NIH RFA · NIAID · U01
RFA-AI-27-014: Development of Candidate Medical Countermeasures (MCMs) and Technologies Against Radiological/Nuclear or Chemical Threats (U01 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of this notice of funding opportunity (NOFO) is to support research that advances understanding of the natural history of radiation or chemical exposures; develops relevant injury models; identifies and validates diagnostic tools, biomarkers, or triage technologies; and supports the development of effective medical countermeasures (MCMs) to mitigate or treat acute and/or delayed injuries resulting from radiological/nuclear or chemical public health emergencies.
- NOFO number
- RFA-AI-27-014
- Type
- RFA
- Activity code
- U01
- Primary institute
- NIAID · National Institute of Allergy and Infectious Diseases
- Clinical trials
- Not Allowed
- Posted
- Sep 1, 2026
- Opens
- Oct 9, 2026
- Expires
- Oct 10, 2028
RFA-AI-27-014 due dates
3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| November 09, 2026 | November 09, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
| October 08, 2027 | October 08, 2027 | Not Applicable | March 2028 | May 2028 | July 2028 |
| October 09, 2028 | October 09, 2028 | Not Applicable | March 2029 | May 2029 | July 2029 |
Funded projects
NIH RePORTER lists no awards under RFA-AI-27-014 in FY2022–FY2026, and it is a new NOFO rather than a reissue. Awards usually appear a few months after the first review cycle.
Participating institutes
6 NIH institutes and offices take applications under RFA-AI-27-014. Contact the program officer at the institute that fits your research before applying.
- NIAID · National Institute of Allergy and Infectious Diseases
- NEI · National Eye Institute
- NHLBI · National Heart, Lung, and Blood Institute
- NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
- NIDA · National Institute on Drug Abuse
- NINDS · National Institute of Neurological Disorders and Stroke
Related notices
NIH lists no related notices for RFA-AI-27-014 yet.
Award terms
- Application types allowed
- New Resubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not anticipated to exceed 350,000 in direct costs per year with the exception of application budgets for Research Area 3, which are not expected to exceed 2M in direct costs.All budgets should reflect the actual needs of the proposed project.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- NIAID intends to commit a total of 12M in FY 2027 to fund 18-20 awards in Research Areas 1, 2, and 4. There will be a total of 3M in FY2027 to fund one application in Research Area 3. The number of FY 2028 and 2029 awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Other open NOFOs for U01
- PAR-27-064NIAID Clinical Trial Implementation Cooperative Agreement (U01 Clinical Trial Required)NIAID · next due Feb 5, 2027
- PAR-26-116Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)OD · next due Feb 5, 2027
- RFA-CA-27-019Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)NCI · next due Oct 19, 2026
- RFA-DE-27-001Community Engagement Evaluation and Data Coordination (CEED) Hub to Advance Data and Practice Transformation for Optimizing Oral Health for All (U01, Clinical Trial Not Allowed)NIDCR · next due Oct 19, 2026
- PAR-25-343NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders (U01 - Clinical Trial Required)NIDCD · next due Oct 19, 2026
- PAR-25-352National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U01 Clinical Trial Optional)NIMH · next due Oct 25, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.