NIH PAR · NIDCR · U01
PAR-27-058: NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
This Notice of Funding Opportunity (NOFO) will support, through the cooperative agreement mechanism, investigator-initiated observational studies or biomarker validation studies that require prospective collection of data/biospecimens or continued analysis of data/biospecimens.
- NOFO number
- PAR-27-058
- Type
- PAR
- Activity code
- U01
- Primary institute
- NIDCR · National Institute of Dental and Craniofacial Research
- Clinical trials
- Not Allowed
- Posted
- Jun 16, 2026
- Opens
- Sep 5, 2026
- Expires
- Jul 6, 2029
PAR-27-058 due dates
8 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| October 05, 2026 * | November 05, 2026 * | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 05, 2027 * | March 05, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
| June 05, 2027 * | July 05, 2027 * | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 05, 2027 * | November 05, 2027 * | Not Applicable | March 2028 | May 2028 | July 2028 |
| February 05, 2028 * | March 05, 2028 * | Not Applicable | July 2028 | October 2028 | December 2028 |
| June 05, 2028 * | July 05, 2028 * | Not Applicable | November 2028 | January 2029 | April 2029 |
| October 05, 2028 * | November 05, 2028 * | Not Applicable | March 2029 | May 2029 | July 2029 |
| February 05, 2029 * | March 05, 2029 * | Not Applicable | July 2029 | October 2029 | December 2029 |
| June 05, 2029 * | July 05, 2029 * | Not Applicable | November 2029 | January 2030 | April 2030 |
What its predecessor PAR-25-239 funded
PAR-27-058 reissues PAR-25-239. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 4 projects and $3.6M in FY2022–FY2026.
Projects funded
4
Distinct projects, FY2022–FY2026
New awards
2
Type 1 (new project) award records
NIH funding
$3.6M
Award dollars under PAR-25-239, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 4 | 2 | $3.6M |
Institutions with the most funding
- University of Illinois at Chicago$1.3M · 1 project
- Johns Hopkins University$980K · 1 project
- Dartmouth College$791K · 1 project
- University of California, San Francisco$492K · 1 project
Funding institutes
- NIDCR$3.6M · 4
Activity codes funded
- R563 records
- U011 record
Most recent new awards
- Screening for HPV-related oropharyngeal cancer (opens NIH RePORTER)
Johns Hopkins University · 1R56DE036518-01 · NIDCR · Notice Sep 17, 2026
$980KR56
- Validating immune and epigenetic biomarkers of immunotherapy response in head and neck squamous cell carcinoma (opens NIH RePORTER)
Dartmouth College · 1U01DE036036-01 · NIDCR · Notice Jul 17, 2026
$791KU01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under PAR-27-058. Contact the program officer at the institute that fits your research before applying.
- NIDCR · National Institute of Dental and Craniofacial Research
- none
Related notices
NIH lists no related notices for PAR-27-058 yet.
Award terms
- Application types allowed
- New Renewal Resubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Up to 500,000 in direct costs per year.
- Project period
- A project duration of up to five years may be requested. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-25-239.
Other open NOFOs for U01
- RFA-DE-27-001Community Engagement Evaluation and Data Coordination (CEED) Hub to Advance Data and Practice Transformation for Optimizing Oral Health for All (U01, Clinical Trial Not Allowed)NIDCR · next due Oct 19, 2026
- PAR-27-057Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed)NIDCR · next due Feb 5, 2027
- PAR-26-116Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)OD · next due Feb 5, 2027
- RFA-CA-27-019Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)NCI · next due Oct 19, 2026
- PAR-25-343NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders (U01 - Clinical Trial Required)NIDCD · next due Oct 19, 2026
- PAR-25-352National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U01 Clinical Trial Optional)NIMH · next due Oct 25, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.