NIH PAR · NCATS · R03

PAR-25-122: Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Oct 16, 2026Expires Nov 17, 2027

The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to elucidate a role for understudied proteins in rare disease. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s). A list of eligible proteins is provided and are members of druggable protein families that have a known association with a rare disease. This NOFO is intended to jumpstart research on understudied proteins that are associated with rare diseases and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins within the context of rare…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-122
Type
PAR
Activity code
R03
Primary institute
NCATS · National Center for Advancing Translational Sciences
Clinical trials
Not Allowed
Posted
Oct 28, 2024
Opens
Jan 16, 2025
Expires
Nov 17, 2027

PAR-25-122 due dates

4 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-122
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 16, 2025March 16, 2025 *Not ApplicableJuly 2025October 2025December 2025
June 16, 2025July 16, 2025 *Not ApplicableNovember 2025January 2026April 2026
October 16, 2025November 16, 2025 *Not ApplicableMarch 2026May 2026July 2026
February 16, 2026March 16, 2026 *Not ApplicableJuly 2026October 2026December 2026
June 16, 2026July 16, 2026 *Not ApplicableNovember 2026January 2027April 2027
October 16, 2026November 16, 2026 *Not ApplicableMarch 2027May 2027July 2027
February 16, 2027March 16, 2027 *Not ApplicableJuly 2027October 2027December 2027
June 16, 2027July 16, 2027 *Not ApplicableNovember 2027January 2028April 2028
October 16, 2027November 16, 2027 *Not ApplicableMarch 2028May 2028July 2028

Projects funded under PAR-25-122

NIH RePORTER lists 25 projects funded under PAR-25-122 in FY2022–FY2026, with $4.0M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

25

Distinct projects, FY2022–FY2026

New awards

25

Type 1 (new project) award records

NIH funding

$4.0M

Award dollars under PAR-25-122, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-122
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY20262525$4.0M

Institutions with the most funding

  1. Icahn School of Medicine at Mount Sinai$352K · 2 projects
  2. University of Chicago$328K · 2 projects
  3. UT Southwestern Medical Center$323K · 2 projects
  4. University of Alabama at Birmingham$290K · 2 projects
  5. Oklahoma Medical Research Foundation$171K · 1 project
  6. Yale University$168K · 1 project
  7. Univ of Massachusetts Med Sch Worcester$168K · 1 project
  8. National Jewish Health$164K · 1 project

Funding institutes

  • NCATS$1.6M · 10
  • NINDS$1.4M · 9
  • NIAID$672K · 4
  • NIDCR$312K · 2

Activity codes funded

Most recent new awards

What its predecessor RFA-TR-22-030 funded

PAR-25-122 reissues RFA-TR-22-030. Its funding history is the best guide to who wins under this program: 58 projects and $9.4M in FY2022–FY2026.

Projects funded

58

Distinct projects, FY2022–FY2026

New awards

58

Type 1 (new project) award records

NIH funding

$9.4M

Award dollars under RFA-TR-22-030, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under RFA-TR-22-030
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY20232424$3.9M
FY20242020$3.3M
FY20251414$2.2M
FY202600$0

Institutions with the most funding

  1. Children's Hosp of Philadelphia$722K · 4 projects
  2. Washington University$467K · 3 projects
  3. University of California, San Diego$374K · 2 projects
  4. Boston Children's Hospital$355K · 2 projects
  5. Weill Medical Coll of Cornell Univ$339K · 2 projects
  6. University of Iowa$329K · 2 projects
  7. Johns Hopkins University$328K · 2 projects
  8. University of Texas Hlth Sci Ctr Houston$312K · 2 projects

Funding institutes

  • NCATS$7.1M · 44
  • NINDS$1.3M · 8
  • NIMH$798K · 5
  • NIAMS$160K · 1

Activity codes funded

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

6 NIH institutes and offices take applications under PAR-25-122. Contact the program officer at the institute that fits your research before applying.

  • NCATS · National Center for Advancing Translational Sciences
  • NIAID · National Institute of Allergy and Infectious Diseases
  • NIDCD · National Institute on Deafness and Other Communication Disorders
  • NIDCR · National Institute of Dental and Craniofacial Research
  • NIMH · National Institute of Mental Health
  • NINDS · National Institute of Neurological Disorders and Stroke

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Award terms

Application types allowed
NewResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are limited to 100,000 in direct costs excluding subcontract F&A) for one year and need to reflect the actual needs of the proposed project.
Project period
The maximum project period for an application submitted under this NOFO is 1 year. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of RFA-TR-22-030.

Other open NOFOs for R03

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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