NIH RFA · NCI · U01
RFA-CA-27-019: Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
This Notice of Funding Opportunity (NOFO) solicits applications for the development of enabling informatics technologies to improve the acquisition, management, analysis, and dissemination of data and knowledge across the cancer research continuum including cancer biology, cancer treatment and diagnosis, early cancer detection, risk assessment and prevention, cancer control and epidemiology. As a component of the NCI's Informatics Technology for Cancer Research (ITCR) Program, this NOFO is focused on early-stage development from prototyping to initial dissemination. Early-stage development is defined for the purpose of this NOFO as initial tool development or the significant modification of…
- NOFO number
- RFA-CA-27-019
- Type
- RFA
- Activity code
- U01
- Primary institute
- NCI · National Cancer Institute
- Clinical trials
- Optional
- Posted
- May 21, 2026
- Opens
- Jun 1, 2026
- Expires
- Oct 20, 2027
RFA-CA-27-019 due dates
3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| July 01, 2026 | July 01, 2026 | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 19, 2026 | October 19, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
| June 11, 2027 | June 11, 2027 | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 19, 2027 | October 19, 2027 | Not Applicable | March 2028 | May 2028 | July 2028 |
What its predecessor RFA-CA-24-017 funded
RFA-CA-27-019 reissues RFA-CA-24-017. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 6 projects and $4.5M in FY2022–FY2026.
Projects funded
6
Distinct projects, FY2022–FY2026
New awards
6
Type 1 (new project) award records
NIH funding
$4.5M
Award dollars under RFA-CA-24-017, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 4 | 4 | $1.6M |
| FY2026 | 6 | 2 | $2.8M |
Institutions with the most funding
- Baylor College of Medicine$1.2M · 1 project
- Univ of Massachusetts Med Sch Worcester$830K · 1 project
- Cornell University$814K · 1 project
- University of Wisconsin-Madison$783K · 1 project
- University of Tx MD Anderson Can Ctr$425K · 1 project
- New York University School of Medicine$422K · 1 project
Funding institutes
- NCI$4.5M · 10
Activity codes funded
- U0110 records
Most recent new awards
- Cancer Informatics Data Provenance with the Executive (opens NIH RePORTER)
New York University School of Medicine · 1U01CA294194-01A1 · NCI · Notice Sep 14, 2026
$422KU01
- Decipher dose accumulation for online adaptive radiotherapy (opens NIH RePORTER)
University of Tx MD Anderson Can Ctr · 1U01CA294088-01A1 · NCI · Notice Aug 31, 2026
$425KU01
- MEDUSA(GM): an analysis platform for resolving mechanisms of action for anti-cancer drugs (opens NIH RePORTER)
Univ of Massachusetts Med Sch Worcester · 1U01CA305435-01 · NCI · Notice Aug 6, 2025
$415KU01
- Image informatics tools for curation and prognostic modeling in pediatric brain tumors (opens NIH RePORTER)
University of Wisconsin-Madison · 1U01CA294415-01A1 · NCI · Notice Aug 5, 2025
$399KU01
- Deep learning based 3D network biology knowledge portal for precision oncology (opens NIH RePORTER)
Cornell University · 1U01CA294154-01A1 · NCI · Notice Aug 4, 2025
$414KU01
- Advancing Protein Isoform Analysis through an Integrated Computational Framework. (opens NIH RePORTER)
Baylor College of Medicine · 1U01CA299401-01 · NCI · Notice Jul 23, 2025
$398KU01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under RFA-CA-27-019. Contact the program officer at the institute that fits your research before applying.
- NCI · National Cancer Institute
- none
Related notices
NIH lists no related notices for RFA-CA-27-019 yet.
Award terms
- Application types allowed
- New Resubmission Revision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Budgets are limited to 300,000 Direct Costs excluding consortium F&A) per year.
- Project period
- The maximum project period is three years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- NCI intends to commit 2,400,000 in FY 2027 to fund an estimate of 5 awards. Future year amounts will depend on annual appropriations.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of RFA-CA-24-017.
- Companion NOFOs: RFA-CA-27-020, RFA-CA-27-021.
Other open NOFOs for U01
- PAR-25-325Integrating Biospecimen Science Approaches into Clinical Assay Development (U01 Clinical Trial Not Allowed)NCI · next due Feb 4, 2027
- PAR-28-056Pancreatic Cancer Detection Consortium: Research Units (U01 Clinical Trial Optional)NCI · next due Feb 5, 2027
- PAR-27-073Research Opportunities in Cancer Epidemiology Cohort Studies (U01 Clinical Trial Not Allowed)NCI · next due Feb 5, 2027
- PAR-25-248Utilizing the PLCO Biospecimens Resource to Bridge Gaps in Cancer Etiology and Early Detection Research (U01 Clinical Trial Not Allowed)NCI · next due Feb 10, 2027
- PAR-26-134The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed)NCI · next due Jun 5, 2027
- PAR-24-325Bioengineering Partnerships with Industry (U01 Clinical Trial Optional)NIBIB · next due Jan 27, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.