NIH PAR · NINDS · UG3, UH3

PAR-24-293: Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Jan 15, 2027Expires Aug 19, 2027

The Blueprint Neurotherapeutics Network for Biologics (BPN-Biologics) provides support for biologic-based therapeutic discovery and development, from lead optimization through phase I clinical testing. This Funding Opportunity Announcement (FOA) supports preclinical discovery and development of potential therapeutic Biotechnology Products and Biologics including, but not limited to, large biologic macromolecules, (e.g., proteins, antibodies, and peptides), gene-based therapies (i.e., oligonucleotide- and viral-based), cell therapies, and novel emerging therapies (e.g., microbial and microbiome therapies). Applicants will collaborate with NIH-funded consultants and can augment their project…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-24-293
Type
PAR
Activity code
UG3UH3
Primary institute
NINDS · National Institute of Neurological Disorders and Stroke
Clinical trials
Optional
Posted
Oct 1, 2024
Opens
Dec 27, 2024
Expires
Aug 19, 2027

PAR-24-293 due dates

2 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-24-293
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
January 27, 2025January 27, 2025April 18, 2025July 2025October 2025December 2025
July 15, 2025July 15, 2025August 18, 2025November 2025January 2026April 2026
January 15, 2026January 15, 2026April 17, 2026July 2026October 2026December 2026
July 15, 2026July 15, 2026Not ApplicableNovember 2026January 2027April 2027
January 15, 2027January 15, 2027Not ApplicableJuly 2027October 2027December 2027
July 15, 2027July 15, 2027Not ApplicableNovember 2027January 2028April 2028

Projects funded under PAR-24-293

NIH RePORTER lists 3 projects funded under PAR-24-293 in FY2022–FY2026, with $2.6M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

3

Distinct projects, FY2022–FY2026

New awards

3

Type 1 (new project) award records

NIH funding

$2.6M

Award dollars under PAR-24-293, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-24-293
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202633$2.6M

Institutions with the most funding

  1. Univ of Massachusetts Med Sch Worcester$1.0M · 1 project
  2. Brigham and Women's Hospital$790K · 1 project
  3. Johns Hopkins University$750K · 1 project

Funding institutes

  • NINDS$2.6M · 3

Activity codes funded

  • UG33 records

Most recent new awards

What its predecessor PAR-21-163 funded

PAR-24-293 reissues PAR-21-163. Its funding history is the best guide to who wins under this program: 9 projects and $8.4M in FY2022–FY2026.

Projects funded

9

Distinct projects, FY2022–FY2026

New awards

6

Type 1 (new project) award records

NIH funding

$8.4M

Award dollars under PAR-21-163, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-21-163
Fiscal yearAward recordsNew awardsFunding
FY202211$1.5M
FY202332$1.8M
FY202432$1.9M
FY202531$2.7M
FY202610$470K

Institutions with the most funding

  1. Northwestern University$2.7M · 2 projects
  2. University of Florida$1.6M · 2 projects
  3. Univ of North Carolina Chapel Hill$1.5M · 1 project
  4. Rutgers Biomedical and Health Sciences$1.3M · 2 projects
  5. University of California, San Diego$777K · 1 project
  6. University of Pennsylvania$491K · 1 project

Funding institutes

  • NINDS$8.4M · 11

Activity codes funded

  • UG38 records
  • UH33 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

10 NIH institutes and offices take applications under PAR-24-293. Contact the program officer at the institute that fits your research before applying.

  • NINDS · National Institute of Neurological Disorders and Stroke
  • NEI · National Eye Institute
  • NIA · National Institute on Aging
  • NIAAA · National Institute on Alcohol Abuse and Alcoholism
  • NIDCR · National Institute of Dental and Craniofacial Research
  • NIDA · National Institute on Drug Abuse
  • NIEHS · National Institute of Environmental Health Sciences
  • NIMH · National Institute of Mental Health
  • NCCIH · National Center for Complementary and Integrative Health
  • OBSSR

Related notices

  1. Jan 28, 2026 · NOT-OD-26-029

    NIH Removing AIDS Application Due Dates from NOFOs.

  2. May 8, 2025 · NOT-NS-25-024

    Notice of Change: Expiration of RFA-NS-24-019: HEAL Initiative: Non-addictive Analgesic Therapeutics Development Small Molecules and Biologics] to Treat Pain UG3/UH3 Clinical Trial Optional). See Notice NOT-NS-25-024. 

  3. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  4. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  5. Aug 5, 2022

    Implementation Details for the NIH Data Management and Sharing Policy.

Award terms

Application types allowed
NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are not limited but need to reflect the actual needs of the proposed project.
Project period
Applicants may seek up to two years of UG3 funding. The UH3 phase cannot exceed four years. The total duration of both the UG3 and UH3 cannot exceed 5 years. The actual duration of individual projects will depend upon the entry point and on successful achievement of milestones and conditions as described in Milestones Section of the program overview. NIH grants policies as described in the NIH…
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-21-163.
  • Companion NOFOs: PAR-24-294.

Other open NOFOs for UG3, UH3

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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