NIH PAR · NINDS · U01

PAR-25-327: Translational Efforts to Advance Gene-based Therapies for Ultra-Rare Neurological and Neuromuscular Disorders (U01 - Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Feb 9, 2027Expires Oct 9, 2027

The Ultra-Rare Gene-Based Therapy (URGenT) network supports Investigational New Drug (IND)-enabling studies and planning activities for First-in-Human (FIH) clinical testing of gene-based or transcript-directed therapeutics, such as oligonucleotides and viral-based gene therapies, for ultra-rare neurological or neuromuscular disorders. The goal of this announcement is to accelerate the development of a promising clinical candidate with robust biological rationale and demonstrated proof of concept (POC) data for the intended approach in a model system relevant to a specified patient population towards an IND filing and the initiation of a clinical trial.

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-327
Type
PAR
Activity code
U01
Primary institute
NINDS · National Institute of Neurological Disorders and Stroke
Clinical trials
Optional
Posted
Dec 18, 2024
Opens
Jan 9, 2025
Expires
Oct 9, 2027

PAR-25-327 due dates

3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-327
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 10, 2025February 10, 2025Not ApplicableJuly 2025October 2025December 2025
June 09, 2025June 09, 2025Not ApplicableNovember 2025January 2026April 2026
October 09, 2025October 09, 2025Not ApplicableMarch 2026May 2026July 2026
February 09, 2026February 09, 2026Not ApplicableJuly 2026October 2026December 2026
June 09, 2026June 09, 2026Not ApplicableNovember 2026January 2027April 2027
October 09, 2026October 09, 2026Not ApplicableMarch 2027May 2027July 2027
February 09, 2027February 09, 2027Not ApplicableJuly 2027October 2027December 2027
June 09, 2027June 09, 2027Not ApplicableNovember 2027January 2028April 2028
October 08, 2027October 08, 2027Not ApplicableMarch 2028May 2028July 2028

Projects funded under PAR-25-327

NIH RePORTER lists 4 projects funded under PAR-25-327 in FY2022–FY2026, with $5.4M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

4

Distinct projects, FY2022–FY2026

New awards

4

Type 1 (new project) award records

NIH funding

$5.4M

Award dollars under PAR-25-327, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-327
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202644$5.4M

Institutions with the most funding

  1. Massachusetts General Hospital$2.5M · 1 project
  2. University of Michigan at Ann Arbor$1.3M · 1 project
  3. Cedars-Sinai Medical Center$825K · 1 project
  4. University of California, San Francisco$650K · 1 project

Funding institutes

  • NINDS$5.4M · 4

Activity codes funded

Most recent new awards

What its predecessor PAR-22-030 funded

PAR-25-327 reissues PAR-22-030. Its funding history is the best guide to who wins under this program: 5 projects and $27.6M in FY2022–FY2026.

Projects funded

5

Distinct projects, FY2022–FY2026

New awards

5

Type 1 (new project) award records

NIH funding

$27.6M

Award dollars under PAR-22-030, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-22-030
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202333$1.8M
FY202442$8.3M
FY202540$9.5M
FY202620$7.9M

Institutions with the most funding

  1. Columbia University Health Sciences$17.5M · 2 projects
  2. University of Pennsylvania$6.0M · 1 project
  3. UT Southwestern Medical Center$2.1M · 1 project
  4. Broad Institute, Inc.$1.6M · 1 project
  5. Research Inst Nationwide Children's Hosp$376K · 1 project

Funding institutes

  • NINDS$27.6M · 13

Activity codes funded

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-327. Contact the program officer at the institute that fits your research before applying.

  • NINDS · National Institute of Neurological Disorders and Stroke
  • none

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy.

Award terms

Application types allowed
NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are not limited but need to reflect the actual needs of the proposed project.
Project period
The scope of the proposed project should determine the project period. The project period must not exceed 3 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-22-030.
  • Companion NOFOs: PAR-25-326.

Other open NOFOs for U01

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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