NIH PAR · OD · U01
PAR-26-116: Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The goal of this program is to support collaborative translational research projects aligned with NIH efforts to enhance the translation of basic biological discoveries into clinical applications that improve health. It encourages high quality science demonstrating the potential to result in understanding an important disease process or lead to new therapeutic interventions, diagnostics, or prevention strategies within the research interests and priorities of the participating NIH Institutes/Centers (ICs).Specifically, the program seeks to broaden and strengthen translational research collaborations between basic and clinical researchers both within and outside NIH to accelerate and enhance…
- NOFO number
- PAR-26-116
- Type
- PAR
- Activity code
- U01
- Primary institute
- OD · NIH Office of the Director
- Clinical trials
- Optional
- Posted
- Dec 8, 2025
- Opens
- Jan 5, 2026
- Expires
- Mar 7, 2027
PAR-26-116 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 05, 2026 * | March 05, 2026 * | Not Applicable | July 2026 | October 2026 | December 2026 |
| February 05, 2027 * | March 05, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
What its predecessor PAR-21-343 funded
PAR-26-116 reissues PAR-21-343. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 13 projects and $20.5M in FY2022–FY2026.
Projects funded
13
Distinct projects, FY2022–FY2026
New awards
11
Type 1 (new project) award records
NIH funding
$20.5M
Award dollars under PAR-21-343, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 5 | 5 | $2.4M |
| FY2024 | 10 | 3 | $5.2M |
| FY2025 | 13 | 3 | $6.4M |
| FY2026 | 14 | 0 | $6.5M |
Institutions with the most funding
- Rutgers Biomedical and Health Sciences$3.2M · 2 projects
- Brigham and Women's Hospital$2.5M · 1 project
- Johns Hopkins University$2.1M · 1 project
- University of Southern California$2.0M · 1 project
- Beth Israel Deaconess Medical Center$1.9M · 1 project
- University of California, San Diego$1.8M · 1 project
- Northwestern University$1.5M · 1 project
- Indiana University Indianapolis$1.4M · 1 project
Funding institutes
- NCI$12.6M · 25
- NHLBI$4.4M · 10
- NICHD$2.1M · 4
- NIAID$1.3M · 3
Activity codes funded
- U0142 records
Most recent new awards
- Proton and hyperpolarized xenon pulmonary MRI at 0.55T (opens NIH RePORTER)
University of Virginia · 1U01HL178354-01 · NHLBI · Notice Aug 28, 2025
$660KU01
- Targeting mutant-MYOD1 driven rhabdomyosarcoma (opens NIH RePORTER)
Research Inst Nationwide Children's Hosp · 1U01CA298763-01 · NCI · Notice Jul 3, 2025
$481KU01
- Cell-Cell Signaling Driving HPV-Induced Respiratory Disease and Vaccine Response (opens NIH RePORTER)
Cincinnati Childrens Hosp Med Ctr · 1U01CA298630-01 · NCI · Notice Mar 27, 2025
$95KU01
- E7 TCR-T cell therapy for HPV-associated cancers (opens NIH RePORTER)
Rutgers Biomedical and Health Sciences · 1U01CA287904-01 · NCI · Notice Jun 26, 2024
$642KU01
- National Succinate Dehydrogenase-deficient GIST Translational Research and Clinical Trial Consortium (opens NIH RePORTER)
University of California, San Diego · 1U01CA278470-01A1 · NCI · Notice Mar 5, 2024
$550KU01
- Use of Tiered Genetic Sequencing and Specialty Referral for Identifying and Managing Rare Genetic Causes of Chronic Suppurative Respiratory Disease (opens NIH RePORTER)
Univ of North Carolina Chapel Hill · 1U01HL172658-01 · NHLBI · Notice Jan 15, 2024
$423KU01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
14 NIH institutes and offices take applications under PAR-26-116. Contact the program officer at the institute that fits your research before applying.
- OD · NIH Office of the Director
- NEI · National Eye Institute
- NHLBI · National Heart, Lung, and Blood Institute
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NIAID · National Institute of Allergy and Infectious Diseases
- NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCD · National Institute on Deafness and Other Communication Disorders
- NIDCR · National Institute of Dental and Craniofacial Research
- NIMH · National Institute of Mental Health
- NINDS · National Institute of Neurological Disorders and Stroke
- NCCIH · National Center for Complementary and Integrative Health
- NCI · National Cancer Institute
- ORWH
Related notices
NIH lists no related notices for PAR-26-116 yet.
Award terms
- Application types allowed
- New Renewal Resubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets need to reflect the actual needs of the proposed project. The maximum amount available per application is 500,000 direct costs per year; this amount includes extramural recipient costs, Clinical Center costs and intramural investigator's costs attributed to the proposed research project. The total of all three types of cost must not exceed 500,000 direct costs) per year.The…
- Project period
- The scope of the proposed project should determine the project period. For projects that do not need a planning year, the maximum project period is 4 years. If the project needs to include a planning year as part of the research plan, a fifth year can be proposed grant year 1) at a reduced budget level. NIH grants policies as described in the NIH Grants Policy Statement will apply to the…
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-21-343.
Other open NOFOs for U01
- RFA-NS-26-001Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)NINDS · next due Nov 10, 2026
- RFA-CA-27-019Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)NCI · next due Oct 19, 2026
- RFA-DE-27-001Community Engagement Evaluation and Data Coordination (CEED) Hub to Advance Data and Practice Transformation for Optimizing Oral Health for All (U01, Clinical Trial Not Allowed)NIDCR · next due Oct 19, 2026
- PAR-25-343NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders (U01 - Clinical Trial Required)NIDCD · next due Oct 19, 2026
- PAR-25-352National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U01 Clinical Trial Optional)NIMH · next due Oct 25, 2026
- RFA-HG-27-011GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed)NHGRI · next due Oct 30, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.