NIH Grant Search by PI — Funded Principal Investigator Finder

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Enter a research topic, disease, or technology to find principal investigators with NIH funding in that area. To look up a specific PI by name, use the PI Funding Status check.

Search Results

Found 189 principal investigators from 200 displayed projects for "K08" (2021–2026)

Note: 2,264 projects matched but only the first 200 were analyzed. Try narrowing your search with a more specific term or selecting "Project title only".

Opportunity Digest

Heuristic scoring to help trainees and job seekers prioritize which labs to inspect first.

3

High-opportunity leads

11

Likely hiring signals

157

Training-friendly awards

43

Average opportunity score

This search skews toward fellowships and mentored awards. It may be better for trainee funding or sponsor identification than direct job hunting.

Filter for opportunity type

Minseok Lee

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$813,999
FY 2026

Project Title

Stem Cell Impregnated Thread Reinforced Encapsulation Devices (THREDs) for Surgical Therapy of the Acute and Chronic Effects of Mesenteric Ischemia

Grant Number:

1R01DK145925-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY This investigator’s proposal describes a 5-year project of vertebral body derived mesenchymal stem cells within a Thread Reinforced Encapsulation Device (THRED) to treat the acute and long-term effects of mesenteric ischemia. The proposal evaluates intestinal organ recovery after tre...

Research Terms

<21+ years old><Abscission><Acute><Adult><Adult Human><After Care><After-Treatment><Aftercare><Aliquot><Allogeneic Transplantation><Allogenic><Anatomic Sites><Anatomic structures><Anatomy><Animals><Apoptosis><Apoptosis Pathway><Autologous><Award><Blood Vessels><Blood flow><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Therapy><Cells><Childhood><Chronic><Clinical Trials><Clotting><Coagulation><Coagulation Process><Collaborations><Cysteine><DNA mutation><Data><Devices><EGF><EGF gene><ENOS><Early-Stage Clinical Trials><Effectiveness><Emergencies><Emergency Situation><Emergent Technologies><Emerging Technologies><Encapsulated><Endogenous Nitrate Vasodilator><Endothelial Nitric Oxide Synthase><Endothelium-Derived Nitric Oxide><Ensure><Environment><Enzyme Gene><Enzymes><Excision><Extirpation><Free Radical Scavengers><Funding><Future><Gases><Gene Modified><Genetic Change><Genetic defect><Genetic mutation><Genome Instability><Genomic Instability><Goals><Gut Mucosa><Half-Cystine><Harvest><Health><Homologous Transplantation><Hospital Admission><Hospitalization><Hydrogen Sulfide><Immune><Immune destruction><Immune mediated destruction><Immune response><Immunes><Immunity><Implant><In Vitro><Inflammation><Infrastructure><Institution><Intestinal><Intestines><Intra-abdominal><Intracellular Communication and Signaling><Investigators><Ischemia><Ischemia-Reperfusion Injury><Ischemic Bowel Disease><L-Cysteine><Left><Location><Long-Term Effects><Mediating><Mediator><Membrane><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Mesenteric><Mesentery><Metabolic><Methodology><Methods><Mice><Mice Mammals><Modeling><Mononitrogen Monoxide><Morbidity><Murine><Mus><Mutation><NIDDK><NOS3><NOS3 gene><Nanoporous><National Institute of Diabetes and Digestive and Kidney Diseases><Necrosis><Necrotic><Nitric Oxide><Nitric Oxide Synthase 3><Nitrogen Monoxide><Nitrogen Protoxide><Nutrition><Operative Procedures><Operative Surgical Procedures><Organ><Patients><Perforation><Perfusion><Phase><Phase 1 Clinical Trials><Phase I Clinical Trials><Population><Preclinical Testing><Preclinical data><Progenitor Cells><Programmed Cell Death><Reaction><Recovery><Recovery of Function><Removal><Reperfusion Damage><Reperfusion Injury><Reperfusion Therapy><Research><Research Personnel><Researchers><Role><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Small Intestines><Source><Standardization><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><System><Testing><Therapeutic><Therapeutic Uses><Time><Transgenic Mice><Tumorigenicity><Type III nitric oxide synthase><Universities><VEGF><VEGFs><Vascular Endothelial Growth Factors><Vasodilatation><Vasodilation><Vasorelaxation><Vertebral Body><Veterinarians><Volatilization><absorption><adulthood><biological signal transduction><biomedical implant><bowel><bowel inflammation><career><cell based intervention><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><deceased donor><deceased organ donors><diagnostic tool><endothelial cell derived relaxing factor><experience><functional recovery><gastrointestinal transplantation><gene modification><genetically modified><genome mutation><gut inflammation><host response><immune system response><immunoresponse><implant device><implantable device><improved><indwelling device><inflamed bowel><inflamed gut><inflamed intestine><injury recovery><injury to the intestines><innovate><innovation><innovative><intestinal inflammation><intestinal injury><intestinal ischemia><intestine transplant><invention><long-term sequelae><membrane structure><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><mortality><new diagnostics><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation diagnostics><next generation therapeutics><novel><novel diagnostics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><overexpress><overexpression><paracrine><pediatric><pharmacologic><phase I protocol><pig model><piglet model><porcine model><post treatment><posthumous donors><posthumous organ donor><pre-clinical testing><preclinical findings><preclinical information><recovery after injury><recovery following injury><recovery post injury><reperfusion><resection><revascularization><small bowel><social role><stem cells><surgery><swine model><translational applications><vascular><vertebra body>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

TROY A MARKEL

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$813,999
FY 2026

Project Title

Stem Cell Impregnated Thread Reinforced Encapsulation Devices (THREDs) for Surgical Therapy of the Acute and Chronic Effects of Mesenteric Ischemia

Grant Number:

1R01DK145925-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY This investigator’s proposal describes a 5-year project of vertebral body derived mesenchymal stem cells within a Thread Reinforced Encapsulation Device (THRED) to treat the acute and long-term effects of mesenteric ischemia. The proposal evaluates intestinal organ recovery after tre...

Research Terms

<21+ years old><Abscission><Acute><Adult><Adult Human><After Care><After-Treatment><Aftercare><Aliquot><Allogeneic Transplantation><Allogenic><Anatomic Sites><Anatomic structures><Anatomy><Animals><Apoptosis><Apoptosis Pathway><Autologous><Award><Blood Vessels><Blood flow><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Therapy><Cells><Childhood><Chronic><Clinical Trials><Clotting><Coagulation><Coagulation Process><Collaborations><Cysteine><DNA mutation><Data><Devices><EGF><EGF gene><ENOS><Early-Stage Clinical Trials><Effectiveness><Emergencies><Emergency Situation><Emergent Technologies><Emerging Technologies><Encapsulated><Endogenous Nitrate Vasodilator><Endothelial Nitric Oxide Synthase><Endothelium-Derived Nitric Oxide><Ensure><Environment><Enzyme Gene><Enzymes><Excision><Extirpation><Free Radical Scavengers><Funding><Future><Gases><Gene Modified><Genetic Change><Genetic defect><Genetic mutation><Genome Instability><Genomic Instability><Goals><Gut Mucosa><Half-Cystine><Harvest><Health><Homologous Transplantation><Hospital Admission><Hospitalization><Hydrogen Sulfide><Immune><Immune destruction><Immune mediated destruction><Immune response><Immunes><Immunity><Implant><In Vitro><Inflammation><Infrastructure><Institution><Intestinal><Intestines><Intra-abdominal><Intracellular Communication and Signaling><Investigators><Ischemia><Ischemia-Reperfusion Injury><Ischemic Bowel Disease><L-Cysteine><Left><Location><Long-Term Effects><Mediating><Mediator><Membrane><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Mesenteric><Mesentery><Metabolic><Methodology><Methods><Mice><Mice Mammals><Modeling><Mononitrogen Monoxide><Morbidity><Murine><Mus><Mutation><NIDDK><NOS3><NOS3 gene><Nanoporous><National Institute of Diabetes and Digestive and Kidney Diseases><Necrosis><Necrotic><Nitric Oxide><Nitric Oxide Synthase 3><Nitrogen Monoxide><Nitrogen Protoxide><Nutrition><Operative Procedures><Operative Surgical Procedures><Organ><Patients><Perforation><Perfusion><Phase><Phase 1 Clinical Trials><Phase I Clinical Trials><Population><Preclinical Testing><Preclinical data><Progenitor Cells><Programmed Cell Death><Reaction><Recovery><Recovery of Function><Removal><Reperfusion Damage><Reperfusion Injury><Reperfusion Therapy><Research><Research Personnel><Researchers><Role><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Small Intestines><Source><Standardization><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><System><Testing><Therapeutic><Therapeutic Uses><Time><Transgenic Mice><Tumorigenicity><Type III nitric oxide synthase><Universities><VEGF><VEGFs><Vascular Endothelial Growth Factors><Vasodilatation><Vasodilation><Vasorelaxation><Vertebral Body><Veterinarians><Volatilization><absorption><adulthood><biological signal transduction><biomedical implant><bowel><bowel inflammation><career><cell based intervention><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><deceased donor><deceased organ donors><diagnostic tool><endothelial cell derived relaxing factor><experience><functional recovery><gastrointestinal transplantation><gene modification><genetically modified><genome mutation><gut inflammation><host response><immune system response><immunoresponse><implant device><implantable device><improved><indwelling device><inflamed bowel><inflamed gut><inflamed intestine><injury recovery><injury to the intestines><innovate><innovation><innovative><intestinal inflammation><intestinal injury><intestinal ischemia><intestine transplant><invention><long-term sequelae><membrane structure><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><mortality><new diagnostics><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation diagnostics><next generation therapeutics><novel><novel diagnostics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><overexpress><overexpression><paracrine><pediatric><pharmacologic><phase I protocol><pig model><piglet model><porcine model><post treatment><posthumous donors><posthumous organ donor><pre-clinical testing><preclinical findings><preclinical information><recovery after injury><recovery following injury><recovery post injury><reperfusion><resection><revascularization><small bowel><social role><stem cells><surgery><swine model><translational applications><vascular><vertebra body>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Minglin Ma

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$813,999
FY 2026

Project Title

Stem Cell Impregnated Thread Reinforced Encapsulation Devices (THREDs) for Surgical Therapy of the Acute and Chronic Effects of Mesenteric Ischemia

Grant Number:

1R01DK145925-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY This investigator’s proposal describes a 5-year project of vertebral body derived mesenchymal stem cells within a Thread Reinforced Encapsulation Device (THRED) to treat the acute and long-term effects of mesenteric ischemia. The proposal evaluates intestinal organ recovery after tre...

Research Terms

<21+ years old><Abscission><Acute><Adult><Adult Human><After Care><After-Treatment><Aftercare><Aliquot><Allogeneic Transplantation><Allogenic><Anatomic Sites><Anatomic structures><Anatomy><Animals><Apoptosis><Apoptosis Pathway><Autologous><Award><Blood Vessels><Blood flow><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Therapy><Cells><Childhood><Chronic><Clinical Trials><Clotting><Coagulation><Coagulation Process><Collaborations><Cysteine><DNA mutation><Data><Devices><EGF><EGF gene><ENOS><Early-Stage Clinical Trials><Effectiveness><Emergencies><Emergency Situation><Emergent Technologies><Emerging Technologies><Encapsulated><Endogenous Nitrate Vasodilator><Endothelial Nitric Oxide Synthase><Endothelium-Derived Nitric Oxide><Ensure><Environment><Enzyme Gene><Enzymes><Excision><Extirpation><Free Radical Scavengers><Funding><Future><Gases><Gene Modified><Genetic Change><Genetic defect><Genetic mutation><Genome Instability><Genomic Instability><Goals><Gut Mucosa><Half-Cystine><Harvest><Health><Homologous Transplantation><Hospital Admission><Hospitalization><Hydrogen Sulfide><Immune><Immune destruction><Immune mediated destruction><Immune response><Immunes><Immunity><Implant><In Vitro><Inflammation><Infrastructure><Institution><Intestinal><Intestines><Intra-abdominal><Intracellular Communication and Signaling><Investigators><Ischemia><Ischemia-Reperfusion Injury><Ischemic Bowel Disease><L-Cysteine><Left><Location><Long-Term Effects><Mediating><Mediator><Membrane><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Mesenteric><Mesentery><Metabolic><Methodology><Methods><Mice><Mice Mammals><Modeling><Mononitrogen Monoxide><Morbidity><Murine><Mus><Mutation><NIDDK><NOS3><NOS3 gene><Nanoporous><National Institute of Diabetes and Digestive and Kidney Diseases><Necrosis><Necrotic><Nitric Oxide><Nitric Oxide Synthase 3><Nitrogen Monoxide><Nitrogen Protoxide><Nutrition><Operative Procedures><Operative Surgical Procedures><Organ><Patients><Perforation><Perfusion><Phase><Phase 1 Clinical Trials><Phase I Clinical Trials><Population><Preclinical Testing><Preclinical data><Progenitor Cells><Programmed Cell Death><Reaction><Recovery><Recovery of Function><Removal><Reperfusion Damage><Reperfusion Injury><Reperfusion Therapy><Research><Research Personnel><Researchers><Role><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Small Intestines><Source><Standardization><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><System><Testing><Therapeutic><Therapeutic Uses><Time><Transgenic Mice><Tumorigenicity><Type III nitric oxide synthase><Universities><VEGF><VEGFs><Vascular Endothelial Growth Factors><Vasodilatation><Vasodilation><Vasorelaxation><Vertebral Body><Veterinarians><Volatilization><absorption><adulthood><biological signal transduction><biomedical implant><bowel><bowel inflammation><career><cell based intervention><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><deceased donor><deceased organ donors><diagnostic tool><endothelial cell derived relaxing factor><experience><functional recovery><gastrointestinal transplantation><gene modification><genetically modified><genome mutation><gut inflammation><host response><immune system response><immunoresponse><implant device><implantable device><improved><indwelling device><inflamed bowel><inflamed gut><inflamed intestine><injury recovery><injury to the intestines><innovate><innovation><innovative><intestinal inflammation><intestinal injury><intestinal ischemia><intestine transplant><invention><long-term sequelae><membrane structure><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><mortality><new diagnostics><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation diagnostics><next generation therapeutics><novel><novel diagnostics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><overexpress><overexpression><paracrine><pediatric><pharmacologic><phase I protocol><pig model><piglet model><porcine model><post treatment><posthumous donors><posthumous organ donor><pre-clinical testing><preclinical findings><preclinical information><recovery after injury><recovery following injury><recovery post injury><reperfusion><resection><revascularization><small bowel><social role><stem cells><surgery><swine model><translational applications><vascular><vertebra body>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Dana Alexa Telem

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$610,703
FY 2026

Project Title

Combining Policy and Implementation Science to Optimize Clinical Practice

Grant Number:

5R01DK128179-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2022

End Date:

2/28/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY ABSTRACT: Changing clinician practice is difficult but important. Traditionally, strategies to attain sustainable practice change have followed one of two general paths: financial incentives and practice redesign and implementation. Financial incentives, while often effective in aggr...

Research Terms

<AHCPR><AHRQ><Abdominal Hernia><Adherence><Adopted><Agency for Health Care Policy and Research><Agency for Healthcare Research and Quality><Award><Blood Glucose><Blood Sugar><Case Study><Case-Base Studies><Cessation of life><Clinical><Corporate Culture><Day Surgery><Death><Diabetes Mellitus><Education><Educational aspects><Ensure><Evaluation><Evidence based practice guidelines><Goals><Guideline Adherence><Guidelines><Health Care><Health system><Hernia><Hernia of abdominal cavity><Hospitals><Incentives><Individual><Interruption><Intervention><Knowledge><Maps><Measures><Methods><Michigan><Modeling><Morbid Obesity><Morbidity><Natural experiment><Operative Procedures><Operative Surgical Procedures><Organizational Change><Organizational Culture><Patients><Pattern><Performance><Persons><Physicians><Policies><Policy Analyses><Policy Analysis><Population><Practice Management><Principal Investigator><Provider><Randomized><Registries><Research><Research Resources><Resource Allocation><Resources><Sequential Multiple Assignment Randomized Trial><Services><Severe obesity><Site><Smoking><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Surgical complication><System><Testing><Theoretical Domains framework><Time Series Analysis><United States Agency for Health Care Policy and Research><United States Agency for Healthcare Research and Quality><Work><Writing><abdominal wall><adherence rate><assess effectiveness><behavior change><care costs><case report><cease smoking><clinical practice><clinician behavior><compare effectiveness><cost effective><design><designing><determine effectiveness><diabetes><effectiveness assessment><effectiveness evaluation><effectiveness testing><evaluate effectiveness><evidence base><evidence based guidelines><evidence based recommendations><examine effectiveness><extreme obesity><financial incentive><financial reward><high risk><hospital performance><implementation cost><implementation investment><implementation science><implementation strategy><improved><improved outcome><innovate><innovation><innovative><intervention cost><monetary incentive><novel><obesity management><payment><physician behavior><policy evaluation><primary outcome><programs><provider behavior><quit smoking><randomisation><randomization><randomly assigned><remediation><repair><repaired><response><secondary outcome><smoking cessation><stop smoking><strategies for implementation><surgery><surgery complication><surgery risk><surgical risk><tool><trial design>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Russell Gardner Witt

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Good lead · 66/100
Training-friendly
Solid budget
Very recent
Active award
$291,498
FY 2026

Project Title

Investigating the Impact of Obesity and Androgen Receptor Signaling on BRAF/MEKi Resistance in Melanoma

Grant Number:

1K08CA301024-01A1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2031

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY As a surgical oncologist at the University of Virginia, I strive not only to deliver excellent surgical care but also to understand the mechanisms underlying treatment resistance in melanoma. My research focuses on the phenomenon known as the “obesity paradox,” where obese individual...

Research Terms

<Acceleration><Address><Advisory Committees><Affect><Androgen Receptor><Androgenic Agents><Androgenic Compounds><Androgens><Apoptosis><Apoptosis Pathway><Automobile Driving><Autoregulation><Award><B-raf-1><BMI><BMI percentile><BMI z-score><BRAF><BRAF gene><Biological><Biometrics><Biometry><Biostatistics><Blood Serum><Body mass index><C-jun Amino-Terminal Kinase><C-jun Kinase-1><C-jun N-Terminal Kinase 1><Cancer Biology><Cancer Treatment><Caring><Cell Communication and Signaling><Cell Signaling><Chronic><Clinical><Clinical Data><Clinical Research><Clinical Study><Communication><Complement><Complement Proteins><Data><Dependence><Development Plans><Diet><Disease Progression><ER stress><Endoplasmic Reticulum><Ensure><Ergastoplasm><Exhibits><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Foundations><Free Fatty Acids><Funding><Gene Expression><Glycolysis><Goals><Homeostasis><Human><Impairment><In Vitro><Individual><Inflammation><Inflammatory><Intermediary Metabolism><Intracellular Communication and Signaling><Investigators><Iris><JN Kinase><JNK><JNK Mitogen-Activated Protein Kinases><JNK1><JNK1 Kinase><JNK1 protein><JNK1A2><JNK21B1/2><Knowledge><Leanness><Learning><Link><MAP Kinase 8><MAP Kinase 8 Gene><MAPK8><MAPK8 Mitogen-Activated Protein Kinase><MAPK8 gene><MEKs><Malignant Melanoma><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Skin Neoplasm><Mechanistic Target of Rapamycin><Mediating><Mediator><Melanoma><Melanoma Cell><Melanoma Tumor><Mentors><Mentorship><Messenger RNA><Metabolic><Metabolic Processes><Metabolic stress><Metabolism><Mice><Mice Mammals><Mitogen-Activated Protein Kinase 8><Modern Man><Murine><Mus><Mutate><NIH><National Institutes of Health><Nonesterified Fatty Acids><Obese Mice><Obesity><Oncologic Surgeon><Operative Procedures><Operative Surgical Procedures><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><PRKM8><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Physiological Homeostasis><Programmed Cell Death><Progression-Free Survivals><Proteins><Public Health><Quetelet index><RAFB1><RAFT1><RNA Splicing><Receptor Signaling><Recurrence><Recurrent><Research><Research Personnel><Researchers><Resistance><SAP Kinase-1><SAPK/JNK><SAPK1 Mitogen-Activated Protein Kinase><SAPK1/JNK><Sampling><Scientist><Serum><Signal Transduction><Signal Transduction Systems><Signaling><Skin Cancer><Splicing><Stress><Stress-Activated Protein Kinase JNK1><Stress-Activated Protein Kinase gamma><Structure><Subgroup><Surgeon><Surgical><Surgical Interventions><Surgical Oncologist><Surgical Procedure><TRAF2><TRAF2 gene><TRAP3><Task Forces><Techniques><Testing><Therapeutic Androgen><Thinness><Tumor growth in melanoma><United States National Institutes of Health><Universities><Variant><Variation><Virginia><Weight><Work><XBP1><XBP1 gene><adiposity><advisory team><aerobic glycolysis><analyze microbiome><androgen ablation therapy><androgen blockade therapy><androgen deprivation therapy><androgen deprivation treatment><anti-cancer therapy><biologic><biological adaptation to stress><biological signal transduction><c-jun N-Terminal Kinase><cancer cell metabolism><cancer metabolism><cancer therapy><cancer-directed therapy><career><career development><clinical validation><complementation><corpulence><cytokine><design><designing><diet-associated obesity><diet-induced obesity><diet-related obesity><diets><driving><endoplasmic reticulum stress><experience><fatty acid oxidation><flexibility><flexible><hormonal signals><hormone signals><improved><in vitro Model><in vivo><in vivo Model><inhibitor><inhibitor drug><inhibitor therapeutic><inhibitor therapy><jun-NH2-Terminal Kinase><mRNA><mTOR><male><malignant skin tumor><mammalian target of rapamycin><melanoma cancer model><melanoma model><melanoma tumor model><men><metabolism measurement><metabolomics><metabonomics><microbiome><microbiome analysis><mouse model><murine model><mutant><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><ob/ob mouse><obese individuals><obese patients><obese people><obese person><obese population><obese subjects><pathway><patient oriented outcomes><patients with obesity><pharmacologic><preservation><reactioncrisis><receptor expression><resistance to therapy><resistant><resistant to therapy><response><response to therapy><response to treatment><sex><sex dimorphism><sexual dimorphism><sexually dimorphic><skills><statistics><stress response><stress-activated protein kinase 1><stressreaction><success><surgery><therapeutic resistance><therapeutic response><therapy resistant><therapy response><treatment resistance><treatment response><treatment responsiveness><tumor><tumor cell metabolism><tumor growth><tumor metabolism><v-raf Murine Sarcoma Viral Oncogene Homolog B1><weights><♂>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ami B Patel

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Good lead · 66/100
Training-friendly
Solid budget
Very recent
Active award
$289,908
FY 2026

Project Title

Mechanisms of resistance to MEK Inhibition in RAS-pathway activated chronic myelomonocytic leukemia

Grant Number:

5K08CA252883-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/1/2022

End Date:

4/30/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Overview: The goal of this award is to provide Dr. Ami Patel with the training and mentored research experience to ensure success in her transition to an independent investigator with expertise in the biology and treatment of myeloid malignancies. Dr. Patel’s long term goal ...

Research Terms

<AML - Acute Myeloid Leukemia><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Address><Affect><Allogenic><Award><Bioinformatics><Biology><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone marrow failure><C-K-RAS><CBL><CBL gene><CBL2><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancer Treatment><Cancers><Career Mobility><Cas nuclease technology><Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><CellLine><Cells><Chronic Myelomonocytic Leukemia><Clinical><Clinical Investigator Award><Clinical Trials><Clinical Trials Design><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Comprehensive Cancer Center><Correlative Study><Cytokine Receptors><DNA mutation><Dedications><Development><Disease><Disease remission><Disorder><Drug Targeting><Drug resistance><Drugs><Dysplasia><EPH- and ELK-Related Tyrosine Kinase><EPH-and ELK-Related Kinase><Elderly><Eligibility><Eligibility Determination><Ensure><Environment><Ephrin Type-A Receptor 8><Ephrin Type-A Receptor 8 Precursor><Exhibits><Exposure to><FLK2><FLT3><FLT3 gene><FMS-like tyrosine kinase 3><Fms-Related Tyrosine Kinase 3><Future><Gene Alteration><Gene Mutation><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematologist><Hematopoietic Cancer><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><In Vitro><In complete remission><Individual><Institution><International><Interruption><Intracellular Communication and Signaling><Investigation><Investigators><JAK-2><JAK2><JAK2 gene><JAK2 protein><Janus kinase 2><K-RAS2A><K-RAS2B><K-Ras><K-Ras 2A><K-Ras-2 Oncogene><K08 Mechanism><K08 Program><KRAS><KRAS2><KRAS2 gene><Ki-RAS><Kinases><Laboratories><Leukemic Cell><MAP Kinase Kinases><MAP kinase><MAPK Kinases><MAPKKs><Malignant Hematologic Neoplasm><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Medication><Mentors><Methodology><Mice><Mice Mammals><Mitogen-Activated Protein Kinase Kinases><Mitogen-Activated Protein Kinases><Mitogens><Molecular Target><Murine><Mus><Mutate><Mutation><Myelogenous><Myeloid><Myeloid Disease><Myeloid Malignancy><Myeloid Neoplasm><Myeloid Tumor><Myeloproliferative Disorders><Myeloproliferative Tumors><Myeloproliferative disease><NF-1><NF-1 Protein><NF-1 encoded protein><NF1><NF1 GRP><NF1 Protein><NF1 gene><NF1-GAP-Related Protein><Neurofibromatosis 1 Genes><Neurofibromatosis Type 1 Gene Product><Neurofibromatosis Type 1 Protein><Neurofibromin><Neurofibromin 1><Non-Receptor Type 11 Protein Tyrosine Phosphatase><Oncogene K-Ras><Oncologist><Oral><PDX model><PTP-2 enzyme><PTP2C><PTPN11><PTPN11 gene><Pathway interactions><Patient derived xenograft><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pharmaceutical Preparations><Phase 1/2 trial><Phase 2 Clinical Trials><Phase I/II Trial><Phase II Clinical Trials><Phosphotransferase Gene><Phosphotransferases><Physicians><Pre-Clinical Model><Preclinical Models><Progenitor Cell Transplantation><Proliferating><Protein Tyrosine Kinase><Protein Tyrosine Kinase EEK><Protein Tyrosine Phosphatase 2C><Protein-Tyrosine Phosphatase 2C><Protocol Screening><RASK2><RNA Seq><RNA sequencing><RNAseq><Ras Inhibitor><Receptor Signaling><Refractory><Relapse><Remission><Research><Research Personnel><Research Proposals><Researchers><Resistance><SHP2><SHP2 Phosphatase><SHPTP2><STK-1 kinase><STK1><Sampling><Scientist><Shp-2 tyrosine phosphatase><Signal Transduction><Signal Transduction Systems><Signaling><Site><Somatic Mutation><Source><Stem Cell Transplantation><Stem Cell Tyrosine Kinase 1><Stem cell transplant><Strains Cell Lines><Structure><Symptoms><Techniques><Testing><Therapeutic><Time><Training><Translational Research><Translational Research Enterprise><Translational Science><Transphosphorylases><Transplantation><Tyrosine Kinase><Tyrosine Phosphatase SHP2><Tyrosine-Protein Kinase JAK2><Tyrosine-Protein Kinase Receptor EEK><Tyrosine-Specific Protein Kinase><Tyrosylprotein Kinase><Universities><Utah><Validation><acute granulocytic leukemia><acute granulocytic leukemia cell><acute myeloblastic leukemia cell><acute myelocytic leukemia cell><acute myelogenous leukemia cell><acute myeloid leukemia><acute myeloid leukemia cell><acute nonlymphocytic leukemia cell><advanced age><anti-cancer therapy><biological signal transduction><biomarker identification><cancer drug resistance><cancer therapy><cancer-directed therapy><career><career advancement><career development><career transition><clinical investigation><clinical trial implementation><cohort><combinatorial><complete response><cultured cell line><design><designing><develop drug resistance><developmental><disease risk><disorder risk><drug resistance development><drug resistant><drug/agent><dyscrasia><effective therapy><effective treatment><efficacy testing><exome sequencing><exome-seq><experience><fetal liver kinase-2><fetal liver kinase-3><gene defect><genome editing><genome mutation><genomic editing><geriatric><high risk><hydroxyaryl protein kinase><identification of biomarkers><identification of new biomarkers><implementation of clinical trials><improved><in vivo><inhibitor><kinase inhibitor><malignancy><marker identification><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><mortality><mutant allele><myeloproliferative neoplasm><neoplasm/cancer><neurofibromatosis type 1 gene><neurofibromatosis type 1 protein/gene><nf 1 Genes><novel><older adult><older adulthood><open label><open label study><pathway><patient derived xenograft model><patient oriented outcomes><phase 2 study><phase II protocol><phase II study><pre-clinical study><preclinical study><prevent><preventing><progenitor transplantation><programs><rational design><resistance mechanism><resistance to Drug><resistance to cancer drugs><resistant><resistant mechanism><resistant to Drug><resistant to cancer drugs><response><response to therapy><response to treatment><senior citizen><shRNA><short hairpin RNA><skills><small hairpin RNA><somatic variant><standard care><standard treatment><stem and progenitor cell transplantations><success><survival outcome><targeted agent><therapeutic response><therapy response><transcriptome sequencing><transcriptomic sequencing><translation research><translation research enterprise><translational investigation><translational research program><transplant><treatment response><treatment responsiveness><treatment strategy><tyrosyl protein kinase><v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog><validations>
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Siyuan John Liu

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100
Training-friendly
Solid budget
Very recent
Active award
$286,881
FY 2026

Project Title

Defining the cell intrinsic and tumor immune microenvironment mechanisms of DNA-PKcs in radiotherapy resistance in glioblastoma

Grant Number:

1K08CA304353-01A1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2031

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The goal of this K08 Career Development Award is to train Dr. S. John Liu, a second year Assistant Professor in Residence at UCSF, in the skills he will need to become an independently funded physician-scientist capable of basic and translational investigation in neuro-oncology. Dr. ...

Research Terms

<Animal Model><Animal Models and Related Studies><Area><Assay><Award><Binding><Bioassay><Biological Assay><Biometrics><Biometry><Biostatistics><Brain Cancer><Brain Neoplasia><Brain Neoplasms><Brain Tumors><CRISPR approach><CRISPR based approach><CRISPR editing screen><CRISPR interference><CRISPR method><CRISPR methodology><CRISPR screen><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based screen><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR-dCas9-mediated repression><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 screen><CRISPR/Cas9 technology><CRISPR/dCas9 interference><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRi><Cancers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cas nuclease technology><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Reprogramming><Cell Signaling><Cell Survival><Cell Viability><Cell-to-Cell Interaction><Cells><Chemotherapy and Radiation><Chemotherapy and/or radiation><Chromatin><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats interference><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Co-culture><Cocultivation><Coculture><Coculture Techniques><Combined Modality Therapy><Complex><Comprehensive Cancer Center><Coupling><DNA Binding><DNA Binding Interaction><DNA Damage><DNA Damage Repair><DNA Injury><DNA Molecular Biology><DNA Repair><DNA bound><DNA dependent protein kinase catalytic subunit><DNA-PKcs><Data><Dependence><Development><Development and Research><Diagnosis><Disease><Disorder><Educational workshop><Exhibits><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Funding><Gene Expression><Gene Transcription><Generalized Growth><Genes><Genetic><Genetic Transcription><Genomics><Glioblastoma><Goals><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><Growth><Heterogeneity><Heterograft><Heterologous Transplantation><High Throughput Assay><Histology><Human><IFN><Immune><Immune signaling><Immunes><Immunochemical Immunologic><Immunocompetent><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunologic><Immunologic Model><Immunological><Immunological Models><Immunologically><Immunologics><Immunomodulation><Immunosuppressed Host><Impairment><In Vitro><Inflammatory><Interferon Suppression><Interferons><International><Intracellular Communication and Signaling><Investigation><K-Awards><K-Series Research Career Programs><Kinases><Knowledge><Laboratories><Leadership><Malignant><Malignant - descriptor><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Brain><Malignant neoplasm of brain><Mediating><Mentors><Methods><Mice><Mice Mammals><Modern Man><Molecular><Molecular Biology><Molecular Interaction><Multimodal Therapy><Multimodal Treatment><Murine><Mus><NCCN><National Comprehensive Cancer Network><Neurological Surgery><Neurosurgical Procedures><Oncogenesis><Pathology><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phenotype><Phosphotransferase Gene><Phosphotransferases><Physicians><Postoperative><Postoperative Period><Pre-Clinical Model><Preclinical Models><Proteins><Publishing><R & D><R&D><RNA Expression><Radiation Biology><Radiation Oncology><Radiation therapy><Radiobiology><Radiosensitization><Radiotherapeutics><Radiotherapy><Recurrent Neoplasm><Recurrent tumor><Regulation><Reporting><Research><Research Career Program><Research Methodology><Research Methods><Research Proposals><Research Specimen><Resistance><Role><STING agonists><Science><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Specimen><Stimulator of Interferon Genes><Technology><Temodal><Temodar><Testing><Tissue Growth><Training><Transcription><Transcription Activation><Transcriptional Activation><Transcriptional Control><Transcriptional Regulation><Translational Research><Translational Science><Translations><Transphosphorylases><Tumor Cell><Tumor-infiltrating immune cells><Unscheduled DNA Synthesis><Variant><Variation><Vertebrate Animals><Vertebrates><Work><Workshop><Xenograft><Xenograft procedure><Xenotransplantation><anti-tumor effect><antitumor effect><associate faculty><associate professor><attenuation><biological signal transduction><cGAMP STING><cGAMP-STING><cGAMP/STING><cGAS/STING><cancer cell><cancer immunology><career><career development><cellular reprogramming><chemo-/radio-sensitization><chemo/radiation therapy><chemotherapy><chemotherapy and radiotherapy><clustered regularly interspaced short palindromic repeats screen><combination therapy><combined modality treatment><combined treatment><conference><convention><cyclic GMP-AMP synthase/STING><developmental><experience><experiment><experimental research><experimental study><experiments><flow cytophotometry><functional genomics><genome scale><genome-wide><genomewide><genomic tools><glioblastoma multiforme><hands on research><high throughput screening><immune cell infiltration of tumors><immune cells infiltrating the tumor><immune cells that infiltrate the tumor><immune competent><immune microenvironment><immune modulation><immune regulation><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunosuppressed patient><immunosuppressive microenvironment><immunosuppressive tumor microenvironment><improved><improved outcome><in vitro Model><in vivo><infiltration of tumors by immune cells><intratumoral immune cell><intratumoral immune infiltrate><malignancy><methazolastone><mid-career faculty><midcareer faculty><model of animal><mouse model><multi-modal therapy><multi-modal treatment><murine model><neoplasm immunology><neoplasm recurrence><neoplasm/cancer><neoplastic cell><neuro-oncology><neurooncology><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ontogeny><pathway><patient oriented outcomes><pharmacologic><professor><radiation or chemotherapy><radiation sensitization><radiation treatment><radio-/chemo-sensitization><radio-sensitization><radiotherapy sensitization><recruit><repair><repaired><repressing CRISPR-dCas9 system><research and development><research and methods><residence><residential building><residential site><resistance mechanism><resistant><resistant mechanism><sNuc-Seq><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single nucleus RNA-sequencing><single nucleus seq><single-cell RNA sequencing><single-nucleus RNA-seq><skills><small molecule><snRNA sequencing><snRNA-seq><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><spongioblastoma multiforme><standard of care><summit><symposia><symposium><temozolomide><therapeutic target><translation><translation research><translational investigation><treatment with radiation><tumor><tumor growth><tumor immune cell><tumor immune infiltrate><tumor immune microenvironment><tumor immunology><tumor infiltration of immune cells><tumor-immune system interactions><tumorigenesis><tumors in the brain><vertebrata><xeno-transplant><xeno-transplantation>
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Jacob Soumerai

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100
Training-friendly
Solid budget
Very recent
Active award
$285,931
FY 2026

Project Title

Predictive markers for personalized therapy in chronic lymphocytic leukemia

Grant Number:

5K08CA270202-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Candidate. Jacob D. Soumerai, MD is an Assistant Professor of Medicine at Harvard Medical School (HMS) and Hematologist/Medical Oncologist at Massachusetts General Hospital (MGH) who conducts mentored clinical research in lymphoma and chronic lymphocytic leukemia (CLL). His ...

Research Terms

<17p><Abbreviations><Achievement><Achievement Attainment><Address><After Care><After-Treatment><Aftercare><Anemia><Antibodies><Antioncogene Protein p53><Assay><B cell lymphoma 2><B-Cell CLL><B-Cell CLL/Lymphoma 2 Gene><B-Cell Chronic Lymphocytic Leukemia><B-Cell Chronic Lymphogenous Leukemia><B-Cell Chronic Lymphoid Leukemia><B-Cell Lymphocytic Leukemia><B-Lymphocytic Leukemia><B-cell lymphoma/leukemia-2><BCL2><BCL2 gene><Bcl-2><Bioassay><Biological Assay><Biological Markers><Biometrics><Biometry><Biostatistics><Bone Marrow><Bone Marrow Reticuloendothelial System><Bp35><CAPP-seq><CD20><Cancer Personalized Profiling by Deep Sequencing><Cellular Tumor Antigen P53><Chromosome 17 Proximal Arm><Chromosome 17 Short Arm><Chromosome 17p><Chronic B-Lymphocytic Leukemia><Chronic Lymphatic Leukemia><Chronic Lymphoblastic Leukemia><Chronic Lymphocytic Leukemia><Chronic Lymphogenous Leukemia><Clinical><Clinical Research><Clinical Study><Clinical Trials><Clonal Evolution><DNA mutation><Data><Detectable Residual Disease><Detection><Development><Development Plans><Disease remission><Doctor of Philosophy><EC 1.1.1.27><Ensure><Evaluation><Failure><Fellowship><Funding><General Hospitals><Genetic Change><Genetic defect><Genetic mutation><Germinoblastic Sarcoma><Germinoblastoma><Globulins><Goals><Health><Hematologist><Investigators><Kinetics><Knowledge><L-Lactate Dehydrogenase><L-Lactic Acid Dehydrogenase><Lactate Dehydrogenase><Leu-16><Lymphoma><MS4A1><MS4A1 gene><MS4A2><Malignant Lymphoma><Massachusetts><Medical Oncologist><Medicine><Mentors><Mentorship><Minimal Residual Disease><Mission><Mutation><NAD-Lactate Dehydrogenase><Oncoprotein p53><P53><Patient Care><Patient Care Delivery><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Persons><Ph.D.><PhD><Phase><Phosphoprotein P53><Phosphoprotein pp53><Position><Positioning Attribute><Procedures><Protein TP53><Public Health><Recurrent disease><Relapse><Relapsed Disease><Remission><Research><Research Personnel><Researchers><Residual Neoplasm><Residual Tumors><Resistance><Reticulolymphosarcoma><Retreatment><Risk><Risk Factors><Sampling><Scientific Advances and Accomplishments><Serum Globulins><TP53><TP53 gene><TRP53><Technical Expertise><Techniques><Testing><Therapeutic><Time><Training><Training Activity><Translations><Treatment Efficacy><Treatment Period><Tumor Protein p53><Tumor Protein p53 Gene><Variant><Variation><assay development><bcl-2 Genes><bio-markers><biologic marker><biomarker><biomarker development><biomarker validation><care for patients><care of patients><career><career development><caring for patients><ced9 homolog><chronic lymphoid leukemia><clinical translation><clinical validation><clinically translatable><detection limit><developmental><experience><genome mutation><genomic predictors><genomic signature><high risk><improved><improved outcome><inhibitor><inhibitor drug><inhibitor therapeutic><inhibitor therapy><intervention efficacy><lactic acid dehydrogenase><leukemia treatment><leukemic therapy><marker validation><medical college><medical schools><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><p53 Antigen><p53 Genes><p53 Tumor Suppressor><patient oriented outcomes><peripheral blood><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><phase 2 trial><phase II trial><post treatment><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><predictive signature><professor><prognosis model><prognostic model><programs><prospective><protein p53><re-treatment><relapse patients><residual disease><resistance mechanism><resistant><resistant mechanism><response biomarker><response markers><school of medicine><scientific accomplishments><scientific advances><skills><success><targeted sequencing><technical skills><therapeutic efficacy><therapy duration><therapy efficacy><training module><translation><treatment days><treatment duration><tumor DNA><tumor cell DNA><tumor-specific DNA>
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Miranda Lam

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 66/100
Training-friendly
Solid budget
Very recent
Active award
$270,971
FY 2026

Project Title

Assessing Variation in Outcomes for Cancer Patients Receiving Radiation Treatments and Identifying High-Value Radiation Oncology Practices

Grant Number:

5K08CA273549-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2023

End Date:

4/30/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract The overall goal of this NCI K08 career development proposal is to facilitate Dr. Miranda Lam’s development into an independent investigator in oncology health policy research focused on understanding factors and policies that impact the quality and cost of cancer care. Her ...

Research Terms

<Affect><Area><Cancer Patient><Cancer Radiotherapy><Cancer Treatment><Cancers><Caring><Centers for Medicare and Medicaid Services><Characteristics><Clinical><Country><Data><Development><Disparities><Disparity><ED visit><ER visit><Educational process of instructing><Emergency care visit><Emergency department visit><Emergency hospital visit><Emergency room visit><Ensure><Evaluation><Financial Hardship><Future><Goals><Health Care><Health Care Financing Administration><Health Care Providers><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Health Personnel><Health Policy><Hospitals><Incentives><Inequity><Interview><Investigators><Leadership><Link><Low income><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Measures><Medicaid><Medicare><Medicare claim><Medicare/Medicaid><Methods><Modeling><Oncology><Oncology Cancer><Outcome><Patient Care><Patient Care Delivery><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Physicians><Policies><Policy Maker><Policy Research><Population><Position><Positioning Attribute><Privatization><Provider><Public Health><QOC><Qualitative Methods><Quality of Care><Radiation Oncologist><Radiation Oncology><Radiation therapy><Radiotherapeutics><Radiotherapy><Randomized><Research><Research Personnel><Research Proposals><Researchers><Savings><Scientist><Shapes><System><Teaching><Time><Title 18><United States><United States Centers for Medicare and Medicaid Services><United States Health Care Financing Administration><Variant><Variation><Vulnerable Populations><anti-cancer therapy><beneficiary><cancer care><cancer disparity><cancer health disparity><cancer radiation therapy><cancer therapy><cancer type><cancer-directed therapy><cancer-related health disparity><care delivery><care for patients><care of patients><care providers><career development><caring for patients><chemotherapy><cost><developmental><disabled><disparity in cancer><disparity in care><disparity in health care><dual eligible><economic hardship><economic strain><financial adversity><financial burden><financial distress><financial insecurity><financial instability><financial strain><financial stress><financial worry><health care disparity><health care inequality><health care inequity><health care personnel><health care policy><health care worker><health insurance for disabled><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><improved><informant><insight><interest><malignancy><medical care providers><medical personnel><neoplasm/cancer><older adult><older adulthood><oncology service><patient oriented outcomes><payment><programs><prospective><qualitative reasoning><radiation delivery><radiation treatment><randomisation><randomization><randomly assigned><safety net><success><treatment provider><treatment with radiation><value based health care><value based model of care><value driven care><value-based care><vulnerable group><vulnerable individual><vulnerable people>
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TROY A MARKEL

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$415,582
FY 2026

Project Title

Sulfur Based Stem Cell Therapeutics in Necrotizing Enterocolitis

Grant Number:

5R01DK133418-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

This investigator's proposal describes a 5-year project designed to study mesenchymal stem cells derived from inducible pluripotent stem cells as a treatment modality for necrotizing enterocolitis (NEC). NEC is a devastating intrabdominal emergency in the neonatal population that often requires the ...

Research Terms

<Abdomen><Abscission><Angiogenesis Modulating Agents><Angiogenesis Modulators><Animals><Apoptosis><Apoptosis Pathway><Assay><Award><Bioassay><Biological Assay><Blood flow><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Culture System><Cell Growth in Number><Cell Locomotion><Cell Migration><Cell Movement><Cell Multiplication><Cell Proliferation><Cell Signaling><Cell Therapy><Cells><Cellular Migration><Cellular Motility><Cellular Proliferation><Cessation of life><Childhood><Clinical><Clinical Trials><Collaborations><DNA mutation><Death><Death Rate><Degenerative Arthritis><Degenerative polyarthritis><Detection><Development><Diabetic Foot Ulcer><ENOS><Emergencies><Emergency Situation><Endogenous Nitrate Vasodilator><Endothelial Nitric Oxide Synthase><Endothelium><Endothelium-Derived Nitric Oxide><Enzyme Gene><Enzyme Precursors><Enzymes><Equilibrium><Esters><Evaluation><Excision><Exhibits><Extirpation><Funding><GI microbiome><Gases><Generations><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><Grant><Gut Mucosa><GvHD><Harvest><Homologous Wasting Disease><Human><Hydrogen Sulfide><Hypoxia><Hypoxic><IND Filing><IND application><IND package><IND submission><Immune><Immunes><In Situ><In Vitro><Infant><Inflammatory Response><Infrastructure><Infusion><Infusion procedures><Institution><International><Intestinal><Intestines><Intra-abdominal><Intracellular Communication and Signaling><Investigational New Drug Application><Investigators><Ischemia><Laboratories><Length><Measures><Mediating><Mediator><Medical><Medical Care Costs><Mentors><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Mesenteric><Mesentery><Methods><Mice><Mice Mammals><Modality><Modeling><Modern Man><Mononitrogen Monoxide><Murine><Mus><Mutation><Myography><NIDDK><NOS3><NOS3 gene><National Institute of Diabetes and Digestive and Kidney Diseases><Necrosis><Necrotic><Necrotizing Enterocolitis><Neonatal><Nitric Oxide><Nitric Oxide Synthase 3><Nitrogen Monoxide><Nitrogen Protoxide><Nutrition><Operative Procedures><Operative Surgical Procedures><Osteoarthritis><Osteoarthrosis><Outcome><Oxygen Deficiency><Patients><Phase><Population><Preclinical data><Premature Infant><Production><Proenzymes><Progenitor Cells><Programmed Cell Death><Property><Quality Control><Recovery><Removal><Research><Research Personnel><Researchers><Role><Runt Disease><S element><Safety><Scientist><Sepsis><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Source><Stress><Sulfur><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><System><Testing><Therapeutic Effect><Tissues><Transgenic Mice><Transplantation><Type III nitric oxide synthase><Tyrosine><Universities><Vasodilatation><Vasodilation><Vasorelaxation><Veterinarians><Volatilization><Zymogens><absorption><balance><balance function><biological signal transduction><biological systems><bowel><career><cell based intervention><cell mediated intervention><cell mediated therapies><cell motility><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><cost><critical limb Ischemia><degenerative joint disease><design><designing><detection method><detection procedure><detection technique><developmental><diabetic foot wound><digestive tract microbiome><endothelial cell derived relaxing factor><enteric microbiome><experiment><experimental research><experimental study><experiments><gastrointestinal microbiome><genome mutation><graft versus host disease><graft vs host disease><graft vs. host disease><gut microbiome><gut-associated microbiome><hypertrophic arthritis><iPS><iPSC><iPSCs><immunogenicity><improved><in vivo><in vivo Model><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><infants born premature><infants born prematurely><infusions><injury to the intestines><innovate><innovation><innovative><intestinal biome><intestinal injury><intestinal microbiome><medical costs><medical expenses><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><minimally invasive><mortality rate><nano-molar><nanomolar><novel><overexpress><overexpression><paracrine><pediatric><pig model><piglet model><polysulfide><porcine model><preclinical findings><preclinical information><premature><premature baby><premature infant human><prematurity><pressure><preterm baby><preterm infant><preterm infant human><progenitor cell based therapy><progenitor cell therapy><progenitor cell treatment><progenitor therapy><progenitor treatment><proliferation capability><proliferation capacity><proliferation potential><proliferative capability><proliferative capacity><proliferative potential><resection><social role><stem and progenitor cell therapy><stem cell based therapy><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><surgery><swine model><systemic inflammation><systemic inflammatory response><therapeutically effective><transplant>
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Saef Izzy

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$230,730
FY 2026

Project Title

Targeting CNS Neuroinflammation in Traumatic Brain Injury by Nasal Anti-CD3

Grant Number:

5K08NS123503-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY / ABSTRACT Traumatic brain injury (TBI) is a major health problem; 2.5 million Americans sustain TBI each year at a cost of 80 billion dollars annually. Few therapies reduce long-term cognitive sequelae of TBI, and there are only limited options for rehabilitation. Brain injury cause...

Research Terms

<Ablation><Acquired brain injury><Acute><Acute Brain Injuries><Adaptive Immune System><After Care><After-Treatment><Aftercare><American><Ammon Horn><Animal Model><Animal Models and Related Studies><Animals><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antibodies><Area><Attenuated><Autoimmune Diseases><B cell growth factor><B-Cell Differentiation Factor-1><B-Cell Growth Factor-1><B-Cell Growth Factor-I><B-Cell Proliferating Factor><B-Cell Stimulating Factor><B-Cell Stimulating Factor-1><B-Cell Stimulation Factor-1><B-Cell Stimulatory Factor-1><BCDF-1><BCGF><BCGF-1><BCSF 1><BSF-1><BSF1><Behavior><Behavioral><Binetrakin><Biochemical><Bioinformatics><Biological><Bone-Derived Transforming Growth Factor><Brain><Brain Injuries><Brain Nervous System><Brain Trauma><C57BL/6 Mouse><CD3><CD3 Antigens><CD3 Complex><CD3 molecule><CSIF><CSIF-10><Cell Body><Cell Communication and Signaling><Cell Locomotion><Cell Migration><Cell Movement><Cell Signaling><Cells><Cellular Migration><Cellular Motility><Cerebral Contusions><Cervical Lymph Node><Cervical lymph node group><Chronic><Chronic Phase><Clinical Treatment Moab><Co-culture><Cocultivation><Coculture><Coculture Techniques><Cognitive><Cornu Ammonis><Cortical Contusions><Cytokine Synthesis Inhibitory Factor><Data><Disease><Disease Progression><Disorder><Disseminated Sclerosis><Encephalon><FOXP3><FOXP3 gene><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Forkhead Box P3><Funding><Goals><Health><Hippocampus><Hortega cell><Hour><Human><IL-10><IL-10 receptor><IL-4><IL10><IL10A><IL4 Protein><Immediate Memory><Immune mediated therapy><Immune response><Immune system><Immunologic Stimulation><Immunological Stimulation><Immunologically Directed Therapy><Immunology><Immunomodulation><Immunostimulation><Immunotherapeutic agent><Immunotherapy><In Vitro><Inflammation><Inflammatory><Inflammatory Response><Injury><Innate Immune Response><Innate Immune System><Interleukin 10 Precursor><Interleukin-10><Interleukin-4><Interleukin-4 Precursor><Intracellular Communication and Signaling><Investigators><Ipsilateral><JM2><Knowledge><Learning><Lesion><Lymphocyte Stimulatory Factor 1><MCGF-2><Mast Cell Growth Factor-2><Mechanics><Mediating><Medical Rehabilitation><Mentors><Mice><Mice Mammals><Microglia><Milk Growth Factor><Modeling><Modern Man><Molecular><Monoclonal Antibodies><Motor><Multiple Sclerosis><Murine><Mus><NIH><Nasal><Nasal Passages Nose><National Institutes of Health><Nature><Neurologic Deficit><Nose><OKT3 antigen><Outcome><Pathogenesis><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phase><Phenotype><Platelet Transforming Growth Factor><Play><RNA Seq><RNA sequencing><RNAseq><Regulation><Regulatory T-Lymphocyte><Rehabilitation><Rehabilitation therapy><Research><Research Personnel><Researchers><Respiratory System, Nose, Nasal Passages><Role><SCURFIN><Short-Term Memory><Signal Transduction><Signal Transduction Systems><Signaling><Survey Instrument><Surveys><T cell response><T-Cell Growth Factor 2><T-Cells><T-Lymphocyte><T3 Antigens><T3 Complex><T3 molecule><TBI recovery><TBI therapy><TBI treatment><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><Tamoxifen><Teff cell><Testing><Therapeutic Effect><Time><Training><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Traumatic Brain Injury><Traumatic Brain Injury recovery><Travel><Treg><United States National Institutes of Health><Upregulation><Work><acquired immune system><adaptive immune response><adaptive immunity><attenuate><attenuates><autoimmune condition><autoimmune disorder><autoimmunity disease><behavior outcome><behavioral outcome><biologic><biological signal transduction><brain cell><brain damage><brain-injured><career><cell motility><clinical applicability><clinical application><cognitive function><controlled cortical impact><cost><cytokine><disability><effective therapy><effective treatment><effector T cell><experience><experiment><experimental research><experimental study><experiments><flow cytophotometry><gitter cell><glial activation><glial cell activation><global gene expression><global transcription profile><hippocampal><host response><immune drugs><immune modulation><immune regulation><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapeutics><immune-based therapies><immune-based treatments><immuno therapy><immunologic reactivity control><immunologic therapeutics><immunomodulatory><immunoneurology><immunoregulation><immunoregulatory><immunoresponse><immunotherapeutics><immunotherapy agent><improved><in vivo><injuries><insight><insular sclerosis><interleukin-10 receptor><mAbs><mechanic><mechanical><mesoglia><microglial cell><microgliocyte><migration><model of animal><monoclonal Abs><mouse model><murine model><neural><neural inflammation><neuroimmunology><neuroinflammation><neuroinflammatory><neurological recovery><neuron toxicity><neuronal toxicity><neuropathologic><neuropathological><neuropathology><neurotoxic><neurotoxicity><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><patient oriented outcomes><perivascular glial cell><post treatment><protective effect><recovery after TBI><recovery after traumatic brain injury><regulatory T-cells><rehab therapy><rehabilitative><rehabilitative therapy><response><social role><thymus derived lymphocyte><transcriptome><transcriptome sequencing><transcriptomic sequencing><traumatic brain damage><traumatic brain injury therapy><traumatic brain injury treatment><working memory>
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Vinitha Jacob

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$213,300
FY 2026

Project Title

The Role of DHCR7 in Endotoxemia

Grant Number:

5K08GM151392-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Sepsis is a common and deadly disease and treatment options are limited to antibiotics and supportive care. Endotoxemia is a key feature of sepsis pathogenesis and can also contribute to numerous other inflammatory disorders. Growing antibiotic resistance and an aging popul...

Research Terms

<7-DHC><7-dehydrocholesterol><7-dehydrocholesterol reductase><7-dehydrocholesterol-delta-7-reductase><AY 9944><AY9944><Acute><Acute Disease><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotics><Award><Blood Vessels><Blood leukocyte><Brachydanio rerio><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Body><Cell Membrane Lipid Rafts><Cell membrane><Cells><Cessation of life><Cholesterol><Cholesterol Homeostasis><Clinical><Collaborations><Complement><Complement Proteins><Cytoplasmic Membrane><DHCR7 enzyme><Danio rerio><Data><Death><Death Rate><Dehydrocholesterols><Dehydrogenases><Development><Disease><Disorder><Doctor of Philosophy><Drug Utilization><Drugs><Emergency Medicine><Endotoxemia><Endotoxins><Enzyme Gene><Enzyme Inhibition><Enzymes><Extravasation><FDA approved><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Fishes><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Genes><Goals><History><Hospital Admission><Hospitalization><Human><Immune><Immune Cell Activation><Immune response><Immunes><In Vitro><Infection><Inflammation><Inflammatory><Inflammatory Response><K-Awards><K-Series Research Career Programs><Knowledge><Leakage><Leukocytes><Leukocytes Reticuloendothelial System><Libraries><Lipids><Lipopolysaccharides><Macrophage><Mammalia><Mammals><Marrow leukocyte><Mediating><Medication><Membrane><Membrane Microdomains><Mentors><Mentorship><Messenger RNA><Mice><Mice Mammals><Michigan><Miscellaneous Antibiotic><Modeling><Modern Man><Murine><Mus><Mφ><NADPH-sterol delta 7-reductase><Organ><Outcome><Oxidoreductase><Oxidoreductase Gene><Pathogenesis><Pathway interactions><Ph.D.><PhD><Pharmaceutical Preparations><Physicians><Plasma Membrane><Platelet aggregation><Publishing><RNA Seq><RNA sequencing><RNAseq><Recording of previous events><Reductases><Research Career Program><Resistance to antibiotics><Resistant to antibiotics><Role><Sampling><Scientist><Sepsis><Sphingolipid Microdomains><Sphingolipid-Cholesterol Rafts><Spillage><Supportive Therapy><Supportive care><System><Techniques><Teratogenic><Teratogenicity><Teratogens><Testing><Toxic effect><Toxicities><Training><Translating><Universities><Viral><White Blood Cells><White Cell><Work><Zebra Danio><Zebra Fish><Zebrafish><acute disease/disorder><acute disorder><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><aging population><antibiotic drug resistance><antibiotic resistant><antisepsis treatment><career><cholesterol metabolism><complementation><compound repositioning><compound repurposing><death due to sepsis><death related to sepsis><developmental><drug candidate><drug discovery><drug repositioning><drug repurposing><drug/agent><enzyme activity><experience><genome editing><genomic editing><histories><host response><immune activation><immune system response><immunoresponse><improved><in vivo><individuals with sepsis><inflammatory modulation><inhibitor><lipid raft><mRNA><membrane structure><mortality><mortality associated with sepsis><mortality in sepsis><mortality rate><mouse model><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic uses for existing drugs><new therapeutics><new therapy><new use of drug><new uses for an approved drug><new uses for existing drugs><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><patients with sepsis><people with sepsis><pharmacological repurposing><plasmalemma><population aging><prevent><preventing><protective effect><repositioning approved drugs><repositioning existing drugs><repurpose approved drugs><repurpose approved medication><repurpose approved therapeutic><repurpose existing drugs><repurpose existing medication><repurpose existing medicine><repurpose existing therapeutics><repurpose existing therapies><repurpose medicine><repurposing><repurposing a drug><repurposing agent><repurposing candidates><repurposing established drugs><repurposing established medication><repurposing existing pharmacological agents><repurposing medication><repurposing of already existing drugs><repurposing pharmaceuticals><sepsis associated death><sepsis associated mortality><sepsis care><sepsis caused deaths><sepsis death><sepsis groups><sepsis induced death><sepsis induced mortality><sepsis interventions><sepsis lethality><sepsis management><sepsis mortality><sepsis patients><sepsis population><sepsis related deaths><sepsis related mortality><sepsis subjects><sepsis therapeutics><sepsis therapy><sepsis treatment><septic death><septic group><septic individuals><septic mortality><septic patients><septic people><septic population><septic subject><septic therapy><septic treatment><social role><subjects with sepsis><therapeutic repositioning><therapeutic repurposing><tool><transcriptome sequencing><transcriptomic sequencing><translational pipeline><translational spectrum><treat sepsis><vascular><white blood cell><white blood corpuscle><zebrafish development>
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Aaron Jay Dawes

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$212,332
FY 2026

Project Title

Optimizing Medicaid Managed Care to Improve Access, Quality, and Clinical Outcomes for Patients with Gastrointestinal Cancers

Grant Number:

1K08CA301027-01A1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2031

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This goal of this K08 is to provide mentorship, training, and applied research opportunities for Dr. Aaron Dawes to help him become an independent investigator with a focus on access and quality of specialty cancer care. In the wake of the Affordable Care Act, millions of Medicaid enrollees with can...

Research Terms

<Access to Care><Address><Affect><Affordable Care Act><American><Applied Research><Applied Science><Applied Skills><Area><Award><California><Cancers><Caring><Clinical><Colon Cancer><Colon Carcinoma><Colon and Rectal Surgeon><Complex><County><Data><Data Set><Department of Health and Human Services><Diagnosis><Disease><Disorder><Enrollment><Equity><Fee-for-Service Plans><Fees for Service><Foundations><Funding><GI cancers><GI malignancies><GI tract cancers><Gastrointestinal Cancer><Gastrointestinal Tract Cancer><Geography><Goals><Guidelines><Health><Health Care Costs><Health Care Utilization><Health Costs><Health Insurance><Health Policy><Health Services><Health Services Accessibility><Improve Access><Individual><Insurance><Intervention><Investigators><Link><Literature><Malignant Gastrointestinal Neoplasm><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of gastrointestinal tract><Managed Care><Managed Care Programs><Managed Health Care Insurance Plans><Measures><Medicaid><Medical Oncologist><Mentorship><Modeling><Natural experiment><Neighborhoods><Obamacare><Operative Procedures><Operative Surgical Procedures><Outcome><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pattern><Policies><Position><Positioning Attribute><Predisposition><Primary Care><Program Sustainabilities><Program Sustainability><Provider><QOC><Quality of Care><Radiation><Radiation Oncologist><Regulation><Reporting><Research><Research Personnel><Researchers><Risk><Role><Services><Socioeconomically disadvantaged><Specialty><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Susceptibility><Techniques><Testing><Training><Translating><Travel><United States Department of Health and Human Services><United States Dept. of Health and Human Services><Universities><Vulnerable Populations><Wait Time><access differences><access to health services><access to services><access to treatment><accessibility to health services><availability of services><cancer care><cancer epidemiology><cancer in the colon><cancer registry><cancer type><care access><care outcomes><care utilization><career><causal diagram><causal model><chemotherapy><design><designing><differences in access><disparity in health><enroll><experience><federal policy><gastrointestinal malignancies><health and care delivery><health care delivery><health care outcomes><health care policy><health care service use><health care service utilization><health delivery systems><health disparity><health equity><health insurance plan><health service access><health services availability><health services delivery><improved><malignancy><managed care insurance><managed care plan><medical specialties><men><neoplasm registry><neoplasm/cancer><novel><pathway><patient oriented outcomes><patient registry><prevent><preventing><professor><program sustainment><programs><provider networks><service availability><sex><skills><social disadvantage><social disparities><social inequality><social role><social vulnerability><socio-economic disadvantage><socio-economically disadvantaged><socio-economically underprivileged><socioeconomic disadvantage><socioeconomically underprivileged><surgery><treatment access><treatment effect><vulnerable group><vulnerable individual><vulnerable people>
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Christopher John Bowman

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$201,744
FY 2026

Project Title

Transcriptional Mechanisms that Catalyze Dysregulated Type 17 Mucosal Inflammation via Innate Lymphoid Cells

Grant Number:

1K08AI196236-01

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Chronic inflammatory diseases, such as inflammatory bowel disease, psoriatic arthritis, and lupus, impose a significant public health burden. Despite our understanding of type 17 immune responses, the mechanisms by which aberrant type 17 inflammation is triggered and sustained remain unclear. Given ...

Research Terms

<Address><Affect><American><Area><Arthritis><Atrophic Arthritis><Autoimmune Diseases><Autoregulation><Basal Transcription Factor><Basal transcription factor genes><Bioinformatics><Biology><Biometrics><Biometry><Biostatistics><Body Tissues><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><California><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Body><Cell Communication and Signaling><Cell Count><Cell Growth and Maintenance><Cell Maintenance><Cell Number><Cell Signaling><Cells><Chromatin><Chronic><Clinical><Clinical Research><Clinical Study><Computational Biology><Control Groups><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><Data><Development><Disease><Disorder><Disseminated Sclerosis><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Equilibrium><Event><Fostering><Foundations><Funding><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Transcription><Health><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Hepatobiliary><Homeostasis><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL-22><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><Immune><Immune response><Immunes><Immunobiology><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunology><Immunomodulation><Immunophysiology><Immunosuppressed Host><Inducer Cells><Inducer T-Lymphocytes><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin-17><Intervention><Intestinal><Intestinal Mucosa><Intestines><Intracellular Communication and Signaling><Joints><K-Awards><K-Series Research Career Programs><KI mice><Kidney><Kidney Urinary System><Knock-in Mouse><Knowledge><Lupus><Lymphatic cell><Lymphocyte><Lymphocytic><Lymphoid><Lymphoid Cell><Maintenance><Maps><Masks><Mediating><Mentors><Mentorship><Mice><Mice Mammals><Modeling><Molecular><Mucosa><Mucosal Inflammation><Mucosal Tissue><Mucositis><Mucous Membrane><Multiple Sclerosis><Murine><Mus><Pathogenicity><Pathology><Pathway interactions><Patients><Phenocopy><Physicians><Physiologic><Physiological><Physiological Homeostasis><Play><Population><Process><Production><Proliferating><Psoriasis Arthropathica><Psoriatic Arthritis><Public Health><RNA Expression><Research><Research Career Program><Research Training><Rheumatoid Arthritis><Role><San Francisco><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Site><Skin><Small Intestines><Specialty><Stimulus><Structure><T-Cells><T-Lymphocyte><Therapeutic><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Universities><arthritic><autoimmune condition><autoimmune disorder><autoimmunity disease><balance><balance function><biological signal transduction><bowel><bowel inflammation><career><cell type><chronic inflammatory disease><computer biology><cytokine><develop therapy><developmental><epigenetically><epigenomics><gastrointestinal><global health><gut inflammation><host response><human disease><immune modulation><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><immunosuppressed patient><improved><in vivo><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><insight><insular sclerosis><interleukin-22><intervention development><intestinal autoinflammation><intestinal inflammation><knockin mice><lymph cell><medical specialties><mouse model><multidisciplinary><murine model><mutant><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><p65><pathway><prevent><preventing><programs><renal><rheumatic arthritis><skills><small bowel><social role><societal costs><therapy development><thymus derived lymphocyte><transcription factor><transcriptomics><transdifferentiation><treatment development>
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Divya A. Chari

MASSACHUSETTS EYE AND EAR INFIRMARY, BOSTON, MA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$194,400
FY 2026

Project Title

The Phex Pathway: Mechanisms Underlying a Meniere's Disease Subtype

Grant Number:

5K08DC022696-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Meniere’s disease (MD), a chronic inner ear disorder characterized by debilitating symptoms of progressive hearing loss and episodic vertigo, arises from unclear etiology. Recent work from our institution identified a distinct subtype of MD – designated MDhp – representing a group o...

Research Terms

<Animal Model><Animal Models and Related Studies><Antibodies><Auditory><Automobile Driving><Autopsy><Autoregulation><Award><Bilateral><Blood Serum><Bone Growth><Causality><Characteristics><Chromosome Mapping><Chronic><Clinical Treatment><Clinical Treatment Moab><Cochlea><Cochlear Organ><Corti Cell><DNA mutation><Data><Degenerative Disorder><Development><Dysfunction><Embryo><Embryonic><Endolymphatic Hydrops><Epithelial Cells><Equilibrium Hair Cell><Etiology><Exhibits><Failure><Familial hypophosphatemic bone disease><Functional disorder><Gene Localization><Gene Mapping><Gene Mapping Genetics><General Radiology><Genes><Genetic Change><Genetic defect><Genetic mutation><Genotype><Goals><Grant><Hair Cells><Hearing Disorders><Hearing Loss><Hearing problem><Hereditary><Histologic><Histologically><Homeostasis><Human><Hypoacuses><Hypoacusis><Hypophosphatemic Rickets><Impairment><Inherited><Inner Ear Disorder><Institution><Internal Ear><Knowledge><Laboratories><Labyrinth><Lead><Link><Linkage Mapping><Meniere's Disease><Meniere's Disorder><Meniere's Syndrome><Mentors><Metabolic Diseases><Metabolic Disorder><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Monoclonal Antibodies><Morphology><Murine><Mus><Mutation><Ménière's disease><Orphan Disease><Pathway interactions><Patients><Pb element><Peripheral><Phenotype><Phosphates><Physiologic><Physiological><Physiological Homeostasis><Physiology><Physiopathology><Play><Production><Radiography><Radiology><Radiology Specialty><Rare Diseases><Rare Disorder><Research><Rickets><Roentgenography><Role><Scientist><Serum><Signal Pathway><Spinning Sensation><Subjective Vertigo><Surgeon><Symptoms><Temporal Bone><Temporal bone structure><Testing><Thesaurismosis><Time><Total Human and Non-Human Gene Mapping><Training><Transcript><VIT D><Vertigo><Vestibular><Vestibular Aqueduct><Vestibular Hair Cells><Vestibular System Impairment><Vestibular defect><Vestibular dysfunction><Vestibular loss><Vestibular problems><Vitamin D><Vitamin D-Resistant Rickets><Wild Type Mouse><Work><X linked hypophosphatemia in rickets><X-Linked Hypophosphatemic Rickets><X-linked hypophosphatemia><auditory disease><auditory disorder><auditory dysfunction><auditory problem><causation><clinical diagnosis><clinical diagnostics><clinical intervention><clinical therapy><cohort><debilitating symptom><degenerative condition><degenerative disease><developmental><diagnostic criteria><disabling symptom><disease causation><disease subgroups><disease subtype><disorder subtype><driving><dysfunctional hearing><ear hair cell><early adulthood><emerging adult><endolymphatic sac><entire genome><familial hypophosphatemia in rickets><full genome><functional loss><functional mimics><genetic mapping><genome mutation><genome sequencing><hearing challenged><hearing defect><hearing deficient><hearing deficit><hearing difficulty><hearing disease><hearing dysfunction><hearing impairment><heavy metal Pb><heavy metal lead><hypophosphatemia in rickets><improved><in utero><in vivo><inner ear><inner ear diseases><inorganic phosphate><labyrinthine hydrops><later in life><later life><loss of function mutation><mAbs><medical diagnostic><metabolism disorder><model of animal><monoclonal Abs><mouse model><murine model><necropsy><neuronal survival><orphan disorder><pathophysiology><pathway><post-natal development><postmortem><postnatal><postnatal development><prevent><preventing><progressive hearing loss><radiological imaging><social role><spatial and temporal><spatial temporal><spatiotemporal><trial regimen><trial treatment><vestibular deficit><vestibular impairment><vestibular system><vestibular system dysfunction><whole genome><wildtype mouse>
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Claire C Conley

GEORGETOWN UNIVERSITY, WASHINGTON, DC

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$194,142
FY 2026

Project Title

The FYI on MRI: A Multilevel Decision Support Intervention for Screening Breast MRI

Grant Number:

5K08CA270402-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/5/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The proposed K08 career development award will provide Dr. Conley with the training and mentorship necessary to become an independent clinical scientist focused on leveraging multilevel approaches to support informed decision making about risk-based cancer screening in diverse popula...

