NIH RFA · NINDS · U01

RFA-NS-27-015: BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Feb 8, 2027Expires Oct 5, 2027

This funding announcement, issued by the Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative, seeks transformative, cutting-edge, and innovative research that embraces new technologies, ideas, and approaches to understand brain circuit function and contributions to behavior. It is a component of the BRAIN Initiative Connectivity Across Scales (BRAIN CONNECTS) Program, which aims to lay the scientific foundation for the next generation of neural circuit-based approaches for preventing and treating devastating brain disorders.This Notice of Funding Opportunity (NOFO) supports Specialized Projects to develop current or emerging technologies to generate…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
RFA-NS-27-015
Type
RFA
Activity code
U01
Primary institute
NINDS · National Institute of Neurological Disorders and Stroke
Clinical trials
Not Allowed
Posted
May 28, 2026
Opens
Jun 9, 2026
Expires
Oct 5, 2027

RFA-NS-27-015 due dates

2 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for RFA-NS-27-015
NewRenewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
July 09, 2026Not ApplicableNot ApplicableNovember 2026January 2027April 2027
February 08, 2027Not ApplicableNot ApplicableJuly 2027October 2027December 2027
October 04, 2027Not ApplicableNot ApplicableMarch 2028May 2028July 2028

What its predecessor RFA-NS-22-049 funded

RFA-NS-27-015 reissues RFA-NS-22-049. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 13 projects and $58.4M in FY2022–FY2026.

Projects funded

13

Distinct projects, FY2022–FY2026

New awards

13

Type 1 (new project) award records

NIH funding

$58.4M

Award dollars under RFA-NS-22-049, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under RFA-NS-22-049
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202366$11.4M
FY202494$14.0M
FY2025133$22.9M
FY202670$10.1M

Institutions with the most funding

  1. Allen Institute$16.7M · 3 projects
  2. University of California, San Francisco$5.9M · 1 project
  3. Boston Children's Hospital$5.2M · 1 project
  4. Johns Hopkins University$4.8M · 1 project
  5. Broad Institute, Inc.$4.6M · 1 project
  6. Harvard University$4.3M · 1 project
  7. Massachusetts General Hospital$4.2M · 1 project
  8. University of Chicago$4.1M · 1 project

Funding institutes

  • NINDS$58.4M · 35

Activity codes funded

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

10 NIH institutes and offices take applications under RFA-NS-27-015. Contact the program officer at the institute that fits your research before applying.

  • NINDS · National Institute of Neurological Disorders and Stroke
  • NEI · National Eye Institute
  • NIA · National Institute on Aging
  • NIAAA · National Institute on Alcohol Abuse and Alcoholism
  • NIBIB · National Institute of Biomedical Imaging and Bioengineering
  • NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • NIDCD · National Institute on Deafness and Other Communication Disorders
  • NIDA · National Institute on Drug Abuse
  • NIMH · National Institute of Mental Health
  • NCCIH · National Center for Complementary and Integrative Health

Related notices

NIH lists no related notices for RFA-NS-27-015 yet.

Award terms

Application types allowed
New The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are not limited but need to reflect the actual needs of the proposed project.
Project period
The maximum project period is 3 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The NIH BRAIN Initiative intends to commit an estimated total of 10M in the first year for this funding announcement to fund approximately 3-6 awards.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of RFA-NS-22-049.

Other open NOFOs for U01

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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