PP Series — Programs & Centers

NIH P50 Grants — Specialized Center Grant

Reviewed by Dr. Meng ZhaoLast reviewed June 9, 2026Data refreshed June 9, 2026Editorial standards

Topic-specific multi-component research center (e.g., SPORE)

Funding

Multi-million per year

Duration

5 years

Eligibility

Established research teams

Activity code

P50

What is the NIH P50 grant?

The P50 funds specialized research centers focused on a specific disease, organ system, or research theme. NCI SPOREs are P50s; NIMH Conte Centers are P50s.

Recent P50 awards from NIH RePORTER

Examples of funded P50 projects across the last two fiscal years. The matching-award count comes from the full result set; funding totals, averages, rankings, and examples use the first 500 records returned by NIH RePORTER. Figures reflect a snapshot last refreshed on June 9, 2026.

Matching awards (last 2 FYs)
242
Full matching record count on RePORTER
Sampled funding
$467.3M
Sum of award amounts in the sample
Average award
$1.9M
Mean award amount in the sample

Example P50 projects from the sample

  • Achilles Tendinopathy Center of Research Translation

    3P50AR080581-04S1
    LOUIS SOSLOWSKY · UNIVERSITY OF PENNSYLVANIA, PA · $80,147 · awarded Jun 5, 2026 · NIH

    Abstract The Achilles Tendinopathy Center of Research Translation (AT-CORT) at the University of Pennsylvania will foster fundamental discoveries to guide clinical translation, as well as develop and employ novel translational resources, models and technologies, to address the highly significant research and clinical challenge of Achilles tendinopathy.…

  • The Institute for Health Equity Research Catalyst Center

    5P50MD019475-03
    Lynne Richardson · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY · $759,917 · awarded Jun 3, 2026 · NIH

    PROJECT SUMMARY/ABSTRACT Health disparities science has advanced significantly over the last two decades, yet complex challenges remain. Improving the health and health care of populations, and by extension the health of all communities, will require a robust, transdisciplinary minority health and health disparities (MH/HD) research workforce with expertise…

  • UK ASCEND (Achieving Success in Community-Engaged research to elimiNate Disparities)

    5P50MD019476-03
    Nancy Schoenberg · UNIVERSITY OF KENTUCKY, KY · $598,149 · awarded Jun 1, 2026 · NIH

    Revised Abstract Overall ABSTRACT The University of Kentucky (UK) will establish Achieving Success in Community-Engaged research to elimiNate Disparities (UK ASCEND), driven by one overarching objective—to advance health by promoting community-engaged research (CER) success among ESIs. We propose the comprehensive ASCEND Scholars Program (ASP), a CER…

  • Iowa Cochlear Implant Clinical Research Center VIII

    5P50DC000242-39
    Bruce Gantz · UNIVERSITY OF IOWA, IA · $2,754,802 · awarded May 26, 2026 · NIH

    Program Director/Principal Investigator (Last, First, Middle): Gantz, Bruce J. PROJECT SUMMARY - OVERVIEW Cochlear implants (CI) have become the standard of care for managing profound sensorineural hearing loss. These devices provide significant improvement in word understanding in quiet but have limitations in noisy backgrounds. Difficulty understanding…

  • Southern California Research Center for ALPD and Cirrhosis

    5P50AA011999-28
    HIDEKAZU TSUKAMOTO · UNIVERSITY OF SOUTHERN CALIFORNIA, CA · $1,642,313 · awarded May 18, 2026 · NIH

    OVERALL - SUMMARY Alcohol-associated liver and pancreatic diseases (ALPD) and cirrhosis constitute leading metabolic diseases caused by alcohol use disorder around the globe. The Southern California Research Center for ALPD and Cirrhosis unifies 60 investigators from six academic institutions in Southern California to pursue a common mission of being a…

  • Impact of Cannabinoid Across the Lifespan (ICAL)

    5P50DA044118-07
    Daniele Piomelli · UNIVERSITY OF CALIFORNIA-IRVINE, CA · $2,336,157 · awarded May 12, 2026 · NIH

    IMPACT OF CANNABINOIDS ACROSS THE LIFESPAN (ICAL): SUMMARY Teenagers use cannabis more than any other recreational drug. Their developing brains may also be especially vulnerable to its effects, as epidemiological and experimental evidence suggests that frequent cannabis use in adolescence is associated with impairments in cognitive and affective…

  • Clinical Research Center for the Improved Prevention, Diagnosis, and Treatment of Vocal Hyperfunction

    3P50DC015446-09S2
    Robert Hillman · MASSACHUSETTS GENERAL HOSPITAL, MA · $154,774 · awarded Apr 28, 2026 · NIH

