NIH RFA · OD · R21

RFA-OD-27-003: INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Jun 15, 2027Expires Jun 16, 2028

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This Notice of Funding Opportunity (NOFO) invites researchers to submit applications for support of new exploratory and developmental research projects that address critical needs for Down syndrome projects, as articulated in the INCLUDE Project objectives. For example, such projects could assess the feasibility of a novel area of investigation or a new experimental system that has the potential to enhance health-related research. Another example could include the unique and innovative use of an…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
RFA-OD-27-003
Type
RFA
Activity code
R21
Primary institute
OD · NIH Office of the Director
Clinical trials
Not Allowed
Posted
May 12, 2026
Opens
Sep 15, 2026
Expires
Jun 16, 2028

RFA-OD-27-003 due dates

2 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for RFA-OD-27-003
NewRenewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
October 15, 2026October 15, 2026Not ApplicableMarch 2027May 2027July 2027
June 15, 2027June 15, 2027Not ApplicableNovember 2027January 2028April 2028
June 15, 2028June 15, 2028Not ApplicableNovember 2028January 2029April 2029

What its predecessor RFA-OD-21-007 funded

RFA-OD-27-003 reissues RFA-OD-21-007. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 10 projects and $4.4M in FY2022–FY2026.

Projects funded

10

Distinct projects, FY2022–FY2026

New awards

10

Type 1 (new project) award records

NIH funding

$4.4M

Award dollars under RFA-OD-21-007, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under RFA-OD-21-007
Fiscal yearAward recordsNew awardsFunding
FY202233$710K
FY202330$591K
FY202422$491K
FY202575$2.4M
FY202610$195K

Institutions with the most funding

  1. University of Colorado Denver$857K · 2 projects
  2. Icahn School of Medicine at Mount Sinai$462K · 1 project
  3. Massachusetts General Hospital$459K · 1 project
  4. UT Southwestern Medical Center$451K · 1 project
  5. University of Illinois at Urbana-Champaign$446K · 1 project
  6. Lundquist Institute for Biomedical Innovation at Harbor-Ucla Medical Center$444K · 1 project
  7. University of Texas at Austin$430K · 1 project
  8. University of Colorado$430K · 1 project

Funding institutes

  • NICHD$1.3M · 3
  • NHLBI$1.3M · 6
  • NCI$462K · 1
  • NIA$459K · 2
  • NIDCD$430K · 2
  • NIAID$429K · 2

Activity codes funded

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

12 NIH institutes and offices take applications under RFA-OD-27-003. Contact the program officer at the institute that fits your research before applying.

  • OD · NIH Office of the Director
  • NEI · National Eye Institute
  • NHLBI · National Heart, Lung, and Blood Institute
  • NIA · National Institute on Aging
  • NIAID · National Institute of Allergy and Infectious Diseases
  • NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
  • NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • NIDCD · National Institute on Deafness and Other Communication Disorders
  • NIDCR · National Institute of Dental and Craniofacial Research
  • NLM · National Library of Medicine
  • ORIP
  • NCI · National Cancer Institute

Related notices

NIH lists no related notices for RFA-OD-27-003 yet.

Award terms

Application types allowed
New Resubmission Revision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are limited to a maximum of 275,000 direct costs for the two-year project period of the award. No more than 200,000 may be requested in any single year.
Project period
The scope of the proposed project should determine the project period. The maximum project period is 2 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
NIH intends to commit an estimated 1,000,000 to fund up to 5 awards per year in FY2027, FY2028, and FY2029.The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Future year amounts will depend on annual appropriations.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of RFA-OD-21-007.

Other open NOFOs for R21

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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