NIH K99/R00 Grants — Pathway to Independence Award

Recent K99/R00 awards from NIH RePORTER

Examples of funded K99/R00 projects across the last two fiscal years. The matching-award count comes from the full result set; funding totals, averages, rankings, and examples use the first 500 records returned by NIH RePORTER. Figures reflect a snapshot last refreshed on September 5, 2026.

Example K99/R00 projects from the sample

• Using miRNA to identify new therapeutic pathways for dilated cardiomyopathy

  5R00HL165099-04
  Francesca Briganti · UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA · $247,482 · awarded Aug 28, 2026 · NIH

  SUMMARY Dilated cardiomyopathy (DCM) associated heart failure is a leading cause of death and new therapeutic strategies are needed. Pathogenic variants in over 50 genes contribute to DCM, but the molecular mechanisms of disease are poorly understood. Much remains to be done to understand disease mechanisms and translate the basic science into therapeutic…

• Dissecting Oxygen Sensing and PTEN Loss in FDG/Fluciclovine Uptake as Markers of PSMA Radioligand Therapy Resistance

  1K99CA315599-01
  Martin Bakht · DANA-FARBER CANCER INST, MA · $170,639 · awarded Aug 24, 2026 · NIH

  PROJECT SUMMARY: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) has transformed staging and therapeutic selection in advanced prostate cancer, but responses to PSMA-directed radioligand therapy (RLT) remain heterogeneous. A substantial fraction of patients lack sufficient PSMA expression, and many PSMA-positive tumors develop…

• Deciphering and manipulating the dynamic signaling and transcriptional programs of appendage regeneration

  1K99HD121969-01
  Sushant Bangru · MORGRIDGE INSTITUTE FOR RESEARCH, INC., WI · $131,832 · awarded Aug 21, 2026 · NIH

  ABSTRACT The ability to regenerate complex tissues with correct size, and shape remains a central question in regenerative biology. While mammals can regenerate bony structures in limited contexts such as digit tips, zebrafish restore dermal appendages like scales and fins with striking precision—offering externally accessible tissues that regenerate within…

• Identifying Druggable Genetic Factors Underlying Radiation-induced Heart Disease

  5K99HL177331-02
  Xu Cao · STANFORD UNIVERSITY, CA · $160,818 · awarded Aug 21, 2026 · NIH

  PROJECT SUMMARY Radiotherapy (RT) is a widely utilized treatment in cancer patients. However, RT for thoracic malignancies can inadvertently harm the heart, resulting in radiation-induced heart diseases (RIHD). Despite the prevalence of RIHD, the underlying mechanisms are not fully comprehended, and effective therapeutic strategies are lacking. Existing…

• Genomics of OCD in Latin American Communities

  5R00MH128540-04
  Carolina Cappi · RUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ · $249,000 · awarded Aug 21, 2026 · NIH

  PROJECT SUMMARY In this study, I seek to understand how common and rare genetic variation influences the risk of developing obsessive-compulsive disorder (OCD). OCD is a disabling psychiatric condition with unclear pathophysiology, which has hindered the development of effective treatments and interventions. Although there is strong evidence of genetic…

• Developing a multicomponent lifestyle intervention to address obesity and cardiometabolic risk in Samoan children

  4R00HL166781-03
  Courtney Choy · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, UT · $249,000 · awarded Aug 21, 2026 · NIH

  PROJECT SUMMARY The goal of the proposed K99/R00 award is to support Dr. Courtney Choy’s development as an independent, community-engaged implementation scientist and epidemiologist focused on the prevention and treatment of noncommunicable, cardiometabolic diseases (CMD). Obesity and cardiometabolic risk are emerging earlier in life than ever before and…

• Exploring the role of Hedgehog pathway-Primary cilia axis in human lung alveologenesis and disease

  5K99HL177341-02
  RANDA BELGACEMI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER, CA · $156,168 · awarded Aug 18, 2026 · NIH

  Project Summary/ Abstract Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease of prematurity, characterized by defective gas exchange area, due to reduced alveolar surface. The alveolar epithelium is composed of squamous alveolar epithelial type 1 cells (AT1), which cover more than 90% of the alveolar surface, and cuboidal alveolar…

• Molecular mechanisms of transcriptional regulation of phototransduction genes in mammalian rod photoreceptors

  5R00EY030918-04
  Elsa Corso-Diaz · STANFORD UNIVERSITY, CA · $249,000 · awarded Aug 18, 2026 · NIH

  Transcriptional elongation and mRNA processing occur simultaneously and are highly coupled to increase the efficiency and accuracy of mRNA maturation. Splicing is a step of mRNA processing where intronic regions are removed by spliceosome complexes that bind pre-mRNA. Most human genes with multiple exons are alternatively spliced generating numerous…

• Towards elucidating PTSD pathogenesis with ultra-portable and low-cost neuroimaging

  4R00MH132880-03
  STEPHANIE BALTERS · STANFORD UNIVERSITY, CA · $249,000 · awarded Aug 17, 2026 · NIH

  PROJECT SUMMARY The long-term career goal of the K99/R00 applicant, Dr. Stephanie Balters, is to continue her career transition from engineering and functional Near-Infrared Spectroscopy (fNIRS) neuroimaging into the clinical neuroscience of Posttraumatic Stress Disorder (PTSD). Specifically, her aim is to develop fNIRS neuroimaging methods that will…

• Structural consequences of PKC-dependent phosphorylation of Kv7.2

  5R00GM146028-05
  Crystal Archer · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE, AR · $249,000 · awarded Aug 14, 2026 · NIH

  Project Summary M channels are critical for regulating the excitability of neurons. Dysfunction of M channel activity can cause epilepsy. While M channels have been intensely studied, the interplay of several G-protein-regulated signaling cofactors on these channels is still poorly understood. M channels are hetero-tetrameric pore structures formed by the…

• Social Mechanisms Underlying Sex Differences in Alzheimer’s Disease.

  5R00AG078440-04
  Justina Avila-Rieger · COLUMBIA UNIVERSITY HEALTH SCIENCES, NY · $249,000 · awarded Aug 14, 2026 · NIH

  Alzheimer’s disease (AD) is a major public health burden that disproportionately affects women. Women in the U.S. have experienced societal barriers that prevent them from accessing health-enhancing opportunities and resources that may have a negative impact on their AD risk. For Black women, the societal barriers associated with being a woman are further…

• Elucidating the role of Wnt/beta-catenin in mitochondrial metabolism and cell behavior

  1K99GM163031-01A1
  Luis Cedeno-Rosario · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, UT · $125,000 · awarded Aug 14, 2026 · NIH

  PROJECT SUMMARY/ABSTRACT Metabolism is one of the most tightly regulated cellular processes and is important for the maintenance of homeostasis; its deregulation is a hallmark for many diseases, including diabetes, cancer, and neurodegenerative diseases. The mitochondrial pyruvate carrier (MPC - comprised of the MPC1 and MPC2 proteins) is a transmembrane…

Compare nearby NIH grant mechanisms

Searchers often land on K99/R00 while deciding between adjacent NIH activity codes. Compare scope, NIH staff involvement, budget scale, and applicant stage before choosing a funding opportunity.