PP Series — Programs & Centers

NIH P01 Grants — Program Project Grant

Multi-project, multi-PI program with shared theme and core resources

Funding

Multi-million per year (varies by IC)

Duration

5 years

Eligibility

Established investigator teams with shared scientific theme

Activity code

P01

What is the NIH P01 grant?

The P01 is a Program Project Grant — a single award supporting 3–5 individual research projects unified by a common scientific theme, plus shared cores (administrative, imaging, biostatistics, etc.). Each project has its own PI; the P01 has an overall PI who coordinates the program.

Recent P01 awards (last 24 months)

Live data from NIH RePORTER

402

Awards

$874,099,358

Total funding (sample)

$2,174,377

Average award

Sample reflects up to the most recent 500 NIH RePORTER awards with this activity code in the past 24 months. Total project count is the full RePORTER count.

Most recently awarded P01 grants

Modifiable Drivers of Expansion and Malignant Transformation from Clonal Hematopoiesis

MARGARET GOODELL · BAYLOR COLLEGE OF MEDICINE, TX · NIH

$2,261,447

FY 2026

Project: 5P01CA265748-05

Developing Pluripotent Stem Cells to Model and Treat Lung Disease

Darrell Kotton · BOSTON UNIVERSITY MEDICAL CAMPUS, MA · NIH

$2,784,712

FY 2026

Project: 5P01HL170952-03

Drivers of influenza A virus transmission in humans

Anice Lowen · EMORY UNIVERSITY, GA · NIH

$2,060,576

FY 2026

Project: 5P01AI186819-02

Molecular mechanisms of calcification: roles and opportunities in diseases of aging

Francesca Marassi · MEDICAL COLLEGE OF WISCONSIN, WI · NIH

$2,605,267

FY 2026

Project: 5P01AG081167-04

Changes in the Ionic Basis of GABAergic Inhibition that Contribute to Post-Traumatic Epilepsy

Kevin Staley · MASSACHUSETTS GENERAL HOSPITAL, MA · NIH

$1,299,137

FY 2026

Project: 5P01NS127769-04

Pitt Center for Accelerating Phage Therapy (P-CAPT)

Daria Van Tyne · UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA · NIH

$2,160,947

FY 2026

Project: 1P01AI195376-01

Multi-Omics Analysis of Broadly Neutralizing Antibodies and Therapeutic Vaccination

Dan Barouch · BETH ISRAEL DEACONESS MEDICAL CENTER, MA · NIH

$1,500,997

FY 2026

Project: 5P01AI177687-04

Neuroendocrine Prostate Cancer Progression and Novel Therapeutic Vulnerabilities

Lucia Languino · THOMAS JEFFERSON UNIVERSITY, PA · NIH

$1,656,379

FY 2026

Project: 1P01CA298993-01A1

Top NIH institutes funding P01

By total funding in the last 24 months

  1. 1.NIH402 · $874,099,358

Top funded institutions

Most P01 awards in the last 24 months

  1. 1.UNIVERSITY OF PENNSYLVANIA15 awards
  2. 2.STANFORD UNIVERSITY12 awards
  3. 3.DANA-FARBER CANCER INST12 awards
  4. 4.COLUMBIA UNIVERSITY HEALTH SCIENCES11 awards
  5. 5.WASHINGTON UNIVERSITY10 awards
  6. 6.UNIVERSITY OF CALIFORNIA, SAN FRANCISCO10 awards

Who applies for P01

Teams of established investigators at one or more institutions sharing a coherent research theme.

When to choose P01

Choose P01 when you have a coherent multi-project program that benefits from shared cores and is too large for any single R01.

When NOT to choose P01

P01s have high overhead. Consider whether 3–5 separate R01s would work as well.

Search tips for P01

  • P01 awards identify large research programs at major institutions.

Search NIH grants by activity code

Open NIH grant search

Find P01-funded PIs

Open PI Finder

P01 funding trends

Open trend search

Related NIH grant types

PP30

Center Core Grant

Shared resource cores supporting NIH-funded investigators

PP50

Specialized Center Grant

Topic-specific multi-component research center (e.g., SPORE)

RR01

Research Project Grant

Discrete, specified investigator-led research project

UU01

Research Project — Cooperative Agreement

Investigator-led research with NIH staff substantial involvement