Research Terms

<Address><American Cancer Society><American College of Radiology><Awareness><Behavioral><Biopsy><Black><Black race><Breast><Breast Cancer><Breast Cancer Detection><Breast Cancer Gail Model><Breast Cancer Gail Model Risk Assessment Tool><Breast Cancer Risk Assessment Tool><Breast Cancer Risk Factor><Breast MRI><Breast Magnetic Resonance Imaging><Breast cancer screening><Breast screening><CCOP><Cancer Burden><Cancer Cause><Cancer Etiology><Capital><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Caucasian Females><Caucasian Women><Cessation of life><Clinic><Clinical><Communities><Community Clinical Oncology Program><Community Oncology><Complement><Complement Proteins><Comprehensive Cancer Center><Conflict><Conflict (Psychology)><D.C. Washington><DC Washington><Data><Death><Decision Aid><Decision Making><Development><Diagnosis><Disparities><Disparity><District of Columbia><Early identification><Effectiveness of Interventions><Environment><Epidemiologist><Future><Gail model><Goals><Guidelines><High Risk Woman><Individual><International><Intervention><Interview><K-Awards><K-Series Research Career Programs><Knowledge><Latina><Latina Population><Latina females><Latina women><Latina/e women><Latina/x women><Latinas><Latine females><Latine women><Latino females><Latino women><Latinx females><Latinx women><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Malignant Breast Neoplasm><Mammogram><Mammographic screening><Mammography><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mentors><Mentorship><Modality><NBCCEDP><NCCN><NCMHD><NIMHD><NMR Imaging><NMR Tomography><National Breast and Cervical Cancer Early Detection Program><National Cancer Burden><National Center on Minority Health and Health Disparities><National Comprehensive Cancer Network><National Institute of Minority Health and Health Disparities><National Institute on Minority Health and Health Disparities><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Nuclear Magnetic Resonance Imaging><Nurse Practitioners><Oncologist><Participant><Patient Preferences><Patient-Centered Care><Patients><Persons><Population><Population Heterogeneity><Position><Positioning Attribute><Protocol><Protocols documentation><Race><Races><Randomization trial><Randomized><Recommendation><Research><Research Career Program><Research Support><Risk><Risk Assessment><Scientist><Screening for cancer><Site><System><Testing><Training><Training Programs><Translating><U.S. Preventative Services Task Force><U.S. Preventative Task Force><U.S. Preventive Services Task Force><U.S. Preventive Task Force><US Preventative Services Task Force><US Preventative Task Force><US Preventive Health Services Task Force><US Preventive Services Task Force><US Preventive Task Force><USPSTF><United States Preventative Services Task Force><United States Preventative Task Force><United States Preventive Services Task Force><United States Preventive Task Force><White Females><White Women><Woman><Women's Health Check Program><Work><Zeugmatography><at-risk females><at-risk women><black female><black women><breast cancer risk><cancer diagnosis><cancer risk><care as usual><career><community advisory board><community advisory committee><community advisory panel><community engaged participatory research><community engaged research><community partnered research><community setting><community-engaged study><community-partnered study><complementation><cost><cultural values><developmental><diverse populations><early cancer detection><effectiveness testing><experience><females at high risk><heterogeneous population><high risk><high risk females><intervention effect><life-time risk><lifetime risk><malignant breast tumor><mammary cancer detection><mammary screening><mammographic Imaging><mammographic examinations><mammographic exams><mammography screening><patient level intervention><patient navigation><patient navigator><population diversity><post intervention><preference><prevent><preventing><primary outcome><programs><racial><racial background><racial origin><randomisation><randomization><randomized trial><randomly assigned><recommended screening><risk prediction algorithm><risk prediction model><satisfaction><screening><screening cancer patients><screening guidelines><screening recommendations><screenings><secondary outcome><skills><treatment as usual><usual care><women at high risk><younger age>
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Kelly Michaelsen

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$186,724
FY 2026

Project Title

Intelligent wearable system for preventing medication errors in anesthesiology

Grant Number:

5K08GM153069-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2024

End Date:

4/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Adverse events associated with injectable medications are estimated to impact millions of hospitalizations annually with billions of dollars in associated costs and thousands of deaths. Drug administration errors are the most frequently reported critical incidents in anesthe...

Research Terms

<Accidents><Adverse Experience><Adverse event><Algorithms><Anesthesia><Anesthesia procedures><Anesthesiology><Anesthestic Drugs><Anesthetic Agents><Anesthetic Drugs><Anesthetics><Augmented Reality><Award><Bar Codes><Causality><Cessation of life><Classification><Clinical><Computer Vision Systems><Computer software><Computerized Medical Record><Computers><Consumption><Data Bases><Data Set><Databases><Death><Devices><Dose><Drug Compounding><Drug Delivery><Drug Delivery Systems><Drug Preparation><Drugs><Electronic Health Record><Electronic Medical Record><Elements><Emergencies><Emergency Situation><Engineering><Environment><Etiology><Event><Eye><Eyeball><Feedback><Future><Grant><Hand><Handwashing><Head><Health><Hospital Admission><Hospitalization><Hospitals><Human><Image><Injectable><Injections><Institution><Intensive Care Units><Label><Learning Skill><Light><Machine Learning><Manuals><Measures><Medical Errors><Medical Mistakes><Medical Records><Medication><Medication Errors><Methodology><Modality><Modern Man><Monitor><Operating Rooms><Operative Procedures><Operative Surgical Procedures><Patients><Performance><Persons><Pharmaceutical Preparations><Photoradiation><Procedures><Provider><Public Health><Records><Reporting><Resolution><Risk><Safety><Scanning><Software><Standardization><Sterility><Surgical><Surgical Interventions><Surgical Procedure><Syringes><System><Systematics><Techniques><Technology><Time><Training><United States><Vial><Vial device><Video Recording><Videorecording><Weight><Work><Work Load><Workload><adherence by clinicians><adherence by providers><auditory feedback><barcode><causation><clinician adherence><clinician compliance><computer vision><cost><data base><design><designing><detection platform><detection system><direct patient care><disease causation><dosage><drug/agent><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><experience><feasibility testing><hand washing><hands><imaging><improved><innovate><innovation><innovative><light weight><lightweight><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><medication administration errors><neural network><patient safety><physician adherence><physician compliance><prevent><preventing><prototype><provider adherence><provider compliance><resolutions><risk mitigation><sterile><surgery><tool><video recording system><virtual><visual feedback><wearable><wearable device><wearable electronics><wearable system><wearable technology><wearable tool><wearables><weights>
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Regina M Myers

CHILDREN'S HOSP OF PHILADELPHIA, PHILADELPHIA, PA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$181,074
FY 2026

Project Title

Optimizing outcomes for children and young adults with relapse of B-cell acute lymphoblastic leukemia after CD19-targeted chimeric antigen receptor T-cell therapy

Grant Number:

5K08CA277013-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT This K08 Award encompasses a research and training plan to facilitate Dr. Regina Myers' transition to an independent clinical investigator. Dr. Myers is currently an Instructor of Pediatrics and a pediatric oncology and cell therapy physician at Children's Hospital of Philad...

Research Terms

<0-11 years old><21+ years old><Acute B-Lymphocytic Leukemia><Adult><Adult Human><Antigen Targeting><Award><B Cell Antigen CD19><B cell progenitor acute lymphoblastic leukemia><B-ALL><B-Cell Acute Lymphocytic Leukemia><B-Cell Acute Lymphoblastic Leukemia><B-Cell Lymphoblastic Leukemia><B-Lymphocyte Antigen CD19><B-Lymphocyte Surface Antigen B4><B-cell ALL><B-cell precursor acute lymphoblastic leukemia><Biological Markers><CAR T cell therapy><CAR T cells><CAR T therapy><CAR modified T cells><CAR-T><CAR-Ts><CD19><CD19 Antigens><CD19 gene><CD19 molecule><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Therapy><Child><Child Youth><Childhood><Childhood Cancers><Children (0-21)><Children's Hospital><Clinical Investigator><Clinical Research><Clinical Study><Clinical Trials><Clinical Trials Design><Cytotoxic agent><Cytotoxic drug><Data><Detectable Residual Disease><Differentiation Antigen CD19><Disease remission><Disease-Free Survival><Enrollment><Environment><Epidemiologic Methodology><Epidemiologic Methods><Epidemiologic Research><Epidemiologic research methodology><Epidemiologic research methods><Epidemiological Methods><Epidemiological Techniques><Event-Free Survival><Experimental Therapies><Failure><Foundations><Frequencies><Goals><HSC transplantation><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Immune><Immune mediated therapy><Immunes><Immunologically Directed Therapy><Immunotherapy><Infrastructure><Instruction><International><Investigational Therapies><Investigational Treatments><K-Awards><K-Series Research Career Programs><Lead><Leu 12><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Hematologic Neoplasm><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant childhood cancer><Mediating><Mentorship><Methods><Methods Epidemiology><Methods in epidemiology><Mice><Mice Mammals><Minimal Residual Disease><Murine><Mus><NGS Method><NGS system><Outcome><Outcomes Research><Patients><Pb element><Pediatric Hospitals><Pediatric Oncology><Pediatrics><Pennsylvania><Phase><Phase 1/2 Clinical Trial><Phase I Study><Phase I/II Clinical Trial><Philadelphia><Physicians><Pre-B-Cell Leukemia><Precursor B Lymphoblastic Leukemia><Predictive Value><Process Assessment><Prognosis><Proxy><Recommendation><Refractory><Relapse><Remission><Research><Research Career Program><Research Infrastructure><Research Resources><Residual Neoplasm><Residual Tumors><Resources><Safety><Scientist><T cells for CAR><Testing><Therapeutic><Time><Toxic effect><Toxicities><Training><Transplant Recipients><Universities><Variant><Variation><adult youth><adulthood><anti-cancer immunotherapy><anticancer immunotherapy><arm><bio-markers><biologic marker><biomarker><blood stem cell transplantation><cancer clinical trial><cancer immunotherapy><cancer in a child><cancer in children><career><cell based intervention><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><chemotherapy><child with cancer><childhood malignancy><chimeric antigen T cell receptor><chimeric antigen receptor (CAR) T cell therapy><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cell therapy><chimeric antigen receptor T cells><chimeric antigen receptor T therapy><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><clinical epidemiology><cohort><comparative effectiveness><comparative effectiveness study><compare effectiveness><conventional therapy><conventional treatment><data collected in real world><data pipeline><data resource><design><designing><early clinical trial><early phase clinical trial><effective therapy><effective treatment><efficacy outcomes><enroll><epidemiologic investigation><epidemiology research study><epidemiology study><epidemiology survey><evidence base><experience><experimental therapeutic agents><experimental therapeutics><heavy metal Pb><heavy metal lead><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><high risk><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based cancer therapies><immune-based therapies><immune-based treatments><immuno therapy><immunotherapy clinical trials><immunotherapy for cancer><immunotherapy of cancer><improved><improved outcome><innovate><innovation><innovative><instructor><investigate epidemiology><kids><leukemia><multidisciplinary><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next gen sequencing><next generation><next generation sequencing><next generation therapeutics><nextgen sequencing><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><oncology clinical trial><patient prognosis><pediatric><pediatric cancer><pediatric malignancy><phase 1 study><phase 1 trial><phase I trial><programs><randomized, clinical trials><real world data><residual disease><response><safety outcomes><secondary analysis><specific biomarkers><study epidemiology><survey epidemiology><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transplant patient><treatment strategy><young adult><young adult age><young adulthood><youngster>
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JOHN R DICKSON

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$172,800
FY 2026

Project Title

The Influence of Tau Post-Translational Modifications on the Propagation of Tau Pathology in Alzheimer's Disease

Grant Number:

5K08AG078341-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/4/2022

End Date:

4/30/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Narrative This K08 Mentored Clinical Scientist Research Career Development Award application investigates the role of tau post-translational modifications on the cellular processes involved in the stereotyped spreading of tau pathology that occurs as Alzheimer’s disease progresses. ...

Research Terms

<3-D><3-Dimensional><3D><AD brain><AD dementia><AD patients><Acetylation><Address><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's brain><Alzheimer's disease brain><Alzheimer's disease patient><Alzheimer's patient><Alzheimers Dementia><Amentia><Amino Acids><Assay><Bioassay><Biological Assay><Biology><Biosensor><Brain region><CBP-30><CBP-35><CBP35><Carbohydrate-Binding Protein 35><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Body><Cell Culture Techniques><Cell Function><Cell Physiology><Cell Process><Cell model><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular model><Charge><Chemicals><Clinical><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communication><Cytoplasm><DNA mutation><Data><Deacetylation><Dementia><Dephosphorylation><Development><Development Plans><Disease><Disorder><Disturbance in cognition><Dysfunction><Endosomes><Epsilon-Binding Protein><Evaluation><FRET><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Fluorescence Resonance Energy Transfer><Functional disorder><Förster Resonance Energy Transfer><Galectin 3><General Radiology><Genetic Change><Genetic defect><Genetic mutation><Grant><HL-29><IgE Binding Protein><IgEBP><Impaired cognition><In Vitro><Induced pluripotent stem cell derived human neuron><K-Awards><K-Series Research Career Programs><L-29 Lectin><L-31><L-34><L30 Lectin><LGALS3><Literature><Luciferase Immunologic><Luciferases><MT-bound tau><Mac-2 Antigen><Macrophage-2 Antigen><Manuscripts><Mentors><Mentorship><Modeling><Modification><Molecular><Molecular Weight><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurocyte><Neurofibrillary Tangles><Neurons><PET><PET Scan><PET imaging><PETSCAN><PETT><Pathologic><Pattern><Performance><Phosphorylation><Physicians><Physiopathology><Play><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Preparation><Primary Senile Degenerative Dementia><Process><Property><Protein Dephosphorylation><Protein Modification><Protein Phosphorylation><Publishing><Rad.-PET><Radiology><Radiology Specialty><Receptosomes><Recombinants><Research><Research Career Program><Role><Scientist><Staining method><Stains><Stereotyping><Subcellular Process><Tau forming aggregates><Tauopathies><Techniques><Testing><Writing><aberrant tau><aberrant tau protein><abeta accumulation><abeta aggregation><abnormal tau><abnormal tau protein><abnormally aggregated tau protein><aggregation in tau><aminoacid><amyloid beta accumulation><amyloid beta aggregation><amyloid β accumulation><amyloid β aggregation><aβ accumulation><aβ aggregation><biological sensor><brain cell><career><career development><cell culture><cell cultures><cognitive dysfunction><cognitive loss><defined contribution><design><designing><developmental><endosome membrane><experience><experiment><experimental analysis><experimental research><experimental study><experiments><extracellular><filamentous tau inclusion><flow cytophotometry><genome mutation><hiPSC-derived neurons><human iPSC-derived sensory neuron><human induced pluripotent stem cell derived sensory neuron><iPSC-derived human neuron><immunocytochemistry><inducible pluripotent stem cell derived human neuron><inducible pluripotent stem cell derived human sensory neuron><innovate><innovation><innovative><insight><machine learned algorithm><machine learning algorithm><machine learning based algorithm><meeting><meetings><microtubule associated protein tau aggregation><microtubule associated protein tau deposit><microtubule associated protein tau mutation><microtubule bound tau><microtubule-associated protein tau mutation><microtubule-bound tau><mutant><mutant tau><mutant tau protein><mutation in microtubule associated protein tau><mutation in microtubule-associated protein tau><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neuronal><neuronal circuit><neuronal circuitry><neurons differentiated from human induced pluripotent stem cells><neuropathologic><neuropathologic tau><neuropathological><neuropathological tau><neuropathology><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><p-tau><p-τ><paired helical filament of tau><pathogenic tau><pathogenic tau gene mutation><pathogenic tau protein><pathological change in tau><pathological tau><pathological tau protein><pathophysiology><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><phospho-tau><phospho-τ><phosphorylated tau><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><post-translational modification of tau><posttranslational modification of tau><preparations><primary degenerative dementia><protein structure prediction><self-aggregate tau><senile dementia of the Alzheimer type><skills><social role><tangle><tau><tau PHF><tau Proteins><tau abnormality><tau accumulation><tau aggregate><tau aggregation><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau fibrillation><tau fibrillization><tau filament><tau inclusion><tau induced degeneration><tau induced neurodegeneration><tau intronic mutation><tau mediated neurodegeneration><tau mutation><tau neurodegenerative disease><tau neurofibrillary tangle><tau neuropathology><tau oligomer><tau paired helical filament><tau pathological change><tau pathology><tau pathophysiology><tau phosphorylation><tau polymerization><tau posttranslational modification><tau protein accumulation><tau protein aggregation><tau proteinopathy><tau related neurodegeneration><tau-1><tau-induced pathology><tau-tau interaction><tauopathic neurodegenerative disorder><tauopathy><three dimensional><τ Proteins><τ aggregation><τ mutation><τ phosphorylation>
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Sarah Kern Whitley

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$168,458
FY 2026

Project Title

Targeting cutaneous nociceptors to reduce Type-17 inflammation in hidradenitis suppurativa

Grant Number:

5K08AR080844-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2024

End Date:

4/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This application, Targeting cutaneous nociceptors to reduce Type-17 inflammation in Hidradenitis Suppurativa, is submitted by me, Sarah Whitley, MD, PhD, in the University of Pittsburgh Department of Dermatology for a Mentored Clinician Scientist Career Development Award (K08). I have a strong backg...

Research Terms

<(TNF)-α><Abscess><Accessory Sinuses><Affect><Anatomic Sites><Anatomic structures><Anatomy><Apocrine Glands><Area><Armpit><Award><Axilla><Axillary><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><BTX - based therapies><BTX treatment><Biological Agent><Biological Products><Biology><BoNT therapy><BoNT treatment><Body Tissues><Bontoxilysin><Botulin><Botulinum Toxins><C albicans><C. albicans><C.albicans><CCL2><CCL2 gene><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Cachectin><Candida albicans><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Body><Cell Communication and Signaling><Cell Density><Cell Signaling><Cells><Characteristics><Chemokine, CC Motif, Ligand 2><Cicatrix><Clinical><Clinical Trials><Clostridium botulinum Toxins><Computational Biology><Cutaneous><Cutaneous Disorder><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><Data><Dendritic Cells><Dermatology><Dermatoses><Development><Disease><Disease remission><Disorder><Disproportionate number of females><Disproportionate number of women><Disproportionately affects females><Disproportionately affects women><Disproportionately impacts females><Disproportionately impacts women><Disproportionately in females><Disproportionately in women><Doctor of Philosophy><Dose><Environment><Euler-Gaddum Substance P><Extracellular Signal-Regulated Kinase Gene><FDA approved><Fistula><Genomics><HPGF><Hair Follicle><Hair follicle structure><Health><Health Care><Health Care Costs><Health Costs><Hepatocyte-Stimulating Factor><Hidradenitis Suppurativa><Human><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-1><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL-23><IL-6><IL1><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><IL6 Protein><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune infiltrates><Immune response><Immunes><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Immunology><In Vitro><Infection><Inflammation><Inflammatory><Innate Immune System><Institution><Interferon Type I><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin I><Interleukin-1><Interleukin-17><Interleukin-6><Intracellular Communication and Signaling><K-Awards><K-Series Research Career Programs><Lesion><Ligands><Link><Lymphocyte-Stimulating Hormone><MAP Kinase Gene><MAPK><MCAF><MCP-1><MCP1><MGI-2><Macrophage><Macrophage Cell Factor><Macrophage-Derived TNF><Marrow Mast Cell><Measures><Mediating><Memory><Mental Depression><Mentors><Messenger RNA><Methods><Microbe><Minority><Mitogen-Activated Protein Kinase Gene><Modern Man><Monocyte Chemoattractant Protein-1><Monocyte Chemotactic Protein-1><Monocyte Chemotactic and Activating Factor><Monocyte Chemotactic and Activating Protein><Monocyte Chemotactive and Activating Factor><Monocyte Secretory Protein JE><Monocyte-Derived TNF><Myeloid Differentiation-Inducing Protein><Mφ><NGS Method><NGS system><NK-1 Receptors><NK1R><NKIR><Nasal Sinuses><Nasal cavity/Paranasal><Nasal cavity/Paranasal sinuses><Nerve><Neurobiology><Neurogenic Inflammation><Neurokinin-1 Receptors><Neuropeptide Receptor><Neuropeptides><Nociceptors><Pain><Painful><Paranasal Sinuses><Pathogenesis><Pathologic><Patient Care><Patient Care Delivery><Patients><Ph.D.><PhD><Plasmacytoma Growth Factor><Population><Production><Proteins><QOL><QOL improvement><Quality of life><Randomized, Controlled Trials><Receptor Signaling><Remission><Research><Research Career Program><SCYA2><SP-P Receptors><Scars><Scientist><Sensory><Signal Transduction><Signal Transduction Systems><Signaling><Sinus><Skin><Skin Diseases><Skin Diseases and Manifestations><Small Inducible Cytokine A2><Stimulus><Substance P><Substance P Receptor><Suppurative Hidradenitis><T Helper Factor><T cell response><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><TAC1R><TACR1><TACR1 gene><TIL4><TLR protein><TLR2><TLR2 gene><TLR2 receptor><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><TRPV1><TRPV1 gene><Tachykinin Receptor 1><Technology><Testing><Tissue Basophils><Tissues><Toll-Like Receptor 2><Toll-Like Receptor Family Gene><Toll-like receptors><Toll/Interleukin 1 Receptor-Like 4><Toll/Interleukin 1 Receptor-Like 4 Gene><Toll/Interleukin 1 Receptor-Like Protein 4><Training><Translational Research><Translational Science><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Underarm><Universities><Veiled Cells><Work><antagonism><antagonist><anti-microbial><antimicrobial><biological signal transduction><biologics><biopharmaceutical><biotherapeutic agent><botulinum neurotoxin><botulinum neurotoxin based therapeutic><botulinum neurotoxin therapy><botulinum neurotoxin treatment><botulinum toxin therapy><botulinum toxin treatment><care for patients><care of patients><career><caring for patients><chronic inflammatory disease><clinical care><computer biology><cutaneous disease><cutaneous microbiota><cutaneous sensory nerve><cytokine><depression><dermal disease><dermal disorder><dermal microbiota><dermal sensory nerve><determine efficacy><developmental><disease control><disorder control><dysbacteriosis><dysbiosis><dysbiotic><economic impact><effective therapy><effective treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><expectation><experience><experiment><experimental research><experimental study><experiments><female bias><female predominance><female preponderance><functional outcomes><host response><immune cell infiltrate><immune system response><immunoresponse><improved><improvements in QOL><improvements in quality of life><in vitro Assay><inhibitor><innate immune mechanisms><innovate><innovation><innovative><interferon beta 2><interleukin-23><lipo-teichoic acid><lipoteichoic acid><lymphocyte activating factor><mRNA><mast cell><mastocyte><microbial colonization><microbial imbalance><microbial products><neurobiological><neurokinin 1><neurotransmitter antagonist><neurotransmitter inhibitor><next gen sequencing><next generation sequencing><nextgen sequencing><nociceptive neurons><novel><pain relief><pain signal><pain-sensing neurons><pain-sensing sensory neurons><pain-sensing somatosensory neurons><predominance in females><predominance in women><protein expression><quality of life improvement><randomized control trial><randomized controlled design><receptor expression><relieve pain><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skin disorder><skin flora><skin microbial community><skin microbiota><skin microflora><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><targeted agent><thymus derived lymphocyte><transcriptomics><transient receptor potential cation channel V1><translation research><translational investigation><women's predominance><women's preponderance>
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Joshua Curry

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$167,400
FY 2026

Project Title

Kir4.1-dependent mechanisms of potassium sensing and signaling in the thick ascending limb

Grant Number:

1K08DK147727-01

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT ABSTRACT The thick ascending limb (TAL) of the nephron plays a central role in sodium and potassium homeostasis, but its ability to adapt to dietary potassium stress remains poorly defined. Preliminary data indicate that the inwardly rectifying potassium channel Kir4.1 is selectively expres...

Research Terms

<3-D><3-Dimensional><3D><Alkalosis><Alpha Cell><Amiloride><Animal Feed><Apical><Apoptosis><Apoptosis Pathway><Autoregulation><Award><BUdR><Barter's Disease><Bartter Disease><Bartter Syndrome><Bartter syndrome (BS)><Beta Cell><Blood Chemical Analyses><Blood Chemical Analysis><Blood Pressure><Blood Pressure Monitors><BrdU><Bromodeoxyuridine><Bromouracil Deoxyriboside><Broxuridine><Caring><Cell Body><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Cells><Chronic><Co-Transporters><Compensation><Continuous Sphygmomanometers><DNA Nucleotidylexotransferase><Data><Deoxynucleotidyl Transferase><Deoxynucleotidyltransferase><Dependence><Desoxynucleotidyl Transferase><Desoxynucleotidyltransferase><Development><Diet><Dietary K><Dietary Potassium><Disease><Disorder><Distal><Distal Convoluted Tubule><Distal Kidney Tubules><Distal convoluted renal tubule structure><Diuretics><Dysfunction><Electrolyte Disorder><Electrolytes><Electrophysiology><Electrophysiology (science)><Environment><Equilibrium><Excretory function><Exhibits><Extremities><Fluid Balance><Fluid Homeostasis><Fostering><Frusemid><Functional disorder><Furosemide><Fursemide><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Transcription><Genetic><Genetic Models><Genetic Transcription><Glucagon Cell><Glucagon Secreting Cell><Goals><Health><Hereditary><Homeostasis><Hypertension><Hypertrophy><Hypokalemia><Hypopotassemia><IRK1 channel><Image><Immunofluorescence><Immunofluorescence Immunologic><Impairment><In Situ><In Vitro><Inherited><Institution><Insulin Cell><Insulin Secreting Cell><Intake><Intracellular Communication and Signaling><Inward Rectifier K+ Channels><Inwardly Rectifying K+ Channels><Inwardly Rectifying Postassium Channels><Inwardly Rectifying Potassium Channels><K channel><K element><KCNJ1 gene><KO mice><Kidney><Kidney Diseases><Kidney Urinary System><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Knowledge><Label><Lead><Learning><Limb structure><Limbs><Lineage Tracing><LoxP-flanked allele><Measurement><Measures><Mediating><Mentors><Mentorship><Metabolic><Mice><Mice Mammals><Microscopy><Modeling><Modification><Murine><Mus><Na element><Nephrons><Nephropathy><Neurophysiology / Electrophysiology><Non-Trunk><Nucleus><Null Mouse><Occluding Junctions><Oregon><Pathway interactions><Patients><Pb element><Perfusion><Persons><Phenotype><Physicians><Physiological Homeostasis><Physiology><Physiopathology><Play><Population><Potassium><Potassium Channel><Potassium Deficiency><Potassium Ion Channels><Programmed Cell Death><Proliferating><Proteins><RNA Expression><ROMK><Regulation><Renal Cell><Renal Disease><Reporter><Research><Resistance><Role><Science><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Sodium><Stress><Structure><Suspension substance><Suspensions><Syndrome><Terminal Addition Enzyme><Terminal Deoxynucleotidyl Transferase><Terminal Deoxynucleotidyltransferase><Terminal Deoxyribonucleotidyl Transferase><Terminal Deoxyribonucleotidyltransferase><Testing><Thick><Thickness><Tight Junctions><Training><Transcript><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Universities><Uriniferous Tube><Validation><Variant><Variation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Weight><Work><Zonula Occludens><absorption><aldosteronism-normal blood pressure syndrome><alpha-cell><analyze gene expression><animal food><balance><balance function><basolateral membrane><biological signal transduction><blood chemistry><cardiac function><career development><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular lineage mapping><cellular lineage tracking><developmental><dietary restriction><diets><electrophysiological><excretion><experiment><experimental research><experimental study><experiments><extracellular><floxed><floxed allele><function of the heart><gene expression analysis><gene expression assay><heart function><heavy metal Pb><heavy metal lead><high blood pressure><high resolution imaging><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><imaging><improved><induced Cre><inducible Cre><innovate><innovation><innovative><intercalation><inward rectifier potassium channel><juxtaglomerular hyperplasia syndrome><kidney cell><kidney disorder><loss of function mutation><metabolic phenotype><metabotype><morphometry><mouse model><murine model><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><pathophysiology><pathway><programs><renal><renal disorder><renal epithelium><renal outer medullary potassium channel><resistant><response><restricted diet><sNuc-Seq><selective expression><selectively expressed><sensor><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><symporter><thiazide><three dimensional><transcriptional profiling><transcriptomics><validations><weights><α-cell><β-cell><β-cells><βCell>
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Da Zhang

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$166,619
FY 2026

Project Title

Multi-omic profiling of IPF endotypes

Grant Number:

5K08HL169926-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT This K08 Mentored Career Development Award will provide Dr. Da (David) Zhang with structured mentorship and training towards a goal of developing an independent translational research program to study the genetics of idiopathic pulmonary fibrosis (IPF). IPF is a lethal condi...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><ATAC sequencing><ATAC-seq><ATACseq><Active Follow-up><Affect><Aged 65 and Over><Assay for Transposase-Accessible Chromatin using sequencing><Basal Transcription Factor><Basal transcription factor genes><Body Tissues><Candidate Disease Gene><Candidate Gene><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Categories><Cell Body><Cell Nucleus><Cells><Characteristics><Cicatrix><Clinical><Coupled><Cryofixation><Cryopreservation><DNA mutation><Data><Data Set><Diagnosis><Disease><Disease Pathway><Disorder><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Fibrosing Alveolitis><Funding><Future><GTEx><GWA study><GWAS><Gene Expression><Gene variant><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Change><Genetic Risk><Genetic defect><Genetic mutation><Genetic predisposing factor><Genetic study><Genomics><Genotype-Tissue Expression Project><Goals><Heritability><Human Genetics><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Individual><Investigators><K-Awards><K-Series Research Career Programs><Knowledge><Length><Lung><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Lung Tissue Fibrosis><Maps><Mentors><Mentorship><Meta-Analysis><Methods><Multiomic Data><Mutation><NHLBI><NIGMS><National Heart, Lung, and Blood Institute><National Institute of General Medical Sciences><Nuclear RNA><Nucleus><Orphan Disease><Outcome><Pathogenesis><Pathway interactions><Patients><Precision therapeutics><Prevention><Prognosis><Publications><Pulmonary Fibrosis><RNA Seq><RNA sequencing><RNAseq><Rare Diseases><Rare Disorder><Regulatory Element><Research><Research Career Program><Research Personnel><Research Training><Researchers><Risk><Risk Factors><Risk-associated variant><Scars><Scientific Publication><Seminal><Structure><Structure of parenchyma of lung><TOPMed><Testing><Tissue Donors><Tissues><Training><Training Activity><Trans-Omics for Precision Medicine><Transcription Factor Proto-Oncogene><Transcription factor genes><Translational Research Enterprise><Validation><Variant><Variation><Work><above age 65><active followup><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><allelic variant><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><biobank><biorepository><career><career development><cell type><clinical care><clinical relevance><clinically relevant><cohort><cold preservation><cold storage><diffuse interstitial pulmonary fibrosis><entire genome><epigenetically><epigenomics><fibrosis in the lung><follow up><follow-up><followed up><followup><full genome><functional genomics><genetic association><genetic risk factor><genetic variant><genome mutation><genome sequencing><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic variant><human old age (65+)><idiopathic pulmonary fibrosis><immune suppression><immune suppressive activity><immune suppressive function><immunosuppressive activity><immunosuppressive function><immunosuppressive response><inherited factor><innovate><innovation><innovative><low-frequency mutation><lung fibrosis><molecular sequence database><mortality><multidisciplinary><multiomics><multiple omic data><multiple omics><novel><older adult><older adulthood><orphan disorder><over 65 years><panomics><pathway><phenome><precision therapies><precision treatment><programs><prospective><pulmonary><rare allele><rare mutation><rare variant><research data dissemination><research dissemination><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sequence database><sequencing database><skills><telomere><telomere damage><telomeric damage><training module><transcription factor><transcriptome sequencing><transcriptomic sequencing><transcriptomics><translation research enterprise><translational research program><translational study><validations><whole genome><whole genome association analysis><whole genome association study><≥65 years>
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Kale S Bongers

UNIVERSITY OF IOWA, IOWA CITY, IA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$166,428
FY 2026

Project Title

The Role of the Gut Microbiome in Post-Sepsis Skeletal Muscle Atrophy

Grant Number:

5K08AR083015-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY This K08 proposal outlines the plan for Kale Bongers, M.D. Ph.D.’s to complete training toward his long-term goal of improving our understanding of post-sepsis muscle atrophy and weakness through investigation of the microbiome. Dr. Bongers is a physician-scientist in Pulmonary and C...

Research Terms

<Affect><Anabolism><Animal Model><Animal Models and Related Studies><Antibiotic Agents><Antibiotic Drugs><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Atrophic><Atrophy><Award><Bacteria><Biology><Bionomics><Blood><Blood Reticuloendothelial System><Body Tissues><Calibration><Cessation of life><Complement><Complement Proteins><Critical Care><Critical Illness><Critically Ill><Data><Death><Debility><Development><Development Plans><Doctor of Medicine><Doctor of Pharmacy><Doctor of Philosophy><Drug Therapy><Dysfunction><Early Intervention><Ecology><Financial cost><Five-Year Plans><Foundations><Functional Metagenomics><Functional disorder><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Expression><Germ-Free><Goals><Health><Hospital Admission><Hospitalization><Human><Hypertrophy><Immune><Immunes><In Vitro><Infection><Intestinal><Intestines><Investigation><Investigators><Kale><Kale - dietary><Left><Lower GI Tract><Lower Gastrointestinal Tract><M.D.><Measures><Mediating><Mediator><Medical><Medicine><Mentors><Mentorship><Metabolic><Metabolic Pathway><Metagenomics><Mice><Mice Mammals><Michigan><Microbiomics><Miscellaneous Antibiotic><Modern Man><Morbidity><Murine><Mus><Muscle><Muscle Atrophy><Muscle Fibers><Muscle Tissue><Muscle Weakness><Muscular Atrophy><Muscular Weakness><Myotubes><Obesity><Organ><Outcome><Output><Pathogenesis><Patients><Ph.D.><PhD><Pharm.D.><PharmD><Pharmacological Treatment><Pharmacotherapy><Physical Rehabilitation><Physicians><Physiopathology><Play><Productivity><Publishing><QOL><Quality of life><Regulation><Research><Research Personnel><Researchers><Rhabdomyocyte><Risk><Role><Scientist><Secondary to><Sepsis><Severities><Short-Chain Fatty Acids><Skeletal Fiber><Skeletal Muscle><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Supplementation><Survivors><Swab><Techniques><Testing><Therapeutic><Tissues><Training><Translating><United States><Universities><Variant><Variation><Volatile Fatty Acids><Voluntary Muscle><Work><adiposity><after sepsis><after septic><antisepsis treatment><bacteria in the gut><bacterial disease treatment><bacterial infectious disease treatment><biosynthesis><bowel><career development><complementation><corpulence><developmental><digestive tract microbiome><drug intervention><drug treatment><endurance exercise><enteric microbial community><enteric microbiome><enteric microbiota><exercise capacity><experience><experiment><experimental research><experimental study><experiments><following sepsis><following septic><gastrointestinal microbial flora><gastrointestinal microbiome><gut bacteria><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><improved><in vitro Model><in vivo><in vivo Model><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><metabolism measurement><metabolomics><metabonomics><microbial><microbiome><microbiome research><microbiome science><microbiome studies><model of animal><monetary cost><mortality><mouse model><murine model><muscle breakdown><muscle bulk><muscle degradation><muscle deterioration><muscle form><muscle loss><muscle mass><muscle metabolism><muscle physiology><muscle wasting><muscular><pathophysiology><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><physical rehab><post sepsis><post septic><post-doctoral training><prevent><preventing><pulmonary><response><sepsis care><sepsis interventions><sepsis management><sepsis survivor><sepsis survivorship><sepsis therapeutics><sepsis therapy><sepsis treatment><septic survival><septic survivor><septic therapy><septic treatment><skeletal muscle atrophy><skeletal muscle breakdown><skeletal muscle loss><skeletal muscle protein loss><skeletal muscle wasting><skill acquisition><skill development><skills><social role><success><survive sepsis><treat sepsis>
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Ginny Ching-Yun Hsu

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$166,058
FY 2026

Project Title

TIAM1 dictates lineage commitment in skeletal and soft tissue pericytes

Grant Number:

5K08DE031347-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/6/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Bone tissue has high intrinsic regenerative potential, yet deficits in mesenchymal precursor numbers, function, or supportive tissues lead to non-healing bony defects – a significant clinical problem within and outside of the dental sciences. Mixed stromal populations termed...

Research Terms

<Adipocytes><Adipose Cell><Adipose tissue><Adventitial Cell><Anabolism><Anatomic Sites><Anatomic structures><Anatomy><Animals><Area><Arthritis><Assay><Award><Bioassay><Bioinformatics><Biological Assay><Biology><Biometrics><Biometry><Biostatistics><Blood Vessels><Body Tissues><Bone Regeneration><Bone Tissue><CD146><CD146 protein><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Calvaria><Cas nuclease technology><Cell Body><Cell Culture Techniques><Cell Differentiation><Cell Differentiation process><Cell Therapy><Cells><Cellular Matrix><Chicken Homolog of Gicerin><Clinical><Clinical Trials><Clone Cells><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Course Content><Cytoskeletal System><Cytoskeleton><Data><Defect><Dental><Development><Development Plans><Development and Research><Educational workshop><Elements><Family><Fat Cells><Fats><Fatty Tissue><Fatty acid glycerol esters><Future><Gene Deletion><Genes><Goals><Heterograft><Heterologous Transplantation><Histology><Human><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Immunosuppressed Host><Implant><In Vitro><Investigators><Knock-out><Knockout><Lead><Lipocytes><MCAM><MCAM gene><MUC18><Mature Lipocyte><Mature fat cell><Melanoma Adhesion Molecule><Melanoma-Associated Glycoprotein MUC18><Mentors><Mesenchymal><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Modeling><Modern Man><Molecular><Monomeric G-Proteins><Monomeric GTP-Binding Proteins><NGS Method><NGS system><Network Analysis><Organ><Orthodontics><Pathway Analysis><Pathway interactions><Pb element><Pericapillary Cell><Pericytes><Perivascular Cell><Physiologic Ossification><Physiological Ossification><Play><Population><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Predisposition><Progenitor Cells><Property><R & D><R&D><Regenerative Medicine><Regulation><Reporter><Research><Research Associate><Research Personnel><Researchers><Role><Rouget Cells><Science><Scientist><Signal Pathway><Small G-Proteins><Small GTPases><Source><Susceptibility><T lymphoma invasion and metastasis><T-Lymphoma Invasion and Metastatis Inducing Protein 1><TIAM1><TIAM1 Protein><TIAM1 gene><Techniques><Testing><Therapeutic><Thinking><Tissue Engineering><Tissues><Training><Translational Research><Translational Science><Universities><Work><Workshop><Xenograft><Xenograft procedure><Xenotransplantation><adipose><arthritic><bioengineered tissue><biosynthesis><bone><bone cell><bone repair><calvarial><career><career development><cartilage regeneration><cell based intervention><cell culture><cell cultures><cell mediated intervention><cell mediated therapies><cell preparation><cell-based therapeutic><cell-based therapy><cellular differentiation><cellular therapeutic><cellular therapy><clinical relevance><clinically relevant><comparative><course curriculum><craniofacial><craniofacies><developmental><differential expression><differentially expressed><engineered tissue><gene deletion mutation><global gene expression><global transcription profile><glycoprotein MUC18><heavy metal Pb><heavy metal lead><human tissue><immunosuppressed patient><in vivo><inhibitor><interest><intracellular skeleton><knowledgebase><medical college><medical schools><melanoma cell adhesion molecule><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><mineralization><multidisciplinary><multipotency><multipotent><next gen sequencing><next generation sequencing><nextgen sequencing><normal ossification><novel><ossification><osteogenic><overexpress><overexpression><pathway><post-doc><post-doctoral><post-doctoral trainee><precursor cell><progenitor biology><progenitor cell biology><progenitor cell differentiation><progenitor cell fate><progenitor differentiation><progenitor fate><regenerate bone><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regeneration potential><regenerative potential><research and development><research associates><rho><scRNA sequencing><scRNA-seq><school of medicine><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skeletal><skeletal tissue><skills><small molecule><social role><soft tissue><stem and progenitor biology><stem and progenitor cell fate><stem and progenitor differentiation><stem cell biology><stem cell differentiation><stem cell fate><stem cells><thoughts><tissue progenitor><tissue regeneration><tissue regrowth><tissue renewal><tissue specific progenitor cells><tissue specific regeneration><tissue specific stem cells><tissue stem cells><tomography><transcriptional differences><transcriptome><transcriptomics><transdifferentiation><translation research><translational applications><translational investigation><vascular><white adipose tissue><xeno-transplant><xeno-transplantation><yellow adipose tissue>
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Marios Arvanitis

OHIO STATE UNIVERSITY, Columbus, OH

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$165,563
FY 2026

Project Title

From genotype to phenotype in a GWAS locus: the role of REST in atherosclerosis

Grant Number:

7K08HL166690-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary This K08 mentored clinical scientist research career development award is a five-year program designed to facilitate Dr. Marios Arvanitis’ (PI) development into an independent physician-investigator in vascular genetics. Atherosclerotic cardiovascular disease (ASCVD) is a major publ...

Research Terms

<7B4 Antigen><7B4 protein><ASCVD><Adeno-Associated Viruses><Advisory Committees><Affect><Alleles><Allelomorphs><Aorta><Arteries><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Award><Basal Transcription Factor><Basal transcription factor genes><Bayesian Method><Bayesian Methodology><Bayesian Statistical Method><Bayesian approaches><Bayesian classification method><Bayesian classification procedure><Bayesian posterior distribution><Binding Sites><Biology><Blood Vessels><Body Tissues><CALL protein><CD144 Antigen><CD31><CRE Recombinase><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CamL1 Gene Product><Cardiovascular Diseases><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cas nuclease technology><Cause of Death><Cell Surface Glycoprotein L1><Cellular Assay><Cessation of life><ChIP Sequencing><ChIP assay><ChIP-seq><ChIPseq><Chromosome 4><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Co(beta)-cyano-7''-(2-methyl)adeninylcobamide><Combining Site><Coronary Arteriosclerosis><Coronary Artery Disease><Coronary Artery Disorder><Coronary Atherosclerosis><Coronary Disease><Coronary heart disease><DNA><Data><Data Set><Death><Deoxyribonucleic Acid><Dependoparvovirus><Dependovirus><Development><Disease><Disorder><Distal><Distant><ENOS><Endothelial Cells><Endothelial Nitric Oxide Synthase><Endothelium><Enhancers><Enterobacteria phage P1 Cre recombinase><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exposure to><F11 Glycoprotein><Functional RNA><Funding><Future><GWA study><GWAS><Gene Inactivation><Gene Silencing><Gene Targeting><Gene variant><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Risk><Genomics><Genotype><Heritability><High Fat Diet><Human><Human Genetics><Immunofluorescence><Immunofluorescence Immunologic><In Vitro><Individual><Injections><Investigation><Investigators><K-Awards><K-Series Research Career Programs><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><L1 Cell Adhesion Molecule><L1CAM><Laboratories><LoxP-flanked allele><MMPs><Matrix Metalloproteinases><Mediating><Mentors><Mesenchymal><Methods><Mice><Mice Mammals><Modern Man><Multiomic Data><Murine><Mus><NGF-Inducible Glycoprotein><NILE Glycoprotein><NILE Protein><NOS3><NOS3 gene><Nerve Growth Factor-Inducible Large External Glycoprotein><Network Analysis><Neural Adhesion Molecule L1><Neural Cell Adhesion Molecule L1><Nitric Oxide Synthase 3><Noncoding RNA><Nontranslated RNA><Null Mouse><PECAM1><PECAM1 gene><Pathway Analysis><Pathway interactions><Permeability><Phenotype><Physicians><Population><Postdoc><Postdoctoral Fellow><Proteins><Public Health><Publishing><RNA Seq><RNA sequencing><RNAseq><Reactive Site><Research><Research Associate><Research Career Program><Research Personnel><Researchers><Rest><Risk-associated variant><Role><SOX18><SOX18 gene><SRY-Box 18><Scientist><Short interfering RNA><Site><Small Interfering RNA><Tamoxifen><Task Forces><Testing><Time><Tissues><Transcription Factor Proto-Oncogene><Transcription factor genes><Translating><Type III nitric oxide synthase><United States><Untranslated RNA><Upstream Stimulatory Factor><Upstream Transcription Factor><VE-Cadherin><Variant><Variation><Vascular Endothelial Cadherin><Vascular Endothelial Cadherin 1><Vascular Endothelial Cell><Vascular Endothelium><Woman><Work><adeno associated virus group><advisory team><allelic variant><angiogenesis><atheromatosis><atherosclerotic coronary disease><atherosclerotic disease><atherosclerotic vascular disease><bacteriophage P1 recombinase Cre><cadherin 5><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><cell assay><chromatin immunoprecipitation><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><coronary arterial disease><coronary disorder><data integration><design><designing><developmental><disease risk><disorder risk><effective therapy><effective treatment><epigenetically><experiment><experimental research><experimental study><experiments><factor A><floxed><floxed allele><gene locus><genetic analysis><genetic approach><genetic locus><genetic strategy><genetic variant><genome editing><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic editing><genomic location><genomic locus><genomic variant><global gene expression><global transcription profile><helix-loop-helix activator USF><human disease><human progenitor><human progenitor cell derived><human stem cell-derived><human stem cells><in vivo><induced Cre><inducible Cre><insight><men><migration><mouse model><multidisciplinary><multiple omic data><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><noncoding><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><overexpress><overexpression><pathway><post-doc><post-doctoral><post-doctoral trainee><progenitor cell differentiation><progenitor differentiation><programs><research associates><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><scATAC sequencing><scATAC-seq><scRNA sequencing><scRNA-seq><siRNA><single cell ATAC-seq><single cell ATAC-sequencing><single cell Assay for Transposase Accessible Chromatin sequencing><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell sequencing assay for transposase accessible chromatin><single cell transcriptomic profiling><single-cell Assay for Transposase-Accessible Chromatin with sequencing><single-cell RNA sequencing><single-cell assay for transposase-accessible chromatin using sequencing><single-cell assay for transposase-accessible chromatin-seq><skills><social role><stem and progenitor differentiation><stem cell differentiation><success><transcription factor><transcription factor MLTF><transcription factor USF><transcriptional silencing><transcriptome><transcriptome sequencing><transcriptomic sequencing><vascular><whole genome association analysis><whole genome association study>
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Rayan Najjar

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$164,808
FY 2026

Project Title

Using Bioinformatics Methodologies to Explore the Role of Short Interspersed Elements in the Pathogenesis of Idiopathic Inflammatory Myopathies

Grant Number:

5K08AR082939-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Idiopathic inflammatory myopathies (IIM) are systemic autoimmune diseases characterized by specific autoantibodies and upregulation of interferon inducible genes but are not completely understood. We propose a testable novel hypothesis in this K08 award to study the role of ...

Research Terms

<21+ years old><7S RNA><7SL RNA><ADAR1><ATAC sequencing><ATAC-seq><ATACseq><Adenosine><Adjuvant><Adult><Adult Human><Adverse effects><Affect><Aicardi Goutieres syndrome><Alternate Splicing><Alternative RNA Splicing><Alternative Splicing><Alu Elements><Alu Family><Alu Repetitive Sequences><Amino Acyl T RNA Synthetases><Amino Acyl-tRNA Ligases><Amino Acyl-tRNA Synthetases><Aminoacyl Transfer RNA Synthetase><Aminoacyl-tRNA Synthetase><Assay for Transposase-Accessible Chromatin using sequencing><Autoantibodies><Autoantigens><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Autologous Antigens><Award><Awareness><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Binding><Bioinformatics><Biology><CREE ENCEPHALITIS><Cell Body><Cell Communication and Signaling><Cell Lineage><Cell Signaling><Cells><Clinical><Code><Coding System><Communication><Complement><Complement Proteins><Complex><Computational Biology><DNA mutation><DNA-Dependent RNA Polymerases><DNA-Directed RNA Polymerase><Data><Data Set><Dermatomyositis><Dermatopolymyositis><Development><Disease><Disorder><Doctor of Philosophy><Double-Stranded RNA><Elements><Encephalopathy with intracranial calcification and chronic lymphocytosis of cerebrospinal fluid><Encephalopathy, familial infantile, with calcification of basal ganglia and chronic cerebrospinal fluid lymphocytosis><Ensure><Environment><Event><Gene Transcription><Generations><Genes><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Genomics><Goals><HPGF><Hepatocyte-Stimulating Factor><Human Genome><Hybridoma Growth Factor><IFN><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Idiopathic Inflammatory Myopathies><IgA Deficiency><Immune><Immune system><Immunes><Immunology><Incubated><Inflammatory><Inflammatory Muscle Diseases><Inflammatory Myopathy><Infrastructure><Innate Immune System><Inosine><Interferon Type I><Interferons><Interleukin-6><Intervening Sequences><Intracellular Communication and Signaling><Introns><Investigators><Knowledge><Lupus Erythematosus Disseminatus><MGI-2><Mentors><Methodology><Modeling><Molecular><Molecular Interaction><Muscle><Muscle Tissue><Mutation><Mutation Detection><Myeloid Differentiation-Inducing Protein><Myositis><NIH><National Institutes of Health><Nature><Non-Polyadenylated RNA><PBMC><Paramyxoviridae><Paramyxovirus><Pathogenesis><Pathogenicity><Patients><Peripheral Blood Mononuclear Cell><Ph.D.><PhD><Plasmacytoma Growth Factor><Polymyositis-Dermatomyositis><Process><Production><Proteins><RNA><RNA Editing><RNA Expression><RNA Gene Products><RNA Polymerases><RNA Seq><RNA Splicing><RNA sequencing><RNA, Messenger, Editing><RNAseq><Research><Research Personnel><Researchers><Ribonucleic Acid><Risk><Role><SINEs><SLE><Sampling><Scientist><Self-Antigens><Short Interspersed DNA Sequence Elements><Short Interspersed Element><Short Interspersed Nucleotide Elements><Short interfering RNA><Signal Recognition Particle><Signal Transduction><Signal Transduction Systems><Signaling><Site><Small Interfering RNA><Specificity><Splicing><Structure><Systemic Lupus Erythematosus><Systemic Lupus Erythematous><Systemic Lupus Erythmatosus><Technology><Testing><Therapeutic><Training><Training Programs><Transcript><Transcription><Transfer RNA><Transfer RNA Synthetase><Triplet Codon-Amino Acid Adaptor><United States National Institutes of Health><Universities><Upregulation><Variant><Variation><Viral><Washington><adulthood><aminoacid tRNA ligase><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><autoimmune antibody><autoimmune condition><autoimmune disorder><autoimmunity disease><autoreactive B cell><autoreactive antibody><bio-informatics tool><bioinformatics tool><biological signal transduction><career><cell type><complementation><computer biology><computer program><computer programming><developmental><disseminated lupus erythematosus><dsRNA><early onset><epigenome><genome mutation><global gene expression><global transcription profile><human whole genome><immunogenic><immunogenicity><immunoglobulin A deficiency><improved><inhibitor><insight><interferon beta 2><knock-down><knockdown><microcephaly-chorioretinopathy syndrome><multidisciplinary><muscular><novel><nucleofection><overexpress><overexpression><prevent><preventing><pseudotoxoplasmosis syndrome><rheumatologist><scRNA sequencing><scRNA-seq><self reactive B cell><self reactive antibody><sensor><siRNA><signal recognition particle 7S RNA><signal recogniton particle 7S RNA><single cell RNA-seq><single cell RNAseq><single cell analysis><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><statistics><systemic autoimmune disease><systemic autoimmune disorder><systemic lupus erythematosis><tRNA><tRNA Synthetase><transcriptome><transcriptome sequencing><transcriptomic sequencing><transfer Ribonucleic acids>
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Jessica Fortin

PURDUE UNIVERSITY, WEST LAFAYETTE, IN

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$164,430
FY 2026

Project Title

Small molecule inhibitors of hyperphosphorylated tau aggregation in Alzheimer's disease: lead optimization, and proof of concept in a rodent model

Grant Number:

5K08AG071985-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/15/2022

End Date:

4/30/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract The candidate is a medicinal chemist and veterinary pathologist in the Department of Pathobiology and Diagnostic Investigation at Michigan State University (MSU). Her research interests focus on the preparation of small molecules to abrogate the aggregation of hyperphosphory...

Research Terms

<ABC20><ABCB1><ABCB1 gene><AD and related dementia><AD dementia><AD related dementia><ADRD><AMES mutagen test><Acute><Age Months><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Ames Assay><Ames Salmonella/microsome mutagenicity assay><Ames Test><Amyloid (Aβ) plaques><Amyloid Plaques><Animal Model><Animal Models and Related Studies><Area><Assay><BBB crossing><BBB permeabilization><BBB permeable><Behavior><Binding Proteins><Bioassay><Biological><Biological Assay><Blood - brain barrier anatomy><Blood Plasma><Blood-Brain Barrier><Body Tissues><Brain><Brain Nervous System><CaCo2><Caco-2 Cells><Cell Culture Techniques><Cell Death><Cell Protection><Chemical Structure><Chemicals><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Cytoprotection><DNA Molecular Biology><Data><Deposit><Deposition><Development><Diagnostic><Disease Progression><Disturbance in cognition><Dose><Drug Kinetics><Encephalon><Ensure><Equilibrium><Excretory function><Fostering><GP170><Genes><Genetic><Goals><Grant><Hemato-Encephalic Barrier><Human><IP injection><Impaired cognition><In Vitro><In vivo analysis><Intermediary Metabolism><Intestinal Absorption><Intraperitoneal Injections><Investigation><Investigators><Isoforms><Knowledge><Language><Ligand Binding Protein><Ligand Binding Protein Gene><Link><Lytotoxicity><MDR-1><MDR1><MDR1 Protein><MT-bound tau><Measures><Medicinal Chemistry><Medicine><Mentors><Metabolic Processes><Metabolism><Mice><Mice Mammals><Michigan><Microsomes><Modeling><Modern Man><Molecular Biology><Mouse Strains><Movement><Multidrug Resistance 1><Multidrug Resistance Gene-1><Multidrug Resistance Gene-1s><Multidrug Resistance Proteins><Multidrug Resistant Proteins><Murine><Mus><Nerve Degeneration><Neuritic Plaques><Neurofibrillary Tangles><Neuron Degeneration><Neurosciences><Neurosciences Research><Organ><Organic Chemistry><P-GP><P-Glycoprotein><P-Glycoprotein 1 Gene><PGY-1 Protein><PGY1><PK/PD><Pathologic><Pathologist><Permeability><Pharmaceutic Chemistry><Pharmaceutical Agent><Pharmaceutical Chemistry><Pharmaceuticals><Pharmacokinetics><Pharmacologic Substance><Pharmacological Substance><Plasma><Plasma Serum><Preclinical Testing><Preclinical data><Preparation><Primary Senile Degenerative Dementia><Property><Protein Binding><Protein Isoforms><Recombinants><Research><Research Personnel><Researchers><Reticuloendothelial System, Serum, Plasma><Rodent Model><Safety><Senile Plaques><Solubility><Tau forming aggregates><Tauopathies><Technology><Testing><Time><Tissues><Toxicology><Training><Transgenic Mice><Transgenic Organisms><Translational Research><Translational Science><Universities><Veterinary Medicine><abnormally aggregated tau protein><absorption><aggregation in tau><amyloid beta plaque><amyloid-b plaque><aβ plaques><balance><balance function><biologic><blood-brain barrier crossing><blood-brain barrier permeabilization><blood-brain barrier permeable><bloodbrain barrier><bloodbrain barrier crossing><bloodbrain barrier permeabilization><bloodbrain barrier permeable><body movement><bound protein><cell culture><cell cultures><cognitive dysfunction><cognitive loss><college><collegiate><cored plaque><cytoprotective><cytotoxicity><design><designing><developmental><diffuse plaque><drug development><drug discovery><efficacy study><excretion><filamentous tau inclusion><gastrointestinal absorption><hydrophilicity><hyper-phosphorylated tau><hyperphosphorylated tau><improved><in vitro Model><in vivo><in vivo evaluation><in vivo testing><inhibitor><interest><lead optimization><lipophilicity><microtubule associated protein tau aggregation><microtubule associated protein tau deposit><microtubule bound tau><microtubule-bound tau><model of animal><mouse model><multidisciplinary><murine model><mutant><necrocytosis><neural degeneration><neurodegeneration><neurodegenerative><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neurological degeneration><neuron toxicity><neuronal degeneration><neuronal toxicity><neuropathologic tau><neuropathological tau><neurotoxic><neurotoxicity><novel><p-tau><p-τ><paired helical filament of tau><pharmaceutical><pharmacokinetics and pharmacodynamics><phospho-tau><phospho-τ><phosphorylated tau><post-translational modification of tau><posttranslational modification of tau><pre-clinical><pre-clinical study><pre-clinical testing><preclinical><preclinical findings><preclinical information><preclinical study><preparations><primary degenerative dementia><programs><safety assessment><screening program><self-aggregate tau><senile dementia of the Alzheimer type><skills><small molecular inhibitor><small molecule><small molecule inhibitor><small molecule therapeutics><spatial and temporal><spatial temporal><spatiotemporal><tangle><tau><tau PHF><tau Proteins><tau accumulation><tau aggregate><tau aggregation><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau fibrillation><tau fibrillization><tau filament><tau inclusion><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neurofibrillary tangle><tau neuropathology><tau oligomer><tau paired helical filament><tau pathology><tau pathophysiology><tau phosphorylation><tau polymerization><tau posttranslational modification><tau protein accumulation><tau protein aggregation><tau proteinopathy><tau related neurodegeneration><tau-1><tau-induced pathology><tau-tau interaction><tauopathic neurodegenerative disorder><tauopathy><transgenic><translation research><translational investigation><translational study><τ Proteins><τ aggregation><τ phosphorylation>
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Joseph Stanley Bednash

OHIO STATE UNIVERSITY, Columbus, OH

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$163,620
FY 2026

Project Title

Transfer RNAs as novel mediators in acute lung injury

Grant Number:

5K08HL169725-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2024

End Date:

4/30/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT This application, “Transfer RNAs as novel mediators in acute lung injury,” is submitted by Joseph S. Bednash, MD for a K08 Mentored Clinical Scientist Research Career Development Award. I am a physician-scientist in the Division of Pulmonary, Critical Care and Sleep Medicine at the Ohio St...

Research Terms

<ARDS><Acute Lung Injury><Acute Pulmonary Injury><Acute Respiratory Distress><Acute Respiratory Distress Syndrome><Adult ARDS><Adult RDS><Adult Respiratory Distress Syndrome><Advisory Committees><Award><Bacterial Infections><Bioinformatics><Biological><Biological Function><Biological Markers><Biological Process><Biology><Body Tissues><Cardiac Diseases><Cardiac Disorders><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Body><Cell Death><Cell Function><Cell Physiology><Cell Process><Cell model><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Stress><Cellular Stress Response><Cellular model><Cessation of life><Clinical><Cognitive><Complex><Critical Care><Critical Illness><Critically Ill><Da Nang Lung><Data><Death><Diffuse><Disease><Disorder><Drug Therapy><EC 2.1.1><EC 2.1.1.31-36><Endotoxins><Ensure><Environment><Experimental Models><Family><Foundations><Functional RNA><Funding><Future><Gene Transcription><Genetic Transcription><Guanine><Health Care Utilization><Heart Diseases><Host Defense><Host Defense Mechanism><Host resistance><Human><Immunology><Immunomodulation><In Vitro><Individual><Infection><Inflammasome><Inflammatory><Injury><K-Awards><K-Series Research Career Programs><KO mice><Knock-out Mice><Knockout Mice><Liquid substance><Lung><Lung Inflammation><Lung Respiratory System><Lung Tissue Fibrosis><Lung damage><Macrophage><Mediator><Medicine><Mentors><Mentorship><Messenger RNA><Metabolic stress><Methylation><Methyltransferase><MicroRNAs><Modeling><Modern Man><Modification><Molecular and Cellular Biology><Myelogenous><Myeloid><Mφ><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Null Mouse><Ohio><Oxidative Stress><P aeruginosa><P. aeruginosa><PBMC><Parents><Pathogenesis><Patients><Peripheral Blood Mononuclear Cell><Pharmacological Treatment><Pharmacotherapy><Physicians><Physiologic><Physiological><Pneumonia><Pneumonitis><Principal Investigator><Proteins><Pseudomonas aeruginosa><Pseudomonas pyocyanea><Pulmonary Fibrosis><Pulmonary Inflammation><QOL><Quality of life><RNA><RNA Expression><RNA Gene Products><RNA Methylases><RNA Seq><RNA Stability><RNA sequencing><RNA, Transfer, Methyltransferases><RNAseq><Regulation><Research><Research Career Program><Ribonucleic Acid><Role><Sampling><Scientist><Shock Lung><Signaling Molecule><Sleep><Source><Specificity><Stiff lung><Stress><Subcellular Process><Survivors><Syndrome><T RNA Methyltransferases><Task Forces><Testing><Tissues><Training><Transcription><Transfer RNA><Translations><Triplet Codon-Amino Acid Adaptor><Universities><Untranslated RNA><Upregulation><Work><advisory team><bacteria infection><bacterial disease><bio-markers><biologic><biologic marker><biomarker><career><career development><cell stress><drug intervention><drug treatment><experience><fibrosis in the lung><fluid><global gene expression><global transcription profile><health care service use><health care service utilization><heart disorder><human disease><immune modulation><immune regulation><immunologic reactivity control><immunomodulatory><immunopathology><immunoregulation><immunoregulatory><inflammatory lung disease><inhibitor><injuries><injury to tissue><insight><liquid><lung fibrosis><lung injury><mRNA><methylase><miRNA><microbial><mouse model><murine model><necrocytosis><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><noncoding><novel><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapy target><parent><pathogen><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><posttranscriptional><preservation><prevent><preventing><professor><programs><psychologic><psychological><pulmonary><pulmonary damage><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><respiratory><skills><social role><stressor><success><tRNA><tRNA Methyltransferases><tissue injury><transcriptome><transcriptome sequencing><transcriptomic sequencing><transfer Ribonucleic acids><translation><translational clinician><translational physician><translational progress><translational progression><translational study><transmethylase><wet lung>
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RAMON JIN

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$161,978
FY 2026

Project Title

The Role of SOX2 and CDX2 in Barrett's Esophagus Development

Grant Number:

5K08DK139376-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/1/2024

End Date:

4/30/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY / ABSTRACT This K08 application proposes a five-year career development and research program focused on elucidat- ing the transcriptional determinants and molecular heterogeneity of Barrett’s esophagus (BE). The applicant, Ramon Jin, M.D., Ph.D., is a physician-scientist and an Instr...

Research Terms

<21+ years old><Acid Reflux><Address><Adenocarcinoma of the Esophagus><Adult><Adult Human><Alimentary Canal><Animal Model><Animal Models and Related Studies><Assay><Autoregulation><Award><Barrett Esophagus><Barrett Syndrome><Barrett Ulcer><Basal Transcription Factor><Basal transcription factor genes><Bile Acids><Bioassay><Bioinformatics><Biological Assay><Body Tissues><CDX-3><CDX2><CDX2 gene><CDX3><CRE Recombinase><Cancers><Caudal Type Homeobox Transcription Factor 2><Caudal-Type Homeo Box Transcription Factor 3><Caudal-Type Homeobox Protein 2><Caudal-Type Homeobox Transcription Factor 3><Cellular biology><Characteristics><Chronic><Columnar Epithelial-Lined Lower Esophagus><Columnar Epithelium><Columnar Metaplasia><Columnar-Lined Esophagus><Community Integration><Culture Techniques><Data><Development><Development Plans><Development and Research><Digestive Tract><Doctor of Medicine><Doctor of Philosophy><Ensure><Enterobacteria phage P1 Cre recombinase><Epithelium><Equilibrium><Esophageal Adenocarcinoma><Esophageal Cancer><Esophageal Reflux><Esophagus><Esophagus Cancer><Fellowship><Foregut><Foundations><Funding><GERD><GI Tract><GMO Animals><Gastro-oesophageal Reflux><Gastroesophageal Reflux><Gastroesophageal reflux disease><Gastrointestinal Tract><Gastrointestinal tract structure><Gene Modified><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genetic><Genetic Transcription><Genetically Modified Animals><Genomics><Grant><Grant Review><Growth><Hematology><Heterogeneity><Hindgut><Histologic><Histologically><Homeobox Protein CDX-2><Homeostasis><Human><Incidence><Insulin Regulating Transcription Factor CDX3><Intestinal><Intestinal Metaplasia><Intestines><Knock-out><Knockout><Knowledge><Laboratories><Leadership><Learning><Lineage Tracing><LoxP-flanked allele><M.D.><Maintenance><Malignant Esophageal Neoplasm><Malignant Esophageal Tumor><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Esophagus><Malignant neoplasm of esophagus><Manuscripts><Medicine><Mentors><Mentorship><Metaplasia><Metaplastic Change><Mice><Mice Mammals><Modern Man><Molecular><Multiomic Data><Murine><Mus><Oncogenesis><Oncology><Oncology Cancer><Organoids><Patients><Pattern><Ph.D.><PhD><Phenotype><Physicians><Physiological Homeostasis><Precancerous Conditions><Premalignant Condition><Premalignant State><Preparation><Primitive foregut structure><Process><Proteins><Proteomics><Publications><R & D><R&D><RNA Expression><Regulation><Repression><Research><Risk Factors><Role><Scientific Publication><Scientist><Series><Squamous Cell><Squamous Epithelium><Stomach><Technical Expertise><Techniques><Testing><Time><Tissue Growth><Tissues><Training><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Variant><Variation><Work><adulthood><alimentary tract><bacteriophage P1 recombinase Cre><balance><balance function><biobank><biorepository><bowel><career development><cell biology><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><choleate><college><collegiate><deoxycholate><developmental><digestive canal><epigenomics><esophageal intestinal metaplasia><esophagogastric cancer><experience><experiment><experimental research><experimental study><experiments><expression subtypes><floxed><floxed allele><gastric><gastroesophageal cancer><gastrointestinal><gene modification><genetically modified><induced Cre><inducible Cre><innovate><innovation><innovative><insight><instructor><malignancy><meeting><meetings><model of animal><molecular sub-types><molecular subsets><molecular subtypes><mouse model><multiomics><multiple omic data><multiple omics><murine model><neoplasm/cancer><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><oesophageal cancer><ontogeny><overexpress><overexpression><panomics><precancer><precancerous><precancerous state><premalignant><preparations><prevent><preventing><programs><proteogenomics><research and development><response><restoration><skills><social role><technical skills><tool><trait><transcription factor><transcriptomics><tumorigenesis>
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Chen-Han Wilfred Wu

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$161,829
FY 2026

Project Title

A comprehensive approach to understanding the genetic causes of urinary stone disease: combining monogenic and polygenic analyses

Grant Number:

7K08DK135933-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Title: A comprehensive approach to understanding the genetic causes of urinary stone disease: combining monogenic and polygenic analyses One in eight Americans is affected by Urinary Stone Diseases (USDs), with 52% of them experiencing recurrence within 10 years. Despite the...

