NIH PAR · OD · R01
PAR-25-322: Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The Stephen I. Katz Early Stage Investigator Research Project Grant supports an innovative project that represents a change in research direction for an early stage investigator (ESI) and for which no preliminary data exist. Applications submitted to this Notice of Funding Opportunity (NOFO) must not include preliminary data. Applications must include a separate attachment describing the change in research direction.
- NOFO number
- PAR-25-322
- Type
- PAR
- Activity code
- R01
- Primary institute
- OD · NIH Office of the Director
- Clinical trials
- Not Allowed
- Posted
- Aug 25, 2025
- Opens
- Aug 25, 2025
- Expires
- Aug 26, 2028
PAR-25-322 due dates
5 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| September 26, 2025 | October 28, 2025 | December 29, 2025 | March 2026 | May 2026 | July 2026 |
| January 27, 2026 | February 26, 2026 | April 27, 2026 | July 2026 | October 2026 | December 2026 |
| May 27, 2026 | June 26, 2026 | Not Applicable | November 2026 | January 2027 | April 2027 |
| September 28, 2026 | October 27, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
| January 26, 2027 | February 26, 2027 | Not Applicable | July 2027 | October 2027 | December 2027 |
| May 28, 2027 | June 28, 2027 | Not Applicable | November 2027 | January 2028 | April 2028 |
| September 28, 2027 | October 28, 2027 | Not Applicable | March 2028 | May 2028 | July 2028 |
| January 26, 2028 | February 24, 2028 | Not Applicable | July 2028 | October 2028 | December 2028 |
| May 26, 2028 | June 27, 2028 | Not Applicable | November 2028 | January 2029 | April 2029 |
Projects funded under PAR-25-322
NIH RePORTER lists 20 projects funded under PAR-25-322 in FY2022–FY2026, with $11.4M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
20
Distinct projects, FY2022–FY2026
New awards
20
Type 1 (new project) award records
NIH funding
$11.4M
Award dollars under PAR-25-322, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 20 | 20 | $11.4M |
Institutions with the most funding
- Children's Hosp of Philadelphia$853K · 1 project
- Univ of Arkansas for Med Scis$823K · 2 projects
- Colorado State University$809K · 1 project
- University of Kentucky$802K · 1 project
- University of Colorado$769K · 1 project
- University of Hawaii at Manoa$715K · 1 project
- Baylor College of Medicine$701K · 1 project
- University of California at Davis$693K · 1 project
Most recent new awards
- Metabolic aberrant stem cell and niche inflammation in obese and non-obese EO-CRC (opens NIH RePORTER)
Columbia University Health Sciences · 1R37CA306888-01A1 · NCI · Notice Sep 14, 2026
$597KR37
- Leveraging Mobile Tools to Investigate Emotion Dynamics and Behavior in Autistic Youth with Depression (opens NIH RePORTER)
Medical College of Wisconsin · 1R01HD121476-01A1 · NICHD · Notice Sep 14, 2026
$555KR01
- Prenatal PFAS-Microplastics Mixtures and Early Neurodevelopment: multi-omics informed biological mechanisms (opens NIH RePORTER)
University of Hawaii at Manoa · 1R01ES038825-01 · NIEHS · Notice Sep 11, 2026
$715KR01
- Mechanisms of Sodium-Driven Glial Dysfunction in Hypertensive Retinopathy (opens NIH RePORTER)
Meharry Medical College · 1R01EY039212-01 · NEI · Notice Sep 10, 2026
$654KR01
- Mechanisms Linking Mild-to-Moderate TBI to Long-Term Cardiovascular Disease (opens NIH RePORTER)
University of Texas Rio Grande Valley · 1R01HL187311-01 · NHLBI · Notice Sep 7, 2026
$539KR01
- Precision Nanomedicine Targeting Inflammatory and Osteoclast Pathways in Periodontal Disease (opens NIH RePORTER)
University of Illinois at Chicago · 1R56DE036222-01 · NIDCR · Notice Sep 2, 2026
$577KR56
What its predecessor PAR-24-075 funded
PAR-25-322 reissues PAR-24-075. Its funding history is the best guide to who wins under this program: 38 projects and $44.7M in FY2022–FY2026.
