NIH PA · NIH · K99, R00
PA-24-193: NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of the NIH Pathway to Independence Award (K99/R00) program is to increase and maintain a strong cohort of new and talented, NIH-supported, independent investigators. This program is designed to facilitate a timely transition of outstanding postdoctoral researchers with a research and/or clinical doctorate degree from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition in order to help awardees to launch competitive, independent research careers.
- NOFO number
- PA-24-193
- Type
- PA
- Primary institute
- NIH
- Clinical trials
- Required
- Posted
- Apr 24, 2024
- Opens
- May 10, 2024
- Expires
- May 8, 2027
PA-24-193 due dates
No application due dates remain in the listed cycles. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Letter of Intent Due Date(s) |
|---|
| Not Applicable |
| June 12, 2024 |
| July 12, 2024 * |
| September 07, 2024 * |
| November 2024 |
| January 2025 |
| April 2025 |
| October 12, 2024 |
| November 12, 2024 * |
| January 07, 2025 * |
| March 2025 |
| May 2025 |
| July 2025 |
| February 12, 2025 |
| March 12, 2025 * |
| May 07, 2025 * |
| July 2025 |
| October 2025 |
| December 2025 |
| June 12, 2025 |
| July 12, 2025 * |
| September 07, 2025 * |
| November 2025 |
| January 2026 |
Projects funded under PA-24-193
NIH RePORTER lists 30 projects funded under PA-24-193 in FY2022–FY2026, with $4.8M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
30
Distinct projects, FY2022–FY2026
New awards
29
Type 1 (new project) award records
NIH funding
$4.8M
Award dollars under PA-24-193, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 8 | 8 | $924K |
| FY2026 | 30 | 21 | $3.9M |
Institutions with the most funding
- University of Illinois at Chicago$681K · 4 projects
- Stanford University$527K · 3 projects
- University of Florida$350K · 2 projects
- New York University School of Medicine$311K · 2 projects
- UT Southwestern Medical Center$271K · 2 projects
- University of Texas Hlth Sci Ctr Houston$264K · 1 project
- Tulane University of Louisiana$248K · 1 project
- University of Pennsylvania$231K · 1 project
Most recent new awards
- Leveraging Nurses to Improve Care for Postural Orthostatic Tachycardia Syndrome (opens NIH RePORTER)
New York University School of Medicine · 1K99NR022359-01 · NINR · Notice Sep 18, 2026
$134KK99
- Cortical mechanisms of cognitive-motor interactions in mild cognitive impairment (opens NIH RePORTER)
University of Florida · 1K99AG095278-01A1 · NIA · Notice Sep 15, 2026
$111KK99
- Defining Orbitofrontal Circuit Function in Health and Depression (opens NIH RePORTER)
University of California, San Francisco · 1K99MH146164-01 · NIMH · Notice Sep 14, 2026
$119KK99
- Designing and Measuring Personalized Care Management Interventions for Caregivers of Older Adults with Alzheimer's Disease and Related Dementias (opens NIH RePORTER)
Indiana University Indianapolis · 1K99AG104162-01 · NIA · Notice Sep 11, 2026
$98KK99
- Physical Activity Behavior Change Intervention in Persons Newly Diagnosed with Multiple Sclerosis - ActivNMS Trial (opens NIH RePORTER)
University of Illinois at Chicago · 1K99HD120630-01A1 · NICHD · Notice Sep 9, 2026
$139KK99
- A Hybrid Type 1 Effectiveness-Implementation Trial of a Digital Health Intervention for Youth in Out-of-Home Care (opens NIH RePORTER)
Florida State University · 1K99HD120617-01 · NICHD · Notice Sep 4, 2026
$125KK99
What its predecessor PA-20-187 funded
PA-24-193 reissues PA-20-187. Its funding history is the best guide to who wins under this program: 112 projects and $40.1M in FY2022–FY2026.