Research Terms

<21+ years old><Abdominal colic><Accounting><Address><Adult><Adult Human><Advisory Committees><Affect><American><Applications Grants><Biometrics><Biometry><Biostatistics><Calcium><Career Mobility><Causality><Childhood><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinical><Clinical Trials><Colic><Colicky Pain><Complex><Development><Development Plans><Diet><Disease><Disorder><Doctor of Philosophy><Drug Therapy><EXTMR><Environmental Factor><Environmental Risk Factor><Epidemiology><Ethnic Origin><Ethnicity><Etiology><Extramural><Extramural Activities><Five-Year Plans><Future><GWA study><GWAS><Gene variant><Genes><Genetic><Genetic study><Goals><Grant><Grant Proposals><Grouping><Health><Heritability><High Prevalence><Intervention><Investigators><Literature><Medical Care Costs><Medicine><Mentors><Mentorship><Modeling><Morbidity><NGS Method><NGS system><NIH><National Institutes of Health><Nature><Outcome><Pathogenesis><Pathogenicity><Patient Care><Patient Care Delivery><Patient Recruitments><Patients><Ph.D.><PhD><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Pharmacological Treatment><Pharmacotherapy><Physicians><Physiology><Prevalence><Preventative strategy><Prevention strategy><Preventive strategy><Radiation exposure><Recurrence><Recurrent><Reporting><Research><Research Personnel><Researchers><Risk><Risk Factors><Risk-associated variant><Role><Science><Scientist><Single Base Polymorphism><Single Nucleotide Polymorphism><Structure><Task Forces><Technology><Training><United States National Institutes of Health><Urinary Calculi><Urinary Stones><Urinary Tract Stones><Urolith><Urology><Variant><Variation><Vegetables><Water Intake><Water consumption><Work><adulthood><advisory team><allelic variant><care for patients><care of patients><career advancement><career development><career transition><caring for patients><causation><chronic kidney disease><cohort><conference><convention><cost><developmental><dietary vegetable><diets><disease causation><drug intervention><drug treatment><early onset><economic impact><entire genome><environmental intervention><environmental risk><epidemiologic><epidemiological><exome><exome sequencing><exome-seq><experience><full genome><gene interaction><genetic variant><genome scale><genome sequencing><genome wide association><genome wide association scan><genome wide association study><genome-wide><genomewide><genomewide association scan><genomewide association study><genomic variant><groupings><improved><medical college><medical costs><medical expenses><medical schools><next gen sequencing><next generation sequencing><nextgen sequencing><novel><participant recruitment><pathogenicity gene><patient stratification><pediatric><pharmaceutical><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><polygenetic risk scores><polygenic risk score><precision medicine><precision-based medicine><recurrence prevention><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><scaffold><scaffolding><school of medicine><single nucleotide variant><skills><social role><stratified patient><summit><symposia><symposium><trait><treatment strategy><virulence gene><virulent gene><whole genome><whole genome association analysis><whole genome association study>
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Tomeka L Suber

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$160,736
FY 2026

Project Title

Intrapulmonary itaconate as a host-protective metabolite during ER Stress and Klebsiella pneumoniae infection

Grant Number:

5K08HL163324-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT ABSTRACT Gram negative bacteria are the most common pathogens implicated in nosocomial pneumonia in critically ill patients. Klebsiella pneumoniae (KP) in particular has grown in prominence worldwide with increasing prevalence of antibiotic resistance, hypervirulent strains, and invasive cli...

Research Terms

<1-Propene-1,2,3-tricarboxylic acid><Achilleic Acid><Aconitate><Aconitic Acid><Acontic Acid><Acute><Acute Lung Injury><Acute Pulmonary Injury><Address><Adonic Acid><Affect><Alveolar Macrophages><Antibiotic Resistance><Bacteria><Basic Research><Basic Science><Biology><Bleo><Bleomycin><Blood monocyte><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Carboxy-Lyases><Carboxyglutaconic Acid><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Body><Cell Death><Cell Line><Cell Survival><Cell Viability><CellLine><Cells><Cellular Stress><Cellular Stress Response><Cellular biology><Cellular injury><Chimera><Chimera organism><Citric Acid Cycle><Citridic Acid><Citridinic Acid><Clinical><Critical Care><Critical Illness><Critically Ill><Death Rate><Decarboxylases><Development Plans><ER stress><Elderly><Enzyme Gene><Enzymes><Epithelial Cells><Equilibrium><Equisetic Acid><Exhibits><Experimental Models><Exposure to><Fibroblasts><Focal Infection><Foundations><Goals><Gram-Negative Bacteria><Hospital Admission><Hospitalization><Host Defense><Host Defense Mechanism><Human><Immune><Immunes><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunologic Subtyping><Immunophenotyping><Immunosuppressed Host><In Vitro><Infection><Inflammation><Inflammatory Response><Injury><Intensive Care Units><Interferon Type I><Intermediary Metabolism><Investigators><K pneumoniae><K-Awards><K-Series Research Career Programs><K. pneumoniae><KO mice><Klebsiella pneumoniae><Knock-out Mice><Knockout Mice><Knowledge><Krebs Cycle><Lipopolysaccharides><Lower Respiratory Tract Infection><Lower respiratory infection><Lung><Lung Alveolar Epithelia><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Lung Tissue Fibrosis><Lung infections><Macrophage><Marrow monocyte><Mediator><Medicine><Mentors><Mentorship><Metabolic><Metabolic Processes><Metabolism><Mice><Mice Mammals><Mitochondria><Modeling><Modern Man><Multi-Drug Resistance><Multidrug Resistance><Multiple Drug Resistance><Multiple Drug Resistant><Murine><Mus><Myelogenous><Myeloid><Myeloid Cells><Mφ><Nosocomial pneumonia><Null Mouse><Outcome><Pathway interactions><Patients><Physicians><Pneumonia><Population><Predisposition><Prevalence><Production><Proliferating><Proteins><Publishing><Pulmonary Fibrosis><Pulmonary Macrophages><Pyrocitric Acid><Regulation><Research><Research Career Program><Research Personnel><Researchers><Resistance to Multi-drug><Resistance to Multidrug><Resistance to Multiple Drug><Resistance to antibiotics><Resistant to Multiple Drug><Resistant to antibiotics><Resistant to multi-drug><Resistant to multidrug><Resolution><Role><Scientist><Sepsis><Short interfering RNA><Single Base Polymorphism><Single Nucleotide Polymorphism><Slice><Small Interfering RNA><Source><Specificity><Strains Cell Lines><Structure of parenchyma of lung><Susceptibility><Syndrome><Systemic disease><TCA cycle><Techniques><Testing><Tissues><Training><Translational Research><Translational Science><Tricarboxylic Acid Cycle><Work><Wound Repair><advanced age><alveolar epithelium><antibiotic drug resistance><antibiotic resistant><balance><balance function><biological adaptation to stress><career development><cell biology><cell damage><cell injury><cell stress><cellular damage><chimeras><conditional knock-out><conditional knockout><cultured cell line><cytokine><damage to cells><defense response><develop therapy><effective therapy><effective treatment><endoplasmic reticulum stress><epithelial injury><fibrosis in the lung><geriatric><healthcare-associated pneumonia><hospital acquired pneumonia><hospital associated pneumonia><immunosuppressed patient><improved><improved outcome><in vivo><in vivo Model><infection localized><injuries><injury to cells><injury to tissue><interest><intervention design><intervention development><knock-down><knockdown><local infection><lung fibrosis><metabolism measurement><metabolomics><metabonomics><mitochondrial><monocyte><mortality><mortality rate><mouse model><multi-drug resistant><multidisciplinary><multidrug resistant><murine model><necrocytosis><novel><pathogen><pathway><patient population><physiological defense response><pneumonia model><pneumonia models><programs><pulmonary><pulmonary infections><reactioncrisis><resilience><resilient><resistance in K pneumoniae><resistance in K. pneumoniae><resistance in Klebsiella pneumoniae><resistant K pneumoniae><resistant K. pneumoniae><resistant Klebsiella pneumoniae><resolutions><response><senior citizen><siRNA><single nucleotide variant><skills><social role><stress response><stressreaction><stressor><success><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapy design><therapy development><tissue injury><tool><transcriptomics><translation research><translational investigation><treatment design><treatment development><wound healing><wound recovery><wound resolution>
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Sydney Ilima Ramirez

LA JOLLA INSTITUTE FOR IMMUNOLOGY, LA JOLLA, CA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$159,300
FY 2026

Project Title

Human upper airway immune memory kinetics and durability against respiratory pathogens

Grant Number:

1K08AI196260-01

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/2/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Peripheral blood is the primary sample type collected to evaluate a vast range of medical conditions. However, peripheral blood testing may not reflect processes occurring in tissue, like the upper airway. The SARS- CoV-2 (SARS2) pandemic highlighted the importance of being able to ...

Research Terms

<2019 novel corona virus><2019 novel coronavirus><2019-nCoV><2019-nCoV variant><2019-nCoV variant forms><2019-nCoV variant strains><21+ years old><Acute Nasopharyngitis><Address><Adult><Adult Human><Animal Model><Animal Models and Related Studies><Antibodies><Antibody Response><Antibody titer measurement><Antigenic Determinants><Antigens><Appointment><Award><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Binding Determinants><Blood Sample><Blood Tests><Blood specimen><Body Tissues><Booster Immunization><CAIV-T><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 booster><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 exposure><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 immunity><COVID-19 infection><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 vaccination><COVID-19 vaccine booster><COVID-19 variant><COVID-19 variant forms><COVID-19 variant strains><COVID-19 virus><COVID-19 virus infection><COVID-19 years><COVID19 infection><COVID19 virus><California><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Cell Body><Cell Survival><Cell Viability><Cell secretion><Cells><Cellular Secretion><Clinical><CoV-2><CoV2><Common Cold><Communicable Diseases><Complex><Conchae Nasales><Consultations><Coronaviridae><Coronaviridae Infections><Coronavirus><Coronavirus Infections><Data><Development><Disease><Disorder><Doctor of Philosophy><Enrollment><Environment><Epitopes><Evaluation><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><FluMist><Frequencies><Funding><Grippe><Hematologic Tests><Hematological Tests><Hematology Testing><Human><IgA><Immune><Immune memory><Immunes><Immunity><Immunization><Immunochemical Immunologic><Immunoglobulin A><Immunologic><Immunologic Memory><Immunologic Subtyping><Immunological><Immunological Memory><Immunologically><Immunologics><Immunology><Immunophenotyping><Infection><Infection Control><Infection prevention><Infectious Diseases><Infectious Disorder><Influenza><Influenza Vaccines><Institution><Intramuscular><Investigation><Investigators><K-Awards><K-Series Research Career Programs><Kinetics><Knowledge><Left><Licensing><MHC Receptor><Maintenance><Major Histocompatibility Complex Receptor><Mediating><Medical><Memory><Memory B Cell><Memory B-Lymphocyte><Mentorship><Methods><Modern Man><Morbidity><Mucosa><Mucosal Immune Responses><Mucosal Immunity><Mucosal Tissue><Mucous Membrane><Nasal><Nasal Passages Nose><Nasal cavity><Nasal turbinate bone structure><Nasopharynx><Nose><Orthocoronavirinae><Patients><Ph.D.><PhD><Physicians><Play><Population><Post-vaccination infection><Prevent infection><Primates><Primates Mammals><Process><Public Health><Reproducibility><Research><Research Career Program><Research Personnel><Research Resources><Researchers><Resolution><Resources><Respiratory System, Nose, Nasal Passages><Respiratory infectious agent><Respiratory tract pathogen><Rhinopharynx><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 booster><SARS-CoV-2 epidemic><SARS-CoV-2 exposure><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 immunity><SARS-CoV-2 infection><SARS-CoV-2 pandemic><SARS-CoV-2 vaccination><SARS-CoV-2 vaccine booster><SARS-CoV-2 variant><SARS-CoV-2 variant forms><SARS-CoV-2 variant strains><SARS-CoV2><SARS-CoV2 exposure><SARS-CoV2 infection><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Sampling><Scientist><Secondary Immunization><Services><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 exposure><Severe acute respiratory syndrome coronavirus 2 immunity><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 pandemic><Severe acute respiratory syndrome coronavirus 2 vaccination><Severe acute respiratory syndrome related corona virus 2><Severity of illness><Site><Source><Swab><T cell response><T-Cell Antigen Receptors><T-Cell Receptor><T-Cells><T-Lymphocyte><T8 Cells><T8 Lymphocytes><Testing><Time><Tissues><Training><Turbinates><Universities><Vaccination><Vaccine Design><Vaccines><Viral><Viral Diseases><Virus Diseases><Wuhan coronavirus><acquired immunity><adaptive immunity><adulthood><anamnestic reaction><antibody titering><booster against COVID-19><booster against SARS-CoV-2><booster vaccination><breakthrough infection><career development><cohort><consultation><corona virus><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 exposure><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 immunity><coronavirus disease 2019 infection><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease 2019 vaccination><coronavirus disease 2019 variant><coronavirus disease 2019 variant forms><coronavirus disease 2019 variant strains><coronavirus disease 2019 virus><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus disease-19 virus><cross reactivity><cytokine><developmental><disease severity><enroll><experiment><experimental research><experimental study><experiments><exposure to COVID-19><exposure to SARS-CoV-2><exposure to SARS-CoV2><exposure to Severe acute respiratory syndrome coronavirus 2><exposure to coronavirus disease 2019><flow cytophotometry><flu><flu vaccine><flu virus vaccine><hCoV19><human pathogen><immunity against COVID-19><immunity against SARS-CoV-2><immunity against Severe acute respiratory syndrome coronavirus 2><immunity against coronavirus disease 2019><immunity to COVID-19><immunity to SARS-CoV-2><immunity to Severe acute respiratory syndrome coronavirus 2><immunity to coronavirus disease 2019><immunogen><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><infection with SARS-CoV-2><influenza virus vaccine><insight><interest><life-threatening COVID><life-threatening COVID-19><life-threatening SARS-CoV-2><life-threatening coronavirus disease><life-threatening coronavirus disease 2019><life-threatening severe acute respiratory syndrome coronavirus 2><live attenuated flu vaccine><live attenuated influenza vaccine><live attenuated influenza virus vaccine><minimally invasive><model of animal><mortality><mucosal vaccine><nCoV2><nasopharnygeal><nasopharyngeal swab><neutralizing antibody><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><new vaccines><next generation therapeutics><next generation vaccines><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><novel vaccines><pandemic><pandemic disease><peripheral blood><professor><resolutions><respiratory pathogen><respiratory virus><response><scRNA sequencing><scRNA-seq><secondary immune response><serious COVID><serious COVID-19><serious SARS-CoV-2><serious coronavirus disease><serious coronavirus disease 2019><serious severe acute respiratory syndrome coronavirus 2><severe COVID><severe COVID-19><severe COVID19><severe SARS-CoV-2><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><severe acute respiratory syndrome coronavirus 2 variant><severe acute respiratory syndrome coronavirus 2 variant forms><severe acute respiratory syndrome coronavirus 2 variant strains><severe coronavirus disease><severe coronavirus disease 19><severe coronavirus disease 2019><severe severe acute respiratory syndrome coronavirus 2><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><thymus derived lymphocyte><vaccinate against COVID-19><vaccinate against SARS-CoV-2><vaccinate against coronavirus disease 2019><vaccinate against severe acute respiratory syndrome coronavirus 2><vaccination against COVID-19><vaccination against SARS-CoV-2><vaccination against Severe acute respiratory syndrome coronavirus 2><vaccination against coronavirus disease 2019><vaccine against flu><vaccine against influenza><viral infection><virus infection><virus-induced disease>
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Rachel Laura Wolfson

HARVARD MEDICAL SCHOOL, BOSTON, MA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$158,868
FY 2026

Project Title

Mechanisms of mechanosensation and inflammation-induced hypersensitivityin colon innervating DRG sensory neurons

Grant Number:

5K08DK140638-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2024

End Date:

4/30/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Sensation of the gastrointestinal (GI) tract is necessary for physiologic and pathophysiologic processes. During inflammatory bowel disease (IBD), colonic inflammation induces a hypersensitivity to mechanical stimuli, triggering abdominal pain. The sensory neurons that inne...

Research Terms

<ADRA2 Gene><ADRA2A gene><ADRAR><ADRAR Gene><Abdominal Pain><Accounting><Adra2a><Advisory Committees><Affect><Afferent Neurons><Alimentary Canal><Alpha-2A Gene Adrenoceptor><Alpha-2A-Adrenergic Receptor Gene><Anatomic Sites><Anatomic structures><Anatomy><Assay><Behavior><Behavioral><Bioassay><Biological Assay><Body Tissues><Calcium><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Mechanotransduction><Chest Pain><Children's Hospital><Clinical><Collaborations><Colon><Colonic inflammation><Cytokine Receptors><Data><Data Set><Development and Research><Digestive Tract><Disease><Disorder><Dorsal Root Ganglia><ED visit><ELISA><ER visit><Electrophysiology><Electrophysiology (science)><Emergency care visit><Emergency department visit><Emergency hospital visit><Emergency room visit><Environment><Enzyme-Linked Immunosorbent Assay><Esthesia><Expression Signature><Future><GI Tract><Gastroenterology><Gastrointestinal Motility><Gastrointestinal Tract><Gastrointestinal tract structure><Gene Expression Profile><General Hospitals><Genetic><Goals><Health><Hypersensitivity><Image><In Vitro><In vivo two-photon calcium imaging><Infection><Inflammation><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intracellular Communication and Signaling><Investigators><Ion Channel><Ionic Channels><Knowledge><Laboratories><Lead><Massachusetts><Mechanical Signal Transduction><Mechanics><Mechanosensory Transduction><Mediating><Membrane Channels><Mentors><Mice><Mice Mammals><Molecular><Morphology><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurobiology><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Nociceptors><Pain><Painful><Pathologic><Patients><Pb element><Pediatric Hospitals><Peripheral><Physicians><Physiologic><Physiological><Physiology><Piezo 2><Piezo 2 ion channel><Piezo2><Platelet Type Gene Alpha-2-Adrenergic Receptor><Population><Potassium Chloride><Process><Property><Prostaglandin Receptor><Prostaglandins><Prostanoids><R & D><R&D><Research><Research Personnel><Research Training><Researchers><Role><Scientist><Sensation><Sensory><Sensory Neurons><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Spinal Ganglia><Stimulus><Task Forces><Testing><Tissues><Training><Work><advisory team><alimentary tract><biological signal transduction><bowel inflammation><candidate identification><career><career development><colon distension><conference><convention><cytokine><digestive canal><dorsal root ganglion><electrophysiological><enzyme linked immunoassay><experiment><experimental research><experimental study><experiments><gastrointestinal><gene expression pattern><gene expression signature><gut inflammation><heavy metal Pb><heavy metal lead><imaging><in vivo><in vivo calcium imaging><inflamed bowel><inflamed colon><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><innervation><intestinal autoinflammation><intestinal inflammation><mechanic><mechanical><mechanical force><mechanical stimulus><mechanosensing><mechanotransduction><medical college><medical schools><mouse genetics><mouse model><murine model><nerve supply><neurobiological><neuronal><nociceptive neurons><pain-sensing neurons><pain-sensing sensory neurons><pain-sensing somatosensory neurons><programs><research and development><response><scRNA sequencing><scRNA-seq><school of medicine><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><summit><symposia><symposium><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tenure process><tenure track><therapeutic target><transcriptional profile><transcriptional signature>
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JAMIE LYNN FELTON

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$154,207
FY 2026

Project Title

Genetic and Metabolic Regulation of B Cell Function in Type 1 Diabetes

Grant Number:

1K08DK147614-01

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2031

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT This project is a Mentored Clinical Scientist Research Career Development Award (K08) application for Dr. Jamie Felton, an Assistant Professor of Pediatrics at the Indiana University School of Medicine. Dr. Felton completed clinical training in Pediatric Endocrinology and ha...

Research Terms

<APO2><Adoptive Transfer><Advanced Development><Alleles><Allelomorphs><Anti-CD3 Antibody><Antigen Presentation><Antigen-Antibody Complex><Assay><Autoantibodies><Autoimmune Diseases><Autoimmune Responses><Autoimmune Status><Autoimmunity><Award><B blood cells><B cell><B cell depletion therapy><B cell directed therapy><B cell targeted therapy><B cell therapies><B cell therapy><B cells><B-Cell Development><B-Cell Subsets><B-Cells><B-Lymphocyte Subsets><B-Lymphocytes><B-cell><BACH2><BACH2 gene><BTB and CNC Homology 2><Basic Leucine Zipper Transcription Factor 2><Basic Research><Basic Science><Beta Cell><Bioassay><Biological Assay><Bp50><Brittle Diabetes Mellitus><CD152><CD152 Antigen><CD152 Gene><CD25><CD40><CDW40><CTLA 4><CTLA-4 Gene><CTLA4><CTLA4 gene><CTLA4-TM><Candidate Disease Gene><Candidate Gene><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Communication><Cell Communication and Signaling><Cell Function><Cell Interaction><Cell Physiology><Cell Process><Cell Signaling><Cell-to-Cell Interaction><Cellular Function><Cellular Metabolic Process><Cellular Physiology><Cellular Process><Childhood><Chronic><Class II Genes><Clinical><Clinical Evaluation><Clinical Testing><Complex><Cord Blood><Cost of Illness><Cytotoxic T-Lymphocyte Protein 4><Cytotoxic T-Lymphocyte-Associated Antigen 4><Cytotoxic T-Lymphocyte-Associated Protein 4><Cytotoxic T-Lymphocyte-Associated Serine Esterase-4><DNA Molecular Biology><DR4><Data><Data Set><Death Receptor 4><Dedications><Development><Diabetes Mellitus><Diagnosis><Disease><Disease Costs><Disease Progression><Disease Resistance><Disorder><Endocrinology><Ensure><Fostering><Funding><Future><GWA study><GWAS><Gene Expression><Gene variant><Genetic><Genetic Risk><Genomics><Genotype><Glycolysis><Goals><HLA Class II Genes><HLA-BR><HLA-BR Antigens><HLA-D-Related Antigens><HLA-DR><HLA-DR Antigens><HLA-DR3><HLA-DR3 Antigen><HLA-MT><HLA-MT Antigens><Haplotypes><HuM291><Human><Humulin R><Hypoxia Inducible Factor><IDDM><IL2R><IL2RA><IL2RA gene><Immune Complex><Immune Targeting><Immune destruction><Immune mediated destruction><Immune mediated therapy><Immunologically Directed Therapy><Immunomodulation><Immunotherapy><Inbred NOD Mice><Indiana><Individual><Infant><Inflammatory><Influentials><Insulin><Insulin Cell><Insulin Secreting Cell><Insulin-Dependent Diabetes Mellitus><Intervention><Intracellular Communication and Signaling><Investigators><Juvenile-Onset Diabetes Mellitus><K-Awards><K-Series Research Career Programs><Ketosis-Prone Diabetes Mellitus><LYP gene><LYP protein><Link><Lymphoid Phosphatase><MGC9013><MGC9365><MHC Class II><MHC Class II Genes><Measures><Mentors><Metabolic><Metabolic Pathway><Metabolism and Endocrinology><Mission><MoAb HuM291><Modeling><Modern Man><Molecular><Molecular Biology><Molecular Immunology><Monitor><Monoclonal Antibody HuM291><NIDDK><NIH><NOD Mouse><NOR Mouse><National Institute of Diabetes and Digestive and Kidney Diseases><National Institutes of Health><Nature><Network Analysis><Non obese><Non-Obese Diabetes Resistant mouse><Non-Obese Diabetic Mice><Non-Receptor Type 22 Protein Tyrosine Phosphatase><Non-Receptor Type 8 Protein Tyrosine Phosphatase><Nonobese><Nonobese Diabetes Resistant mouse><Nonobese Diabetic Mouse><Novolin R><Outcome><PEP gene><PEP protein><PTPN22><PTPN22 gene><PTPN8><Participant><Pathogenicity><Pathway Analysis><Pathway interactions><Pediatrics><Pest-Domain Phosphatase><Phenotype><Physicians><Play><Preclinical data><Predisposition gene><Preventative intervention><Prevention><Protein Biosynthesis><Regular Insulin><Regulation><Regulator Genes><Research><Research Career Program><Research Personnel><Researchers><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Risk><Risk-associated variant><Role><Scientist><Secondary to><Shapes><Sickness Cost><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><Sudden-Onset Diabetes Mellitus><Susceptibility Gene><T-Cells><T-Lymphocyte><T1 DM><T1 diabetes><T1D><T1DM><TCGFR><TNF-Related Apoptosis Inducing Ligand Receptor 1><TNF-related apoptosis-inducing ligand receptor 1><TNFRSF10A><TNFRSF10A gene><TNFRSF5><TNFRSF5 gene><TRAIL Receptor 1><TRAIL-R4><TRAILR-1><TRAILR1><TYK2><Techniques><Testing><Time><Training><Transcriptional Regulatory Elements><Translational Research><Translational Science><Tumor Necrosis Factor Receptor Superfamily Member 5 Gene><Tumor Necrosis Factor Receptor Superfamily, Member 10A><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Umbilical Cord Blood><United States National Institutes of Health><Universities><Variant><Variation><allelic variant><autoimmune antibody><autoimmune beta cell destruction><autoimmune condition><autoimmune disorder><autoimmune islet destruction><autoimmunity disease><autoreactive B cell><autoreactive antibody><beta cell autoimmunity><biological signal transduction><candidate validation><career><cell metabolism><cellular metabaolism><clinical test><clinical training><cohort><cytokine><cytotoxic T-lymphocyte antigen 4><death receptor-4><design><designing><developmental><diabetes><diabetic><diabetogenic><disease model><disease risk><disorder model><disorder risk><enthusiastic atmosphere><enthusiastic environment><experience><fetal cord blood><genetic trans acting element><genetic variant><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic variant><high risk><high risk group><high risk individual><high risk people><high risk population><immune modulation><immune regulation><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunologic reactivity control><immunological synapse><immunomodulatory><immunoregulation><immunoregulatory><insulin dependent diabetes><insulin dependent diabetes mellitus onset><insulin dependent type 1><insulin secretion><interest><intervention for prevention><islet autoantibody><islet autoimmunity><islet cell antibody><islet cell autoimmunity><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><medical college><medical schools><metabolic profile><mouse model><murine model><non-obese diabetic (NOD) mice><nonobese diabetic (NOD) mice><p50><pathway><pediatric><pediatric department><preclinical findings><preclinical information><predisposing gene><preservation><prevention intervention><preventional intervention strategy><preventive intervention><professor><programs><protein synthesis><receptor TRAIL-4><regulatory gene><research clinical testing><resistance to disease><resistant disease><resistant to disease><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><school of medicine><self reactive B cell><self reactive antibody><seroconversion><skills><social role><supportive atmosphere><supportive environment><susceptibility allele><susceptibility locus><susceptibility variant><therapeutic target><thymus derived lymphocyte><trans acting element><transcriptomics><translation research><translation strategy><translational approach><translational clinician><translational investigation><translational physician><translational strategy><tumor necrosis factor receptor superfamily member 10A><type 1 diabetes onset><type I diabetes><type one diabetes><whole genome association analysis><whole genome association study><β-cell><β-cells><βCell>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ariana Stickel

SAN DIEGO STATE UNIVERSITY, SAN DIEGO, CA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$153,990
FY 2026

Project Title

Risk Factors for Alzheimer's Disease Among Latinos: Relationships Between Cardiovascular Disease Risk, Acculturation, Small Vessel Disease, and Alzheimer's Biomarkers

Grant Number:

5K08AG075351-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Latinos/as are a large and growing segment of the United States older adult population and are at increased risk for Alzheimer’s disease and related dementias (ADRDs) compared to non-Latino/a Whites. Evidence suggests that Latinos/as are particularly susceptible to ADRD in the presen...

Research Terms

<AD and related dementia><AD biological marker><AD biomarker><AD dementia><AD pathology><AD pathway><AD related biomarker><AD related dementia><AD risk><AD risk factor><AD-associated pathways><AD-related pathways><AD-specific pathways><ADRD><Acculturation><Acquired brain injury><Address><Adoption><Aging><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's Disease and its related dementias><Alzheimer's amyloid><Alzheimer's and related dementias><Alzheimer's biomarker><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease pathology><Alzheimer's disease related biomarker><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's mechanism><Alzheimer's pathology><Alzheimer's related biomarker><Alzheimer's related pathways><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><American><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Ancillary Study><Astroprotein><Attenuated><Aβ><Biological><Biological Markers><Blood Plasma><Brain><Brain Injuries><Brain Nervous System><Caucasian male><Caucasian men><Cerebrovascular system><Chicanas><Chicanos><Clinical><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Communities><Cultural Assimilation><Data><Dementia><Development><Diabetes Mellitus><Disparities><Disparity><Disturbance in cognition><Economic Income><Economical Income><Encephalon><Enrollment><Epidemiological data><Epidemiology data><Estrogens><Ethnic Origin><Ethnicity><Face><GFA-Protein><GFAP><Gender><Glial Fibrillary Acid Protein><Glial Fibrillary Acidic Protein><Glial Intermediate Filament Protein><Goals><HCHS/SOL Study><HCHS/SOL cohort><Health Care><Healthy diet><Hispanic Community Health Study/Study of Latinos><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Impaired cognition><Incidence><Income><Individual><Intervention><Investigation><Latina Population><Latina females><Latina women><Latina/e women><Latina/x women><Latinas><Latine><Latine females><Latine women><Latino><Latino Population><Latino females><Latino group><Latino individual><Latino people><Latino women><Latinos><Latinx><Latinx females><Latinx women><Life Expectancy><Light><Link><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Magnetic Resonance Imaging><Measures><Mediating><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Memory><Mexican Americans><Microvascular Dysfunction><NMR Imaging><NMR Tomography><National Institute of Aging><National Institute on Aging><Neurocognitive><Nuclear Magnetic Resonance Imaging><Outcome><Performance><Photoradiation><Physical activity><Plasma><Plasma Serum><Population><Predisposition><Prevalence><Primary Senile Degenerative Dementia><Public Health><Racial Group><Research><Research Resources><Resources><Reticuloendothelial System, Serum, Plasma><Risk><Risk Factors><Role><Sampling><Scientist><Study of Latinos><Susceptibility><Testing><Therapeutic Estrogen><Training><United States><Woman><Zeugmatography><a beta peptide><abeta><alzheimer risk><amyloid beta><amyloid-b protein><attenuate><attenuates><balanced diet><beta amyloid fibril><bio-markers><biologic><biologic marker><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><biopsychosocial><black male><black man><black men><blood vessels in the brain><brain blood vessels><brain damage><brain vascular pathology><brain vascular pathophysiology><brain vasculature><brain-injured><cardiovascular disease risk><cardiovascular disorder risk><cardiovascular health><cerebral angiopathy><cerebral blood vessel><cerebral vascular pathology><cerebral vasculature><cerebral vasculopathy><cerebrovascular abnormality><cerebrovascular defect><cerebrovascular disease pathology><cerebrovascular pathology><cerebrovascular pathophysiology><cerebrovascular vessels><cerebrovasculature><cerebrovasculopathy><clinical care><cognitive change><cognitive dysfunction><cognitive loss><dementia risk><developmental><diabetes><disparity in health><enroll><epidemiologic data><ethnic difference><ethnic minority><ethnicity difference><faces><facial><good diet><health disparity><incomes><investigate longitudinal><later in life><later life><life span><lifespan><longitudinal investigation><longitudinal research><male><mechanisms in AD><mechanisms in Alzheimer's disease><men><microtubule bound tau><microtubule-bound tau><microvascular complications><microvascular disease><mid life><mid-life><middle age><middle aged><midlife><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><neurofilament><novel><old age><older adult><older adulthood><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><primary degenerative dementia><programs><psychosocial><racial population><racial subgroup><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><senile dementia of the Alzheimer type><sex><small vessel disease><social culture><social role><socio-cultural><sociocultural><soluble amyloid precursor protein><stem><study longitudinal><substantia alba><survey longitudinal><tau><tau Proteins><tau factor><tool><white male><white matter><white men><τ Proteins><♂>
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Ileana De Anda-Duran

TULANE UNIVERSITY OF LOUISIANA, NEW ORLEANS, LA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$152,957
FY 2026

Project Title

Genetic Predisposition to Elevated Blood Pressure and Midlife Cognitive Function: Exploring the Impact of Lifespan Risk Factors and Polygenic Risk Scores

Grant Number:

5K08AG086588-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/15/2025

End Date:

3/31/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Hypertension (HTN) is the most common preventable and treatable condition that increases the risk for dementia. However, RCTs for blood pressure (BP) control have shown that the benefits are highly variable from person to person, and others have reported null findings. Polygenic Risk Scores of eleva...

Research Terms

<AD and related dementia><AD related dementia><AD risk><AD risk factor><ADRD><Acquired brain injury><Advanced Development><Affect><African><Alzheimer risk factor><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Amentia><Architecture><Area><BP control><BP management><Black><Black race><Blood Pressure><Blood Vessels><Brain><Brain Injuries><Brain Nervous System><Brain Vascular Trauma><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cerebrovascular Trauma><Cerebrum><Childhood><Clinical><Clinical Trials><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Data><Data Set><Dementia><Disease><Disease Marker><Disorder><Disturbance in cognition><Drug Therapy><Eligibility><Eligibility Determination><Encephalon><Engineering / Architecture><European ancestry><Event><Exposure to><Future><Gene Frequency><Genetic><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Goals><Heart><Heart Vascular><Heritability><Hypertension><Impaired cognition><Individual><Individuals from minority><Individuals of minority><Inherited Predisposition><Inherited Susceptibility><Intervention><Investigators><Knowledge><Lesion><Life><Life Cycle><Life Cycle Stages><Life Style Modification><Long-term cohort><Longitudinal cohort><Low income><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mentorship><Methods><Minority Groups><Minority People><Minority Population><Minority individual><NMR Imaging><NMR Tomography><Neuropsychologies><Neuropsychology><Nuclear Magnetic Resonance Imaging><Observational Study><Onset of illness><Outcome><Participant><Pathology><Patients><Performance><Persons><Pharmacological Treatment><Pharmacotherapy><Physiologic pulse><Play><Population Heterogeneity><Predicting Risk><Predictive Value><Prevention><Prospective Studies><Protocol Screening><Pulse><Reporting><Research Personnel><Researchers><Risk><Risk Factors><Role><Rural><Structure><Syndrome><Techniques><Testing><Training><Underrepresented Ethnic Minority><Underrepresented Minority><Vascular Brain Injury><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Woman><Zeugmatography><accumulated exposure><accumulated long-term exposure><aggregate exposure><aggressive therapy><aggressive treatment><allelic frequency><alzheimer risk><blood pressure control><blood pressure elevation><blood pressure management><brain based><brain damage><brain health><brain volume><brain-injured><cardiovascular disorder><cardiovascular risk><cardiovascular risk factor><carotid intima-media thickness><cerebral><cerebral vascular injury><cerebrovascular injury><circulatory system><cognitive dysfunction><cognitive function><cognitive loss><cohort><cumulative exposure><cumulative life exposure><cumulative long-term exposure><dementia risk><disease onset><disease risk><disorder onset><disorder risk><disparity in health><diverse populations><drug intervention><drug treatment><early onset><elevated blood pressure><forecasting risk><genetic epidemiologic study><genetic epidemiology><genetic information><genetic vulnerability><genetically predisposed><genome scale><genome-wide><genomewide><health disparity><heterogeneous population><high blood pressure><high risk><high risk group><high risk individual><high risk people><high risk population><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><increase in blood pressure><increased blood pressure><late in life><late life><later in life><later life><life course><life span><life style intervention><life-course exposure><life-time risk><lifelong exposure><lifespan><lifespan exposure><lifestyle intervention><lifestyle modification><lifetime exposure><lifetime risk><malleable risk><men><mid life><mid-life><middle age><middle aged><midlife><modifiable risk><neural imaging><neuro-imaging><neuroimaging><neuroimaging biomarker><neuroimaging marker><neurological imaging><neuropathologic><neuropathological><neuropathology><neuropsychologic><observational research study><observational survey><pediatric><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><polygenetic risk scores><polygenic risk score><population diversity><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predicts risk><prospective research study><prospective survey><racial diversity><racially diverse><randomized, clinical trials><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><risk prediction><risk predictions><risk stratification><skills><social role><statistics><stratify risk><substantia alba><totality of exposures><trait><under-representation of minorities><under-represented minority><underrepresentation of minorities><vascular><white matter>
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Daniel Cater

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$121,854
FY 2026

Project Title

In-vivo and Ex-vivo Analysis of Tissue S-nitrosothiols in Sepsis

Grant Number:

1K08HL179468-01A1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Each year there is an estimated eight million deaths globally that are attributed to sepsis. Sepsis is one of the leading causes of death in the pediatric population. When children die it is often from refractory shock and development of multi-organ failure. A key driver of this refr...

Research Terms

<0-11 years old><21+ years old><Admission><Admission activity><Adult><Adult Human><Award><Bioinformatics><Biology><Blood><Blood Plasma><Blood Platelets><Blood Reticuloendothelial System><Blood Vessels><Body Tissues><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cause of Death><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cessation of life><Characteristics><Chemicals><Child><Child Youth><Childhood><Children (0-21)><Circulatory Collapse><Clinical><Clinical Data><Data><Death><Development><Development Plans><Development and Research><Device or Instrument Development><Devices><Disease><Disorder><Dysfunction><Education><Educational aspects><Endothelial Cells><Endothelium><Foundations><Functional disorder><Funding><Goals><Human><Immune><Immunes><Intervention><Intracellular Communication and Signaling><Investigators><K-Awards><K-Series Research Career Programs><Link><MOF syndrome><Marrow platelet><Measurement><Measures><Mentors><Mice><Mice Mammals><Modeling><Modern Man><Monitor><Multiple Organ Dysfunction Syndrome><Multiple Organ Failure><Murine><Mus><NHLBI><National Heart, Lung, and Blood Institute><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Nitrogen Oxides><Outcome><Pathologic><Pathway interactions><Peripheral><Photolyses><Physicians><Physiologic><Physiological><Physiology><Physiopathology><Plasma><Plasma Serum><Platelets><Population><Prospective cohort><Proteins><Proteomics><R & D><R&D><R-Series Research Projects><R01 Mechanism><R01 Program><Refractory><Research><Research Career Program><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Technics><Research Techniques><Researchers><Reticuloendothelial System, Serum, Plasma><Role><S-Nitrosothiols><Sampling><Scientist><Sepsis><Severity of illness><Shock><Signal Transduction><Signal Transduction Systems><Signaling><Testing><Thrombocytes><Time><Tissues><Vascular Diseases><Vascular Disorder><Vascular resistance><Work><adulthood><adverse consequence><adverse outcome><antisepsis treatment><biological signal transduction><blood vessel disorder><career><career development><child patients><children with sepsis><circulatory shock><compound repositioning><compound repurposing><design><designing><developmental><device development><differential expression><differentially expressed><disease severity><drug repositioning><drug repurposing><extracellular vesicles><in vivo><individuals with sepsis><instrument development><kids><mortality><mouse model><multiorgan failure><multiple organ system failure><murine model><neuronal><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutic uses for existing drugs><new therapeutics><new therapy><new therapy target><new use of drug><new uses for an approved drug><new uses for existing drugs><next generation therapeutics><nitrosative stress><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><pathogen><pathophysiology><pathway><patients with sepsis><pediatric><pediatric patients><pediatric sepsis><pediatric septic><people with sepsis><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><pharmacological repurposing><photolysis><point of care><predict clinical outcome><programs><repositioning approved drugs><repositioning existing drugs><repurpose approved drugs><repurpose approved medication><repurpose approved therapeutic><repurpose existing drugs><repurpose existing medication><repurpose existing medicine><repurpose existing therapeutics><repurpose existing therapies><repurpose medicine><repurposing a drug><repurposing agent><repurposing candidates><repurposing established drugs><repurposing established medication><repurposing existing pharmacological agents><repurposing medication><repurposing of already existing drugs><repurposing pharmaceuticals><research and development><risk stratification><sepsis care><sepsis groups><sepsis in children><sepsis interventions><sepsis management><sepsis patients><sepsis population><sepsis subjects><sepsis therapeutics><sepsis therapy><sepsis treatment><septic children><septic group><septic individuals><septic patients><septic people><septic population><septic subject><septic therapy><septic treatment><shocks><skills><social role><stratify risk><subjects with sepsis><therapeutic repositioning><therapeutic repurposing><therapeutic target><therapeutically effective><transcriptional differences><treat sepsis><vascular><vascular dysfunction><vasculopathy><youngster>
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Kevin Young Xu

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$75,600
FY 2026

Project Title

Using Big Data to Optimize Treatment of Opioid Use Disorder in Pregnancy

Grant Number:

3K08DA061258-02S1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2024

End Date:

7/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY I am an early career investigator in the fields of pharmacoepidemiology, population health, and addiction psychiatry. My overarching career goal is to become an independently funded researcher dedicated to investigating the real- world effectiveness of addiction medications so that w...

Research Terms

<Access to Care><Adanon><Address><Affect><Althose><American><Area><Award><Big Data><BigData><Buprenorphine><Characteristics><Clinical Trials><Communities><Data><Dedications><Dolophine><Drug Prescribing><Drug Prescriptions><Drug Therapy><Drugs><Effectiveness><FDA approved><Funding><Future><Geography><Gestation><Goals><Health Services Accessibility><Individual><Intervention><Investigators><Link><Literature><Location><Medicaid><Medication><Mentorship><Methadone><Methadose><Methods><Modeling><NIDA><Nalorex><Naltrexone><National Institute of Drug Abuse><National Institute on Drug Abuse><Nemexin><Overdose><Overdose reduction><Patients><Pharmaceutical Epidemiology><Pharmaceutical Preparations><Pharmacoepidemiology><Pharmacological Treatment><Pharmacotherapy><Policy Maker><Population><Population Research><Population-based research><Population-level research><Pregnancy><Psychiatry><ReVia><Research><Research Personnel><Researchers><Risk><Rural><Training><Treatment outcome><United States><Vivitrol><Work><access to health services><access to services><access to treatment><accessibility to health services><addiction><addictive disorder><availability of services><care access><career><career development><community factor><community-level factor><comparative effectiveness><comparative effectiveness study><comparative safety><develop therapy><drug abuse prevention><drug addiction prevention><drug epidemiology><drug intervention><drug treatment><drug use prevention><drug/agent><experience><health determinants><health service access><health services availability><improved><interest><intervention development><investigate population><medication prescription><novel><opiate crisis><opiate use disorder><opioid crisis><opioid epidemic><opioid use disorder><pharmaceutical intervention><pharmacoepidemiologic><pharmacoepidemiological><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><population based><population health><population investigation><population level investigation><population specific research><pregnant><prescribed medication><prevent drug abuse><prevent drug addiction><prevent drug use><reduce overdose><reduction in overdose><research study><service availability><studies of populations><study of the population><study population><survey population><therapy development><therapy optimization><treatment access><treatment development><treatment optimization>
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Suky Martinez

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$75,600
FY 2026

Project Title

Natural Language Processing Phenotyping of Spirituality and Resilience Among Individuals with Opioid Use Disorder

Grant Number:

3K08DA058057-02S1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2026

End Date:

6/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Despite vast economic investments to mitigate the harms of opioid use disorder (OUD), the prevalence of the disorder remains high in addition to an estimated 80,000 Americans dying from opioid-related overdoses yearly. Given the significant heterogeneity across multiple dimensions of...

Research Terms

<0-11 years old><AI Augmented><AI assisted><AI based method><AI driven><AI enhanced><AI integrated><AI powered><Administrative Supplement><Affective><American><Artificial Intelligence enhanced><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Award><Behavior><Behavioral><Birth><Blood Pressure><Cardiac Chronotropism><Causality><Cessation of life><Child><Child Youth><Children (0-21)><Cognitive><Computer Models><Computerized Models><DSM-5><DSM-V><DSM5><Data><Death><Decision Making><Development><Diagnostic and Statistical Manual of Mental Disorders, 5th edition><Diagnostic and Statistical Manual of Mental Disorders-V><Dimensions><Disease><Disorder><Drugs><Economics><Electrodermal Response><Emotional><Emotions><Etiology><Event><Fathers><Force of Gravity><Funding><Future><Galvanic Skin Response><Goals><Grant><Gravities><Heart Rate><Heterogeneity><Human><Individual><Infrastructure><Intervention><Interview><Investigation><Investments><Laboratories><Laboratory Procedures><Life><Linguistic><Linguistics><Manuscripts><Measurement><Measures><Medication><Mentors><Methodology><Methods><Modeling><Modern Man><Natural Language Processing><Opiates><Opioid><Out-patients><Outcome><Outpatients><Parents><Participant><Parturition><Patient Self-Report><Pharmaceutical Preparations><Phenotype><Physiologic><Physiological><Prevalence><Proxy><Psychogalvanic Reflex><Psychologic Stress><Psychological Stress><Randomized><Reproducibility><Research><Research Design><Role><Scientist><Self Administered><Self Administration><Self-Report><Skin Electric Conductance><Spirituality><Statistical Methods><Stress><Stress Tests><Structure><Study Type><Task Performances><Testing><Training><Validation><acute stress><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence driven><artificial intelligence integrated><artificial intelligence method><artificial intelligence powered><behavior measurement><behavioral measure><behavioral measurement><biological adaptation to stress><career><causation><cohort><computational modeling><computational models><computer based models><computerized modeling><craving><data integration><design><designing><developmental><disease causation><drug/agent><economic><enhanced with AI><enhanced with Artificial Intelligence><experience><flexibility><flexible><heart rate variability><improved><indexing><indicators of resilience><insight><kids><marker of biological resilience><markers underlying resilience><natural language understanding><novel><opiate consumption><opiate drug use><opiate intake><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><parent><participant interview><perceived stress><perception of stress><phenotypic data><primary outcome><psychobiologic><psychobiological><psychologic><psychological><randomisation><randomization><randomly assigned><reactioncrisis><recruit><resilience><resilience biomarker><resilience marker><resilient><self-reported stress><signatures of resilience><skills><skin conductance><social role><statistic methods><stress perception><stress reactivity><stress response><stressreaction><study design><theories><timeline><translational impact><validations><youngster>
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Devin Banks

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$75,584
FY 2026

Project Title

An Integrated Geospatial and Community-based Model to Prevent Opioid Overdose among Black Americans

Grant Number:

3K08DA058080-04S1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

“Opioid overdose death (OOD) rates among Black Americans have increased unabated since 2015, outpacing national averages at a rate of two to one. Health disparities in the growth rate of OOD have been documented in at least 23 states, including Missouri, which has second highest rate of OOD among Bl...

Research Terms

<Access to Care><Actiq><Address><Affect><Area><Behavioral><Black><Black American><Black Populations><Black group><Black individual><Black people><Black race><Blacks><Characteristics><Cities><Clinical Investigator><Communities><Community Health><Community Health Aides><Community based prevention><Coroner><Country><Data><Death Rate><Decision Analysis><Decrease health disparities><Deterioration><Development><Development Plans><Disparities><Disparity><Duragesic><Ecological impact><Ensure><Environment><Environmental Impact><Evidence based treatment><Face><Feedback><Fentanest><Fentanyl><Fentyl><Future><Generalized Growth><Geographic Information Systems><Geography><Goals><Growth><Health><Health Care Providers><Health Personnel><Health Services Accessibility><Health disparity mitigation><Health disparity reduction><Intervention><Interview><Low income><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Lower health disparities><Maps><Methods><Missouri><Mitigate health disparities><Modeling><Morbidity><Neighborhoods><Opiates><Opioid><Outcome><Overdose reversal><Phentanyl><Policies><Policy Maker><Population><Recovery><Reduce health disparities><Research><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Risk><Scientist><Structure><Substance Use Disorder><Technology><Tissue Growth><Training><Trust><United States><Universities><Washington><access disparities><access to health services><access to services><access to treatment><accessibility disparities><accessibility to health services><addiction><addictive disorder><availability of services><care access><career><career development><community advisory board><community advisory committee><community advisory panel><community based participatory research><community engagement><community health worker><community intervention><community led research><community level intervention><community participatory research><community partnered participatory research><community-based health><community-based intervention><density><deprivation><design><designing><developmental><digital><digital health><digital tool><digital toolkit><disparities in access><disparity in health><distribute naloxone><effectiveness testing><engagement with communities><experience><faces><facial><geospatial information system><health care personnel><health care worker><health determinants><health disparity><health provider><health service access><health services availability><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><high risk><high risk group><high risk individual><high risk people><high risk population><implementation science><improved><indexing><inequality in access><inequity in access><inequity in accessibility><life span><lifespan><mHealth therapeutic><mHealth therapy><mHealth treatment><manufacture><medical care providers><medical personnel><member><mhealth interventions><mobile health intervention><mobile health therapeutic><mobile health therapy><mobile health treatment><mortality><mortality rate><naloxone availability><naloxone dispensary><naloxone dispensation><naloxone dispensing><naloxone distribution><naloxone provision><ontogeny><opiate consumption><opiate crisis><opiate deaths><opiate drug use><opiate intake><opiate mortality><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid crisis><opioid deaths><opioid drug overdose><opioid drug use><opioid epidemic><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid mortality><opioid overdose><opioid overdose death><opioid poisoning><opioid related death><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><outreach><overdose death><overdose education><overdose fatalities><overdose prevention><overdose risk><participatory action research><peer><person centered><prevent><preventing><provide naloxone><psychoeducation><response><reverse overdose><service availability><software systems><substance use><substance use and disorder><substance use treatment><substance using><technology platform><technology system><tool><training opportunity><treatment access><treatment provider><treatment strategy>
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Veli Kemal Topkara

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$527,982
FY 2025

Project Title

Role of RNA helicase Ddx5 in pathological cardiac remodeling

Grant Number:

5R01HL170132-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/15/2024

End Date:

5/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract This new R01 proposal explores novel mechanisms underlying RNA regulation in heart failure (HF), a major global health concern with high morbidity and mortality. The PI is an advanced HF cardiologist, who studies transcriptional regulation in HF and myocardial recovery. Based on data genera...

Research Terms

<ASCVD><Adeno-Associated Viruses><Affect><Alternate Splicing><Alternative RNA Splicing><Alternative Splicing><American><Assay><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Attenuated><Autoregulation><Binding><Bioassay><Biogenesis><Biological><Biological Assay><Body Tissues><Calcium><Cancers><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiomyopathies><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chronic><Clinical Investigator Award><Co-Immunoprecipitations><Complex><Congestive Cardiomyopathy><DNA Helicases><DNA Therapy><DNA Unwinding Proteins><DNA unwinding enzyme><Data><Defect><Dependoparvovirus><Dependovirus><Devices><Dilated Cardiomyopathy><Disease><Disorder><Down-Regulation><Dysfunction><Dystrophin><Functional RNA><Functional disorder><Gene Transcription><Gene Transfer Clinical><Genes><Genetic Intervention><Genetic Transcription><Goals><Heart><Heart Diseases><Heart Muscle Cells><Heart failure><Heart myocyte><Heterogeneous-Nuclear Ribonucleoproteins><Homeostasis><Human><Immune Precipitation><Immunoprecipitation><In Vitro><Informofer><Injections><Injury><Intracellular Communication and Signaling><K08 Mechanism><K08 Program><KO mice><Knock-out Mice><Knockout Mice><LV remodeling><Label><Laboratories><Left Ventricular Remodeling><Luciferase Immunologic><Luciferases><Malignant Neoplasms><Malignant Tumor><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Medical><Messenger RNA><Mice><Mice Mammals><Modern Man><Molecular Interaction><Morbidity><Morbidity - disease rate><Murine><Mus><Muscle Development><Muscular Development><Myocardial><Myocardial Diseases><Myocardial Disorder><Myocardiopathies><NIH><National Institutes of Health><Non-Polyadenylated RNA><Non-sense Mediated Decay><Noncoding RNA><Nonsense-Mediated Decay><Nontranslated RNA><Null Mouse><Origin of Life><Pathogenesis><Pathologic><Patients><Phenotype><Physiologic><Physiological><Physiological Homeostasis><Physiopathology><Play><Population><Post-Transcriptional Control><Post-Transcriptional Regulation><Pre-mRNA><Protein Family><Proteins><Proteomics><RNA><RNA Expression><RNA Gene Products><RNA Helicase><RNA Processing><RNA Seq><RNA Splicing><RNA metabolism><RNA sequencing><RNA, Messenger, Precursors><RNAseq><Recovery><Regulation><Reporter><Research><Ribonucleic Acid><Ribosomes><Role><RyR2><Sarcomeres><Signal Transduction><Signal Transduction Systems><Signaling><Skeletal Muscle><Splicing><Stress><Tail><Testing><Therapeutic><Tissues><Transcript><Transcription><Transcriptional Control><Transcriptional Regulation><Transgenic Organisms><Translations><United States National Institutes of Health><Untranslated RNA><Veins><Voluntary Muscle><Wild Type Mouse><adeno associated virus group><aorta constriction><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><attenuate><attenuates><biologic><biological signal transduction><cardiac failure><cardiac function><cardiac myocytes differentiated from induced pluripotent stem cell><cardiomyocyte><experiment><experimental research><experimental study><experiments><familial cardiomyopathy><function of the heart><gene repair therapy><gene therapy><gene-based therapy><genetic cardiomyopathy><genetic therapy><genomic therapy><global health><heart disorder><heart function><helicase><hereditary cardiomyopathy><hiPSC><hnRNP><hospitalization rates><human disease><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human model><iPS cell derived cardiomyocytes><iPSC derived cardiomyocytes><in vivo><induced human pluripotent stem cells><induced pluripotent stem cell derived cardiac myocytes><induced pluripotent stem cell derived cardiomyocytes><inducible pluripotent stem cell derived cardiac myocytes><inducible pluripotent stem cells derived cardiomyocytes><inherited cardiomyopathy><injuries><insight><left ventricle remodeling><mRNA><mRNA Precursor><mRNA Stability><malignancy><member><micro-dystrophin><microdystrophin><mini-dystrophin><minidystrophin><model of human><mortality><mouse model><murine model><mutant><myocardium disease><myocardium disorder><neoplasm/cancer><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><noncoding><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><overexpress><overexpression><pathophysiology><post-transcriptional gene regulation><posttranscriptional><pressure><prevent><preventing><social role><transcriptional reprogramming><transcriptome sequencing><transcriptomic sequencing><transcriptomics><transgenic><translation><vector><virtual><wildtype mouse>
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Efren Flores

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 52/100
Training-friendly
Solid budget
Active award
Career award
$280,777
FY 2026

Project Title

Health Opportunities & Promoters to Enhance Screening for Lung Cancer (Hopes for Lung Cancer)

Grant Number:

5K08CA270430-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/3/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Candidate: This K08 Mentored Clinical Scientist Research Career Development Award describes Efrén J. Flores, MD, as a candidate well-positioned to complete the proposed training objectives and research aims. Dr. Flores’ background as a physician-scientist with experience in lung cancer screening (LC...

Research Terms

<Access to Care><Address><Area><Award><Awareness><Cancer Cause><Cancer Etiology><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Clinic><Clinical><Collaborations><Communities><Complex><Data><Dedications><Development Plans><Diagnosis><Disclosure><Documentation><E-Mail><Early Diagnosis><Education><Education and Outreach><Education for Intervention><Educational Intervention><Educational aspects><Electronic Health Record><Electronic Mail><Elements><Eligibility><Eligibility Determination><Email><Environment><Evidence based intervention><Fear><Focus Groups><Foundations><Fright><Guidelines><Health><Health Services Accessibility><Hispanic><Hospitals><Individual><Information Disclosure><Institution><Instruction Intervention><Instruction and Outreach><Insurance Coverage><Insurance Status><Intervention><Investigators><K-Awards><K-Series Research Career Programs><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><Leadership><Literature><Malignant Tumor of the Lung><Malignant neoplasm of lung><Measurable><Mental Health><Mental Hygiene><Mentors><Mentorship><Methods><Modality><Modeling><NIH><National Institutes of Health><Outcome><Participant><Patients><Physicians><Population><Position><Positioning Attribute><Protocol Screening><Provider><Psychological Health><Publishing><Pulmonary Cancer><Pulmonary malignant Neoplasm><Research><Research Career Program><Research Personnel><Research Resources><Researchers><Resources><Role><Schedule><Scientist><Smoke><Smoking History><Smoking Status><Survey Instrument><Surveys><Text Messaging><Theoretic Models><Theoretical model><Training><Training Intervention><Training and Outreach><Tutoring and Outreach><U.S. Preventative Services Task Force><U.S. Preventative Task Force><U.S. Preventive Services Task Force><U.S. Preventive Task Force><US Preventative Services Task Force><US Preventative Task Force><US Preventive Health Services Task Force><US Preventive Services Task Force><US Preventive Task Force><USPSTF><United States National Institutes of Health><United States Preventative Services Task Force><United States Preventative Task Force><United States Preventive Services Task Force><United States Preventive Task Force><Work><acceptability and feasibility><access to health services><access to services><access to treatment><accessibility to health services><availability of services><care access><career><career development><cease smoking><chronic mental illness><community based design><community based participatory research><community based research><community led research><community participatory research><community partnered participatory research><community partnership><cost><digital delivery><digital health><digital intervention><digitally deliver><early detection><electronic communication><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><evidence base><ex-smoker><experience><former smoker><health record><health service access><health services availability><high risk><hispanic community><improved><innovate><innovation><innovative><instructional intervention><interest><intervention delivery><intervention effect><low SES><low socio-economic position><low socio-economic status><low socioeconomic position><low socioeconomic status><lung basal segment><lung base><lung cancer><lung cancer early detection><lung cancer screening><mortality><novel><outreach><pack/year><participatory action research><patient population><patient portal><persistent mental illness><pilot trial><prevent><preventing><promoter><promotor><quit smoking><recommended screening><satisfaction><screening guidelines><screening participation><screening recommendations><screening uptake><serious mental disorder><serious mental illness><service availability><severe mental disorder><severe mental illness><short message service><smoking cessation><sms messaging><social role><stop smoking><texting><treatment access><trial enrollment>
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Neil Avadhoot Nadkarni

STATE UNIVERSITY NEW YORK STONY BROOK, STONY BROOK, NY

Good lead · 52/100
Training-friendly
Solid budget
Active award
Career award
$276,085
FY 2026

Project Title

Defining the Spatiotemporal Underpinnings of Neutrophil Recruitment, Microvascular Flow, and Oxygenation in Ischemic Stroke

Grant Number:

5K08NS121597-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary: While mechanical thrombectomy has advanced the treatment of large vessel occlusion (LVO) stroke, over 50% of patients still suffer from significant disability or death. Ischemia/reperfusion injury (I/RI), the result of restoring blood flow to deeply ischemic tissue, accelerates recr...

Research Terms

<ASCVD><Acceleration><Address><Adhesion Molecule><Adhesions><Antibodies><Apoplexy><Area><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Autopsy><Beds><Biology><Blocking Antibodies><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood Pressure><Blood Vessels><Blood flow><Blood leukocyte><Body Tissues><Brain><Brain Hypoxia><Brain Infarction><Brain Nervous System><Brain Vascular><Brain Vascular Accident><Brain region><CD31 Antigens><Cancer Biology><Cell Adhesion Molecule Gene><Cell Adhesion Molecules><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cerebrovascular system><Cessation of life><Clinical><Clinical Research><Clinical Study><Clinical Trials><Confocal Microscopy><Cortical vasculature><Data><Death><Disease><Disorder><Encephalon><EndoCAM><Endothelium><Environmental sludge><Extravasation><Feedback><Goals><Heterogeneity><Histopathology><Hour><Human><Imaging Procedures><Imaging Technics><Imaging Techniques><Impairment><In Situ><Infarction><Infiltration><Inflammation><Inflammatory Infiltrate><Invaded><Investigation><Ischemia><Ischemia-Reperfusion Injury><Ischemic Penumbra><Ischemic Stroke><Knowledge><Leakage><Lesion><Leukocytes><Leukocytes Reticuloendothelial System><Link><Location><Lytotoxicity><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Marrow Neutrophil><Marrow leukocyte><Measures><Mechanics><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mentorship><Mice><Mice Mammals><Microcirculation><Microscopy><Middle Cerebral Artery Occlusion><Modern Man><Molecular><Murine><Mus><NMR Imaging><NMR Tomography><Neurologic outcome><Neurological outcome><Neutrophil Infiltration><Neutrophil Recruitment><Neutrophilic Granulocyte><Neutrophilic Infiltrate><Neutrophilic Leukocyte><Nuclear Magnetic Resonance Imaging><O element><O2 element><OCT angiography><OCTA><Obstruction><Outcome><Oxygen><PECAM-1><Pathologic><Pathology><Patients><Pattern><Perfusion><Physiologic><Physiological><Physiology><Platelet Endothelial Cell Adhesion Molecule><Platelet Endothelial Cell Adhesion Molecule-1><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Position><Positioning Attribute><Property><Reperfusion Damage><Reperfusion Injury><Reperfusion Therapy><Research><Resolution><Risk><Sludges><Spillage><Stroke><Surface><Techniques><Testing><Therapeutic><Therapeutic Index><Thrombectomy><Time><Tissues><Toxic effect><Toxicities><Transgenic Mice><Visible Light><Visible Light Radiation><Visible Radiation><White Blood Cells><White Cell><Zeugmatography><after stroke><animal imaging><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><blood vessels in the brain><brain attack><brain blood vessels><brain infarct><brain microvasculature><brain microvessels><brain vasculature><cell adhesion protein><cerebral blood vessel><cerebral microvasculature><cerebral microvessels><cerebral vascular><cerebral vascular accident><cerebral vasculature><cerebro-vascular><cerebrovascular><cerebrovascular accident><cerebrovascular vessels><cerebrovasculature><cortical blood vessels><cortical microvascular><cortical microvessels><cortical vascular><cortical vessels><cytotoxicity><disability><improved><in vivo><infarct><insight><mechanic><mechanical><meter><migration><mouse model><multi-modality><multidisciplinary><multimodality><murine model><necropsy><neural inflammation><neuroinflammation><neuroinflammatory><neutrophil><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><optical coherence tomography angiography><post stroke><postcapillary venule><postmortem><poststroke><pre-clinical><pre-clinical study><preclinical><preclinical study><programs><recruit><reperfusion><resolutions><response><spatial and temporal><spatial temporal><spatiotemporal><stroke model><stroke outcome><stroke patient><stroke therapy><stroke treatment><stroked><strokes><success><treating stroke><vascular><white blood cell><white blood corpuscle>
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Rebecca DeBoer

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 52/100
Training-friendly
Solid budget
Active award
Career award
$267,826
FY 2026

Project Title

Validation of Quality Measures for Patient-Centered Cancer Communication in Rwanda

Grant Number:

5K08CA279874-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/13/2024

End Date:

1/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT The burden of cancer is rising in Africa and mortality rates are high. A majority (70-80%) of patients present at advanced stages, and cancer care incurs substantial financial costs for families and healthcare systems. Even for potentially curable patients, effective treatme...

Research Terms

<Active Learning><Address><Adherence><Advocate><Africa><African><Award><Belief><Bioethics><Biomedical Ethics><Budgets><Cancer Burden><Cancer Center><Cancer Treatment><Cancers><Caring><Clinical><Cluster randomization trial><Cluster randomized trial><Communication><Communication Research><Cooperative Learning><Country><Death Rate><Decision Making><Dedications><Distress><Education for Intervention><Educational Intervention><Emotional><Equilibrium><Equity><Experiential Learning><Family><Financial cost><Future><Goals><Health Care Systems><Hospitals><Instruction Intervention><Intervention><Intervention Trial><Interventional trial><Interview><Investigators><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Measures><Mentors><Modification><Morale><National Cancer Burden><Oncology><Oncology Cancer><Outcome><Patient Care><Patient Care Delivery><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Patient-Centered Care><Patients><Personal Satisfaction><Position><Positioning Attribute><Process><Program Evaluation><Property><Psychometrics><QOC><QOL><Quality of Care><Quality of life><Randomization trial><Research><Research Personnel><Research Resources><Researchers><Resources><Ruanda><Rwanda><Scientist><Structure><Survey Instrument><Surveys><Testing><Training><Training Intervention><Treatment outcome><Validation><Validity and Reliability><Work><anti-cancer therapy><balance><balance function><cancer care><cancer therapy><cancer-directed therapy><care for patients><care of patients><care resource use><care resource utilization><career><career development><caring for patients><clinician communication><cognitive interview><communicate to clinicians><communicate to providers><communicate with clinicians><communicate with doctors><communicate with providers><cost><design><designing><doctor communication><effective therapy><effective treatment><empowerment><field based data><field learning><field study><field test><health care resource use><health care resource utilization><implementation process><implementation research><implementation science><implementation strategy><improved><individual patient><instructional intervention><malignancy><monetary cost><mortality rate><multidisciplinary><neoplasm/cancer><oncology program><patient centered><patient oriented><pilot trial><programs><provider communication><randomized trial><response><skills training><strategies for implementation><therapy optimization><treatment adherence><treatment compliance><treatment optimization><trial design><validations><well-being><wellbeing>
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Erica Carmen Kaye

ST. JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN

Good lead · 52/100
Training-friendly
Solid budget
Active award
Career award
$252,084
FY 2026

Project Title

IMPROVING PROGNOSTIC COMMUNICATION IN PEDIATRIC CANCER

Grant Number:

5K08CA266935-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2022

End Date:

11/30/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT My career goal is to develop an independent research program focused on improving communication for children with advancing cancer and their families. When parents understand prognosis, children with advancing cancer are more likely to receive palliative care and interventio...

Research Terms

<0-11 years old><12 year old><12 years of age><Advanced Cancer><Advanced Malignant Neoplasm><Award><Bereavement><Cancer Patient><Cancers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Child><Child Care><Child Youth><Childhood Cancers><Children (0-21)><Clinical><Clinical Investigator><Clinical Research><Clinical Study><Clinical Treatment><Clinical Trials Design><Communication><Communication Research><Concept Formation><Data><Data Analyses><Data Analysis><Decision Making><Dedications><Development Plans><Diagnosis><Disclosure><Distress><Documentation><Evolution><Family><Future><Goals><Information Disclosure><Intervention><Intervention Studies><Interview><Investigation><Investigators><K-Awards><K-Series Research Career Programs><Knowledge><Learning><Longitudinal Studies><Longitudinal Surveys><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Neoplasms><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant Tumor><Malignant childhood cancer><Measures><Mentors><Mentorship><Methods><Oncologist><Palliative Care><Palliative Therapy><Palliative Treatment><Parents><Patient Preferences><Patients><Pediatric Oncologist><Pediatric Oncology><Perception><Personalized medical approach><Phase 1/2 trial><Phase I/II Trial><Phase III study><Pilot Projects><Position><Positioning Attribute><Process><Prognosis><Puericulture><Randomization trial><Randomized, Controlled Trials><Recommendation><Refractory><Reporting><Research><Research Career Program><Research Personnel><Researchers><Science><Site><Structure><Testing><Therapeutic><Time><Training><Work><acceptability and feasibility><advanced disease><advanced illness><age 12><age 12 years><anti-cancer research><arm><cancer care><cancer in a child><cancer in children><cancer research><career><career development><child with cancer><childhood malignancy><clinical intervention><clinical therapy><cognitive assessment><cognitive testing><cohort><comfort care><communication behavior><conceptual processes><data interpretation><design><designing><dissemination trial><evidence base><experience><feasibility testing><improved><individualized approach><intervention design><intervention research><interventional research><interventional study><interventions research><kids><long-term study><longitudinal outcome studies><longitudinal research study><malignancy><member><neoplasm/cancer><palliative intervention><parent><parenting education intervention><parenting education programs><parenting intervention><parenting program><parenting skill training><parenting training><pediatric cancer><pediatric malignancy><personalized approach><phase 3 study><pilot study><pilot test><post intervention><precision approach><preference><preservation><primary outcome><prognostic><prognostication><programs><randomized control trial><randomized trial><secondary outcome><skills><stakeholder insights><stakeholder perspectives><tailored approach><therapy design><tool><treatment design><trial enrollment><trial regimen><trial treatment><twelve year old><twelve years of age><usability><user centered design><youngster>
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HEATHER T. KEENAN

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Good lead · 48/100
Above-average budget
Recent
Active award
Career award
$846,375
FY 2026

Project Title

Pediatric Critical Care and Trauma Scientist Development Program (PCCTSDP)

Grant Number:

5K12HD047349-23

Activity Code:

K12

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/23/2004

End Date:

12/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary /Abstract This is a proposal to continue the Pediatric Critical Care Trauma Scientist Development Program (PCCTSDP) as a national program to support research career development for young faculty in pediatric critical care and pediatric trauma surgery. The goal of the PCCTSDP is to in...

Research Terms

<Advisory Committees><Award><Basic Research><Basic Science><Childhood><Childhood Injury><Clinical Management><Clinical Research><Clinical Study><Committee Members><Competence><Critical Care><Critical Illness><Critically Ill><Department chair><Development Plans><Dysfunction><EXTMR><Educational workshop><Environment><Extramural><Extramural Activities><Faculty><Faculty Education><Faculty Training><Family><Financial Support><Foundations><Functional disorder><Funding><Goals><Grant><Institution><Investigators><K12><K12 Award><K12 Mechanism><K12 Program><K23 Award><K23 Mechanism><K23 Program><Mentored Clinical Scientist Development Program><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Mentors><NIH><National Institutes of Health><Phase><Physicians><Physiopathology><Program Development><Reproducibility><Research><Research Personnel><Research Support><Research Training><Researchers><Scientist><Surgeon><Task Forces><Teacher Education><Teacher Educator><Teacher Preparation><Teacher Professional Development><Teacher Training><Time><Training><Translational Research><Translational Science><Trauma><United States National Institutes of Health><Work><Workshop><Writing><adolescent trauma><advisory team><career development><childhood trauma><critical injury><design><designing><devastating injury><faculty development><faculty professional development><financial aid><financial assistance><injured child><injured children><injury in children><instructor training><pathophysiology><pediatric><pediatric injury><pediatric trauma><programs><severe injury><skills><teacher development><translation research><translational investigation><trauma care><trauma in children><trauma surgery>
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Kevin M Watt

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Good lead · 48/100
Above-average budget
Recent
Active award
Career award
$846,375
FY 2026

Project Title

Pediatric Critical Care and Trauma Scientist Development Program (PCCTSDP)

Grant Number:

5K12HD047349-23

Activity Code:

K12

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/23/2004

End Date:

12/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary /Abstract This is a proposal to continue the Pediatric Critical Care Trauma Scientist Development Program (PCCTSDP) as a national program to support research career development for young faculty in pediatric critical care and pediatric trauma surgery. The goal of the PCCTSDP is to in...

