NIH RFA · NIDA · U01
RFA-DA-28-013: Neural Ensembles & Used Substances (NExUS) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances (U01 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The National Institute on Drug Abuse (NIDA) invites applications to renew and expand the Collaboratory on Neural Ensembles and Used Substances (NExUS). NExUS is a collaborative research program to decode how substance use experiences and addictive neurobehavioral states are represented in the brain at the level of cell populations. This funding opportunity seeks applications that propose systematic and scalable methods to identify, map, and analyze groups of neurons that respond to used substances. The goal is to create a comprehensive, multimodal database and use it to test hypotheses about how specific neural population activity patterns relate to behavioral states associated with…
- NOFO number
- RFA-DA-28-013
- Type
- RFA
- Activity code
- U01
- Primary institute
- NIDA · National Institute on Drug Abuse
- Clinical trials
- Not Allowed
- Posted
- Oct 9, 2026
- Opens
- Jan 8, 2027
- Expires
- Feb 9, 2027
RFA-DA-28-013 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 08, 2027 | February 08, 2027 | Not Applicable | July 2027 | October 2027 | December 2027 |
What its predecessor RFA-DA-25-023 funded
RFA-DA-28-013 reissues RFA-DA-25-023. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 2 projects and $4.3M in FY2022–FY2026.
Projects funded
2
Distinct projects, FY2022–FY2026
New awards
2
Type 1 (new project) award records
NIH funding
$4.3M
Award dollars under RFA-DA-25-023, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 2 | 2 | $2.2M |
| FY2026 | 2 | 0 | $2.1M |
Institutions with the most funding
- Vanderbilt University$2.3M · 1 project
- Medical University of South Carolina$2.0M · 1 project
Funding institutes
- NIDA$4.3M · 4
Activity codes funded
- R014 records
Most recent new awards
- Molecular determinants of ensemble recruitment by drugs of abuse (opens NIH RePORTER)
Vanderbilt University · 1R01DA062024-01 · NIDA · Notice Jun 26, 2025
$1.2MR01
- Multiplexed dissection of neuronal ensembles in circuits that underlie the facilitation and disinhibition of opioid and alcohol seeking (opens NIH RePORTER)
Medical University of South Carolina · 1R01DA062041-01 · NIDA · Notice May 29, 2025
$1.0MR01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under RFA-DA-28-013. Contact the program officer at the institute that fits your research before applying.
- NIDA · National Institute on Drug Abuse
- none
Related notices
NIH lists no related notices for RFA-DA-28-013 yet.
Award terms
- Application types allowed
- New Renewal Resubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Applications may not request more than 700,000 direct costs for any one year.
- Project period
- The maximum project period is five years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- NIDA intends to commit 4M in FY2027 to fund multiple projects, including at least one project emphasizing informatics, data integration and consortium coordination goals.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of RFA-DA-25-023.
Other open NOFOs for U01
- PAR-24-269NIDA Animal Genomics Program (U01 Clinical Trial Not Allowed)NIDA
- RFA-AI-27-014Development of Candidate Medical Countermeasures (MCMs) and Technologies Against Radiological/Nuclear or Chemical Threats (U01 Clinical Trial Not Allowed)NIAID · next due Nov 9, 2026
- RFA-NS-27-015BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)NINDS · next due Feb 8, 2027
- RFA-MH-26-140BRAIN Initiative: Brain Behavior Quantification and Synchronization- Next Generation Sensor Technology Development (U01 Clinical Trial Optional)NIMH · next due Jun 15, 2027
- RFA-CA-27-019Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)NCI · next due Oct 19, 2026
- RFA-DE-27-001Community Engagement Evaluation and Data Coordination (CEED) Hub to Advance Data and Practice Transformation for Optimizing Oral Health for All (U01, Clinical Trial Not Allowed)NIDCR · next due Oct 19, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.