NIH PA · NIH · K99, R00
PA-24-194: NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of the NIH Pathway to Independence Award (K99/R00) program is to increase and maintain a strong cohort of new and talented, NIH-supported, independent investigators. This program is designed to facilitate a timely transition of outstanding postdoctoral researchers with a research and/or clinical doctorate degree from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition in order to help awardees to launch competitive, independent research careers.
- NOFO number
- PA-24-194
- Type
- PA
- Primary institute
- NIH
- Clinical trials
- Not Allowed
- Posted
- Apr 24, 2024
- Opens
- May 10, 2024
- Expires
- May 8, 2027
PA-24-194 due dates
No application due dates remain in the listed cycles. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Letter of Intent Due Date(s) |
|---|
| Not Applicable |
| June 12, 2024 |
| July 12, 2024 * |
| September 07, 2024 * |
| November 2024 |
| January 2025 |
| April 2025 |
| October 12, 2024 |
| November 12, 2024 * |
| January 07, 2025 * |
| March 2025 |
| May 2025 |
| July 2025 |
| February 12, 2025 |
| March 12, 2025 * |
| May 07, 2025 * |
| July 2025 |
| October 2025 |
| December 2025 |
| June 12, 2025 |
| July 12, 2025 * |
| September 07, 2025 * |
| November 2025 |
| January 2026 |
Projects funded under PA-24-194
NIH RePORTER lists 602 projects funded under PA-24-194 in FY2022–FY2026, with $105.1M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
602
Distinct projects, FY2022–FY2026
New awards
575
Type 1 (new project) award records
NIH funding
$105.1M
Award dollars under PA-24-194, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 194 | 192 | $26.8M |
| FY2026 | 578 | 383 | $78.3M |
Institutions with the most funding
- Stanford University$7.9M · 44 projects
- University of California, San Francisco$5.1M · 32 projects
- University of Pennsylvania$3.7M · 21 projects
- Columbia University Health Sciences$3.5M · 20 projects
- Massachusetts General Hospital$3.1M · 17 projects
- Icahn School of Medicine at Mount Sinai$2.6M · 12 projects
- Johns Hopkins University$2.6M · 16 projects
- University of California, San Diego$2.5M · 16 projects
Most recent new awards
- Defining how Bacterial-Sensing Caspases Regulate RNA Metabolism and Immunity (opens NIH RePORTER)
University of Pennsylvania · 1K99AI202747-01 · NIAID · Notice Sep 18, 2026
$147KK99
- Post translational modifications as a therapeutic target for Huntington's Disease (opens NIH RePORTER)
University of California-Irvine · 1K99NS144617-01A1 · NINDS · Notice Sep 17, 2026
$120KK99
- Cellular Mechanisms of Selective Interneuronal Vulnerability in Alzheimer’s Disease (opens NIH RePORTER)
Massachusetts Institute of Technology · 1K99AG095269-01A1 · NIA · Notice Sep 17, 2026
$135KK99
- Regulation of mitochondrial function by O-GlcNAcylation in progressive heart failure (opens NIH RePORTER)
Virginia Polytechnic Inst and St Univ · 1K99HL183750-01A1 · NHLBI · Notice Sep 17, 2026
$163KK99
- Investigating the relationship between totipotency and epigenetic reprogramming during the formation of induced pluripotent stem cells (opens NIH RePORTER)
University of California Santa Cruz · 1K99GM162991-01A1 · NIGMS · Notice Sep 17, 2026
$125KK99
- Leveraging Ambulatory Technology to Assess Cognitive-Affective Processes in Suicidal Ideation Among High-Risk Adolescents (opens NIH RePORTER)
Massachusetts General Hospital · 1K99MH142686-01A1 · NIMH · Notice Sep 17, 2026
$129KK99
What its predecessor PA-20-188 funded
PA-24-194 reissues PA-20-188. Its funding history is the best guide to who wins under this program: 1,878 projects and $672.5M in FY2022–FY2026.
