NIH PAR · NIA · R01
PAR-25-279: New Approaches for Measuring Brain Changes Across Longer Timespans (R01 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of this funding opportunity is to encourage multidisciplinary investigators to develop new approaches or apply existing approaches in novel ways to measure brain activity, connectivity, genomics, or other aspects across the age spectrum of neurodevelopment. The overarching goal is to extend our understanding of brain development and aging, including studies of the neurodevelopmental origins of later health and disease. Research can include healthy human participants of any age, specific clinical groups such as those with cognitive, motor, or affective regulation challenges, and/or animal research on these domains of function. The studies can focus on longitudinal neuroanatomical…
- NOFO number
- PAR-25-279
- Type
- PAR
- Activity code
- R01
- Primary institute
- NIA · National Institute on Aging
- Clinical trials
- Optional
- Posted
- Nov 25, 2024
- Opens
- Jan 5, 2025
- Expires
- May 8, 2027
PAR-25-279 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 05, 2025 | March 05, 2025 * | Not Applicable | July 2025 | October 2025 | December 2025 |
| June 05, 2025 | July 05, 2025 * | Not Applicable | November 2025 | January 2026 | April 2026 |
| October 05, 2025 | November 05, 2025 * | Not Applicable | March 2026 | May 2026 | July 2026 |
| February 05, 2026 | March 05, 2026 * | Not Applicable | July 2026 | October 2026 | December 2026 |
| June 05, 2026 | July 05, 2026 * | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 05, 2026 | November 05, 2026 * | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 05, 2027 | March 05, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
Projects funded under PAR-25-279
NIH RePORTER lists 2 projects funded under PAR-25-279 in FY2022–FY2026, with $1.5M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
2
Distinct projects, FY2022–FY2026
New awards
2
Type 1 (new project) award records
NIH funding
$1.5M
Award dollars under PAR-25-279, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 2 | 2 | $1.5M |
Institutions with the most funding
- Indiana University Indianapolis$791K · 1 project
- Yale University$674K · 1 project
Funding institutes
- NIA$791K · 1
- NICHD$674K · 1
Activity codes funded
- R012 records
Most recent new awards
- Longitudinal study of the role of rapid eye movement sleep in hippocampus ontogenesis and memory formation across lifetime (opens NIH RePORTER)
Yale University · 1R01HD123637-01 · NICHD · Notice Sep 8, 2026
$674KR01
- Personalized Medicine under the Co-evolution of Connectomes and Pathological Proteins (opens NIH RePORTER)
Indiana University Indianapolis · 1R01AG095242-01A1 · NIA · Notice Sep 1, 2026
$791KR01
What its predecessor PAR-24-160 funded
PAR-25-279 reissues PAR-24-160. Its funding history is the best guide to who wins under this program: 2 projects and $1.5M in FY2022–FY2026.
Projects funded
2
Distinct projects, FY2022–FY2026
New awards
2
Type 1 (new project) award records
NIH funding
$1.5M
Award dollars under PAR-24-160, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 1 | 1 | $401K |
| FY2026 | 2 | 1 | $1.1M |
Institutions with the most funding
- Univ of North Carolina Chapel Hill$789K · 1 project
- Washington University$683K · 1 project
Funding institutes
- NIBIB$789K · 2
- NIA$683K · 1
Activity codes funded
- R013 records
Most recent new awards
- A fiber implant for long-term, deep-brain imaging and manipulation in mouse models of Alzheimer disease (opens NIH RePORTER)
Washington University · 1R01AG095248-01 · NIA · Notice Dec 30, 2025
$683KR01
- Knowledge-empowered Lifespan Neuroimage Analysis (opens NIH RePORTER)
Univ of North Carolina Chapel Hill · 1R01EB037169-01 · NIBIB · Notice Jun 26, 2025
$401KR01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
4 NIH institutes and offices take applications under PAR-25-279. Contact the program officer at the institute that fits your research before applying.
- NIA · National Institute on Aging
- NIBIB · National Institute of Biomedical Imaging and Bioengineering
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NCI · National Cancer Institute
Related notices
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Award terms
- Application types allowed
- NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited but need to reflect the actual needs of the proposed project.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-24-160.
- Companion NOFOs: PAR-25-272.
Other open NOFOs for R01
- PAR-27-090Palliative Care Research Across the Lifespan: Leveraging the Palliative Care Consortium (R01 Clinical Trial Optional)NIA · next due Feb 5, 2027
- PAR-27-081Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)NIA · next due Feb 5, 2027
- PAR-25-374Translational Bioinformatics and Experimental Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimers Disease and Related Dementias (R01 Clinical Trial Not Allowed)NIA · next due Feb 8, 2027
- PAR-25-379Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)NIDA · next due Oct 21, 2026
- PAR-25-322Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)OD · next due Jan 26, 2027
- PA-25-301NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)NIH · next due Feb 5, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.