UU Series — Cooperative Agreements

NIH U54 Grants — Specialized Center — Cooperative Agreement

Reviewed by Dr. Meng ZhaoLast reviewed June 9, 2026Data refreshed June 9, 2026Editorial standards

Multi-component centers with NIH program involvement

Funding

Multi-million per year

Duration

5 years

Eligibility

Multi-PI / multi-institution teams

Activity code

U54

What is the NIH U54 grant?

The U54 funds multi-component specialized centers similar to P50 but with NIH program staff substantially involved.

Recent U54 awards from NIH RePORTER

Examples of funded U54 projects across the last two fiscal years. The matching-award count comes from the full result set; funding totals, averages, rankings, and examples use the first 500 records returned by NIH RePORTER. Figures reflect a snapshot last refreshed on June 9, 2026.

Matching awards (last 2 FYs)
437
Full matching record count on RePORTER
Sampled funding
$807.7M
Sum of award amounts in the sample
Average award
$1.8M
Mean award amount in the sample

Example U54 projects from the sample

  • RARE and Atypical Diabetes Network(RADIANT)

    5U54DK118638-08
    ASHOK BALASUBRAMANYAM · BAYLOR COLLEGE OF MEDICINE, TX · $2,499,999 · awarded Jun 3, 2026 · NIH

    Diabetes is traditionally classified in two broad categories: autoimmune Type 1 and obesity-related Type 2. Numerous phenotypically and etiologically distinct forms exist and are emerging, collectively termed “atypical diabetes”, that do not fit into either category. We hypothesize that atypical diabetes comprises a spectrum that includes numerous forms,…

  • Center for Identification and Study of Individuals with Atypical Diabetes Mellitus

    5U54DK118612-08
    Louis Philipson · UNIVERSITY OF CHICAGO, IL · $2,500,000 · awarded Jun 3, 2026 · NIH

    Diabetes is traditionally classified in two broad categories: autoimmune Type 1 and obesity-related Type 2. Numerous phenotypically and etiologically distinct forms exist and are emerging, collectively termed “atypical diabetes”, that do not fit into either category. We hypothesize that atypical diabetes comprises a spectrum that includes numerous forms,…

  • Enhancing Maternal and Birthing Outcomes and Reproductive HeAlth through Community Engagement (EMBRACE) Center

    5U54HD113030-03
    Dara Mendez · UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA · $1,986,571 · awarded Jun 1, 2026 · NIH

    There are longstanding adverse maternal and reproductive health outcomes in the US that have increased over time. Researchers, community leaders and clinicians are increasingly advocating for and innovating approaches that center and empower the community’s lived experience. The Enhancing Maternal and Birthing outcomes and Reproductive HeAlth through…

  • Behavior of HIV in Viral Environments (B-HIVE)

    5U54AI170855-05
    Bruce Torbett · SEATTLE CHILDREN'S HOSPITAL, WA · $5,819,586 · awarded May 28, 2026 · NIH

    ABSTRACT, ADMINISTRATIVE CORE The Administrative Core will be the central hub of the B-HIVE Center and jointly directed by Stefan Sarafianos and Bruce Torbett. The Administrative Core will help to ensure that the Center achieves its full scientific potential by fostering a Center-wide collaborative and expansive environment that will make it greater than…

  • HARC: HIV accessory and regulatory complexes

    5U54AI170792-05
    Nevan Krogan · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA · $5,719,529 · awarded May 27, 2026 · NIH

    The mission of the Administrative Core is to support and promote the scientific and collaborative goals of the HARC Center. The Core will provide leadership that ensures strong oversight and representation of all stakeholders in decisions, facilitate the integration of research projects, and connect the HARC Center to the broader NIAID Centers for HIV…

  • Multi-sector, multi-level interventions for improving cancer prevention and control addressing persistent poverty

    5U54CA280812-04
    David Wetter · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, UT · $1,668,699 · awarded May 27, 2026 · NIH

    The overall, long-term goal of “HOPE & CAIRHE 2gether (HC2)” is to increase the reach of evidence-based cancer prevention and control interventions (EBIs) in areas of persistent poverty (PP). (For the purpose of this center grant’s projects and cores, “persistent poverty” is defined as a formal geographic classification developed by the U.S. Dept. of…

  • SDSU FUERTE: Faculty United towards Excellence in Research and Transformational Engagement

    5U54CA267789-05
    Maria Zuniga de Nuncio · SAN DIEGO STATE UNIVERSITY, CA · $180,600 · awarded May 27, 2026 · NIH

