NIH K99/R00 Grants — Pathway to Independence Award

Recent K99/R00 awards from NIH RePORTER

Examples of funded K99/R00 projects across the last two fiscal years. The matching-award count comes from the full result set; funding totals, averages, rankings, and examples use the first 500 records returned by NIH RePORTER. Figures reflect a snapshot last refreshed on June 9, 2026.

Example K99/R00 projects from the sample

• Epigenetic and genetic regulation of arsenic methylation and arsenic-relatedcardiovascular disease risk

  4R00ES035109-03
  Anne Bozack · NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY · $248,999 · awarded Jun 5, 2026 · NIH

  SUMMARY In the United States, Native American communities face the greatest burden of chronic diseases among all ethnic groups and high rates of cardiovascular disease (CVD) incidence and mortality. Elevated disease risk may be in part attributed to arsenic in drinking water, which is a key environmental risk factor among rural households that rely on…

• Impact of DNA double-strand breaks on 3D genome organization and genome stability in Alzheimer's disease

  5R00AG073466-05
  Vishnu Dileep · BAYLOR COLLEGE OF MEDICINE, TX · $249,000 · awarded Jun 5, 2026 · NIH

  PROJECT SUMMARY/ABSTRACT The accumulation of DNA Double-Strand Breaks (DSBs) in neurons is an early hallmark of Alzheimer’s disease (AD). Increased DSBs are also associated with aging, which is the largest risk factor for AD. AD is also a complex disease involving all major brain glial cell types. Thus, there is a critical need to understand the molecular…

• Lipid peroxidation- and pyroptosis-induced tissue factor activation in pathogen-induced blood coagulation

  4R00HL166778-03
  Shabbir Ansari · UNIVERSITY OF TEXAS HLTH CTR AT TYLER, TX · $249,000 · awarded Jun 3, 2026 · NIH

  Tissue factor (TF), the primary initiator of the blood coagulation cascade, is carefully regulated to prevent aberrant coagulation activation. However, pathological conditions including bacterial and viral infection induce intravascular TF expression and lead to thrombosis. As TF-induced thrombosis is a major cause of acute myocardial infarction, ischemic…

• Elucidating Drug Interactomes for Cardiac Protection by SGLT2 Inhibitors

  5K99HL179400-02
  Arianne Caudal · STANFORD UNIVERSITY, CA · $131,085 · awarded Jun 3, 2026 · NIH

  PROJECT SUMMARY First designed to treat diabetes, sodium-glucose cotransporter-2 inhibitors (SGLT2i) were used to prevent glucose reabsorption in the kidney. Recent clinical trials of SGLT2i further demonstrated an unexpected and substantial reduction in heart failure hospitalizations in patients with and without diabetes. Since SGLT2 is lowly expressed in…

• The Impact of Social-Contextual Stressors on Psychopharmacological Mechanisms of Smoking Cessation and Relapse among Socioeconomically Disadvantaged Young Adults who Smoke Cigarettes

  4R00DA060983-02
  Mariel Bello · MEDICAL UNIVERSITY OF SOUTH CAROLINA, SC · $249,000 · awarded Jun 1, 2026 · NIH

  PROJECT SUMMARY Socioeconomically disadvantaged young adults (SDYA) are at a disproportionately greater risk of tobacco- related illness and disease compared to non-disadvantaged young adults in the U.S. Given that quitting smoking before age 30 reduces almost all of the mortality associated with ever smoking, understanding predictors of smoking cessation…

• Fast and Robust Distortion-Free Diffusion Weighted MRI for the Prostate

  1K99EB039095-01
  Jingjia Chen · NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY · $114,562 · awarded May 27, 2026 · NIH

  Project Summary Prostate cancer affects 1 out 8 men and is the second deadly cancer in the United States. Accurate detection of clinically significant disease is essential for guiding treatment decisions. Diffusion-weighted Imaging(DWI) is a key component of multiparametric MRI for prostate cancer detection and risk stratification. However, current clinical…

