NIH PAR · NINDS · U01

PAR-25-149: Limited Competition: Renewal of Existing NINDS-Supported Clinical Trial Cooperative Agreement Awards (U01 - Clinical Trials Required)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Nov 5, 2026Expires Nov 6, 2027

This limited competition Notice of Funding Opportunity (NOFO) invites renewal applications of existing NINDS-supported clinical trial cooperative agreement awards (U01) requiring additional time and resources to complete the clinical trial.

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-149
Type
PAR
Activity code
U01
Primary institute
NINDS · National Institute of Neurological Disorders and Stroke
Clinical trials
Required
Posted
Oct 28, 2024
Opens
Feb 5, 2025
Expires
Nov 6, 2027

PAR-25-149 due dates

4 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-149
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
Not ApplicableMarch 05, 2025 *Not ApplicableJuly 2025October 2025December 2025
Not ApplicableJuly 05, 2025 *Not ApplicableNovember 2025January 2026April 2026
Not ApplicableNovember 05, 2025 *Not ApplicableMarch 2026May 2026July 2026
Not ApplicableMarch 05, 2026 *Not ApplicableJuly 2026October 2026December 2026
Not ApplicableJuly 05, 2026 *Not ApplicableNovember 2026January 2027April 2027
Not ApplicableNovember 05, 2026 *Not ApplicableMarch 2027May 2027July 2027
Not ApplicableMarch 05, 2027 *Not ApplicableJuly 2027October 2027December 2027
Not ApplicableJuly 05, 2027 *Not ApplicableNovember 2027January 2028April 2028
Not ApplicableNovember 05, 2027 *Not ApplicableMarch 2028May 2028July 2028

Projects funded under PAR-25-149

NIH RePORTER lists 2 projects funded under PAR-25-149 in FY2022–FY2026, with $7.3M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

2

Distinct projects, FY2022–FY2026

New awards

0

Type 1 (new project) award records

NIH funding

$7.3M

Award dollars under PAR-25-149, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-149
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202660$7.3M

Institutions with the most funding

  1. University of Michigan at Ann Arbor$4.1M · 1 project
  2. Northwestern University$3.1M · 1 project

Funding institutes

  • NINDS$7.3M · 6

Activity codes funded

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-149. Contact the program officer at the institute that fits your research before applying.

  • NINDS · National Institute of Neurological Disorders and Stroke
  • none

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy.

Award terms

Application types allowed
RenewalResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are not limited but need to reflect the actual needs of the proposed project.
Project period
The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Other open NOFOs for U01

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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