Projects funded
38
Distinct projects, FY2022–FY2026
New awards
38
Type 1 (new project) award records
NIH funding
$44.7M
Award dollars under PAR-24-075, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 1 | 1 | $525K |
| FY2025 | 23 | 22 | $20.8M |
| FY2026 | 32 | 15 | $23.4M |
Institutions with the most funding
- University of California, San Diego$3.7M · 2 projects
- University of California at Davis$3.4M · 1 project
- Northwestern University$2.9M · 2 projects
- University of South Dakota$2.8M · 1 project
- Hugo W. Moser Res Inst Kennedy Krieger$2.4M · 2 projects
- Arizona State University-Tempe Campus$1.8M · 2 projects
- Children's Hosp of Philadelphia$1.6M · 1 project
- Temple Univ of the Commonwealth$1.6M · 1 project
Most recent new awards
- Role of human NK cells in the immune response to Coccidioides (opens NIH RePORTER)
Northern California Institute/Res/Edu · 1R56AI189590-01A1 · NIAID · Notice Sep 3, 2026
$713KR56
- The Role of Salivary Proteins in Modulating Taste Perception in Humans (opens NIH RePORTER)
University of South Carolina at Columbia · 1R01DC022540-01A1 · NIDCD · Notice Sep 3, 2026
$611KR01
- Bacteriophages in dental caries: Roles and potential as a therapy (opens NIH RePORTER)
Ohio State University · 1R01DE034689-01A1 · NIDCR · Notice Aug 6, 2026
$667KR01
- Aligning Machine Learning Models with Clinician Knowledge for Understanding, Prediction, and Prevention of Suicide (opens NIH RePORTER)
Wellesley College · 1R01MH139486-01A1 · NIMH · Notice Jul 27, 2026
$708KR01
- In Vivo Cartilage Mechanics Across Stages of Joint Health (opens NIH RePORTER)
Carnegie-Mellon University · 1R01AR085576-01A1 · NIAMS · Notice Jul 7, 2026
$487KR01
- RBC-bound cell-free DNA as a predictor of acute anemia in sickle cell disease (opens NIH RePORTER)
Emory University · 1R01HL178546-01A1 · NHLBI · Notice Jun 3, 2026
$798KR01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
22 NIH institutes and offices take applications under PAR-25-322. Contact the program officer at the institute that fits your research before applying.
- OD · NIH Office of the Director
- NEI · National Eye Institute
- NHLBI · National Heart, Lung, and Blood Institute
- NHGRI · National Human Genome Research Institute
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NIAID · National Institute of Allergy and Infectious Diseases
- NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
- NIBIB · National Institute of Biomedical Imaging and Bioengineering
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCD · National Institute on Deafness and Other Communication Disorders
- NIDCR · National Institute of Dental and Craniofacial Research
- NIDDK · National Institute of Diabetes and Digestive and Kidney Diseases
- NIEHS · National Institute of Environmental Health Sciences
- NIMH · National Institute of Mental Health
- NINR · National Institute of Nursing Research
- NIMHD · National Institute on Minority Health and Health Disparities
- NLM · National Library of Medicine
- NCCIH · National Center for Complementary and Integrative Health
- ORIP
- NCI · National Cancer Institute
- ORWH
Related notices
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Notices of Special Interest (NOSIs)
NIH has attached 9 NOSIs to PAR-25-322; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.
Award terms
- Application types allowed
- NewResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited but need to reflect the actual needs of the proposed project.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.  
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-24-075.
- Companion NOFOs: PAR-25-323.
Other open NOFOs for R01
- RFA-OD-27-004INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)OD · next due Jun 15, 2027
- PAR-25-077CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Basic Research on Chemical Threats that Affect the Nervous System (R01 Clinical Trial Not Allowed)NINDS · next due Oct 16, 2026
- PAR-25-371Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)NHGRI · next due Oct 20, 2026
- PAR-25-271NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required)NCCIH · next due Oct 20, 2026
- PAR-25-267NCCIH Multi-Site Feasibility Clinical Trials of Mind and Body Interventions (R01 Clinical Trial Required)NCCIH · next due Oct 20, 2026
- PAR-25-268Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)NCCIH · next due Oct 20, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.