    Project Summary/Abstract Vocal hyperfunction (VH) is associated with the most frequently occurring types of voice disorders. These include benign vocal folds lesions (e.g., nodules and polyps) and dysphonia that occurs in the absence of concurrent pathology (e.g., muscle tension dysphonia). Effective prevention and clinical management of these disorders…

  • Cognitive Thalamus

    5P50MH132642-04
    SABINE KASTNER · PRINCETON UNIVERSITY, NJ · $3,102,305 · awarded Apr 28, 2026 · NIH

    PROJECT SUMMARY The overall goal of the Center is to derive a biologically plausible model for human thalamus function by identifying and modeling functional organization principles of higher-order thalamic computations and interactions between thalamus and cortex. The goal of Core A is to provide administrative support to all center projects and cores and…

  • Immunological, epigenetic and developmental determinants of early pregnancy success

    5P50HD112034-04
    Adrian Erlebacher · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA · $1,650,000 · awarded Apr 27, 2026 · NIH

    In the U.S., about 12% of women have impaired fecundity and 7% of couples have infertility, with 1/3 attributable to female factors. Underlying mechanisms remain largely unknown, however, even when more proximal pathologies are identified, thus precluding the development of accurate diagnostics and personalized therapies. In addition, pregnancies in…

  • Clinical Research Center for the Improved Prevention, Diagnosis, and Treatment of Vocal Hyperfunction

    3P50DC015446-09S1
    Robert Hillman · MASSACHUSETTS GENERAL HOSPITAL, MA · $66,941 · awarded Apr 27, 2026 · NIH

    Project Summary/Abstract Vocal hyperfunction (VH) is associated with the most frequently occurring types of voice disorders. These include benign vocal folds lesions (e.g., nodules and polyps) and dysphonia that occurs in the absence of concurrent pathology (e.g., muscle tension dysphonia). Effective prevention and clinical management of these disorders…

  • Neurobiology and Cognitive Role of Slow Brain Network Fluctuations

    5P50MH109429-09
    CHARLES SCHROEDER · NATHAN S. KLINE INSTITUTE FOR PSYCH RES, NY · $3,120,567 · awarded Apr 17, 2026 · NIH

    CENTER ABSTRACT: Patterns of ongoing thought vary over time, and experiences like “mind-wandering” show that cognition is often decoupled from an ongoing task. A traditional assumption is that states of off-task cognition reflects a cognitive error. An emerging alternative view is that switching between “off-task” and on- task states is a fundamental…

  • UW ALACRITY Center for Psychosocial Interventions Research

    5P50MH115837-08
    Aaron Lyon · UNIVERSITY OF WASHINGTON, WA · $2,187,556 · awarded Apr 14, 2026 · NIH

    ABSTRACT. The purpose of the UW ALACRITY Center is to address critical problems in the implementation of evidence-based psychosocial clinical interventions (CI) (e.g., psychotherapies) in nonspecialty service settings that are accessible to underserved communities (i.e., primary care clinics and schools). Use of CI is inhibited by longstanding problems with…

Funding institutes in the sample

InstituteAwardsFunding
NIH237$460.6M
FDA5$6.8M

Most frequent institutions in the sample

  1. JOHNS HOPKINS UNIVERSITY 9 awards
  2. UNIVERSITY OF MICHIGAN AT ANN ARBOR 8 awards
  3. UNIVERSITY OF PITTSBURGH AT PITTSBURGH 8 awards
  4. WASHINGTON UNIVERSITY 8 awards
  5. MASSACHUSETTS GENERAL HOSPITAL 8 awards
  6. SLOAN-KETTERING INST CAN RESEARCH 7 awards
  7. UNIVERSITY OF PENNSYLVANIA 7 awards
  8. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO 7 awards

Source: NIH RePORTER. Verify any award in the official record by searching its project number. See our data methodology for how this sample is built and its limitations.

Decision guide

Choose P50 when

Apply for P50 when you have a coherent translational program — the SPORE structure (basic + clinical + developmental projects + cores) is the canonical model.

Choose another mechanism when

For non-translational basic research, P01 may fit better.

Who applies for P50

Research teams building thematic centers around specific diseases or methods.

Compare nearby NIH grant mechanisms

Searchers often land on P50 while deciding between adjacent NIH activity codes. Compare scope, NIH staff involvement, budget scale, and applicant stage before choosing a funding opportunity.

For broad grant lookup, use the NIH grant search to find funded examples by activity code, PI, institution, and award year.

Search tips for P50

  • P50 SPOREs anchor NCI cancer translational research at most major academic centers.

Search NIH grants by activity code

Find P50-funded PIs

P50 funding trends

Related NIH grant types