NIH PAR · NCI · U01

PAR-25-325: Integrating Biospecimen Science Approaches into Clinical Assay Development (U01 Clinical Trial Not Allowed)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Feb 4, 2027Expires Sep 11, 2027

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to support extramural research to investigate and mitigate challenges facing clinical assay development and subsequent analytical validation due to preanalytical variability in tumor tissue biopsies, blood biospecimens utilized as liquid biopsies", or other biospecimens as described in this NOFO. Extramural research funded under this NOFO may include investigations of preanalytical variability associated with the procurement and study of small biopsies (core biopsies, small excision samples), blood utilized for "liquid biopsies", tissue swabs, tissue secretions, pleural and esophageal aspirates,…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-325
Type
PAR
Activity code
U01
Primary institute
NCI · National Cancer Institute
Clinical trials
Not Allowed
Posted
Dec 13, 2024
Opens
Jan 4, 2025
Expires
Sep 11, 2027

PAR-25-325 due dates

3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-325
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 04, 2025February 04, 2025Not ApplicableJuly 2025October 2025December 2025
June 04, 2025June 04, 2025Not ApplicableNovember 2025January 2026April 2026
September 10, 2025September 10, 2025Not ApplicableMarch 2026May 2026July 2026
February 04, 2026February 04, 2026Not ApplicableJuly 2026October 2026December 2026
June 04, 2026June 04, 2026Not ApplicableNovember 2026January 2027April 2027
September 10, 2026September 10, 2026Not ApplicableMarch 2027May 2027July 2027
February 04, 2027February 04, 2027Not ApplicableJuly 2027October 2027December 2027
June 04, 2027June 04, 2027Not ApplicableNovember 2027January 2028April 2028
September 10, 2027September 10, 2027Not ApplicableMarch 2028May 2028July 2028

What its predecessor PAR-22-049 funded

PAR-25-325 reissues PAR-22-049. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 11 projects and $12.4M in FY2022–FY2026.

Projects funded

11

Distinct projects, FY2022–FY2026

New awards

11

Type 1 (new project) award records

NIH funding

$12.4M

Award dollars under PAR-22-049, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-22-049
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202344$1.5M
FY202484$2.9M
FY2025123$5.2M
FY202690$2.8M

Institutions with the most funding

  1. University of California, San Francisco$3.3M · 2 projects
  2. Ohio State University$1.8M · 1 project
  3. Baruch S. Blumberg Institute$1.5M · 1 project
  4. University of Washington$1.2M · 1 project
  5. Oregon Health & Science University$1.1M · 1 project
  6. Johns Hopkins University$1.0M · 1 project
  7. Indiana University Indianapolis$1.0M · 1 project
  8. Fred Hutchinson Cancer Center$846K · 1 project

Funding institutes

  • NCI$12.4M · 33

Activity codes funded

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-325. Contact the program officer at the institute that fits your research before applying.

  • NCI · National Cancer Institute
  • none

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Award terms

Application types allowed
NewRenewalResubmissionRevision Renewal The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are limited to 250,000 direct costs per year.
Project period
The maximum period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-22-049.

Other open NOFOs for U01

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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