KK Series — Career Development

NIH K08 Grants — Mentored Clinical Scientist Career Development Award

Reviewed by Dr. Meng ZhaoLast reviewed June 9, 2026Data refreshed September 5, 2026Editorial standards

Mentored research training for clinician-scientists doing lab/translational research

Funding

Salary support + ~$30K research/year

Duration

3–5 years

Eligibility

Clinicians (MD, DO, DDS, etc.) within ~5 years of training completion

Activity code

K08

What is the NIH K08 grant?

The K08 is the NIH career development award for clinician-scientists (MDs, DOs, DDSs, etc.) doing laboratory or translational research. It provides 75% protected research time plus a research allowance for 3–5 years and is the standard training-to-independence path for physician-scientists planning to run a research lab.

Recent K08 awards from NIH RePORTER

Examples of funded K08 projects across the last two fiscal years. The matching-award count comes from the full result set; funding totals, averages, rankings, and examples use the first 500 records returned by NIH RePORTER. Figures reflect a snapshot last refreshed on September 5, 2026.

Matching awards (last 2 FYs)
1,749
Full matching record count on RePORTER
Sampled funding
$93.1M
Sum of award amounts in the sample
Average award
$186K
Mean award amount in the sample

Example K08 projects from the sample

  • Role of stromal inflammatory signaling in the aging of lung resident lymphocytes

    5K08HL169723-04
    Nancy Allen · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA · $169,020 · awarded Aug 24, 2026 · NIH

    PROJECT SUMMARY Immune system dysfunction has been implicated in the pathogenesis of several age-related lung diseases. Interestingly, multiple recent studies have identified the tissue microenvironment as playing a critical role in the pathogenesis of some of these age-related immune system changes. The lung mesenchyme provides a supportive niche for the…

  • Digital Twins for Accelerating Clinical Trial Innovation in Alcohol-Associated Hepatitis

    1K08AA033404-01
    Joseph Ahn · MAYO CLINIC ROCHESTER, MN · $202,176 · awarded Aug 21, 2026 · NIH

    PROJECT SUMMARY Alcohol-associated hepatitis (AH) is a severe form of liver disease and a leading cause of liver-related mortality in the U.S., yet the therapeutic landscape remains critically underserved. Clinical trials for new AH therapies are profoundly impaired by low patient enrollment and poor retention, creating a major bottleneck that has stalled…

  • Immunosuppressive Neutrophils Modulate Alloimmune Responses After Lung Transplantation

    5K08HL181281-02
    Amit Bery · WASHINGTON UNIVERSITY, MO · $166,364 · awarded Aug 21, 2026 · NIH

    Project Summary/Abstract This proposal outlines a 5-year research and career development plan to support Dr. Amit Bery’s transition to independence as a physician-scientist studying how innate immune cells affect adaptive immunity after lung transplantation. The proposed research project, which focuses on how interleukin-1β (IL-1β) promotes the…

  • Partitioned polygenic risk scoring and machine learning-derived imaging phenotypes for discovery of novel mechanisms of cardiometabolic disease in people of South Asian ancestry

    1K08HL183778-01A1
    Romit Bhattacharya · MASSACHUSETTS GENERAL HOSPITAL, MA · $169,348 · awarded Aug 19, 2026 · NIH

    Project Summary / Abstract: Cardiovascular disease (CVD) is increasingly understood to be driven by metabolic dysfunction, as exemplified by the global epidemic of obesity and type 2 diabetes (T2D) and the risk conferred for myocardial infarction and heart failure. Individuals of South Asian ancestry face disproportionately high risks of myocardial…

  • Determining Protective Features of Human Memory T-cells to Inform Mycobacterium tuberculosis Vaccine Development

    5K08AI163407-05
    Stephen Carpenter · CASE WESTERN RESERVE UNIVERSITY, OH · $193,320 · awarded Aug 19, 2026 · NIH

    Project Summary / Abstract Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (Mtb), is a disease that kills 1.4 million people every year. There is no reliable vaccine to prevent TB, yet many latently-infected individuals are protected from progressing to active TB despite heavy Mtb exposure living in an endemic setting. CD4+ T cells…

  • Characterizing the immune infiltrate in muscle-invasive urothelial carcinoma

    5K08CA277016-04
    Katharine Collier · OHIO STATE UNIVERSITY, OH · $273,561 · awarded Aug 19, 2026 · NIH

    Project Summary Urothelial carcinoma is a common, aggressive, morbid, and understudied disease. Many patients are not cured with the current standard of care for localized muscle-invasive urothelial carcinoma, which is neoadjuvant combination cisplatin-based chemotherapy followed by radical cystectomy. But overall survival is significantly longer in…

  • Comparison of the Dysregulated and Regulated Host Responses to Infection

    5K08AI193352-02
    Grace Fisler · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, NY · $162,000 · awarded Aug 18, 2026 · NIH

    Project Summary/Abstract: Comparison of the regulated and dysregulated host response to infection Brief Background: Sepsis is life-threatening organ dysfunction caused by an extensively studied but poorly understood dysregulated host response to infection. Specific therapy has focused on modifying the sepsis- associated immune response; the failures of…

