NIH RFA · NIMH · U01
RFA-MH-26-140: BRAIN Initiative: Brain Behavior Quantification and Synchronization- Next Generation Sensor Technology Development (U01 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
This NOFO solicits applications for next generation sensor and bioelectronic device development that will synchronize with brain recordings. The sensor and neural recording data will be used to generate new computational models of behavior in human and animal models. There has been a lack of quantitative approaches and models to understand the complexity of human and animal behavior in naturalistic settings. This NOFO focuses on the development of next generation sensors to acquire data and synchronize it with simultaneous brain recordings to build computational models.
- NOFO number
- RFA-MH-26-140
- Type
- RFA
- Activity code
- U01
- Primary institute
- NIMH · National Institute of Mental Health
- Clinical trials
- Optional
- Posted
- Oct 23, 2024
- Opens
- May 13, 2025
- Expires
- Jun 16, 2027
RFA-MH-26-140 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| June 13, 2025 | Not Applicable | Not Applicable | November 2025 | January 2026 | April 2026 |
| June 15, 2026 | June 15, 2026 | Not Applicable | November 2026 | January 2027 | April 2027 |
| June 15, 2027 | June 15, 2027 | Not Applicable | November 2027 | January 2028 | April 2028 |
Projects funded under RFA-MH-26-140
NIH RePORTER lists 2 projects funded under RFA-MH-26-140 in FY2022–FY2026, with $3.0M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
2
Distinct projects, FY2022–FY2026
New awards
2
Type 1 (new project) award records
NIH funding
$3.0M
Award dollars under RFA-MH-26-140, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 2 | 2 | $3.0M |
Institutions with the most funding
- University of Pennsylvania$1.7M · 1 project
- Duke University$1.4M · 1 project
Funding institutes
- NIMH$3.0M · 2
Activity codes funded
- U012 records
Most recent new awards
- A smart lens platform for real-world event capture and synchronized deep brain dynamics (opens NIH RePORTER)
Duke University · 1U01MH143789-01 · NIMH · Notice Sep 10, 2026
$1.4MU01
- SMART-DBS: A Symptom-Manipulating, Adaptive and Responsive Therapy for continuous brain-behavioral recording and stimulation (opens NIH RePORTER)
University of Pennsylvania · 1U01MH144347-01 · NIMH · Notice Jul 31, 2026
$1.7MU01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
11 NIH institutes and offices take applications under RFA-MH-26-140. Contact the program officer at the institute that fits your research before applying.
- NIMH · National Institute of Mental Health
- NEI · National Eye Institute
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NIBIB · National Institute of Biomedical Imaging and Bioengineering
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCD · National Institute on Deafness and Other Communication Disorders
- NIDA · National Institute on Drug Abuse
- NINDS · National Institute of Neurological Disorders and Stroke
- NCCIH · National Center for Complementary and Integrative Health
- OBSSR
Related notices
Mar 31, 2025
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.
Nov 20, 2024 · NOT-OD-25-034
Notice of Participation of OBSSR in RFA-MH-26-140 BRAIN Initiative: Brain Behavior Quantification and Synchronization- Next Generation Sensor Technology Development U01 Clinical Trial Optional)". See Notice NOT-OD-25-034.April 4, 2024 - Overview of Grant Application and Review Changes for Due…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Notices of Special Interest (NOSIs)
NIH has attached 1 NOSI to RFA-MH-26-140; 1 are active. A NOSI flags a topic an institute wants to fund through this NOFO.
Award terms
- Application types allowed
- NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited but need to reflect the actual needs of the proposed project.
- Project period
- The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- NIMH and partner components intend to commit an estimated total of 10 million to fund 6-8 awards for each receipt date
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Other open NOFOs for U01
- PAR-25-352National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U01 Clinical Trial Optional)NIMH · next due Oct 25, 2026
- PAR-25-180First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Neuromodulatory Device-based Interventions for Psychiatric Disorders (U01 Clinical Trial Required)NIMH · next due Feb 17, 2027
- PAR-26-116Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)OD · next due Feb 5, 2027
- RFA-NS-27-015BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)NINDS · next due Feb 8, 2027
- RFA-CA-27-019Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)NCI · next due Oct 19, 2026
- RFA-DE-27-001Community Engagement Evaluation and Data Coordination (CEED) Hub to Advance Data and Practice Transformation for Optimizing Oral Health for All (U01, Clinical Trial Not Allowed)NIDCR · next due Oct 19, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.