NIH PAR · NCI · R21

PAR-25-143: Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Oct 16, 2026Expires Jan 8, 2028

The purpose of this Funding Opportunity Announcement (FOA) is to support studies that will identify, develop, and/or test strategies for overcoming barriers to the adoption, adaptation, integration, scale-up, and sustainability of evidence-based interventions, practices, programs, tools, treatments, guidelines, and policies. Studies that promote equitable dissemination and implementation of evidence-based interventions among underrepresented communities are encouraged. Conversely, there is a benefit in understanding circumstances that create a need to stop or reduce (de-implement) the use of practices that are ineffective, unproven, low-value, or harmful. In addition, studies to advance…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-143
Type
PAR
Activity code
R21
Primary institute
NCI · National Cancer Institute
Clinical trials
Optional
Posted
Oct 31, 2024
Opens
Jan 16, 2025
Expires
Jan 8, 2028

PAR-25-143 due dates

4 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-143
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 16, 2025March 16, 2025 *May 07, 2025 *July 2025October 2025December 2025
June 16, 2025July 16, 2025 *September 07, 2025 *November 2025January 2026April 2026
October 16, 2025November 16, 2025 *January 07, 2026 *March 2026May 2026July 2026
February 16, 2026March 16, 2026 *May 07, 2026 *July 2026October 2026December 2026
June 16, 2026July 16, 2026 *Not ApplicableNovember 2026January 2027April 2027
October 16, 2026November 16, 2026 *Not ApplicableMarch 2027May 2027July 2027
February 16, 2027March 16, 2027 *Not ApplicableJuly 2027October 2027December 2027
June 16, 2027July 16, 2027 *Not ApplicableNovember 2027January 2028April 2028
October 16, 2027November 16, 2027 *Not ApplicableMarch 2028May 2028July 2028

Projects funded under PAR-25-143

NIH RePORTER lists 10 projects funded under PAR-25-143 in FY2022–FY2026, with $3.4M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

10

Distinct projects, FY2022–FY2026

New awards

10

Type 1 (new project) award records

NIH funding

$3.4M

Award dollars under PAR-25-143, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-143
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY20261110$3.4M

Institutions with the most funding

  1. Massachusetts General Hospital$474K · 1 project
  2. University of California Los Angeles$447K · 1 project
  3. Duke University$444K · 1 project
  4. University of Texas at Austin$442K · 1 project
  5. University of Texas Hlth Sci Ctr Houston$401K · 1 project
  6. Purdue University$347K · 1 project
  7. Albert Einstein College of Medicine$252K · 1 project
  8. University of North Texas Hlth Sci Ctr$195K · 1 project

Funding institutes

  • NCI$848K · 2
  • NIA$821K · 2
  • NIAID$447K · 3
  • NCCIH$444K · 1
  • NIMH$442K · 1
  • FIC$189K · 1
  • NINDS$183K · 1

Activity codes funded

Most recent new awards

What its predecessor PAR-22-109 funded

PAR-25-143 reissues PAR-22-109. Its funding history is the best guide to who wins under this program: 16 projects and $6.0M in FY2022–FY2026.

Projects funded

16

Distinct projects, FY2022–FY2026

New awards

16

Type 1 (new project) award records

NIH funding

$6.0M

Award dollars under PAR-22-109, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-22-109
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202355$1.2M
FY2024106$1.9M
FY2025155$2.5M
FY202650$505K

Institutions with the most funding

  1. University of Pennsylvania$894K · 2 projects
  2. University of Kentucky$461K · 1 project
  3. New York University$443K · 1 project
  4. Northwestern University$440K · 1 project
  5. Univ of Massachusetts Med Sch Worcester$425K · 1 project
  6. University of Pittsburgh at Pittsburgh$389K · 1 project
  7. University of South Carolina at Columbia$387K · 1 project
  8. Yale University$381K · 1 project

Funding institutes

  • NICHD$1.3M · 7
  • NCI$1.1M · 7
  • FIC$1.0M · 6
  • NIAID$842K · 4
  • NIDA$630K · 3
  • NIMH$440K · 2
  • NIA$389K · 2
  • NINR$373K · 4

Activity codes funded

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

20 NIH institutes and offices take applications under PAR-25-143. Contact the program officer at the institute that fits your research before applying.

  • NCI · National Cancer Institute
  • NHGRI · National Human Genome Research Institute
  • NIA · National Institute on Aging
  • NIAAA · National Institute on Alcohol Abuse and Alcoholism
  • NIAID · National Institute of Allergy and Infectious Diseases
  • NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
  • NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • NIDCD · National Institute on Deafness and Other Communication Disorders
  • NIDCR · National Institute of Dental and Craniofacial Research
  • NIDA · National Institute on Drug Abuse
  • NIEHS · National Institute of Environmental Health Sciences
  • NIMH · National Institute of Mental Health
  • NINDS · National Institute of Neurological Disorders and Stroke
  • NINR · National Institute of Nursing Research
  • NIMHD · National Institute on Minority Health and Health Disparities
  • FIC · Fogarty International Center
  • NCCIH · National Center for Complementary and Integrative Health
  • THRO
  • ODP
  • OBSSR

Related notices

  1. Jan 28, 2026 · NOT-OD-26-029

    NIH Removing AIDS Application Due Dates from NOFOs. See Notice NOT-OD-26-029.

  2. Mar 31, 2025

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.

  3. Jan 17, 2025 · NOT-NS-25-016

    Notice of Change: NINDS Interests for PAR-25-143 Dissemination and Implementation Research in Health R21 Clinical Trial Optional)".

  4. Dec 20, 2024 · NOT-CA-25-001

    Notice of Correction to the Dissemination and Implementation Research in Health" Notices of Funding Opportunity PAR-25-143 and PAR-25-144. See Notice NOT-CA-25-001.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025.

  5. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  6. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Notices of Special Interest (NOSIs)

NIH has attached 18 NOSIs to PAR-25-143; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.

Award terms

Application types allowed
NewResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
The combined budget for direct costs for the two-year project period may not exceed 275,000. No more than 200,000 may be requested in a single year.
Project period
The maximum project period is 2 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

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About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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