NIH PAR · NEI · R21
PAR-25-357: NEI Research Grant for Vision-Related Secondary Data Analysis (R21 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The goal of this funding opportunity announcement (FOA) is to fund meritorious vision-related research projects that involve secondary data analyses using existing database resources. The development of statistical methodology necessary for improving methods to analyze vision health data using existing vision data may also be proposed.
- NOFO number
- PAR-25-357
- Type
- PAR
- Activity code
- R21
- Primary institute
- NEI · National Eye Institute
- Clinical trials
- Not Allowed
- Posted
- Jan 2, 2025
- Opens
- Jan 16, 2025
- Expires
- Oct 17, 2027
PAR-25-357 due dates
4 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 16, 2025 | March 16, 2025 * | May 07, 2025 * | July 2025 | October 2025 | December 2025 |
| June 16, 2025 | July 16, 2025 * | September 07, 2025 * | November 2025 | January 2026 | April 2026 |
| October 16, 2025 | November 16, 2025 * | January 07, 2026 * | March 2026 | May 2026 | July 2026 |
| February 16, 2026 | March 16, 2026 * | May 07, 2026 * | July 2026 | October 2026 | December 2026 |
| June 16, 2026 | July 16, 2026 * | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 16, 2026 | November 16, 2026 * | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 16, 2027 | March 16, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
| June 16, 2027 | July 16, 2027 * | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 16, 2027 | November 16, 2027 * | Not Applicable | March 2028 | May 2028 | July 2028 |
Projects funded under PAR-25-357
NIH RePORTER lists 4 projects funded under PAR-25-357 in FY2022–FY2026, with $1.8M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
4
Distinct projects, FY2022–FY2026
New awards
4
Type 1 (new project) award records
NIH funding
$1.8M
Award dollars under PAR-25-357, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 4 | 4 | $1.8M |
Institutions with the most funding
- Rand Corporation$510K · 1 project
- Massachusetts General Hospital$454K · 1 project
- University of Minnesota$439K · 1 project
- Ohio State University$429K · 1 project
Funding institutes
- NEI$1.8M · 4
Activity codes funded
- R214 records
Most recent new awards
- Ocular stiffness predicts aqueous humor dynamics and IOP fluctuations (opens NIH RePORTER)
Ohio State University · 1R21EY038921-01 · NEI · Notice Sep 17, 2026
$429KR21
- Understanding the Role of Artificial Intelligence in Expanding Access to Diabetic Retinopathy Screening (opens NIH RePORTER)
University of Minnesota · 1R21EY038977-01 · NEI · Notice Aug 31, 2026
$439KR21
- Establishing a risk-profile for Cerebral Visual Impairment (opens NIH RePORTER)
Massachusetts General Hospital · 1R21EY038227-01A1 · NEI · Notice Aug 19, 2026
$454KR21
- The Effects of Scope of Practice Regulations on Eye Health Care (opens NIH RePORTER)
Rand Corporation · 1R21EY037742-01A1 · NEI · Notice Jul 27, 2026
$510KR21
What its predecessor PAR-22-141 funded
PAR-25-357 reissues PAR-22-141. Its funding history is the best guide to who wins under this program: 17 projects and $7.3M in FY2022–FY2026.
Projects funded
17
Distinct projects, FY2022–FY2026
New awards
17
Type 1 (new project) award records
NIH funding
$7.3M
Award dollars under PAR-22-141, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 5 | 5 | $2.2M |
| FY2024 | 7 | 6 | $2.3M |
| FY2025 | 7 | 5 | $2.2M |
| FY2026 | 2 | 1 | $639K |
Institutions with the most funding
- University of Pennsylvania$929K · 2 projects
- Ohio State University$878K · 2 projects
- University of Colorado Denver$814K · 2 projects
- Schepens Eye Research Institute$557K · 1 project
- National Opinion Research Center$494K · 1 project
- Weill Medical Coll of Cornell Univ$466K · 1 project
- Wills Eye Health System$460K · 1 project
- University of California, San Francisco$451K · 1 project
Funding institutes
- NEI$7.3M · 21
Activity codes funded
- R2121 records
Most recent new awards
- Vision disorders in concussed kids secondary data analysis grant (opens NIH RePORTER)
Ohio State University · 1R21EY037763-01 · NEI · Notice Apr 2, 2026
$445KR21
- Implementation of Instrument-Based Vision Screening in Primary Care Pediatric Offices: Enhancing Early Detection of Sight Threatening Disorders within a Children's Hospital System (opens NIH RePORTER)
Children's Hospital Med Ctr of Akron · 1R21EY035712-01A1 · NEI · Notice Aug 15, 2025
$393KR21
- Identifying Clusters of Vision and Eye Health Problems Using Secondary Surveillance Data (opens NIH RePORTER)
National Opinion Research Center · 1R21EY037293-01 · NEI · Notice Aug 14, 2025
$494KR21
- Large Language Models for Studying Amblyopia Treatment, Adherence, and Outcomes (opens NIH RePORTER)
Oregon Health & Science University · 1R21EY037312-01 · NEI · Notice Jul 21, 2025
$438KR21
- Diabetic Retinal Neurodegeneration in Youth Onset Diabetes (opens NIH RePORTER)
Johns Hopkins University · 1R21EY036948-01 · NEI · Notice Jan 27, 2025
$155KR21
- A generalizable deep learning platform for unifying quantification of experimental autoimmune uveitis (opens NIH RePORTER)
University of Tennessee Health Sci Ctr · 1R21EY036199-01A1 · NEI · Notice Jan 24, 2025
$231KR21
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under PAR-25-357. Contact the program officer at the institute that fits your research before applying.
- NEI · National Eye Institute
- none
Related notices
Jan 28, 2026 · NOT-OD-26-029
NIH Removing AIDS Application Due Dates from NOFOs.
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Notices of Special Interest (NOSIs)
NIH has attached 1 NOSI to PAR-25-357; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.
Award terms
- Application types allowed
- NewResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- The NEI permits direct costs up to 275,000 for the entire two-year project period, plus applicable F&A for consortia. No more than 200,000 in direct costs may be requested in any single year.
- Project period
- The total project period for an application submitted in response to this funding opportunity may not exceed two years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-22-141.
Other open NOFOs for R21
- PA-25-304NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)NIH · next due Oct 16, 2026
- PA-25-306NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)NIH · next due Oct 16, 2026
- PAR-25-369Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)NHGRI · next due Oct 20, 2026
- PAR-25-442Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)NCATS · next due Feb 17, 2027
- RFA-OD-27-003INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)OD · next due Jun 15, 2027
- PAR-25-068Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed)NIDDK · next due Oct 16, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.