NIH PAR · NIGMS · R01

PAR-25-203: Focused Technology Research and Development (R01 Clinical Trial Not Allowed)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Feb 5, 2027Expires Jan 8, 2028

This Notice of Funding Opportunity (NOFO) supports projects relevant to the NIGMS mission that focus solely on the development of technologies with potential to enable acquisition of biomedical knowledge. Projects should be justified in terms of technical innovation and utility of such technical innovation for impacting future biomedical research. Outcomes or products of the proposed project should significantly advance the current state of the art and be sufficiently characterized for application in addressing a broad range of biomedical research questions.

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-203
Type
PAR
Activity code
R01
Primary institute
NIGMS · National Institute of General Medical Sciences
Clinical trials
Not Allowed
Posted
Nov 14, 2024
Opens
Jan 5, 2025
Expires
Jan 8, 2028

PAR-25-203 due dates

3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-203
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 05, 2025March 05, 2025 *May 07, 2025 *July 2025October 2025December 2025
June 05, 2025July 05, 2025 *September 07, 2025 *November 2025January 2026April 2026
October 05, 2025November 05, 2025 *January 07, 2026 *March 2026May 2026July 2026
February 05, 2026March 05, 2026 *May 07, 2026 *July 2026October 2026December 2026
June 05, 2026July 05, 2026 *Not ApplicableNovember 2026January 2027April 2027
October 05, 2026November 05, 2026 *Not ApplicableMarch 2027May 2027July 2027
February 05, 2027March 05, 2027 *Not ApplicableJuly 2027October 2027December 2027
June 05, 2027July 05, 2027 *Not ApplicableNovember 2027January 2028April 2028
October 05, 2027November 05, 2027 *Not ApplicableMarch 2028May 2028July 2028

Projects funded under PAR-25-203

NIH RePORTER lists 37 projects funded under PAR-25-203 in FY2022–FY2026, with $51.3M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

37

Distinct projects, FY2022–FY2026

New awards

33

Type 1 (new project) award records

NIH funding

$51.3M

Award dollars under PAR-25-203, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-203
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY20263733$51.3M

Institutions with the most funding

  1. University of Washington$7.3M · 4 projects
  2. University of Chicago$4.2M · 2 projects
  3. Stanford University$4.0M · 3 projects
  4. Battelle Pacific Northwest Laboratories$2.8M · 1 project
  5. University of California, San Diego$2.4M · 2 projects
  6. Seattle Children's Hospital$2.1M · 1 project
  7. Yale University$2.0M · 1 project
  8. Univ of Massachusetts Med Sch Worcester$2.0M · 1 project

Funding institutes

  • NIGMS$51.3M · 37

Activity codes funded

Most recent new awards

What its predecessor PAR-22-127 funded

PAR-25-203 reissues PAR-22-127. Its funding history is the best guide to who wins under this program: 77 projects and $103.5M in FY2022–FY2026.

Projects funded

77

Distinct projects, FY2022–FY2026

New awards

68

Type 1 (new project) award records

NIH funding

$103.5M

Award dollars under PAR-22-127, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-22-127
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY20232723$12.7M
FY20244821$19.2M
FY20257321$43.2M
FY2026653$28.4M

Institutions with the most funding

  1. Yale University$4.1M · 3 projects
  2. University of California, San Francisco$4.0M · 2 projects
  3. Univ of North Carolina Chapel Hill$3.5M · 2 projects
  4. Boston University (Charles River Campus)$3.4M · 2 projects
  5. Massachusetts Institute of Technology$3.2M · 2 projects
  6. University of California-Irvine$3.2M · 2 projects
  7. University of Illinois at Urbana-Champaign$3.0M · 2 projects
  8. University of Wisconsin-Madison$3.0M · 3 projects

Funding institutes

  • NIGMS$91.4M · 196
  • NCI$6.9M · 11
  • NIA$5.2M · 6

Activity codes funded

  • R01212 records
  • RF11 record

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-203. Contact the program officer at the institute that fits your research before applying.

  • NIGMS · National Institute of General Medical Sciences
  • none

Related notices

  1. Jan 28, 2026 · NOT-OD-26-029

    NIH Removing AIDS Application Due Dates from NOFOs. See Notice NOT-OD-26-029.

  2. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  3. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  4. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Notices of Special Interest (NOSIs)

NIH has attached 3 NOSIs to PAR-25-203; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.

Award terms

Application types allowed
NewRenewal The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are not limited but must reflect the actual needs of the proposed project. Applications proposing projects that have early feasibility data but significant risk due to their early stage of development may request reduced budgets or a reduced duration in their applications. Applications proposing projects that are well supported by feasibility studies and are ready to develop…
Project period
The scope of the proposed project should determine the project period. The maximum project period is 5 years, although investigators supported by NIGMS who are not ESIs will generally receive no more than four years of support in a project period. The grant may be renewed only one time. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications…
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the number of meritorious applications received.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-22-127.
  • Companion NOFOs: PAR-25-202.

Other open NOFOs for R01

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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