Research Terms

<Advisory Committees><Award><Basic Research><Basic Science><Childhood><Childhood Injury><Clinical Management><Clinical Research><Clinical Study><Committee Members><Competence><Critical Care><Critical Illness><Critically Ill><Department chair><Development Plans><Dysfunction><EXTMR><Educational workshop><Environment><Extramural><Extramural Activities><Faculty><Faculty Education><Faculty Training><Family><Financial Support><Foundations><Functional disorder><Funding><Goals><Grant><Institution><Investigators><K12><K12 Award><K12 Mechanism><K12 Program><K23 Award><K23 Mechanism><K23 Program><Mentored Clinical Scientist Development Program><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Mentors><NIH><National Institutes of Health><Phase><Physicians><Physiopathology><Program Development><Reproducibility><Research><Research Personnel><Research Support><Research Training><Researchers><Scientist><Surgeon><Task Forces><Teacher Education><Teacher Educator><Teacher Preparation><Teacher Professional Development><Teacher Training><Time><Training><Translational Research><Translational Science><Trauma><United States National Institutes of Health><Work><Workshop><Writing><adolescent trauma><advisory team><career development><childhood trauma><critical injury><design><designing><devastating injury><faculty development><faculty professional development><financial aid><financial assistance><injured child><injured children><injury in children><instructor training><pathophysiology><pediatric><pediatric injury><pediatric trauma><programs><severe injury><skills><teacher development><translation research><translational investigation><trauma care><trauma in children><trauma surgery>
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Jefferson James Doyle

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$237,523
FY 2026

Project Title

Elucidation of the Molecular Mechanisms Driving Genetically-Induced High Myopia

Grant Number:

5K08EY033852-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT The goal of this K08 Mentored Clinical Scientist Research Career Development Award application is to provide the candidate with advanced skills needed to establish an independent research program investigating the pathogenesis and therapeutics of monogenic high myopia (HM) and inherited re...

Research Terms

<Aorta><Automobile Driving><Biochemical><Biometrics><Biometry><Biostatistics><Bone-Derived Transforming Growth Factor><CSAID-Binding Protein 1><CSAID-Binding Protein 2><CSBP2><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Causality><Cell Communication and Signaling><Cell Signaling><Ciliary Body><Clinical><Communication><Connective Tissue Diseases><Connective Tissue Disorder><Cytokine-Suppressive Antiinflammatory Drug-Binding Protein 1><Cytokine-Suppressive Antiinflammatory Drug-Binding protein 2><Data><Degenerative Myopia><Diminished Vision><Disease Progression><Doppler OCT><E2F Transcription Factor 1><E2F transcription factor 1 protein><E2F transcription factors><E2F-1><E2F-1 protein><E2F1><E2F1 gene><E2F1 protein><ERK 1><ERK1><ERK1 Kinase><Educational workshop><Electroretinography><Etiology><Extracellular Signal-Regulated Kinase 1><Eye><Eyeball><Funding><Fundus photography><Future><Gene Expression><Generalized Growth><Genetic Diseases><Goals><Growth><Hereditary><Histologic><Histologically><Human><Immunoblotting><Immunofluorescence><Immunofluorescence Immunologic><Individual><Inherited><Intracellular Communication and Signaling><K-Awards><K-Series Research Career Programs><Knowledge><Laboratories><Leadership><Leanness><Length><Low Vision><Lung><Lung Respiratory System><MAP Kinase 3><MAP kinase><MAPK14><MAPK14 Mitogen-Activated Protein Kinase><MAPK14 gene><MAPK3><MAPK3 Mitogen-Activated Protein Kinase><MAPK3 gene><Marfan Syndrome><Mediating><Mendelian disease><Mendelian disorder><Mendelian genetic disorder><Mentors><Mentorship><Mice><Mice Mammals><Milk Growth Factor><Mitogen-Activated Protein Kinase 14><Mitogen-Activated Protein Kinase 3><Mitogen-Activated Protein Kinase 3 Gene><Mitogen-Activated Protein Kinases><Modeling><Modern Man><Molecular><Murine><Mus><Muscle><Muscle Tissue><Mxi2><Myopia><Nearsightedness><OCT Tomography><Optical Coherence Tomography><P44ERK1><PBR3><PRB-Binding Protein E2F-1><PSTkinase p44mpk><Partial Sight><Pathogenesis><Pathological Myopia><Pathway interactions><Patients><Phenotype><Photoreceptor Cell><Photoreceptors><Photosensitive Cell><Pigmentary Retinopathy><Platelet Transforming Growth Factor><RBAP-1><RBBP-3><RBBP3><RBP3><Reduced Vision><Research><Research Activity><Research Career Program><Retina><Retinal Degeneration><Retinal Detachment><Retinal Dystrophy><Retinitis Pigmentosa><Retinoblastoma Binding Protein 3><Retinoblastoma-Associated Protein 1><Retinoschisis><Review Literature><Risk><Role><SAPK2A><Scientist><Sight><Signal Transduction><Signal Transduction Systems><Signaling><Stress-Activated Protein Kinase 2A><Subnormal Vision><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><Tapetoretinal Degeneration><Techniques><Testing><Therapeutic><Thinness><Tissue Growth><Training><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Vision><Visual Receptor><Visual impairment><Western Blotting><Western Immunoblotting><Workshop><Writing><autosome><biological signal transduction><bone><causation><degenerative retina diseases><disease causation><driving><efficacious therapy><efficacious treatment><electroretinogram><experience><eye fundus photography><fundus camera><genetic condition><genetic disorder><in vivo><inhibitor><loss of function mutation><meeting><meetings><monogenic disease><monogenic disorder><mouse model><murine model><muscular><near vision><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><ontogeny><optical Doppler tomography><optical coherence Doppler tomography><p38><p38 MAP Kinase><p38 MAPK Gene><p38 Mitogen Activated Protein Kinase><p38 Protein Kinase><p38 SAPK><p38-Alpha><p38Alpha><p44 MAPK><pathway><programs><protein blotting><response><responsible research conduct><retina degeneration><retina detachment><retinal degenerative><retinal degenerative diseases><rod and cone dystrophy><rod-cone dystrophy><side effect><single-gene disease><single-gene disorder><skills><social role><transcription factor E2F1><vision impairment><visual function><visually impaired>
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Wajd Al-Holou

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$233,280
FY 2026

Project Title

Defining Tumor Microenvironmental Interactions that drive THY1-Mediated Treatment Resistance in Glioblastoma

Grant Number:

5K08NS128271-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

This K08 proposal will complete Dr. Wajd Al-Holou’s training towards his long-term career goal of directing an independent research program that aims to define critical cellular interactions in the tumor microenvironment that drive treatment resistance in glioblastoma (GBM) and ultimately identify t...

Research Terms

<21+ years old><Adult><Adult Human><After Care><After-Treatment><Aftercare><Automobile Driving><Award><Binding><Bioinformatics><Biologic Models><Biological><Biological Models><Biometrics><Biometry><Biostatistics><Blood Vessels><Business-Friendly Atmosphere><CD97><CD97 gene><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancer Biology><Cancer Center><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cas nuclease technology><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Signaling><Cell Surface Receptors><Cell-to-Cell Interaction><Cells><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Data><Development><Dichloromethylene Diphosphonate><Disease><Disorder><Ensure><Exhibits><Expression Signature><Foundations><Gene Expression><Gene Expression Profile><Genomics><Glial Cell Tumors><Glial Neoplasm><Glial Tumor><Glioblastoma><Glioma><Goals><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><Grant><Heterogeneity><Human><In Vitro><In vivo analysis><Institution><Integrins><Integrins Extracellular Matrix><International><Intracellular Communication and Signaling><K-Awards><K-Series Research Career Programs><Knock-out><Knockout><Ligands><Macrophage><Mediating><Mediator><Mentors><Mentorship><Mesenchymal><Michigan><Model System><Modeling><Modern Man><Molecular><Molecular Interaction><Mφ><Neuroglial Neoplasm><Neuroglial Tumor><Oncology><Oncology Cancer><PDX model><Pathway interactions><Patient derived xenograft><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phenotype><Population><Primary Brain Neoplasms><Primary Brain Tumors><Productivity><Progenitor Cells><Proteins><Publishing><Radiation><Radioresistance><Recurrence><Recurrent><Recurrent Neoplasm><Recurrent tumor><Research><Research Career Program><Research Ethics><Resistance><Role><Sampling><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Stem Cell like><System><Temodal><Temodar><Testing><Training><Transcription Alteration><Tumor Biology><Tumor Cell><Universities><Upregulation><Work><Writing><adulthood><biologic><biological signal transduction><business-friendly environment><cancer genomics><cancer microenvironment><cancer type><career><career development><clinical database><clinical relevance><clinical training><clinically relevant><clodronate><collaborative atmosphere><collaborative environment><design><designing><developmental><driving><experiment><experimental research><experimental study><experiments><gene expression pattern><gene expression signature><glial-derived tumor><glioblastoma multiforme><improved><in vivo><in vivo Model><in vivo evaluation><in vivo testing><innovate><innovation><innovative><interactive atmosphere><interactive environment><interdisciplinary atmosphere><interdisciplinary environment><methazolastone><multiomics><multiple omics><neoplasm recurrence><neoplastic cell><neuroglia neoplasm><neuroglia tumor><neurosurgery><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapeutics><new therapy><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><next generation therapeutics><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapeutics><novel therapy><novel therapy approach><novel therapy target><oncogenomics><overexpress><overexpression><panomics><pathway><patient derived xenograft model><patient oriented outcomes><peer-group atmosphere><peer-group environment><post treatment><professor><progenitor capacity><progenitor cell gene><progenitor cell like><progenitor cell markers><progenitor gene><progenitor markers><progenitor stem cell markers><progenitor-like><programs><radiation resistance><radio resistance><resistance mechanism><resistance to therapy><resistant><resistant mechanism><resistant to therapy><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell analysis><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><spongioblastoma multiforme><standard of care><stem cell biomarkers><stem cell characteristics><stem cell genes><stem cell markers><stem cells><stem-like><stemness><success><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><temozolomide><therapeutic resistance><therapy resistant><transcriptional profile><transcriptional signature><treatment resistance><tumor><tumor microenvironment><vascular>
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Greg Sacks

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$217,288
FY 2026

Project Title

Optimizing surgical decision-making for premalignant pancreatic cysts

Grant Number:

5K08CA293277-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY AND ABSTRACT Pancreatic cysts are common lesions that are frequently detected incidentally on imaging scans. Intraductal papillary mucinous neoplasms (IPMNs), the most common of these lesions, have the potential to harbor cancer or develop into cancer over time. Treatment options inc...

Research Terms

<Abscission><Award><Benefits and Risks><Calibration><Cancer Patient><Cancerous><Cancers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cessation of life><Cognitive Discrimination><Common Neoplasm><Common Tumor><Consensus><Cyst><Data><Death><Decision Analysis><Decision Making><Decision Modeling><Development><Diagnosis><Discrimination><Education><Educational aspects><Excision><Extirpation><Face><Goals><Guidelines><Health Policy><Health Services Evaluation><Health Services Research><Heterogeneity><Hospitals><Image><Individual><Investigators><K-Awards><K-Series Research Career Programs><Knowledge><Length of Life><Lesion><Longevity><Malignant Neoplasms><Malignant Tumor><Measures><Medical Care Research><Mentors><Mentorship><Methods><Modeling><Monitor><Mucinous Neoplasm><Mucinous Tumor><Newly Diagnosed><Oncologic Surgeon><Operative Procedures><Operative Surgical Procedures><Outcome><Pancreas><Pancreas Cyst><Pancreatic><Pancreatic Cyst><Papillary><Patient Preferences><Patient risk><Patients><Persons><Position><Positioning Attribute><Predicting Risk><Program Development><Recommendation><Removal><Research><Research Career Program><Research Personnel><Researchers><Risk><Risk Estimate><Sampling Biases><Scanning><Site><Surgeon><Surgical><Surgical Interventions><Surgical Oncologist><Surgical Procedure><Surgical Removal><Surgical complication><Survey Instrument><Surveys><Techniques><Time><Training><Treatment outcome><United States><Unnecessary Surgery><Validation><adverse consequence><adverse outcome><analytical tool><cancer complication><cancer risk><cancer surgery><career development><competing risk><computer based prediction><data collected in real world><design><designing><developmental><experience><experiment><experimental research><experimental study><experiments><faces><facial><forecasting risk><health care policy><high risk><imaging><improved><individual patient><individualized clinical decision><individualized decision><innovate><innovation><innovative><insight><instrument><large data sets><large datasets><malignancy><neoplasm/cancer><operation><operations><participant enrollment><patient enrollment><personalized clinical decision><personalized data-driven decision><personalized decision><precancer><precancerous><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive modeling><predictive risk><predicts risk><preference><premalignant><real world data><resection><risk prediction><risk predictions><services research><shared decision making><support tools><surgery><surgery complication><surgery risk><surgical risk><tool><treatment choice><validations>
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Youssef A Kousa

CHILDREN'S RESEARCH INSTITUTE, WASHINGTON, DC

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$215,730
FY 2026

Project Title

Viral Neurobiology in the Prenatal Brain

Grant Number:

5K08NS119882-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/15/2022

End Date:

2/28/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT The prenatal brain is uniquely susceptible to viral infections. Such infections threaten 1 in 4 pregnancies and can cause severe neurodevelopmental disorders if not fetal demise. Different viruses lead to strikingly similar clinical outcomes due to overlapping viral neuropathology and the h...

Research Terms

<0-11 years old><Acquired brain injury><Active Follow-up><Affect><Alleles><Allelic Loss><Allelomorphs><Animals><Autophagocytosis><Award><Biologic Models><Biological Models><Board Certification><Brain><Brain Injuries><Brain Nervous System><Candidate Disease Gene><Candidate Gene><Caring><Cell Function><Cell Physiology><Cell Process><Cell Survival><Cell Viability><Cellular Function><Cellular Physiology><Cellular Process><Cerebral Palsy><Cerebrum><Child><Child Youth><Childhood><Children (0-21)><Clinical><Clinical Data><Code><Coding System><Complex><Country><Critical Care><Data><Development><Development Plans><Dizygotic Twins><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Fraternal Twins><Future Generations><Gene Expression><Genes><Genetic><Genomics><Gestation><Goals><Grant><Health><Hospitals><Human><Image><Immunoblotting><Individual><Infant><Infection><International><Internships><Investigators><Lead><Life><Life Experience><Loss of Heterozygosity><Lysosomes><Mechanistic Target of Rapamycin><Mentors><Mice><Mice Mammals><Model System><Modeling><Modern Man><Mothers><Motor><Motor Cortex><Murine><Mus><NIH><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><National Institutes of Health><Neonatal><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neural Stem Cell><Neuro-epidemiology><Neurobiology><Neurocyte><Neurodevelopmental Disability><Neurodevelopmental Disorder><Neuroepidemiology><Neurological Development Disorder><Neurologist><Neuronal Injury><Neurons><Neuropsychologies><Neuropsychology><Neurovirology><Organoids><Outcome><PI-3K/AKT><PI3K/AKT><Pathway interactions><Pb element><Population><Position><Positioning Attribute><Precision therapeutics><Predisposition><Pregnancy><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Proteins><RAFT1><RNA Seq><RNA sequencing><RNAseq><Regulation><Research><Research Infrastructure><Research Personnel><Researchers><Risk><Role><Scientist><Seasons><Secure><Seizure Disorder><Series><Study Subject><Subcellular Process><Susceptibility><System><Testing><Therapeutic Intervention><Titrations><Training><United States National Institutes of Health><Variant><Variation><Viral><Viral Burden><Viral Diseases><Viral Load><Viral Load result><Virus><Virus Diseases><Virus Replication><Western Blotting><Western Immunoblotting><Work><ZIKA><active followup><autophagy><beta-Hexosaminidase><beta-N-Acetyl-D-hexosaminidase><beta-N-Acetyl-D-hexosaminide N-acetylhexosaminohydrolase><beta-N-Acetyl-hexosaminidase><beta-n-acetylhexosaminidase><brain damage><brain-injured><career development><cerebral><clinical phenotype><critical injury><devastating injury><developmental><disability><epilepsia><epileptogenic><exome sequencing><exome-seq><follow up><follow-up><followed up><followup><global developmental delay><heavy metal Pb><heavy metal lead><hexosaminidase><humanized mice><humanized mouse><imaging><in vivo><infant infection><infected infant><intern><intervention therapy><kids><knock-down><knockdown><loss of function><loss of function mutation><mTOR><mammalian target of rapamycin><member><mouse model><murine model><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurobiological><neurodevelopment><neurodevelopmental disease><neurogenic progenitors><neurogenic stem cell><neuron injury><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuronal survival><neuropathologic><neuropathological><neuropathology><neuroprogenitor><neuropsychologic><novel><overexpress><overexpression><pandemic><pandemic disease><pathway><pediatric><post-natal development><postnatal><postnatal development><precision medicine><precision therapies><precision treatment><precision-based medicine><prenatal><prevent><preventing><progenitor and neural stem cells><protein blotting><public-private partnership><response><scRNA sequencing><scRNA-seq><severe injury><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transcriptome sequencing><transcriptomic sequencing><unborn><viral infection><viral multiplication><viral replication><virus infection><virus multiplication><virus-induced disease><youngster><β-Hexosaminidase>
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Christina Jackson

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$215,350
FY 2026

Project Title

BCAT1 targeted metabolic reprogramming in myeloid derived suppressor cells in glioblastoma

Grant Number:

1K08NS138676-01A1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2026

End Date:

1/30/2031

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract This proposal encompasses a research and training plan that will transition Dr. Jackson from a mentored role to an independent investigator. She is an Assistant Professor of Neurosurgery at the University of Pennsylvania with a background in brain tumor immunobiology. Her l...

Research Terms

<Abscission><Acceleration><Advisory Committees><Affect><Aggression><Aggressive behavior><Animal Model><Animal Models and Related Studies><Automobile Driving><Brain Neoplasia><Brain Neoplasms><Brain Tumors><Branched-Chain Amino Acids><Cancers><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Metabolic Process><Cellular Physiology><Cellular Process><Cellular biology><Checkpoint inhibitor><Clinic><Co-culture><Cocultivation><Coculture><Coculture Techniques><Critical Paths><Critical Pathways><Development><Differential Gene Expression><Dysfunction><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Excision><Extirpation><Foundations><Functional disorder><Funding><Future><Gene Expression><Generalized Growth><Generations><Genetic><Glial Cell Tumors><Glial Neoplasm><Glial Tumor><Glioblastoma><Glioma><Gln><Glutamate Receptor><Glutamates><Glutamine><Goals><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><Growth><Hypoxia><Hypoxic><Immune><Immune checkpoint inhibitor><Immune mediated therapy><Immunes><Immunobiology><Immunologically Directed Therapy><Immunophysiology><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Immunotherapy><In Vitro><Infiltration><Intermediary Metabolism><Intracellular Communication and Signaling><Investigation><Investigators><KO mice><Keto Acids><Knock-out><Knock-out Mice><Knockout><Knockout Mice><L-Glutamate><L-Glutamine><Laboratories><Malignant Neoplasms><Malignant Tumor><Manuscripts><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measures><Mediating><Mentors><Mentorship><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Methods><Modeling><Myelogenous><Myeloid><Myeloid Cells><Myeloid Progenitor><Myeloid Progenitor Cells><Myeloid Stem Cells><Myeloid-derived suppressor cells><Neuroglial Neoplasm><Neuroglial Tumor><Neurosurgeon><Null Mouse><Operative Procedures><Operative Surgical Procedures><Oxygen Deficiency><Pathway interactions><Patients><Pennsylvania><Physicians><Physiopathology><Play><Population><Position><Positioning Attribute><Pre-Clinical Model><Preclinical Models><Prognosis><Q Levoglutamide><Q. Levoglutamide><Receptor Signaling><Removal><Research><Research Personnel><Research Support><Researchers><Resistance><Role><Science><Scientist><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><Survival Rate><T-Cells><T-Lymphocyte><Task Forces><Techniques><Testing><Tissue Growth><Tissue-Specific Differential Gene Expression><Tissue-Specific Gene Expression><Training><Translating><Tumor Cell><Tumor Promotion><Universities><Upregulation><Work><advisory team><amino acid metabolism><biological signal transduction><branched amino acids><cancer progression><career><career development><cell biology><cell metabolism><cellular differentiation><cellular metabaolism><chemo-/radio-therapy><chemo-radiotherapy><chemoradiation><chemoradiation therapy><chemoradiation treatment><chemoradiotherapy><clinical relevance><clinically relevant><conditional knock-out><conditional knockout><design><designing><developmental><driving><epigenetically><exhaustion><experience><glial-derived tumor><glioblastoma multiforme><glioma cancer stem cell><glioma cancer stem like cell><glioma progenitor><glioma stem cells><glioma stem like cell><glutamatergic><high dimensionality><immune check point inhibitor><immune microenvironment><immune suppression><immune suppressive activity><immune suppressive function><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunosuppressive activity><immunosuppressive function><immunosuppressive microenvironment><immunosuppressive myeloid cells><immunosuppressive response><immunosuppressive tumor microenvironment><improved><in vivo Model><innovate><innovation><innovative><insight><ketoacid><knockout gene><malignancy><metabolism measurement><metabolomics><metabonomics><model of animal><mouse model><murine model><myeloid precursor><myeloid stem and progenitor cell><myeloid suppressor cells><myeloid-derived suppressive cells><neoplasm progression><neoplasm/cancer><neoplastic cell><neoplastic progression><neuro-surgeon><neuroglia neoplasm><neuroglia tumor><neurosurgery><novel><ontogeny><overexpress><overexpression><pathophysiology><pathway><pre-clinical><preclinical><professor><progenitor cell proliferation><progenitor proliferation><programs><protein expression><radio-chemo-therapy><radio-chemotherapy><radiochemotherapy><resection><resistant><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><spongioblastoma multiforme><stable isotope><stem and progenitor cell proliferation><stem cell proliferation><suppressive myeloid cells><surgery><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic evaluation><therapeutic target><therapeutic testing><thymus derived lymphocyte><transamination><tumor><tumor growth><tumor immune microenvironment><tumor progression><tumor-immune system interactions><tumors in the brain>
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EMILY HEIKAMP

DANA-FARBER CANCER INST, BOSTON, MA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$215,179
FY 2026

Project Title

Epigenetic regulators define a dynamic chromatin landscape in NUP98-rearranged leukemia

Grant Number:

5K08CA279891-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary Chromosomal translocations producing oncogenic fusion proteins are common drivers of many types of cancer, including leukemia. Translocations involving the Nucleoporin 98 (NUP98) gene produce NUP98-fusion proteins and are associated with a poor prognosis in acute myeloid leukemia (A...

Research Terms

<0-11 years old><ALL1><ALL1 gene><AML - Acute Myeloid Leukemia><Acute Lymphoblastic Leukemia Protein 1><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Award><B23><Binding><Biology><C-terminal><CRISPR><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas system><CRISPR/Cas9 screen><CXXC7><Cancers><Cell Body><Cells><Cellular Expansion><Cellular Growth><Child><Child Youth><Children (0-21)><Chimera Protein><Chimeric Proteins><Chromatin><Chromosomal dislocation><Chromosomal translocation><Clinical><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats><Complex><Computational Biology><DF/HCC><Dana-Farber Cancer Institute><Data Set><Dedications><Dependence><Disease><Disorder><Down-Regulation><Drosophila Homolog of Trithorax><EC 2.1.1><Early identification><Environment><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Financial Support><Fusion Oncogene Proteins><Fusion Protein><Gene Expression><Gene Inactivation><Gene Silencing><Gene Transcription><Genes><Genetic><Genetic Models><Genetic Risk><Genetic Transcription><Genetic Translocation><Genotype><Goals><HRX><Heterogeneity><Investigators><KMT2A><L-Lysine><Laboratory Study><Leukemic Cell><Lysine><Lysine-Specific Methyltransferase 2A><MEAI><MEN1 gene><MLL fusion leukemia><MLL gene><MLL leukemia><MLL rearranged><MLL rearrangement><MLL-rearranged leukemia><MLL1><Malignant Neoplasms><Malignant Tumor><Mediating><Menin><Mentors><Mentorship><Metabolic Protein Degradation><Methods><Methyltransferase><Mice><Mice Mammals><Mixed Lineage Leukemia Gene><Mixed-Lineage Leukemia><Mixed-Lineage Leukemia Protein><Modeling><Molecular><Molecular Interaction><Multiple Endocrine Neoplasia 1><Multiple lineage leukemia 1><Murine><Mus><Myelogenous><Myeloid><Myeloid-Lymphoid Leukemia Gene><Myeloid-Lymphoid Leukemia Protein><Myeloid/Lymphoid Leukemia Gene><Myeloid/Lymphoid Or Mixed Lineage Leukemia Protein><Myeloid/Lymphoid or Mixed Lineage Leukemia Gene><NPM><NPM1><NPM1 gene><Nuclear Pore Complex Proteins><Nucleoporin Gene><Nucleoporins><Nup Protein><Oncogenic><PRC1><PRC1 Protein><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Physicians><Polycomb Repressive Complex 1><Progenitor Cells><Prognosis><Protein Turnover><Proteins><Proto Oncogene Proteins MLL><Publishing><RNA Expression><Regulatory Protein Degradation><Relapse><Reporting><Repression><Research><Research Personnel><Researchers><Resistance><Resolution><Role><Scientist><Screening Result><Specific qualifier value><Specified><Stem Cell like><System><Therapeutic><Time><Training><Transcription><Transcriptional Control><Transcriptional Regulation><Work><Zinc Finger Protein HRX><acute granulocytic leukemia><acute myeloid leukemia><cancer type><cell growth><child patients><chromatin protein><chromosome dislocation><chromosome translocation><clustered regularly interspaced short palindromic repeats screen><computer biology><epigenetically><experience><experiment><experimental research><experimental study><experiments><financial aid><financial assistance><fitness><fusion oncoprotein><high risk><histone modification><improved outcome><in vivo><inhibitor><insight><kids><leukemia><leukemogenesis><malignancy><methylase><mixed lineage leukemia 1><mutant><neoplasm/cancer><novel><patient oriented outcomes><pediatric patients><progenitor capacity><progenitor cell like><progenitor-like><programs><promoter><promotor><protein degradation><resistance to therapy><resistant><resistant to therapy><resolutions><self-renew><self-renewal><skills><small molecular inhibitor><small molecule><small molecule inhibitor><social role><stem cell characteristics><stem cells><stem-like><stemness><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic resistance><therapeutically effective><therapy resistant><transcriptional reprogramming><transcriptional silencing><transcriptomics><transmethylase><treatment resistance><youngster>
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Jordina Rincon Torroella

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$214,101
FY 2026

Project Title

MRI-guided focused ultrasound to enhance ME3BP7 delivery as a novel therapy for Glioblastoma

Grant Number:

1K08NS140637-01A1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/6/2026

End Date:

2/28/2031

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary I am an Assistant Professor of Neurosurgery at Johns Hopkins, and my clinical practice focuses on brain tumors. I am applying for a mentored surgeon-scientist research career development award to gain advanced training in molecular biology, cancer metabolism, and novel drug delivery...

Research Terms

<Abnormal Assessment of Metabolism><Address><Advisory Committees><Affect><Animals><Anti-Cancer Agents><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Athymic Mice><Athymic Nude Mouse><BBB disruption><BBB permeabilization><BBB permeable><Biodistribution><Biometrics><Biometry><Biostatistics><Blood - brain barrier anatomy><Blood Serum><Blood-Brain Barrier><Brain><Brain Cancer><Brain Neoplasia><Brain Neoplasms><Brain Nervous System><Brain Tumors><CNS Nervous System><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancer Biology><Cancer Drug><Cancer Treatment><Cancers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cas nuclease technology><Cell Body><Cell Death><Cell Line><CellLine><Cells><Cellular biology><Central Nervous System><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Combined Modality Therapy><Coupled><DNA Molecular Biology><Data><Dependence><Development><Development and Research><Dose><Drug Delivery><Drug Delivery Systems><Drug Kinetics><Drug Targeting><Drugs><Education><Educational Activities><Educational aspects><Encapsulated><Encephalon><Enzyme Gene><Enzymes><Face><Focused Ultrasound><Foundations><Future><Genes><Genus Hippocampus><Glioblastoma><Glycolysis><Goals><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><Grant><Hemato-Encephalic Barrier><Heterogeneity><Image><Implant><In Vitro><Intermediary Metabolism><International><Intratumoral heterogeneity><Investigation><Investigators><K-Awards><K-Series Research Career Programs><Knowledge><Label><Laboratories><Laboratory Research><Legal patent><Lytotoxicity><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Malignant Cell><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Pancreatic Neoplasm><Malignant Tumor><Malignant Tumor of the Brain><Malignant neoplasm of brain><Malignant neoplasm of pancreas><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medication><Mentors><Mentorship><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolic Studies><Metabolism><Metabolism Studies><Mice><Mice Mammals><Microbubbles><Mitochondria><Modeling><Molecular Biology><Molecular Biology Techniques><Molecular Target><Multimodal Therapy><Multimodal Treatment><Murine><Mus><NMR Imaging><NMR Tomography><Neoplastic Disease Chemotherapeutic Agents><Neuraxis><Neurosurgeon><Nuclear Magnetic Resonance Imaging><Nude Mice><Oncology><Oncology Cancer><PDX model><PET><PET Scan><PET imaging><PETSCAN><PETT><Pancreas Cancer><Pancreatic Cancer><Patents><Pathway interactions><Patient derived xenograft><Patients><Penetration><Pharmaceutical Preparations><Pharmacokinetics><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Production><Proliferating><Pyruvate><R & D><R&D><Rad.-PET><Research><Research Career Program><Research Ethics><Research Personnel><Research Training><Researchers><Resistance><Role><Scientist><Seahorse><Serum><Sonication><Strains Cell Lines><Surgeon><System><Task Forces><Temodal><Temodar><Testing><Therapeutic><Training><Translating><Translational Research><Translational Science><Treatment Efficacy><Tumor Tissue><Tumor-Specific Treatment Agents><Validation><Work><Writing><Zeugmatography><advisory team><analog><anti-cancer drug><anti-cancer research><anti-cancer therapy><biomarker driven><blood-brain barrier disruption><blood-brain barrier permeabilization><blood-brain barrier permeable><bloodbrain barrier><bloodbrain barrier disruption><bloodbrain barrier permeabilization><bloodbrain barrier permeable><bromopyruvate><cancer cell><cancer cell metabolism><cancer metabolism><cancer research><cancer therapy><cancer-directed therapy><career><cell biology><clinical practice><clinical translation><clinically translatable><combination therapy><combined modality treatment><combined treatment><cultured cell line><cytotoxic><cytotoxicity><design><designing><developmental><drug development><drug/agent><effective therapy><effective treatment><efficacy study><experience><experiment><experimental research><experimental study><experiments><extracellular><faces><facial><glioblastoma multiforme><glucose analog><heterogeneity in tumors><imaging><immunosuppressed><improved><improved outcome><in vivo><innovate><innovation><innovative><insight><interest><intervention efficacy><intra-tumoral heterogeneity><intratumor heterogeneity><luminescence><malignancy><metabolic abnormality assessment><methazolastone><mitochondrial><multi-modal therapy><multi-modal treatment><multidisciplinary><necrocytosis><neoplasm/cancer><neuro-surgeon><neurosurgery><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><overexpress><overexpression><pancreatic cancer model><pancreatic malignancy><pancreatic tumor model><pathway><patient derived xenograft model><patient prognosis><personalized drugs><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><post-doctoral training><pre-clinical><precision drugs><preclinical><professor><research and development><resistant><skill acquisition><skill development><skills><social role><spongioblastoma multiforme><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><temozolomide><therapeutic efficacy><therapy efficacy><translation research><translational investigation><translational opportunities><translational potential><translational therapeutics><translational therapy><tumor cell metabolism><tumor growth><tumor heterogeneity><tumor metabolism><tumors in the brain><ultrasound><validations>
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Devin Banks

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$198,288
FY 2026

Project Title

An Integrated Geospatial and Community-based Model to Prevent Opioid Overdose among Black Americans

Grant Number:

5K08DA058080-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

“Opioid overdose death (OOD) rates among Black Americans have increased unabated since 2015, outpacing national averages at a rate of two to one. Health disparities in the growth rate of OOD have been documented in at least 23 states, including Missouri, which has second highest rate of OOD among Bl...

Research Terms

<Access to Care><Actiq><Address><Affect><Area><Behavioral><Black><Black American><Black Populations><Black group><Black individual><Black people><Black race><Blacks><Characteristics><Cities><Clinical Investigator><Communities><Community Health><Community Health Aides><Community based prevention><Coroner><Country><Data><Death Rate><Decision Analysis><Decrease health disparities><Deterioration><Development><Development Plans><Disparities><Disparity><Duragesic><Ecological impact><Ensure><Environment><Environmental Impact><Evidence based treatment><Face><Feedback><Fentanest><Fentanyl><Fentyl><Future><Generalized Growth><Geographic Information Systems><Geography><Goals><Growth><Health><Health Care Providers><Health Personnel><Health Services Accessibility><Health disparity mitigation><Health disparity reduction><Intervention><Interview><Low income><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Lower health disparities><Maps><Methods><Missouri><Mitigate health disparities><Modeling><Morbidity><Neighborhoods><Opiates><Opioid><Outcome><Overdose reversal><Phentanyl><Policies><Policy Maker><Population><Recovery><Reduce health disparities><Research><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Risk><Scientist><Structure><Substance Use Disorder><Technology><Tissue Growth><Training><Trust><United States><Universities><Washington><access disparities><access to health services><access to services><access to treatment><accessibility disparities><accessibility to health services><addiction><addictive disorder><availability of services><care access><career><career development><community advisory board><community advisory committee><community advisory panel><community based participatory research><community engagement><community health worker><community intervention><community led research><community level intervention><community participatory research><community partnered participatory research><community-based health><community-based intervention><density><deprivation><design><designing><developmental><digital><digital health><digital tool><digital toolkit><disparities in access><disparity in health><distribute naloxone><effectiveness testing><engagement with communities><experience><faces><facial><geospatial information system><health care personnel><health care worker><health determinants><health disparity><health provider><health service access><health services availability><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><high risk><high risk group><high risk individual><high risk people><high risk population><implementation science><improved><indexing><inequality in access><inequity in access><inequity in accessibility><life span><lifespan><mHealth therapeutic><mHealth therapy><mHealth treatment><manufacture><medical care providers><medical personnel><member><mhealth interventions><mobile health intervention><mobile health therapeutic><mobile health therapy><mobile health treatment><mortality><mortality rate><naloxone availability><naloxone dispensary><naloxone dispensation><naloxone dispensing><naloxone distribution><naloxone provision><ontogeny><opiate consumption><opiate crisis><opiate deaths><opiate drug use><opiate intake><opiate mortality><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid crisis><opioid deaths><opioid drug overdose><opioid drug use><opioid epidemic><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid mortality><opioid overdose><opioid overdose death><opioid poisoning><opioid related death><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><outreach><overdose death><overdose education><overdose fatalities><overdose prevention><overdose risk><participatory action research><peer><person centered><prevent><preventing><provide naloxone><psychoeducation><response><reverse overdose><service availability><software systems><substance use><substance use and disorder><substance use treatment><substance using><technology platform><technology system><tool><training opportunity><treatment access><treatment provider><treatment strategy>
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Priya Pal

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$197,374
FY 2026

Project Title

Understanding the mechanism of tropism specific immune restriction in HIV infection

Grant Number:

5K08AI184158-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

1 PROJECT SUMMARY/ABSTRACT 2 HIV/AIDS remains a significant public health issue, with an estimated 39 million individuals currently living with 3 HIV globally, of whom only 76% are on combination antiretroviral therapy (cART). cART suppresses, but does 4 not eliminate, HIV and is associated with ...

Research Terms

<AIDS><AIDS Virus><AIDS focused research><AIDS related research><AIDS research><AIDS science><AIDS specific research><AIDS/HIV><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><Address><Advanced HIV><Alpha-Beta-Omega Interferon Receptor-1><Antiviral Protein Alpha Type><Award><Binding><Blood Plasma><C-C CKR-5><C-C CKR-5 Gene><C-C Chemokine Receptor Type 5><C-C Chemokine Receptor Type 5 Gene><CC Chemokine Receptor 5><CC-CKR-5><CC-CKR-5 Gene><CC-CKR5><CCCKR5><CCCKR5 Gene><CCR-5><CCR-5 Gene><CCR5><CCR5 Protein><CCR5 Receptors><CCR5 gene><CD195 Antigen><CD195 Antigen Gene><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CHEMR13><CHEMR13 Gene><CKR-5><CKR-5 Gene><CKR5><CKR5 Gene><CKR5 Receptors><CMKBR5><CMKBR5 Gene><CXC-R4><CXCR-4><CXCR4><CXCR4 gene><Candidate Disease Gene><Candidate Gene><Cell Body><Cell Communication and Signaling><Cell Count><Cell Number><Cell Signaling><Cells><Chemokine (C-C Motif) Receptor 5><Chemokine (C-C) Receptor 5><Chemokine (C-C) Receptor 5 Gene><Chronic><Clinical><D2S201E><DNA mutation><Data><Dendritic Cells><Development><Development Plans><Disease><Disorder><Ensure><Evolution><FB22><Future><Genetic Change><Genetic defect><Genetic mutation><Goals><HIV><HIV Infections><HIV cure><HIV focused research><HIV functional cure><HIV individuals><HIV infected individuals><HIV infected persons><HIV intervention><HIV investigation><HIV people><HIV positive individuals><HIV positive people><HIV related research><HIV research><HIV science><HIV specific research><HIV therapeutic><HIV therapy><HIV treatment><HIV viral infection><HIV virus infection><HIV-1 Fusion Co-Receptor><HIV-1 Fusion Co-Receptor Gene><HIV-1 cure><HIV-1 functional cure><HIV-1 infection><HIV-1 intervention><HIV-1 therapeutic><HIV-1 therapy><HIV-1 treatment><HIV/AIDS><HIV/AIDS cure><HM89><HSY3RR><HuIFN-Alpha-Rec><Human><Human Immunodeficiency Virus therapy><Human Immunodeficiency Virus treatment><Human Immunodeficiency Viruses><IFN><IFNBR><IFRC><Immune><Immune Cell Activation><Immune Evasion><Immune system><Immunes><Impairment><In Vitro><In vivo analysis><Individual><Infection><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Innate Immune System><Institution><Interferon Alpha-Beta Receptor Alpha Chain><Interferon Receptor><Interferon Type I><Interferons><Intracellular Communication and Signaling><Investigation on HIV><Investigators><Knock-out><Knockout><Knowledge><LAP3><LAV-HTLV-III><LCR1><LESTR><Lymphadenopathy-Associated Virus><Macrophage><Mediating><Mentors><Mentorship><Mice><Mice Mammals><Modern Man><Molecular><Molecular Interaction><Murine><Mus><Mutation><Mφ><NPY3R><NPYR><NPYRL><NPYY3R><PLWH><PWH><Patients><Plasma><Plasma Serum><Productivity><Proteins><Public Health><Receptor Protein><Receptor Signaling><Reporting><Research><Research Personnel><Research Specimen><Researchers><Resistance development><Resistant development><Reticuloendothelial System, Serum, Plasma><Sampling><Severe HIV Disease><Signal Transduction><Signal Transduction Systems><Signaling><Specimen><Spinal Column><Spine><T4 Cells><T4 Lymphocytes><Testing><Time><Training><Transmission><Tropism><Veiled Cells><Vertebral column><Viral><Viral Diseases><Viral Envelope Proteins><Virion><Virus><Virus Diseases><Virus Particle><Virus Replication><Virus-HIV><antiretroviral therapy><antiretroviral treatment><backbone><biological signal transduction><career><career development><developing resistance><developmental><empowerment><exhaustion><experience><gene function><genome mutation><human immunodeficiency virus cure><human immunodeficiency virus infection><human immunodeficiency virus research><humanized mice><humanized mouse><identification of viruses><ifnar1 gene product><immune activation><immune evasive><improved><in vivo><in vivo evaluation><in vivo testing><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infected with HIV><infected with human immunodeficiency virus><instructor><life span><lifespan><mouse model><murine model><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><pathogen><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><pressure><receptor><reconstitute><reconstitution><research addressing HIV><research in HIV><research into HIV><research on HIV><research on human immunodeficiency virus><research study><research to address HIV><science on HIV><science to address HIV><skills><studies on HIV><success><transmission process><treat HIV><treat Human Immunodeficiency Virus><type I IFN receptor><type I interferon receptor><viral fitness><viral infection><viral multiplication><viral replication><virus envelope><virus identification><virus infection><virus multiplication><virus-induced disease>
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Daniel Seong-Joo Shin

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$194,740
FY 2026

Project Title

The Establishment of Lung Resident Self-Antigen-Specific CD4+ Tregs Following Acute Tissue injury

Grant Number:

5K08AI187736-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Self-antigen-specific T cells prevalent within the adaptive immune system pose an ever-present threat to health. Accordingly, they are heavily regulated at steady-state by mechanisms of peripheral tolerance. Infections and inflammation, however, offer an opportunity for these cells t...

Research Terms

<Acute><Acute Lung Injury><Acute Pulmonary Injury><Adaptive Immune System><Address><Adopted><Advisory Committees><Affinity><Antigen Presentation><Antigens><Autoantigens><Autoimmune><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Autologous Antigens><Autoregulation><Award><Bar Codes><Body Tissues><Boston><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Cellular biology><Children's Hospital><Class II Genes><Clinical><Development><Development Plans><Disease><Disorder><Doctor of Philosophy><FOXP3><FOXP3 gene><Forkhead Box P3><Foundations><Frequencies><Funding><Future><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Transcription><General Hospitals><Genetic Transcription><Goals><Grain><HLA Class II Genes><Health><Homeostasis><Immune memory><Immune system><Immunologic Memory><Immunological Memory><Immunology><Infection><Inflammation><Inflammatory><Injury><Interdisciplinary Research><Interdisciplinary Study><Investigators><JM2><Kinetics><Lung><Lung Diseases><Lung Inflammation><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Lung damage><MHC Class II><MHC Class II Genes><Massachusetts><Mentors><Mentorship><Mice><Mice Mammals><Monitor><Moon><Multidisciplinary Collaboration><Multidisciplinary Research><Murine><Mus><NIH><National Institutes of Health><Non-Polyadenylated RNA><Organ><Parabiosis><Pediatric Hospitals><Peptide-MHC><Peptide-Major Histocompatibility Protein Complex><Peptide/MHC Complex><Ph.D.><PhD><Phenotype><Physiological Homeostasis><Pneumonitis><Population><Population Dynamics><Population Research><Population-based research><Population-level research><Position><Positioning Attribute><Prevention><Primary Immunodeficiency><Productivity><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Inflammation><RNA><RNA Expression><RNA Gene Products><Recurrence><Recurrent><Regulatory T-Lymphocyte><Research Personnel><Researchers><Resolution><Ribonucleic Acid><Role><SCURFIN><Scientific Advances and Accomplishments><Self-Antigens><Structure of parenchyma of lung><Systems Biology><T-Cells><T-Lymphocyte><T-cell receptor repertoire><T4 Cells><T4 Lymphocytes><TCR repertoire><Task Forces><Technical Expertise><Testing><Therapeutic><Tissues><Training><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Treg><United States National Institutes of Health><Work><acquired immune system><adaptive immune response><advisory team><analyze gene expression><anamnestic reaction><antigen-specific T cells><autoimmune condition><autoimmune disorder><autoimmunity disease><barcode><career development><cell biology><congenital immune deficiency><congenital immunodeficiency><developmental><disease of the lung><disorder of the lung><experience><gene expression analysis><gene expression assay><genetic immune defect><genetic immune deficiency><genetic immunodeficiency><immunogen><improved><inborn errors in immunity><inborn errors of immunity><inborn immunodeficiency><inherited immune defect><inherited immune deficiency><inherited immunodeficiency><injuries><injury to tissue><insight><interest><investigate population><lung development><lung disorder><lung injury><mouse model><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pMHC><peripheral tolerance><population investigation><population level investigation><population specific research><prevent><preventing><primary immune defect><primary immune deficiency><programs><pulmonary damage><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><regulatory T-cells><residence><residential building><residential site><resolutions><response><restraint><scientific accomplishments><scientific advances><secondary immune response><skills training><social role><studies of populations><study of the population><study population><survey population><technical skills><therapeutic agent development><therapeutic development><thymus derived lymphocyte><tissue injury><tool><trafficking><transcriptional profiling><transcriptomics>
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Ignacio Alberto United States Portales Castillo

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$192,288
FY 2026

Project Title

Barrestin-mediated desensitization of PTH1R at the intersection of PTH and PTHrP biologic actions

Grant Number:

1K08DK146198-01

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract This proposal describes a 5-year plan for Dr. Portales-Castillo to become an independent investigator with expertise in parathyroid hormone /parathyroid hormone related peptide receptor (PTH1R) signaling in patients with skeletal dysplasias. Dr. Portales completed his clinic...

Research Terms

<1-Alpha-Hydroxylase><25-Hydroxyvitamin D3-1-Alpha-Hydroxylase><3'5'-cyclic ester of AMP><Adenosine Cyclic 3',5'-Monophosphate><Adenosine Cyclic Monophosphate><Adenosine, cyclic 3',5'-(hydrogen phosphate)><Adipocytes><Adipose Cell><Adipose tissue><Affect><Animal Model><Animal Models and Related Studies><Arrestins><Autoregulation><Award><Basic Research><Basic Science><Binding><Biological><Biological Function><Biological Process><Biology><Blood><Blood Reticuloendothelial System><Bone Tissue><CYP27B1><CYP27B1 gene><Calcium><Chondrocytes><Clinical><Cyclic AMP><Cytochrome P450, Subfamily XXVIIB, Polypeptide 1><Cytoplasmic Domain><Cytoplasmic Tail><DNA mutation><Dihydroxycholecalciferols><Dihydroxyvitamins D><Down-Regulation><Endocrine><Endocytosis><Epiphyseal Plate><Epiphysial cartilage><Epithelial Cells><Erinaceidae><Exhibits><Expression Signature><Fat Cells><Fats><Fatty Tissue><Fatty acid glycerol esters><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><Gene Expression Profile><General Hospitals><Generations><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><Growth Plate><Hedgehogs><Homeostasis><Human><Hypercalcemic Hormone of Malignancy><Impairment><In Vitro><Intermediary Metabolism><Investigators><Kidney><Kidney Urinary System><Knock-out><Knockout><Laboratories><Lead><Learning><Ligands><Lipocytes><Lipolysis><Massachusetts><Mature Lipocyte><Mature fat cell><Mediating><Mentorship><Metabolic><Metabolic Processes><Metabolism><Metaphyseal chondrodysplasia><Mice><Mice Mammals><Modern Man><Molecular Interaction><Molecular Target><Murine><Mus><Mutation><Nephrology><Nonsense Codon><Obesity><Organ><Organoids><Orphan Disease><P450C1-Alpha><PTH Like Tumor Factor><PTH gene><PTH-Like Protein><PTH-PTHrP Receptor><PTH-Related Peptide><PTH-Related Peptide Receptor><PTH-Related Protein Receptor><PTH1 receptor><PTHLP Receptor><PTHrP><PTHrP Receptor><Parathyrin><Parathyroid Hormone><Parathyroid Hormone Like Tumor Factor><Parathyroid Hormone Receptor><Parathyroid Hormone Receptor 1><Parathyroid Hormone Receptor Type I><Parathyroid Hormone-Like Hormone><Parathyroid Hormone-Like Peptide Receptor><Parathyroid Hormone-Like Protein><Parathyroid Hormone-Related Peptide><Parathyroid Hormone-Related Peptide Receptor><Pathway interactions><Patients><Pb element><Peptide Signal Sequences><Phosphorous><Phosphorus><Physicians><Physiologic Ossification><Physiological Homeostasis><Physiological Ossification><Premature Stop Codon><Production><Proliferating><Proximal Kidney Tubules><Rare Diseases><Rare Disorder><Receptor Protein><Recombinant Parathyroid Hormone-Related Protein><Renal Osteodystrophy><Research><Research Personnel><Researchers><Resistance><Retinal S-Antigen><Role><SRP receptor><Scientist><Serine/Threonine Phosphorylation><Signal Induction><Signal Pathway><Signal Peptide><Signal Sequences><Skeletal Development><Syndrome><Tail><Testing><Threonine Phosphorylation Site><Time><Training><Tumor Hypercalcemic Factor><Universities><Washington><Work><adenosine 3'5' monophosphate><adipose><adiposity><biologic><bone><cAMP><career><cartilage cell><cellular targeting><corpulence><desensitization><experiment><experimental research><experimental study><experiments><gain of function><gene expression pattern><gene expression signature><genome mutation><heavy metal Pb><heavy metal lead><hormone analog><hormone resistance><human disease><humanized mice><humanized mouse><in vivo><insight><interest><loss of function><mammary><model of animal><mouse model><murine model><mutant><normal ossification><novel><orphan disorder><ossification><paracrine><parathormone><parathyroid hormone-related protein><pathway><professor><protein signal sequence><receptor><recruit><renal><renal proximal tubule><resistant><response><restraint><signal peptide receptor><signal recognition particle receptor><single cell analysis><skeletal disease><skeletal disorder><skeletal dysplasia><skills><social role><subcutaneous><subdermal><transcriptional profile><transcriptional signature><transcriptomics><white adipose tissue><yellow adipose tissue>
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Jeffrey P Guenette

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$191,290
FY 2026

Project Title

Rapid Anatomic and Quantitative MR Imaging of the Skull Base and Face

Grant Number:

5K08EB034299-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Skull base and face imaging accounts for nearly 20% of clinical neuroradiology examinations. But clinical MRI of the skull base and face continues to rely primarily on conventional 2D T1-weighted and T2-weighted pulse sequences and fat suppression techniques. These technique...

Research Terms

<3-D><3-Dimensional><3D><Anatomic Sites><Anatomic structures><Anatomy><Artifacts><Atlases><Basicranium><Basis cranii><Biological Markers><Body Tissues><Body part><Brain><Brain Nervous System><Brain imaging><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Clinical><Clinical Protocols><Cranial Base><Cranial Nerve VII><Cranial Nerves><Data><Derivation><Derivation procedure><Development><Diagnosis><Disease><Disorder><Encephalon><Face><Facial Nerve><Facial nerve structure><Fats><Fatty acid glycerol esters><Fingerprint><Funding><Future><Goals><H+ element><HNSCC><Head and Neck Squamous Cell Carcinoma><Head and Neck Surgeon><Heart><Hospitals><Hydrogen Ions><Image><K-Awards><K-Series Research Career Programs><Laboratories><Lead><Learning><MR Imaging><MR Tomography><MRI><MRI biomarker><MRI marker><MRIs><Magnetic Resonance Imaging><Math><Mathematics><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mentors><Mentorship><Methods><Modality><Modernization><Morphologic artifacts><Motion><NIH><NMR Imaging><NMR Tomography><National Institutes of Health><Neck><Nerve><Noise><Normal Range><Normal Values><Nuclear Magnetic Resonance Imaging><Otolaryngology><Pathology><Pathway interactions><Pb element><Performance><Physicians><Physics><Physiologic pulse><Production><Property><Protocol><Protocols documentation><Protons><Pulse><Research><Research Activity><Research Career Program><Research Resources><Resolution><Resources><SCCHN><Sampling><Scanning><Scientist><Seventh Cranial Nerve><Structure><System><Techniques><Testing><Time><Tissues><Training><United States National Institutes of Health><Vendor><Visualization><Woman><Work><Zeugmatography><anatomic imaging><anatomical imaging><bio-markers><biologic marker><biomarker><brain visualization><chemo-/radio-therapy><chemo-radiotherapy><chemoradiation><chemoradiation therapy><chemoradiation treatment><chemoradiotherapy><clinical imaging><clinical relevance><clinically relevant><contrast imaging><density><design><designing><developmental><faces><facial><head and neck squamous carcinoma><head and neck squamous cell cancer><heavy metal Pb><heavy metal lead><image construction><image generation><image processing><image reconstruction><image-based method><imaging><imaging method><imaging modality><improved><in vivo><magnetic resonance imaging biomarker><magnetic resonance imaging marker><novel><otorhinolaryngology><pathway><radio-chemo-therapy><radio-chemotherapy><radiochemotherapy><rapid method><rapid technique><resolutions><response to therapy><response to treatment><skills><skull base><standard of care><therapeutic response><therapy response><three dimensional><translational study><treatment response><treatment responsiveness><tumor>
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Matthew A. Geramita

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$189,540
FY 2026

Project Title

The role of cortico-striatal circuitry in model-based decision-making

Grant Number:

5K08MH136338-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT The ability to adapt behavior to changing conditions is crucial to survival, and deficits in behavioral flexibility contribute to a number of psychiatric symptoms. Both humans and rodents have evolved a decision-making system known as model-based control (MBC) to effectively adjust behavior...

Research Terms

<Area><Assay><Award><Behavior><Behavior monitoring><Behavioral><Bilateral><Bioassay><Biological Assay><Brain><Brain Nervous System><Cognitive><Communication><Compulsive Behavior><Corpus Striatum><Corpus striatum structure><Cues><Decision Making><Disease><Disorder><Dopamine><Eating Disorders><Electrophysiology><Electrophysiology (science)><Elements><Encephalon><Environment><Frequencies><Future><GeneHomolog><Goals><Homolog><Homologous Gene><Homologue><Human><Hydroxytyramine><Impairment><Investigators><Lead><Learning><Left><Maps><Measures><Mediating><Mentors><Mentorship><Mice><Mice Mammals><Modeling><Modern Man><Monitor><Motor><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Obsessive-Compulsive Disorder><Obsessive-Compulsive Neurosis><Outcome><Pathway interactions><Pb element><Perception><Play><Position><Positioning Attribute><Probability><Process><Psychiatrist><Psychological reinforcement><Pyramidal Tracts><Reinforcement><Research><Research Personnel><Researchers><Rewards><Rodent><Rodentia><Rodents Mammals><Role><Sensory><Striate Body><Striatum><System><Testing><Time><Training><Translating><Update><Work><addiction><addictive disorder><behavioral monitoring><career><cell type><electrophysiological><flexibility><flexible><heavy metal Pb><heavy metal lead><high reward><human derived model><human derived platform><human derived system><human like model><human like platform><human like system><human model><human specific alternative><human specific model><human specific platform><human specific system><human-based alternative><human-based biological models><human-based model><human-based nonanimal models><human-based platform><human-based research><human-based system><human-based tools><human-centered model><human-centered platform><human-centered research><human-centered system><human-focused research><human-relevant alternative><human-relevant model><human-relevant platform><human-relevant system><in vivo><model of human><neural><neural circuit><neural circuitry><neural mechanism><neurocircuitry><neuromechanism><neuronal><novel><optogenetics><pathway><perceptual stimulus><physicochemical phenomena related to the senses><programs><psychiatric symptom><segregation><sensory stimulus><skills><social role><striatal><synaptic circuit><synaptic circuitry>
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Samuel Gibson Rayner

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$187,056
FY 2026

Project Title

Hemodynamic Contributions to Vascular Dysfunction in Pulmonary Arterial Hypertension

Grant Number:

5K08HL166696-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Pulmonary arterial hypertension (PAH) is a progressive and ultimately fatal disease with a median survival from diagnosis of approximately six years despite modern treatments. Up to 1 in 20,000 people are affected, and no available therapies cure or prevent this disease. PAH...

Research Terms

<Abnormal Cell><Address><Affect><Basic Research><Basic Science><Behavior><Bioinformatics><Biomedical Engineering><Blood Vessels><Blood flow><Calcium Ion Signaling><Calcium Signaling><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular biology><Cessation of life><Collagen><Communication><Complex><Coupled><Cues><Data><Death><Development><Development Plans><Diagnosis><Disease><Disorder><Dysfunction><Endothelial Cells><Engineering><Environmental Factor><Environmental Risk Factor><Exposure to><Expression Signature><Functional disorder><Future><Gene Expression Profile><Gene Transcription><Genetic Transcription><Goals><Human><Immunofluorescence><Immunofluorescence Immunologic><Individual><Intracellular Communication and Signaling><Investigation><Laboratories><Leiomyocyte><Mentorship><Methods><Microfluidic Device><Microfluidic Lab-On-A-Chip><Microfluidic Microchips><Microfluidics><Modeling><Modern Man><Modernization><Morphology><NGS Method><NGS system><Pathogenesis><Pathologic><Pathway interactions><Patients><Pattern><Persons><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Phenotype><Physicians><Physiologic><Physiological><Physiopathology><Play><Position><Positioning Attribute><Production><Proliferating><Pulmonary Artery><Pulmonary Vascular Resistance><Pulmonary artery structure><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Research><Research Proposals><Role><Scientist><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Techniques><Therapeutic><Therapeutic Intervention><Time><Training><Transcription><Translational Research><Translational Science><Vascular Diseases><Vascular Disorder><Vascular remodeling><Work><arteriole><bio-engineered><bio-engineers><bioengineering><biological engineering><biological signal transduction><blood vessel disorder><career development><cell biology><chip model><chip system><combinatorial><curative intervention><curative therapeutic><curative therapy><curative treatments><design><designing><developmental><environmental risk><gene expression pattern><gene expression signature><hemodynamics><intervention therapy><lung vascular cells><microfluidic chip><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><next gen sequencing><next generation sequencing><nextgen sequencing><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><on a chip><on chip><pathophysiology><pathway><pharmaceutical><precision medicine><precision-based medicine><pressure><prevent><preventing><programs><prototype><pulmonary><pulmonary arterial endothelial cell><pulmonary arterial hypertension><pulmonary artery endothelial cell><pulmonary artery hypertension><pulmonary vascular cells><response><right heart failure><right sided heart failure><right ventricle failure><right ventricular failure><right ventricular heart failure><scRNA sequencing><scRNA-seq><screening><screenings><shear stress><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><success><transcriptional profile><transcriptional signature><transcriptome sequencing><transcriptomic sequencing><transcriptomics><translation research><translational investigation><vascular><vascular dysfunction><vasculopathy><µfluidic>
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Emily Louise Moscato

RESEARCH INST NATIONWIDE CHILDREN'S HOSP, COLUMBUS, OH

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$185,795
FY 2026

Project Title

A digital health parent coaching intervention to improve neurodevelopmental outcomes for young childhood cancer survivors in underserved communities

Grant Number:

5K08CA290060-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY: There are almost half a million childhood cancer survivors in the United States. Over two-thirds of survivors will develop at least one late effect. Young childhood cancer survivors (YCCS; age at diagnosis <7 years) are at the highest risk for developing neurocognitive late effects,...

Research Terms

<0-11 years old><21+ years old><ASD><Academic achievement><Active Follow-up><Adult><Adult Human><Adverse Late Effects><Age><Appalachia><Appalachian><Appalachian Region><Area><Autism><Autistic Disorder><Behavioral><Behavioral trial><Brain><Brain Nervous System><CNS Tumor><CNS neoplasm><Cancers><Care Givers><Caregivers><Caring><Central Nervous System Neoplasms><Central Nervous System Tumors><Child><Child Rearing><Child Youth><Children (0-21)><Clinical><Data><Development><Diagnosis><Dose><Early Infantile Autism><Early Intervention><Education><Educational aspects><Educational process of instructing><Eligibility><Eligibility Determination><Emotional><Encephalon><Enrollment><Evidence based intervention><Family><Future><Goals><Health Care Costs><Health Care Providers><Health Costs><Health Personnel><High Prevalence><Hospital Admission><Hospitalization><Impoverished><Infantile Autism><Internet><Intervention><Intervention Strategies><Kanner's Syndrome><Late Effects><Learning><Life><Malignant Neoplasms><Malignant Tumor><Mentors><Mentorship><Methods><Mission><Modeling><NIH><National Institutes of Health><Neurocognitive><Neurologic><Neurological><Oncology><Oncology Cancer><Outcome><Parent-Child Relations><Parent-Child Relationship><Parenting><Parenting behavior><Parents><Persons><Phase><Population><Position><Positioning Attribute><Poverty><Premature Birth><Prematurely delivering><Preparedness><Preterm Birth><Preterm brain injury><Protocol Screening><Psychosocial Assessment and Care><Public Health><QOL><Quality of life><Randomized><Readiness><Research><Research Resources><Resources><Risk><Risk Factors><Rural><Schools><Scientist><Self Direction><Services><Specialty><Stress><Supportive Therapy><Supportive care><Survivors><System><Teaching><Testing><Training><United States><United States National Institutes of Health><WWW><acceptability and feasibility><active followup><adulthood><ages><arm><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><brain damage in preterm infants><brain injury in preterm infants><burden of disease><burden of illness><cancer survival><childhood cancer survivor><childrearing><classroom environment><clinical significance><clinically significant><cohort><college atmosphere><collegial atmosphere><collegiate atmosphere><community engaged participatory research><community engaged research><community partnered research><community-engaged study><community-partnered study><comparator group><comparison group><design><designing><developmental><digital health><disability><disease burden><early childhood><education atmosphere><educational atmosphere><educational environment><enroll><experience><feasibility trial><follow up><follow up assessment><follow-up><followed up><followup><followup assessment><health care personnel><health care worker><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><high risk><improved><intellectual atmosphere><internet resource><kids><learning atmosphere><learning environment><life span><lifespan><malignancy><medical care providers><medical personnel><medical specialties><mobile app><mobile application><mobile device application><neoplasm/cancer><neuroprotection><neuroprotective><on-line compendium><on-line resource><online compendium><online resource><parent><parent child interaction><parent offspring interaction><pediatric cancer survivor><premature childbirth><premature delivery><preterm delivery><prevent><preventing><programs><psychosocial><psychosocial assessment><psychosocial care><psychosocial studies><psychosocial support><randomisation><randomization><randomly assigned><school atmosphere><school climate><skills><social><training atmosphere><treatment effect><treatment provider><tumor of the central nervous system><tumors in the central nervous system><under served community><underserved community><university atmosphere><usability><videoconference><videoconferences><virtual coach><web><web resource><web tool><web-based resource><web-based tool><world wide web><youngster>
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Mona A Alotaibi

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$174,096
FY 2026

Project Title

Eicosanoid Pathways Underlying Disease Risk in Pulmonary Arterial Hypertension

Grant Number:

5K08HL166950-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT The objectives of this K08 proposal are to foster the development of critical scientific and professional skills that will allow the candidate, Dr. Mona Alotaibi, to advance toward her goal of becoming an independent investigator; and to investigate the role of metabolic dys...

Research Terms

<Animal Model><Animal Models and Related Studies><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Arachidonic Acid Cyclooxygenase><Arachidonic Acids><Cations><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Signaling><Cells><Cessation of life><Clinical><Clinical Management><Clinical Trials><Complex><Contracting Opportunities><Contracts><Cyclo-Oxygenase><Cyclooxygenase><Data><Death><Dedications><Development><Diagnosis><Disease><Disease Outcome><Disease Progression><Disorder><Doctor of Philosophy><Eicosanoids><Endothelial Cells><Endothelium><Exhibits><Experimental Designs><Experimental Models><Fatty Acid Cyclo-Oxygenase><Fostering><Future><Goals><HETE><Human><Hydroperoxide Cyclase><Hydroxyeicosatetraenoic Acids><Intermediary Metabolism><Intervention><Intracellular Communication and Signaling><Investigators><Laboratories><Laboratory Procedures><Leadership><Left><Leiomyocyte><Life><Linoleate-Oxygen Oxidoreductase><Lipids><Lipoxidase><Lipoxygenase><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measures><Mediating><Mediator><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mentors><Metabolic><Metabolic Processes><Metabolism><Methods><Modern Man><Molecular><Morbidity><NMR Imaging><NMR Tomography><Nuclear Magnetic Resonance Imaging><Outcome><PGH Synthase><PGH2 Synthetase><Pathogenesis><Pathogenicity><Pathway interactions><Patients><Personalized medical approach><Ph.D.><PhD><Phenotype><Physicians><Piezo 1><Piezo 1 ion channel><Piezo1><Play><Preclinical data><Principal Investigator><Prognostic Marker><Program Development><Property><Prostaglandin Cyclo-Oxygenase><Prostaglandin Cyclooxygenase><Prostaglandin Endoperoxide Synthetase><Prostaglandin G-H Synthase><Prostaglandin H Synthase><Prostaglandin H2 Synthetase><Prostaglandin Synthase><Prostaglandin Synthetase><Prostaglandin-Endoperoxide Synthase><Pulmonary Artery><Pulmonary Hypertension><Pulmonary artery structure><Receptor Protein><Relaxation><Research><Research Design><Research Personnel><Researchers><Role><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Study Type><Study models><Systems Biology><Techniques><Testing><Therapeutic><Therapeutic Intervention><Training><Training Programs><Transfection><Vascular remodeling><Vasodilatation><Vasodilation><Vasorelaxation><Work><Zeugmatography><biological signal transduction><career development><carotene oxidase><cell culture><cell cultures><circulating biomarkers><circulating markers><clinical translation><clinically translatable><cohort><customized therapy><customized treatment><data handling><depository><developmental><disease risk><disorder risk><endothelial dysfunction><experiment><experimental research><experimental study><experiments><hemodynamics><improved><individualized approach><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><intervention therapy><lab curriculum><lab experience><lab training><laboratory course><laboratory curriculum><laboratory experience><laboratory training><lipid mediator><lung vascular remodeling><lung vasoconstriction><metabolism measurement><metabolomics><metabonomics><model of animal><molecular biomarker><molecular marker><mortality><mouse model><murine model><novel><pathway><patient registry><patient specific therapies><patient specific treatment><personalized approach><precision approach><preclinical findings><preclinical information><prevent><preventing><prognostic><prognostic biomarker><prognostic indicator><pulmonary arterial hypertension><pulmonary artery hypertension><pulmonary vascular constriction><pulmonary vascular remodeling><pulmonary vasoconstriction><receptor><relaxing factor><repository><right heart failure><right sided heart failure><right ventricle failure><right ventricular failure><right ventricular heart failure><skills><small molecule><social role><specific biomarkers><study design><tailored approach><tailored medical treatment><tailored therapy><tailored treatment><unique treatment><vascular constriction><vasoconstriction>
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Margaret Chang

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$173,340
FY 2026

Project Title

Development of resident memory T cells in the synovium

Grant Number:

5K08AR080992-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/4/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) are chronic autoimmune diseases of the joint punctuated by periodic arthritis flares. Clinicians have long recognized that each affected person develops an individual pattern of affected joints, and that this ...

Research Terms

<3-D><3-D modeling><3-Dimensional><3D><3D modeling><AML2><Adoptive Transfer><Advisory Committees><Affect><Antibodies><Antigens><Area><Arthralgia><Arthritis><Atrophic Arthritis><Attenuated><Autoimmune Diseases><Bioinformatics><Biology><Body Tissues><Boston><CD8><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CD8B><CD8B1><CD8B1 gene><CITE sequencing><CITE-seq><CITEseq><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Lineage><Cell Signaling><Cells><Cellular Indexing of Transcriptomes and Epitopes by Sequencing><Cellular biology><Chemotactic Cytokines><Childhood><Children's Hospital><Chronic><Chronic Childhood Arthritis><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Co-culture><Cocultivation><Coculture><Coculture Techniques><Coupled><Data><Development><Differential Gene Expression><Disease><Disease remission><Disorder><Doctor of Medicine><Doctor of Philosophy><Drugs><Dysfunction><Effector Cell><Endothelial Cells><Environment><Event><Exhibits><Fatty Acids><Fibroblasts><Flare><Foundations><Functional disorder><Funding><Future><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Targeting><Gene Transcription><Genes><Genetic Transcription><Goals><Head><Homing><Homologous Chemotactic Cytokines><Hospitals><Human><Immune><Immune Cell Activation><Immunes><Immunology><Individual><Inflammation><Inflammatory><Inflammatory Arthritis><Institution><Intercrines><Interruption><Intracellular Communication and Signaling><Investigators><Joint Diseases><Joint Pain><Joints><Juvenile Chronic Arthritis><Juvenile Chronic Polyarthritis><Juvenile Rheumatoid Arthritis><Knowledge><LYT3><Laboratories><Learning><Ligands><Lymph Node Reticuloendothelial System><Lymph node proper><Lymphatic nodes><M.D.><MHC Receptor><Maintenance><Major Histocompatibility Complex Receptor><Mediating><Mediator><Medication><Membrana Synovialis Capsulae Articularis><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Memory><Mentors><Mentorship><Methods><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><NIAMS><National Institute of Arthritis, and Musculoskeletal, and Skin Diseases><Organoids><Pathway interactions><Patients><Pattern><Pediatric Hospitals><Periodicals><Peripheral><Persons><Ph.D.><PhD><Pharmaceutical Preparations><Phenotype><Physicians><Physiopathology><Population><Process><RNA Expression><RUNX3><RUNX3 gene><Receptor Protein><Recurrence><Recurrent><Recurrent disease><Relapsed Disease><Remission><Research Personnel><Research Resources><Researchers><Resistance><Resources><Rheumatoid Arthritis><Role><Runt-Related Transcription Factor 3><SIS cytokines><Scientist><Series><Signal Transduction><Signal Transduction Systems><Signaling><Single cell seq><Site><Sterility><Stromal Cells><Surface><Surface Proteins><Synovial Membrane><Synovium><System><T memory cell><T-Cell Activation><T-Cell Antigen Receptors><T-Cell Development><T-Cell Ontogeny><T-Cell Receptor><T-Cells><T-Lymphocyte><T-Lymphocyte Development><T8 Cells><T8 Lymphocytes><TGF-Beta Type II Receptor><TGFBR2><TGFBR2 gene><Task Forces><Testing><Therapeutic><Time><Tissue Differentiation><Tissue Model><Tissue-Specific Differential Gene Expression><Tissue-Specific Gene Expression><Tissues><Training><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Translational Research><Translational Science><Woman><Work><activate T cells><advisory team><analyze gene expression><arthritic><arthritis therapy><arthropathic><arthropathies><arthropathy><attenuate><attenuates><autoimmune condition><autoimmune disorder><autoimmunity disease><biological signal transduction><career><cell biology><cellular indexing of transcriptomes and epitopes by single cell sequencing><chemoattractant cytokine><chemokine><chronic autoimmune disease><confocal imaging><design><designing><developmental><disease control><disorder control><drug/agent><experience><gene expression analysis><gene expression assay><human disease><human model><immune activation><immunogen><inflamed joint><insight><joint disorder><joint inflammation><joint swelling><juvenile arthritis><juvenile idiopathic arthritis><lymph gland><lymph nodes><lymphnodes><mRNA Expression><medical college><medical schools><memory T lymphocyte><migration><model of human><mouse model><murine model><new approaches><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel approaches><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><pathophysiology><pathway><pediatric><periodic><periodical><prevent><preventing><protein expression><receptor><recruit><residence><resident memory T cell><residential building><residential site><resistant><rheumatic arthritis><rheumatologist><scRNA sequencing><scRNA-seq><school of medicine><single cell RNA-seq><single cell RNAseq><single cell analysis><single cell expression profiling><single cell next generation sequencing><single cell sequencing><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><sterile><therapeutic target><three dimensional><three-dimensional modeling><thymus derived lymphocyte><tissue resident memory T cell><transcriptional profiling><transcriptomics><transforming growth factor-beta type II receptor><transforming growth factor-β type II receptor><translation research><translational investigation><uptake>
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Kristen E Schratz

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$171,720
FY 2026

Project Title

Determinants of Myeloid Clonal Evolution

Grant Number:

5K08HL163468-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/5/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT ABSTRACT Clonal hematopoiesis is acquired with aging, and in some cases, precedes the onset of both myelodysplastic and myeloproliferative disorders. However, the genetic drivers that underlie the evolution of clonal hematopoiesis and the subsequent disease risk remain poorly understood. Thi...

