NIH PAR · NIA · R01
PAR-27-081: Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of this Notice of Funding Opportunity (NOFO) is to support investigators who have the interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds.Through this NOFO, NIH wishes to stimulate research in:Discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Eye Institute (NEI), and/or National…
- NOFO number
- PAR-27-081
- Type
- PAR
- Activity code
- R01
- Primary institute
- NIA · National Institute on Aging
- Clinical trials
- Not Allowed
- Posted
- May 4, 2026
- Opens
- May 5, 2026
- Expires
- Mar 6, 2027
PAR-27-081 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| June 05, 2026 * | July 05, 2026 * | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 05, 2026 * | November 05, 2026 * | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 05, 2027 * | March 05, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
What its predecessor PAR-24-088 funded
PAR-27-081 reissues PAR-24-088. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 1 project and $793K in FY2022–FY2026.
Projects funded
1
Distinct projects, FY2022–FY2026
New awards
1
Type 1 (new project) award records
NIH funding
$793K
Award dollars under PAR-24-088, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 1 | 1 | $396K |
| FY2026 | 1 | 0 | $396K |
Institutions with the most funding
- Vanderbilt University$793K · 1 project
Funding institutes
- NIMH$793K · 2
Activity codes funded
- R012 records
Most recent new awards
- Regulation of metabotropic glutamate receptor activity by protein/protein interactions (opens NIH RePORTER)
Vanderbilt University · 1R01MH136164-01A1 · NIMH · Notice Nov 29, 2024
$396KR01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
4 NIH institutes and offices take applications under PAR-27-081. Contact the program officer at the institute that fits your research before applying.
- NIA · National Institute on Aging
- NEI · National Eye Institute
- NIDA · National Institute on Drug Abuse
- NIMH · National Institute of Mental Health
Related notices
NIH lists no related notices for PAR-27-081 yet.
Award terms
- Application types allowed
- New Resubmission Revision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited but need to reflect the actual needs of the proposed project.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 5 years NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-24-088.
Other open NOFOs for R01
- PAR-27-090Palliative Care Research Across the Lifespan: Leveraging the Palliative Care Consortium (R01 Clinical Trial Optional)NIA · next due Feb 5, 2027
- PAR-25-279New Approaches for Measuring Brain Changes Across Longer Timespans (R01 Clinical Trial Optional)NIA · next due Feb 5, 2027
- PAR-25-374Translational Bioinformatics and Experimental Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimers Disease and Related Dementias (R01 Clinical Trial Not Allowed)NIA · next due Feb 8, 2027
- PAR-25-379Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)NIDA · next due Oct 21, 2026
- PAR-25-322Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)OD · next due Jan 26, 2027
- PA-25-301NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)NIH · next due Feb 5, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.