NIH K08 Grants — Mentored Clinical Scientist Career Development Award
Reviewed by Dr. Meng ZhaoLast reviewed June 9, 2026Data refreshed September 5, 2026Editorial standards
Mentored research training for clinician-scientists doing lab/translational research
Funding
Salary support + ~$30K research/year
Duration
3–5 years
Eligibility
Clinicians (MD, DO, DDS, etc.) within ~5 years of training completion
Activity code
K08
What is the NIH K08 grant?
The K08 is the NIH career development award for clinician-scientists (MDs, DOs, DDSs, etc.) doing laboratory or translational research. It provides 75% protected research time plus a research allowance for 3–5 years and is the standard training-to-independence path for physician-scientists planning to run a research lab.
Recent K08 awards from NIH RePORTER
Examples of funded K08 projects across the last two fiscal years. The matching-award count comes from the full result set; funding totals, averages, rankings, and examples use the first 500 records returned by NIH RePORTER. Figures reflect a snapshot last refreshed on September 5, 2026.
Example K08 projects from the sample
Role of stromal inflammatory signaling in the aging of lung resident lymphocytes
5K08HL169723-04Nancy Allen · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA · $169,020 · awarded Aug 24, 2026 · NIHPROJECT SUMMARY Immune system dysfunction has been implicated in the pathogenesis of several age-related lung diseases. Interestingly, multiple recent studies have identified the tissue microenvironment as playing a critical role in the pathogenesis of some of these age-related immune system changes. The lung mesenchyme provides a supportive niche for the…
Digital Twins for Accelerating Clinical Trial Innovation in Alcohol-Associated Hepatitis
1K08AA033404-01Joseph Ahn · MAYO CLINIC ROCHESTER, MN · $202,176 · awarded Aug 21, 2026 · NIHPROJECT SUMMARY Alcohol-associated hepatitis (AH) is a severe form of liver disease and a leading cause of liver-related mortality in the U.S., yet the therapeutic landscape remains critically underserved. Clinical trials for new AH therapies are profoundly impaired by low patient enrollment and poor retention, creating a major bottleneck that has stalled…
Immunosuppressive Neutrophils Modulate Alloimmune Responses After Lung Transplantation
5K08HL181281-02Amit Bery · WASHINGTON UNIVERSITY, MO · $166,364 · awarded Aug 21, 2026 · NIHProject Summary/Abstract This proposal outlines a 5-year research and career development plan to support Dr. Amit Bery’s transition to independence as a physician-scientist studying how innate immune cells affect adaptive immunity after lung transplantation. The proposed research project, which focuses on how interleukin-1β (IL-1β) promotes the…
Partitioned polygenic risk scoring and machine learning-derived imaging phenotypes for discovery of novel mechanisms of cardiometabolic disease in people of South Asian ancestry
1K08HL183778-01A1Romit Bhattacharya · MASSACHUSETTS GENERAL HOSPITAL, MA · $169,348 · awarded Aug 19, 2026 · NIHProject Summary / Abstract: Cardiovascular disease (CVD) is increasingly understood to be driven by metabolic dysfunction, as exemplified by the global epidemic of obesity and type 2 diabetes (T2D) and the risk conferred for myocardial infarction and heart failure. Individuals of South Asian ancestry face disproportionately high risks of myocardial…
Determining Protective Features of Human Memory T-cells to Inform Mycobacterium tuberculosis Vaccine Development
5K08AI163407-05Stephen Carpenter · CASE WESTERN RESERVE UNIVERSITY, OH · $193,320 · awarded Aug 19, 2026 · NIHProject Summary / Abstract Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (Mtb), is a disease that kills 1.4 million people every year. There is no reliable vaccine to prevent TB, yet many latently-infected individuals are protected from progressing to active TB despite heavy Mtb exposure living in an endemic setting. CD4+ T cells…
Characterizing the immune infiltrate in muscle-invasive urothelial carcinoma
5K08CA277016-04Katharine Collier · OHIO STATE UNIVERSITY, OH · $273,561 · awarded Aug 19, 2026 · NIHProject Summary Urothelial carcinoma is a common, aggressive, morbid, and understudied disease. Many patients are not cured with the current standard of care for localized muscle-invasive urothelial carcinoma, which is neoadjuvant combination cisplatin-based chemotherapy followed by radical cystectomy. But overall survival is significantly longer in…
Comparison of the Dysregulated and Regulated Host Responses to Infection
5K08AI193352-02Grace Fisler · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, NY · $162,000 · awarded Aug 18, 2026 · NIHProject Summary/Abstract: Comparison of the regulated and dysregulated host response to infection Brief Background: Sepsis is life-threatening organ dysfunction caused by an extensively studied but poorly understood dysregulated host response to infection. Specific therapy has focused on modifying the sepsis- associated immune response; the failures of…
Novel mechanisms of acute myeloid leukemia resistance to cell therapy
1K08CA304485-01A1ANAND BHAGWAT · CHILDREN'S HOSP OF PHILADELPHIA, PA · $263,656 · awarded Aug 17, 2026 · NIHAcute myeloid leukemia (AML) is a rapidly progressive cancer that occurs in children and adults and has no effective therapies for refractory disease. Chimeric antigen receptor T cell (CART) therapy has achieved impressive rates of response for some leukemias, but CART for AML has not been successful. We lack understanding of the ways AML evades killing by…