Research Terms

<21+ years old><Adult><Adult Human><Affect><African American><Afro American><Afroamerican><Age><Aging><Applications Grants><Automobile Driving><Baltimore><Biological Markers><Blood><Blood Diseases><Blood Reticuloendothelial System><Blood erythrocyte><Cancers><Causality><Chromosomes><Clinical><Clonal Evolution><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><Clonality><Communities><Computational Biology><DNA Damage><DNA Injury><DNA mutation><Data><Development><Disease><Disease Outcome><Disease Progression><Disorder><Dysmyelopoietic Syndromes><EC 2.7.7.49><Early identification><Environment><Erythremia><Erythrocytes><Erythrocytic><Etiology><Event><Female Health><Functional RNA><Gene Alteration><Gene Mutation><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Germ Lines><Germ-Line Mutation><Goals><Grant Proposals><Hematologic Cancer><Hematologic Diseases><Hematologic Malignancies><Hematologic Neoplasms><Hematological Disease><Hematological Disorder><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic><Hematopoietic Cancer><Hereditary><Hereditary Mutation><Heritability><Individual><Inherited><JAK-2><JAK2><JAK2 gene><JAK2 protein><Janus kinase 2><Knowledge><Lead><Length><Life><Link><Long-term Follow-up><Malignant Hematologic Neoplasm><Malignant Neoplasms><Malignant Tumor><Marrow erythrocyte><Measures><Mendelian disease><Mendelian disorder><Mendelian genetic disorder><Mentors><Mentorship><Mutation><Myelodysplastic Disease><Myelodysplastic Syndromes><Myelodysplastic/Myeloproliferative Disease><Myelodysplastic/myeloproliferative neoplasm><Myelogenous><Myeloid><Myeloid Disease><Myeloid Malignancy><Myeloid Neoplasm><Myeloid Tumor><Myeloproliferative Disorders><Myeloproliferative Tumors><Myeloproliferative disease><Myeloproliferative/Myelodysplastic Disorders><Myeloproliferative/Myelodysplastic Syndromes><Noncoding RNA><Nontranslated RNA><Osler-Vaquez Disease><Participant><Patients><Pattern><Pb element><Phenotype><Phylogenetic Analysis><Phylogenetics><Polycythemia Rubra Vera><Polycythemia Vera><Population><Population Control><Prevalence><Prevention><Production><Progenitor Cells><Publications><RNA Transcriptase><RNA-Dependent DNA Polymerase><RNA-Directed DNA Polymerase><Red Blood Cells><Red Cell><Refractory Anemia with an Excess of Blasts><Refractory anaemia with excess blasts><Reporting><Reverse Transcriptase><Revertase><Risk><Risk Factors><Role><Sampling><Scientific Publication><Smoldering Leukemia><Solid><Syndrome><Telomerase><Telomerase RNA Component><Testing><Training><Tyrosine-Protein Kinase JAK2><United States><Universities><Untranslated RNA><Woman><Women's Health><Work><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><ages><autosome><bio-markers><biobank><biologic marker><biomarker><biorepository><blood corpuscles><blood disorder><causation><clinical validation><clonal expansions in the blood><clonal hematopoiesis><clones in hematopoietic cells><cohort><computer biology><developmental><disease causation><disease risk><disorder risk><driving><gain of function mutation><gene defect><genetic epidemiologic study><genetic epidemiology><genome mutation><germ-line defect><germline variant><heavy metal Pb><heavy metal lead><hematopoietic cell clones><hematopoietic stem cell clonality><hemopoietic><leukemia><long-term followup><loss of function><loss of function mutation><malignancy><medical college><medical schools><monogenic disease><monogenic disorder><mutant><mutant allele><myelodysplasia><myeloproliferative neoplasm><neoplasm/cancer><new approaches><new marker><noncoding><novel><novel approaches><novel biomarker><novel marker><novel strategies><novel strategy><population based><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><premature><prematurity><promoter><promotor><reconstruction><response><school of medicine><sequencing platform><single-gene disease><single-gene disorder><skills><social role><specific biomarkers><stem cells><telomerase RNA><telomere><trait>
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Vaibhav Upadhyay

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$169,020
FY 2026

Project Title

Impact of gut bacterial metabolites on lung function and disease

Grant Number:

5K08HL165106-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury (ALI), is common in COVID-19 and was a major driver of the now >1 million deaths in the USA since March 2020. Rigorous work has emphasized the key role the immune system and the microbiome ...

Research Terms

<3 Hydroxybutyrate><ARDS><Ablation><Acute Lung Injury><Acute Pulmonary Injury><Acute Respiratory Distress><Acute Respiratory Distress Syndrome><Adult ARDS><Adult RDS><Adult Respiratory Distress Syndrome><Advisory Committees><Alveolar><Area><Bacteria><Bifidobacterium><Biology><Blood Serum><COVID-19><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><CV-19><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Immune Function><Cellular Physiology><Cellular Process><Cessation of life><Clinical><Communication><Coronavirus Infectious Disease 2019><Coupled><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><Da Nang Lung><Data><Data Analyses><Data Analysis><Death><Disease><Disorder><Foundations><Future><GI microbiome><Generalized Growth><Genes><Germ-Free><Gnotobiotic><Gnotobiotics><Grant><Growth><Gut Epithelium><Health><Human><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><Immune system><Impairment><In Situ><In Vitro><Inflammation><Inflammatory><Injury><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin-17><Ketone Bodies><Ketones><Knowledge><Laboratories><Learning><Link><Liquid substance><Lobar Pneumonia><Lung><Lung Diseases><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Lung damage><Measurement><Measures><Mediating><Mentors><Mice><Mice Mammals><Microbiology><Microbiomics><Modeling><Modern Man><Molecular><Murine><Mus><NHLBI><National Heart, Lung, and Blood Institute><Organism><Pathology><Pathway interactions><Patients><Phenotype><Physicians><Physiologic><Physiological><Play><Pneumococcal Pneumonia><Pneumonia><Position><Positioning Attribute><Pulmonary Diseases><Pulmonary Disorder><Research><Research Infrastructure><Research Resources><Resources><Role><Scientist><Serum><Severities><Shock Lung><Stiff lung><Strategic vision><Structure of parenchyma of lung><Subcellular Process><T-Cells><T-Lymphocyte><Task Forces><Technology><Testing><Tissue Growth><Training><Work><advisory team><bacteria in the gut><bacteria metabolism><bacterial metabolism><beta-Hydroxybutyrate><career><career development><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><data interpretation><digestive tract microbiome><disease of the lung><disorder of the lung><enteric microbiome><experiment><experimental research><experimental study><experiments><fluid><gastrointestinal epithelium><gastrointestinal microbiome><gut bacteria><gut microbiome><gut-associated microbiome><immune function><in vivo><injuries><innovate><innovation><innovative><intestinal biome><intestinal epithelium><intestinal microbiome><ketogenic><ketogentic><liquid><living system><lung disorder><lung function><lung injury><microbiome><microbiome research><microbiome science><microbiome studies><microorganism><ontogeny><pathway><programs><pulmonary><pulmonary damage><pulmonary function><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><response><skills><small molecule><social role><thymus derived lymphocyte><tool><training opportunity><wet lung><β-Hydroxybutyrate>
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Yuri Kim

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$168,993
FY 2026

Project Title

Development of strategies to enhance titin (TTN) expression and treat dilated cardiomyopathy caused by TTN haploinsufficiency

Grant Number:

5K08HL164885-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Heterozygous truncating variants in the essential sarcomere protein titin (TTNtv) are the most common genetic cause of dilated cardiomyopathy (DCM), dilatation and contractile dysfunction of one or both ventricles of the heart. DCM often progresses to heart failure (HF), a d...

Research Terms

<5' Untranslated Regions><5'UTR><Applied Genetic Engineering><Assay><Award><Bioassay><Biologic Models><Biological Assay><Biological Models><CRISPR><CRISPR/Cas system><Cardiac><Cardiac Abnormalities><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac Ventricles><Cardiocyte><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Causality><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cessation of life><Clustered Regularly Interspaced Short Palindromic Repeats><Congestive Cardiomyopathy><Conserved Sequence><DNA editor><DNA mutation><Data><Death><Development><Dilatation><Dilatation - action><Dilated Cardiomyopathy><Disease><Disorder><Dysfunction><Elements><Engineering><Enhancers><Etiology><Evolution><Foundations><Functional disorder><Funding><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Gene variant><Genetic><Genetic Change><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Transcription><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Genomics><Goals><Heart><Heart Abnormalities><Heart Muscle Cells><Heart Vascular><Heart Ventricle><Heart failure><Heart myocyte><Heterozygote><Hospital Admission><Hospitalization><Hospitals><Human><Impairment><In Vitro><Individual><Intervening Sequences><Intracellular Communication and Signaling><Introns><Investigation><Knowledge><Laboratories><Left><Mediating><Medical Directors><Medicine><Mentorship><Mice><Mice Mammals><Model System><Modern Man><Morbidity><Murine><Mus><Mutagenesis><Mutagenesis Molecular Biology><Mutate><Mutation><Myocardial depression><Myocardial dysfunction><Nucleic Acid Regulator Regions><Nucleic Acid Regulatory Sequences><ORFs><Open Reading Frames><Pathogenesis><Pathogenicity><Patients><Physician Executives><Physiology><Physiopathology><Population><Prevalence><Protein Coding Region><Proteins><RNA Expression><Recombinant DNA Technology><Regulator Genes><Regulatory Element><Regulatory Regions><Reporter><Research><Role><SEQ-AN><Sarcomeres><Scientist><Sequence Analyses><Sequence Analysis><Signal Transduction><Signal Transduction Systems><Signaling><Site-Directed Mutagenesis><Site-Specific Mutagenesis><Structure><System><Targeted DNA Modification><Targeted Modification><Teaching Hospitals><Technology><Testing><Therapeutic><Transcription><Transcription Activation><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcriptional Activation><Transcriptional Activator/Coactivator><Transcriptional Regulatory Elements><Translations><Variant><Variation><Ventricular><Woman><Work><allelic variant><biological signal transduction><cardiac dysfunction><cardiac failure><cardiac myocytes differentiated from induced pluripotent stem cell><cardiomyocyte><causation><circulatory system><comparative><connectin><developmental><disease causation><familial cardiomyopathy><functional improvement><gain of function mutation><gene editor><genetic cardiomyopathy><genetic regulatory element><genetic trans acting element><genetic variant><genetically engineered><genome editing><genome editor><genome mutation><genomic editing><genomic variant><heart dysfunction><hereditary cardiomyopathy><heterozygosity><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><iPS cell derived cardiomyocytes><iPSC derived cardiomyocytes><improve function><improved><improved functional outcomes><in vivo><induced human pluripotent stem cells><induced pluripotent stem cell derived cardiac myocytes><induced pluripotent stem cell derived cardiomyocytes><inducible pluripotent stem cell derived cardiac myocytes><inducible pluripotent stem cells derived cardiomyocytes><inherited cardiomyopathy><mRNA Leader Sequences><medical college><medical schools><mortality><mouse genome><mouse model><murine model><mutant><pathophysiology><prevent><preventing><professor><promoter><promotor><protein expression><recruit><regulatory gene><repair><repaired><school of medicine><screening><screenings><skills><social role><stem><titin><trans acting element><translation>
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Arvind Kant Pandey

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$167,400
FY 2026

Project Title

Immuno-Metabolic Regulation of Vascular Dysfunction by CD70

Grant Number:

5K08HL177156-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Cardiovascular diseases constitute a tremendous health care burden, and despite increased attention, cardiovascular mortality continues to increase in the United States and worldwide. While immune activation and inflammation are critical to atherosclerotic cardiovascular di...

Research Terms

<(TNF)-α><ASCVD><Affect><Applications Grants><Assay><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Attention><Award><Binding><Bioassay><Bioavailability><Bioenergetics><Biological Assay><Biological Availability><Biological Response Modifiers><Biology><Biomodulators><Biosensor><Blood Vessels><Cachectin><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cause of Death><Cell Communication and Signaling><Cell Function><Cell Membrane Lipid Rafts><Cell Physiology><Cell Process><Cell Signaling><Cellular Function><Cellular Metabolic Process><Cellular Physiology><Cellular Process><Cessation of life><Characteristics><Clinical Investigator Award><Closure by Ligation><Co-Immunoprecipitations><Data><Death><Dedications><Development><Development Plans><ENOS><Endogenous Nitrate Vasodilator><Endothelial Cells><Endothelial Nitric Oxide Synthase><Endothelium><Endothelium-Derived Nitric Oxide><Environment><Enzyme Gene><Enzymes><Foundations><Funding><Generalized Growth><Generations><Genetic Polymorphism><Goals><Grant Proposals><Growth><Health Care><Heart Vascular><Hospitals><Immune><Immune Cell Activation><Immune Mediators><Immune Mediators/Modulators><Immune Targeting><Immunes><Impairment><Inflammation><Inflammation Mediators><Inflammatory><Injury><Institution><Intermediary Metabolism><Intracellular Communication and Signaling><Investigators><K-Awards><K-Series Research Career Programs><K08 Mechanism><K08 Program><KO mice><Knock-out Mice><Knockout Mice><Label><Laboratories><Leukocyte Rolling><Ligation><Link><Macromolecular Complexes><Macrophage-Derived TNF><Mediating><Membrane Microdomains><Membrane Potentials><Mentored Clinical Scientist Development Award (K08)><Mentored Clinical Scientists Development Award><Mentors><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Mice><Mice Mammals><Mitochondria><Molecular Interaction><Monocyte-Derived TNF><Mononitrogen Monoxide><Morphology><Murine><Mus><Myography><NOS3><NOS3 gene><Nitric Oxide><Nitric Oxide Synthase 3><Nitrogen Monoxide><Nitrogen Protoxide><Null Mouse><Oxidation-Reduction><Oxidative Stress><Pathogenesis><Pathway interactions><Peptide/Protein Chemistry><Phased Career Development><Phenotype><Physicians><Physiologic><Physiologic Availability><Physiological><Physiology><Principal Investigator><Protein Chemistry><Proteins><Redox><Regulation><Research><Research Activity><Research Career Program><Research Personnel><Research Resources><Research Support><Researchers><Resources><Resting Potentials><Role><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Sphingolipid Microdomains><Sphingolipid-Cholesterol Rafts><Subcellular Process><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Techniques><Testing><Time><Tissue Growth><Training><Training Activity><Training Programs><Transmembrane Potentials><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Type III nitric oxide synthase><United States><Vascular Diseases><Vascular Disorder><Vasodilatation><Vasodilation><Vasorelaxation><Viral><Woman><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><biological sensor><biological signal transduction><blood vessel disorder><cardiovascular disorder><career development><cell metabolism><cellular metabaolism><circulatory system><developmental><disease phenotype><endothelial cell derived relaxing factor><endothelial dysfunction><extracellular><health care burden><immune activation><inflammatory mediator><injuries><insight><knock-down><knockdown><leukocyte activation><lipid raft><medical college><medical schools><member><metabolic profile><metabolism measurement><metabolomics><metabonomics><migration><mitochondrial><mitochondrial membrane><mortality><mouse model><murine model><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><ontogeny><overexpress><overexpression><oxidation reduction reaction><pathway><phenome><polymorphism><programs><protein protein interaction><response><responsible research conduct><scRNA sequencing><scRNA-seq><school of medicine><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><training module><vascular><vascular dysfunction><vascular inflammation><vasculopathy>
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Kelsey Nicole Serier

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$165,691
FY 2026

Project Title

Longitudinal Associations of Posttraumatic Stress Disorder with Incident Type 2 Diabetes and Poor Glycemic Control in a Large National Cohort

Grant Number:

5K08DK138296-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2024

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary This K08 Mentored Clinical Scientist Development Award will provide Dr. Kelsey Serier with training to develop an independent research career devoted to understanding the effect of trauma and trauma-related negative mental health sequalae, namely posttraumatic stress disorder (PTSD),...

Research Terms

<21+ years old><Active Follow-up><Address><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Attention><Autonomic Dysfunction><Award><Behavioral Sciences><Biological><Black><Black race><Chronic><Cox Proportional Hazards Models><Data><Data Analyses><Data Analysis><Data Sources><Development><Diabetes Mellitus><Diabetes prevention><Diagnosis><Diagnostic><Electronic Health Record><Endocrinology><Environmental Factor><Environmental Risk Factor><Epidemiologic Methodology><Epidemiologic Methods><Epidemiologic research methodology><Epidemiologic research methods><Epidemiological Methods><Epidemiological Techniques><Epidemiology><Ethnic Origin><Ethnicity><Exposure to><Female Health><Foundations><Future><Glycohemoglobin A><Glycosylated hemoglobin A><Goals><Grant><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Health><Health Care Costs><Health Costs><Health Informatics><Hemoglobin A(1)><Hispanic><Homelessness><Incidence><Individual><Intervention><Investigation><Investigators><Ketosis-Resistant Diabetes Mellitus><Knowledge><Laboratories><Latino><Link><Literature><Logistic Regressions><Long-term cohort><Longitudinal Studies><Longitudinal Surveys><Longitudinal cohort><Maturity-Onset Diabetes Mellitus><Measures><Medical><Mental Depression><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Mentored Clinical Scientist Development Award (K08)><Mentored Clinical Scientists Development Award><Mentorship><Metabolism and Endocrinology><Methodology><Methods Epidemiology><Methods in epidemiology><Modeling><Modification><Morbidity><NIDDK><NIDDM><National Institute of Diabetes and Digestive and Kidney Diseases><Non-Hispanic><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Nonhispanic><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Not Hispanic or Latino><Outcome><PTSD><Pathway interactions><Patient Self-Report><Phased Career Development><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Prevalence><Prevention><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Psychosocial Factor><Public Health><Public Health Informatics><Race><Races><Research><Research Personnel><Researchers><Risk><Risk Factors><Role><Sampling><Science><Self-Report><Series><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Subgroup><Survey Instrument><Surveys><T2 DM><T2D><T2DM><Testing><Time><Training><Trauma><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States><Variant><Variation><Veterans><Veterans Health Administration><Veterans Health Affairs><Woman><Women's Health><Work><Writing><active followup><adult onset diabetes><adulthood><biologic><burden of disease><burden of illness><career><co-morbid><co-morbid depression><co-morbid with depression><co-morbidity><co-morbidity with depression><cohort><comorbid depression><comorbid with depression><comorbidity><comorbidity with depression><comparator group><comparison group><consumer informatics><cost><data interpretation><depression><depression co-morbidity><depression comorbidity><design><designing><developmental><diabetes><diabetes risk><diabetes self-care><diabetes self-management><disease burden><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><environmental risk><epidemiologic><epidemiological><ethnic identity><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><exposure to trauma><follow up><follow-up><followed up><followup><food insecure><food insecurity><food scarcity><glycemic control><group of color><hemoglobin A1c><homeless><houselessness><individual of color><ketosis resistant diabetes><long-term study><longitudinal outcome studies><longitudinal research study><low food security><malleable risk><maturity onset diabetes><mental illness><minority health><modifiable risk><mortality><novel><pathway><people of color><person of color><physical conditioning><physical health><poor sleep><population of color><post-trauma stress disorder><posttrauma stress disorder><programs><prospective><psychiatric co-morbidity><psychiatric comorbidity><psychiatric illness><psychologic><psychological><psychological disorder><psychosocial variables><racial><racial background><racial diversity><racial identity><racial minority group><racial minority individual><racial minority people><racial minority population><racial origin><racially diverse><sex><skills><social factors><social role><trauma exposure><traumatic neurosis><traumatic stress><type 2 DM><type II DM><type two diabetes><unhoused>
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Vincent Lingzhi Chen

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$165,240
FY 2026

Project Title

Predictive models for incident cirrhosis in non-alcoholic fatty liver disease using genetic and electronic medical record-based risk factors

Grant Number:

5K08DK132312-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Non-alcoholic fatty liver disease (NAFLD) affects >80 million people in the United States and is implicated in up 36% of liver-related deaths. While NAFLD is the fastest-growing cause of cirrhosis and liver-related complications, not all patients with NAFLD ultimately develo...

Research Terms

<Active Follow-up><Address><Affect><Age><Alleles><Allelomorphs><American><Applied Genetics><Award><Biopsy><Calibration><Cessation of life><Cirrhosis><Clinical><Clinical genetics><Complex><Computerized Medical Record><Data><Data Set><Death><Disease Progression><Drug Therapy><Electronic Medical Record><Fatty Liver><Fibrosis><GWA study><GWAS><Gene variant><Gene x Environment Interaction><Genetic><Genetic predisposing factor><Goals><Grant><GxE interaction><Hepatic Cirrhosis><Hepatic Disorder><Heritability><Heterogeneity><Impairment><Intervention><Investigators><Knowledge><Laboratories><Link><Literature><Liver><Liver Cirrhosis><Liver Fibrosis><Liver Steatosis><Liver diseases><Logistic Regressions><Machine Learning><Medical><Medical Genetics><Medicine><Metabolic><Michigan><Modeling><NAFLD><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Participant><Patient Care><Patient Care Delivery><Patients><Persons><Pharmacological Treatment><Pharmacotherapy><Phenotype><Population><Precision Health><Predicting Risk><Process><Provider><Quality Control><Research><Research Personnel><Researchers><Resource Allocation><Risk><Risk Factors><Source><Structure><Subgroup><Therapeutic Intervention><Time><Training><United States><Variant><Variation><Writing><active followup><ages><allelic variant><base><bases><biobank><biorepository><care for patients><care of patients><career><caring for patients><cirrhotic><clinical practice><co-morbid><co-morbidity><cohort><comorbidity><competing risk><computer based prediction><cost><death risk><demographics><disease diagnosis><disease model><disorder model><drug intervention><drug treatment><elastic imaging><elasticity imaging><elastography><environment effect on gene><fibrotic liver><follow up><follow-up><followed up><followup><forecasting risk><gene environment interaction><genetic predictors><genetic risk factor><genetic variant><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic variant><hepatic body system><hepatic disease><hepatic fibrosis><hepatic organ system><hepatic steatosis><hepatopathy><hepatosteatosis><high dimensional data><high risk><improved><indexing><inherited factor><interest><intervention therapy><life style intervention><lifestyle intervention><liver disorder><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><machine learning based model><machine learning based prediction model><machine learning based predictive model><machine learning model><machine learning prediction><machine learning prediction model><mortality risk><multidimensional data><multidimensional datasets><non-alcohol fatty liver disease><non-alcoholic fatty liver disease><non-alcoholic liver disease><nonalcoholic fatty liver disease><novel><outcome prediction><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><polygenetic risk scores><polygenic risk score><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive modeling><predictive risk><predicts risk><progression risk><prospective><risk prediction><risk predictions><risk stratification><stratify risk><substance use><substance using><time to event><time to occurrence><weight loss program><weight loss programming><whole genome association analysis><whole genome association study>
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Chao He

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$164,376
FY 2026

Project Title

Mechanosignaling regulates macrophage immunometabolism

Grant Number:

5K08HL163406-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Pulmonary fibrosis is a class of disease conditions characterized by subacute and chronic progressive scarring of the lungs. The most common form, idiopathic pulmonary fibrosis (IPF), has a prevalence of 1 in 200 among people older than 65. IPF is a devastating disease with a median ...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Acclimatization><Adult><Adult Human><Aged 65 and Over><Animals><Attenuated><B cell growth factor><B-Cell Differentiation Factor-1><B-Cell Growth Factor-1><B-Cell Growth Factor-I><B-Cell Proliferating Factor><B-Cell Stimulating Factor><B-Cell Stimulating Factor-1><B-Cell Stimulation Factor-1><B-Cell Stimulatory Factor-1><BCDF-1><BCGF><BCGF-1><BCSF 1><BSF-1><BSF1><Basal Transcription Factor><Basal transcription factor genes><Binetrakin><Biochemical><Biology><Blood monocyte><CD61><CD61 Antigens><Causality><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cell surface><Cell-Extracellular Matrix><Cellular Function><Cellular Mechanotransduction><Cellular Physiology><Cellular Process><Characteristics><Chronic><Cicatrix><Communication><Data><Development><Development Plans><Disease><Disorder><ECM><Environment><Etiology><Extracellular Matrix><Fibrosing Alveolitis><Fibrosis><Fibrotic lesions in lung><GP IIIa><GP3A><GPIIIa><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Growth><Hepatic Proliferation Inhibitor><IL-4><IL4 Protein><ITGB3><ITGB3 gene><Immunity><Integrin Beta 3><Integrin aVBeta3><Integrin alpha-v beta-3><Integrin alphaVbeta3><Integrin beta3><Integrin αVβ3><Integrin β3><Integrins><Integrins Extracellular Matrix><Interleukin-4><Interleukin-4 Precursor><Intermediary Metabolism><Interruption><Intracellular Communication and Signaling><Knowledge><L arginine amidinohydrolase><Liver Immunoregulatory Protein><Liver-Derived Inhibitory Protein><Lung><Lung Respiratory System><Lung Tissue Fibrosis><Lung scar><Lung tissue scar><Lymphocyte Stimulatory Factor 1><MCGF-2><Macrophage><Macrophage Activation><Marrow monocyte><Mast Cell Growth Factor-2><Mechanical Signal Transduction><Mechanosensory Transduction><Mediating><Mentorship><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Mice><Mice Mammals><Murine><Mus><Mφ><NAIT><Older Population><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><PPAR gamma><PPAR-g><PPAR-γ><PPARgamma><PPARγ><PTP gene><Pathogenesis><Pathway interactions><Peroxisome Proliferative Activated Receptor Gamma><Peroxisome Proliferator-Activated Receptor gamma><Peroxisome Proliferator-Activated Receptor γ><Phenotype><Physicians><Platelet Fibrinogen Receptor, Beta Subunit><Platelet GPIIIa><Platelet Glycoprotein IIIa><Platelet Membrane Glycoprotein IIIa><Prevalence><Process><Pulmonary Fibrosis><Pulmonary Scar><Pulmonary Tissue fibrosis><Research><Research Proposals><Role><Scarring at the lung><Scarring in the lung><Scars><Scientist><Series><Signal Transduction><Signal Transduction Systems><Signaling><Stimulant><Subcellular Process><T-Cell Growth Factor 2><Testing><Thiazolidinedione Receptor><Tissue Growth><Training><Transcription Factor Proto-Oncogene><Transcription factor genes><aVBeta3><above age 65><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><alpha-v beta-3 Integrin Receptors><arginase><arginine amidinase><attenuate><attenuates><biological signal transduction><canavanase><career development><causation><cytokine><developmental><diffuse interstitial pulmonary fibrosis><disease causation><drug development><experience><experiment><experimental research><experimental study><experiments><extracellular><fatty acid oxidation><fibrosis in the lung><fibrotic lung><fibrotic lung disease><fibrotic pulmonary disease><human old age (65+)><human subject><idiopathic pulmonary fibrosis><in vivo><lung fibrosis><lung health><mechanical cue><mechanical properties><mechanical signal><mechanosensing><mechanotransduction><metabolism measurement><metabolomics><metabonomics><monocyte><mouse model><multidisciplinary><murine model><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><older groups><older individuals><older person><ontogeny><over 65 years><pathway><pulmonary health><skills><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transcription factor><≥65 years>
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Dominic Edward Fullenkamp

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$164,052
FY 2026

Project Title

Physiologic stress in advanced tissue culture models of cardiomyopathy

Grant Number:

5K08HL163392-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/15/2022

End Date:

11/30/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Multiple forms of muscular dystrophy are characterized by cardiac involvement which can be life-threatening, including Duchenne muscular dystrophy (DMD) and LMNA-related muscular dystrophy. These diseases are caused by mutations in DMD and LMNA, respectively. Heart failure i...

Research Terms

<2-dimensional><3-D><3-Dimensional><3D><Affect><Annexin A6><Annexin VI><Arrhythmia><Award><Biological Markers><Biology><Biomedical Engineering><Body Tissues><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Calcimedin 67-kDa><Calcium and Phospholipid-Binding Protein p68><Calelectrin 67-kDa><Calphobindin II><Cardiac><Cardiac Arrhythmia><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiology><Cardiomyopathies><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Line><Cell Nucleus><Cell Signaling><Cell membrane><Cell-Extracellular Matrix><CellLine><Cells><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Collaborations><Complex><Congestive Cardiomyopathy><Cytoplasmic Membrane><DNA Therapy><DNA mutation><Data><Defect><Development><Development Plans><Dilated Cardiomyopathy><Disease><Disorder><Doctor of Philosophy><Duchene><Duchenne><Duchenne muscular dystrophy><Duchenne-Griesinger syndrome><Dystrophin><ECM><Effectiveness><Electrophysiology><Electrophysiology (science)><Ellis-van Creveld (EvC) syndrome><Engineering><Ensure><Extracellular Matrix><Gene Transfer Clinical><Genes><Genetic><Genetic Change><Genetic Diseases><Genetic Intervention><Genetic Medicine><Genetic defect><Genetic mutation><Heart><Heart Arrhythmias><Heart Muscle Cells><Heart Vascular><Heart failure><Heart myocyte><Human><Hydrogels><Injury><Intermediate Filaments><Intracellular Communication and Signaling><Investigators><Lamin A><Lamin Type A><Lead><Left Ventricular Dysfunction><Life><Link><Lipocortin VI><Measurement><Measures><Mechanical Stress><Mechanics><Membrane><Mentors><Mentorship><Methods><Modeling><Modern Man><Morbidity><Muscular Dystrophies><Mutation><Myocardial Diseases><Myocardial Disorder><Myocardiopathies><Myocardium><Myodystrophica><Myodystrophy><Neurophysiology / Electrophysiology><Nuclear Envelope><Nuclear Lamina><Nuclear Membrane><Nucleus><Output><Pathologic><Patients><Pb element><Ph.D.><PhD><Phenotype><Physicians><Physiologic><Physiological><Plasma Membrane><Play><Predisposition><Proteins><Pseudohypertrophic Muscular Dystrophy><Recombinants><Research><Research Personnel><Researchers><Role><Sarcomeres><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Skeletal Muscle><Strains Cell Lines><Stress><Structural Protein><Susceptibility><System><Technology><Testing><Therapeutic Effect><Tissue constructs><Tissues><Training><Transmission><Troponin><Universities><Voluntary Muscle><Work><X-linked dilated cardiomyopathy><X-linked muscular dystrophy><X-linked recessive muscular dystrophy><bench bed side><bench bedside><bench to bed side><bench to bedside><bench to clinic><bench to clinical practice><benign X-linked recessive muscular dystrophy><bio-engineered><bio-engineers><bio-markers><bioengineering><biologic marker><biological engineering><biological signal transduction><biomarker><cardiac failure><cardiac muscle><cardiac myocytes differentiated from induced pluripotent stem cell><cardiac tissue engineering><cardiomyocyte><career development><childhood pseudohypertrophic muscular dystrophy><circulatory system><classic X-linked recessive muscular dystrophy><clinical relevance><clinical translation><clinically relevant><clinically translatable><compare to control><comparison control><cultured cell line><customized therapy><customized treatment><developmental><drug detection><drug testing><electrical measurement><electrophysiological><engineered heart tissue><exon skipping><experience><flex circuit><flexibility><flexible><flexible electronics><gene repair therapy><gene therapy><gene-based therapy><genetic condition><genetic disorder><genetic therapy><genome mutation><genomic therapy><heart muscle><heavy metal Pb><heavy metal lead><iPS><iPS cell derived cardiomyocytes><iPSC><iPSC derived cardiomyocytes><iPSCs><improved><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell derived cardiac myocytes><induced pluripotent stem cell derived cardiomyocytes><induced pluripotent stem cells derived from patients><induced pluripotent stem cells from patients><inducible pluripotent cell><inducible pluripotent stem cell><inducible pluripotent stem cell derived cardiac myocytes><inducible pluripotent stem cells derived cardiomyocytes><inhibitor><injuries><interest><left ventricle abnormality><male><measurement of electrical properties><mechanic><mechanical><membrane structure><mild X-linked recessive muscular dystrophy><monolayer><mortality><muscle dystrophy><mutant><myocardium disease><myocardium disorder><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><patient derived human iPS><patient derived human iPSC><patient derived human induced pluripotent stem cell><patient derived iPS><patient derived iPSC><patient derived induced pluripotent cells><patient derived induced pluripotent stem cells><patient specific therapies><patient specific treatment><patient-derived pluripotent stem cells><plasmalemma><progressive muscular dystrophy of childhood><protein complex><prototype><pseudohypertrophic adult muscular dystrophy><pseudohypertrophic muscular paralysis><response><social role><stressor><tailored medical treatment><tailored therapy><tailored treatment><therapeutic evaluation><therapeutic testing><three dimensional><tissue culture><transmission process><two-dimensional><unique treatment><♂>
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Britny Hildebrandt

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$162,502
FY 2026

Project Title

Dissecting circuits underlying loss of control relevant to binge eating

Grant Number:

5K08DK136916-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT Obesity is a critical public health problem associated with substantial morbidity and mortality. Binge eating (BE), a compulsive episodic overeating behavior, is associated with increased rates of obesity and weight gain. Despite the negative impact of BE on physiological health and obesity...

Research Terms

<Acceleration><Acute><Adult-Onset Diabetes Mellitus><Animal Model><Animal Models and Related Studies><Area><Behavior><Behavior Control><Behavior assessment><Behavioral><Behavioral Manipulation><Behavioral Paradigm><Binge Eating><Calcium><Cell Body><Cells><Chronic><Clinical Research><Clinical Study><Complex><Corpus Striatum><Corpus striatum structure><Data><Development><Diagnostic><Eating><Eating Behavior><Ensure><Event><Feeding behaviors><Fiber><Food><Food Access><Food Intake><Foundations><Future><General Population><General Public><Goals><Health><Hyperphagia><Image><Impairment><In vivo two-photon calcium imaging><Ingestive Behavior><Intervention><Investigation><Ketosis-Resistant Diabetes Mellitus><Learning><Link><Maturity-Onset Diabetes Mellitus><Measurement><Mediating><Mediation><Medical><Mice><Mice Mammals><Mission><Morbidity><Motor Cortex><Murine><Mus><NIDDM><Negotiating><Negotiation><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Obesity><Overeating><Pathologic><Pattern><Photometry><Physiologic><Physiological><Population><Pre-Clinical Model><Preclinical Models><Protocol><Protocols documentation><Public Health><Research><Resolution><Rewards><Role><Scientist><Slow-Onset Diabetes Mellitus><Specificity><Stable Diabetes Mellitus><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Striate Body><Striatum><System><T2 DM><T2D><T2DM><Technical Expertise><Techniques><Training><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Weight Gain><Weight Increase><Work><adiposity><adult onset diabetes><behavior measurement><behavioral assessment><behavioral control><behavioral measure><behavioral measurement><body weight gain><body weight increase><career><cell type><compulsive eating><compulsive feeding><compulsive overeating><corpulence><developmental><feeding><feeding-related behaviors><food Ingestion><food consumption><imaging><improved><in vivo><in vivo calcium imaging><ketosis resistant diabetes><loss of control eating><loss of control over eating><maladaptive behavior><maturity onset diabetes><model of animal><mortality><neural><neural correlate><neural mechanism><neuromechanism><neuronal><novel><nutrient intake activity><obesity risk><optogenetics><polyphagia><prevent><preventing><programs><resolutions><risk for obesity><risk of obesity><skills><social role><statistical analysis><striatal><technical skills><translational impact><type 2 DM><type II DM><type two diabetes><wt gain>
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Sherin U Devaskar

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 48/100
Training-friendly
Very recent
Active award
$161,356
FY 2026

Project Title

UCLA Pediatric Research Education Program in Bioinformatics, Computational Biology, and Omics

Grant Number:

5R25HD109116-04

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2023

End Date:

4/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Bioinformatics, computational biology, and omics are important areas that have the potential to uncover new discoveries in the molecular/cellular mechanisms and gene networks that lead to congenital birth defects, metabolic and genetic disorders, organ dysfunction, disorders...

Research Terms

<Address><Area><Basic Research><Basic Science><Big Data><BigData><Bioinformatics><Biologic Sciences><Biological Sciences><Biometrics><Biometry><Bioscience><Biostatistics><Birth Defects><Cancers><Causality><Childhood><Childhood Cancers><Clinical><Clinical Medical Sciences><Clinical Medicine><Clinical Research><Clinical Study><Collaborations><Complex><Computational Biology><Computational Science><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Malformation><DNA Methylation><Data Analyses><Data Analysis><Data Set><Development><Diagnosis><Discipline><Disease><Disorder><Doctor of Philosophy><Dysfunction><E-learning><Education><Education Gap><Education and Training><Educational Achievement><Educational Status><Educational aspects><Educational process of instructing><Educational workshop><Endocrine Diseases><Endocrine Diseases and Manifestations><Endocrine System Diseases><Etiology><Faculty><Fostering><Foundational Skills><Functional disorder><Funding><Future><Genetic Diseases><Health><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Hybrids><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Individual><Institution><Instruction><Intervention><Investigators><Journals><K12><K12 Award><K12 Mechanism><K12 Program><Knowledge><Life><Life Cycle><Life Cycle Stages><Life Sciences><Link><Magazine><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Neoplasms><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant Tumor><Malignant childhood cancer><Medical><Mentored Clinical Scientist Development Program><Mentors><Metabolic Diseases><Metabolic Disorder><Molecular><Network Analysis><Organ><Pathway Analysis><Pathway interactions><Patient Care><Patient Care Delivery><Patients><Pediatric Research><Pediatrics><Ph.D.><PhD><Physicians><Physiopathology><Postdoc><Postdoctoral Fellow><Preventative strategy><Prevention strategy><Preventive strategy><Proteome><Research><Research Associate><Research Personnel><Research Support><Researchers><Scholarship><Science><Scientist><Systemic disease><Talents><Teaching><Techniques><Technology><Thesaurismosis><Training><Training and Education><Translational Research><Translational Science><Workshop><analyze microbiome><big biomedical data><big-data science><cancer in a child><cancer in children><care for patients><care of patients><career><caring for patients><causation><child health care><child patients><child with cancer><childhood malignancy><classroom environment><collaboratory><college atmosphere><collegial atmosphere><collegiate atmosphere><computer biology><computer-assisted instruction><computer-based education><computer-based instruction><computer-based learning><computer-based training><data interpretation><developmental><digital education><digital learning><disease causation><disease risk><disorder risk><eLearning><education atmosphere><education research><educational atmosphere><educational environment><educational level><electronic learning><endocrine disorder><entire genome><epigenome><experience><flipped classroom><forging><full genome><gene network><genetic condition><genetic disorder><genome sequencing><global gene expression><global transcription profile><graduate medical education><intellectual atmosphere><interest><internet-assisted education><internet-based training><large scale biomedical data sets><large scale biomedical datasets><large-scale biomedical data><learning atmosphere><learning environment><lectures><life course><malignancy><medical college><medical schools><member><metabolism disorder><metabolome><metabonome><metagenome><microbiome analysis><multidisciplinary><multimedia learning><neoplasm/cancer><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><next generation><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><on-line education><on-line learning><online education><online learning><pathophysiology><pathway><pediatric><pediatric cancer><pediatric care><pediatric department><pediatric health care><pediatric malignancy><pediatric patients><post-doc><post-doctoral><post-doctoral trainee><precision medicine><precision-based medicine><programs><recruit><research associates><scRNA sequencing><scRNA-seq><school atmosphere><school climate><school of medicine><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><technology-enhanced learning><tool><training achievement><training atmosphere><training level><training status><transcriptome><translation research><translational investigation><trend><undergrad><undergraduate><undergraduate student><university atmosphere><virtual learning><web-based instruction><web-based training><whole genome>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

JOSEPHINE M ENCISO

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 48/100
Training-friendly
Very recent
Active award
$161,356
FY 2026

Project Title

UCLA Pediatric Research Education Program in Bioinformatics, Computational Biology, and Omics

Grant Number:

5R25HD109116-04

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2023

End Date:

4/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Bioinformatics, computational biology, and omics are important areas that have the potential to uncover new discoveries in the molecular/cellular mechanisms and gene networks that lead to congenital birth defects, metabolic and genetic disorders, organ dysfunction, disorders...

Research Terms

<Address><Area><Basic Research><Basic Science><Big Data><BigData><Bioinformatics><Biologic Sciences><Biological Sciences><Biometrics><Biometry><Bioscience><Biostatistics><Birth Defects><Cancers><Causality><Childhood><Childhood Cancers><Clinical><Clinical Medical Sciences><Clinical Medicine><Clinical Research><Clinical Study><Collaborations><Complex><Computational Biology><Computational Science><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Malformation><DNA Methylation><Data Analyses><Data Analysis><Data Set><Development><Diagnosis><Discipline><Disease><Disorder><Doctor of Philosophy><Dysfunction><E-learning><Education><Education Gap><Education and Training><Educational Achievement><Educational Status><Educational aspects><Educational process of instructing><Educational workshop><Endocrine Diseases><Endocrine Diseases and Manifestations><Endocrine System Diseases><Etiology><Faculty><Fostering><Foundational Skills><Functional disorder><Funding><Future><Genetic Diseases><Health><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Hybrids><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Individual><Institution><Instruction><Intervention><Investigators><Journals><K12><K12 Award><K12 Mechanism><K12 Program><Knowledge><Life><Life Cycle><Life Cycle Stages><Life Sciences><Link><Magazine><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Neoplasms><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant Tumor><Malignant childhood cancer><Medical><Mentored Clinical Scientist Development Program><Mentors><Metabolic Diseases><Metabolic Disorder><Molecular><Network Analysis><Organ><Pathway Analysis><Pathway interactions><Patient Care><Patient Care Delivery><Patients><Pediatric Research><Pediatrics><Ph.D.><PhD><Physicians><Physiopathology><Postdoc><Postdoctoral Fellow><Preventative strategy><Prevention strategy><Preventive strategy><Proteome><Research><Research Associate><Research Personnel><Research Support><Researchers><Scholarship><Science><Scientist><Systemic disease><Talents><Teaching><Techniques><Technology><Thesaurismosis><Training><Training and Education><Translational Research><Translational Science><Workshop><analyze microbiome><big biomedical data><big-data science><cancer in a child><cancer in children><care for patients><care of patients><career><caring for patients><causation><child health care><child patients><child with cancer><childhood malignancy><classroom environment><collaboratory><college atmosphere><collegial atmosphere><collegiate atmosphere><computer biology><computer-assisted instruction><computer-based education><computer-based instruction><computer-based learning><computer-based training><data interpretation><developmental><digital education><digital learning><disease causation><disease risk><disorder risk><eLearning><education atmosphere><education research><educational atmosphere><educational environment><educational level><electronic learning><endocrine disorder><entire genome><epigenome><experience><flipped classroom><forging><full genome><gene network><genetic condition><genetic disorder><genome sequencing><global gene expression><global transcription profile><graduate medical education><intellectual atmosphere><interest><internet-assisted education><internet-based training><large scale biomedical data sets><large scale biomedical datasets><large-scale biomedical data><learning atmosphere><learning environment><lectures><life course><malignancy><medical college><medical schools><member><metabolism disorder><metabolome><metabonome><metagenome><microbiome analysis><multidisciplinary><multimedia learning><neoplasm/cancer><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><next generation><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><on-line education><on-line learning><online education><online learning><pathophysiology><pathway><pediatric><pediatric cancer><pediatric care><pediatric department><pediatric health care><pediatric malignancy><pediatric patients><post-doc><post-doctoral><post-doctoral trainee><precision medicine><precision-based medicine><programs><recruit><research associates><scRNA sequencing><scRNA-seq><school atmosphere><school climate><school of medicine><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><technology-enhanced learning><tool><training achievement><training atmosphere><training level><training status><transcriptome><translation research><translational investigation><trend><undergrad><undergraduate><undergraduate student><university atmosphere><virtual learning><web-based instruction><web-based training><whole genome>
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Patrick Scott Hume

NATIONAL JEWISH HEALTH, DENVER, CO

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$158,328
FY 2026

Project Title

Interstitial macrophages in cigarette smoke-induced small airway remodeling

Grant Number:

5K08HL155894-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Project Summary: This proposal describes a 5-year research training program that will develop Dr. Patrick Hume into an independent basic and translational physician-scientist investigator. His long-term career goal is to advance the fields of COPD and macrophage biology through the ...

Research Terms

<92-kDa Gelatinase><92-kDa Type IV Collagenase><Address><Airway Disease><Alveolar Macrophages><Animal Model><Animal Models and Related Studies><Aorta><Award><Basic Research><Basic Science><Binding><Biology><Blood Circulation><Blood monocyte><Bloodstream><Board Certification><Body Tissues><CD44><CD44 gene><CLG4B><COPD><Cause of Death><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell-Extracellular Matrix><Cells><Cellular biology><Chronic><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Cicatrix><Cigarette><Cigarette Smoker><Closure by Ligation><Collagen><Critical Care><Data><Data Analyses><Data Analysis><Deposit><Deposition><Development><Development Plans><Doctor of Philosophy><Dropout><ECM><Embryo><Embryonic><Endothelium><Environment><Extracellular Matrix><Fellowship><Fibroblasts><Fibrosis><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><GELB><Gelatin><Gelatinase B><Goals><Health><Human><Hyaluronic Acid><Hyaluronic Acid Binding><Immunofluorescence><Immunofluorescence Immunologic><In Situ><Individual><Infiltration><Inflammation><Inflammatory><Injury><Institution><International><Intracellular Communication and Signaling><Investigators><Jewish><Jews><Laboratories><Lead><Leadership><Ligation><Link><Location><Lung><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Lymphatic function><MDU3><MMP-9><MMP-9 Protein><MMP9><MMP9 gene><MMPs><Macrophage><Macrophage Gelatinase><Marrow monocyte><Matrix Metalloproteinase-9><Matrix Metalloproteinases><Mediating><Medical Residency><Medicine><Mentors><Mentorship><Metallopeptidases><Metalloproteases><Metalloproteinases><Metalloproteins><Mice><Mice Mammals><Modern Man><Molecular Interaction><Molecular Weight><Murine><Mus><Myofibroblast><Mφ><NHLBI><National Heart, Lung, and Blood Institute><Pathogenesis><Pathologic><Pathology><Pb element><Pgp1><Ph.D.><PhD><Physicians><Play><Population><Production><Public Health><Publications><Pulmonary Macrophages><R-Series Research Projects><R01 Mechanism><R01 Program><RNA Seq><RNA sequencing><RNAseq><Receptor Protein><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Training><Researchers><Role><Scars><Scientific Publication><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Smoke><Smoker><Structure of parenchyma of lung><Surface><Terminal Bronchiole><Testing><Tissues><Training><Training Programs><Transgenic Animals><Transgenic Mice><Type V Collagenase><Work><Writing><airflow limitation><airflow obstruction><airway limitation><airway obstruction><airway remodeling><asthma model><biological signal transduction><career><career development><cell biology><chronic obstructive pulmonary disorder><cigarette smoke><cigarette smoke exposure><cigarette smoke-induced><cigarette smoking><cigarette use><data interpretation><design><designing><developmental><experience><exposure to cigarette smoke><flow cytophotometry><heavy metal Pb><heavy metal lead><in vitro Model><injuries><innovate><innovation><innovative><interstitial><lymph channel><lymph vessel><lymphatic channel><lymphatic vessel><model of animal><monocyte><morphometry><mouse model><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><obstructed airflow><obstructed airway><pulmonary><receptor><recruit><repair><repaired><respiratory airway obstruction><response><small airways disease><smoking-induced lung disease><smoking-related lung disease><social role><therapeutic target><transcriptome sequencing><transcriptomic sequencing><translational clinician><translational physician><undergrad><undergraduate><undergraduate student><uptake>
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Andrew D Spearman

MEDICAL COLLEGE OF WISCONSIN, MILWAUKEE, WI

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$150,552
FY 2026

Project Title

Investigation of hepatic factor in pulmonary arteriovenous malformations

Grant Number:

5K08HL157510-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY The proposed studies in this K08 application will use innovative approaches to investigate soluble vascular endothelial growth factor receptor 1 (sVEGFR1) as a critical regulator of pulmonary microvascular remodeling and inhibitor of pulmonary arteriovenous malformation (PAVM) develo...

Research Terms

<0-11 years old><Address><Animal Model><Animal Models and Related Studies><Animals><Arteries><Autoregulation><Binding><Biology><Blood><Blood Reticuloendothelial System><Blood Sample><Blood Serum><Blood Tests><Blood Vessels><Blood specimen><Body Tissues><Brain><Brain AVMs><Brain Nervous System><Cardiac Malformation><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Survival><Cell Viability><Cells><Cerebral Arteriovenous Malformations><Child><Child Youth><Children (0-21)><Circulation><Clinical><Clinical Skills><Co-culture><Cocultivation><Coculture><Coculture Techniques><Collaborations><DNA Molecular Biology><Development><Diffuse><Encephalon><Endothelial Cells><FLT VEGF Receptor><FLT1 RTK><FLT1 Receptor Tyrosine Kinase><Failure><Flt-1><Future><Gene Expression><Goals><Heart Malformation><Hematologic Tests><Hematological Tests><Hematology Testing><Hepatic><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><Homeostasis><Hypoxia><Hypoxic><In Vitro><Incubated><Institution><Intracellular Communication and Signaling><Investigation><Investigators><Isoforms><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Knowledge><Left><Ligands><Liver><Liver Cells><Lung><Lung Respiratory System><Mediating><Medical><Membrane><Mice><Mice Mammals><Microscopic><Modernization><Molecular Biology><Molecular Interaction><Murine><Mus><NGS Method><NGS system><Null Mouse><Operative Procedures><Operative Surgical Procedures><Oxygen Deficiency><Pathologic><Pathologic Angiogenesis><Pathologic Neovascularization><Pathological Angiogenesis><Pathological Neovascularization><Patient Care><Patient Care Delivery><Patients><Perfusion><Physicians><Physiologic><Physiological><Physiological Homeostasis><Physiology><Position><Positioning Attribute><Prevention><Protein Isoforms><Proteins><Proteomics><Proto-Oncogene Protein flt><Publishing><Pulmonary AVMs><QOL><Quality of life><RNA Seq><RNA Splicing><RNA sequencing><RNAseq><Receptor Tyrosine Kinase,Class V><Research Personnel><Researchers><Risk><Role><Sampling><Science><Scientist><Serum><Signal Transduction><Signal Transduction Systems><Signaling><Slice><Source><Splicing><Structural defect><Structural malformation><Superior Vena Cava><Superior vena cava structure><Surgical><Surgical Interventions><Surgical Procedure><Techniques><Testing><Tissues><Training><Transgenic Animals><Tyrosine Protein Kinase FRT><Tyrosine Protein Kinase Receptor FLT><VEGF><VEGF Receptor flt-1 Protein><VEGFR-1><VEGFR1><VEGFs><Vascular Endothelial Cell><Vascular Endothelial Growth Factor Receptor-1><Vascular Endothelial Growth Factors><Vascular remodeling><Veins><Walking><abnormal heart development><angiogenesis><biological signal transduction><brain arteriovenous malformations><care for patients><care of patients><career development><caring for patients><congenital cardiac abnormality><congenital cardiac anomalies><congenital cardiac disease><congenital cardiac disorder><congenital cardiac malformation><congenital heart abnormality><congenital heart anomaly><congenital heart disease><congenital heart disorder><congenital heart malformation><developmental><exercise capacity><experience><fms-Like Tyrosine Kinase><hepatic body system><hepatic organ system><hepatic vein><improved><in vivo><inhibitor><innovate><innovation><innovative><kids><lung AVMs><lung microvascular endothelial cells><lung vascular endothelial cells><membrane structure><model of animal><mouse genetics><next gen sequencing><next generation sequencing><nextgen sequencing><palliate><palliation><prevent><preventing><pulmonary><pulmonary arteriovenous malformation><pulmonary microvascular endothelial cells><pulmonary vascular endothelial cells><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><structural abnormalities><structural anomalies><surgery><tool><transcriptome sequencing><transcriptomic sequencing><transcriptomics><vascular><vascular abnormality><vascular bed><youngster>
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Laura C Alonso

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Good lead · 48/100
Training-friendly
Very recent
Active award
$143,056
FY 2026

Project Title

Research Training in Endocrinology and Metabolism

Grant Number:

5T32DK131957-04

Activity Code:

T32

Mechanism:

Training, Institutional

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY This proposed postdoctoral training program (2 fellows/year, 2-year program) in endocrinology and metabolism will provide comprehensive research training for individuals with a serious commitment to a career at the interface of biomedical research and endocrine disorders. Metabolic d...

Research Terms

<Endocrinology><Metabolism and Endocrinology><Research Training>
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Daniel C. Peltier

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$101,844
FY 2026

Project Title

Long noncoding RNA-mediated regulation of T-cell alloimmunity

Grant Number:

5K08HL157619-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Abstract The goal of this K08 proposal is to provide didactic and experiential training in new techniques needed to achieve my long-term career goal of developing an independent research program exploring the novel intersection of long noncoding RNAs (lncRNA) and alloimmunity. The proposed ...

Research Terms

<Acute><Acute GVHD><Acute Graft Versus Host Disease><Allogenic><Animal Model><Animal Models and Related Studies><Area><Assay><Binding><Bioassay><Bioinformatics><Biological Assay><Biology><Blood Diseases><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Function><Cell Nucleus><Cell Physiology><Cell Process><Cell Signaling><Cell-Mediated Lympholytic Cells><Cells><Cellular Function><Cellular Physiology><Cellular Process><Clinical><Co-Stimulator><Complication><Costimulator><Cytolytic T-Cell><Cytoplasm><Cytotoxic T Cell><Cytotoxic T-Lymphocytes><Data><Data Set><Development Plans><Enhancers><Epidermal Thymocyte Activating Factor><FBJ osteosarcoma oncogene><FOS gene><Faculty><Functional RNA><G0S7><Gene Expression><Gene Transcription><Genetic Transcription><Goals><Grant><GvHD><HSC transplantation><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Homologous Wasting Disease><Human><IL-2><IL2 Protein><Immune response><Immunology><In Vitro><Interleukin 2><Interleukin 2 Precursor><Interleukin II><Interleukin-2><Interleukine 2><Interleukine 2 Precursor><Interleukine II><Intracellular Communication and Signaling><Investigators><Laboratories><Learning><Lymphocyte Mitogenic Factor><MHC Receptor><Major Histocompatibility Complex Receptor><Measures><Mediating><Mentors><Mentorship><Methods><Mice><Mice Mammals><Mitogenic Factor><Modern Man><Molecular><Molecular Genetics><Molecular Interaction><Murine><Mus><NGS Method><NGS system><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Nucleus><Outcome><Patients><Physicians><Production><Proteins><Protooncogene FOS><RNA><RNA Binding><RNA Expression><RNA Gene Products><RNA Seq><RNA and protein interaction><RNA bound><RNA sequencing><RNA-Protein Interaction><RNAseq><Receptor Signaling><Regulatory T-Lymphocyte><Research><Research Personnel><Researchers><Ribonucleic Acid><Role><Runt Disease><Sampling><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Subcellular Process><System><T cell differentiation><T cell growth factor><T cell regulation><T cell response><T-Cell Activation><T-Cell Antigen Receptors><T-Cell Growth Factor><T-Cell Proliferation><T-Cell Receptor><T-Cell Stimulating Factor><T-Cells><T-Lymphocyte><Techniques><Testing><Th-1 Cell><Th1 Cells><Thymocyte Stimulating Factor><Tissues><Training><Training Programs><Transcription><Transplant immunology><Transplantation Immunology><Treg><Type 1 Helper Cell><Untranslated RNA><Work><Writing><activate T cells><acute graft vs host disease><acute graft vs. host disease><alloimmunity><biological signal transduction><blood disorder><blood stem cell transplantation><c fos><c-fos Gene><c-fos Proto-Oncogenes><career><career development><cell killing><cohort><curative intervention><curative therapeutic><curative therapy><curative treatments><cytokine><cytotoxic><cytotoxic CD8 T cells><cytotoxic CD8 T lymphocyte><differential expression><differentially expressed><disease model><disorder model><gastrointestinal><graft versus host disease><graft vs host disease><graft vs. host disease><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><high risk><host response><immune system response><immunoresponse><improved><in vivo><isoimmunity><killer T cell><model of animal><mouse model><murine model><next gen sequencing><next generation sequencing><nextgen sequencing><noncoding><novel><programs><regulatory T-cells><response><social role><thymus derived lymphocyte><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog>
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Shillpa Naavaal

VIRGINIA COMMONWEALTH UNIVERSITY, RICHMOND, VA

Good lead · 46/100
Training-friendly
Solid budget
Active award
Career award
$483,924
FY 2025

Project Title

The Role of Comprehensive Adult Medicaid Dental Benefit in Improving and Advancing Oral Health among Adults and Children

Grant Number:

4K08DE032443-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/19/2023

End Date:

8/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Even though it is well established that oral health is integral to overall health, economic productivity, and well-being, it remains the most common unmet health need in the US. Low-income individuals carry a significantly high burden of dental disease, highlighting a lack of access to oral health c...

Research Terms

<0-11 years old><21+ years old><Access to Care><Accident and Emergency department><Address><Adult><Adult Human><Advisory Committees><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Child><Child Health><Child Youth><Children (0-21)><Clinical Investigator Award><Communities><Complex><Comprehensive Dental Care><County><Data><Data Science><Data Set><Data Sources><Dental><Dental Care><Dental Care for Children><Dental Procedure><Dental Scaling><Dentistry for Children><Development><Development Plans><ED visit><ER visit><Economics><Emergencies><Emergency Department><Emergency Situation><Emergency care visit><Emergency department visit><Emergency hospital visit><Emergency room><Emergency room visit><Enrollment><Ensure><Environment><Face><Family><Fostering><Foundations><Goals><Health><Health Benefit><Health Care><Health Policy><Health Services><Health Services Accessibility><Health Services Evaluation><Health Services Research><Individual><Institution><Insurance><Interruption><Investigators><K-Awards><K-Series Research Career Programs><K08 Mechanism><K08 Program><Knowledge><Laws><Link><Low Income Population><Low income group><Measures><Medicaid><Medical Care Research><Mentors><Mentorship><Methods><Mission><Mouth Diseases><NIDCR><NIDR><National Institute of Dental Research><National Institute of Dental and Craniofacial Research><Natural experiment><Oral Cavity Disease><Oral Cavity Disorder><Oral Disease><Oral Disorder><Oral health><Outcome><Outcomes Research><Parents><Personal Satisfaction><Policies><Policy Research><Population><Preventative service><Preventive><Preventive service><Privatization><Productivity><Quasi-experiment><Quasi-experimental analysis><Quasi-experimental approach><Quasi-experimental design><Quasi-experimental methods><Quasi-experimental research><Quasi-experimental study><Quasi-experimental technique><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Career Program><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Research Support><Researchers><Resources><Role><Rural><SCHIP><Savings><Series><Service delivery model><Service model><Services><Sight><Solid><Source><State Children's Health Insurance Program><Structure><Task Forces><Time><Tooth Diseases><Tooth Disorder><Training><Underinsured><Uninsured><Urbanicity><Virginia><Vision><Visit><Work><access to health services><access to services><access to treatment><accessibility to health services><adulthood><advisory team><analytical method><availability of services><care access><care delivery model><care utilization><career><career development><complex data><cost><dental disease><dental disorder><dental health><dental service><developmental><econometrics><economic><enroll><evidence base><experience><faces><facial><federal poverty level><health care delivery model><health care policy><health service access><health services availability><improved><insight><kids><low income individual><low income people><mouth disorder><multidisciplinary><parent><programs><service availability><service utilization><services research><skill acquisition><skill development><skills><social factors><social role><success><treatment access><treatment services><visual function><well-being><wellbeing><youngster>
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Jon R Wisler

OHIO STATE UNIVERSITY, Columbus, OH

Good lead · 46/100
Likely hiring
Solid budget
Active award
$393,750
FY 2025

Project Title

Analyzing the long-term effects of DNA methylation meditated immunosuppression following sepsis

Grant Number:

5R35GM150968-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/10/2023

End Date:

7/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

This proposal is for a five-year research program for Dr. Jon Wisler, an Assistant Professor in the Division of Trauma, Critical Care, and Burn Surgery. This proposal studies the mechanistic events and immunosuppressive clinical consequences of epigenetic methylation events that occur in survivors o...

Research Terms

<Area><Cellular Immune Function><Clinical><Clinical Investigator Award><Coupled><Couples><Critical Care><DNA Methylation><DNA Methyltransferase><DNA Modification Methylases><DNA Modification Methyltransferases><DNA-Methyltransferases><Data><Diagnosis><Disease><Disorder><Dnmt><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Event><Exhibits><Gene Inactivation><Gene Silencing><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immunochemical Immunologic><Immunologic><Immunologic Diseases><Immunological><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Immunologically><Immunologics><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><In Vitro><Infection><Intervention><Investigation><Investigators><K08 Mechanism><K08 Program><Knowledge><Laboratories><Long-Term Effects><Mediating><Meditation><Mental Depression><Methylation><Modification Methylases><Molecular><NIH><National Institutes of Health><Operative Procedures><Operative Surgical Procedures><Outcome><Outcome Measure><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phase><Process><Productivity><Psychosocial Effect><QOL><Quality of life><Recovery><Regulation><Research><Research Personnel><Researchers><Sepsis><Site-Specific DNA-methyltransferase><Surgical><Surgical Interventions><Surgical Procedure><Survivors><Time><Trauma><Treatment/Psychosocial Effects><United States National Institutes of Health><after sepsis><after septic><biopsychosocial><clinical effect><decline in function><decline in functional status><depression><direct application><disability><epigenetic regulation><epigenetically><following sepsis><following septic><functional decline><functional outcomes><functional status decline><human data><immune function><immune suppression><immune suppressive activity><immune suppressive function><immunosuppressive activity><immunosuppressive function><immunosuppressive response><improved><in vivo><individuals with sepsis><innate immune function><insight><measurable outcome><mortality><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><outcome measurement><patient oriented outcomes><patients with sepsis><people with sepsis><pharmacologic><post sepsis><post septic><professor><programs><psychosocial outcome><psychosocial sequelae><response><restoration><sepsis groups><sepsis patients><sepsis population><sepsis subjects><sepsis survivor><sepsis survivorship><septic group><septic individuals><septic patients><septic people><septic population><septic subject><septic survival><septic survivor><skills><subjects with sepsis><surgery><survive sepsis><synergism><therapeutic evaluation><therapeutic testing><transcriptional silencing>
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Srivatsan Raghavan

DANA-FARBER CANCER INST, BOSTON, MA

Good lead · 46/100
Training-friendly
Solid budget
Active award
Career award
$301,496
FY 2025

Project Title

Regulation and targeting of tumor cell states and plasticity in pancreatic cancer

Grant Number:

5K08CA260442-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2022

End Date:

8/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract: Metastatic pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal malignancy with few therapeutic options. Tumor transcriptional states are strongly correlated with therapeutic responses and clinical outcomes in PDAC. However, the mechanisms that regulate PDAC ...

Research Terms

<1-Phosphatidylinositol 3-Kinase><Address><Adopted><Advanced Development><Advisory Committees><Area><Award><Basal Cell><Basal Cell Cancer><Biological Markers><Biomedical Engineering><Biopsy><Bone-Derived Transforming Growth Factor><C-jun Amino-Terminal Kinase><C-jun Kinase-1><C-jun N-Terminal Kinase 1><CRISPR><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas system><CRISPR/Cas9 screen><CSAID-Binding Protein 1><CSAID-Binding Protein 2><CSBP2><Cancer Biology><Cancers><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chemoresistance><Cholangiocarcinoma><Cholangiocellular Carcinoma><Chronic><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats><Committee Members><Cytokine-Suppressive Antiinflammatory Drug-Binding Protein 1><Cytokine-Suppressive Antiinflammatory Drug-Binding protein 2><DF/HCC><DPC4><Dana-Farber Cancer Institute><Deleted in Pancreatic Carcinoma><Development and Research><Disease><Disorder><Drosophila Homolog of Mothers Against Decapentaplegic 4><Drug resistance><Environment><Evolution><Exhibits><Extracellular Signal-Regulated Kinase Gene><Faculty><GI cancers><GI malignancies><GI tract cancers><Gastrointestinal Cancer><Gastrointestinal Tract Cancer><Gene Transcription><Genetic><Genetic Screening><Genetic Transcription><Goals><Heterogeneity><Immune><Immunes><Infrastructure><Inpatients><Intracellular Communication and Signaling><Investigators><JN Kinase><JNK><JNK Mitogen-Activated Protein Kinases><JNK1><JNK1 Kinase><JNK1 protein><JNK1A2><JNK21B1/2><JV18><JV18-1><Knock-out><Knockout><Laboratories><Libraries><Ligands><MADH2><MADH2 gene><MADH4><MADH4 gene><MADR2><MAP Kinase 8><MAP Kinase 8 Gene><MAP Kinase Gene><MAP kinase kinase kinase 7><MAP3K7><MAP3K7 gene><MAPK><MAPK14><MAPK14 Mitogen-Activated Protein Kinase><MAPK14 gene><MAPK8><MAPK8 Mitogen-Activated Protein Kinase><MAPK8 gene><Malignant Gastrointestinal Neoplasm><Malignant Neoplasms><Malignant Pancreatic Neoplasm><Malignant Tumor><Malignant neoplasm of gastrointestinal tract><Malignant neoplasm of pancreas><Mediating><Medical Oncologist><Mentors><Mentorship><Milk Growth Factor><Mitogen-Activated Protein Kinase 14><Mitogen-Activated Protein Kinase 8><Mitogen-Activated Protein Kinase Gene><Modeling><Molecular><Mxi2><Oncology><Oncology Cancer><Organoids><Out-patients><Outcome><Outpatients><PDA model><PDAC Model><PDAC cancer cell><PDAC cell><PI-3 Kinase><PI3-Kinase><PI3CG><PI3KGamma><PI3k><PIK3><PIK3CG><PIK3CG gene><PRKM8><Pancreas Cancer><Pancreas Ductal Adenocarcinoma><Pancreatic Cancer><Pancreatic Ductal Adenocarcinoma><Patient Care><Patient Care Delivery><Patients><Phenotype><Phosphatidylinositol 3-Kinase><Phosphatidylinositol-3-OH Kinase><Phosphoinositide 3-Hydroxykinase><Physicians><Platelet Transforming Growth Factor><Prognosis><PtdIns 3-Kinase><R & D><R&D><RNA Expression><Receptor Protein><Regulation><Research><Research Personnel><Research Proposals><Researchers><Resistance><Role><SAP Kinase-1><SAPK/JNK><SAPK1 Mitogen-Activated Protein Kinase><SAPK1/JNK><SAPK2A><SMA- and MAD-Related Protein 4><SMAD2><SMAD4><Sampling><Scientific Advances and Accomplishments><Scientist><Selection for Treatments><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Specific qualifier value><Specified><Stress-Activated Protein Kinase 2A><Stress-Activated Protein Kinase JNK1><Stress-Activated Protein Kinase gamma><TAK1><TAK1a><TAK1b><TAK1c><TAK1d><TGF B><TGF Beta Signaling Pathway><TGF-Beta Activated Kinase 1><TGF-beta><TGF-beta-activated kinase 1><TGF-β><TGF-β Signaling Pathway><TGFbeta><TGFβ><Task Forces><Techniques><Testing><Therapeutic><Time><Training><Transcription><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Tumor Cell><Type I Phosphatidylinositol Kinase><Type III Phosphoinositide 3-Kinase><Variant><Variation><Work><advisory team><biliary cancer><bio-engineered><bio-engineers><bio-markers><bioengineering><biologic marker><biological engineering><biological signal transduction><biomarker><c-jun N-Terminal Kinase><cancer microenvironment><care for patients><care of patients><career development><caring for patients><chemoresistant><chemotherapeutic agent><chemotherapeutic compounds><chemotherapeutic drugs><chemotherapeutic medications><chemotherapy><chemotherapy resistance><chemotherapy resistant><cholangiosarcoma><clustered regularly interspaced short palindromic repeats screen><drug resistant><drug sensitivity><effective therapy><effective treatment><gastrointestinal malignancies><in vivo><insight><jun-NH2-Terminal Kinase><malignancy><medical college><medical schools><member><mitogen-activated protein kinase kinase kinase 7><neoplasm/cancer><neoplastic cell><non-genetic><nongenetic><overexpress><overexpression><p38><p38 MAP Kinase><p38 MAPK Gene><p38 Mitogen Activated Protein Kinase><p38 Protein Kinase><p38 SAPK><p38-Alpha><p38Alpha><pancreatic ductal adenocarcinoma cell><pancreatic ductal adenocarcinoma model><pancreatic malignancy><pharmacologic><predict clinical outcome><receptor><research and development><resistance mechanism><resistance to Drug><resistance to therapy><resistant><resistant mechanism><resistant to Drug><resistant to therapy><response to therapy><response to treatment><scRNA sequencing><scRNA-seq><school of medicine><scientific accomplishments><scientific advances><selection of treatment><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><stress-activated protein kinase 1><synergism><targeted agent><therapeutic agent development><therapeutic development><therapeutic resistance><therapeutic response><therapy resistant><therapy response><therapy selection><transforming growth factor-beta-activated kinase 1><treatment resistance><treatment response><treatment responsiveness><treatment selection><tumor><tumor microenvironment>
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Rebecca Anne Epperly

ST. JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN

Good lead · 46/100
Training-friendly
Solid budget
Active award
Career award
$289,937
FY 2025

Project Title

Hypofractionated radiation in combination with B7-H3-CAR T cells for pediatric patients with relapsed/refractory sarcomas

Grant Number:

1K08CA300913-01

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/20/2025

End Date:

7/31/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT My overarching career goal as a clinician scientist is to become an independent investigator, who develops novel cellular immune therapies to improve outcomes for pediatric patients with high-risk malignancies. This K08 application proposes a career development plan and rese...