Projects funded
1,878
Distinct projects, FY2022–FY2026
New awards
897
Type 1 (new project) award records
NIH funding
$672.5M
Award dollars under PA-20-188, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 480 | 282 | $59.8M |
| FY2023 | 722 | 293 | $110.1M |
| FY2024 | 933 | 251 | $163.7M |
| FY2025 | 898 | 71 | $185.7M |
| FY2026 | 656 | 0 | $153.2M |
Institutions with the most funding
- Stanford University$25.6M · 101 projects
- University of Michigan at Ann Arbor$17.3M · 45 projects
- Massachusetts General Hospital$16.6M · 55 projects
- University of California, San Francisco$16.1M · 55 projects
- Washington University$15.2M · 39 projects
- Yale University$14.7M · 43 projects
- Columbia University Health Sciences$14.4M · 47 projects
- University of Colorado Denver$14.2M · 33 projects
Most recent new awards
- Epigenetic modulations by sleep to mitigate neurodegeneration (opens NIH RePORTER)
Washington University · 1K99AG090693-01 · NIA · Notice Sep 15, 2025
$125KK99
- Apoptotic Dysregulation Across Cell Types in Aging and Neurodegeneration (opens NIH RePORTER)
Univ of Massachusetts Med Sch Worcester · 1K99AG086405-01A1 · NIA · Notice Sep 4, 2025
$132KK99
- Characterizing determinants of cellular senescence and epigenetic dysregulation on tobacco smoke exposure in lung (opens NIH RePORTER)
University of Rochester · 1K99HL171851-01A1 · NHLBI · Notice Aug 26, 2025
$114KK99
- Macrophage identity as a function of cell of origin (opens NIH RePORTER)
Boston Children's Hospital · 1K99AI187733-01 · NIAID · Notice Aug 21, 2025
$123KK99
- Identifying Ecological Drivers of Dysbiosis in the Female Reproductive Tract (opens NIH RePORTER)
University of California at Davis · 1K99AI187628-01 · NIAID · Notice Aug 21, 2025
$126KK99
- Systematic dissection of viral genetic interactions and mutations with COEXPRES-Seq (opens NIH RePORTER)
Princeton University · 1K99AI182471-01A1 · NIAID · Notice Aug 18, 2025
$101KK99
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
24 NIH institutes and offices take applications under PA-24-194. Contact the program officer at the institute that fits your research before applying.
- NIH
- NEI · National Eye Institute
- NHLBI · National Heart, Lung, and Blood Institute
- NHGRI · National Human Genome Research Institute
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NIAID · National Institute of Allergy and Infectious Diseases
- NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
- NIBIB · National Institute of Biomedical Imaging and Bioengineering
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCD · National Institute on Deafness and Other Communication Disorders
- NIDCR · National Institute of Dental and Craniofacial Research
- NIDDK · National Institute of Diabetes and Digestive and Kidney Diseases
- NIDA · National Institute on Drug Abuse
- NIEHS · National Institute of Environmental Health Sciences
- NIGMS · National Institute of General Medical Sciences
- NIMH · National Institute of Mental Health
- NINDS · National Institute of Neurological Disorders and Stroke
- NINR · National Institute of Nursing Research
- NIMHD · National Institute on Minority Health and Health Disparities
- NLM · National Library of Medicine
- NCCIH · National Center for Complementary and Integrative Health
- ORWH
- ODSS
Related notices
Jan 30, 2026 · NOT-OD-26-021
Notice of Temporary Extension of Eligibility for the NIH Pathway to Independence Award K99/R00).
Nov 24, 2025 · NOT-DE-26-013
Notice of Rescheduled NIDCR Pre-Application and Technical Assistance Webinars on Applying for Fellowship F) Awards and Career Development K) Awards.
Sep 25, 2025 · NOT-DE-26-012
Notice of NIDCR Pre-Application and Technical Assistance Webinars on Applying for Fellowship F) Awards and Career Development K) Awards.
Sep 9, 2025 · NOT-AR-25-015
Notice of Change to Salary Cap for NIH Pathway to Independence Award Parent K99/R00 Independent Clinical Trial Not Allowed).
Jun 13, 2025 · NOT-OD-25-121
Temporary Extension of Eligibility for the NIH Pathway to Independence Award K99/R00).
Mar 31, 2025
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.
Jan 15, 2025 · NOT-CA-25-021
Notice of the Discontinuation of NCI's Participation in PA-24-193, PA-24-194 & PA-24-195 NIH Pathway to Independence Award Parent K99/R00).
Apr 4, 2024 · NOT-OD-24-084
Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025.
Sep 25, 2024 · NOT-HD-24-037
Notice of a Virtual Question and Answer Informational Session" with NICHD Staff for the K99/R00 Pathway to Independence Award.
Jun 4, 2024 · NOT-MD-24-017
Guidance Regarding Reduction of Effort for NIMHD Individual Mentored K Awards.
May 30, 2024 · NOT-DA-24-032
Notice to Alert the Public of NIDA's Career Development Award Salary Limits.
May 7, 2024 · NOT-AI-24-038
Notice of Information: NIAID to Increase K99, K25, and K01 Salary and Research Support and R00 Years of Support.
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Notices of Special Interest (NOSIs)
NIH has attached 56 NOSIs to PA-24-194; 1 are active. A NOSI flags a topic an institute wants to fund through this NOFO.
- Notice to Alert the Public of NIDA's Career Development Award Salary LimitsNOT-DA-24-032 · NIDA · until Oct 16, 2026
Award terms
- Application types allowed
- NewResubmissionRevision The OER Glossary and the How to Apply - Application Guide provides details on these application types.
- Award budget
- Information
- Project period
- The total project period may not exceed 5 years. Other
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PA-20-188.
- Companion NOFOs: PA-24-193, PA-24-195.
Other open NOFOs for K99, R00
- PAR-27-076Lasker Clinical Research Scholar's Program (Si2/R00 Clinical Trial Optional)NIH · next due Nov 6, 2026
- PA-24-193NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)NIH
- PAR-25-333NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)NIDCR · next due Feb 12, 2027
- PAR-25-313NCI Pathway to Independence Award (K99/R00 Clinical Trial Required)NCI · next due Feb 17, 2027
- PAR-25-135NCI Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)NCI · next due Feb 17, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.