NIH PAR · NCI · K99, R00

PAR-25-135: NCI Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Feb 17, 2027Expires Oct 15, 2027

The purpose of the NCI Pathway to Independence Award (K99/R00) program is to facilitate a timely transition of talented postdoctoral researchers with a research and/or clinical doctorate degree from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NCI research support during this transition in order to help awardees to launch competitive, independent research careers.

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-135
Type
PAR
Activity code
K99R00
Primary institute
NCI · National Cancer Institute
Clinical trials
Not Allowed
Posted
Nov 20, 2024
Opens
Jan 13, 2025
Expires
Oct 15, 2027

PAR-25-135 due dates

3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-135
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 13, 2025February 13, 2025Not ApplicableJuly 2025October 2025December 2025
June 17, 2025June 17, 2025Not ApplicableNovember 2025January 2026April 2026
October 15, 2025October 15, 2025Not ApplicableMarch 2026May 2026July 2026
February 13, 2026March 13, 2026Not ApplicableJuly 2026October 2026December 2026
June 15, 2026June 15, 2026Not ApplicableNovember 2026January 2027April 2027
October 14, 2026October 14, 2026Not ApplicableMarch 2027May 2027July 2027
February 17, 2027February 17, 2027Not ApplicableJuly 2027October 2027December 2027
June 15, 2027June 15, 2027Not ApplicableNovember 2027January 2028April 2028
October 14, 2027October 14, 2027Not ApplicableMarch 2028May 2028July 2028

Projects funded under PAR-25-135

NIH RePORTER lists 41 projects funded under PAR-25-135 in FY2022–FY2026, with $5.7M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

41

Distinct projects, FY2022–FY2026

New awards

41

Type 1 (new project) award records

NIH funding

$5.7M

Award dollars under PAR-25-135, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-135
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY20264141$5.7M

Institutions with the most funding

  1. Dana-Farber Cancer Inst$485K · 3 projects
  2. Stanford University$445K · 3 projects
  3. Sloan-Kettering Inst Can Research$437K · 3 projects
  4. Yale University$416K · 3 projects
  5. University of Tx MD Anderson Can Ctr$408K · 3 projects
  6. Massachusetts General Hospital$323K · 2 projects
  7. University of Pennsylvania$284K · 2 projects
  8. Weill Medical Coll of Cornell Univ$152K · 1 project

Funding institutes

  • NCI$5.7M · 41

Activity codes funded

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-135. Contact the program officer at the institute that fits your research before applying.

  • NCI · National Cancer Institute
  • none

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Award terms

Application types allowed
NewResubmission The OER Glossary and the How to Apply - Application Guide provides details on these application types.
Award budget
Information
Project period
The total project period may not exceed 5 years. Other
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

Other open NOFOs for K99, R00

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

NIH grant searchLook up awards by topic, PI, or institution.Find funded PIsInvestigators with recent NIH awards in your research area.Institute fit by topicWhich NIH institutes and institutions lead a research area.Funding trendsYear-by-year NIH award totals for any keyword.