Research Terms

<21 year old><21 years of age><21+ years old><Address><Adult><Adult Human><Antigen Targeting><Award><B7-H3><B7H3><Biometrics><Biometry><Biopsy><Biostatistics><Body Tissues><CAR T cell therapy><CAR T cells><CAR T therapy><CAR modified T cells><CAR-T><CAR-Ts><CD276><CD276 gene><Cancers><Cell Therapy><Cellular immunotherapy><Childhood><Childhood Cancers><Childhood Solid Neoplasm><Childhood Solid Tumor><Clinical><Clinical Research><Clinical Study><Clinical Trials><Clinical Trials Design><Collaborations><Combined Modality Therapy><Correlative Study><Coupled><Data><Dedications><Development Plans><Development and Research><Discipline><Disease><Disorder><Dose><Dose Limiting><Dose Rate><Early-Stage Clinical Trials><Effector Cell><Enrollment><Environment><Evaluation><Foundations><Funding><Future><Goals><Grant><Image><Immune><Immune infiltrates><Immune mediated therapy><Immune response><Immune system><Immunes><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologically Directed Therapy><Immunologics><Immunology procedure><Immunomodulation><Immunotherapy><Infrastructure><Infusion><Infusion procedures><Investigators><Knowledge><Laboratories><Lead><Leadership><Lesion><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Neoplasms><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant Soft Tissue Neoplasm><Malignant Tumor><Malignant childhood cancer><Mentors><Mentorship><Methods><Monitor><Multimodal Therapy><Multimodal Treatment><Oncology><Oncology Cancer><Outcome><Patients><Pb element><Pediatric Solid Tumor><Phase><Phase 1 Clinical Trials><Phase I Clinical Trials><Phase I Study><Population><Position><Positioning Attribute><R & D><R&D><Radiation><Radiation therapy><Radiotherapeutics><Radiotherapy><Records><Refractory><Regimen><Relapse><Research><Research Personnel><Researchers><Resistance><Role><Safety><Saint Jude><Saint Jude Children's Cancer Center><Saint Jude Children's Research Hospital><Sarcoma><Scientist><Site><Solid Neoplasm><Solid Tumor><St. Jude><St. Jude Children's Cancer Center><St. Jude Children's Research Hospital><St. Jude Children's Research Hospital Comprehensive Cancer Center><St.Jude Children's Cancer Center><St.Jude Children's Research Hospital><St.Jude Children's Research Hospital Comprehensive Cancer Center><Structure><T cells for CAR><T-Cells><T-Lymphocyte><Technical Expertise><Techniques><Time><Tissues><Toxic effect><Toxicities><Training><Translating><Translations><adulthood><age 21><age 21 years><cancer in a child><cancer in children><cancer microenvironment><career><career development><cell based intervention><cell mediated intervention><cell mediated therapies><cell-based immunotherapy><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><chemotherapy><child patients><child with cancer><childhood malignancy><chimeric antigen T cell receptor><chimeric antigen receptor (CAR) T cell therapy><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cell therapy><chimeric antigen receptor T cells><chimeric antigen receptor T therapy><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><clinical translation><clinically translatable><cohort><combination therapy><combined modality treatment><combined treatment><cytokine><design><designing><early clinical trial><early phase clinical trial><enroll><epigenetic profiling><experience><heavy metal Pb><heavy metal lead><high risk><host response><imaging><immune cell infiltrate><immune cell therapy><immune modulation><immune regulation><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunologic assay><immunologic assay/test><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><improved><improved outcome><in vivo><infusions><innovate><innovation><innovative><malignancy><malignant soft tissue tumor><manufacture><multi-modal therapy><multi-modal treatment><neoplasm/cancer><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pediatric><pediatric cancer><pediatric malignancy><pediatric patients><phase 1 study><phase I protocol><pre-clinical><preclinical><prospective><radiation treatment><research and development><resistance mechanism><resistant><resistant mechanism><response><safety and feasibility><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><technical skills><thymus derived lymphocyte><translation><treatment strategy><treatment with radiation><tumor><tumor microenvironment><twenty-one year old><twenty-one years of age>
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Aimee C. Talleur

ST. JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN

Good lead · 46/100
Training-friendly
Solid budget
Active award
Career award
$289,458
FY 2025

Project Title

Improving CAR T-cell therapy for Pediatric B-cell Acute Lymphoblastic Leukemia (B-ALL)

Grant Number:

5K08CA279927-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2024

End Date:

8/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY My long-term career goal is to develop an independent research program focused on evaluation of novel cellular therapies designed to improve long-term outcomes for pediatric patients with high-risk malignancies. This K08 application describes a career development plan and research pr...

Research Terms

<21 year old><21 years of age><Acute B-Lymphocytic Leukemia><Address><Allogenic><Antigen Targeting><Antigens><Area><Assay><Autologous><Award><B Cell Childhood Acute Lymphocytic Leukemia><B Cell Pediatric Acute Lymphocytic Leukemia><B blood cells><B cell><B cell progenitor acute lymphoblastic leukemia><B cells><B-ALL><B-Cell Acute Lymphocytic Leukemia><B-Cell Acute Lymphoblastic Leukemia><B-Cell Antigen CD22><B-Cell Childhood ALL><B-Cell Childhood Acute Lymphoblastic Leukemia><B-Cell Childhood Acute Lymphogenous Leukemia><B-Cell Childhood Acute Lymphoid Leukemia><B-Cell Lymphoblastic Leukemia><B-Cell Pediatric ALL><B-Cell Pediatric Acute Lymphoblastic Leukemia><B-Cell Pediatric Acute Lymphogenous Leukemia><B-Cell Pediatric Acute Lymphoid Leukemia><B-Cells><B-Lymphocytes><B-cell><B-cell ALL><B-cell precursor acute lymphoblastic leukemia><B3 antigen><Bioassay><Biological Assay><Biometrics><Biometry><Biostatistics><CAR T cell therapy><CAR T cells><CAR T therapy><CAR modified T cells><CAR-T><CAR-Ts><CD19><CD19 gene><CD22><CD22 antigen><CD22 gene><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancers><Cas nuclease technology><Cell Count><Cell Number><Cell Therapy><Cellular biology><Characteristics><Childhood Precursor B Lymphoblastic Leukemia><Clinical><Clinical Investigator><Clinical Protocols><Clinical Research><Clinical Study><Clinical Trials><Clinical Trials Design><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><Correlative Study><DNMT3a><Data><Dedications><Development><Development Plans><Development and Research><Disease><Disease remission><Disorder><Donor Lymphocyte Infusion><Dose><Early-Stage Clinical Trials><Educational workshop><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Evaluation><Failure><Frequencies><Future><Gene Modified><Genes><Genetic><Goals><Grant><GvHD><HSC transplantation><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Homologous Wasting Disease><Immune mediated therapy><Immunologically Directed Therapy><Immunology><Immunotherapy><Infusion><Infusion procedures><Investigators><Knock-out><Knockout><Knowledge><Lead><Leadership><Lymphocyte Count><Lymphocyte Number><Malignant Hematologic Neoplasm><Malignant Neoplasms><Malignant Tumor><Maximal Tolerated Dose><Maximally Tolerated Dose><Maximum Tolerated Dose><Measures><Mentors><Mentorship><Modification><Molecular Analysis><Outcome><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pb element><Phase><Phase 1 Clinical Trials><Phase I Clinical Trials><Phase I Study><Phenotype><Pre-B-Cell Leukemia><Pre-Clinical Model><Preclinical Models><Precursor B Lymphoblastic Leukemia><Prevention><Prior Chemotherapy><Prior Chemotherapy Regimens><Production><Proliferating><R & D><R&D><Refractory><Relapse><Remission><Research><Research Design><Research Methodology><Research Methods><Research Personnel><Research Proposals><Researchers><Risk><Runt Disease><SIGLEC2><Safety><Severities><Sialic Acid-Binding Immunoglobulin-Like Lectin 2><Structure><Study Type><T cells for CAR><T memory cell><T-Cells><T-Lymphocyte><Technology><Testing><Therapeutic><Time><Total Lymphocyte Count><Training><Translating><Translations><Tumor Burden><Tumor Load><Variant><Variation><Work><Workshop><Writing><age 21><age 21 years><antileukemic activity><blood stem cell transplantation><burden of disease><burden of illness><career><career development><cell based intervention><cell biology><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><chemotherapy><child patients><chimeric antigen T cell receptor><chimeric antigen receptor><chimeric antigen receptor (CAR) T cell therapy><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cell therapy><chimeric antigen receptor T cells><chimeric antigen receptor T therapy><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><clinical investigation><cytokine><design><designing><determine efficacy><developmental><disease burden><disease risk><disorder risk><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><epigenetic profiling><epigenetically><evaluate efficacy><examine efficacy><exhaustion><experience><fitness><gene modification><genetically modified><graft versus host disease><graft vs host disease><graft vs. host disease><hDNA methyltransferase 3a><heavy metal Pb><heavy metal lead><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><high risk><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunogen><improved><in vivo><infusions><insight><intervention design><investigator-initiated trial><leukemia><malignancy><memory T lymphocyte><minimal risk><neoplasm/cancer><new approaches><next generation><novel><novel approaches><novel strategies><novel strategy><patient oriented outcomes><pediatric patients><phase 1 study><phase I protocol><pre-clinical><preclinical><programs><relapse patients><research and development><research and methods><risk minimization><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><study design><therapy design><thymus derived lymphocyte><translation><treatment design><tumor><twenty-one year old><twenty-one years of age>
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Daniel R Richardson

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 46/100
Training-friendly
Solid budget
Active award
Career award
$285,049
FY 2025

Project Title

Developing a Values Elicitation Tool to Improve Treatment Decision-Making in Acute Myeloid Leukemia

Grant Number:

5K08CA273684-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/11/2024

End Date:

5/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT This NCI K08 Mentored Career Development Award will prepare Dr. Daniel Richardson to become an independent R01-level investigator in patient-centered cancer care delivery for patients with acute myeloid leukemia (AML). AML treatment paradigms are changing for older patients....

Research Terms

<21+ years old><AML - Acute Myeloid Leukemia><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Address><Adult><Adult Human><Advocate><Assess implementation><Award><Back><Care Givers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caregivers><Client><Clinical><Collaborations><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Data><Decision Making><Development><Diagnosis><Doctor of Philosophy><Dorsum><Equipoise><Future><Generalized Growth><Goals><Growth><Hospitals><Implementation assessment><Intervention><Interview><Investigators><K-Awards><K-Series Research Career Programs><Maps><Measures><Mentors><Mentorship><Methodology><Methods><Newly Diagnosed><Oncologist><Oncology><Oncology Cancer><Outcome><Outcome Measure><Participant><Patient Care><Patient Care Delivery><Patients><Ph.D.><PhD><Process><QOL><Quality of life><Randomized><Recommendation><Reporting><Research><Research Career Program><Research Personnel><Research Resources><Researchers><Resources><Risk><Services><Survey Instrument><Surveys><System><Theoretical Domains framework><Time><Tissue Growth><Training><Work><acute granulocytic leukemia><acute myeloid leukemia><adulthood><aged><assess effectiveness><cancer care><care as usual><care delivery><care for patients><care of patients><career><caring for patients><clinical practice><design><designing><determine effectiveness><determine efficacy><developmental><digital><drug development><effectiveness assessment><effectiveness evaluation><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><elderly patient><evaluate effectiveness><evaluate efficacy><evaluate implementation><evaluation of implementation><examine effectiveness><examine efficacy><experience><group intervention><implementation determinants><implementation evaluation><implementation factors><implementation framework><implementation measures><implementation research framework><implementation science><implementation science framework><implementation strategy><improved><innovate><innovation><innovative><leukemia><leukemia treatment><leukemic therapy><measurable outcome><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><older adult><older adulthood><older patient><ontogeny><outcome measurement><patient centered><patient oriented><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><pilot trial><preference><primary outcome><randomisation><randomization><randomly assigned><recruit><response><shared decision making><strategies for implementation><success><support tools><tool><treatment as usual><trial design><usual care>
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Yinin Hu

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 46/100
Training-friendly
Solid budget
Active award
Career award
$279,606
FY 2025

Project Title

Preference-Based Treatment Valuation in Low-Risk Thyroid Cancer

Grant Number:

5K08CA293167-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/17/2024

End Date:

6/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Summary/Abstract: This Career Development Award (K08) establishes health state utilities across several established and evolving therapies for low-risk, sub-centimeter thyroid cancer (papillary thyroid microcarcinoma, PTMC). While survival for PTMC is favorable, its treatment can incur substantial m...

Research Terms

<21+ years old><Ablation><Active Follow-up><Address><Adult><Adult Human><Adverse effects><Affect><After Care><After-Treatment><Aftercare><Baltimore><Benign><Biometrics><Biometry><Biostatistics><Cancer Survivor><Carcinoma><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Cessation of life><Clinical><Clinical Research><Clinical Study><Consensus><Cost Effectiveness Analysis><Counseling><Cross Sectional Analysis><Cross-Sectional Analyses><Cross-Sectional Studies><Cross-Sectional Survey><Data><Death><Disease><Disease Frequency Surveys><Disorder><Doctor of Philosophy><Education><Educational Achievement><Educational Status><Educational aspects><Endocrine Gland Secretion><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiology Research><Epithelial cancer><Familiarity><Fellowship><General Population><General Public><Guidelines><Health><Health Care Providers><Health Care Technology><Health Personnel><Health Policy><Health Services Evaluation><Health Services Research><Health Technology><Hormones><Hypocalcemia><K-Awards><K-Series Research Career Programs><Knowledge><Malignant Epithelial Neoplasms><Malignant Epithelial Tumors><Malignant Thyroid Gland Neoplasm><Malignant Tumor of the Thyroid><Malignant Tumor of the Thyroid Gland><Malignant neoplasm of thyroid><Maryland><Master of Science><Master's Degree><Math Models><Measures><Medical Care Research><Mentors><Methodology><Methods><Modeling><Monitor><Morbidity><Morbidity - disease rate><Muscle Paresis><Muscular Paresis><Operative Procedures><Operative Surgical Procedures><Papillary><Paresis><Participant><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Perception><Persons><Ph.D.><PhD><Pharmacy Schools><Physicians><Pilot Projects><Policies><Position><Positioning Attribute><Process><Prognosis><Publishing><RF ablation><Radio Frequency Ablation><Radiofrequency Ablation><Radiofrequency Interstitial Ablation><Research><Research Career Program><Research Resources><Resource Allocation><Resources><Respondent><Risk><Series><Societies><Specialist><Supplementation><Surgical><Surgical Interventions><Surgical Oncology><Surgical Procedure><Survey Instrument><Surveys><Survivors><Technology Assessment><Testing><Therapeutic Hormone><Thyroid><Thyroid Cancer><Thyroid Diseases><Thyroid Gland><Thyroid Gland Disease><Thyroid Gland Disorder><Thyroid Head and Neck><Thyroidectomy><Time><Training><Treatment Cost><United States><Universities><Vocal Fold><active followup><adulthood><career development><cognitive burden><cognitive load><cohort><comparative cost effectiveness><compare cost effectiveness><cost><cost effective><cost effectiveness><cost efficient analysis><cost-effective analysis><design><designing><educational level><epidemiologic investigation><epidemiology study><epithelial carcinoma><experience><follow up><follow-up><followed up><followup><health care personnel><health care policy><health care worker><health economics><health provider><health workforce><improved><instrument><mathematic model><mathematical model><mathematical modeling><medical college><medical personnel><medical schools><oncologic surgery><paretic><paretic muscle><pathway><patient oriented outcomes><pilot study><post treatment><preference><professor><school of medicine><services research><societal costs><surgery><thyroid disorder><time use><training achievement><training level><training status><treatment provider><treatment strategy><vocal cord><volunteer>
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Leah Marie Marcotte

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 46/100
Training-friendly
Solid budget
Active award
Career award
$278,494
FY 2025

Project Title

Promoting patient portal use among Black women to lower barriers to breast cancer screening

Grant Number:

1K08CA293156-01A1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2025

End Date:

7/31/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract This K08 award will support the training and research experience needed for me to become an independent clinician investigator in the development and evaluation of interventions to address cancer screening inequities. I am an Assistant Professor of Medicine and primary care ...

Research Terms

<Academic Medical Centers><Address><Award><Black><Black Populations><Black group><Black individual><Black people><Black race><Blacks><Breast Cancer><Breast Cancer Detection><Breast cancer screening><Breast screening><Caring><Caucasian><Caucasian Females><Caucasian Race><Caucasian Women><Caucasians><Caucasoid><Caucasoid Race><Clinical effectiveness><Communities><Development><Devices><Disadvantaged><Economic Income><Economical Income><Effectiveness of Interventions><Eligibility><Eligibility Determination><Equity><Evaluation><Face><Foundations><Frequencies><Funding><Gender><Goals><Health Inequity><Health equity research><Health system><Improve Access><Income><Inequalities in Health><Inequities in Health><Inequity><Internet><Intervention><Interview><Investigators><Language><Lead><Left><Letters><Malignant Breast Neoplasm><Mammogram><Mammography><Medicine><Mentorship><Methods><NIH><National Institutes of Health><Occidental><Outcome><Patients><Pb element><Persons><Phase><Position><Positioning Attribute><Primary Care Physician><Protocol Screening><Race><Races><Racial Group><Randomization trial><Randomized><Research><Research Personnel><Research Resources><Research in health equity><Researchers><Resources><Schedule><Screening for cancer><Secure><Sister><Social status><Stage at Diagnosis><Testing><Training><Training Support><United States National Institutes of Health><Universities><University Medical Centers><WWW><Washington><White Females><White Women><Work><adaptive intervention><advocacy organizations><black female><black patient><black women><care as usual><career><cohort><community engaged participatory research><community engaged research><community partnered research><community partnership><community-engaged study><community-partnered study><culturally adapted intervention><culturally appropriate intervention><culturally centered intervention><culturally focused intervention><culturally informed intervention><culturally responsive intervention><culturally tailored intervention><death risk><design><designing><developmental><digital><digital access><digital accessibility><digital equality><digital equity><digital inclusion><early cancer detection><experience><faces><facial><health equity-focused research><health inequalities><heavy metal Pb><heavy metal lead><high risk><human centered design><implementation science><implementation/effectiveness><incomes><innovate><innovation><innovative><intersectionalities><intersectionality><intervention design><malignant breast tumor><mammary cancer detection><mammary screening><mammographic Imaging><mammographic examinations><mammographic exams><member><mortality><mortality risk><novel><outreach><participant interview><patient barriers><patient portal><patient-level barriers><primary outcome><professor><racial><racial background><racial origin><racial population><racial subgroup><randomisation><randomization><randomized trial><randomly assigned><research on health equity><research related to health equity><research to attain health equity><screening><screening cancer patients><screenings><secondary outcome><social position><social standing><therapy design><treatment as usual><treatment design><uptake><usual care><web><white race><world wide web>
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Kathryn Elizabeth Post

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 46/100
Training-friendly
Solid budget
Active award
Career award
$251,504
FY 2025

Project Title

A Nurse-Led, Coping and Supportive Care Intervention to Improve Psychosocial Outcomes of Patients with Triple-Negative Breast Cancer During the Transition from Curative Therapy to Surveillance

Grant Number:

5K08CA286755-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/17/2024

End Date:

6/30/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Patients with triple-negative breast cancer (TNBC) account for approximately 15% of all breast cancer diagnoses but are disproportionately burdened with metastatic disease and breast cancer death due to high rates of recurrence and a lack of risk-reducing treatment options in the surveillance phase....

Research Terms

<APN><ASCO><Address><Advanced Practice Nurse><Advisory Committees><American Cancer Society><American Society of Clinical Oncology><Anxiety><Attention><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biometrics><Biometry><Biostatistics><Breast Cancer><Breast Cancer Patient><Breast Oncology><Breast Tumor Patient><Cancer Survivor><Cancer Survivorship><Cancers><Caring><Cessation of life><Client satisfaction><Clinical><Cognition Therapy><Cognitive Psychotherapy><Cognitive Therapy><Cognitive treatment><Communities><Conditioning Therapy><Coping Skills><DNA mutation><Data><Death><Discipline of Nursing><Disease><Disorder><Distress><Doctor of Philosophy><ER Positive><ER+><ERBB2><ERBB2 gene><Education><Educational aspects><Emotional><Emotional well being><Endocrine Therapy><Enrollment><Estrogen receptor positive><Fear><Feedback><Feeling><Feels well><Fellowship><Five-Year Plans><Foundations><Fright><Funding><General Hospitals><Genetic Change><Genetic defect><Genetic mutation><Goals><HER -2><HER-2><HER2><HER2 Genes><HER2/neu><HR positive><Health Care Systems><High-Risk Cancer><Hormonal Therapy><International><Intervention><Interview><Investigators><Journals><Learning><Magazine><Malignant Breast Neoplasm><Malignant Neoplasms><Malignant Tumor><Massachusetts><Mentors><Mentorship><Methods><Modeling><Mutation><NEU Oncogene><NEU protein><Normal mental condition><Normal mental state><Normal psyche><Nurses><Nursing><Nursing Field><Nursing Profession><Oncogene ErbB2><Oncology><Oncology Cancer><Outcomes Research><Participant><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Patient Satisfaction><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Peer Review><Personal Satisfaction><Ph.D.><PhD><Phase><Pilot Projects><Population><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Prognosis><Protocol><Protocols documentation><Psychological Well Being><Publishing><QOL><QOL improvement><Quality of life><Questionnaires><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized, Controlled Trials><Recommendation><Recurrence><Recurrent><Recurrent Malignant Neoplasm><Recurrent Malignant Tumor><Reporting><Research><Research Associate><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Training><Researchers><Risk><Risk Reduction><Scientist><Sense of well-being><Stress and Coping><Structure><Supportive Therapy><Supportive care><Survival Rate><Survivors><Symptom Burden><TKR1><TNBC><Task Forces><Testing><Time><Training><Treatment Protocols><Treatment Regimen><Treatment Schedule><Uncertainty><Well in self><Woman><Work><acceptability and feasibility><advisory team><alleviate symptom><ameliorating symptom><behavior intervention><behavioral intervention><breast cancer diagnosis><c-erbB-2><c-erbB-2 Genes><c-erbB-2 Proto-Oncogenes><cancer care><cancer recurrence><care delivery><career development><clinical care><clinical significance><clinically significant><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><conference><convention><coping><coping strategy><coping with stress><curative intervention><curative therapeutic><curative therapy><curative treatments><decrease symptom><design><designing><develop therapy><doubt><emotional wellbeing><emotional wellness><enroll><erbB-2 Genes><evidence base><experience><feelings><fewer symptoms><genome mutation><group intervention><herstatin><high risk><high risk group><high risk individual><high risk people><high risk population><hormone receptor +><hormone receptor-positive><hormone therapy><improve symptom><improved><improved outcome><improvements in QOL><improvements in quality of life><individuals with breast cancer><innovate><innovation><innovative><instructor><intervention development><malignancy><malignant breast tumor><medical college><medical schools><meeting><meetings><mental well-being><mental wellbeing><mental wellness><multidisciplinary><neoplasm/cancer><neu Genes><nurse><patient oriented outcomes><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><patients with breast cancer><person with breast cancer><pilot study><pilot test><post-doc><post-doctoral><post-doctoral trainee><preference><prognostic><programs><psychological wellbeing><psychological wellness><psychosocial><psychosocial outcome><psychosocial sequelae><quality of life improvement><randomized control trial><reduce risk><reduce risks><reduce symptoms><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><relieves symptoms><research associates><risk stratification><risk-reducing><satisfaction><school of medicine><secondary outcome><self wellness><sense of wellbeing><skills><stratify risk><stress-related coping><summit><survivorship><symposia><symposium><symptom alleviation><symptom improvement><symptom reduction><symptom relief><symptomatic improvement><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapy development><treatment development><trial design><triple-negative breast cancer><triple-negative invasive breast carcinoma><usual care arm><usual care control group><well-being><wellbeing>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

RICHARD A. VAN ETTEN

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 44/100
Likely hiring
Active award
Team-scale grant
$70,000
FY 2025

Project Title

Clinical Trial Advancement and Development for Sarcomas

Grant Number:

3P30CA062203-27S1

Activity Code:

P30

Mechanism:

Research Centers

Agency:

NIH

Start Date:

9/11/1997

End Date:

1/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT Suitability. Dr. Harris is well-suited for the Early Career Cancer Clinical Investigator Award (ECIA). His clinical trial interests and career plans focus on optimizing outcomes with radiation therapy for sarcomas. Planned Activities. Clinical Trial Training. Dr. Harris will enroll in the S...

Research Terms

<American Cancer Society><Award><Awareness><CTEP><California><Cancer Therapy Evaluation Program><Cancers><Chemical Fractionation><Children's Hospital><Clinical Investigator Award><Clinical Trials><Collaborations><Communities><Community Outreach><County><Data><Development><Developmental Therapeutics><Developmental Therapeutics Program><Developmental Therapy><Education><Educational aspects><Educational workshop><Enrollment><FRACN><Fractionation><Fractionation Radiotherapy><Funding><Grant><Head><K08 Mechanism><K08 Program><Keytruda><Malignant Neoplasms><Malignant Soft Tissue Neoplasm><Malignant Tumor><Manuscripts><Mentors><Mentorship><Metastasis to the Lung><Metastatic Neoplasm to the Lung><Metastatic Tumor to the Lung><Monitor><NIH><National Clinical Trials Network><National Institutes of Health><Oranges><Outcome><Pediatric Hospitals><Persons><Phase><Phase 3 Clinical Trials><Phase III Clinical Trials><Protocol><Protocols documentation><Radiation><Radiation Oncology><Radiation therapy><Radiotherapeutics><Radiotherapy><Randomized><Research><Resectable><Role><SWOG><Safety><Sarcoma><Site><Southwest Oncology Group><Testing><Therapeutic><Training><United States National Institutes of Health><Universities><University of California Irvine Cancer Center><Work><Workshop><anti-cancer><cancers that are rare><career><clinical trial enrollment><community engagement><developmental><engagement with communities><enroll><high risk><interest><investigator-initiated trial><lung metastasis><malignancy><malignant soft tissue tumor><metastasize to the lung><neoplasm/cancer><pembrolizumab><phase III protocol><pulmonary metastasis><radiation treatment><randomisation><randomization><randomly assigned><rare cancer><rare malignancy><rare tumor><social role><treatment with radiation><trial enrollment><tumor><work group><working group>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Thomas James Lynch

FRED HUTCHINSON CANCER CENTER, SEATTLE, WA

Exploratory lead · 44/100
Likely hiring
Active award
Team-scale grant
$70,000
FY 2025

Project Title

CCSG Supplement: Early Career Cancer Clinical Investigator Award (ECIA)

Grant Number:

3P30CA015704-50S3

Activity Code:

P30

Mechanism:

Research Centers

Agency:

NIH

Start Date:

1/1/1997

End Date:

12/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Dr. Jonathan Sham is an early-career academic hepatopancreatobiliary (HPB) surgical oncologist with a focus on improving outcomes in patients with surgical diseases of the liver, pancreas, and biliary tree. He is heavily involved in the Fred Hutchinson Cancer Center (FHCC) and NCI clinical trial inf...

Research Terms

<ACRIN><American College of Radiology Imaging Network><American College of Surgeons><Bile Tract><Biliary System><Biliary Tree><CCSG><Cancer Center><Cancer Center Support Grant><Cancers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Clinical Cancer Center><Clinical Investigator Award><Clinical Trials><ECOG><Eastern Cooperative Oncology Group><Faculty><Foundations><GI cancers><GI malignancies><GI tract cancers><Gastrointestinal Cancer><Gastrointestinal Tract Cancer><Hepatic Disorder><Improve Access><Infrastructure><Joints><K-Awards><K-Series Research Career Programs><K08 Mechanism><K08 Program><Lead><Liver diseases><Malignant Gastrointestinal Neoplasm><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of gastrointestinal tract><Mentorship><Mission><Multi-center trial><Multicenter Trials><Oncologic Surgeon><Operative Procedures><Operative Surgical Procedures><Outcome><Palliative Care><Palliative Therapy><Palliative Treatment><Pancreatic Diseases><Pancreatic Disorder><Pancreatic Fistula><Patients><Pb element><Phase><Population><Position><Positioning Attribute><Postoperative><Postoperative Period><Prevention><Randomized><Research Career Program><Review Committee><Running><SWOG><Southwest Oncology Group><Surgical><Surgical Interventions><Surgical Oncologist><Surgical Procedure><System><Training><Work><biliary tract><cancer care><cancer clinical trial><career><comfort care><design><designing><gastrointestinal malignancies><heavy metal Pb><heavy metal lead><hepatic disease><hepatopathy><improved><improved outcome><liver disorder><malignancy><multidisciplinary><neoplasm/cancer><novel><oncology clinical trial><palliative intervention><pancreas disorder><programs><randomisation><randomization><randomly assigned><recruit><skills><surgery>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

WILLIAM George NELSON

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 44/100
Likely hiring
Active award
Team-scale grant
$65,105
FY 2025

Project Title

Regional Oncology Research Center (Early Career Cancer Clinical Investigator Award)

Grant Number:

3P30CA006973-62S5

Activity Code:

P30

Mechanism:

Research Centers

Agency:

NIH

Start Date:

5/7/1997

End Date:

5/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

The Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Johns Hopkins is dedicated to cancer research, education and training, and patient care, with the overarching goal of creating and applying new knowledge to improve prevention, screening, detection, diagnosis and treatment of cancer in Marylan...

Research Terms

<Age><Aging><Bone Marrow Grafting><Bone Marrow Transplant><Bone Marrow Transplantation><CCSG><Cancer Center Support Grant><Cancer Control><Cancer Control Science><Cancer Patient><Cancer Treatment><Cancers><Cardiac Diseases><Cardiac Disorders><Catchment Area><Cause of Death><Center for Cancer Research><Chemicals><Clinical Investigator Award><Clinical Research><Clinical Study><Clinical Trials><Communities><Comprehensive Cancer Center><Dedications><Defect><Detection><Diagnosis><Education and Training><Enrollment><Epidemiologic analysis><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Equipment and supply inventories><Functional Imaging><Funding><Future><Genetic><Genome><Goals><Health Care Professional><Health Care Systems><Health Professional><Heart Diseases><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><Human><Human Characteristics><Human Nature><Immune mediated therapy><Immunologically Directed Therapy><Immunotherapy><Incidence><Intervention><Intervention Studies><Intervention Trial><Interventional trial><Invaded><Inventory><Investigators><K08 Mechanism><K08 Program><Knowledge><Life><Life Expectancy><Life Style><Lifestyle><Malignant Cell><Malignant Hematologic Neoplasm><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Marrow Transplantation><Maryland><Medical><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Modern Man><Molecular><Molecular Genetics><NCI Center for Cancer Research><NCI Organization><National Cancer Institute><Neoplasm Metastasis><Oncogenesis><Oncology><Oncology Cancer><Outcome><Patient Care><Patient Care Delivery><Patients><Peer Review><Peer Review Grants><Physiologic Imaging><Population><Population Group><Prevention><Productivity><Publications><Research><Research Personnel><Research Specimen><Research Training><Researchers><Resource Sharing><Science><Scientific Publication><Scientist><Screening for cancer><Secondary Neoplasm><Secondary Tumor><Services><Specimen><Therapeutic Studies><Therapy Research><Training and Education><Translating><Underserved Population><United States><Universities><Work><ages><anti-cancer immunotherapy><anti-cancer research><anti-cancer therapy><anticancer immunotherapy><biomedical scientist><cancer care><cancer cell><cancer genetics><cancer imaging><cancer immunology><cancer immunotherapy><cancer metastasis><cancer prevention><cancer research><cancer therapy><cancer-directed therapy><care for patients><care of patients><career><career development><caring for patients><early cancer detection><enroll><epidemiologic evaluation><epigenetically><heart disorder><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based cancer therapies><immune-based therapies><immune-based treatments><immuno therapy><immunotherapy for cancer><immunotherapy of cancer><improved><individualized cancer care><individualized oncology><innovate><innovation><innovative><insight><intervention research><interventional research><interventional study><interventions research><malignancy><member><molecular imaging><molecule imaging><mortality><multidisciplinary><neoplasm immunology><neoplasm/cancer><new technology><novel technologies><oncologic imaging><oncology imaging><personalized oncology><physiological imaging><precision cancer care><precision cancer medicine><precision oncology><programs><screening><screening cancer patients><screenings><structural biology><tool><trend><tumor cell metastasis><tumor imaging><tumor immunology><tumorigenesis><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Yolanda Sanchez

UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, ALBUQUERQUE, NM

Exploratory lead · 44/100
Likely hiring
Active award
Team-scale grant
$60,000
FY 2025

Project Title

Early Career Cancer Clinical Investigator Award (ECIA)

Grant Number:

3P30CA118100-20S2

Activity Code:

P30

Mechanism:

Research Centers

Agency:

NIH

Start Date:

9/26/2005

End Date:

8/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT:   The overarching goal of the University of New Mexico Comprehensive Cancer Center (UNMCCC) Cancer Research Training and Education Coordination Core (CRTECC) is to prepare a diverse group of trainees to conduct cancer research in the context of laboratory, clinical, and community settings ...

Research Terms

<Advanced Cancer><Advanced Malignant Neoplasm><Advisory Committees><American Indian><Behavioral><Black><Black race><CCOP><CCSG><Cancer Biology><Cancer Burden><Cancer Center><Cancer Center Director><Cancer Center Support Grant><Cancer Control><Cancer Control Research><Cancer Control Science><Cancers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Catchment Area><Causality><Center for Cancer Research><Characteristics><Clinic><Clinical><Clinical Investigator Award><Clinical Treatment><Clinical Trials Network><Collaborations><Communities><Community Clinical Oncology Program><Community Health><Community Health Systems><Community Oncology><Community Outreach><Comprehensive Cancer Center><Data><Development Plans><Disparities><Disparity><Doctor of Philosophy><EXTMR><Education><Education and Training><Educational Activities><Educational aspects><Environment><Environment-Related Malignant Neoplasm><Environmental Cancer><Environmental Exposure><Environmental Malignant Neoplasm><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Etiology><Evaluation><Event><Extramural><Extramural Activities><Faculty><Fellowship><Fellowship Program><Fostering><Foundations><Funding><Genetic><Genomic medicine><Goals><Grant><Grant Review><HPV screening><Health><Health system><High School Student><Hispanic><Human Papilloma Virus screening><Incidence><Individual><Informatics><Infrastructure><Institution><Institutional support resources><Instruction><Interdisciplinary Research><Interdisciplinary Study><Intervention><Investigators><K-Awards><K-Series Research Career Programs><K08 Mechanism><K08 Program><Laboratories><Latino><Leadership><Logic><Malignant Neoplasms><Malignant Tumor><Mentors><Mentorship><Mexican><Minority><Mission><Modeling><Multidisciplinary Collaboration><Multidisciplinary Research><NCI Center for Cancer Research><National Cancer Burden><New Mexico><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Oncology><Oncology Cancer><Outcome Measure><Pattern><Persons><Ph.D.><PhD><Population><Population Sciences><Provider><Public Health><Publications><Registries><Research><Research Career Program><Research Institute><Research Personnel><Research Resources><Researchers><Resource Sharing><Resources><Rural><SEER Program><SEER-Surveillance, Epidemiology, and End Results><Science><Scientific Publication><Scientist><Secondary School Student><Secondary Student><Series><Source><Strategic Planning><Structure><Students><Surveillance, Epidemiology and End Results><Surveillance, Epidemiology, and End Results Program><Survey Instrument><Surveys><Task Forces><Technology><Therapeutic><Training><Training Programs><Training Support><Training and Education><Translating><Translational Research><Translational Science><Translations><Travel><Trust><Underrepresented Ethnic Minority><Underrepresented Minority><Universities><Visualization><Woman><advisory team><anti-cancer research><cancer care><cancer clinical trial><cancer disparity><cancer education><cancer health disparity><cancer prevention><cancer research><cancer research center director><cancer-related health disparity><care delivery><career><career development><causation><cellular oncology><clinical care><clinical intervention><clinical therapy><community engagement><community intervention><community level intervention><community setting><community-based health><community-based intervention><computer based prediction><data modeling><disease causation><disparity in cancer><education access><engagement with communities><environment related cancer><ethnic diversity><ethnic subgroup><ethnically diverse><ethnicity group><gender diversity><genome medicine><hack day><hackathon><hackfest><health equity><high schoolers><hispanic community><improved><inter-institutional><lectures><malignancy><measurable outcome><meeting><meetings><member><model of data><model the data><modeling of the data><molecular oncology><mortality><multi-ethnic><multiethnic><neoplasm/cancer><novel><oncology clinical trial><outcome measurement><population based><predictive modeling><programs><racial diversity><racially diverse><respiratory><role model><screening><screenings><skill acquisition><skill development><skills><social><socio-economic><socio-economically><socioeconomically><socioeconomics><translation><translation research><translational cancer research><translational investigation><trial regimen><trial treatment><tribal Nation><tribal governance><tribal government><tribal self-governance><tumor registry><under-representation of minorities><under-represented minority><underrepresentation of minorities>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

LINDA A DIMEGLIO

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 42/100
Large award
Active award
Career award
$3,723,874
FY 2025

Project Title

Diabetes-Docs: Physician-Scientist Career Development Program (DiabDocs)

Grant Number:

5K12DK133995-04

Activity Code:

K12

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/8/2022

End Date:

5/31/2027

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

The prime objective of our multi-center National K12 “Diabetes-Docs: Physician-Scientist Career Development Program” (DiabDocs) is to support the research career development of the next generation of physician-scientists in basic and clinical diabetes for academic careers with a specific focus on ty...

Research Terms

<21+ years old><Adult><Adult Human><American><Award><Basic Research><Basic Science><Brittle Diabetes Mellitus><Caliber><Clinical><Clinical Sciences><Diabetes Mellitus><Education><Educational aspects><Effectiveness><Endocrinology><Ensure><Funding><Geography><Goals><Grant><Health Services Evaluation><Health Services Research><IDDM><Institution><Insulin-Dependent Diabetes Mellitus><Investigation><Investigators><Juvenile-Onset Diabetes Mellitus><K12><K12 Award><K12 Mechanism><K12 Program><Ketosis-Prone Diabetes Mellitus><Leadership><Length><Letters><MD students><Medical Care Research><Medical Students><Medicine><Mentored Clinical Scientist Development Program><Mentors><Metabolism and Endocrinology><Pathway interactions><Physicians><Position><Positioning Attribute><Process><Program Development><Recruitment Activity><Research><Research Personnel><Research Resources><Research Support><Researchers><Resources><Scholars Program><Science><Scientist><Structure><Sudden-Onset Diabetes Mellitus><T1 DM><T1 diabetes><T1D><T1DM><Training><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Visit><active recruitment><adulthood><arm><bench bed side><bench bedside><bench to bed side><bench to bedside><bench to clinic><bench to clinical practice><career><career development><catalyst><cohesion><cohort><design><designing><diabetes><experience><insulin dependent diabetes><insulin dependent type 1><interest><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><medical school students><mentoring community><multidisciplinary><next generation><pathway><patient centered><patient oriented><programs><recruit><services research><skills><type I diabetes><type one diabetes>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

David Matthew Maahs

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 42/100
Large award
Active award
Career award
$3,723,874
FY 2025

Project Title

Diabetes-Docs: Physician-Scientist Career Development Program (DiabDocs)

Grant Number:

5K12DK133995-04

Activity Code:

K12

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/8/2022

End Date:

5/31/2027

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

The prime objective of our multi-center National K12 “Diabetes-Docs: Physician-Scientist Career Development Program” (DiabDocs) is to support the research career development of the next generation of physician-scientists in basic and clinical diabetes for academic careers with a specific focus on ty...

Research Terms

<21+ years old><Adult><Adult Human><American><Award><Basic Research><Basic Science><Brittle Diabetes Mellitus><Caliber><Clinical><Clinical Sciences><Diabetes Mellitus><Education><Educational aspects><Effectiveness><Endocrinology><Ensure><Funding><Geography><Goals><Grant><Health Services Evaluation><Health Services Research><IDDM><Institution><Insulin-Dependent Diabetes Mellitus><Investigation><Investigators><Juvenile-Onset Diabetes Mellitus><K12><K12 Award><K12 Mechanism><K12 Program><Ketosis-Prone Diabetes Mellitus><Leadership><Length><Letters><MD students><Medical Care Research><Medical Students><Medicine><Mentored Clinical Scientist Development Program><Mentors><Metabolism and Endocrinology><Pathway interactions><Physicians><Position><Positioning Attribute><Process><Program Development><Recruitment Activity><Research><Research Personnel><Research Resources><Research Support><Researchers><Resources><Scholars Program><Science><Scientist><Structure><Sudden-Onset Diabetes Mellitus><T1 DM><T1 diabetes><T1D><T1DM><Training><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Visit><active recruitment><adulthood><arm><bench bed side><bench bedside><bench to bed side><bench to bedside><bench to clinic><bench to clinical practice><career><career development><catalyst><cohesion><cohort><design><designing><diabetes><experience><insulin dependent diabetes><insulin dependent type 1><interest><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><medical school students><mentoring community><multidisciplinary><next generation><pathway><patient centered><patient oriented><programs><recruit><services research><skills><type I diabetes><type one diabetes>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Mariel Gailey Kozberg

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$230,071
FY 2026

Project Title

Causes and Consequences of Leptomeningeal Bleeding in Cerebral Amyloid Angiopathy

Grant Number:

5K08NS131530-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract: Cerebral amyloid angiopathy (CAA), a small vessel disease characterized by the deposition of amyloid-β in the walls of cortical and leptomeningeal blood vessels of the brain, is a leading cause of intracerebral hemorrhage (ICH) in the elderly. Patients with CAA present clin...

Research Terms

<Acute><Alzheimer beta-Protein><Alzheimer's Amyloid beta-Protein><Alzheimer's amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Model><Animal Models and Related Studies><Apoplexy><Area><Attention><Award><Aβ><Bleeding><Blood><Blood - brain barrier anatomy><Blood Reticuloendothelial System><Blood Vessels><Blood-Brain Barrier><Body Tissues><Brain><Brain Nervous System><Brain Vascular Accident><Cerebral Amyloid Angiopathy><Cerebral Brain Hemorrhage><Cerebral Hemorrhage><Cerebral Parenchymal Hemorrhage><Cerebral Stroke><Cerebral hemisphere hemorrhage><Cerebrospinal Fluid><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cerebrovascular system><Cerebrum Hemorrhage><Chronic><Clinical><Congophilic Angiopathy><Cortical vasculature><DNA mutation><Data><Deposit><Deposition><Detection><Development><Development Plans><Elderly><Encephalon><Environment><Evaluation><Event><Extravasation><Future><General Hospitals><Genetic Change><Genetic defect><Genetic mutation><Goals><Hemato-Encephalic Barrier><Hemorrhage><Hereditary><Human><Inflammation><Inflammation Mediators><Inflammatory><Inherited><Injury><International><Intracerebral Hemorrhage><Knowledge><Lead><Leakage><Leptomeninges><Lesion><Link><Lobar><MR Imaging><MR Tomography><MRI><MRIs><Macrophage><Magnetic Resonance Imaging><Massachusetts><Mediating><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mentors><Mentorship><Microscopic><Microvascular Dysfunction><Modeling><Modern Man><Mutation><Mφ><NMR Imaging><NMR Tomography><Neurology><Nuclear Magnetic Resonance Imaging><Pathology><Patients><Pb element><Penetration><Prevention><Process><Recurrence><Recurrent><Research><Research Resources><Resources><Risk><Risk Factors><Rodent Model><Rupture><Safety><Sampling><Scientist><Secondary to><Siderosis><Spillage><Sporadic Cerebral Amyloid Angiopathy><Stroke><Subarachnoid Hemorrhage><Subarachnoid Space><Time><Tissues><Training><Vascular Diseases><Vascular Disorder><Vascular remodeling><Work><Zeugmatography><a beta peptide><abeta><abeta deposition><advanced age><amyloid beta><amyloid beta deposition><amyloid β deposition><amyloid-b protein><aβ deposition><beta amyloid fibril><blood loss><blood product><blood vessel disorder><blood vessels in the brain><bloodbrain barrier><brain attack><brain blood vessels><brain tissue><brain vasculature><career><career development><cerebral blood vessel><cerebral spinal fluid><cerebral vascular accident><cerebral vasculature><cerebrovascular accident><cerebrovascular amyloidosis><cerebrovascular vessels><cerebrovasculature><clinical diagnosis><conference><convention><cortical blood vessels><cortical microvascular><cortical microvessels><cortical vascular><cortical vessels><deep learning algorithm><determine efficacy><developmental><effective therapy><effective treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experience><experiment><experimental research><experimental study><experiments><genome mutation><geriatric><heavy metal Pb><heavy metal lead><human tissue><imaging in vivo><improved><in vivo><in vivo imaging><in vivo optical imaging><inflammation marker><inflammatory marker><inflammatory mediator><injuries><injury to the vasculature><injury to tissue><interdisciplinary approach><knowledge base><medical college><medical schools><microvascular complications><microvascular disease><model of animal><mouse model><multi-modality><multidisciplinary approach><multimodality><multiphoton excitation microscopy><multiphoton microscopy><murine model><neural inflammation><neuroinflammation><neuroinflammatory><neuropathologic><neuropathological><neuropathology><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><optic imaging><optical imaging><school of medicine><senior citizen><small vessel disease><soluble amyloid precursor protein><spinal fluid><stroked><strokes><summit><symposia><symposium><therapeutic target><tissue injury><vascular><vascular amyloid><vascular dysfunction><vascular inflammation><vascular injury><vasculopathy>
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Neel Dave Pasricha

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$219,343
FY 2026

Project Title

Human Ocular Surface Electrophysiology

Grant Number:

5K08EY033859-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY This is a 5-year mentored K08 award to facilitate the transition of Dr. Neel Pasricha, an ophthalmologist with cornea subspecialty training, to an independent investigator in ocular surface eye translational research. A strong group of experienced mentors at UCSF, scientific advisors...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Animals><Apical><Autoregulation><Award><CFTR><CFTR Protein><Calcium><Caring><Carrier Proteins><Cauterization><Cauterize><Cautery><Cell Communication and Signaling><Cell Culture Techniques><Cell Line><Cell Signaling><CellLine><Cellular injury><Chloride Channels><Chloride Ion Channels><Clinical Research><Clinical Study><Clinical Trials><Cornea><Cystic Fibrosis><Cystic Fibrosis Transmembrane Conductance Regulator><Data><Drugs><Dry Eye Syndromes><Dry eye disease><Duct><Duct (organ) structure><ENaC><Educational workshop><Electrophysiology><Electrophysiology (science)><Epithelial Cells><Epithelium><Experimental Animal Model><Experimental Models><Eye><Eye diseases><Eyeball><FDA approved><Film><Fluids and Secretions><Goals><High Throughput Assay><Homeostasis><Human><Impairment><In vivo analysis><Inflammatory><Intracellular Communication and Signaling><Investigators><Ion Transport><Ions><K channel><Keratoconjunctivitis Sicca><Knowledge><Lacrimal deficiency><Learning><Liquid substance><Math Models><Measurement><Measures><Medication><Membrane><Mentors><Methods><Mice><Mice Mammals><Modeling><Modern Man><Mucoviscidosis><Murine><Mus><Neurophysiology / Electrophysiology><Ocular desiccation><Ophthalmologist><Ophthalmology><Osmolar Concentration><Osmolarity><Pathway interactions><Patients><Pharmaceutical Preparations><Pharmacodynamics><Phase 2 Clinical Trials><Phase II Clinical Trials><Phenol Red><Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis-, S,S-dioxide><Phenolsulfonphthalein><Physiological Homeostasis><Potassium Channel><Potassium Ion Channels><Prevalence><Research><Research Personnel><Researchers><Residencies><Rewards><Role><Scientific Advances and Accomplishments><Signal Transduction><Signal Transduction Systems><Signaling><Societies><Strains Cell Lines><Stratified Epithelium><Surrogate Markers><Symptoms><Testing><Therapeutic><Training><Translating><Translational Research><Translational Science><Transport Protein Gene><Transport Proteins><Transporter Protein><Triazines><Work><Workshop><absorption><adulthood><animal model development><biological signal transduction><burden of disease><burden of illness><career development><cell culture><cell cultures><cell damage><cell injury><cellular damage><conjunctiva><corneal><corneal epithelial><corneal epithelium><cost><cultured cell line><cystic fibrosis transmembrane regulator><damage to cells><disease burden><drug candidate><drug development><drug discovery><drug efficacy><drug/agent><dry eye><electrical potential><electrophysiological><epithelial Na+ channel><epithelial sodium channel><experience><eye disorder><eye dryness><fluid><high throughput screening><human data><human subject><in vivo><in vivo evaluation><in vivo testing><inhibitor><injury to cells><lacrimal><liquid><mathematic model><mathematical model><mathematical modeling><membrane structure><mouse model><murine model><new diagnostics><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation diagnostics><novel><novel diagnostics><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><ocular disease><ocular disorder><ocular dryness><ocular signs of dryness><ocular surface><ocular surface disease><ocular surface disorder><ocular surface dryness><ophthalmopathy><pathway><pharmacologic><phase II protocol><programs><scientific accomplishments><scientific advances><skills><small molecule><social role><surrogate bio-markers><surrogate biomarkers><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tear deficiency><tool development><translation research><translational investigation>
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Irina De la Huerta

VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$207,847
FY 2026

Project Title

Mechanisms of Photoreceptor Contribution to Retinal Inflammation in Diabetic Retinopathy

Grant Number:

5K08EY032620-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2021

End Date:

10/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Diabetic retinopathy (DR) is the principal cause of blindness among working-age adults in the United States. In individuals with diabetes mellitus, the duration and the severity of hyperglycemia correlate with the risk of developing retinopathy, and have long been considered...

Research Terms

<(TNF)-α><21+ years old><Academic Medical Centers><Acceleration><Address><Adult><Adult Human><Age><Animal Model><Animal Models and Related Studies><Assay><Automobile Driving><Award><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Biological Assay><Biostatistical Methods><Blindness><Blood Vessels><Business-Friendly Atmosphere><CRE Recombinase><Cachectin><Cell Body><Cell Nucleus><Cells><Cellular biology><Culturing, in vitro Vertebrate, Primary><D-Glucose><Data><Development><Dextrose><Diabetes Mellitus><Diabetic Retinopathy><Disease><Disorder><Doctor of Medicine><Doctor of Philosophy><Dysfunction><Enterobacteria phage P1 Cre recombinase><Exposure to><Functional disorder><Funding><General Transcription Factor Gene><General Transcription Factors><Genes><Glia><Glial Cells><Glucose><Goals><Hyperglycemia><IL-1 alpha><IL-1-a><IL-1A><IL-1alpha><IL-1α><IL1-Alpha><IL1-α><IL1A Protein><IL1F1><In Vitro><Incidence><Individual><Inflammation><Inflammation Mediators><Inflammatory><Inflammatory Response><Interleukin 1alpha><Interleukin-1 alpha><Intervention><Investigators><Isoforms><KO mice><Knock-out Mice><Knockout Mice><Kolliker's reticulum><M.D.><Macrophage-Derived TNF><Mediating><Mediator><Mentors><Mentorship><Metabolic><Mice><Mice Mammals><Monocyte-Derived TNF><Muller glia><Muller's cell><Murine><Mus><Müller cell><Müller glia><NF-AT><NF-AT proteins><NFAT proteins><NFAT-1><NFATC proteins><NIH><National Institutes of Health><Neural Retina><Neuroglia><Neuroglial Cells><Neurosciences><Non-neuronal cell><Nonneuronal cell><Nucleus><Null Mouse><Outer pigmented layer of retina><Pathogenesis><Pathologic Processes><Pathological Processes><Pathology><Pathway interactions><Permeability><Ph.D.><PhD><Photoreceptor Cell><Photoreceptors><Photosensitive Cell><Physicians><Physiopathology><Pigment cell layer of retina><Pigmented layer of retina><Preinterleukin 1 Alpha><Prevalence><Primary Cell Cultures><Principal Investigator><Process><Production><Protein Isoforms><Proteins><Research><Research Personnel><Researchers><Retina><Retina Proper><Retinal Blood Vessels><Retinal Diseases><Retinal Disorder><Retinal Photoreceptors><Retinal Pigment Epithelium><Retinal Vessels><Retinal pigment epithelial cells><Rhodopsin><Risk><Role><STZ><Scientist><Severities><Short interfering RNA><Small Interfering RNA><Specialist><Streptozocin><Streptozotocin><Structure of retinal pigment epithelium><Surgeon><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Techniques><Testing><Therapeutic><Training><Transcription Factor Proto-Oncogene><Transcription factor genes><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><United States><United States National Institutes of Health><Universities><University Medical Centers><Vascular Diseases><Vascular Disorder><Vascular Endothelial Cell><Visual Purple><Visual Receptor><Work><Zanosar><adulthood><ages><authority><bacteriophage P1 recombinase Cre><blood vessel disorder><business-friendly environment><cell biology><cell type><clinical training><collaborative atmosphere><collaborative environment><cytokine><cytoplasmic nuclear factor of activated T-cells><developmental><diabetes><diabetic patient><driving><experience><hyperglycemic><in vitro Assay><in vivo><inflammatory mediator><inhibitor><interactive atmosphere><interactive environment><interdisciplinary atmosphere><interdisciplinary environment><loss of function><medical college><medical schools><model of animal><monolayer><mouse model><murine model><nerve cement><nuclear factors of activated T-cells><pathophysiology><pathway><peer-group atmosphere><peer-group environment><prevent><preventing><programs><promoter><promotor><response><retina blood vessel structure><retina disease><retina disorder><retinal vascular network><retinal vascular structure><retinal vasculature><retinopathy><school of medicine><siRNA><skills><social role><transcription factor><transcription factor NF-AT><vascular><vascular dysfunction><vasculopathy><vision development><vision loss><visual development><visual loss><visual system development>
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Daniel Q Sun

UNIVERSITY OF CINCINNATI, CINCINNATI, OH

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$200,122
FY 2026

Project Title

Rational Design of Magnetic Nanoparticles for Cochlear Drug Delivery

Grant Number:

5K08DC020780-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2023

End Date:

12/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Abstract I am a neurotologist and assistant professor in the department of Otolaryngology-Head and Neck Surgery at the Johns Hopkins University School of Medicine. I am applying for a K08 mentored surgeon-scientist career development award (CDA) to obtain further training related to chemical enginee...

Research Terms

<Affect><Animal Model><Animal Models and Related Studies><Assay><BDNF><Behavior><Bioassay><Biodistribution><Biological><Biological Assay><Body Tissues><Brain-Derived Neurotrophic Factor><Cancer Treatment><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cavia><Chemical Engineering><Clinic><Clinical><Clinical Treatment><Cochlea><Cochlear Organ><Custom><DNA><DNA Therapy><Data><Deoxyribonucleic Acid><Development><Devices><Diffusion><Drug Delivery><Drug Delivery Systems><Drug Kinetics><Drugs><Ear><Engineering><Equilibrium><Ethics><Face><Fe oxide><Gene Transfer Clinical><General Anesthesia><Genetic Intervention><Goals><Growth Agents><Growth Factor><Growth Substances><Guinea Pigs><Guinea Pigs Mammals><Head and Neck Surgery><Hearing><Hearing Loss><Histologic><Histologically><Histology><Human><Hypoacuses><Hypoacusis><Image><Implant><In Vitro><Injections><Inner Ear Disorder><Internal Ear><K-Awards><K-Series Research Career Programs><Labyrinth><Lead><Liquid substance><Macrogols><Magnetic nanoparticles><Magnetism><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Mediating><Mediator><Medication><Membrane><Mentors><Modeling><Modern Man><Needles><Nucleic Acids><Operative Procedures><Operative Surgical Procedures><Otolaryngology><Particle Size><Patients><Pb element><Penetration><Performance><Perilymph><Pharmaceutical Preparations><Pharmaceutics><Pharmacokinetics><Pharmacy (field)><Polyethylene Glycols><Polyethylene Oxide><Polyethyleneoxide><Polymers><Polyoxyethylenes><Predisposition><Property><Proteins><Proteins Growth Factors><Research><Research Career Program><Residual><Residual state><Risk><Scala Tympani><Scala Tympanus><Science><Scientist><Sensorineural Deafness><Sensorineural Hearing Loss><Sensory Hearing Loss><Severities><Study models><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Susceptibility><Techniques><Technology><Temporal Bone><Temporal bone structure><Therapeutic><Tissues><Training><Universities><Viral Vector><anti-cancer therapy><balance><balance function><biocompatibility><biologic><biomaterial compatibility><cancer therapy><cancer-directed therapy><career><chemical property><clinical intervention><clinical therapy><clinical translation><clinically translatable><cochlear development><cochlear window><colcothar><customs><delivery vector><delivery vehicle><developmental><diffused><diffuses><diffusing><diffusions><drug/agent><dysfunctional hearing><ethical><experience><faces><facial><fenestra cochleae><ferric oxide><fluid><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><guinea pig model><hearing challenged><hearing defect><hearing deficient><hearing deficit><hearing difficulty><hearing dysfunction><hearing impairment><hearing loss therapy><hearing loss treatment><heavy metal Pb><heavy metal lead><imaging><improved><in vivo><inner ear><inner ear diseases><interest><iron oxide><liquid><macromolecule><magnetic><magnetic field><medical college><medical schools><membrane structure><middle ear><minimally invasive><model of animal><molecular size><nano particle><nano-sized particle><nanoparticle><nanosized particle><neuronal growth><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><otorhinolaryngology><particle><pharmaceutic><pharmacokinetic model><physical property><polymer><polymeric><pre-clinical><preclinical><professor><rational design><red iron oxide><round window><school of medicine><sensorineural hearing impairment><skill acquisition><skill development><small molecule><superparamagnetic><superparamagnetism><surgery><treatment for hearing loss><trial regimen><trial treatment><validation studies>
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Alena Janda Markmann

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$195,235
FY 2026

Project Title

Defining Molecular Epitopes of Protective Antibodies to Flaviviruses

Grant Number:

5K08AI168569-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/4/2022

End Date:

1/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract: The objective of this K08 Mentored Clinical Scientist Career Award Application is to provide Dr. Alena Markmann with a strong foundation in human immunology and the latest methods for studying human immune cells before launching her independent research career on the human ...

Research Terms

<0-11 years old><21+ years old><7S Gamma Globulin><Ab response><Ab-mediated immunity><Ab-mediated protection><Acute><Adult><Adult Human><Affect><Antibodies><Antibody Formation><Antibody Production><Antibody Response><Antibody immunity><Antibody protection><Antibody-mediated protection><Antigenic Determinants><Antigens><Applications Grants><Appointment><Area><Assay><Award><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Binding><Binding Determinants><Binding Sites><Bioassay><Biological Assay><Blood Plasma><Blood Plasma Cell><Blood Serum><Bone Marrow><Bone Marrow Reticuloendothelial System><Breakbone Fever Virus><CDR3-region><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Cellular Assay><Child><Child Youth><Children (0-21)><Clinical><Clinical Treatment Moab><Clone Cells><Combining Site><Complementarity Determining Region III><Cross Reactions><Culicidae><DENV><DENV infection><Dengue><Dengue Hemorrhagic Fever><Dengue Infection><Dengue Virus><Dengue fever virus><Dengue virus infection><Development><Disease><Disorder><E protein><Epidemiology><Epitopes><Exposure to><Fever><Flavivirus><Flavivirus Infections><Foundations><Glycans><Grant Proposals><Group B Arbovirus><Hemorrhagic Shock><Human><Ig Somatic Hypermutation><IgG><Immune><Immune response><Immunes><Immunity><Immunoglobulin G><Immunoglobulin Somatic Hypermutation><Immunology><Individual><Infection><Instruction><Investigation><Ions><Japanese B Encephalitis Virus><Japanese encephalitis virus><Joints><Knowledge><Latin America><Life><Manuscripts><Maps><Marrow><Medicine><Memory B Cell><Memory B-Lymphocyte><Mentors><Metabolic Glycosylation><Methods><Microbiology><Modern Man><Molecular><Molecular Interaction><Monoclonal Antibodies><Morbidity><Mosquitoes><NIH><National Institutes of Health><North Carolina><Orthoflavivirus><Pathogenicity><Peptide Domain><Peptides><Plasma><Plasma Cells><Plasma Serum><Plasmacytes><Polysaccharides><Population><Protein Domains><Proteins><Proteomics><Publications><Pyrexia><RNA Viruses><Reactive Site><Recombinants><Research><Resolution><Reticuloendothelial System, Serum, Plasma><Role><Scientific Publication><Scientist><Serology><Serotyping><Serum><Site><Structure><Syndrome><Technology><Tertiary Protein Structure><Therapeutic><Time><Training><Transmission><United States National Institutes of Health><Universities><Vaccine Design><Viral><Viral Diseases><Viral Hemorrhagic Fevers><Virus><Virus Diseases><Virus Replication><West Nile><Work><Writing><Yellow Fever><ZIKA><ZIKV><ZIKV infected><ZIKV infection><ZIKV positive><ZIKV+><Zika Virus><Zika virus infection><adaptive immune response><adaptive immunity><adulthood><antibody biosynthesis><antibody-mediated immunity><career><career development><cell assay><cell sorting><complementarity-determining region 3><congenital zika syndrome><congenital zika virus syndrome><congenital zikv syndrome><convalescent plasma><cross reactivity><dengue viral infection><design><design and construct><design and construction><designing><developmental><dimer><epidemic virus><epidemiologic><epidemiological><experience><experiment><experimental research><experimental study><experiments><febrile><febris><glycosylation><hemorrhagic fever><high resolution imaging><host response><immune system response><immunogen><immunoglobulin biosynthesis><immunoresponse><improved><infected with ZIKV><infected with zika><kids><mAbs><medical college><medical schools><monoclonal Abs><neutralizing antibody><neutralizing mAb><neutralizing monoclonal antibodies><new technology><novel><novel technologies><plasmocyte><professor><recombinant virus><resolutions><response><school of medicine><screening><screenings><secondary infection><skills><social role><somatic hypermutation><tenure process><tenure track><third complementarity-determining region><tick mediated transmission><tick transmission><tick transmitted><tool><transmission process><vector mosquito><vector-borne><vectorborne><viral infection><viral multiplication><viral replication><virus development><virus infection><virus multiplication><virus-induced disease><youngster><zika infected><zika infection><zika viral infection><zikav>
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Ryan William Nelson

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$194,935
FY 2026

Project Title

Lung resident Treg suppression of Th2 resident memory T cells in allergicasthma

Grant Number:

5K08AI171176-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/4/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Defining how FoxP3+ regulatory T cells (Tregs) limit amnestic responses to common allergens has the potential to provide new and effective therapies for asthma and other atopic diseases. Recent work has demonstrated that T helper type 2 (Th2) tissue-resident memory T cells (Trm) pers...

Research Terms

<Adoptive Transfer><Advisory Committees><Affect><Airway Hyper-responsiveness><Allergens><Allergic><Allergic Disease><Allergic asthma><Allergic inflammation><Asthma><Autoregulation><Award><BONZO><Bioinformatics><Biological Response Modifiers><Biomodulators><Blood Eosinophil><Body Tissues><Boston><Bronchial Asthma><CCL1><CCL1 gene><CCL8><CCL8 gene><CCR8><CCR8 gene><CKR-L1><CKRL1><CMKBR8><CMKBRL2><CRISPR><CRISPR approach><CRISPR based approach><CRISPR editing screen><CRISPR method><CRISPR methodology><CRISPR screen><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based screen><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 screen><CRISPR/Cas9 technology><CXCR6><CXCR6 gene><CY6><Candidate Disease Gene><Candidate Gene><Cas nuclease technology><Cell Body><Cell Growth and Maintenance><Cell Isolation><Cell Maintenance><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Cellular biology><Chemokine Receptor Gene><Chemotactic Cytokines><Children's Hospital><Chronic><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Data><Development Plans><Disease><Disorder><Eosinophilic Granulocyte><Eosinophilic Leukocyte><Exposure to><Expression Signature><Extrinsic asthma><FOXP3><FOXP3 gene><Forkhead Box P3><Funding><GPR-CY6><Gene Expression Profile><Gene Transcription><General Hospitals><Genes><Genetic Transcription><Goals><HC14><Homeostasis><Homologous Chemotactic Cytokines><House Dust Mites><Housedust Mites><I-309><IL-13><IL13><Immune Mediators><Immune Mediators/Modulators><Immunology><Immunomodulation><Inflammation><Inflammatory><Inhalation><Inhaling><Intercrines><Interleukin-13><Investigators><JM2><Kinetics><Knowledge><Ligands><Lung><Lung Parenchyma><Lung Respiratory System><Lung Tissue><MCP-2><MCP2><Maintenance><Maps><Marrow Eosinophil><Massachusetts><Mediating><Memory><Mentors><Mentorship><Metaplasia><Metaplastic Change><Mice><Mice Mammals><Microscopy><Modeling><Mucous body substance><Mucus><Murine><Mus><NIH><National Institutes of Health><P500><Parabiosis><Pediatric Hospitals><Peptides><Phase><Phenotype><Physiological Homeostasis><Position><Positioning Attribute><Pyroglyphidae><RNA Expression><Regulatory T-Lymphocyte><Reporter><Research><Research Methodology><Research Methods><Research Personnel><Researchers><Residencies><Resolution><Role><SCURFIN><SCYA1><SCYA10><SCYA8><SIS cytokines><SISe><STRL33><Structure of parenchyma of lung><System><Systems Biology><T cell differentiation><T-Cells><T-Lymphocyte><TCA3><TER1><TYMSTR><Task Forces><Testing><Th-2 Cell><Th2 Cells><Therapeutic><Tissues><Training><Transcription><Transgenic Organisms><Translational Research><Translational Science><Treg><Type 2 Helper Cell><United States National Institutes of Health><Work><advisory team><aeroallergens><airborn allergen><airborne allergen><airway hyper-reactivity><airway hyperactivity><airway hyperreactivity><airway hyperresponsiveness><airway hypersensitivity><asthma model><atopic asthma><career development><cell biology><cell sorting><chemoattractant cytokine><chemokine><chemokine receptor><clustered regularly interspaced short palindromic repeats screen><disease model><disorder model><effective therapy><effective treatment><eosinophil><extrinsic allergic asthma><gene expression pattern><gene expression signature><genome editing><genomic editing><human disease><immune modulation><immune regulation><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><in vivo><mouse model><mucosal site><mucous><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><programs><recruit><regulatory T-cells><research and methods><resident memory T cell><resolutions><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><thymus derived lymphocyte><tissue resident memory T cell><transcriptional profile><transcriptional signature><transcriptomics><transgenic><translation research><translational investigation>
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John J. Erickson

CINCINNATI CHILDRENS HOSP MED CTR, CINCINNATI, OH

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$193,212
FY 2026

Project Title

Maternal B cells enforce fetal tolerance

Grant Number:

5K08AI180350-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY TITLE: Maternal B cells enforce fetal tolerance GOALS/OBJECTIVES: The overall goal of this five-year proposal for a Mentored Clinical Scientist Research Career Development Award (K08) is for me to develop into a productive, independent academic investigator in the field of reproducti...

