NIH PAR · NINDS · UG3, UH3

PAR-27-065: NINDS Efficacy and Exploratory Clinical Trials (UG3/UH3 - Clinical Trial Required)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Nov 9, 2026Expires Mar 10, 2029

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated clinical trials to the National Institute of Neurological Disorders and Stroke (NINDS). These trials must address questions within the mission and research interests of the NINDS and may include studies of small molecules, biologics, devices as well as surgical, behavioral, diet-based, or rehabilitation therapies. Studies addressing neurological diseases and care across the lifespan are highly encouraged. This notice invites both early- and middle-phase exploratory clinical trials as well as later phase confirmatory Phase 3 or comparative effectiveness clinical trials.

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-27-065
Type
PAR
Activity code
UG3UH3
Primary institute
NINDS · National Institute of Neurological Disorders and Stroke
Clinical trials
Required
Posted
Aug 31, 2026
Opens
Oct 9, 2026
Expires
Mar 10, 2029

PAR-27-065 due dates

8 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-27-065
NewRenewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
November 09, 2026November 09, 2026Not ApplicableMarch 2027May 2027July 2027
February 10, 2027March 10, 2027Not ApplicableJuly 2027October 2027December 2027
June 10, 2027July 09, 2027Not ApplicableNovember 2027January 2028April 2028
October 08, 2027November 08, 2027Not ApplicableMarch 2028May 2028July 2028
February 10, 2028March 10, 2028Not ApplicableJuly 2028October 2028December 2028
June 09, 2028July 10, 2028Not ApplicableNovember 2028January 2029April 2029
October 10, 2028November 09, 2028Not ApplicableMarch 2029May 2029July 2029
February 09, 2029March 09, 2029Not ApplicableJuly 2029October 2029December 2029

What its predecessor PAR-25-054 funded

PAR-27-065 reissues PAR-25-054. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 5 projects and $6.8M in FY2022–FY2026.

Projects funded

5

Distinct projects, FY2022–FY2026

New awards

5

Type 1 (new project) award records

NIH funding

$6.8M

Award dollars under PAR-25-054, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-054
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202655$6.8M

Institutions with the most funding

  1. Yale University$3.3M · 1 project
  2. Stanford University$1.4M · 1 project
  3. University of Minnesota$770K · 1 project
  4. Mayo Clinic Rochester$713K · 1 project
  5. University of Alabama at Birmingham$557K · 1 project

Funding institutes

  • NINDS$6.8M · 5

Activity codes funded

  • UG35 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-27-065. Contact the program officer at the institute that fits your research before applying.

  • NINDS · National Institute of Neurological Disorders and Stroke
  • none

Related notices

NIH lists no related notices for PAR-27-065 yet.

Award terms

Application types allowed
New Resubmission Revision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are not limited but need to reflect the actual needs of the proposed project.
Project period
The UG3 period may not exceed 2 years. The maximum project period of both phases may not exceed 7 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-25-054.

Other open NOFOs for UG3, UH3

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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