NIH PAR · NLM · R01
PAR-25-131: Computational Approaches to Curation at Scale for Biomedical Research Assets (R01 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
NLM wishes to accelerate access to, and availability of, secure, complete datasets and computational models that can serve as the basis for transformative biomedical discoveries. Innovative at-scale computational approaches that increase the speed and scope of curation processes are needed for data mining and knowledge discovery from growing quantities of biomedical data being produced from ongoing data science advances.
- NOFO number
- PAR-25-131
- Type
- PAR
- Activity code
- R01
- Primary institute
- NLM · National Library of Medicine
- Clinical trials
- Not Allowed
- Posted
- Oct 29, 2024
- Opens
- Dec 27, 2024
- Expires
- Apr 16, 2027
PAR-25-131 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| January 28, 2025 | February 24, 2025 | April 25, 2025 | July 2025 | October 2025 | December 2025 |
| May 15, 2025 | June 13, 2025 | August 15, 2025 | November 2025 | January 2026 | April 2026 |
| September 15, 2025 | October 15, 2025 | December 15, 2025 | March 2026 | May 2026 | July 2026 |
| January 15, 2026 | February 13, 2026 | April 15, 2026 | July 2026 | October 2026 | December 2026 |
| May 15, 2026 | June 15, 2026 | Not Applicable | November 2026 | January 2027 | April 2027 |
| September 15, 2026 | October 15, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
| January 15, 2027 | February 17, 2027 | Not Applicable | July 2027 | October 2027 | December 2027 |
Projects funded under PAR-25-131
NIH RePORTER lists 2 projects funded under PAR-25-131 in FY2022–FY2026, with $360K in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
2
Distinct projects, FY2022–FY2026
New awards
1
Type 1 (new project) award records
NIH funding
$360K
Award dollars under PAR-25-131, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 2 | 1 | $360K |
Institutions with the most funding
- University of Chicago$360K · 1 project
- University of Missouri-Columbia$1 · 1 project
Funding institutes
- NLM$360K · 2
Activity codes funded
- R012 records
Most recent new awards
- A multi-agent AI system for automated curation and functional annotation of enzymes in human gut microbiome (opens NIH RePORTER)
University of Missouri-Columbia · 1R01LM015024-01 · NLM · Notice May 22, 2026
$1R01
What its predecessor PAR-20-304 funded
PAR-25-131 reissues PAR-20-304. Its funding history is the best guide to who wins under this program: 9 projects and $10.1M in FY2022–FY2026.
Projects funded
9
Distinct projects, FY2022–FY2026
New awards
8
Type 1 (new project) award records
NIH funding
$10.1M
Award dollars under PAR-20-304, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 3 | 2 | $1.1M |
| FY2023 | 6 | 3 | $2.0M |
| FY2024 | 8 | 2 | $2.5M |
| FY2025 | 8 | 1 | $3.5M |
| FY2026 | 3 | 0 | $1.0M |
Institutions with the most funding
- University of Pittsburgh at Pittsburgh$1.4M · 1 project
- University of Chicago$1.4M · 1 project
- Emory University$1.4M · 1 project
- Stanford University$1.3M · 1 project
- University of Virginia$1.3M · 1 project
- California Institute of Technology$1.1M · 1 project
- University of Wisconsin-Madison$999K · 1 project
- University of Illinois at Chicago$948K · 1 project
Funding institutes
- NLM$10.1M · 28
Activity codes funded
- R0128 records
Most recent new awards
- A computational framework for quality assessment and curation of models at scale (opens NIH RePORTER)
University of Pittsburgh at Pittsburgh · 1R01LM014673-01 · NLM · Notice Sep 1, 2025
$1.4MR01
- Enabling data quality assessment of organelle genomes archived on GenBank through novel open-source software tools (opens NIH RePORTER)
Fort Hays State University · 1R01LM014506-01 · NLM · Notice Sep 10, 2024
$120KR01
- Automated methods for standardization and enhancement of metadata in biomedical databases (opens NIH RePORTER)
University of Wisconsin-Madison · 1R01LM014593-01 · NLM · Notice Aug 7, 2024
$332KR01
- Automated Indexing for Publication Types and Study Designs (opens NIH RePORTER)
University of Illinois at Chicago · 1R01LM014292-01 · NLM · Notice Aug 2, 2023
$322KR01
- Continually Adaptive Machine Learning Platform for Personalized Biomedical Literature Curation and Exploration (opens NIH RePORTER)
University of Virginia · 1R01LM014012-01A1 · NLM · Notice Jul 31, 2023
$335KR01
- AddBiomechanics: Automatic Processing and Sharing of Human Movement Data (opens NIH RePORTER)
Stanford University · 1R01LM014154-01A1 · NLM · Notice Jul 13, 2023
$334KR01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under PAR-25-131. Contact the program officer at the institute that fits your research before applying.
- NLM · National Library of Medicine
- none
Related notices
May 14, 2025 · NOT-LM-25-001
Notice of Change to Advisory Council Review for PAR-25-131.
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Award terms
- Application types allowed
- NewRenewalResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are limited to 250,000 direct costs per year excluding consortium F&A costs) and need to reflect the actual needs of the proposed project.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 4 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-20-304.
Other open NOFOs for R01
- PAR-26-040Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional)NLM · next due Feb 5, 2027
- PAR-26-042Research Grants in Clinical Informatics (R01 Clinical Trial Optional)NLM · next due Feb 5, 2027
- PAR-25-235Personal Health Informatics for Delivering Actionable Insights to Individuals (R01 Clinical Trial Optional)NLM
- PAR-25-379Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)NIDA · next due Oct 21, 2026
- PAR-25-322Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)OD · next due Jan 26, 2027
- PA-25-301NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)NIH · next due Feb 5, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.