Muscle health and impaired glucose tolerance in adolescent and young adult hematopoietic cell transplantation survivors
1K08CA304491-01A1RUSHA BHANDARI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE, CA · $280,931 · awarded Aug 17, 2026 · NIHPROJECT SUMMARY Adolescents and young adults (AYAs, 15–39 years old) with cancer undergoing allogeneic hematopoietic cell transplantation (HCT) are a growing population who have experienced inferior improvements in outcomes compared to younger non-AYAs. AYAs undergoing HCT are at high risk of developing treatment-related complications, attributed to the…
Role of the Choroid Plexus in Neutrophil Recruitment After Traumatic Brain Injury
1K08NS148716-01Prajwal Ciryam · UNIVERSITY OF MARYLAND BALTIMORE, MD · $229,625 · awarded Aug 14, 2026 · NIHThis is a proposal for a five-year research career development program focused on the role of the choroid plexus in neutrophil entry into the brain after traumatic brain injury (TBI). The principal investigator, Dr. Prajwal Ciryam, M.D., Ph.D., is an Assistant Professor and attending neurointensivist in the Department of Neurology and Program in Trauma at…
Clinical and biologic health trajectories after early life adversity
5K08MH129657-05Barbara Chaiyachati · CHILDREN'S HOSP OF PHILADELPHIA, PA · $178,620 · awarded Aug 13, 2026 · NIHProject Summary/Abstract This career development award details a 5-year training plan to facilitate the transition of Dr. Barbara H. Chaiyachati to an independent career as a physician-scientist studying predictors of mental and physical health of children after trauma with an objective to identify actionable targets of intervention. Experiences of child…
The Interaction of Estradiol and Platelet Biology: A Mechanistic Exploration of Sex Dimorphisms in Coagulation
5K08HL179469-02Julia Coleman · OHIO STATE UNIVERSITY, OH · $163,296 · awarded Aug 10, 2026 · NIHPROJECT SUMMARY/ABSTRACT Dr. Julia Coleman is establishing herself as an early-career, translational surgeon-scientist with expertise in trauma-induced coagulopathy (TIC), sex dimorphisms in platelet function, and their mechanistic underpinnings to improve the care of injured patients. This K08 award will provide her with the support necessary to accomplish…
Funding institutes in the sample
| Institute | Awards | Funding |
|---|---|---|
| NIH | 494 | $92.2M |
| AHRQ | 6 | $892K |
Most frequent institutions in the sample
- MASSACHUSETTS GENERAL HOSPITAL — 31 awards
- WASHINGTON UNIVERSITY — 30 awards
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — 29 awards
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — 25 awards
- YALE UNIVERSITY — 19 awards
- STANFORD UNIVERSITY — 18 awards
- JOHNS HOPKINS UNIVERSITY — 17 awards
- UNIVERSITY OF COLORADO DENVER — 15 awards
Source: NIH RePORTER. Verify any award in the official record by searching its project number. See our data methodology for how this sample is built and its limitations.
Decision guide
Choose K08 when
Choose K08 when you are a clinician with a PhD or equivalent research training planning a lab-based career.
Choose another mechanism when
For patient-oriented or clinical-trials research, choose K23. For combined approaches, check institute FOAs — some allow either.
Who applies for K08
Clinicians within ~5 years of completion of subspecialty training, who want a primary research focus on basic or translational lab science. K08 is the lab-research counterpart to the patient-oriented K23.
Compare nearby NIH grant mechanisms
Searchers often land on K08 while deciding between adjacent NIH activity codes. Compare scope, NIH staff involvement, budget scale, and applicant stage before choosing a funding opportunity.
Mentored training for clinicians doing patient-oriented research
Postdoc → faculty transition (mentored K99 then independent R00)
Career development for new investigators needing mentored training
Protected time for established clinician-scientists to mentor
For broad grant lookup, use the NIH grant search to find funded examples by activity code, PI, institution, and award year.
Search tips for K08
- K08 awards are concentrated at academic medical centers — useful for tracking clinician-scientist talent pipelines.
Search NIH grants by activity code
Find K08-funded PIs
K08 funding trends
K08 frequently asked questions
What is the difference between K08 and K23?
K08 supports clinicians doing primarily lab-based or translational research. K23 supports clinicians doing patient-oriented research (clinical trials, observational studies, behavioral interventions). Both are mentored 3–5 year career development awards.
How much salary support does the K08 provide?
K08 salary support varies by institute and your institutional salary cap, but covers up to 75% effort. Most institutes cap K08 salary support around $100K–$130K/year.
Can I apply for an R01 while still on K08?
Yes — applying for R01 in the last 1–2 years of K08 is standard practice and expected. The K08 is designed to bridge to R01 independence.
Related NIH grant types
Mentored Patient-Oriented Research Career Development Award
Mentored training for clinicians doing patient-oriented research
Pathway to Independence Award
Postdoc → faculty transition (mentored K99 then independent R00)
Mentored Research Scientist Career Development Award
Career development for new investigators needing mentored training
Mid-Career Investigator Award in Patient-Oriented Research
Protected time for established clinician-scientists to mentor