NIH U01 Grants — Research Project — Cooperative Agreement
Reviewed by Dr. Meng ZhaoLast reviewed June 9, 2026Data refreshed September 5, 2026Editorial standards
Investigator-led research with NIH staff substantial involvement
Funding
R01-like; varies
Duration
3–5 years
Eligibility
Investigators on NIH-led initiatives
Activity code
U01
What is the NIH U01 grant?
The U01 is a cooperative agreement — similar in scope and funding to an R01, but with substantial involvement from NIH program staff. NIH staff participate in steering committees, scientific decisions, and milestone definitions. U01s are common for clinical trials, network science, and consortia where NIH-driven coordination matters.
Recent U01 awards from NIH RePORTER
Examples of funded U01 projects across the last two fiscal years. The matching-award count comes from the full result set; funding totals, averages, rankings, and examples use the first 500 records returned by NIH RePORTER. Figures reflect a snapshot last refreshed on September 5, 2026.
Example U01 projects from the sample
mproving Access to Nephrology Treatment and Care among Patients at Greatest Risk for Kidney Failure
5U01DK137269-04Kimberly Arriola · EMORY UNIVERSITY, GA · $762,917 · awarded Aug 28, 2026 · NIHImproving Access to Nephrology Treatment and Care among Patients at Greatest Risk for Kidney Failure Nearly 15% of U.S. adults have chronic kidney disease (CKD),1 yet because symptoms are often “silent,”2 only an estimated 12-19% are aware of their disease. A lack of a diagnosis results in substantial delays in accessing necessary care, such as referral to…
NAVIGATE Kidney: A Multi-Level Intervention to Reduce Kidney Health Disparities
5U01DK137272-04Lilia Cervantes · UNIVERSITY OF COLORADO DENVER, CO · $764,433 · awarded Aug 28, 2026 · NIHIndividuals experiencing progression from chronic kidney disease (CKD) to kidney failure face social challenges that contribute to kidney health disparities. Reducing the number of individuals who start KRT with a central venous catheter is critical because it is associated with a higher risk of fatal infection, non-fatal infection, hospitalization, and…
INSPIRE: INterventionS for Promoting kIdney tRansplant Empowerment
5U01DK137259-04Lili Chan · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY · $836,530 · awarded Aug 28, 2026 · NIH(30 Lines) Modified Grant Title: INSPIRE: INterventionS for Promoting kIdney tRansplant Empowerment Kidney transplantation (KTx) is the preferred treatment for patients with end-stage kidney disease. Despite recent changes to the kidney allocation system some individuals are less likely to receive a KTx evaluation, a multi-step process requiring patient…
Clinical and mechanistic studies defining optimal preparative approaches to infants with IL2RG/JAK3/RAG1/RAG2 SCID: a randomized trial of busulfan dosage
3U01AI184132-03S1JEFFERY AULETTA · NATIONAL MARROW DONOR PROGRAM, MN · $111,904 · awarded Aug 27, 2026 · NIHProject Summary Severe combined immunodeficiency (SCID) is a group of genetic disorders that abrogate T cell development and function. Allogeneic hematopoietic cell transplantation (HCT) is the standard treatment for the disease and can be performed successfully in SCID patients without the high dose pre-HCT busulfan conditioning due to the unique capacity…
Leveraging Prospective Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk Scores
3U01CA261339-05S1Fei Chen · UNIVERSITY OF SOUTHERN CALIFORNIA, CA · $300,000 · awarded Aug 27, 2026 · NIHAbstract There are stark differences in the burden of certain cancers across populations. For example, in comparison to individuals of European ancestry, African American men have a ~67% higher incidence rate of prostate cancer and Asian/Pacific Islander men and women have a 70% and 95% higher incidence rate of liver cancer, respectively. These differences…
Discovery Science Collaborative for CKDu
5U01DK130060-06VIVEK BHALLA · STANFORD UNIVERSITY, CA · $1,839,499 · awarded Aug 26, 2026 · NIHPROJECT SUMMARY / ABSTRACT The overall goal of the Discovery Science Collaborative for CKDu Renal Science Core is to bring the best investigative methods and scientific technology to the problem of CKDu. We will work closely with Field Epidemiology Sites, the Scientific Data Coordinating Center, NIDDK Leadership, the External Oversight Committee, and HHEAR…
Development of the anti-fentanyl monoclonal antibody, CSX-1004, for prophylaxis against fentanyl and fentanyl analog overdose
5U01DA063352-02Andrew Barrett · CESSATION THERAPEUTICS, LLC, CA · $2,089,891 · awarded Aug 25, 2026 · NIHThe opioid crisis in the United States has been dominated by illicitly manufactured fentanyl for a majority of the last decade, during which time over 400,000 Americans have died from unintentional overdose due to fentanyl or fentanyl analogs. The overdose reversal agent, naloxone, has been the cornerstone of opioid overdose management since 1971; however,…
