UU Series — Cooperative Agreements

NIH UM1 Grants — Multi-Component Cooperative Agreement

Reviewed by Dr. Meng ZhaoLast reviewed June 9, 2026Data refreshed June 9, 2026Editorial standards

Large multi-component research with NIH involvement

Funding

Multi-million per year

Duration

5 years

Eligibility

Multi-component team programs

Activity code

UM1

What is the NIH UM1 grant?

UM1 awards fund large multi-component research programs that combine multiple research projects and cores under a single cooperative agreement umbrella.

Recent UM1 awards from NIH RePORTER

Examples of funded UM1 projects across the last two fiscal years. The matching-award count comes from the full result set; funding totals, averages, rankings, and examples use the first 500 records returned by NIH RePORTER. Figures reflect a snapshot last refreshed on June 9, 2026.

Matching awards (last 2 FYs)
457
Full matching record count on RePORTER
Sampled funding
$1.7B
Sum of award amounts in the sample
Average award
$3.7M
Mean award amount in the sample

Example UM1 projects from the sample

  • Pediatric Heart Network New York Consortium

    5UM1HL172720-03
    Marc Richmond · COLUMBIA UNIVERSITY HEALTH SCIENCES, NY · $465,943 · awarded Jun 5, 2026 · NIH

    PROJECT SUMMARY / ABSTRACT Congenital heart defects are the most common and resource intensive birth defects managed in the United States and have high morbidity and mortality. Further, significant differences are known to exist in both outcomes and resource requirements. Mechanisms of these differences—and optimal targets for intervention —are unknown.…

  • Massively parallel characterization of variants and elements impacting transcriptional regulation in dynamic cellular systems

    3UM1HG011966-05S1
    Jay Shendure · UNIVERSITY OF WASHINGTON, WA · $1,584,050 · awarded Jun 4, 2026 · NIH

    SUMMARY / ABSTRACT A major fraction of heritability for common diseases, as well as for the penetrance and expressivity of rare diseases, partitions to distal regulatory elements in the human genome, overwhelmingly cell type-specific enhancers. However, a rate-limiting challenge for the field has been how to identify the specific variants, elements and…

  • The Ohio State University as a Lead Academic Organization (LAO) for the Experimental Therapeutics Clinical Trials Network

    3UM1CA186712-09S1
    WILLIAM CARSON · OHIO STATE UNIVERSITY, OH · $1,697,412 · awarded Jun 1, 2026 · NIH

    PROJECT SUMMARY This project encompasses a multi-disciplinary team of basic scientists and clinical investigators dedicated to finding effective new therapies for patients with cancer. The Ohio State University Comprehensive Cancer Center (OSUCCC) is a comprehensive biomedical research campus with strong collaborations between experienced investigators from…

  • University of North Carolina Global HIV Prevention and Treatment Clinical Trials Unit

    3UM1AI069423-20S2
    Joseph Eron · UNIV OF NORTH CAROLINA CHAPEL HILL, NC · $1,417 · awarded May 29, 2026 · NIH

    The University of North Carolina (UNC) Global HIV Prevention and Treatment Clinical Trials Unit (CTU) has a well-established record of high quality, innovative clinical research, strong network and scientific leadership. The CTU engages with critically important populations infected with and at high risk of HIV in southeastern US, southern Africa and…

  • University of North Carolina Global HIV Prevention and Treatment Clinical Trials Unit

    3UM1AI069423-20S1
    Joseph Eron · UNIV OF NORTH CAROLINA CHAPEL HILL, NC · $75,363 · awarded May 28, 2026 · NIH

    The University of North Carolina (UNC) Global HIV Prevention and Treatment Clinical Trials Unit (CTU) has a well-established record of high quality, innovative clinical research, strong network and scientific leadership. The CTU engages with critically important populations infected with and at high risk of HIV in southeastern US, southern Africa and…

  • INSPIRE: Innovative Strategies for Personalized Immunotherapies and Reservoir Eradication

    5UM1AI191237-02
    R. Brad Jones · WEILL MEDICAL COLL OF CORNELL UNIV, NY · $2,915,052 · awarded May 28, 2026 · NIH

    PROJECT SUMMARY/ABSTRACT Antiretroviral therapy (ART) is highly effective against HIV-1 and has saved millions of lives. However, ART is not curative, and people living with HIV (PWH) require life-long therapy because they harbor integrated replication-competent proviruses that quickly fuel rebound when ART is discontinued. This reservoir of infected cells…

  • Clinical and Translational Science Award (CTSA) UM1 at Columbia University

    1UM1TR006153-01
    Muredach Reilly · COLUMBIA UNIVERSITY HEALTH SCIENCES, NY · $10,714,971 · awarded May 27, 2026 · NIH

