NIH PAR · NINDS · UG3, UH3

PAR-25-383: Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Jan 28, 2027Expires Jan 29, 2028

The purpose of this announcement is to encourage investigators to pursue translational activities and clinical feasibility studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, as well as a subsequent clinical feasibility study. The clinical study is expected to…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-383
Type
PAR
Activity code
UG3UH3
Primary institute
NINDS · National Institute of Neurological Disorders and Stroke
Clinical trials
Optional
Posted
Jun 17, 2025
Opens
Aug 29, 2025
Expires
Jan 29, 2028

PAR-25-383 due dates

4 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-383
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
September 29, 2025September 29, 2025Not ApplicableMarch 2026May 2026July 2026
January 28, 2026January 28, 2026Not ApplicableJuly 2026October 2026December 2026
May 28, 2026May 28, 2026Not ApplicableNovember 2026January 2027April 2027
September 28, 2026September 28, 2026Not ApplicableMarch 2027May 2027July 2027
January 28, 2027January 28, 2027Not ApplicableJuly 2027October 2027December 2027
May 28, 2027May 28, 2027Not ApplicableNovember 2027January 2028April 2028
September 28, 2027September 28, 2027Not ApplicableMarch 2028May 2028July 2028
January 28, 2028January 28, 2028Not ApplicableJuly 2028October 2028December 2028

Projects funded under PAR-25-383

NIH RePORTER lists 4 projects funded under PAR-25-383 in FY2022–FY2026, with $3.9M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

4

Distinct projects, FY2022–FY2026

New awards

4

Type 1 (new project) award records

NIH funding

$3.9M

Award dollars under PAR-25-383, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-383
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202644$3.9M

Institutions with the most funding

  1. Duke University$1.4M · 1 project
  2. Case Western Reserve University$1.2M · 1 project
  3. University of California, San Francisco$678K · 1 project
  4. University of Florida$613K · 1 project

Funding institutes

  • NINDS$3.9M · 4

Activity codes funded

  • UG34 records

Most recent new awards

What its predecessor PAR-21-315 funded

PAR-25-383 reissues PAR-21-315. Its funding history is the best guide to who wins under this program: 10 projects and $14.1M in FY2022–FY2026.

Projects funded

10

Distinct projects, FY2022–FY2026

New awards

7

Type 1 (new project) award records

NIH funding

$14.1M

Award dollars under PAR-21-315, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-21-315
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202322$4.6M
FY202421$1.9M
FY202543$5.1M
FY202641$2.5M

Institutions with the most funding

  1. Vanderbilt University Medical Center$4.4M · 1 project
  2. University of Pittsburgh at Pittsburgh$3.2M · 1 project
  3. University of Texas Hlth Sci Ctr Houston$2.4M · 2 projects
  4. Rhaeos, Inc.$1.4M · 2 projects
  5. University of Louisville$1.1M · 2 projects
  6. Columbia University Health Sciences$953K · 1 project
  7. Massachusetts General Hospital$676K · 1 project

Funding institutes

  • NINDS$13.4M · 11
  • NIDA$676K · 1

Activity codes funded

  • UG38 records
  • UH34 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

11 NIH institutes and offices take applications under PAR-25-383. Contact the program officer at the institute that fits your research before applying.

  • NINDS · National Institute of Neurological Disorders and Stroke
  • NEI · National Eye Institute
  • NIA · National Institute on Aging
  • NIAAA · National Institute on Alcohol Abuse and Alcoholism
  • NIBIB · National Institute of Biomedical Imaging and Bioengineering
  • NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • NIDCR · National Institute of Dental and Craniofacial Research
  • NIDA · National Institute on Drug Abuse
  • NIMH · National Institute of Mental Health
  • NCCIH · National Center for Complementary and Integrative Health
  • OBSSR

Related notices

  1. Aug 8, 2024 · NOT-OD-24-084

    Notice of Special Interest NOSI): HEAL Initiative: Development and Translation of Diagnostic and Therapeutic Devices via Blueprint MedTech See Notice NOT-NS-24-075April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025.

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Notices of Special Interest (NOSIs)

NIH has attached 1 NOSI to PAR-25-383; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.

Award terms

Application types allowed
NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are not limited but need to reflect the actual needs of the proposed project.In all cases, applicants should propose a budget that is reasonable and appropriate for completion of the research project. Application budgets should only cover the work that will be performed by the PD/PI and his/her staff. The NIH will pay Blueprint MedTech contractors and consultants directly for…
Project period
The proposed project period for the UG3 phase must not exceed 4 years.The proposed project period for the UH3 phase must not exceed 4 years.The proposed total duration of the UG3 and UH3 may not exceed 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. 

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-21-315.

Other open NOFOs for UG3, UH3

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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