    OVERALL – Project Summary San Diego State University (SDSU) is proposing a new program called SDSU FUERTE or Faculty Unified towards Excellence in Research and Transformational Engagement. The goal of SDSU FUERTE is to recruit a diverse, nine-person cohort of early career of health sciences faculty focused on Latinx health disparities who will join SDSU in…

  • Center for Cancer Control in Persistent Poverty Areas (C3P2)

    5U54CA280770-04
    MARIA PISU · UNIVERSITY OF ALABAMA AT BIRMINGHAM, AL · $1,937,701 · awarded May 26, 2026 · NIH

    OVERALL ABSTRACT Cancer mortality, especially for obesity-related cancers like breast, prostate, and colorectal cancer, is higher in areas of the US affected by Persistent Poverty (PP), i.e., areas with a poverty rate of 20% or higher across four consecutive decennial censuses spanning 30 years (a formal geographic classification developed by the US…

  • NeuroTech Harbor - 21719

    3U54EB033664-04SB
    Sridevi Sarma · JOHNS HOPKINS UNIVERSITY, MD · $106,248 · awarded May 26, 2026 · NIH

    Project Summary / Abstract AUD affects ~28–29 million U.S. adults and drives ~$249–300B in annual costs. Despite this burden, clinicians and researchers lack a discreet, continuous way to quantify alcohol intake in real time. We propose to develop a discreet microneedle-based wearable that continuously measures alcohol in interstitial fluid to provide…

  • The RCMI Center for Cancer and Health Disparities Research

    5U54MD007595-19
    Guangdi Wang · XAVIER UNIVERSITY OF LOUISIANA, LA · $4,630,181 · awarded May 26, 2026 · NIH

    SUMMARY – OVERALL To sustain Xavier’s overall research momentum and advance to the next level of excellence in cancer and health disparities research, the RCMI Cancer and Health Disparities Research Center will implement program activities to support new and early-stage investigators, enhance core facilities to support Xavier researchers, and promote…

  • The Upstream Center: Income Interventions to Address the Fundamental Causes of Cancer

    5U54CA280811-04
    David Rehkopf · STANFORD UNIVERSITY, CA · $1,946,229 · awarded May 25, 2026 · NIH

    Persistent poverty areas, a formal geographic classification developed by the United States Department of Agriculture and codified by Congress, is defined as an area with a poverty rate of 20% or higher across four consecutive ten-year time periods, spanning 30 years. Cancer rates are higher in these areas, and improving cancer outcomes in these areas…

  • Geroscience of sex differences SCORE (GERO SCORE)

    1U54AG099000-01
    EILEEN CRIMMINS · UNIVERSITY OF SOUTHERN CALIFORNIA, CA · $1,499,966 · awarded May 22, 2026 · NIH

    The USC Geroscience Specialized Center of Research Excellence on Sex Differences in Aging (GeroSCORE) aims to fill important gaps in our understanding of how biological, behavioral, and population level factors contribute to sex differences in aging. While it is well established that women tend to have higher life expectancy than men worldwide, the…

Funding institutes in the sample

InstituteAwardsFunding
NIH405$771.9M
ALLCDC32$35.7M

Most frequent institutions in the sample

  1. JOHNS HOPKINS UNIVERSITY 25 awards
  2. STANFORD UNIVERSITY 14 awards
  3. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO 14 awards
  4. MASSACHUSETTS GENERAL HOSPITAL 11 awards
  5. BAYLOR COLLEGE OF MEDICINE 9 awards
  6. UNIVERSITY OF TX MD ANDERSON CAN CTR 9 awards
  7. UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH 9 awards
  8. WASHINGTON UNIVERSITY 9 awards

Source: NIH RePORTER. Verify any award in the official record by searching its project number. See our data methodology for how this sample is built and its limitations.

Decision guide

Choose U54 when

When the FOA specifies U54.

Choose another mechanism when

For non-coordinated centers, P50 is the alternative.

Who applies for U54

Multi-institution teams building NIH-coordinated centers (Rare Diseases Clinical Research Network, IDeA-CTR, etc.).

Compare nearby NIH grant mechanisms

Searchers often land on U54 while deciding between adjacent NIH activity codes. Compare scope, NIH staff involvement, budget scale, and applicant stage before choosing a funding opportunity.

For broad grant lookup, use the NIH grant search to find funded examples by activity code, PI, institution, and award year.

Search tips for U54

  • U54 awards identify NIH-coordinated networks.

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U54 funding trends

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