NIH PAR · NIA · R21

PAR-25-272: New Approaches for Measuring Brain Changes Across Longer Timespans (R21 Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Oct 16, 2026Expires May 8, 2027

The purpose of this funding opportunity is to encourage multidisciplinary investigators to submit applications developing exploratory, highly novel new approaches, or innovative applications of existing approaches to measure brain activity, connectivity, genomics, or other aspects across the age spectrum of neurodevelopment. The overarching goal is to extend our understanding of brain development and aging, including studies of the neurodevelopmental origins of later health and disease, by improving repeated measures across longer epochs of the lifespan to better predict outcomes at later ages. . Research can include healthy human participants of any age, specific clinical groups such those…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-272
Type
PAR
Activity code
R21
Primary institute
NIA · National Institute on Aging
Clinical trials
Optional
Posted
Nov 25, 2024
Opens
Jan 16, 2025
Expires
May 8, 2027

PAR-25-272 due dates

2 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-272
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 16, 2025March 16, 2025 *Not ApplicableJuly 2025October 2025December 2025
June 16, 2025July 16, 2025 *Not ApplicableNovember 2025January 2026April 2026
October 16, 2025November 16, 2025 *Not ApplicableMarch 2026May 2026July 2026
February 16, 2026March 16, 2026 *Not ApplicableJuly 2026October 2026December 2026
June 16, 2026July 16, 2026 *Not ApplicableNovember 2026January 2027April 2027
October 16, 2026November 16, 2026 *Not ApplicableMarch 2027May 2027July 2027
February 16, 2027March 16, 2027 *Not ApplicableJuly 2027October 2027December 2027

Projects funded under PAR-25-272

NIH RePORTER lists 3 projects funded under PAR-25-272 in FY2022–FY2026, with $1.2M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

3

Distinct projects, FY2022–FY2026

New awards

3

Type 1 (new project) award records

NIH funding

$1.2M

Award dollars under PAR-25-272, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-272
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202633$1.2M

Institutions with the most funding

  1. Columbia Univ New York Morningside$443K · 1 project
  2. Northern Arizona University$417K · 1 project
  3. Columbia University Health Sciences$390K · 1 project

Funding institutes

  • NIA$807K · 2
  • NICHD$443K · 1

Activity codes funded

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

3 NIH institutes and offices take applications under PAR-25-272. Contact the program officer at the institute that fits your research before applying.

  • NIA · National Institute on Aging
  • NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • NCI · National Cancer Institute

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Award terms

Application types allowed
NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Direct costs are limited to 275,000 over the two-year project period. No more than 200,000 in direct costs are allowed in any single year.
Project period
The scope of the proposed project should determine the project period. The maximum project period is 2 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-24-161.
  • Companion NOFOs: PAR-25-279.

Other open NOFOs for R21

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

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