Research Terms

<0-11 years old><0-4 weeks old><Acceleration><Adoptive Transfer><Affect><Allogenic><American><Antibodies><Antigens><Area><Award><B blood cells><B cell><B cell depletion therapy><B cell differentiation><B cell directed therapy><B cell receptor><B cell targeted therapy><B cell therapies><B cell therapy><B cells><B lymphocyte differentiation><B-Cell Activation><B-Cell Antigen CD22><B-Cell Antigen Receptor><B-Cell Subsets><B-Cells><B-Lymphocyte Subsets><B-Lymphocytes><B-cell><B3 antigen><Binding><Blocking Antibodies><Body Tissues><CD22><CD22 antigen><CD22 gene><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CSIF><CSIF-10><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cas nuclease technology><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Signaling><Cell-to-Cell Interaction><Cells><Cells Placenta-Tissue><Cellular Immunology><Cellular biology><Child><Child Youth><Childhood><Children (0-21)><Children's Hospital><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complex><Cytokine Synthesis Inhibitory Factor><Data><Developing fetus><Disparate><Doctor's Assistants><EPH Gestosis><Effector Cell><Equilibrium><FOXP3><FOXP3 gene><Faculty><Fellowship><Fetal Death><Fetal Development><Fetal Tissues><Fetus><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Forkhead Box P3><Functional impairment><Genes><Genetic><Genetic Diversity><Genetic Variation><Gestation><Glycans><Glycobiology><Glycoproteins><Goals><Hand><Host Defense><IL-10><IL-10 receptor><IL10><IL10A><Immune><Immune Cell Suppression><Immune Tolerance><Immune system><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Tolerance><Immunological><Immunologically><Immunologics><Immunology><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Impairment><Infant><Infection><Interleukin 10 Precursor><Interleukin-10><International><Intracellular Communication and Signaling><Investigators><JM2><K-Awards><K-Series Research Career Programs><Knowledge><Laboratories><Ligands><Link><Lymphatic cell><Lymphocyte><Lymphocytic><Maternal Health><Measures><Mediating><Mediator><Mentors><Mentorship><Metabolic Glycosylation><Mice><Mice Mammals><Microchimerism><Modification><Molecular Interaction><Mothers><Murine><Mus><N-Acetylneuraminic Acids><Neonatal><Neonatal Mortality><Neonatology><Newborn Infant><Newborns><Normal Placentoma><Ovalbumin><Pathway interactions><Pediatric Hospitals><Pediatrics><Perinatal><Peripartum><Physician Assistants><Physicians><Physicians' Extenders><Placenta><Placenta Embryonic Tissue><Placentome><Polysaccharides><Position><Positioning Attribute><Pre-Eclampsia><Predisposition><Preeclampsia><Pregnancy><Pregnancy Complications><Pregnancy Outcome><Pregnancy Toxemias><Pregnant Women><Premature Birth><Prematurely delivering><Preterm Birth><Productivity><Proliferating><Property><Proteinuria-Edema-Hypertension Gestosis><Receptor Protein><Receptor Signaling><Regulation><Regulatory T-Lymphocyte><Reporter><Reproduction Immunology><Reproductive Immunology><Research><Research Assistant><Research Career Program><Research Personnel><Research Resources><Researchers><Residencies><Resources><Role><SCURFIN><SIGLEC2><Scientist><Sialic Acid-Binding Immunoglobulin-Like Lectin 2><Sialic Acids><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Susceptibility><Symbiosis><T-Cells><T-Lymphocyte><T8 Cells><T8 Lymphocytes><Teff cell><Tissues><Training><Transgenic Mice><Transgenic Organisms><Treg><Universities><Work><activated B cells><balance><balance function><biological signal transduction><career><career development><cell biology><cell type><changes associated with pregnancy><commensalism><complications during pregnancy><conference><convention><death among neonates><death among newborns><death in neonates><death in newborn><effector T cell><embryo/fetus antigen><expectant mother><expectant women><expecting mother><expecting women><experience><experiment><experimental research><experimental study><experiments><fetal><fetal antigen><fetal loss><fetus death><fetus loss><fetus tissue><flow cytophotometry><gene editing method><gene editing methodology><gene editing strategy><gene editing techniques><gene manipulation><gene-editing approach><genetic manipulation><genetically manipulate><genetically perturb><glycosylation><hands><healthy pregnancy><immune suppression><immune suppressive activity><immune suppressive function><immune system tolerance><immune unresponsiveness><immunogen><immunological paralysis><immunosuppressive activity><immunosuppressive function><immunosuppressive response><improved><improved outcome><individuals who are pregnant><innovate><innovation><innovative><interleukin-10 receptor><kids><loss of function><lymph cell><lymph organ><lymphatic organ><lymphoid organ><male><maternal immune system><maternal morbidity><mortality><mortality among neonates><mortality among newborns><mortality in neonates><mortality in newborns><mother immune system><mouse model><murine model><neonatal death><neonatal demise><neonatal immunity><neonatal morbidity><neonatal outcome><neonatal sepsis><neonate><newborn child><newborn children><newborn death><newborn morbidity><newborn mortality><novel><offspring><pathway><pediatric><people who are pregnant><perinatal medicine><pre-eclamptic><pregnancy associated alterations><pregnancy associated changes><pregnancy immunology><pregnancy induced alterations><pregnancy induced changes><pregnancy related alterations><pregnancy toxemia/hypertension><pregnancy-related complications><pregnant females><pregnant mothers><pregnant people><pregnant populations><premature childbirth><premature delivery><preterm delivery><prevent><preventing><professor><programs><receptor><receptor binding><receptor bound><receptor expression><regulatory T-cells><reproductive><response><sialylation><social role><stillbirth><stillborn><summit><symposia><symposium><those who are pregnant><thymus derived lymphocyte><tool><transgenic><translational goal><translational mission><women who are pregnant><youngster><♂>
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Melissa Mazor

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$190,755
FY 2026

Project Title

The Development and Evaluation of a Community-Based, Early Palliative Care Intervention for Black Women with Metastatic Breast Cancer

Grant Number:

5K08CA267309-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/20/2021

End Date:

11/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Research: Early palliative care (PC) for patients with advanced cancer is an understudied area of health outcomes research. Patients with metastatic breast cancer (MBC) disproportionality suffer from the psychological and physical impacts of living with this serious condition. The purpose of this st...

Research Terms

<Address><Advanced Cancer><Advanced Malignant Neoplasm><Area><Award><Biometrics><Biometry><Biostatistics><Black><Black race><Breast Cancer><Cancer Patient><Cancers><Caring><Chronic Care><Clinic><Clinical><Clinical Trials><Clinical Trials Design><Communities><Complex><Data><Development><Diagnosis><Discipline of Nursing><Disparities><Disparity><Dissemination and Implementation><Distress><Environment><Evaluation><Evidence based intervention><Family><Feedback><Focus Groups><Foundations><Funding><Geriatrics><Goals><Grant><Health><Health Care Systems><Health Disparities Research><Health Services><Health disparities related research><Improve Access><Individual><Institution><Internal Medicine><Intervention><Investigators><Knowledge><Leadership><Malignant Breast Neoplasm><Malignant Neoplasms><Malignant Tumor><Medicine><Mentors><Metastatic breast cancer><Methods><Modeling><Morbidity><NCI-Designated Cancer Center><NIH><National Institutes of Health><New York City><Nurses><Nursing><Nursing Field><Nursing Profession><Oncologist><Oncology><Oncology Cancer><Outcomes Research><Palliative Care><Palliative Medicine><Palliative Therapy><Palliative Treatment><Patient Care><Patient Care Delivery><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Persons><Population><Preparation><Randomized, Controlled Trials><Recommendation><Research><Research Activity><Research Infrastructure><Research Personnel><Research Support><Researchers><Scholarship><Screening for cancer><Self Management><Solid><Symptom Burden><Testing><Time><Training><Training Activity><United States National Institutes of Health><Writing><attentional control><black female><black women><cancer disparity><cancer health disparity><cancer-related health disparity><care delivery><care for patients><care of patients><care outcomes><career development><caring for patients><cognitive interview><comfort care><design><designing><develop therapy><developmental><differences in health><disparity in cancer><disparity in health><early cancer detection><end of life><end-of-life><evidence base><experience><geriatric medicine><health care outcomes><health difference><health disparities science><health disparity><improved><innovate><innovation><innovative><intervention arm><intervention delivery><intervention development><malignancy><malignant breast tumor><manage symptom><medical college><medical schools><medical vulnerability><metastatic breast tumor><metastatic mammary cancer><metastatic mammary tumor><mortality><multidisciplinary><neoplasm/cancer><nurse><palliative intervention><participant engagement><patient engagement><patient oriented outcomes><patient population><physical symptom><preparations><primary outcome><programs><psychologic><psychological><psychological symptom><randomized control trial><school of medicine><screening cancer patients><skills><social><social determinants><sociodeterminant><symptom management><therapy development><training module><treatment arm><treatment development>
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Matthew Steven Krantz

VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$186,332
FY 2026

Project Title

A Translational Bioinformatics Approach for Phenotyping and Genetic Risk of Severe Cutaneous Adverse Drug Reactions

Grant Number:

5K08AI185260-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/15/2025

End Date:

12/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Drug reaction with eosinophilia and systemic symptoms (DRESS) is a life-threatening severe cutaneous adverse drug reaction (SCAR). Vancomycin is the first-line treatment for multidrug-resistant gram-positive bacteria and is the most common drug associated with DRESS in the United Sta...

Research Terms

<Advisory Committees><Alleles><Allelomorphs><Allergic><Allergic Disease><Allergy><Aminopeptidase><Autoimmune Diseases><Bioinformatics><Cancers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Class I Antigens><Class I Major Histocompatibility Antigens><Clinical><Communicable Diseases><Complex Class 1><Control Groups><Cutaneous><DNA><Data><Deoxyribonucleic Acid><Diagnosis><Disease><Disorder><Drug Allergy><Drug Hypersensitivity><Drug Tolerance><Drugs><Early Diagnosis><Electronic Health Record><Electronic Medical Records and Genomics Network><Endoplasmic Reticulum><Environment><Eosinophilia><Epistasis><Epistatic Deviation><Ergastoplasm><Foundations><Future><GWA study><GWAS><Gene variant><Genetic><Genetic Diversity><Genetic Epistasis><Genetic Risk><Genetic Variation><Genetic predisposing factor><Genotype><Goals><Gram-Positive Bacteria><HL-A Antigens><HLA Antigens><HLA testing><HLA typing><Histocompatibility Antigens Class I><Hospital Admission><Hospitalization><Human Leukocyte Antigens><Hypersensitivity><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune Globulins><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immunes><Immunochemical Immunologic><Immunogenomics><Immunoglobulins><Immunologic><Immunologic Diseases><Immunological><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Immunologically><Immunologics><Immunology><Individual><Infectious Diseases><Infectious Disorder><Interaction Deviation><Interdisciplinary Research><Interdisciplinary Study><K Cells><K-Awards><K-Series Research Career Programs><Killer Cells><Knowledge><Laboratories><Lead><Learning><Leukocyte Antigens><Life><Link><MHC Class I Molecule><MHC Class I Protein><MHC class I antigen><Machine Learning><Major Histocompatibility Complex Class 1><Malignant Neoplasms><Malignant Tumor><Mediating><Medication><Mentors><Mentorship><Metabolic><Methods><Modeling><Morbidity><Multi-Drug Resistance><Multidisciplinary Collaboration><Multidisciplinary Research><Multidrug Resistance><Multiple Drug Resistance><Multiple Drug Resistant><NIH><National Institutes of Health><Pathogenesis><Pathway interactions><Patients><Pb element><Pharmaceutical Preparations><Phenotype><Population><Population Heterogeneity><Precision care><Predicting Risk><Predictive Value><Predisposition><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Prospective cohort><Proteomics><R-Series Research Projects><R01 Mechanism><R01 Program><Reaction><Receptor Protein><Reproducibility><Research><Research Career Program><Research Grants><Research Project Grants><Research Projects><Resistance><Resistance to Multi-drug><Resistance to Multidrug><Resistance to Multiple Drug><Resistant to Multiple Drug><Resistant to multi-drug><Resistant to multidrug><Risk><Risk Factors><Secondary to><Severities><Susceptibility><Symptoms><Syndrome><Task Forces><Testing><Training><Translating><United States><United States National Institutes of Health><Vancomycin><Variant><Variation><Ziagen><abacavir><adverse drug reaction><advisory team><allelic variant><autoimmune condition><autoimmune disorder><autoimmunity disease><biobank><biomarker identification><biorepository><career><co-morbid><co-morbidity><cohort><comorbidity><computer based prediction><design><designing><diverse populations><drug/agent><eMERGE Consortium><eMERGE Network><early detection><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><entire genome><epistatic interaction><epistatic relationship><forecasting risk><full genome><gene x gene interaction><genetic epistases><genetic risk factor><genetic variant><genome sequencing><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic variant><heavy metal Pb><heavy metal lead><heterogeneous population><human leukocyte antigen testing><human leukocyte antigen typing><identification of biomarkers><identification of new biomarkers><improved><individualized care><individualized patient care><inherited factor><innovate><innovation><innovative><insight><machine based learning><malignancy><marker identification><multi-drug resistant><multi-ethnic><multidrug resistant><multiethnic><multiomics><multiple omics><neoplasm/cancer><panomics><pathway><personalized care><personalized patient care><phenome><phenotyping algorithm><population diversity><precision medicine><precision-based medicine><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive modeling><predictive risk><predicts risk><prevent><preventing><prospective><receptor><resistant><risk prediction><risk predictions><screening><screenings><skills><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><trait><transcriptomics><whole genome><whole genome association analysis><whole genome association study>
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Yin Ren

OHIO STATE UNIVERSITY, Columbus, OH

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$184,001
FY 2026

Project Title

Engineering protease biomarkers to guide surgical therapy for vestibular schwannoma and Neurofibromatosis Type 2

Grant Number:

5K08DC020761-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT Neurofibromatosis type 2 (NF2) is a profoundly devastating tumor predisposing syndrome characterized by multiple nervous system tumors that cause substantial debility for patients. The hallmark of NF2 is bilateral vestibular schwannomas (VS) which cause hearing loss, imbalance, brainstem c...

Research Terms

<72-kDa Gelatinase><72-kDa Type IV Collagenase><72kD type IV Collagenase><92-kDa Gelatinase><92-kDa Type IV Collagenase><Abscission><Acoustic Neurilemmoma><Acoustic Neurilemoma><Acoustic Neurinoma><Acoustic Neuroma><Acoustic Schwannoma><Acquired brain injury><Adhesions><Advisory Committees><Ancient Neurilemmoma><Ancient Schwannoma><Animal Model><Animal Models and Related Studies><Anti-Oncogenes><Antioncogenes><Architecture><Area><Basicranium><Basis cranii><Behavior><Benign><Biological><Biological Markers><Biology><Blood Serum><Body Tissues><Brain><Brain Injuries><Brain Neoplasia><Brain Neoplasms><Brain Nervous System><Brain Stem><Brain Tumors><Brainstem><CNS Nervous System><Cancer Suppressor Genes><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Body><Cell Line><Cell Locomotion><Cell Migration><Cell Movement><Cell model><Cell-Extracellular Matrix><CellLine><Cells><Cellular Migration><Cellular Motility><Cellular model><Central Nervous System><Central Neurofibromatosis><Cessation of life><Classification><Cochlea><Cochlear Organ><Communication><Convection><Cranial Base><Cranial Nerves><Craniotomy><Cues><Cystic Neoplasm><Cystic Tumor><Data><Death><Debility><Degenerated Neurilemmoma><Degenerated Schwannoma><Disabling><Disease><Disorder><Dissection><Drug Therapy><Drugs><ECM><Educational workshop><Emerogenes><Encephalon><Engineering><Engineering / Architecture><Esteroproteases><Excision><Extirpation><Extracellular Matrix><FDA approved><FRET><Face><Facial Injuries><Facial Nerve Paralysis><Facial Palsy><Facial paralysis><Fluorescence Resonance Energy Transfer><Foundations><Future><Förster Resonance Energy Transfer><Gelatinase A><Gelatinase B><Gelatinase Neutrophil><Generalized Growth><Genomics><Goals><Growth><Hearing><Hearing Loss><Heterograft><Heterologous Transplantation><High Throughput Assay><Home><Human><Hypoacuses><Hypoacusis><Impairment><Incidence><Intracranial Central Nervous System Neoplasms><Intracranial Central Nervous System Tumors><Intracranial Neoplasms><Intracranial Tumor><K-Awards><K-Series Research Career Programs><Label><Libraries><MMP-2><MMP-9><MMP-9 Protein><MMP14><MMP14 gene><MMPs><MT1-MMP><Macrophage Gelatinase><Matrix Metalloproteinase-14><Matrix Metalloproteinase-2><Matrix Metalloproteinase-9><Matrix Metalloproteinases><Medication><Membrane-Type Matrix Metalloproteinase 1><Membrane-Type Matrix Metalloproteinase 14><Mentors><Mentorship><Metallopeptidases><Metalloproteases><Metalloproteinases><Methods><Mice><Mice Mammals><Modern Man><Morbidity><Murine><Mus><Nanotechnology><Nature><Nerve><Nervous System Neoplasms><Neuraxis><Neurilemmoma><Neurilemoma><Neurinoma><Neurofibromatosis 2><Neurofibromatosis II><Neurofibromatosis Type 2s><Neurologic><Neurological><Ohio><Onco-Suppressor Genes><Oncogenes-Tumor Suppressors><Operative Procedures><Operative Surgical Procedures><Outcome><Palsy><Paralysed><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pattern><Penetration><Peptidases><Peptide Hydrolases><Peptides><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Physicians><Play><Plegia><Principal Investigator><Prognostic Marker><Protease Gene><Proteases><Proteinases><Proteolytic Enzymes><RNA Seq><RNA sequencing><RNAseq><Recessive Oncogenes><Removal><Research><Research Career Program><Risk><Role><Schwannoma><Scientist><Sensitivity and Specificity><Serum><Specificity><Strains Cell Lines><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><Survival Rate><Syndrome><Systematics><Task Forces><Testing><Therapeutic><Tissue Growth><Tissues><Training><Translating><Translational Research><Translational Science><Tumor Cell><Tumor Suppressing Genes><Tumor Suppressor Genes><Tumor Tissue><Type 2 Neurofibromatosis><Type II Neurofibromatosis><Type V Collagenase><Universities><Vestibular Neurilemmoma><Visual><Visualization><Work><Workshop><Xenograft><Xenograft Model><Xenograft procedure><Xenotransplantation><acoustic neurofibromatosis><advisory team><angiogenesis><bilateral vestibular Schwannoma><bio-markers><biologic><biologic marker><biomarker><biomarker identification><brain damage><brain-injured><career><cell motility><cultured cell line><deafness><design><designing><disease classification><disorder classification><drug intervention><drug treatment><drug/agent><dysfunctional hearing><face injury><faces><facial><gene function><genomic data><genomic dataset><hearing challenged><hearing defect><hearing deficient><hearing deficit><hearing difficulty><hearing dysfunction><hearing impairment><high throughput screening><homes><identification of biomarkers><identification of new biomarkers><improved><improved outcome><in vivo><injury to the face><innovate><innovation><innovative><marker identification><model of animal><molecular biomarker><molecular marker><mouse model><multidisciplinary><murine model><nano particle><nano particle delivery><nano tech><nano technology><nano-sized particle><nano-technological><nanomaterials><nanoparticle><nanoparticle delivered><nanoparticle delivery><nanosized particle><nanotech><nanotechnological><neoplastic cell><nervous system tumor><new diagnostics><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation diagnostics><next generation therapeutics><nosology><novel diagnostics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><oncosuppressor gene><ontogeny><overexpress><overexpression><paralysis><paralytic><patient oriented outcomes><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><point of care><preservation><prognostic biomarker><prognostic indicator><resection><safe patient><skull base><skull incision><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><surgery><surgery outcome><surgical outcome><systems research><tool><transcriptome profiling><transcriptome sequencing><transcriptomic profiling><transcriptomic sequencing><translation research><translational investigation><tumor><tumor growth><tumors in the brain><vestibular Schwannoma><xeno-transplant><xeno-transplantation><xenograft transplant model><xenotransplant model>
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Benjamin Henry Gern

SEATTLE CHILDREN'S HOSPITAL, SEATTLE, WA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$183,968
FY 2026

Project Title

Dissecting the molecular regulation of T cell localization and function within the Mycobacterium tuberculosis granuloma

Grant Number:

5K08AI166072-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/13/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Mycobacterium tuberculosis (Mtb) infection is a major global health problem. Despite widespread immunization with Bacillus Calmette–Guérin and availability of antibiotic therapy, there are 10 million new cases and 1.4 million deaths annually, underscoring the need for improv...

Research Terms

<Ablation><Address><Affect><Antibiotic Agents><Antibiotic Drugs><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Antigens><Assay><Autopsy><Award><BCG Live><BLR1><BLR1 gene><Bacille Calmette-Guérin><Bacillus Calmette Guérin><Bioassay><Biological Assay><Body Tissues><Bone-Derived Transforming Growth Factor><CC chemokine receptor 7><CC chemokine receptor CCR7><CCR6><CCR6 gene><CCR7 protein><CD183><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CKR-L2><CKRL3><CMKAR3><CXCR-5><CXCR3><CXCR3 gene><CXCR5><Career Mobility><Cell Body><Cell Communication and Signaling><Cell Mediated Immunology><Cell Signaling><Cell-Mediated Immunity><Cells><Cellular Immunity><Cessation of life><Chemokine (C-X-C Motif) Receptor 3><Chemokine Receptor Gene><Chemokine Receptor-Like 3><Clinical><Death><Development><Development Plans><Diffuse><Disease Outcome><Dose><Ectopic lymphoid organ><Ectopic lymphoid structure><Exhibits><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Future><G Protein-Coupled Receptor 29><G Protein-Coupled Receptor 9><GPR29><GPR9><GPRCY4><Gene Transcription><Genetic><Genetic Transcription><Goals><Granuloma><Granulomatous Lesion><Homing><Human><IP10><IP10 Receptor><IP10-Mig receptor><IP10-R><Image><Imaging Device><Imaging Instrument><Imaging Tool><Immune><Immune response><Immunes><Immunity><Immunization><Immunology><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><In Situ><Individual><Infection><Infiltration><Intracellular Communication and Signaling><Investigation><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Knowledge><Laboratories><Learning><Lung><Lung Granuloma><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Lung infections><Lymphatic cell><Lymphocyte><Lymphocytic><M tb><M tuberculosis><M tuberculosis infection><M. tb><M. tb infection><M. tuberculosis><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MDR15><MTB infection><Macrophage><Macrophage Activation><Manuscripts><Mice><Mice Mammals><Microbe><Microscopy><Mig Receptor><Mig-R><MigR><Milk Growth Factor><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular><Murine><Mus><Mycobacterium tuberculosis><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Mφ><Null Mouse><Outcome><Pathogenesis><Pathway interactions><Patients><Physicians><Physiologic><Physiological><Platelet Transforming Growth Factor><Play><RNA Expression><Receptor Protein><Research><Research Resources><Resources><Role><STRL22><Scientist><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Site><Structure of parenchyma of lung><T cell regulation><T-Cell Activation><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><TB granuloma><TB immunity><TB infection><TB therapy><TB treatment><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><Techniques><Teff cell><Tertiary lymphoid structure><Testing><Tissues><Training><Transcription><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Tuberculosis><Vaccination><Vaccine Design><activate T cells><advanced analytics><bacterial disease treatment><bacterial infectious disease treatment><biological signal transduction><career><career advancement><career development><career transition><cell type><chemokine receptor><chemokine receptor 7><conditional knock-out><conditional knockout><developmental><disseminated TB><disseminated tuberculosis><effector T cell><experiment><experimental research><experimental study><experiments><flow cytophotometry><global health><host response><imaging><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immunity against M. tuberculosis><immunity against Mtb><immunity against Mycobacterium tuberculosis><immunity against TB><immunity against tuberculosis><immunity in tuberculosis><immunity to TB><immunity to tuberculosis><immunogen><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive response><improved><in vivo><infection due to Mycobacterium tuberculosis><innovate><innovation><innovative><lung pathogen><lymph cell><mouse model><mtb><murine model><necropsy><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><new vaccines><next generation therapeutics><next generation vaccines><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><novel vaccines><pathway><postmortem><pulmonary granuloma><pulmonary infections><pulmonary pathogen><receptor><receptor expression><response><single cell analysis><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><tertiary lymphoid organ><thymus derived lymphocyte><trafficking><treat M. tuberculosis><treat Mtb><treat Mycobacterium tuberculosis><treat tb><treat tuberculosis><treatment strategy><tuberculosis granuloma><tuberculosis immunity><tuberculosis infection><tuberculosis therapy><tuberculosis treatment><tuberculous spondyloarthropathy>
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Christoph Thomas Ellebrecht

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$173,340
FY 2026

Project Title

Asymmetric cell division for fate commitment of human T cells

Grant Number:

5K08AR080266-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Abstract Research: Asymmetric cell division is an evolutionarily conserved mechanism that affords self-renewal, differentiation and diversification of cell populations. It is unknown, however, if human T cells use this mechanism to induce distinct daughter cell fates. The proposed research w...

Research Terms

<Affect><Bioinformatics><Biology><Blood><Blood Reticuloendothelial System><Body Tissues><CAR T cells><CAR modified T cells><CAR-T><CAR-Ts><Cell Body><Cell Communication and Signaling><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Signaling><Cell division><Cells><Cellular biology><Cellular immunotherapy><Clinical><Color><Core Facility><Cutaneous Disorder><Data><Daughter><Dermatology><Dermatoses><Development><Development Plans><Differentiation in cell culture><Distal><Dysfunction><Effector Cell><Engineering><Environment><Expression Signature><FKHR><FOXO1><FOXO1A><FOXO1A gene><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Forkhead Box O1A><Forkhead in Rhabdomyosarcoma><Functional disorder><Funding><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profile><Gene Expression Profiling><Gene Transcription><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Transcription><Germany><Goals><Human><Human Engineering><Immune mediated therapy><Immunologically Directed Therapy><Immunotherapy><In Situ><In Vitro><In vitro cell differentiation><Infection><Inflammatory><Intermediary Metabolism><Intracellular Communication and Signaling><Investigators><Knowledge><Label><Laboratories><Laboratory Research><Length of Life><Longevity><M Phase><MHC Receptor><Major Histocompatibility Complex Receptor><Memory><Mentors><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Methods><Mice><Mice Mammals><Mitochondria><Mitosis><Mitosis Stage><Modern Man><Molecular><Murine><Mus><NIH><National Institutes of Health><Outcome><Pathway interactions><Pattern><Pennsylvania><Phenotype><Physicians><Physiopathology><Population><RNA Expression><Recombinant DNA Technology><Research><Research Personnel><Researchers><Residencies><Scientist><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Single cell seq><Skin><Skin Diseases><Skin Diseases and Manifestations><Skin Tissue><Structure><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell differentiation><T cell directed therapies><T cell immune therapy><T cell immunotherapy><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cells for CAR><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T memory cell><T-Cell Activation><T-Cell Antigen Receptors><T-Cell Receptor><T-Cell Receptor Interaction><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Subsets><T-cell therapeutics><T-cell transfer therapy><TCR Activation><TCR Interaction><Technology><Teff cell><Testing><Therapeutic><Tissues><Training><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><United States National Institutes of Health><Universities><Xenograft Model><activate T cells><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><analyze gene expression><biological signal transduction><career development><cell biology><cell sorting><cell-based immunotherapy><chimeric antigen T cell receptor><chimeric antigen receptor><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cells><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><chronic inflammatory skin><cutaneous disease><cutaneous tissue><daughter cell><dermal disease><dermal disorder><design><designing><developmental><differentiation in culture><differentiation in vitro><effector T cell><engineered T cells><exhaustion><experience><experiment><experimental research><experimental study><experiments><fatty acid oxidation><flow cytophotometry><gene expression analysis><gene expression assay><gene expression pattern><gene expression signature><gene manipulation><genetic manipulation><genetically engineered><genetically engineered T-cells><genetically manipulate><genetically perturb><human disease><human tissue><immune cell therapy><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunological synapse><improved><in vitro cellular differentiation><in vivo><innovate><innovation><innovative><lymph organ><lymphatic organ><lymphoid organ><memory T lymphocyte><metabolism measurement><metabolomics><metabonomics><mitochondrial><mouse model><murine model><notch><notch protein><notch receptors><novel><pathogen><pathophysiology><pathway><pharmacologic><post-doctoral training><pre-clinical><preclinical><programs><public health relevance><resident memory T cell><scRNA sequencing><scRNA-seq><self renewing cell><self-renew><self-renewal><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell next generation sequencing><single cell sequencing><single cell transcriptomic profiling><single-cell RNA sequencing><skin disorder><skin heterograft><skin xenograft><therapeutic T-cell platform><thymus derived lymphocyte><tissue resident memory T cell><transcriptional profile><transcriptional profiling><transcriptional signature><transgenic T- cells><xenograft transplant model><xenotransplant model>
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Alyssa Kriegermeier

LURIE CHILDREN'S HOSPITAL OF CHICAGO, CHICAGO, IL

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$163,012
FY 2026

Project Title

The Unfolded Protein Response in Murine and Pediatric Cholestatic Liver Diseases

Grant Number:

5K08DK132456-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/15/2024

End Date:

12/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Cholestatic liver diseases, including biliary atresia (BA), are the leading indication for pediatric liver transplant and there are no effective medical therapies for patients that decrease the need for transplantation. This is due, in part, to the lack of understanding of how the liver reacts to bi...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Agonist><Apoptosis><Apoptosis Pathway><Award><Basal Transcription Factor><Basal transcription factor genes><Bile Acids><Bile Duct Obstruction><Biliary Atresia><Biliary Stasis><Binding Proteins><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Stress><Cellular Stress Response><ChIP Sequencing><ChIP-seq><ChIPseq><Chemicals><Childhood><Childhood Injury><Chiro-Inositol><Cholalic Acids><Cholestasis><Cholic Acids><Chronic><Complex><DNA Binding><DNA Binding Interaction><DNA bound><DNA-Binding Proteins><Data><Data Analyses><Data Analysis><Degradation Pathway><Degradative Pathway><Development><Development Plans><Disease><Disease Progression><Disorder><ER stress><EXTMR><Endoplasmic Reticulum><Enzyme Gene><Enzymes><Ergastoplasm><Experimental Designs><Extramural><Extramural Activities><Funding><Future><Gene Action Regulation><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transfer><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Goals><Hepatic><Hepatic Cells><Hepatic Disorder><Hepatic Parenchymal Cell><Hepatic Transplantation><Hepatocyte><Hepatology><Human><Hydrophobicity><Immunoblotting><Impairment><Injections><Injury><Injury to Liver><Inositol><Intervention><Intracellular Communication and Signaling><Investigation><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Knowledge><Laboratories><Ligand Binding Protein><Ligand Binding Protein Gene><Liver><Liver Cells><Liver Grafting><Liver Transplant><Liver diseases><Mediating><Medical><Mentors><Mesoinositol><Metabolic Protein Degradation><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Network Analysis><Null Mouse><Outcome><Pathway Analysis><Pathway interactions><Patients><Pattern><Phenotype><Physicians><Programmed Cell Death><Protein Binding><Protein Turnover><Proteins><Publishing><RNA Seq><RNA sequencing><RNAseq><Reaction><Regulation><Regulatory Protein Degradation><Research><Research Training><Role><Scientist><Severities><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Techniques><Therapeutic><Therapeutic Intervention><Time><Tissues><Training><Transcription Factor Proto-Oncogene><Transcription factor genes><Translational Research><Translational Science><Transplantation><Tunicamycin><Universities><Western Blotting><Western Immunoblotting><aberrant folded protein><aberrant folded proteins><abnormal folded protein><abnormal folded proteins><adulthood><age associated alterations><age associated changes><age correlated alterations><age correlated changes><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age related alterations><age related changes><age specific alterations><age specific changes><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><bile acid metabolism><bile metabolism><bile obstruction><bile occlusion><biological signal transduction><bound protein><career><career development><cell stress><changes with age><child patients><cholestatic diseases><cholestatic disorder><cholestatic liver disease><cholestatic liver disorder><cholestatic syndromes><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><compare to control><comparison control><data interpretation><design><designing><developmental><disease control><disease model><disorder control><disorder model><endoplasmic reticulum stress><feeding><hepatic body system><hepatic damage><hepatic disease><hepatic injury><hepatic organ system><hepatopathy><human disease><injured child><injured children><injuries><injury in children><intervention therapy><lab experience><lab training><laboratory experience><laboratory training><lectures><liver damage><liver disorder><liver injury><liver transplantation><misfolded protein><misfolded proteins><mouse model><murine model><neonatal mice><neonate><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathway><pediatric><pediatric injury><pediatric patients><pharmacologic><post-natal development><postnatal><postnatal development><protein blotting><protein degradation><protein homeostasis><proteostasis><proteotoxic protein><proteotoxin><response><response to therapy><response to treatment><restoration><skills><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><therapeutic response><therapy response><transcription factor><transcriptome sequencing><transcriptomic sequencing><translation research><translational investigation><transplant><treatment response><treatment responsiveness>
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Jenny Zhen-Duan

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$161,190
FY 2026

Project Title

Adverse childhood experiences and alcohol misuse in Latino adolescents: testing biopsychosocial and cultural mechanisms.

Grant Number:

5K08AA029150-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/20/2022

End Date:

1/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Background. Latino adolescents have a higher prevalence of alcohol consumption and binge drinking, start using drugs and alcohol earlier, and are at greater risk of developing addiction due to early use. It has been well documented that adverse childhood experiences (ACEs), such as abuse and neglect...

Research Terms

<0-11 years old><Adherence><Adolescent><Adolescent Youth><Aeroseb-HC><Affect><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohol dependence><Alcoholism><Alcohols><Application Context><Area><Autoregulation><Award><Biologic Factor><Biological><Biological Factors><Biological Markers><Biometrics><Biometry><Biostatistics><Causality><Cetacort><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Collection><Communities><Consumption><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><DNA Methylation><Data><Data Analyses><Data Analysis><Data Collection><Dermacort><Development><Drug Therapy><Drug usage><Eldecort><Endocrine><Endocrinology><Ensure><Environment><Environmental Factor><Environmental Risk Factor><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><EtOH drinking><EtOH use><Etiology><Event><Exposure to><Family><Fortification><Foundations><Future><Genes><Genetic><Goals><HPA axis><Hair><Health><Health Services><Heavy Drinking><High Prevalence><Homeostasis><Hydrocortisone><Hydrocortone><Hytone><Individual><Intervention><Investigators><Knowledge><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><Link><Measures><Mediating><Mental Health><Mental Hygiene><Mentors><Mentorship><Metabolism and Endocrinology><Methylation><Modeling><NCMHD><NIAAA><NIMHD><National Center on Minority Health and Health Disparities><National Institute of Minority Health and Health Disparities><National Institute on Alcohol Abuse and Alcoholism><National Institute on Minority Health and Health Disparities><Nutracort><Outcome><Parents><Participant><Pathway interactions><Patient Self-Report><Pharmacological Treatment><Pharmacotherapy><Physiological Homeostasis><Prevention><Prevention Research><Proctocort><Psychological Health><Psychologist><Research><Research Personnel><Research Resources><Researchers><Resources><Risk><Role><Saliva><Sampling><Scientist><Self-Report><Stress><Structure><Substance Use Disorder><System><Testing><Time><Training><Work><abuse neglect><addiction><addictive disorder><adverse childhood events><adverse childhood experiences><alcohol addiction><alcohol dependency><alcohol dependent><alcohol epidemiology><alcohol ingestion><alcohol intake><alcohol misuse><alcohol product use><alcohol risk><alcohol use><alcohol use disorder><alcoholic beverage consumption><alcoholic drink intake><binge alcohol consumption><binge drinking><bio-markers><biologic><biologic marker><biological adaptation to stress><biological systems><biomarker><biopsychosocial><career><causation><childhood adversity><cohesion><community violence><contextual factors><data interpretation><developmental><disease causation><disease prevention><disorder prevention><drink heavily><drug intervention><drug treatment><drug use><environmental risk><epigenetically><episodic drinking><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol misuse><ethanol product use><ethanol use><ethanol use disorder><excessive alcohol consumption><excessive alcohol ingestion><excessive alcohol intake><excessive drinking><excessive ethanol ingestion><experience><extreme drinking><heavy alcohol use><high-risk adolescents><hypothalamic-pituitary-adrenal (HPA) axis><hypothalamic-pituitary-adrenal axis><hypothalmus-pituitary-adrenal axis><juvenile><juvenile human><kids><maltreatment><mistreatment><neglect and abuse><neighborhood violence><parent><pathway><pediatric><pediatric adversity><peer><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><prospective><protective factors><psychologic><psychological><psychosocial><reactioncrisis><resilience><resilient><social><social factors><social role><stress response><stressreaction><stressor><substance use><substance use and disorder><substance using><unhealthy alcohol use><violence against communities><youngster>
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John Weaver

CLEVELAND CLINIC LERNER COM-CWRU, CLEVELAND, OH

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$155,011
FY 2026

Project Title

Deep Learning of Renal Scans and Kidney Ultrasounds in Children with Antenatal Hydronephrosis

Grant Number:

5K08DK137042-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/15/2025

End Date:

1/31/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract The candidate for this K08 Career Development Award aims to become a leader and innovator in applying bioinformatics and computational research to the study of pediatric urologic diseases with the goal of improving patient outcomes. Antenatal hydronephrosis (ANH) is one of t...

Research Terms

<0-11 years old><AI system><Anatomic Sites><Anatomic structures><Anatomy><Artificial Intelligence><Award><Back><Bioinformatics><Bladder><Bladder Urinary System><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Child><Child Youth><Childhood><Children (0-21)><Children's Hospital><Clinic><Clinical><Computer Reasoning><Coupled><Data><Decision Making><Development><Diagnosis><Diagnostic><Diuretics><Doctor of Philosophy><Dorsum><Drainage><Drainage procedure><Early identification><Echography><Echotomography><Flank Pain><Gestation><Goals><Hospitals><Human><Hydronephrosis><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Infant><Institution><Inter-Observer Variability><Inter-Observer Variation><International><Interobserver Variability><Interobserver Variations><K-Awards><K-Series Research Career Programs><Kidney><Kidney Urinary System><Leanness><Learning><Machine Intelligence><Machine Learning><Medical Ultrasound><Mentors><Mentorship><Methodology><Modeling><Modern Man><Multimodal Imaging><Obstruction><Obstructive Uropathy><Operative Procedures><Operative Surgical Procedures><Output><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pattern><Pediatric Hospitals><Performance><Ph.D.><PhD><Philadelphia><Physicians><Population><Position><Positioning Attribute><Pregnancy><Process><Pyelonephritis><Randomized, Controlled Trials><Renal function><Research><Research Career Program><Research Infrastructure><Retrospective cohort study><Scanning><Secondary to><Site><Surgical><Surgical Interventions><Surgical Procedure><Techniques><Thinness><Time><Training><Ultrasonic Imaging><Ultrasonogram><Ultrasonography><Ultrasound Diagnosis><Ultrasound Medical Imaging><Ultrasound Test><Unnecessary Surgery><Ureteropelvic junction obstruction><Urinary Tract Diseases><Urine><Urologic Diseases><Urologic Disorder><Urological Diseases><Urological Disorders><Urologist><Work><Writing><antenatal><antepartum><career><clinical decision-making><clinical predictors><clinical significance><clinically significant><cohort><computer based prediction><deep learning><deep learning based model><deep learning method><deep learning model><deep learning strategy><design><designing><developmental><diagnostic ultrasound><experience><flasks><image-based method><imaging><imaging method><imaging modality><imaging study><implementation science><implementation study><improved><kidney function><kidney infection><kids><machine based learning><machine learning based method><machine learning method><machine learning methodologies><model building><multi-modal data><multi-modal datasets><multi-modal imaging><multi-modality><multi-modality imaging><multimodal data><multimodal datasets><multimodal modeling><multimodality><multimodality imaging><patient oriented outcomes><pediatric><predictive modeling><prenatal><pressure><quantitative imaging><randomized control trial><renal><skills><sonogram><sonography><sound measurement><standard of care><statistics><surgery><trial design><ultrasound><ultrasound imaging><ultrasound scanning><unborn><urinary bladder><urinary tract disorder><urinary tract obstruction><youngster>
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Stanislaw J Gabryszewski

CHILDREN'S HOSP OF PHILADELPHIA, PHILADELPHIA, PA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$150,165
FY 2026

Project Title

Modeling and prediction of allergic trajectories in children

Grant Number:

5K08AI182477-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/4/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT I seek to become an independent, NIH-funded academic allergist-immunologist and clinical research informatician invested in improving outcomes in pediatric allergy. To this end, I will utilize electronic health record (EHR) data to study developmental patterns of pediatric ...

Research Terms

<0-11 years old><21+ years old><AI based method><AI system><Accuracy of Diagnosis><Adult><Adult Human><Age><Age of Onset><Allergic><Allergic Disease><Allergic rhinitis><Allergic rhinitis due to allergen><Allergic rhinosinusitis><Allergic to food><Allergy><Allergy to food><Artificial Intelligence><Asthma><Atopic Dermatitis><Atopic Eczema><Atopic Neurodermatitis><Atopic rhinitis><Bioinformatics><Biological><Birth><Bronchial Asthma><Care Givers><Caregivers><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Children's Hospital><Chronic><Chronic Disease><Chronic Illness><Clinical><Clinical Data><Clinical Immunology><Clinical Management><Clinical Nutrition><Clinical Research><Clinical Study><Code><Coding System><Comparative Effectiveness Research><Complement><Complement Proteins><Computer Reasoning><Data><Data Bases><Data Set><Databases><Dedications><Demographic Factors><Descriptor><Development><Development Plans><Development and Research><Diagnosis><Diagnostic><Disease><Disease Progression><Disorder><Disseminated Neurodermatitis><Doctor of Philosophy><Electronic Health Record><Electronics><Ensure><Environment><Environmental Factor><Environmental Risk Factor><Eosinophilic Esophagitis><Epidemiology><Ethnic Origin><Ethnicity><Fellowship><Food Allergy><Food Hypersensitivity><Funding><Genetic><Goals><Health Care Providers><Health Personnel><Health system><Heterogeneity><IgE><Immunoglobulin E><Immunologist><Immunology><Incidence><Individual><Informatics><Institution><Interdisciplinary Research><Interdisciplinary Study><Investigators><Investments><Knowledge><Logistic Regressions><Machine Intelligence><Machine Learning><Maps><Measures><Mediating><Medical><Mentored Clinical Scientist Development Award (K08)><Mentored Clinical Scientists Development Award><Mentors><Mentorship><Methods><Modeling><Morbidity><Multidisciplinary Collaboration><Multidisciplinary Research><NIH><National Institutes of Health><Natural Language Processing><Nutritional status><Onset of illness><Outcome><Parturition><Patients><Pattern><Pediatric Hospitals><Pediatric cohort><Ph.D.><PhD><Phased Career Development><Philadelphia><Physicians><Population><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Predisposing Factor><Predisposition><Primary Care><Psychosocial Factor><Publications><Publishing><Questionnaires><R & D><R&D><Race><Races><Reporting><Research><Research Associate><Research Personnel><Research Proposals><Research Resources><Researchers><Residencies><Resources><Retrospective Studies><Rhinitis allergic atopic><Risk><Risk Factors><Scientific Publication><Scientist><Selection Bias><Severity of illness><Susceptibility><Symptoms><Testing><Training><United States National Institutes of Health><Urbanicity><Validation><Work><adulthood><ages><allergic dermatitis><allergic eczema><artificial intelligence method><biologic><biomed informatics><biomedical informatics><career><career development><certificate program><chronic disorder><clinical practice><clinical relevance><clinical translation><clinically relevant><clinically translatable><co-morbid><co-morbidity><cohort><comorbidity><complementation><computer based prediction><data base><demographics><detection method><detection procedure><detection technique><developmental><diagnostic accuracy><disease onset><disease risk><disease severity><disorder onset><disorder risk><electronic><electronic device><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><environmental risk><epidemiologic><epidemiological><experience><hazard><health care personnel><health care worker><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><improved outcome><individualized strategies><insight><kids><machine based learning><malleable risk><medical care providers><medical personnel><model development><model developments><modifiable risk><natural language understanding><novel><pediatric><personalization of treatment><personalized medicine><personalized strategies><personalized therapy><personalized treatment><post-doc><post-doctoral><post-doctoral trainee><predictive modeling><prevent><preventing><primary care practice><psychosocial variables><racial><racial background><racial origin><research and development><research associates><retrospective research study><retrospective survey><risk prediction algorithm><risk prediction model><sex><statistics><tool><treatment provider><validations><virtual><youngster>
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Youssef A Kousa

CHILDREN'S RESEARCH INSTITUTE, WASHINGTON, DC

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$53,999
FY 2026

Project Title

Viral Neurobiology in the Prenatal Brain

Grant Number:

3K08NS119882-04S1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/15/2022

End Date:

2/28/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT The prenatal brain is uniquely susceptible to viral infections. Such infections threaten 1 in 4 pregnancies and can cause severe neurodevelopmental disorders if not fetal demise. Different viruses lead to strikingly similar clinical outcomes due to overlapping viral neuropathology and the h...

Research Terms

<0-11 years old><Acquired brain injury><Affect><Alleles><Allelomorphs><Autophagocytosis><Biologic Models><Biological Models><Board Certification><Brain><Brain Injuries><Brain Nervous System><Candidate Disease Gene><Candidate Gene><Caring><Cell Function><Cell Physiology><Cell Process><Cellular Function><Cellular Physiology><Cellular Process><Cerebral Palsy><Child><Child Youth><Children (0-21)><Clinical><Complex><Critical Care><Data><Development><Development Plans><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Future Generations><Gene Expression><Genes><Genetic><Genomics><Gestation><Goals><Grant><Hospitals><Human><Individual><Infection><Lead><Life><Life Experience><Mechanistic Target of Rapamycin><Mentors><Mice><Mice Mammals><Model System><Modern Man><Murine><Mus><NIH><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><National Institutes of Health><Neonatal><Nerve Cells><Nerve Unit><Neural Cell><Neuro-epidemiology><Neurobiology><Neurocyte><Neurodevelopmental Disorder><Neuroepidemiology><Neurological Development Disorder><Neurologist><Neuronal Injury><Neurons><Neuropsychologies><Neuropsychology><Neurovirology><Organoids><Outcome><Pathway interactions><Pb element><Population><Position><Positioning Attribute><Precision therapeutics><Predisposition><Pregnancy><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><RAFT1><Regulation><Research><Research Infrastructure><Risk><Role><Scientist><Seasons><Seizure Disorder><Series><Subcellular Process><Susceptibility><System><Testing><Therapeutic Intervention><Titrations><Training><United States National Institutes of Health><Variant><Variation><Viral><Viral Diseases><Virus><Virus Diseases><Virus Replication><Work><autophagy><beta-Hexosaminidase><beta-N-Acetyl-D-hexosaminidase><beta-N-Acetyl-D-hexosaminide N-acetylhexosaminohydrolase><beta-N-Acetyl-hexosaminidase><beta-n-acetylhexosaminidase><brain damage><brain-injured><career development><critical injury><devastating injury><developmental><disability><epilepsia><epileptogenic><global developmental delay><heavy metal Pb><heavy metal lead><hexosaminidase><in vivo><intervention therapy><kids><mTOR><mammalian target of rapamycin><neurobiological><neurodevelopmental disease><neuron injury><neuronal><neuronal survival><neuropathologic><neuropathological><neuropathology><neuropsychologic><novel><pathway><post-natal development><postnatal development><precision medicine><precision therapies><precision treatment><precision-based medicine><prenatal><prevent><preventing><response><severe injury><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><unborn><viral infection><viral multiplication><viral replication><virus infection><virus multiplication><virus-induced disease><youngster><β-Hexosaminidase>
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THOMAS S. KUPPER

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 38/100
Training-friendly
Solid budget
Active award
$395,858
FY 2025

Project Title

Dermatology Training Grant

Grant Number:

5T32AR007098-51

Activity Code:

T32

Mechanism:

Training, Institutional

Agency:

NIH

Start Date:

9/1/1980

End Date:

5/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

The Harvard Medical School Department of Dermatology T32 training grant has been active for more than 45 years, and over that period of time has trained many postdoctoral fellows who have become national leaders in dermatology. Dr. Thomas Kupper has served as Principal Investigator since 2000. There...

Research Terms

<Dermatology><Grant><Training>
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Tamia Alisha Harris-Tryon

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Exploratory lead · 38/100
Very recent
Active award
Career award
$123,108
FY 2026

Project Title

Mentoring in Translational Research in Inflammatory Skin Disease

Grant Number:

1K24AR087610-01

Activity Code:

K24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/8/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Dr. Tamia Harris-Tryon is an Associate Professor in the Department of Dermatology at UT Southwestern Medical Center. She has established a successful and independent research program focused on elucidating mechanistically interactions between the immune system, the skin, and the micr...

Research Terms

<0-11 years old><21+ years old><5 alpha-Dihydrotestosterone><5-alpha-DHT><Address><Adult><Adult Human><Adult females><Adult women><Affect><Age><Androgen Antagonists><Androgen Receptor><Androgenic Agents><Androgenic Compounds><Androgens><Androstanolone><Anti-Androgen><Anti-Androgen Agents><Anti-androgen Therapy><Anti-androgen Treatment><Atopic Dermatitis><Atopic Eczema><Atopic Neurodermatitis><Award><B cell growth factor><B-Cell Differentiation Factor-1><B-Cell Growth Factor-1><B-Cell Growth Factor-I><B-Cell Proliferating Factor><B-Cell Stimulating Factor><B-Cell Stimulating Factor-1><B-Cell Stimulation Factor-1><B-Cell Stimulatory Factor-1><BCDF-1><BCGF><BCGF-1><BCSF 1><BSF-1><BSF1><Basic Research><Basic Science><Binetrakin><Blood Serum><Cardiac health><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Child><Child Youth><Children (0-21)><Chipmunk><Clinical><Clinical Trials><Cutaneous Disorder><Data><Data Set><Dermatologist><Dermatology><Dermatoses><Development><Dihydrotestosterone><Disease><Disorder><Disseminated Neurodermatitis><Drugs><Dysfunction><EASI><Endocrine Gland Secretion><Enrollment><Enzyme Gene><Enzymes><Epithelial Cell Aggregation and Separation><Evaluation><FDA approved><Faculty><Female><Females in adulthood><Foundations><Functional disorder><Funding><Future><Goals><Gonadal Steroid Hormones><Heart health><Hormone use><Hormones><Human><Hydroxysteroid Dehydrogenases><IL-13><IL-4><IL13><IL4 Protein><Immune><Immune system><Immunes><Immunity><Industry><Inflammation><Inflammatory><Interleukin-13><Interleukin-4><Interleukin-4 Precursor><Investigators><Itching><Journals><K-Awards><K-Series Research Career Programs><K24 Award><Leadership><Liquid Chromatography><Lymphocyte Stimulatory Factor 1><MCGF-2><Magazine><Mast Cell Growth Factor-2><Measurement><Measures><Medical center><Medication><Mentors><Mentorship><Methods><Mice><Mice Mammals><Microbe><Mid-Career Clinical Scientist Award (K24)><Modern Man><Murine><Mus><NIH><National Institutes of Health><Oral><Pathogenicity><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Patients><Pharmaceutical Preparations><Phenotype><Physiopathology><Position><Positioning Attribute><Production><Pruritic Disorder><Pruritis><Pruritus><QOL><Quality of life><Receptor Signaling><Reporting><Research><Research Career Program><Research Design><Research Personnel><Researchers><Sampling><Schools><Sebum><Sebums><Series><Serum><Severity of illness><Sex Hormones><Sex Steroid Hormones><Skin><Skin Diseases><Skin Diseases and Manifestations><Skin colonization><Spirolactone><Spironolactone><Stanolone><Study Type><Subcellular Process><Surface><System><T-Cell Growth Factor 2><Tamias><Testing><Testosterone><Therapeutic><Therapeutic Androgen><Therapeutic Androstanolone><Therapeutic Hormone><Therapeutic Testosterone><Time><Training><Trans-Testosterone><Translating><Translational Research><Translational Research Enterprise><Translational Science><United States National Institutes of Health><Verospirone><Women in adulthood><Women's cohort><Work><adulthood><ages><allergic dermatitis><allergic eczema><androgen inhibitor><antagonism><antagonist><associate faculty><associate professor><career><cohort><cohort in women><cohort on women><compare to control><comparison control><cutaneous barrier><cutaneous disease><cytokine><dermal barrier><dermal disease><dermal disorder><design><designing><developmental><disease severity><drug/agent><effective therapy><effective treatment><efficacy testing><enroll><epidermal barrier><experience><experiment><experimental research><experimental study><experiments><female cohort><female patients><gonadal steroids><human data><human subject><improved><indexing><itch sensation><kids><male><meter><mid-career faculty><midcareer faculty><mouse model><murine model><new marker><novel><novel biomarker><novel marker><pathophysiology><patient oriented research><patient oriented study><patients being female><patients being women><patients who are female><pharmacologic><programs><quality of sleep><research study><sex><sex steroid><skin barrier><skin disorder><sleep quality><study design><tandem mass spectrometry><translation research><translation research enterprise><translational investigation><translational research program><translational study><treatment strategy><women patients><youngster><♀><♂>
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Anand Kumar Rohatgi

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Exploratory lead · 38/100
Very recent
Active award
Career award
$122,720
FY 2026

Project Title

Mentoring Patient-Oriented Research in Deep Lipid Phenotyping for Cardiovascular Disease

Grant Number:

5K24HL146838-08

Activity Code:

K24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2019

End Date:

3/31/2029

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Dr. Anand Rohatgi is a Professor in the Department of Internal Medicine/Division of Cardiology at UT Southwestern Medical Center. He has established a successful and independent research program focused on elucidating the role of HDL metabolism in cardiovascular disease. His experien...

Research Terms

<ASCVD><Abscission><Adult-Onset Diabetes Mellitus><Affect><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antiatherogenic><Arteries><Asian group><Asian individual><Asian people><Asian population><Asians><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Award><Bangladesh><Blood Plasma><Blood Vessels><Canada><Cardiac health><Cardiac infarction><Cardiology><Cardiometabolic Disease><Cardiometabolic Disorder><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Carotid Artery Plaques><Cause of Death><Ceylon><Cholesterol><Clinic><Clinical><Code><Coding System><Complement><Complement Proteins><Deposit><Deposition><Development><Diabetes Mellitus><Diet><Diffuse><Disease><Disorder><Dysfunction><Educational workshop><Epidemiology><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Event><Excision><Exhibits><Extirpation><Faculty><Fats><Fatty acid glycerol esters><Fellowship><Functional disorder><Funding><Future><Gene variant><Genetic><Genomics><Genotype><Grant><HDL><HDL Lipoproteins><Heart><Heart Vascular><Heart failure><Heart health><Heavy Lipoproteins><Heterogeneity><High Density Lipoproteins><Human><Impairment><India><Individual><Industry><Inflammation><Insulin Resistance><Intermediary Metabolism><Internal Medicine><Investigators><K-Awards><K-Series Research Career Programs><Ketosis-Resistant Diabetes Mellitus><Leadership><Life Style><Lifestyle><Link><Lipids><Lipoproteins><Maturity-Onset Diabetes Mellitus><Measures><Mediator><Medical center><Mendelian randomization><Mentors><Mentorship><Metabolic Processes><Metabolism><Modern Man><Molecular><Myocardial Infarct><Myocardial Infarction><NHLBI><NIDDM><NIH><National Heart, Lung, and Blood Institute><National Institutes of Health><Nepal><Non-Hispanic><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Nonhispanic><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Not Hispanic or Latino><Pakistan><Paper><Particle Size><Pathway interactions><Phenotype><Physiopathology><Plasma><Plasma Serum><Population><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Predicting Risk><Preventive><Process><Proteins><Proteomics><Publishing><Removal><Research><Research Associate><Research Career Program><Research Personnel><Researchers><Reticuloendothelial System, Serum, Plasma><Risk Factors><Risk Marker><Role><Slow-Onset Diabetes Mellitus><South Asian><Sri Lanka><Stable Diabetes Mellitus><Surface><Surgical Removal><T2 DM><T2D><T2DM><Training><Translational Research Enterprise><Triacylglycerol><Triglycerides><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States National Institutes of Health><Variant><Variation><Woman><Work><Workshop><adjudication><adjudicative process and procedure><adult onset diabetes><allelic variant><alpha-Lipoproteins><atheromatosis><atheroprotection><atheroprotective><atherosclerosis risk><atherosclerotic disease><atherosclerotic heart disease><atherosclerotic risk><atherosclerotic vascular disease><cardiac disease risk><cardiac disorder risk><cardiac failure><cardiac infarct><cardiometabolic><cardiometabolic risk><cardiometabolism><cardioprotectant><cardioprotection><cardioprotective><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><career><carotid plaque><circulatory system><clinical relevance><clinical validation><clinically relevant><cohort><complementation><coronary artery calcium><coronary attack><coronary calcium><coronary infarct><coronary infarction><developmental><diabetes><diets><epidemiologic><epidemiological><ethnic subgroup><ethnicity group><exome sequencing><exome-seq><experience><fat metabolism><forecasting risk><genetic association><genetic variant><genome scale><genome-wide><genomewide><genomic variant><heart attack><heart disease risk><heart disorder risk><heart infarct><heart infarction><high risk><improved><insight><insulin resistant><insulin tolerance><ketosis resistant diabetes><lipid metabolism><maturity onset diabetes><meeting><meetings><metabolism measurement><metabolomics><metabonomics><new approaches><novel><novel approaches><novel strategies><novel strategy><particle><pathophysiology><pathway><patient oriented research><patient oriented study><post-doc><post-doctoral><post-doctoral trainee><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predicts risk><premature><prematurity><prevent><preventing><professor><programs><prospective><protein complex><research associates><resection><reverse cholesterol transport><risk prediction><risk predictions><risk predictor><risk predictors><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tenure process><tenure track><trait><translation research enterprise><translational investigator><translational research program><translational researcher><translational scientist><type 2 DM><type II DM><type two diabetes><vascular>
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A EDEN EVINS

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 36/100
Above-average budget
Active award
Career award
$533,472
FY 2025

Project Title

Career Development Program in Substance Use and Addiction Medicine

Grant Number:

5K12DA043490-08

Activity Code:

K12

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/30/2017

End Date:

6/30/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Training the next generation of clinician-investigators to conduct transformational, independent, patient- oriented addiction research that will improve the lives of those with addictive disorders is of the highest public health importance and is the primary goal of this MGH K12 Ment...

Research Terms

<Applications Grants><Chemical Dependence><Clinical><Clinical Research><Clinical Study><Collaborations><Dedications><Development and Research><Drug Addiction><Drug Dependence><Drug Dependency><Drug abuse><Ensure><Environment><Fostering><General Hospitals><Goals><Government><Grant Proposals><Group Meetings><History><Hospitals><Individual><Industry><Institution><Investigators><Joints><K12><K12 Award><K12 Mechanism><K12 Program><Laboratory Research><Leadership><Massachusetts><Medical><Medicine><Mentored Clinical Scientist Development Award (K08)><Mentored Clinical Scientist Development Program><Mentored Clinical Scientists Development Award><Mentors><Mentorship><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Paper><Phased Career Development><Postdoc><Postdoctoral Fellow><Productivity><Program Development><Psychiatry><Public Health><R & D><R&D><Recording of previous events><Research><Research Associate><Research Personnel><Research Resources><Researchers><Resources><Role><Scientist><Sight><Substance Addiction><Substance Dependence><Talents><Training><Training Programs><Vision><Work><Writing><abuse of drugs><abuses drugs><addiction><addictive disorder><career><career development><catalyst><design><designing><experience><histories><improved><interest><medical college><medical schools><member><multidisciplinary><next generation><patient centered><patient oriented><post-doc><post-doctoral><post-doctoral trainee><professor><programs><recruit><research and development><research associates><responsible research conduct><role model><school of medicine><skills><social role><substance use><substance using><training opportunity><visual function>
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NANCY A RIGOTTI

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 36/100
Above-average budget
Active award
Career award
$533,472
FY 2025

Project Title

Career Development Program in Substance Use and Addiction Medicine

Grant Number:

5K12DA043490-08

Activity Code:

K12

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/30/2017

End Date:

6/30/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Training the next generation of clinician-investigators to conduct transformational, independent, patient- oriented addiction research that will improve the lives of those with addictive disorders is of the highest public health importance and is the primary goal of this MGH K12 Ment...

Research Terms

<Applications Grants><Chemical Dependence><Clinical><Clinical Research><Clinical Study><Collaborations><Dedications><Development and Research><Drug Addiction><Drug Dependence><Drug Dependency><Drug abuse><Ensure><Environment><Fostering><General Hospitals><Goals><Government><Grant Proposals><Group Meetings><History><Hospitals><Individual><Industry><Institution><Investigators><Joints><K12><K12 Award><K12 Mechanism><K12 Program><Laboratory Research><Leadership><Massachusetts><Medical><Medicine><Mentored Clinical Scientist Development Award (K08)><Mentored Clinical Scientist Development Program><Mentored Clinical Scientists Development Award><Mentors><Mentorship><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Paper><Phased Career Development><Postdoc><Postdoctoral Fellow><Productivity><Program Development><Psychiatry><Public Health><R & D><R&D><Recording of previous events><Research><Research Associate><Research Personnel><Research Resources><Researchers><Resources><Role><Scientist><Sight><Substance Addiction><Substance Dependence><Talents><Training><Training Programs><Vision><Work><Writing><abuse of drugs><abuses drugs><addiction><addictive disorder><career><career development><catalyst><design><designing><experience><histories><improved><interest><medical college><medical schools><member><multidisciplinary><next generation><patient centered><patient oriented><post-doc><post-doctoral><post-doctoral trainee><professor><programs><recruit><research and development><research associates><responsible research conduct><role model><school of medicine><skills><social role><substance use><substance using><training opportunity><visual function>
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Robert Hyde

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$246,241
FY 2025

Project Title

Inner retinal dysfunction in retinitis pigmentosa

Grant Number:

5K08EY034211-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/30/2022

End Date:

6/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Abstract Retinitis pigmentosa (RP) is the most common group of inherited retinal diseases (IRDs), leading to progressive photoreceptor degeneration and blindness. In addition to well-studied outer retinal dysfunction in RP, there is a growing body of rigorous work highlighting cellular adapt...

Research Terms

<Amacrine Cells><Animal Model><Animal Models and Related Studies><Animals><Area><Attenuated><Basic Research><Basic Science><Biological Markers><Blindness><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Characteristics><Chicago><Clinic><Clinical><Clinical Investigator Award><Complement><Complement Proteins><Cone Photoreceptors><Coupling><Cyclicity><Data><Deafferentation><Deafferentation procedure><Dedications><Degenerative Disorder><Development><Development and Research><Doctor of Philosophy><Dysfunction><Electrophysiology><Electrophysiology (science)><Electroretinography><Environment><Ethics><Exhibits><Fellowship><Frequencies><Functional disorder><Future><Genetic><Goals><Hereditary><Illinois><Image><Inherited><Institution><Intracellular Communication and Signaling><Investigators><K08 Mechanism><K08 Program><Masks><Measures><Mediating><Mentors><Mentorship><Methods><Mice><Mice Mammals><Murine><Mus><Nature><Neurophysiology / Electrophysiology><Neurosciences><Noise><Operative Procedures><Operative Surgical Procedures><Ophthalmology><Outer pigmented layer of retina><Patients><Periodicity><Ph.D.><PhD><Pharmacology><Photoreceptor Cell><Photoreceptors><Photosensitive Cell><Physiopathology><Pigment cell layer of retina><Pigmentary Retinopathy><Pigmented layer of retina><Protocol><Protocols documentation><Psychophysics><R & D><R&D><Research><Research Personnel><Research Training><Researchers><Retina><Retinal Cone><Retinal Degeneration><Retinal Diseases><Retinal Disorder><Retinal Ganglion Cells><Retinal Pigment Epithelium><Retinal pigment epithelial cells><Retinitis Pigmentosa><Rhythmicity><Scientist><Sight><Signal Transduction><Signal Transduction Systems><Signaling><Source><Standard Model><Stimulus><Structure of retinal pigment epithelium><Surgical><Surgical Interventions><Surgical Procedure><Synaptic Potentials><Tapetoretinal Degeneration><Techniques><Testing><Therapeutic><Therapeutic Intervention><Time><Training><Training Programs><Translating><Translational Research><Translational Research Enterprise><Translational Science><Transmission><Universities><Vision><Visual Receptor><Work><attenuate><attenuates><bio-markers><biologic marker><biological signal transduction><biomarker><career><career development><cell type><clinical practice><complementation><cone cell><damage to retina><degenerative condition><degenerative disease><degenerative retina diseases><design><designing><developmental><effective therapy><effective treatment><electrophysiological><electroretinogram><ethical><experience><functional improvement><gangliocyte><ganglion cell><human subject><imaging><improve function><improved><improved functional outcomes><indexing><insight><intervention therapy><model of animal><mouse model><multidisciplinary><murine model><neural><novel><pathophysiology><pharmacologic><photoreceptor degeneration><postsynaptic><prevent><preventing><psychophysical><repair><repaired><research and development><response><restore sight><restore vision><retina degeneration><retina disease><retina disorder><retinal damage><retinal degenerative><retinal degenerative diseases><retinal ganglion><retinal neuron><retinopathy><rod and cone dystrophy><rod-cone dystrophy><sight restoration><skills><success><surgery><therapeutic target><translation research><translation research enterprise><translational investigation><translational research program><transmission process><trial design><vision loss><vision restoration><vision science><visual dysfunction><visual function><visual loss><visual science><visual stimulus>
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Anna Ruth Duncan

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$234,630
FY 2025

Project Title

Understanding the Role of EIF4A2 in Neurodevelopment

Grant Number:

5K08NS138691-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/10/2024

End Date:

7/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ ABSTRACT Neurodevelopmental disorders (NDD) are common, affecting 3% of the global population with emerging data suggesting that many are attributable to a genetic etiology. In the DEAD-box family of RNA Helicases, 18% of the genes have been shown to be important for neurodevelopmen...

Research Terms

<0-11 years old><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><ASD><Acute><Address><Advisory Committees><Affect><Aminalon><Aminalone><Assay><Autism><Autistic Disorder><Award><BUdR><Bioassay><Biologic Models><Biological Assay><Biological Models><Brachydanio rerio><Brain><Brain Nervous System><BrdU><Bromodeoxyuridine><Bromouracil Deoxyriboside><Broxuridine><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cas nuclease technology><Cell Body><Cells><Child><Child Youth><Children (0-21)><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complex><Connector Neuron><Cyclic Somatostatin><Cytoskeletal Gene><Cytoskeletal Proteins><Danio rerio><Data><Decreased Muscle Tone><Development><Differentation Markers><Differentiation Antigens><Differentiation Markers><Doctor of Philosophy><Drosophila><Drosophila genus><Dysfunction><EIF-1><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><Escalante syndrome><Eukaryotic Initiation Factor-1><Eukaryotic Initiation Factors><Eukaryotic Peptide Initiation Factor-1><Eukaryotic Peptide Initiation Factors><Eukaryotic Translation Initiation Factors><Event><Family><Fertilization><Fore-Brain><Forebrain><Fragile X><Fragile X Syndrome><Functional disorder><Future><GABA><Generations><Genes><Genetic><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Goals><Growth Hormone Inhibiting Factors><Growth Hormone-Inhibiting Hormone><Health Care Costs><Health Costs><Hour><Hypomyotonia><Hypotonia><Image><Immunoblotting><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impairment><In Situ Hybridization><Infantile Autism><Inherited Predisposition><Inherited Susceptibility><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intercalary Neuron><Intercalated Neurons><International><Interneurons><Internuncial Cell><Internuncial Neuron><Investigation><K-Awards><K-Series Research Career Programs><Kanner's Syndrome><Larva><Lead><Marker Antigens><Martin-Bell Syndrome><Martin-Bell-Renpenning syndrome><Mentors><Mentorship><Messenger RNA><Mice><Mice Mammals><Missense Mutation><Model System><Modeling><Movement><Murine><Mus><Muscle Hypotony><Muscle Tone Poor><Muscle hypotonia><Muscular Hypotonia><NIH><National Institutes of Health><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neurobiology><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Neurophysiology / Electrophysiology><Parvalbumins><Pathogenicity><Pb element><Peptide Initiation Factor EIF-1><Ph.D.><PhD><Phenotype><Physiopathology><Play><Poly(A) Tail><Population><Process><Progenitor Cells><Prosencephalon><Proteins><RNA Helicase><Renpenning syndrome 2><Reporter><Research><Research Career Program><Risk><Role><SOX6><SOX6 gene><SRIH><SRIH-14><SRY-Box 6><Scientist><Secondary to><Seizure Disorder><Seizures><Somatostatin><Somatostatin-14><Somatotropin Release Inhibiting Factors><Somatotropin Release-Inhibiting Hormone><Stem Cell Development><Swimming><System><Tail><Task Forces><Testing><Transgenic Organisms><Translational Inhibition><Translational Repression><Translations><United States National Institutes of Health><Variant><Variation><Western Blotting><Western Immunoblotting><X-linked mental deficiency-megalotestes syndrome><X-linked mental retardation with fragile X syndrome><X-linked mental retardation-fragile site 1 syndrome><Zebra Danio><Zebra Fish><Zebrafish><advisory team><autism spectral disorder><autism spectrum disorder><autism-fragile X (AFRAX) syndrome><autistic spectrum disorder><body movement><calbindin><calbindin 2><calretinin><career><career development><confocal imaging><developmental><electrophysiological><epilepsia><epileptogenic><fertilizations><fra(X) syndrome><fra(X)(28) syndrome><fra(X)(q27) syndrome><fra(X)(q27-28) syndrome><fragile X-mental retardation syndrome><fragile Xq syndrome><fragile site mental retardation 1><fruit fly><gain of function><gamma-Aminobutyric Acid><genetic etiology><genetic mechanism of disease><genetic vulnerability><genetically predisposed><global developmental delay><growth hormone release inhibiting factor><heavy metal Pb><heavy metal lead><imaging><improved><in situ Hybridization Genetics><in situ Hybridization Staining Method><in vivo><infant outcome><intellectual and developmental disability><kids><knock-down><knockdown><limited intellectual functioning><loss of function><mRNA><macro-orchidism-marker X (MOMX) syndrome><macro-orchidism-marker X syndrome><mar(X) syndrome><marker X syndrome><mental retardation-macroorchidism syndrome><migration><missense single nucleotide polymorphism><missense single nucleotide variant><missense variant><mutant><neurobiological><neurodevelopment><neurodevelopmental disease><neurogenesis><neurogenetics><neuronal><novel><overexpress><overexpression><pathophysiology><postmitotic><progenitor><progenitor cell development><progenitor cell differentiation><progenitor development><progenitor differentiation><protein blotting><protein expression><skills><social role><stem and progenitor cell development><stem and progenitor differentiation><stem cell differentiation><stem cells><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><timeline><transgenic><translation><youngster><α Tubulin><γ-Aminobutyric Acid>
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Joelle Payne Straehla

SEATTLE CHILDREN'S HOSPITAL, SEATTLE, WA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$230,947
FY 2025

Project Title

Investigating SLC46A3 as a negative regulator of nanoparticle drug delivery

Grant Number:

5K08CA277014-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/5/2024

End Date:

8/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Nanoparticle-based therapies have many potential advantages for treating cancer, but there are currently no clinical biomarkers to predict which patients are most likely to benefit from nanotherapeutics over conventional anticancer agents. To improve the efficacy of nanoparticles for...

