NIH PAR · NIDCR · K99, R00
PAR-25-333: NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of the NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00) program is to develop and maintain a strong cohort of independently funded dentist scientists dedicated to improving dental, oral and craniofacial health. This program is designed to facilitate a timely transition of outstanding dual degree dentist scientists from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions by providing support for two years of mentored training and three to five years of independent research. An option for five years of independent (R00) support is available to accommodate clinical training in a dental specialty program…
- NOFO number
- PAR-25-333
- Type
- PAR
- Primary institute
- NIDCR · National Institute of Dental and Craniofacial Research
- Clinical trials
- Not Allowed
- Posted
- Jun 17, 2025
- Opens
- Jun 15, 2025
- Expires
- May 8, 2028
PAR-25-333 due dates
4 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| July 15, 2025 | July 15, 2025 | September 07, 2025 * | November 2025 | January 2026 | April 2026 |
| October 12, 2025 | November 12, 2025 * | January 07, 2026 * | March 2026 | May 2026 | July 2026 |
| February 12, 2026 | March 12, 2026 * | May 07, 2026 * | July 2026 | October 2026 | December 2026 |
| June 12, 2026 | July 12, 2026 * | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 12, 2026 | November 12, 2026 * | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 12, 2027 | March 12, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
| June 12, 2027 | July 12, 2027 * | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 12, 2027 | November 12, 2027 * | Not Applicable | March 2028 | May 2028 | July 2028 |
| February 12, 2028 | March 12, 2028 * | Not Applicable | July 2028 | October 2028 | December 2028 |
Projects funded under PAR-25-333
NIH RePORTER lists 3 projects funded under PAR-25-333 in FY2022–FY2026, with $435K in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
3
Distinct projects, FY2022–FY2026
New awards
3
Type 1 (new project) award records
NIH funding
$435K
Award dollars under PAR-25-333, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 3 | 3 | $435K |
Institutions with the most funding
- State University of New York at Buffalo$162K · 1 project
- Washington University$162K · 1 project
- Cleveland Clinic Lerner Com-Cwru$112K · 1 project
Funding institutes
- NIDCR$435K · 3
Activity codes funded
- K993 records
Most recent new awards
- Age-Related Immunometabolic Dysregulation in Periodontitis Resolution (opens NIH RePORTER)
State University of New York at Buffalo · 1K99DE036617-01 · NIDCR · Notice Sep 17, 2026
$162KK99
- Determining migration and functional profiles of memory T cells subsets in Periodontitis (opens NIH RePORTER)
Cleveland Clinic Lerner Com-Cwru · 1K99DE036317-01 · NIDCR · Notice Aug 24, 2026
$112KK99
- Mechanisms of accelerated regeneration in neural crest-derived bone (opens NIH RePORTER)
Washington University · 1K99DE034706-01A1 · NIDCR · Notice Jul 20, 2026
$162KK99
What its predecessor PAR-22-041 funded
PAR-25-333 reissues PAR-22-041. Its funding history is the best guide to who wins under this program: 14 projects and $4.5M in FY2022–FY2026.
Projects funded
14
Distinct projects, FY2022–FY2026
New awards
7
Type 1 (new project) award records
NIH funding
$4.5M
Award dollars under PAR-22-041, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 2 | 2 | $263K |
| FY2024 | 6 | 4 | $897K |
| FY2025 | 8 | 1 | $1.5M |
| FY2026 | 8 | 0 | $1.9M |
Institutions with the most funding
- State University of New York at Buffalo$991K · 2 projects
- Ada Forsyth Institute, Inc.$903K · 3 projects
- University of Pennsylvania$503K · 2 projects
- University of Minnesota$494K · 1 project
- University of Oregon$444K · 1 project
- University of Michigan at Ann Arbor$270K · 1 project
- University of Illinois at Chicago$249K · 1 project
- Boston University Medical Campus$249K · 1 project
Most recent new awards
- Bioinspired Synthetic High-Density Lipoprotein (sHDL) nanotherapeutics with immunomodulatory and regenerative potential in endodontics (opens NIH RePORTER)
University of Michigan at Ann Arbor · 1K99DE035132-01 · NIDCR · Notice Jul 29, 2025
$135KK99
- Roles of neutrophil-sensory neuron interactions in dental pulp inflammation and pain (opens NIH RePORTER)
Harvard Medical School · 1K99DE033421-01 · NIDCR · Notice Feb 14, 2024
$121KK99
- Bone-like organoids to understand factors controlling local bone immune response and regeneration (opens NIH RePORTER)
University of Oregon · 1K99DE033689-01 · NIDCR · Notice Feb 9, 2024
$222KK99
- From Symbiosis to Dysbiosis and Back: The Impact of Pro-Inflammation and Pro-Resolution (opens NIH RePORTER)
Ada Forsyth Institute, Inc. · 1K99DE032048-01A1 · NIDCR · Notice Feb 6, 2024
$165KK99
- Probing the role of Selenomonas sputigena in supragingival biofilm spatial structuring and virulence (opens NIH RePORTER)
University of Pennsylvania · 1K99DE033428-01 · NIDCR · Notice Jan 23, 2024
$127KK99
- The Role of Tufts Cells in Salivary Gland Immunity (opens NIH RePORTER)
University of Missouri-Columbia · 1K99DE032363-01A1 · NIDCR · Notice Sep 18, 2023
$101KK99
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under PAR-25-333. Contact the program officer at the institute that fits your research before applying.
- NIDCR · National Institute of Dental and Craniofacial Research
- none
Related notices
Jan 30, 2026 · NOT-OD-26-021
Notice of Temporary Extension of Eligibility for the NIH Pathway to Independence Award K99/R00).
Nov 24, 2025 · NOT-DE-26-013
Notice of Rescheduled NIDCR Pre-Application and Technical Assistance Webinars on Applying for Fellowship F) Awards and Career Development K) Awards.
Sep 25, 2025 · NOT-DE-26-012
Notice of NIDCR Pre-Application and Technical Assistance Webinars on Applying for Fellowship F) Awards and Career Development K) Awards. See Notice NOT-DE-26-012.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Notices of Special Interest (NOSIs)
NIH has attached 1 NOSI to PAR-25-333; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.
Award terms
- Application types allowed
- NewResubmission The OER Glossary and the How to Apply - Application Guide provides details on these application types.
- Award budget
- Information
- Project period
- The total project period may not exceed 7 years.Mentored Phase K99): Support for 2 years mentored postdoctoral research training and career development.Independent Phase R00): Independent research support for either 3 or 5 years, which is contingent on satisfactory progress during the K99 phase and an approved, independent, tenure-track or equivalent) faculty position.R00 support beyond…
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-22-041.
Other open NOFOs for K99, R00
- PAR-27-076Lasker Clinical Research Scholar's Program (Si2/R00 Clinical Trial Optional)NIH · next due Nov 6, 2026
- PA-24-194NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)NIH
- PAR-25-313NCI Pathway to Independence Award (K99/R00 Clinical Trial Required)NCI · next due Feb 17, 2027
- PAR-25-135NCI Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)NCI · next due Feb 17, 2027
- PA-24-193NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)NIH
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.