NIH PAR · NIDCR · UG3, UH3
PAR-25-188: NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of this Notice of Funding Opportunity (NOFO) is to encourage UG3/UH3 phased cooperative agreement research applications to plan and implement behavioral and social intervention clinical trials. Studies appropriate for this announcement include clinical trials to develop and test behavior change interventions related to dental, oral, or craniofacial conditions. Awards made under this FOA will initially support a milestone-driven planning phase (UG3) for up to 2 years, with possible transition to a clinical trial implementation phase (UH3) of up to five years. Only UG3 projects that have met the scientific milestones and feasibility requirements may transition to the UH3 phase.…
- NOFO number
- PAR-25-188
- Type
- PAR
- Activity code
- UG3UH3
- Primary institute
- NIDCR · National Institute of Dental and Craniofacial Research
- Clinical trials
- Required
- Posted
- Dec 2, 2024
- Opens
- Jan 7, 2025
- Expires
- Jan 7, 2028
PAR-25-188 due dates
3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 07, 2025 | March 07, 2025 | May 08, 2025 | July 2025 | October 2025 | December 2025 |
| June 06, 2025 | July 08, 2025 | September 04, 2025 | November 2025 | January 2026 | April 2026 |
| October 07, 2025 | November 06, 2025 | January 06, 2026 | March 2026 | May 2026 | July 2026 |
| February 09, 2026 | March 09, 2026 | May 8, 2026 | July 2026 | October 2026 | December 2026 |
| June 08, 2026 | July 08, 2026 | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 08, 2026 | November 09, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 08, 2027 | March 08, 2027 | Not Applicable | July 2027 | October 2027 | December 2027 |
| June 08, 2027 | July 07, 2027 | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 08, 2027 | November 08, 2027 | Not Applicable | March 2028 | May 2028 | July 2028 |
Projects funded under PAR-25-188
NIH RePORTER lists 1 project funded under PAR-25-188 in FY2022–FY2026, with $822K in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
1
Distinct projects, FY2022–FY2026
New awards
1
Type 1 (new project) award records
NIH funding
$822K
Award dollars under PAR-25-188, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 1 | 1 | $822K |
Institutions with the most funding
- University of Texas Hlth Sci Ctr Houston$822K · 1 project
Funding institutes
- NIDCR$822K · 1
Activity codes funded
- UG31 record
Most recent new awards
- SmartMouth: Nudging Dentists Towards Evidence-based Pain Management (opens NIH RePORTER)
University of Texas Hlth Sci Ctr Houston · 1UG3DE034676-01A1 · NIDCR · Notice Sep 8, 2026
$822KUG3
What its predecessor PAR-21-317 funded
PAR-25-188 reissues PAR-21-317. Its funding history is the best guide to who wins under this program: 9 projects and $10.1M in FY2022–FY2026.
Projects funded
9
Distinct projects, FY2022–FY2026
New awards
5
Type 1 (new project) award records
NIH funding
$10.1M
Award dollars under PAR-21-317, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 3 | 3 | $1.0M |
| FY2023 | 5 | 1 | $1.3M |
| FY2024 | 3 | 0 | $1.8M |
| FY2025 | 5 | 1 | $3.4M |
| FY2026 | 4 | 0 | $2.6M |
Institutions with the most funding
- University of Illinois at Chicago$3.0M · 2 projects
- University of Florida$2.8M · 2 projects
- Georgetown University$2.2M · 2 projects
- Healthpartners Institute$1.5M · 2 projects
- Vanderbilt University$646K · 1 project
Funding institutes
- NIDCR$10.1M · 20
Activity codes funded
- UG311 records
- UH39 records
Most recent new awards
- Caregiver-implemented early speech and language intervention for toddlers with cleft palate (opens NIH RePORTER)
Vanderbilt University · 1UG3DE035073-01 · NIDCR · Notice Sep 2, 2025
$337KUG3
- Investigating Behavioral Mechanisms and Efficacy of a Provider-Directed Intervention for HPV Vaccine Promotion in Real-World Dental Settings (opens NIH RePORTER)
Healthpartners Institute · 1UG3DE030063-01A1 · NIDCR · Notice Jan 26, 2023
$316KUG3
- Implementing Evidence-based Behavioral Skills in Pediatric Oral Healthcare Providers (opens NIH RePORTER)
University of Florida · 1UG3DE032004-01 · NIDCR · Notice Sep 20, 2022
$353KUG3
- Testing a Multi-behavioral Intervention to Improve Oral Health Behaviors in the Pediatric Dental Surgery Population (opens NIH RePORTER)
University of Illinois at Chicago · 1UG3DE032003-01 · NIDCR · Notice Sep 20, 2022
$332KUG3
- Use of a decision aid to resolve uncertainty about radioactive iodine treatment in patients with intermediate-risk thyroid cancer: the Radiance trial (opens NIH RePORTER)
Georgetown University · 1UG3DE031248-01A1 · NIDCR · Notice Sep 5, 2022
$341KUG3
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under PAR-25-188. Contact the program officer at the institute that fits your research before applying.
- NIDCR · National Institute of Dental and Craniofacial Research
- none
Related notices
Jan 28, 2026 · NOT-OD-26-029
NIH Removing AIDS Application Due Dates from NOFOs.
Mar 31, 2025
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.
Oct 10, 2024 · NOT-OD-24-084
Continuation or Revision of NIDCR Clinical Trial Implementation Cooperative Agreement UH3 Clinical Trial Required). See NOFO PAR-25-062.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025.
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Notices of Special Interest (NOSIs)
NIH has attached 9 NOSIs to PAR-25-188; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.
Award terms
- Application types allowed
- NewResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited but need to reflect the actual needs of the proposed project.If the budget exceeds direct costs of 500,000 or more in any year, applicants must follow the NIDCR policy for Grant Applications Requesting 500,000 or More in Direct Costs for Any Project Year.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 1 year for the UG3 phase and 5 years for the UH3 phase. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-21-317.
Other open NOFOs for UG3, UH3
- PAR-27-015Community-Based Participatory Research to Advance Data and Practice Transformation (ADAPT) for Optimizing Oral Health for All (UG3/UH3 Clinical Trial Optional)NIDCR · next due Oct 16, 2026
- PAR-25-062Continuation or Revision of NIDCR Clinical Trial Planning and Implementation Cooperative Agreement (UH3 Clinical Trial Required)NIDCR · next due Nov 9, 2026
- PAR-25-057NIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)NIDCR · next due Feb 8, 2027
- PAR-25-296Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative and Innovative Acceleration Award (UG3/UH3 Clinical Trial Optional)NCATS · next due Oct 19, 2026
- PAR-24-293Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional)NINDS · next due Jan 15, 2027
- PAR-25-383Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional)NINDS · next due Jan 28, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.