NIH PAR · NIDCR · UG3, UH3

PAR-25-057: NIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Feb 8, 2027Expires Jan 7, 2028

To support UG3/UH3 phased, cooperative agreement research applications to plan and implement clinical trials within the mission of the National Institute of Dental and Craniofacial Research (NIDCR)

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-057
Type
PAR
Activity code
UG3UH3
Primary institute
NIDCR · National Institute of Dental and Craniofacial Research
Clinical trials
Required
Posted
Oct 23, 2024
Opens
Jan 7, 2025
Expires
Jan 7, 2028

PAR-25-057 due dates

3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-057
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 07, 2025March 07, 2025May 08, 2025July 2025October 2025December 2025
June 06, 2025July 07, 2025September 04, 2025November 2025January 2026April 2026
October 07, 2025November 06, 2025January 06, 2026March 2026May 2026July 2026
February 09, 2026March 09, 2026May 8, 2026July 2026October 2026December 2026
June 08, 2026July 08, 2026Not ApplicableNovember 2026January 2027April 2027
October 08, 2026November 09, 2026Not ApplicableMarch 2027May 2027July 2027
February 08, 2027March 08, 2027Not ApplicableJuly 2027October 2027December 2027
June 07, 2027July 07, 2027Not ApplicableNovember 2027January 2028April 2028
October 07, 2027November 08, 2027Not ApplicableMarch 2028May 2028July 2028

Projects funded under PAR-25-057

NIH RePORTER lists 3 projects funded under PAR-25-057 in FY2022–FY2026, with $1.7M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

3

Distinct projects, FY2022–FY2026

New awards

3

Type 1 (new project) award records

NIH funding

$1.7M

Award dollars under PAR-25-057, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-057
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202633$1.7M

Institutions with the most funding

  1. University of California, San Francisco$1.1M · 2 projects
  2. Mayo Clinic Rochester$576K · 1 project

Funding institutes

  • NIDCR$1.7M · 3

Activity codes funded

  • UG33 records

Most recent new awards

What its predecessor PAR-21-160 funded

PAR-25-057 reissues PAR-21-160. Its funding history is the best guide to who wins under this program: 10 projects and $9.1M in FY2022–FY2026.

Projects funded

10

Distinct projects, FY2022–FY2026

New awards

5

Type 1 (new project) award records

NIH funding

$9.1M

Award dollars under PAR-21-160, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-21-160
Fiscal yearAward recordsNew awardsFunding
FY202211$559K
FY202310$714K
FY202421$1.0M
FY202553$2.8M
FY202660$4.1M

Institutions with the most funding

  1. University of Florida$3.4M · 2 projects
  2. Univ of North Carolina Chapel Hill$2.4M · 4 projects
  3. Wake Forest University Health Sciences$2.3M · 2 projects
  4. Rise Therapeutics, LLC$979K · 2 projects

Funding institutes

  • NIDCR$9.1M · 15

Activity codes funded

  • UH310 records
  • UG35 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-057. Contact the program officer at the institute that fits your research before applying.

  • NIDCR · National Institute of Dental and Craniofacial Research
  • none

Related notices

  1. Jan 28, 2026 · NOT-OD-26-029

    NIH Removing AIDS Application Due Dates from NOFOs.

  2. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  3. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  4. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Notices of Special Interest (NOSIs)

NIH has attached 11 NOSIs to PAR-25-057; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.

Award terms

Application types allowed
NewResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are limited to less than 400,000 in direct costs for the UG3 phase; Application budgets for the UH3 phase are not limited but need to reflect the actual needs of the proposed project.If the budget exceeds direct costs of 500,000 or more in any year, applicants must follow the NIDCR policy for Grant Applications Requesting 500,000 or More in Direct Costs for Any Project Year.
Project period
The total project period may not exceed one year for the UG3 phase and five years for the UH3 phase. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-21-160.

Other open NOFOs for UG3, UH3

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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