  • Novel mechanisms of acute myeloid leukemia resistance to cell therapy

    1K08CA304485-01A1
    ANAND BHAGWAT · CHILDREN'S HOSP OF PHILADELPHIA, PA · $263,656 · awarded Aug 17, 2026 · NIH

    Acute myeloid leukemia (AML) is a rapidly progressive cancer that occurs in children and adults and has no effective therapies for refractory disease. Chimeric antigen receptor T cell (CART) therapy has achieved impressive rates of response for some leukemias, but CART for AML has not been successful. We lack understanding of the ways AML evades killing by…

  • Muscle health and impaired glucose tolerance in adolescent and young adult hematopoietic cell transplantation survivors

    1K08CA304491-01A1
    RUSHA BHANDARI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE, CA · $280,931 · awarded Aug 17, 2026 · NIH

    PROJECT SUMMARY Adolescents and young adults (AYAs, 15–39 years old) with cancer undergoing allogeneic hematopoietic cell transplantation (HCT) are a growing population who have experienced inferior improvements in outcomes compared to younger non-AYAs. AYAs undergoing HCT are at high risk of developing treatment-related complications, attributed to the…

  • Role of the Choroid Plexus in Neutrophil Recruitment After Traumatic Brain Injury

    1K08NS148716-01
    Prajwal Ciryam · UNIVERSITY OF MARYLAND BALTIMORE, MD · $229,625 · awarded Aug 14, 2026 · NIH

    This is a proposal for a five-year research career development program focused on the role of the choroid plexus in neutrophil entry into the brain after traumatic brain injury (TBI). The principal investigator, Dr. Prajwal Ciryam, M.D., Ph.D., is an Assistant Professor and attending neurointensivist in the Department of Neurology and Program in Trauma at…

  • Clinical and biologic health trajectories after early life adversity

    5K08MH129657-05
    Barbara Chaiyachati · CHILDREN'S HOSP OF PHILADELPHIA, PA · $178,620 · awarded Aug 13, 2026 · NIH

    Project Summary/Abstract This career development award details a 5-year training plan to facilitate the transition of Dr. Barbara H. Chaiyachati to an independent career as a physician-scientist studying predictors of mental and physical health of children after trauma with an objective to identify actionable targets of intervention. Experiences of child…

  • The Interaction of Estradiol and Platelet Biology: A Mechanistic Exploration of Sex Dimorphisms in Coagulation

    5K08HL179469-02
    Julia Coleman · OHIO STATE UNIVERSITY, OH · $163,296 · awarded Aug 10, 2026 · NIH

    PROJECT SUMMARY/ABSTRACT Dr. Julia Coleman is establishing herself as an early-career, translational surgeon-scientist with expertise in trauma-induced coagulopathy (TIC), sex dimorphisms in platelet function, and their mechanistic underpinnings to improve the care of injured patients. This K08 award will provide her with the support necessary to accomplish…

Funding institutes in the sample

InstituteAwardsFunding
NIH494$92.2M
AHRQ6$892K

Most frequent institutions in the sample

  1. MASSACHUSETTS GENERAL HOSPITAL — 31 awards
  2. WASHINGTON UNIVERSITY — 30 awards
  3. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — 29 awards
  4. UNIVERSITY OF MICHIGAN AT ANN ARBOR — 25 awards
  5. YALE UNIVERSITY — 19 awards
  6. STANFORD UNIVERSITY — 18 awards
  7. JOHNS HOPKINS UNIVERSITY — 17 awards
  8. UNIVERSITY OF COLORADO DENVER — 15 awards

Source: NIH RePORTER. Verify any award in the official record by searching its project number. See our data methodology for how this sample is built and its limitations.

Decision guide

Choose K08 when

Choose K08 when you are a clinician with a PhD or equivalent research training planning a lab-based career.

Choose another mechanism when

For patient-oriented or clinical-trials research, choose K23. For combined approaches, check institute FOAs — some allow either.

Who applies for K08

Clinicians within ~5 years of completion of subspecialty training, who want a primary research focus on basic or translational lab science. K08 is the lab-research counterpart to the patient-oriented K23.

Compare nearby NIH grant mechanisms

Searchers often land on K08 while deciding between adjacent NIH activity codes. Compare scope, NIH staff involvement, budget scale, and applicant stage before choosing a funding opportunity.

For broad grant lookup, use the NIH grant search to find funded examples by activity code, PI, institution, and award year.

Search tips for K08

  • K08 awards are concentrated at academic medical centers — useful for tracking clinician-scientist talent pipelines.

Search NIH grants by activity code

Find K08-funded PIs

K08 funding trends

K08 frequently asked questions

What is the difference between K08 and K23?

K08 supports clinicians doing primarily lab-based or translational research. K23 supports clinicians doing patient-oriented research (clinical trials, observational studies, behavioral interventions). Both are mentored 3–5 year career development awards.

How much salary support does the K08 provide?

K08 salary support varies by institute and your institutional salary cap, but covers up to 75% effort. Most institutes cap K08 salary support around $100K–$130K/year.

Can I apply for an R01 while still on K08?

Yes — applying for R01 in the last 1–2 years of K08 is standard practice and expected. The K08 is designed to bridge to R01 independence.

Related NIH grant types