NIH PAR · NCI · R21

PAR-25-321: Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Oct 16, 2026Expires Jan 8, 2028

Through this engineering-oriented Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to encourage submissions of exploratory/developmental Bioengineering Research Grant (EBRG) applications to demonstrate feasibility and potential utility of new capabilities or improvements in quality, speed, efficacy, operability, costs, and/or accessibility of solutions to problems in basic biomedical, pre-clinical, or clinical research, clinical care delivery, or accessibility.

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-321
Type
PAR
Activity code
R21
Primary institute
NCI · National Cancer Institute
Clinical trials
Optional
Posted
Dec 10, 2024
Opens
Jan 16, 2025
Expires
Jan 8, 2028

PAR-25-321 due dates

4 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-321
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 16, 2025March 16, 2025 *Not ApplicableJuly 2025October 2025December 2025
June 16, 2025July 16, 2025 *Not ApplicableNovember 2025January 2026April 2026
October 16, 2025November 16, 2025 *Not ApplicableMarch 2026May 2026July 2026
February 16, 2026March 16, 2026 *Not ApplicableJuly 2026October 2026December 2026
June 16, 2026July 16, 2026 *Not ApplicableNovember 2026January 2027April 2027
October 16, 2026November 16, 2026 *Not ApplicableMarch 2027May 2027July 2027
February 16, 2027March 16, 2027 *Not ApplicableJuly 2027October 2027December 2027
June 16, 2027July 16, 2027 *Not ApplicableNovember 2027January 2028April 2028
October 16, 2027November 16, 2027 *Not ApplicableMarch 2028May 2028July 2028

Projects funded under PAR-25-321

NIH RePORTER lists 3 projects funded under PAR-25-321 in FY2022–FY2026, with $1.3M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

3

Distinct projects, FY2022–FY2026

New awards

3

Type 1 (new project) award records

NIH funding

$1.3M

Award dollars under PAR-25-321, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-321
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202633$1.3M

Institutions with the most funding

  1. J. David Gladstone Institutes$486K · 1 project
  2. University of California, San Diego$421K · 1 project
  3. Georgia Institute of Technology$396K · 1 project

Funding institutes

  • NCI$1.3M · 3

Activity codes funded

Most recent new awards

What its predecessor PAR-22-091 funded

PAR-25-321 reissues PAR-22-091. Its funding history is the best guide to who wins under this program: 12 projects and $4.6M in FY2022–FY2026.

Projects funded

12

Distinct projects, FY2022–FY2026

New awards

12

Type 1 (new project) award records

NIH funding

$4.6M

Award dollars under PAR-22-091, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-22-091
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202366$1.2M
FY202483$1.9M
FY202543$1.3M
FY202610$193K

Institutions with the most funding

  1. University of Tx MD Anderson Can Ctr$837K · 2 projects
  2. Sloan-Kettering Inst Can Research$453K · 1 project
  3. Case Western Reserve University$434K · 1 project
  4. Massachusetts General Hospital$424K · 1 project
  5. Georgetown University$401K · 1 project
  6. Tufts University Medford$395K · 1 project
  7. University of Texas at Austin$390K · 1 project
  8. University of Kansas Medical Center$389K · 1 project

Funding institutes

  • NCI$4.6M · 19

Activity codes funded

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-321. Contact the program officer at the institute that fits your research before applying.

  • NCI · National Cancer Institute
  • none

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Notices of Special Interest (NOSIs)

NIH has attached 1 NOSI to PAR-25-321; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.

Award terms

Application types allowed
NewResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
The combined budget for direct costs for the two-year project period may not exceed 275,000. No more than 200,000 may be requested in any single year.
Project period
The maximum project period is 2 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-22-091.

Other open NOFOs for R21

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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