Mechanistic clinical trial of blocking the IL-4/13 axis in asthmatics precision phenotyped in an aeroallergen challenge chamber before, during and after receipt of dupilumab
3U01AI158460-05S1Sunil Ahuja · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX · $490,019 · awarded Aug 19, 2026 · NIH7. Project Summary/Abstract We propose a high-impact, randomized, double-blind, placebo-controlled, mechanistic clinical trial aimed at elucidating the basis for the wide heterogeneity in severity of and treatment responses in persons with allergic rhinoconjunctivitis (ARC) and allergic asthma (AA). AA and ARC are highly prevalent, environmentally triggered…
Mapping Neurocognitive Complications of Pediatric Type 1 Diabetes (T1D) and Potential Risk and Protective Factors
5U01DK140764-03Aysenil Belger · UNIV OF NORTH CAROLINA CHAPEL HILL, NC · $559,495 · awarded Aug 19, 2026 · NIHModified Project Summary/Abstract Section Type 1 diabetes (T1D) is associated with neurocognitive complications that may emerge early after diagnosis and worsen over time. Risk may be pronounced in children diagnosed prepubertally, as the developing brain is likely particularly vulnerable to dysglycemia, diabetic ketoacidosis (DKA), and other metabolic…
Development of a Novel Therapeutic for Mitigating Radiation-Induced Microbiome Dysbiosis and Acute Gastrointestinal Syndrome
3U01AI172853-04S2Constantinos Broustas · COLUMBIA UNIVERSITY HEALTH SCIENCES, NY · $48,754 · awarded Aug 19, 2026 · NIHSUMMARY A mass casualty radiation event, such as the detonation of an improvised nuclear device or radiological dispersal device, could lead to severe hemorrhage, multi-organ failure, and infection, potentially leading to sepsis and/or death. The hematopoietic system and the gastrointestinal (GI) tract are among the most vulnerable tissues to radiation…
Bridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons
5U01MH130907-05ANTON ARKHIPOV · ALLEN INSTITUTE, WA · $2,201,458 · awarded Aug 18, 2026 · NIHBridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons The versatile and powerful functional properties of the brain are reflected in the neuronal activity patterns and computations, and their evolution over time due to learning, homeostatic plasticity, and other processes. The composition of brain circuits out of a large number of…
Clinical and mechanistic studies defining optimal preparative approaches to infants with IL2RG/JAK3/RAG1/RAG2 SCID: a randomized trial of busulfan dosage
5U01AI184132-03JEFFERY AULETTA · NATIONAL MARROW DONOR PROGRAM, MN · $958,627 · awarded Aug 18, 2026 · NIHProject Summary Severe combined immunodeficiency (SCID) is a group of genetic disorders that abrogate T cell development and function. Allogeneic hematopoietic cell transplantation (HCT) is the standard treatment for the disease and can be performed successfully in SCID patients without the high dose pre-HCT busulfan conditioning due to the unique capacity…
Funding institutes in the sample
| Institute | Awards | Funding |
|---|---|---|
| NIH | 457 | $445.8M |
| ALLCDC | 31 | $18.2M |
| FDA | 12 | $5.3M |
Most frequent institutions in the sample
- VANDERBILT UNIVERSITY MEDICAL CENTER — 29 awards
- JOHNS HOPKINS UNIVERSITY — 20 awards
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — 16 awards
- COLUMBIA UNIVERSITY HEALTH SCIENCES — 14 awards
- MASSACHUSETTS GENERAL HOSPITAL — 14 awards
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — 12 awards
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — 12 awards
- DUKE UNIVERSITY — 11 awards
Source: NIH RePORTER. Verify any award in the official record by searching its project number. See our data methodology for how this sample is built and its limitations.
Decision guide
Choose U01 when
Apply for U01 when an FOA you are responding to specifies the U01 mechanism, often because the program needs cross-site coordination.
Choose another mechanism when
For investigator-initiated work without NIH-led coordination, choose R01.
Who applies for U01
Investigators responding to U01 FOAs (which are typically more topic-specific than R01 PARs).
Compare nearby NIH grant mechanisms
Searchers often land on U01 while deciding between adjacent NIH activity codes. Compare scope, NIH staff involvement, budget scale, and applicant stage before choosing a funding opportunity.
Discrete, specified investigator-led research project
Multi-component centers with NIH program involvement
Large multi-component research with NIH involvement
For broad grant lookup, use the NIH grant search to find funded examples by activity code, PI, institution, and award year.
Search tips for U01
- U01 awards anchor NIH consortia like the HEAL Initiative, RECOVER (long COVID), and the Cancer Moonshot.
Search NIH grants by activity code
Find U01-funded PIs
U01 funding trends
U01 frequently asked questions
What is the difference between R01 and U01?
R01 is investigator-initiated with minimal NIH involvement once funded. U01 is a cooperative agreement with substantial NIH program staff involvement (steering committees, milestones).