Projects funded
112
Distinct projects, FY2022–FY2026
New awards
53
Type 1 (new project) award records
NIH funding
$40.1M
Award dollars under PA-20-187, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 25 | 17 | $3.2M |
| FY2023 | 48 | 20 | $7.1M |
| FY2024 | 52 | 13 | $8.7M |
| FY2025 | 53 | 3 | $11.4M |
| FY2026 | 44 | 0 | $9.5M |
Institutions with the most funding
- Rutgers Biomedical and Health Sciences$3.0M · 6 projects
- University of Illinois at Chicago$2.8M · 7 projects
- Massachusetts General Hospital$1.9M · 5 projects
- University of Washington$1.4M · 5 projects
- University of Minnesota$1.3M · 4 projects
- Medical University of South Carolina$1.2M · 3 projects
- University of Chicago$1.1M · 2 projects
- Medical College of Wisconsin$962K · 2 projects
Most recent new awards
- Operant conditioning of the wrist extensor motor evoked potential to target corticospinal plasticity and upper limb motor recovery after cervical spinal cord injury (opens NIH RePORTER)
Medical University of South Carolina · 1K99HD117041-01 · NICHD · Notice Apr 14, 2025
$116KK99
- Mechanisms and Efficacy of Physical Activity to Reduce Cardiovascular Morbidity in Women with Breast Cancer (opens NIH RePORTER)
Virginia Commonwealth University · 1K99HL173554-01A1 · NHLBI · Notice Jan 10, 2025
$134KK99
- Targeting transdiagnostic self-regulatory factors and eating disorder pathology among adults with binge-spectrum eating disorders: A mHealth interoceptive exposure intervention (opens NIH RePORTER)
University of Minnesota · 1K99MH138634-01 · NIMH · Notice Dec 16, 2024
$99KK99
- SmartStart: A digitally-enhanced diabetes self-management intervention for low-income people newly diagnosed with type 2 diabetes (opens NIH RePORTER)
Arizona State University-Tempe Campus · 1K99MD019726-01 · NIMHD · Notice Sep 19, 2024
$111KK99
- Examining the Relationship Between Ongoing Alcohol Use, Suicidal Thoughts and Behaviors and Related Constructs, and Behavioral Economic Decision-Making (opens NIH RePORTER)
University of Kentucky · 1K99AA031309-01A1 · NIAAA · Notice Sep 9, 2024
$130KK99
- The Gut Microbial and Dietary Origins of Cancer Treatment-Related CognitiveImpairment (opens NIH RePORTER)
University of Illinois at Chicago · 1K99CA293168-01 · NCI · Notice Sep 6, 2024
$151KK99
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
20 NIH institutes and offices take applications under PA-24-193. Contact the program officer at the institute that fits your research before applying.
- NIH
- NHLBI · National Heart, Lung, and Blood Institute
- NHGRI · National Human Genome Research Institute
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
- NIBIB · National Institute of Biomedical Imaging and Bioengineering
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCD · National Institute on Deafness and Other Communication Disorders
- NIDDK · National Institute of Diabetes and Digestive and Kidney Diseases
- NIDA · National Institute on Drug Abuse
- NIEHS · National Institute of Environmental Health Sciences
- NIMH · National Institute of Mental Health
- NINDS · National Institute of Neurological Disorders and Stroke
- NINR · National Institute of Nursing Research
- NIMHD · National Institute on Minority Health and Health Disparities
- NLM · National Library of Medicine
- NCCIH · National Center for Complementary and Integrative Health
- ORWH
- ODSS
Related notices
Jan 30, 2026 · NOT-OD-26-021
Notice of Temporary Extension of Eligibility for the NIH Pathway to Independence Award K99/R00).
Sep 9, 2025 · NOT-AR-25-015
Notice of Change to Salary Cap for NIH Pathway to Independence Award Parent K99/R00 Independent Clinical Trial Not Allowed).
Jun 13, 2025 · NOT-OD-25-121
Temporary Extension of Eligibility for the NIH Pathway to Independence Award K99/R00).
Mar 31, 2025
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.
Jan 15, 2025 · NOT-CA-25-021
Notice of the Discontinuation of NCI's Participation in PA-24-193, PA-24-194 & PA-24-195 NIH Pathway to Independence Award Parent K99/R00).
Apr 4, 2024 · NOT-OD-24-084
Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025.
Sep 25, 2024 · NOT-HD-24-037
Notice of a Virtual Question and Answer Informational Session" with NICHD Staff for the K99/R00 Pathway to Independence Award.
Jun 4, 2024 · NOT-MD-24-017
Guidance Regarding Reduction of Effort for NIMHD Individual Mentored K Awards.
May 30, 2024 · NOT-DA-24-032
Notice to Alert the Public of NIDA's Career Development Award Salary Limits.
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Notices of Special Interest (NOSIs)
NIH has attached 34 NOSIs to PA-24-193; 1 are active. A NOSI flags a topic an institute wants to fund through this NOFO.
- Notice to Alert the Public of NIDA's Career Development Award Salary LimitsNOT-DA-24-032 · NIDA · until Oct 16, 2026
Award terms
- Application types allowed
- NewResubmissionRevision The OER Glossary and the How to Apply - Application Guide provides details on these application types.
- Award budget
- Information
- Project period
- The total project period may not exceed 5 years. Other
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PA-20-187.
- Companion NOFOs: PA-24-194, PA-24-195.
Other open NOFOs for K99, R00
- PAR-27-076Lasker Clinical Research Scholar's Program (Si2/R00 Clinical Trial Optional)NIH · next due Nov 6, 2026
- PA-24-194NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)NIH
- PAR-25-333NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)NIDCR · next due Feb 12, 2027
- PAR-25-313NCI Pathway to Independence Award (K99/R00 Clinical Trial Required)NCI · next due Feb 17, 2027
- PAR-25-135NCI Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)NCI · next due Feb 17, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.