NIH PAR · NIMH · U01

PAR-25-352: National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U01 Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Oct 25, 2026Expires Oct 26, 2027

Reissue of PAR-20-118. This Notice of Funding Opportunity (NOFO) encourages applications to advance the discovery, preclinical development, and proof of concept (PoC) testing of new, rationally based candidate agents and neurostimulation approaches to treat mental disorders, substance use disorders (SUDs) or alcohol use disorder (AUD), and to develop novel ligands and circuit-engagement devices as tools to further characterize existing or to validate new drug/device targets. Partnerships between academia and industry are strongly encouraged. This NOFO using the U01 mechanism supports a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-352
Type
PAR
Activity code
U01
Primary institute
NIMH · National Institute of Mental Health
Clinical trials
Optional
Posted
Jan 15, 2025
Opens
Jan 25, 2025
Expires
Oct 26, 2027

PAR-25-352 due dates

4 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-352
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 25, 2025February 25, 2025Not ApplicableJuly 2025October 2025December 2025
June 25, 2025June 25, 2025Not ApplicableNovember 2025January 2026April 2026
October 25, 2025October 25, 2025Not ApplicableMarch 2026May 2026July 2026
February 25, 2026February 25, 2026Not ApplicableJuly 2026October 2026December 2026
June 25, 2026June 25, 2026Not ApplicableNovember 2026January 2027April 2027
October 25, 2026October 25, 2026Not ApplicableMarch 2027May 2027July 2027
February 25, 2027February 25, 2027Not ApplicableJuly 2027October 2027December 2027
June 25, 2027June 25, 2027Not ApplicableNovember 2027January 2028April 2028
October 25, 2027October 25, 2027Not ApplicableMarch 2028May 2028July 2028

What its predecessor PAR-22-143 funded

PAR-25-352 reissues PAR-22-143. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 1 project and $5.1M in FY2022–FY2026.

Projects funded

1

Distinct projects, FY2022–FY2026

New awards

1

Type 1 (new project) award records

NIH funding

$5.1M

Award dollars under PAR-22-143, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-22-143
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202411$1.5M
FY202510$1.8M
FY202610$1.8M

Institutions with the most funding

  1. University of Florida$5.1M · 1 project

Funding institutes

  • NIMH$5.1M · 3

Activity codes funded

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-352. Contact the program officer at the institute that fits your research before applying.

  • NIMH · National Institute of Mental Health
  • none

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Award terms

Application types allowed
NewRenewalResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are not limited but need to reflect the actual needs of the proposed project.
Project period
The total project period may not exceed five years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-22-143.
  • Companion NOFOs: PAR-25-353.

Other open NOFOs for U01

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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