• Alzheimer's Disease and Related Dementia Neuropathologies and Exposures to Traffic Pollution Mixtures

  5R00AG086530-04
  Magali Blanco · UNIVERSITY OF WASHINGTON, WA · $248,834 · awarded May 26, 2026 · NIH

  PROJECT SUMMARY Alzheimer’s Disease (AD) and Related Dementias (ADRD) are a growing concern in our aging population. The identification of modifiable risk factors is critical. Growing evidence links ADRD to traffic-related air pollution (TRAP), a complex mixture of gasses and particles that includes ultrafine particles (UFP, ≤ 100 nm diameter), black carbon…

• Mechanisms that Enhance and Suppress HIV-1 Resistance in Gene Edited Primary Human Cells

  5R00HL172253-04
  Amanda Dudek · UNIVERSITY OF IOWA, IA · $249,000 · awarded May 25, 2026 · NIH

  While there have been great advances in HIV therapies over the past decades, the only true cure so far has been through hematopoietic stem cell transplant (HSCT) of cells naturally lacking the HIV co-receptor CCR5. Due to the toxicity of conditioning regimens prior to HSCT and significant morbidity due to graft-verses-host disease (GVHD), allogeneic HSCT is…

• Unraveling the Mechanisms of Opioid-Induced Airway Constriction: A Path towards Novel Therapeutics for Opioid Overdose

  5R00HL168211-04
  Nicholas Burgraff · UNIVERSITY OF WISCONSIN-MADISON, WI · $249,000 · awarded May 21, 2026 · NIH

  PROJECT SUMMARY This career development award will allow Dr. Nicholas Burgraff to establish an independent research career dedicated to understanding the neurophysiological control of airway function and its intricate interactions within neural networks that regulate respiration, with a pivotal focus on how various pharmaceuticals, notably opioids, can…

• Synthetic Reconstruction of Human Chaperone Networks in Yeast Models of Neurodegeneration

  4R00AG075242-03
  Edward Barbieri · TEMPLE UNIV OF THE COMMONWEALTH, PA · $249,000 · awarded May 19, 2026 · NIH

  Project Summary In aging neurons, the accumulation of key misfolded proteins into aggregates is a hallmark of many neurodegenerative diseases. For example, pathological forms of TDP43 become mislocalized to the cytoplasm and accumulate in aggregates in frontotemporal dementia (FTD) and other Alzheimer Disease-related Dementias (ADRD). Highly intricate…

• Study the impact of Bacterial Vaginosis toxins on mouse and human sperm function

  1K99HD122257-01
  Shweta Bhagwat · WASHINGTON UNIVERSITY, MO · $125,142 · awarded May 19, 2026 · NIH

  PROJECT SUMMARY/ABSTRACT Bacterial vaginosis (BV) is a common, recurrent vaginal dysbiosis affecting nearly 30% of reproductive-aged women in the U.S. It involves a loss of protective Lactobacillus and an overgrowth of anaerobes such as Gardnerella and Prevotella, leading to elevated levels of BV-associated toxins with major implications for gynecological…

• Menopause, hormone therapy and Alzheimer's disease clinicopathology: An in vivo perspective

  4R00AG083063-03
  Gillian Theresa Coughlan · MASSACHUSETTS GENERAL HOSPITAL, MA · $249,000 · awarded May 19, 2026 · NIH

  PROJECT SUMMARY / ABSTRACT In the United States, approximately 6.2 million people live with a clinical diagnosis of Alzheimer disease (AD). Postmenopausal women account for up to 70% of them. The overall goal of this proposed research is to elucidate the progressive pathophysiological mechanisms by which menopausal hormone therapy (HT) influences the risk…

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Searchers often land on K99/R00 while deciding between adjacent NIH activity codes. Compare scope, NIH staff involvement, budget scale, and applicant stage before choosing a funding opportunity.