    Project Summary Our Clinical and Translational Science Award (CTSA) hub is situated in Upper Manhattan at the Irving Institute for Clinical and Translational Research (Irving Institute) of Columbia University (CU), based at the CU Irving Medical Center (CUIMC). Our evolution as institutional leaders and maturation as a comprehensive CTSA hub enables us to…

  • Indiana Clinical and Translational Sciences Institute

    5UM1TR004402-04
    Sharon Moe · INDIANA UNIVERSITY INDIANAPOLIS, IN · $5,271,891 · awarded May 26, 2026 · NIH

    The Indiana Clinical and Translational Sciences Institute (Indiana CTSI) was created in 2008 as a statewide partnership to accelerate clinical and translational research by the three research universities, Indiana, Purdue and Notre Dame, with partner health care systems and providers, community and patient stakeholders, local foundations, corporate and…

  • North Carolina Translational and Clinical Sciences Institute (NC TraCS)

    5UM1TR004406-04
    NICHOLAS SHAHEEN · UNIV OF NORTH CAROLINA CHAPEL HILL, NC · $8,960,667 · awarded May 26, 2026 · NIH

    The North Carolina Translational and Clinical Sciences Institute (TraCS) is a dynamic regional network of universities, research institutes, healthcare providers, and >250 community collaborators across our state. Based at UNC Chapel Hill, TraCS has strategically fostered partnerships with NC A&T, which brings expertise in workforce development,…

  • Oklahoma ACE: Molecular Destruction of Autoimmune Disease to Aid Clinical Trail Success

    5UM1AI144292-08
    JUDITH JAMES · OKLAHOMA MEDICAL RESEARCH FOUNDATION, OK · $767,250 · awarded May 22, 2026 · NIH

    Project Summary The Oklahoma ACE (OACE) aims to understand autoimmune disease biology through interdisciplinary, collaborative research integrating clinical and basic questions. Prior OACE work as both a Basic and Clinical ACE has significantly advanced our understanding of autoimmune disease genetics, development, flare, and heterogeneity. The OACE has…

  • North American Star Consortium

    3UM1CA186644-09S1
    Philippe Bedard · UNIVERSITY HEALTH NETWORK, ON · $1,770,712 · awarded May 20, 2026 · NIH

    PROJECT SUMMARY / ABSTRACT This administrative supplement request seeks continued support for the Early Therapeutics Clinical Trials Network (ETCTN) UM1 North American Star Consortium (NASC), led by the Princess Margaret Cancer Centre (LAO) with partnering Academic Organizations including the Moffitt Cancer Center (MCC), Virginia Commonwealth University…

  • Biospecimen procurement and tissue microarray manufacture for the CHTN

    5UM1CA239752-08
    Christopher Moskaluk · UNIVERSITY OF VIRGINIA, VA · $419,647 · awarded May 19, 2026 · NIH

    The University of Virginia (UVA) currently supports the “adult” Mid-Atlantic Division of the Cooperative Human Tissue Network (CHTN), offering high quality human tissue and biofluid specimens procured, stored and shipped under optimized standard operating procedures. A team of consent staff recruit subjects at UVA clinics, with the consent including…

Funding institutes in the sample

InstituteAwardsFunding
NIH457$1.7B

Most frequent institutions in the sample

  1. JOHNS HOPKINS UNIVERSITY 44 awards
  2. UNIVERSITY OF CALIFORNIA LOS ANGELES 26 awards
  3. FRED HUTCHINSON CANCER CENTER 23 awards
  4. UNIV OF NORTH CAROLINA CHAPEL HILL 21 awards
  5. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI 13 awards
  6. EMORY UNIVERSITY 13 awards
  7. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO 9 awards
  8. UNIVERSITY OF CALIFORNIA, SAN DIEGO 9 awards

Source: NIH RePORTER. Verify any award in the official record by searching its project number. See our data methodology for how this sample is built and its limitations.

Decision guide

Choose UM1 when

When the FOA specifies UM1 — common for clinical trials networks and large consortia.

Choose another mechanism when

When P01/P50 structure suits your program better.

Who applies for UM1

Established multi-institution teams responding to specific UM1 FOAs.

Compare nearby NIH grant mechanisms

Searchers often land on UM1 while deciding between adjacent NIH activity codes. Compare scope, NIH staff involvement, budget scale, and applicant stage before choosing a funding opportunity.

For broad grant lookup, use the NIH grant search to find funded examples by activity code, PI, institution, and award year.

Search tips for UM1

  • UM1 awards identify NIH consortia and clinical trial networks.

Search NIH grants by activity code

Find UM1-funded PIs

UM1 funding trends

Related NIH grant types