NIH PAR · NHLBI · UG3, UH3

PAR-27-012: Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Feb 1, 2027Expires Nov 3, 2028

This Notice of Funding Opportunity (NOFO) supports applications to develop and conduct a Clinical Coordinating Center (CCC) for investigator-initiated multi-site clinical trials including efficacy, comparative effectiveness, pragmatic and/or dissemination and implementation science clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. These trials may include ones that test different therapeutic, behavioral, dissemination and implementation science clinical trials and/or prevention strategies.Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-27-012
Type
PAR
Activity code
UG3UH3
Primary institute
NHLBI · National Heart, Lung, and Blood Institute
Clinical trials
Required
Posted
Mar 18, 2026
Opens
May 2, 2026
Expires
Nov 3, 2028

PAR-27-012 due dates

6 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-27-012
NewRenewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
June 02, 2026July 02, 2026Not ApplicableNovember 2026January 2027April 2027
October 02, 2026November 02, 2026Not ApplicableMarch 2027May 2027July 2027
February 01, 2027March 01, 2027Not ApplicableJuly 2027October 2027December 2027
June 02, 2027July 02, 2027Not ApplicableNovember 2027January 2028April 2028
October 01, 2027November 01, 2027Not ApplicableMarch 2028May 2028July 2028
February 01, 2028March 01, 2028Not ApplicableJuly 2028October 2028December 2028
June 01, 2028June 30, 2028Not ApplicableNovember 2028January 2029April 2029
October 02, 2028November 02, 2028Not ApplicableMarch 2029May 2029July 2029

What its predecessor PAR-25-029 funded

PAR-27-012 reissues PAR-25-029. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 6 projects and $8.4M in FY2022–FY2026.

Projects funded

6

Distinct projects, FY2022–FY2026

New awards

6

Type 1 (new project) award records

NIH funding

$8.4M

Award dollars under PAR-25-029, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-029
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY2026196$8.4M

Institutions with the most funding

  1. National Jewish Health$3.1M · 2 projects
  2. University of Alabama at Birmingham$2.2M · 1 project
  3. Icahn School of Medicine at Mount Sinai$1.8M · 2 projects
  4. Ihc Health Services, Inc.$1.3M · 1 project

Funding institutes

  • NHLBI$8.4M · 19

Activity codes funded

  • UG319 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-27-012. Contact the program officer at the institute that fits your research before applying.

  • NHLBI · National Heart, Lung, and Blood Institute
  • none

Related notices

NIH lists no related notices for PAR-27-012 yet.

Award terms

Application types allowed
New Resubmission Revision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are not limited but need to reflect the actual needs of the proposed project.
Project period
The scope of the proposed project should determine the requested project award period.The project period for the UG3 phase will be up to 1 year.The project period for the UH3 phase is expected to be 4 years. With strong justification, up to 6 years for the UH3 may be requested. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards…
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-25-029.
  • Companion NOFOs: PAR-27-013.

Other open NOFOs for UG3, UH3

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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