA), and other metabolic…

  • Development of a Novel Therapeutic for Mitigating Radiation-Induced Microbiome Dysbiosis and Acute Gastrointestinal Syndrome

    3U01AI172853-04S2
    Constantinos Broustas · COLUMBIA UNIVERSITY HEALTH SCIENCES, NY · $48,754 · awarded Aug 19, 2026 · NIH

    SUMMARY A mass casualty radiation event, such as the detonation of an improvised nuclear device or radiological dispersal device, could lead to severe hemorrhage, multi-organ failure, and infection, potentially leading to sepsis and/or death. The hematopoietic system and the gastrointestinal (GI) tract are among the most vulnerable tissues to radiation…

  • Bridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons

    5U01MH130907-05
    ANTON ARKHIPOV · ALLEN INSTITUTE, WA · $2,201,458 · awarded Aug 18, 2026 · NIH

    Bridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons The versatile and powerful functional properties of the brain are reflected in the neuronal activity patterns and computations, and their evolution over time due to learning, homeostatic plasticity, and other processes. The composition of brain circuits out of a large number of…

  • Clinical and mechanistic studies defining optimal preparative approaches to infants with IL2RG/JAK3/RAG1/RAG2 SCID: a randomized trial of busulfan dosage

    5U01AI184132-03
    JEFFERY AULETTA · NATIONAL MARROW DONOR PROGRAM, MN · $958,627 · awarded Aug 18, 2026 · NIH

    Project Summary Severe combined immunodeficiency (SCID) is a group of genetic disorders that abrogate T cell development and function. Allogeneic hematopoietic cell transplantation (HCT) is the standard treatment for the disease and can be performed successfully in SCID patients without the high dose pre-HCT busulfan conditioning due to the unique capacity…

Funding institutes in the sample

InstituteAwardsFunding
NIH457$445.8M
ALLCDC31$18.2M
FDA12$5.3M

Most frequent institutions in the sample

  1. VANDERBILT UNIVERSITY MEDICAL CENTER — 29 awards
  2. JOHNS HOPKINS UNIVERSITY — 20 awards
  3. UNIVERSITY OF CALIFORNIA, SAN DIEGO — 16 awards
  4. COLUMBIA UNIVERSITY HEALTH SCIENCES — 14 awards
  5. MASSACHUSETTS GENERAL HOSPITAL — 14 awards
  6. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — 12 awards
  7. UNIVERSITY OF MICHIGAN AT ANN ARBOR — 12 awards
  8. DUKE UNIVERSITY — 11 awards

Source: NIH RePORTER. Verify any award in the official record by searching its project number. See our data methodology for how this sample is built and its limitations.

Decision guide

Choose U01 when

Apply for U01 when an FOA you are responding to specifies the U01 mechanism, often because the program needs cross-site coordination.

Choose another mechanism when

For investigator-initiated work without NIH-led coordination, choose R01.

Who applies for U01

Investigators responding to U01 FOAs (which are typically more topic-specific than R01 PARs).

Compare nearby NIH grant mechanisms

Searchers often land on U01 while deciding between adjacent NIH activity codes. Compare scope, NIH staff involvement, budget scale, and applicant stage before choosing a funding opportunity.

For broad grant lookup, use the NIH grant search to find funded examples by activity code, PI, institution, and award year.

Search tips for U01

  • U01 awards anchor NIH consortia like the HEAL Initiative, RECOVER (long COVID), and the Cancer Moonshot.

Search NIH grants by activity code

Find U01-funded PIs

U01 funding trends

U01 frequently asked questions

What is the difference between R01 and U01?

R01 is investigator-initiated with minimal NIH involvement once funded. U01 is a cooperative agreement with substantial NIH program staff involvement (steering committees, milestones).

Related NIH grant types