Research Terms

<14-Hydroxydaunomycin><Acceleration><Address><Adriamycine><Advisory Committees><Anabolism><Anti-Cancer Agents><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Area><Autoregulation><Award><Biologic Models><Biological Markers><Biological Models><Body Tissues><Boston><Campto><Cancer Drug><Cancer Patient><Cancer Treatment><Cancer cell line><Cancers><Cell Body><Cell Line><CellLine><Cells><Characteristics><Chemicals><Childhood><Childhood Cancers><Children's Hospital><Clinic><Clinical Markers><Clinical Trials><Clinical stratification><DF/HCC><Dana-Farber Cancer Institute><Data><Dependence><Doxorubicin><Doxorubicina><Drug Delivery><Drug Delivery Systems><Drugs><Education><Educational aspects><Engineering><Environment><Ether Phosphatidates><FDA approved><Fatty Acids><Formulation><Future><Genetic><Genotype><Glycerol Phosphate Ethers><Glycerophosphate Ethers><Goals><Homeostasis><Hydroxyl Daunorubicin><Hydroxyldaunorubicin><Image><Impairment><In Vitro><Injections><Intermediary Metabolism><International><Investigation><Investigators><Knock-out><Knockout><Knowledge><Leadership><Link><Lipids><Liposomal><Liposomes><Malignant Cell><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant Tumor><Malignant childhood cancer><Massachusetts><Medication><Mentors><Mentorship><Metabolic Processes><Metabolism><Model System><Modeling><Molecular Transport><Nature><Neoplastic Disease Chemotherapeutic Agents><Neuroblastoma><Oncology><Oncology Cancer><Patients><Pediatric Hospitals><Pediatric Oncologist><Pediatric Oncology><Pharmaceutical Preparations><Phenotype><Phosphatides><Phospholipid Ethers><Phospholipid Metabolism><Phospholipids><Physicians><Physiological Homeostasis><Plasmalogens><Play><Position><Positioning Attribute><Preclinical data><Research><Research Personnel><Researchers><Role><Scientist><Specificity><Starvation><Strains Cell Lines><Stratification><Structure><Systems Biology><Task Forces><Technology><Testing><Therapeutic><Tissues><Training><Translations><Transport Process><Treatment Efficacy><Tumor Cell><Tumor-Specific Treatment Agents><Work><advisory team><anti-cancer drug><anti-cancer research><anti-cancer therapy><bio-markers><biologic marker><biomarker><biosynthesis><camptosar><cancer biomarkers><cancer cell><cancer cell metabolism><cancer in a child><cancer in children><cancer markers><cancer metabolism><cancer research><cancer therapy><cancer-directed therapy><career><child with cancer><childhood malignancy><clinical biomarkers><clinically useful biomarkers><cultured cell line><design><designing><drug/agent><experience><fat metabolism><functional genomics><imaging><improved><in vivo><insight><interest><intervention efficacy><irinotecan><lipid based nanoparticle><lipid metabolism><lipid nanoparticle><liposomal delivery><liposomal formulation><liposomal preparation><liposome delivery><malignancy><nano><nano medicinal><nano medicine><nano particle><nano particle delivery><nano therapy><nano-sized particle><nanocarrier><nanomaterials><nanomedicinal><nanomedicine><nanoparticle><nanoparticle delivered><nanoparticle delivery><nanoparticle drug><nanoparticle therapy><nanosized particle><nanotherapeutic><nanotherapy><nanovessel><neoplasm/cancer><neoplastic cell><pediatric><pediatric cancer><pediatric malignancy><pre-clinical><preclinical><preclinical findings><preclinical information><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><programs><response><skills><social role><solute><specific biomarkers><targeted agent><therapeutic efficacy><therapeutic nanoparticles><therapy efficacy><tool><trafficking><translation><tumor><tumor cell metabolism><tumor metabolism><uptake>
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Mayuko Ito Fukunaga

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$229,988
FY 2025

Project Title

Facilitation of Information Exchange for Shared Decision Making for Lung Cancer Screening

Grant Number:

5K08CA283304-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/24/2023

End Date:

6/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT I am a pulmonary critical care physician at the UMass Chan Medical School and a former scholar of the Massachusetts Consortium for Cardiopulmonary Implementation Science program funded by an NIH K12 award. My long-term goal is to be an implementation scientist with expertise in applying hea...

Research Terms

<Active Follow-up><Adherence><Agreement><Anxiety><Award><Awareness><Benefits and Risks><Cancer Cause><Cancer Control><Cancer Control Science><Cancer Etiology><Cardiopulmonary><Cessation of life><Characteristics><Clinic Visits><Clinical><Clinical Informatics><Comparison arm><Consumption><Critical Care><Data><Data Collection><Death><Development><Education><Educational aspects><Electronic Health Record><Electronics><Eligibility><Eligibility Determination><Enrollment><Ensure><Equity><Evaluation><Evidence based practice><Feedback><Fostering><Foundations><Funding><Future><Goals><Grant><Health Care Professional><Health Informatics><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Health Professional><Individual><Internet><Interview><K12><K12 Award><K12 Mechanism><K12 Program><Knowledge><Language><Malignant Tumor of the Lung><Malignant neoplasm of lung><Massachusetts><Measures><Medicare><Mentored Clinical Scientist Development Program><Mentors><Mentorship><Mission><Motivation><NIH><National Institutes of Health><Older Population><PRISM framework><PRISM model><Patient Care><Patient Care Delivery><Patients><Physicians><Pilot Projects><Population><Practical Robust Implementation and Sustainability Model><Pragmatic, Robust Implementation and Sustainability Model><Protocol Screening><Provider><Public Health Informatics><Pulmonary Cancer><Pulmonary malignant Neoplasm><Quasi-experiment><Quasi-experimental analysis><Quasi-experimental approach><Quasi-experimental design><Quasi-experimental methods><Quasi-experimental research><Quasi-experimental study><Quasi-experimental technique><Radiation exposure><Randomized><Recommendation><Research><Research Design><Rural Community><Sampling><Scientist><Smoking History><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Structure><Study Type><Survey Instrument><Surveys><System><Technology><Testing><Text Messaging><Time><Title 18><Training><U.S. Preventative Services Task Force><U.S. Preventative Task Force><U.S. Preventive Services Task Force><U.S. Preventive Task Force><US Preventative Services Task Force><US Preventative Task Force><US Preventive Health Services Task Force><US Preventive Services Task Force><US Preventive Task Force><USPSTF><United States><United States National Institutes of Health><United States Preventative Services Task Force><United States Preventative Task Force><United States Preventive Services Task Force><United States Preventive Task Force><Visit><WWW><Work><active followup><arm><automated text message><automated texting><barriers to implementation><cancer prevention><care as usual><care for patients><care of patients><caring for patients><clinical investigation><cognitive interview><comparator arm><consumer informatics><design><designing><developmental><electronic><electronic device><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><enroll><experience><follow up><follow-up><followed up><followup><health communication><health insurance for disabled><health literacy><high risk group><high risk individual><high risk people><high risk population><implementation barriers><implementation challenges><implementation science><implementation strategy><implementation study><improved><informant><innovate><innovation><innovative><low SES><low socio-economic position><low socio-economic status><low socioeconomic position><low socioeconomic status><lung cancer><lung cancer early detection><lung cancer prevention><lung cancer screening><m-Health><mHealth><medical college><medical schools><mobile health><mortality><older groups><older individuals><older person><pack/year><pilot study><pilot test><pragmatic effectiveness trial><pragmatic trial><preference><primary care clinic><primary care provider><primary care setting><primary care visit><programs><providers from primary care><providers of primary care><pulmonary><randomisation><randomization><randomly assigned><school of medicine><screening uptake><shared decision making><short message service><skills><sms messaging><statistical analysis><strategies for implementation><study design><texting><tool><treatment as usual><uptake><usability><user centered design><usual care><web><world wide web>
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Kevin Young Xu

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$196,236
FY 2025

Project Title

Using Big Data to Optimize Treatment of Opioid Use Disorder in Pregnancy

Grant Number:

5K08DA061258-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2024

End Date:

7/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY I am an early career investigator in the fields of pharmacoepidemiology, population health, and addiction psychiatry. My overarching career goal is to become an independently funded researcher dedicated to investigating the real-world effectiveness of addiction medications so that we...

Research Terms

<Access to Care><Adanon><Address><Affect><Althose><American><Area><Award><Big Data><BigData><Buprenorphine><Centers for Medicare and Medicaid Services><Characteristics><Clinical><Clinical Data><Clinical Trials><Communities><Data><Data Science><Dedications><Dolophine><Drug Prescribing><Drug Prescriptions><Drug Therapy><Drugs><Effectiveness><Ensure><FDA approved><Funding><Future><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Geography><Gestation><Goals><Health Care Financing Administration><Health Services Accessibility><Individual><Intervention><Investigators><Knowledge><Life><Link><Literature><Location><Measures><Mediating><Mediation><Medicaid><Medicaid services><Medication><Mentorship><Methadone><Methadose><Methods><Modeling><NIDA><Nalorex><Naltrexone><National Institute of Drug Abuse><National Institute on Drug Abuse><Nature><Negotiating><Negotiation><Nemexin><Overdose><Overdose reduction><Patients><Pattern><Personalized medical approach><Pharmaceutical Epidemiology><Pharmaceutical Preparations><Pharmacoepidemiology><Pharmacological Treatment><Pharmacotherapy><Physicians><Policy Maker><Population><Pregnancy><Pregnancy Complications><Proxy><Psychiatry><Public Health><ReVia><Research><Research Personnel><Researchers><Risk><Rural><System><Testing><Training><Treatment Effectiveness><Treatment outcome><United States><United States Centers for Medicare and Medicaid Services><United States Health Care Financing Administration><Vivitrol><Work><access to health services><access to medications><access to services><access to treatment><accessibility to health services><addiction><addictive disorder><availability of services><buprenorphine treatment><care access><career><career development><community factor><community-level factor><comparative effectiveness><comparative effectiveness study><comparative safety><compare effectiveness><complications during pregnancy><death among pregnant><death during pregnancy><develop therapy><drug abuse prevention><drug addiction prevention><drug epidemiology><drug intervention><drug treatment><drug use prevention><drug/agent><experience><geographic difference><geographic site><geographic variation><health determinants><health service access><health services availability><improved><individualized approach><interest><intervention development><medication access><medication prescription><methadone center><methadone clinic><methadone clinic/center><methadone maintenance><methadone maintenance program><methadone maintenance therapy><methadone maintenance treatment><methadone treatment><mortality during pregnancy><mortality in pregnancy><novel><obstetric mortality><opiate crisis><opiate use disorder><opioid crisis><opioid epidemic><opioid use disorder><outreach><overdose risk><personalized approach><pharmaceutical intervention><pharmacoepidemiologic><pharmacoepidemiological><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><population based><population health><precision approach><pregnancy associated death><pregnancy associated maternal death><pregnancy associated mortality><pregnancy death><pregnancy mortality><pregnancy related death><pregnancy related maternal death><pregnancy related mortality><pregnancy-related complications><pregnant><prescribed medication><prevent><prevent drug abuse><prevent drug addiction><prevent drug use><preventable death><preventable mortality><preventing><protective effect><psychologic><psychological><reduce overdose><reduction in overdose><research study><rural area><rural location><rural region><service availability><tailored approach><therapy development><therapy optimization><treatment access><treatment development><treatment optimization><uptake><waiver>
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GEORGE ENG

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$196,204
FY 2025

Project Title

Differential Wnt Dependencies in Colon Epithelium.

Grant Number:

5K08CA277011-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2023

End Date:

8/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract This proposal details a five-year training plan for the development of a research program focused on elucidating the therapeutic potential of superimposed additional Wnt signaling on colonic neoplasia. The molecular driver shared across the vast majority of colonic neoplasms...

Research Terms

<APC - Adenomatous Polyposis Coli><APC Protein><APC gene><APC genes><APC mutation><APC tumor suppressor><ATP-protein phosphotransferase><Adenocarcinoma><Adenomatosis Polyposis Coli Gene><Adenomatous Polyposis Coli><Adenomatous Polyposis Coli Protein><Adenomatous Polyposis Coli mutation><Advisory Committees><Affect><Agonist><Allelic Loss><Antioncogene Protein p53><Assay><Award><Beta Cadherin-Associated Protein><Beta-1 Catenin><Bioassay><Biological Assay><Biomedical Engineering><C-K-RAS><CRISPR interference><CRISPR-dCas9-mediated repression><CRISPR/dCas9 interference><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRi><CUL-2><Caliber><Cancer Biology><Cancer Model><CancerModel><Cancers><Carcinoma><Cell Body><Cell Communication and Signaling><Cell Function><Cell Growth in Number><Cell Multiplication><Cell Nucleus><Cell Physiology><Cell Process><Cell Proliferation><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Proliferation><Cellular Tumor Antigen P53><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats interference><Colon><Colon Adenocarcinoma><Colon Cancer><Colon Carcinoma><Colon Neoplasms><Colon Tumor><Colonic Adenocarcinoma><Colonic Adenoma><Colonic Adenomatous Polyp><Colonic Mass><Colonic Neoplasms><Colonic Tumor><Colorectal Cancer><Complex><DNA mutation><DP2.5><Data><Dependence><Development Plans><Diet><Dose><Elements><Engineering><Ensure><Epithelial cancer><Epithelium><Essential Genes><Exhibits><Foundations><Frequencies><GI Stem cell><GSK-3><General Hospitals><Generalized Growth><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Glycogen Synthase Kinase 3><Growth><History><Human><Institution><Intestinal><Intestines><Intracellular Communication and Signaling><K-RAS2A><K-RAS2B><K-Ras><K-Ras 2A><K-Ras-2 Oncogene><KRAS><KRAS2><KRAS2 gene><Ki-RAS><Kinase Family Gene><Knock-out><Knockout><Lesion><Location><Loss of Heterozygosity><Maintenance><Malignant Adenoma><Malignant Epithelial Neoplasms><Malignant Epithelial Tumors><Malignant Neoplasms><Malignant Tumor><Massachusetts><Medical><Mentors><Mice><Mice Mammals><Modeling><Modern Man><Moderna COVID-19 vaccine><Moderna coronavirus disease 2019 vaccine><Molecular><Murine><Mus><Mutate><Mutation><Normal Cell><Normal Tissue><Normal tissue morphology><Nucleus><Oncogene K-Ras><Oncogenic><Oncoprotein p53><Organoids><P53><PLYPCMY><PRO2286><Pathologist><Pathway interactions><Patients><Phosphoprotein P53><Phosphoprotein pp53><Physicians><Polypectomy><Pre-Clinical Model><Preclinical Models><Protein Kinase><Protein TP53><Proteins><RASK2><RNA Seq><RNA sequencing><RNAseq><Recording of previous events><Research><Research Resources><Research Specimen><Resources><Rho-associated kinase><Rho-kinase><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Specimen><Spikevax><Stereotyping><Subcellular Process><TP53><TP53 gene><TRP53><Task Forces><Technology><Therapeutic><Time><Tissue Growth><Toxic effect><Toxicities><Training><Tumor Cell><Tumor Protein p53><Tumor Protein p53 Gene><WNT Signaling Pathway><WNT signaling><Wnt proteins><Work><adenoma><advisory team><beta cat><beta catenin><bio-engineered><bio-engineers><bioengineering><biological engineering><biological signal transduction><bowel><cancer in the colon><clinical care><colon adenoma><colon adenomatous polyp><colon cancer therapy><colon cancer treatment><colon neoplasia><diets><epithelial carcinoma><gastrointestinal stem cell><gene editing platform><gene editing system><gene editing technology><gene editing tools><gene-editing toolkit><genome mutation><glycogen synthase a kinase><gsk-3 Gene Product><gut progenitor><gut stem cell><histories><human model><hydroxyalkyl protein kinase><improved><in vivo><inhibitor><intestinal progenitor><intestinal stem cells><knock-down><knockdown><loss of function><loss of function mutation><mRNA-1273><mRNA1273><malignancy><model of human><mouse model><murine model><mutant><nano particle><nano particle delivery><nano-sized particle><nanoparticle><nanoparticle delivered><nanoparticle delivery><nanosized particle><neoplasm/cancer><neoplastic cell><novel><ontogeny><p53 Antigen><p53 Genes><p53 Tumor Suppressor><pathway><pharmacologic><phosphorylase b kinase kinase><progenitor><programs><protein p53><repressing CRISPR-dCas9 system><small molecular inhibitor><small molecule inhibitor><success><synthetic lethal interaction><synthetic lethality><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transcriptome sequencing><transcriptomic sequencing><transcriptomics><tumor><tumor growth><v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog><β-catenin>
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Hyejeong Hong

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$194,940
FY 2025

Project Title

Macrophage Expression Quantitative Trait Loci and Tuberculosis Pathogenesis

Grant Number:

1K08AI182475-01A1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/12/2025

End Date:

7/31/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Despite continuous efforts to eradicate tuberculosis (TB), Mycobacterium tuberculosis (Mtb) is still the leading infectious agent worldwide. Most people heavily exposed to Mtb become infected and develop latent Mtb infection (LTBI). Importantly, Dr. Hong’s collaborators identified ~7% of individuals...

Research Terms

<(TNF)-α><Alleles><Allelomorphs><Alveolar Macrophages><Assay><Autophagocytosis><Award><B-Cell Differentiation Factor Gene><B-Cell Stimulatory Factor 2 Gene><BSF-2 Gene><BSF2 Gene><Beta Proprotein Interleukin 1><Beta-2 Gene Interferon><Bioassay><Biological Assay><Blood monocyte><CRISPR><CRISPR/Cas system><Cachectin><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Communication and Signaling><Cell Line><Cell Signaling><CellLine><Cellular Immunology><Clinical><Clinical Research><Clinical Study><Clustered Regularly Interspaced Short Palindromic Repeats><Communicable Diseases><Cytokine Signal Transduction><Cytokine Signaling><Data><Diagnostic><Disease><Disease Progression><Disorder><Doctor of Philosophy><Drug resistance in Mtb><Drug resistance in Mycobacterium Tuberculosis><Drug resistant M Tuberculosis><Drug resistant Mtb><Drug resistant Mycobacteria Tuberculosis><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiology><Epidemiology Research><Exposure to><Gene Expression><Genes><Genetic><Genetic Determinism><Genetic Diversity><Genetic Variation><Goals><HSF Gene><Hepatocyte Stimulatory Factor Gene><Heterogeneity><Household><Human Genetics><Hybridoma Growth Factor Gene><IFNB2 Gene><IL-1 beta><IL-1 β><IL-1-b><IL-1β><IL-6 Gene><IL1-Beta><IL1-β><IL1B Protein><IL1F2><IL1β><IL6><IL6 gene><Immune><Immunes><Immunity><Immunogenetics><Individual><Infectious Agent><Infectious Diseases><Infectious Disorder><Inflammatory><Inflammatory Response><Interleukin 1beta><Interleukin 6 (Interferon, Beta 2) Gene><Interleukin-1 beta><Interleukin-1β><Interleukin-6 Gene><Intracellular Communication and Signaling><Investigators><K-Awards><K-Series Research Career Programs><Knowledge><Lung Inflammation><Lung TB><Lung Tuberculosis><M . tuberculosis resistance><M tb><M tuberculosis><M tuberculosis infection><M. tb><M. tb infection><M. tuberculosis><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><Macrophage><Macrophage-Derived TNF><Maps><Marrow monocyte><Measures><Mediating><Mentors><Mentorship><Monocyte-Derived TNF><Mtb drug resistance><Mtb resistance><Mycobacterium tuberculosis><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Mycobacterium tuberculosis resistance><Myeloid Cells><Mφ><Outcome><Pathogenesis><Pathway interactions><Patients><Pattern><Pennsylvania><Persons><Ph.D.><PhD><Phagocytosis><Phagosomes><Phenotype><Play><Pneumonitis><Position><Positioning Attribute><Predisposing Factor><Predisposition><Preinterleukin 1 Beta><Pulmonary Inflammation><Pulmonary Macrophages><Pulmonary TB><Pulmonary Tuberculosis><QTL><Quantitative Microscopy><Quantitative Trait Loci><RNA Seq><RNA sequencing><RNAseq><Regulation><Regulatory Element><Research><Research Career Program><Research Personnel><Researchers><Resistance><Risk><Role><School Health Nursing><School Nursing><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Single Base Polymorphism><Single Nucleotide Polymorphism><Site><Strains Cell Lines><Susceptibility><TB infection><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Testing><Therapeutic><Time><Training><Translating><Tuberculosis><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Uganda><Universities><Variant><Variation><Viet Nam><Vietnam><anti-microbial><antimicrobial><autophagy><biological signal transduction><clinical epidemiology><clinical phenotype><cohort><cultured cell line><cytokine><diagnostic approach><diagnostic strategy><disseminated TB><disseminated tuberculosis><drug resistance M Tuberculosis><drug resistance Mycobacteria Tuberculosis><drug resistant M.tb><epidemiologic><epidemiologic investigation><epidemiological><epidemiology study><gene locus><gene signatures><genetic approach><genetic determinant><genetic locus><genetic signature><genetic strategy><genomic location><genomic locus><iPS><iPSC><iPSCs><indexing><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><infection due to Mycobacterium tuberculosis><infectious organism><insight><medical college><medical schools><monocyte><mtb><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathogen><pathway><professor><protective factors><resistance in M . tuberculosis><resistance in Mycobacterium tuberculosis><resistant><resistant M . tuberculosis><resistant Mtb><resistant Mycobacterium tuberculosis><response><school of medicine><screening><screenings><single nucleotide variant><skills><social role><tool><transcriptome sequencing><transcriptomic sequencing><translational immunology><treatment strategy><tuberculosis infection><tuberculous spondyloarthropathy>
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Emily Hunt Olfson

YALE UNIVERSITY, NEW HAVEN, CT

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$193,860
FY 2025

Project Title

Neurogenomic Investigations of Trichotillomania and Excoriation Disorder

Grant Number:

5K08MH128665-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/1/2022

End Date:

6/30/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Trichotillomania (hair pulling) and excoriation (skin picking) disorder are debilitating, difficult-to-treat obsessive-compulsive disorder (OCD) spectrum conditions with no first-line pharmacologic interventions. Previous work supports the role of shared genetic factors in ...

Research Terms

<0-11 years old><1st degree relative><ASD><Area><Autism><Autistic Disorder><Award><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biological><Biology><Brain><Brain Nervous System><Candidate Disease Gene><Candidate Gene><Child><Child Rearing><Child Youth><Children (0-21)><Conditioning Therapy><Copy Number Polymorphism><DNA Damage><DNA Injury><DNA Sequence><DNA mutation><DNA seq><DNA sequencing><DNAseq><Data><Development><Disabling><Disease><Disorder><Distress><Drug Therapy><Early Infantile Autism><Encephalon><Ensure><Excoriation><First Degree Relative><Functional impairment><Gene variant><Genes><Genetic><Genetic Change><Genetic Risk><Genetic defect><Genetic mutation><Genomic approach><Genomics><Gilles de la Tourette syndrome><Gilles de la Tourette's Disease><Glutamates><Goals><Guinon's disease><Hair><Hereditary><Hour><Individual><Infantile Autism><Inherited><Investigation><Investigators><Kanner's Syndrome><Knowledge><L-Glutamate><Mentors><Mutation><Nerve Impulse Transmission><Nerve Transmission><Network Analysis><Neurobiology><Neuronal Transmission><Obsessive-Compulsive Disorder><Obsessive-Compulsive Neurosis><Organoids><Outcome><Parenting><Parenting behavior><Parents><Pathway Analysis><Pathway interactions><Patients><Pattern><Pharmacological Treatment><Pharmacotherapy><Physicians><Population><Public Health><Publishing><Recurrence><Recurrent><Research><Research Personnel><Researchers><Risk><Risk-associated variant><Role><Scientist><Series><Skin><Synapses><Synaptic><Systems Analyses><Systems Analysis><Techniques><Testing><Tic Disorder, Combined Vocal and Multiple Motor><Tourette Syndrome><Tourette's><Tourette's Disease><Tourette's Disorder><Tourette's Syndrome><Training><Trichotillomania><Variant><Variation><Work><allelic variant><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><axon signaling><axon-glial signaling><axonal signaling><behavior intervention><behavioral intervention><biologic><brain cell><career><childrearing><cohort><compare to control><comparison control><copy number variant><copy number variation><de novo mutation><de novo variant><developmental><differential expression><differentially expressed><drug intervention><drug treatment><effective therapy><effective treatment><excitatory neuron><exome><exome sequencing><exome-seq><experience><gene network><genetic variant><genome mutation><genome scale><genome wide analysis><genome wide studies><genome-wide><genome-wide analysis><genome-wide identification><genomewide><genomic effort><genomic strategy><genomic variant><glia signaling><glial signaling><glutamatergic><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><inhibitory neuron><innovate><innovation><innovative><insight><kids><maladie des tics><medical complication><multidisciplinary><nerve signaling><neural><neural signaling><neurobiological><neurogenetics><neurogenomics><neuronal signaling><neuropsychiatric><neuropsychiatry><neurotransmission><novel><parent><pathway><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><programs><repetitive behavior><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><scRNA sequencing><scRNA-seq><sex><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><structural mutation><structural variant><structural variation><success><synapse><tic de Guinon><transcriptional differences><transcriptomics><variant detection><youngster>
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Stephen Matthew Carpenter

CASE WESTERN RESERVE UNIVERSITY, CLEVELAND, OH

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$193,320
FY 2025

Project Title

Determining Protective Features of Human Memory T-cells to Inform Mycobacterium tuberculosis Vaccine Development

Grant Number:

5K08AI163407-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/11/2022

End Date:

7/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary / Abstract Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (Mtb), is a disease that kills 1.4 million people every year. There is no reliable vaccine to prevent TB, yet many latently-infected individuals are protected from progressing to active TB despite heav...

Research Terms

<21+ years old><AIDS Virus><Acceleration><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Adolescent><Adolescent Youth><Adult><Adult Human><Animal Model><Animal Models and Related Studies><Antigens><Autologous><Avidity><Benchmarking><Best Practice Analysis><Bioinformatics><Biologic Models><Biological Models><Bronchoalveolar Lavage Fluid><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cell Function><Cell Isolation><Cell Physiology><Cell Process><Cell Protection><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular biology><Cessation of life><Chronic><Clinical><Clinical Investigator Award><Clinical Research><Clinical Study><Co-culture><Cocultivation><Coculture><Coculture Techniques><Collaborations><Communicable Diseases><Communities><Cytoprotection><Data><Death><Development><Disease><Disorder><Environment><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Frequencies><Funding><Goals><HIV><Household><Human><Human Immunodeficiency Viruses><Immune><Immunes><Immunologist><Immunology><Individual><Infection><Infectious Diseases><Infectious Disorder><Institution><Investigators><K08 Mechanism><K08 Program><LAV-HTLV-III><Learning><Link><Long-term infection><Lung><Lung Respiratory System><Lymphadenopathy-Associated Virus><Lymphatic cell><Lymphocyte><Lymphocytic><M tb><M tuberculosis><M tuberculosis antigen><M tuberculosis infection><M. tb><M. tb infection><M. tuberculosis><M. tuberculosis antigen><M. tuberculosis infection><M.tb antigen><M.tb infection><M.tuberculosis infection><MHC Receptor><MTB infection><MTB vaccine><Macrophage><Major Histocompatibility Complex Receptor><Mentors><Model System><Modern Man><Mtb antigen><Mycobacterium tuberculosis><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis antigens><Mycobacterium tuberculosis infection><Mφ><Peptide-MHC><Peptide-Major Histocompatibility Protein Complex><Peptide/MHC Complex><Peptides><Persons><Phenotype><Physicians><Position><Positioning Attribute><Predisposition><Preparation><Prevention><RNA Seq><RNA sequencing><RNAseq><Research><Research Personnel><Research Priority><Researchers><Severities><Specificity><Subcellular Process><Susceptibility><System><T cell response><T memory cell><T-Cell Antigen Receptor Specificity><T-Cell Antigen Receptors><T-Cell Depletion><T-Cell Receptor><T-Cell Receptor Specificity><T-Cells><T-Lymphocyte><T-cell depletion therapy><T-lymphocyte depletion therapy><T4 Cells><T4 Lymphocytes><TB infection><TB vaccine><Teff cell><Testing><Training><Translational Research><Translational Science><Tuberculosis><Tuberculosis Vaccines><Uganda><Universities><Vaccine Design><Vaccine for TB><Vaccine for Tuberculosis><Vaccines><Virus-HIV><Work><adulthood><anti-TB vaccine><antigen-specific T cells><benchmark><cell biology><cell sorting><chronic infection><cohort><cytokine><cytoprotective><develop a vaccine><develop vaccines><development of a vaccine><developmental><disseminated TB><disseminated tuberculosis><effector T cell><experience><experiment><experimental research><experimental study><experiments><fighting><flow cytophotometry><immunogen><improved><infection due to Mycobacterium tuberculosis><juvenile><juvenile human><lymph cell><medical college><medical schools><memory CD4 T cell><memory CD4 T lymphocyte><memory T lymphocyte><model of animal><mouse model><mtb><murine model><pMHC><persistent infection><preparations><prevent><preventing><programs><recruit><risk stratification><scRNA sequencing><scRNA-seq><school of medicine><single cell RNA-seq><single cell RNAseq><single cell analysis><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><stratify risk><thymus derived lymphocyte><transcriptome sequencing><transcriptomic sequencing><transcriptomics><translation research><translational investigation><tuberculosis infection><tuberculous spondyloarthropathy><vaccine against M. tuberculosis><vaccine against Mtb><vaccine against Mycobacterium tuberculosis><vaccine against TB><vaccine against tuberculosis><vaccine candidate><vaccine candidates against tuberculosis><vaccine development>
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Allison Andreno Norful

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$192,028
FY 2025

Project Title

Physiologic Stress and Epigenetic Mechanisms that Precipitate Risk for Suicidal Behavior in Nurses

Grant Number:

5K08MH130652-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/15/2023

End Date:

5/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT The rate of suicide in nurses has reached alarming proportions, with recent estimates upward of 17.1 suicides per 100,000 nurses each year—almost double that of the general population (8.6/100,000). Proposed is a program of training and research using longitudinal design to ...

Research Terms

<Academy><Aeroseb-HC><Age><Alleles><Allelomorphs><Autopsy><Biological><Biological Markers><Blood><Blood Reticuloendothelial System><Blood Sample><Blood Serum><Blood specimen><Cessation of life><Cetacort><Characteristics><Chronic stress><Clinical><Cognitive Discrimination><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Corwin><Cross Sectional Analysis><Cross-Sectional Analyses><Cross-Sectional Studies><Cross-Sectional Survey><DNA Methylation><Data><Data Analyses><Data Analysis><Death><Decision Making><Dermacort><Development><Diathesis><Discipline of Nursing><Discrimination><Disease Frequency Surveys><Disease susceptibility><Diurnal Rhythm><Divorce><Divorced state><Drugs><Economic Income><Economical Income><Eldecort><Environment><Environmental Exposure><Environmental Factor><Environmental Risk Factor><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exposure to><Feeling suicidal><Funding><Gambling><General Population><General Public><Generalized Growth><Genes><Genetic><Genetic Risk><Goals><Grant><Growth><HPA axis><Hair><Health><Health Care><Household><Hydrocortisone><Hydrocortone><Hytone><Income><Individual><Investigation><Iowa><Lateral><Life><Link><Longitudinal Studies><Marital Status><Measurement><Measures><Mediating><Medication><Medicine><Mentors><Mentorship><Methylation><Modeling><Moods><Neurobiology><Nurses><Nursing><Nursing Field><Nursing Profession><Nutracort><Occupational><Patient Self-Report><Pharmaceutical Preparations><Physician Nurse Relationship><Physician-Nurse Relations><Physicians><Physiologic><Physiological><Policies><Precipitating Factors><Predisposing Factor><Preventative intervention><Probabilistic Models><Probability Models><Proctocort><Production><Psychiatric Diagnosis><Psychiatry><Psychologic Interview><Psychological Interview><Psychopathology><Public Health><Reporting><Research><Risk Factors><Saliva><Sample Size><Self-Report><Series><Serum><Sleep><Smoking><Smoking History><Statistical Models><Stress><Stressful Event><Suicidal thoughts><Suicide><Suicide attempt><Suicide precaution><Suicide prevention><Survey Instrument><Surveys><Testing><Time><Tissue Growth><Training><Training Programs><Trauma><United States><Violence><Work Load><Workload><abnormal psychology><ages><analyzing longitudinal><bio-markers><biologic><biologic marker><biological adaptation to stress><biomarker><data interpretation><day shift><developmental><diurnal variation><drug/agent><environmental risk><epigenetically><experience><fatal attempt><fatal suicide><genome scale><genome-wide><genomewide><high risk><high risk group><high risk individual><high risk people><high risk population><hypercortisolemia><hypothalamic-pituitary-adrenal (HPA) axis><hypothalamic-pituitary-adrenal axis><hypothalmus-pituitary-adrenal axis><incomes><instrument><intent to die><intervention for prevention><job environment><liability to disease><life-style factor><lifestyle factors><long-term study><longitudinal analysis><longitudinal design><longitudinal experimental design><longitudinal outcome studies><longitudinal research design><longitudinal study design><loved ones><necropsy><neurobiological><night shift><night work><non fatal attempt><nonfatal attempt><nurse><nursing intervention><ontogeny><pack/year><perceived stress><perception of stress><postmortem><power analysis><prevent suicidality><prevent suicide><prevention intervention><preventional intervention strategy><preventive intervention><professional atmosphere><programs><protective factors><reactioncrisis><recruit><response><self-reported stress><sex><shift work><shiftwork><social cognition><statistical linear mixed models><statistical linear models><stress perception><stress reactivity><stress response><stressreaction><stressful experience><stressful life event><stressful life experience><stressor><study characteristics><substance use><substance using><suicidal attempt><suicidal behavior><suicidal ideation><suicidal individual><suicidal risk><suicidal thinking><suicidality prevention><suicide behavior><suicide ideation><suicide intervention><suicide model><suicide rate><suicide risk><suicides><thoughts about suicide><violent><violent behavior><work atmosphere><work environment><workplace climate><workplace environment>
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Desiree R Hilton

DANA-FARBER CANCER INST, BOSTON, MA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$191,388
FY 2025

Project Title

Integrating pain-CBT into an mHealth analgesic support intervention for patients withchronic pain from advanced cancers

Grant Number:

5K08CA266937-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/17/2024

End Date:

6/30/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Pain affects approximately two thirds of patients with advanced incurable cancers. Cognitive Behavioral Therapy for pain (pain-CBT) is an effective treatment for chronic pain from cancer. Unfortunately, pain-CBT in its traditional format (60-minute, in-person sessions) is of...

Research Terms

<Active Learning><Advanced Cancer><Advanced Malignant Neoplasm><Advisory Committees><Affect><Algorithms><Analgesic Agents><Analgesic Drugs><Analgesic Management><Analgesic Preparation><Analgesics><Android App><Android Application><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Attention><Award><Behavior><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Model><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Behavioral trial><Cancer Intervention><Cancer Patient><Cancer Survivor><Cancer Treatment><Cancers><Cell Phone><Cell Phone Application><Cell phone App><Cellular Phone><Cellular Phone App><Cellular Phone Application><Cellular Telephone><Chronic Cancer Pain><Clinical Trials><Cognition Therapy><Cognitive Psychotherapy><Cognitive Therapy><Cognitive treatment><Complication><Conditioning Therapy><Constipation><Cooperative Learning><Coping Skills><Data><Data Analytics><Dedications><Development><Distress><Doctor of Philosophy><Drug Therapy><Drugs><Ecological momentary assessment><Education><Educational aspects><Emergencies><Emergency Situation><Exercise><Experiential Learning><Fatigue><Feasibility Studies><Funding><Future><Goals><Health Care Technology><Health Technology><Intervention><Intervention Studies><Interview><Investigators><Knowledge><Lack of Energy><Learning><Life><Malignant><Malignant - descriptor><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Measures><Medical><Medication><Medication Management><Mentors><Mentorship><Methods><Mission><Mobile Health App><Mobile Health Application><Mobile Phones><Monitor><Moods><Multimedia><Multimedium><NIH><National Institutes of Health><On-Line Systems><Online Systems><Opiates><Opioid><Pain><Pain Control><Pain Therapy><Pain intensity><Pain interference><Pain management><Painful><Palliative Care><Palliative Therapy><Palliative Treatment><Patients><Persons><Ph.D.><PhD><Pharmaceutical Preparations><Pharmacologic Management><Pharmacological Treatment><Pharmacotherapy><Population><Preparation><Psychological Factors><Psychology><QOL><Quality of life><Randomized><Relaxation><Research><Research Activity><Research Personnel><Researchers><Scientific Advances and Accomplishments><Secondary pain><Sedation procedure><Self Efficacy><Self Management><Self-reflection><Series><Service delivery model><Service model><Severities><Smart Phone App><Smart Phone Application><Smartphone App><Solid><Stress><Structure><Survey Instrument><Surveys><Symptoms><Target Populations><Task Forces><Technology><Testing><Time><Training><Training Programs><Treatment Period><United States National Institutes of Health><Video Recording><Videorecording><Visit><Work><acceptability and feasibility><advisory team><analyzing longitudinal><anti-cancer therapy><app based delivery><app delivery><app on a smartphone><app-delivered><application on a smartphone><behavior intervention><behavioral clinical trial><behavioral intervention><biopsychosocial><cancer pain><cancer therapy><cancer-directed therapy><care as usual><care delivery model><cell phone based app><chronic pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain patient><chronic pain therapy><chronic pain treatment><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><comfort care><coping strategy><curative intervention><curative therapeutic><curative therapy><curative treatments><daily pain><design><designing><develop therapy><developmental><digital care><digital health care><disability><drug intervention><drug treatment><drug/agent><effective therapy><effective treatment><efficacy study><efficacy trial><experience><feasibility testing><health care delivery model><iOS app><iOS application><iPhone><iPhone App><iPhone Application><improved><intervention design><intervention development><intervention refinement><intervention research><interventional research><interventional study><interventions research><longitudinal analysis><m-Health><m-Health app><m-Health application><mHealth><mHealth app><mHealth application><mHealth therapeutic><mHealth therapy><mHealth treatment><malignancy><medication therapy management><mhealth interventions><mobile app><mobile application><mobile application delivered><mobile application delivery><mobile device application><mobile health><mobile health intervention><mobile health therapeutic><mobile health therapy><mobile health treatment><mobile phone app><negative mood><neoplasm/cancer><non-cancer chronic pain><noncancer chronic pain><novel><online computer><opiate consumption><opiate drug use><opiate intake><opiate use><opioid consumption><opioid drug use><opioid intake><opioid use><pain catastrophizing><pain intervention><pain killer><pain medication><pain outcome><pain relief><pain reliever><pain self-management><pain treatment><pain-related outcome><painkiller><palliate><palliative intervention><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><patient with chronic pain><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><phone app><phone application><pilot trial><preparations><programs><psychoeducation><psychologic><psychological><randomisation><randomization><randomized, clinical trials><randomly assigned><recruit><relieve pain><research faculty><retention rate><retention strategy><scientific accomplishments><scientific advances><secondary outcome><sedation><side effect><skills training><smart phone><smartphone><smartphone application><smartphone based app><smartphone based application><telehealth><therapy design><therapy development><treat chronic pain><treatment as usual><treatment days><treatment design><treatment development><treatment duration><trial design><usual care><video recording system><web based>
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Eileen S Hwang

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$190,244
FY 2025

Project Title

Cellular, molecular and physical mechanisms of vitreous structural heterogeneity underlying posterior vitreous detachment

Grant Number:

5K08EY034549-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/30/2023

End Date:

8/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT This is a K08 award application for Dr. Eileen Hwang, a licensed vitreoretinal surgeon, to independently conduct research studies to identify mechanisms of vitreous aging. The K08 will provide her the support necessary to acquire critical skills in four key career developme...

Research Terms

<Abscission><Address><Advisory Committees><Affect><Age><Aging><Animal Model><Animal Models and Related Studies><Area><Award><Biochemistry><Biological><Biological Chemistry><Causality><Cell Body><Cell Culture Techniques><Cells><Cold Therapy><Collagen><Collagen Fiber><Collagen Peptidase><Collagen Type II><Collagen Type IX><Collagen-Degrading Enzyme><Computer Models><Computerized Models><Cryotherapy><Data><Degradation Pathway><Degradative Pathway><Deterioration><Digestion><Domestic Rabbit><Etiology><Excision><Experimental Models><Extirpation><Eye><Eye Movements><Eyeball><Fiber><Future><Gases><Goals><Heterogeneity><Human><Image Analyses><Image Analysis><Imaging Procedures><Imaging Technics><Imaging Techniques><Incidence><Incubated><Individual><International><Intervention><Investigators><Knock-out><Knockout><Knowledge><Leadership><Licensing><Link><Macrophage><Mechanics><Mentors><Methods><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Morbidity><Morbidity - disease rate><Motion><Murine><Mus><Mφ><Oryctolagus cuniculus><Pathway interactions><Posterior Vitreous Detachments><Preventative strategy><Prevention strategy><Preventive strategy><Process><Proteins><QOL><Quality of life><Rabbits><Rabbits Mammals><Removal><Research><Research Personnel><Researchers><Retina><Retinal Detachment><Role><Sight><Specificity><Structure><Surface><Surgeon><Surgical Removal><System><Task Forces><Testing><Therapeutic Cold><Therapeutic Studies><Therapy Research><Translational Research><Translational Science><United States><Vision><Visualization><Work><advisory team><age associated><age associated alterations><age associated changes><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age specific><age specific alterations><age specific changes><aged><ages><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><biologic><career development><causation><cell culture><cell cultures><changes with age><collagenase><computational modeling><computational models><computer based models><computerized modeling><density><disease causation><experiment><experimental research><experimental study><experiments><high risk group><high risk individual><high risk people><high risk population><image evaluation><image interpretation><in vivo confocal microscopy><innovate><innovation><innovative><light scattering><mechanic><mechanical><member><model of animal><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><pathway><prevent><preventing><quantitative imaging><reflectance confocal microscopy><research study><resection><retina detachment><skills><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><translation research><translational investigation><visual function>
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Christopher L Bennett

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$188,500
FY 2025

Project Title

Cost-Effectiveness of HIV Testing in U.S. Emergency Departments

Grant Number:

5K08AI181642-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/19/2024

End Date:

6/30/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY / ABSTRACT Christopher Bennett, MD, MA, MSc K08 AI181642 Cost-Effectiveness of HIV Testing in U.S. Emergency Departments Roughly 1 in 8 Americans living with HIV are unaware of their infection. As an entry point into the healthcare system, emergency departments (EDs) are uniquely po...

Research Terms

<AIDS Virus><AIDS test><AIDS/HIV test><Accident and Emergency department><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><American><Award><Benchmarking><Best Practice Analysis><California><Caring><Charge><Communities><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Crowding><Decision Aid><Emergency Department><Emergency Medicine><Emergency room><Epidemic><Epidemiology><Funding><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Goals><HIV><HIV test><HIV-1 test><HIV-2 test><Health Benefit><Health Care><Health Care Systems><Health Services Evaluation><Health Services Research><Human Immunodeficiency Viruses><Human immunodeficiency virus test><Incidence><Infection><Interview><Investigators><Knowledge><LAV-HTLV-III><Lead><Life Expectancy><Lymphadenopathy-Associated Virus><Medical Care Research><NIH><National Institutes of Health><Patients><Pattern><Pb element><Persons><Physicians><Play><Population><Position><Positioning Attribute><Process><Provider><Public Health><Qualitative Methods><RE-AIM><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Research><Research Personnel><Research Resources><Researchers><Resources><Role><Scientist><Site><Structure><Testing><Training><Typology><United States National Institutes of Health><Universities><Update><Variant><Variation><Virus-HIV><Work><antiretroviral therapy><antiretroviral treatment><assessing cost effectiveness><benchmark><clinical training><cohort><cost><cost effective><cost effectiveness><cost-effectiveness evaluation><cost-effectiveness indices><cost-effectiveness ratio><design><designing><determine cost effectiveness><economic analysis><economic assessment><economic evaluation><epidemiologic><epidemiological><evaluate cost-effectiveness><examine cost effectiveness><geographic site><heavy metal Pb><heavy metal lead><implementation science><implementation strategy><incremental cost-effectiveness><incrementally cost effective><innovate><innovation><innovative><professor><qualitative reasoning><reach, efficacy, adoption, implementation, and maintenance><screening><screening program><screening uptake><screenings><services research><social health determinants><social role><stem><strategies for implementation><structural determinants><structural factors>
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Nikolaos Skartsis

MAYO CLINIC ROCHESTER, ROCHESTER, MN

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$182,520
FY 2025

Project Title

Mechanisms of regulatory T cell adaptation to inflammation

Grant Number:

5K08AI182489-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/3/2024

End Date:

5/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ ABSTRACT This is an application for a K08 award for Dr. Nikolaos Skartsis, an Assistant Professor of Medicine at Mayo Clinic College of Medicine and Science, Rochester, MN. Dr. Skartsis is establishing himself as a young investigator in clinical science research with a translational...

Research Terms

<Address><Agonist><Alloantigen><Animal Model><Animal Models and Related Studies><Anti-Rejection Therapy><Antioxidants><Applications Grants><Autoantigens><Autoimmune Diseases><Autologous Antigens><Autoregulation><Award><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Basal Transcription Factor><Basal transcription factor genes><Basic Research><Basic Science><Binding><Bioinformatics><Biological Agent><Biological Products><Body Tissues><CD 120b Antigen><CD120b Antigens><CD28><CD28 gene><CRISPR><CRISPR approach><CRISPR based approach><CRISPR editing screen><CRISPR method><CRISPR methodology><CRISPR screen><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based screen><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 screen><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Cycle><Cell Cycle Genes><Cell Division Cycle><Cell Division Cycle Genes><Cell Function><Cell Growth in Number><Cell Lineage><Cell Multiplication><Cell Physiology><Cell Process><Cell Proliferation><Cell Signaling><Cell Survival><Cell Therapy><Cell Viability><Cells><Cellular Function><Cellular Metabolic Process><Cellular Physiology><Cellular Process><Cellular Proliferation><Cellular biology><Chromatin Remodeling Complex><Chromatin Remodeling Factor><Clinic><Clinical><Clinical Sciences><Clinical Trials><Clonal Expansion><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Co-Stimulator><Collaborations><Costimulator><Data><Diagnosis><EPH Gestosis><Ensure><Epidermal Thymocyte Activating Factor><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Equilibrium><FOXP3><FOXP3 gene><Forkhead Box P3><Gene Action Regulation><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genes><Genetic Transcription><Goals><Graft Rejection><Grafting Procedure><Grant><Grant Proposals><Growth><HPGF><Hepatocyte-Stimulating Factor><Homeostasis><Human><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-2><IL-6><IL2 Protein><IL6 Protein><Immune><Immune Tolerance><Immune response><Immune system><Immunes><Immunobiology><Immunochemical Immunologic><Immunologic><Immunologic Tolerance><Immunological><Immunologically><Immunologics><Immunophysiology><Immunosuppressants><Immunosuppressive Agents><Immunosuppressive Therapy><Immunosuppressive drug><Immunosuppressive treatment><Immunotherapeutic agent><In Vitro><Inflammation><Inflammatory><Infusion><Infusion procedures><Interleukin 2><Interleukin 2 Precursor><Interleukin II><Interleukin-2><Interleukin-6><Interleukine 2><Interleukine 2 Precursor><Interleukine II><Intracellular Communication and Signaling><Investigators><JM2><Kidney Grafting><Kidney Transplantation><Kidney Transplants><Kinetics><Knowledge><Legal patent><Life><Lymphocyte Mitogenic Factor><MGI-2><Mediating><Medicine><Mentors><Metabolic><Metabolic Control><Mice><Mice Mammals><Mitochondria><Mitogenic Factor><Modality><Modern Man><Molecular><Molecular Interaction><Murine><Mus><Myeloid Differentiation-Inducing Protein><Nucleic Acid Regulator Regions><Nucleic Acid Regulatory Sequences><Organ Transplantation><Organ Transplants><Patents><Pathway interactions><Patients><Phenotype><Physiological Homeostasis><Plasmacytoma Growth Factor><Pre-Clinical Model><Pre-Eclampsia><Preclinical Models><Preeclampsia><Pregnancy Toxemias><Proliferating><Proteinuria-Edema-Hypertension Gestosis><RNA Expression><Receptors, Tumor Necrosis Factor, Type II><Regulatory Regions><Regulatory T-Lymphocyte><Renal Grafting><Renal Transplantation><Renal Transplants><Research><Research Personnel><Researchers><Role><SCURFIN><STAT3><STAT3 gene><Science><Self-Antigens><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell directed therapies><T cell growth factor><T cell immune therapy><T cell immunotherapy><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-Cell Activation><T-Cell Growth Factor><T-Cell Proliferation><T-Cell Stimulating Factor><T-cell therapeutics><T-cell transfer therapy><T44><TNF-R2><TNF-RII><TNFBR><TNFR p75><TNFR2><TNFR80><TNFRSF1B><TNFRSF1B Receptor><TNFRSF1B gene><Techniques><Teff cell><Therapeutic immunosuppression><Thymocyte Stimulating Factor><Tissue Growth><Tissues><Training><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Translational Research><Translational Science><Transplant Rejection><Transplant-Related Disorder><Transplantation><Transplantation Rejection><Treg><Tumor Necrosis Factor Beta Receptor><Tumor Necrosis Factor Receptor 2><Tumor Necrosis Factor Receptor 75><Tumor Necrosis Factor Receptor Type 2><Virginia><Work><activate T cells><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><artificial immunosuppression><autoimmune condition><autoimmune disorder><autoimmunity disease><balance><balance function><biological signal transduction><biologics><biopharmaceutical><biotherapeutic agent><career><cdc Genes><cell based intervention><cell biology><cell mediated intervention><cell mediated therapies><cell metabolism><cell-based therapeutic><cell-based therapy><cellular metabaolism><cellular therapeutic><cellular therapy><chromatin modifier><clustered regularly interspaced short palindromic repeats screen><college><collegiate><cytokine><design><designing><disease model><disorder model><early clinical trial><early phase clinical trial><effector T cell><epigenetically><fitness><functional genomics><genetic regulatory element><healing><host response><immune drugs><immune suppressive agent><immune suppressor><immune system response><immune system tolerance><immune unresponsiveness><immune-based therapeutics><immunologic therapeutics><immunological paralysis><immunoresponse><immunosuppression therapy><immunosuppressive substance><immunosuppressor><immunotherapeutics><immunotherapy agent><improved><in vivo><inflammatory environment><inflammatory milieu><infusions><injury to tissue><innovate><innovation><innovative><interferon beta 2><kidney tx><logarithm><logarithmic><manufacturing process><metabolic fitness><metabolic profile><metabolism measurement><metabolomics><metabonomics><mitochondrial><mitochondrial metabolism><model of animal><multidisciplinary><multiomics><multiple omics><neoplastic><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ontogeny><organ allograft><organ graft><organ xenograft><panomics><pathway><pre-clinical><pre-eclamptic><preclinical><pregnancy toxemia/hypertension><preservation><prevent><preventing><professor><programs><public health relevance><regulatory T-cells><response><safety testing><social role><success><therapeutic T-cell platform><tissue injury><tool><transcription factor><translation research><translational investigation><translational investigator><translational researcher><translational scientist><transplant><transplant disease><transplant therapy><transplant treatment><transplantation therapy><transplantation treatment><tumor necrosis factor receptor superfamily, member 1B>
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SETH BAUER

CLEVELAND CLINIC LERNER COM-CWRU, CLEVELAND, OH

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$177,703
FY 2025

Project Title

Personalized vasopressor therapy in patients with septic shock

Grant Number:

5K08GM147806-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2022

End Date:

8/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Septic shock has a mortality rate above 40%, and is treated with supportive care including vasopressors. Yet, evidence shows vasopressor treatment response and clinician practices are heterogeneous. The key factors mediating this heterogeneity are unknown. This research proj...

Research Terms

<Achievement><Achievement Attainment><Adrenaline><Age><Antidiuretic Hormone><Arteries><Biological><Blood Pressure><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Cessation of life><Characteristics><Circulatory Collapse><Clinic><Clinical><Clinical Investigator Award><Clinical Pharmacists><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Critical Care><Critical Illness><Critically Ill><Data><Data Analytics><Data Science><Data Set><Death><Death Rate><Decision Modeling><Development><Disease><Disorder><Doctor of Philosophy><Drugs><Dysfunction><Electronic Health Record><Environment><Epinephrine><Ethnography><Failure><Functional disorder><Goals><Health><Health system><Heterogeneity><History><Hospitals><Hypotension><Individual><Infection><Inflammatory><Infrastructure><Intensive Care Units><International><Intervention><Interview><K-Awards><K-Series Research Career Programs><K08 Mechanism><K08 Program><Knowledge><LVEF><Leadership><Left Ventricular Ejection Fraction><Levarterenol><Levonorepinephrine><Life><Logistic Regressions><Low Blood Pressure><Machine Learning><Mediating><Medication><Mentorship><Methods><Modeling><Modernization><Noradrenaline><Norepinephrine><Outcome><Output><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Perception><Ph.D.><PhD><Pharmaceutical Preparations><Pharmacodynamics><Pharmacology><Physiopathology><Position><Positioning Attribute><Prediction of Response to Therapy><R-Series Research Projects><R01 Mechanism><R01 Program><Race><Races><Recommendation><Recording of previous events><Regimen><Research><Research Career Program><Research Grants><Research Project Grants><Research Projects><Risk><Role><Scientist><Sepsis><Septic Shock><Shock><Supportive Therapy><Supportive care><Survey Instrument><Surveys><Techniques><Testing><Therapeutic Epinephrine><Training><Translational Research><Translational Science><Translations><Treatment Failure><United States><Vascular Hypotensive Disorder><Vasoactive Agonists><Vasoconstrictor Agents><Vasoconstrictor Drugs><Vasoconstrictors><Vasopressins><Vasopressor Agents><Work><ages><behavior change><beta-Hypophamine><biologic><care delivery><circulatory shock><clinical implementation><clinical practice><clinical predictive model><clinical translation><clinically translatable><co-morbid><co-morbidity><comorbidity><computer based prediction><customized therapy><customized treatment><developmental><dosage><drug/agent><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><ethnographic><histories><implementation framework><implementation research framework><implementation science><implementation science framework><improved><individual patient><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><individuals with sepsis><informatics infrastructure><innovate><innovation><innovative><machine based learning><model development><model developments><mortality><mortality rate><mortality ratio><novel><pathophysiology><patient oriented outcomes><patient response><patient specific response><patient specific therapies><patient specific treatment><patients with sepsis><people with sepsis><predict therapeutic response><predict therapy response><predictive modeling><pressure><racial><racial background><racial origin><response><response to therapy><response to treatment><responsive patient><risk prediction algorithm><risk prediction model><sepsis groups><sepsis patients><sepsis population><sepsis subjects><septic group><septic individuals><septic patients><septic people><septic population><septic subject><sex><shocks><social role><socio-demographics><sociodemographics><stakeholder insights><stakeholder perspectives><subjects with sepsis><tailored medical treatment><tailored therapy><tailored treatment><theories><therapeutic outcome><therapeutic response><therapy failure><therapy outcome><therapy prediction><therapy response><tool><translation><translation research><translational investigation><treatment effect><treatment prediction><treatment response><treatment response prediction><treatment responsiveness><treatment strategy><unique treatment><vasopressor>
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Erika Luz Gustafson

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$177,012
FY 2025

Project Title

Community health worker implementation of a transdiagnostic mental health evidence-based treatment

Grant Number:

5K08MD020100-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/19/2024

End Date:

4/30/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

This K08 proposal will address a critical need for evaluating and understanding the implementation of community health worker (CHW) mental health models to increase evidence-based treatment (EBT) in populations who are less likely to receive mental healthcare. The Common Elements Treatment Approach ...

Research Terms

<0-11 years old><21+ years old><Access to Care><Address><Adult><Adult Human><After Care><After-Treatment><Aftercare><Anxiety><Area><Assess implementation><Attention><Chicago><Child><Child Mental Health><Child Youth><Children (0-21)><Clinic><Clinical><Clinical Trials><Collaborations><Communities><Community Health Aides><Competence><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Country><Data><Data Reporting><Diagnostic><Effectiveness><Elements><Emotional Depression><Environment><Espanol><Ethics><Evaluation><Evidence based treatment><Family><Future><Goals><Health><Health Care Providers><Health Expenditures><Health Personnel><Health Services Accessibility><Home><Hospitals><Household><Implementation assessment><Implementation readiness><Individual><Institution><Interruption><Intervention><Investigators><Investments><Knowledge><Language><Latine><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><Latinx><Lead><Limited English Proficiency><Link><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Measurement><Measures><Mental Depression><Mental Health><Mental Health Services><Mental Hygiene><Mental Hygiene Services><Mental disorders><Mental health disorders><Methods><Modeling><Outcome><Parents><Participant><Patients><Pb element><Population><Position><Positioning Attribute><Prevalence><Procedures><Process><Provider><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Psychopathology><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><Randomization trial><Randomized><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Risk><Savings><Scientist><Service delivery model><Service model><Services><Spanish><Symptoms><System><Training><Translating><Trauma><abnormal psychology><acceptability and feasibility><access differences><access to health care><access to health services><access to services><access to treatment><accessibility of health care><accessibility to health care><accessibility to health services><adulthood><anxious><assess effectiveness><availability of services><care access><care delivery model><career><community advisory board><community advisory committee><community advisory panel><community engagement><community health study><community health worker><compare treatment><data representation><data representations><depression><depression symptom><depressive><depressive symptoms><design><designing><determine effectiveness><differences in access><effectiveness and implementation trial><effectiveness assessment><effectiveness evaluation><effectiveness trial><effectiveness/implementation hybrid trial><effectiveness/implementation trial><engagement with communities><ethical><evaluate effectiveness><evaluate implementation><evaluation of implementation><evidence base><examine effectiveness><experience><global health><health care access><health care availability><health care delivery model><health care expenditure><health care personnel><health care service access><health care service availability><health care worker><health equity><health provider><health service access><health services availability><health training><health workforce><heavy metal Pb><heavy metal lead><homes><implementation determinants><implementation evaluation><implementation factors><implementation framework><implementation intervention><implementation research framework><implementation science><implementation science framework><improved><improved outcome><innovate><innovation><innovative><intergenerational><intervention design><kids><medical expenditure><medical personnel><mental function><mental health care><mental illness><organizational readiness><parent><peer><post treatment><psychiatric illness><psychological disorder><randomisation><randomization><randomized trial><randomly assigned><recruit><safety net><service availability><skill acquisition><skill development><social health determinants><social stigma><stigma><stress symptom><therapy design><traumatic stress><treatment access><treatment comparison><treatment design><treatment provider><youngster>
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Jessica Shiu

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$176,256
FY 2025

Project Title

Determining how local factors influence repigmentation in stable vitiligo

Grant Number:

5K08AR081406-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2023

End Date:

5/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ ABSTRACT: Vitiligo is an autoimmune skin disease characterized by the progressive destruction of melanocytes by autoreactive CD8+ T cells, resulting in disfiguring patches of white depigmented skin that cause significant psychological distress among patients. The gold standard treat...

Research Terms

<Actinotherapy><Affect><After Care><After-Treatment><Aftercare><Area><Autoregulation><Biology><Biopsy><Blood Coagulation Factor III><CD142 Antigens><CD183><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CKR-L2><CMKAR3><CXCL9><CXCL9 gene><CXCR3><CXCR3 gene><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Signaling><Cell model><Cell-to-Cell Interaction><Cells><Cellular Stress><Cellular Stress Response><Cellular biology><Cellular model><Chemokine (C-X-C Motif) Receptor 3><Chemotactic Cytokines><Chronic><Coagulation Factor III><Coagulin><Combined Modality Therapy><Consumption><Cutaneous><Cutaneous imaging><Dermatological Imaging><Dermatology><Development><Disease><Disorder><Doctor of Philosophy><Environment><Equilibrium><Factor III><Funding><G Protein-Coupled Receptor 9><GPR9><Gene Expression><Genomics><Glomerular Procoagulant Activity><Hair Follicle><Hair follicle structure><Homeostasis><Homologous Chemotactic Cytokines><Humig><IP10><IP10 Receptor><IP10-Mig receptor><IP10-R><Image><Immune><Immune response><Immunes><Immunity><Immunosuppressants><Immunosuppressive Agents><Immunosuppressive drug><Immunosuppressive treatment><Inflammation><Injury><Intercrines><Intracellular Communication and Signaling><Investigators><Left><Lesion><Light Therapy><Location><MIG Gene><Maps><Measures><Mentors><Metabolic><Methods><Mig Receptor><Mig-R><MigR><Modeling><Multimodal Therapy><Multimodal Treatment><Patient imaging><Patients><Ph.D.><PhD><Photoradiation Therapy><Phototherapy><Physicians><Physiological Homeostasis><Pigmentation><Pigmentation physiologic function><Pigments><Population><Population Dynamics><Position><Positioning Attribute><Process><Prothrombinase><Publishing><Research><Research Personnel><Research Resources><Researchers><Resistance><Resources><SCYB9><SIS cytokines><Scientist><Shapes><Signal Induction><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Skin Imaging><Steroid Compound><Steroids><Stress><T-Cell Activation><T-Cells><T-Lymphocyte><T8 Cells><T8 Lymphocytes><Technical Expertise><Testing><Thromboplastin><Time><Tissue Factor><Tissue Factor Procoagulant><Tissue Thromboplastin><Training><UVB><UVB radiation><Ultraviolet B><Ultraviolet B Radiation><Urothromboplastin><Vitiligo><WNT Signaling Pathway><WNT signaling><Work><activate T cells><autoimmune cutaneous disease><autoimmune dermatologic disease><autoimmune dermatologic disorder><autoimmune dermatoses><autoimmune reactivity><autoimmune skin condition><autoimmune skin disease><autoimmune skin disorder><autoreactivity><balance><balance function><biological signal transduction><cell biology><cell stress><chemoattractant cytokine><chemokine><combination therapy><combined modality treatment><combined treatment><crg-10><density><design><designing><developmental><experience><host response><imaging><imaging in patients><imaging in vivo><imaging on patients><immune suppressive agent><immune suppressor><immune system response><immunoresponse><immunosuppressive substance><immunosuppressor><in vivo imaging><injuries><insight><keratinocyte><light intervention><light treatment><melanocyte><microscope imaging><microscopic imaging><microscopy imaging><migration><mouse model><multi-modal therapy><multi-modal treatment><multiphoton excitation microscopy><multiphoton microscopy><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><non-invasive imaging><noninvasive imaging><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pigment><pigmentations><post treatment><psychological distress><recruit><resistant><response><response to therapy><response to treatment><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell genomics><single cell transcriptomic profiling><single-cell RNA sequencing><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><standard care><standard treatment><technical skills><therapeutic response><therapy response><thymus derived lymphocyte><tissue wound><treatment response><treatment responsiveness><ultra violet B radiation><wound><wounding><wounds>
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Sima Khakhkhar Ramratnam

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$176,220
FY 2025

Project Title

Interactions Between Genetics, Air Pollution, and Preschool-Onset Childhood Asthma

Grant Number:

1K08HL173691-01A1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/15/2025

End Date:

5/31/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Asthma is the most common chronic disease among children in the United States and is influenced by both genetic and environmental factors. Compared with White children, self-identified Black and Caribbean Hispanic children are up to three times more likely to develop childho...

Research Terms

<0-11 years old><1 year of age><1 year old><21+ years old><5 year old><5 years of age><Achievement><Achievement Attainment><Adult><Adult Human><Affect><Age><Air Pollutants><Air Pollution><Asthma><Asthma in Children><Award><Birth><Black><Black race><Bronchial Asthma><COPD><Candidate Disease Gene><Candidate Gene><Caribbean Hispanic><Cell Body><Cell Death><Cells><Cellular Immune Function><Child><Child Youth><Childhood><Childhood Asthma><Children (0-21)><Chronic Disease><Chronic Illness><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Cilia><Communities><D12S1644><Data><Development><Disparities><Disparity><Enrollment><Environment><Environmental Epidemiology><Environmental Exposure><Environmental Factor><Environmental Risk Factor><Epithelial Cells><Exposure to><GWA study><GWAS><Gene Expression><Gene variant><Gene x Environment Interaction><Generalized Growth><Genes><Genetic><Genetic Diversity><Genetic Polymorphism><Genetic Variation><Genetic predisposing factor><Genomics><Genotype><Geography><Growth><GxE interaction><Heritability><Hospital Admission><Hospitalization><IL-4-STAT><Incidence><Individual><Institutional Racism><International><Latine><Latinx><Life><Link><Lung><Lung Respiratory System><MUC5AC><MUC5AC gene><Mentors><Modeling><Molecular><Molecular Target><Mucins><Mucous body substance><Mucus><Mucus Glycoprotein><NIH><NO2><Nasal><Nasal Epithelium><Nasal Passages Nose><National Institutes of Health><Neighborhoods><Nitrogen Dioxide><Nitrogen Peroxide><Nose><Nursery Schools><O3 exposure><Occluding Junctions><Outcome><PM2.5><Participant><Parturition><Pathway interactions><Pediatric asthma><Pollution><Predisposition><Predisposition gene><Preventative strategy><Prevention strategy><Preventive strategy><Production><Proxy><Race><Races><Research><Research Resources><Resources><Respiratory Epithelium><Respiratory System, Nose, Nasal Passages><Risk><Risk Factors><STAT6><STAT6 gene><STAT6B><STAT6C><School-Age Population><Single Base Polymorphism><Single Nucleotide Polymorphism><Source><Structure of respiratory epithelium><Susceptibility><Susceptibility Gene><Systematic Racism><Systemic Racism><TSLP><TSLP gene><Testing><Thymic Stromal Lymphopoietin><Tight Junctions><Time><Tissue Growth><Training><United States><United States National Institutes of Health><Zonula Occludens><adolescent minority><adulthood><age 1 year><age 5 years><aged 1 year><aged one year><ages><airflow limitation><airflow obstruction><airway epithelium><airway epithelium inflammation><airway inflammation><airway limitation><airway obstruction><allelic variant><asthma prevention><career development><chronic disorder><chronic obstructive pulmonary disorder><cohort><design><designing><developmental><differential expression><differentially expressed><disparity in health><early life exposure><early onset><enroll><environment effect on gene><environmental risk><experience><fine particles><fine particulate matter><five year old><five years of age><gene environment interaction><gene interaction><genetic risk factor><genetic variant><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic variant><health disparity><high risk><immune function><individualized prevention><inherited factor><insight><interest><interleukin-4 Stat><kids><lung function><minority children><minority youth><mucous><necrocytosis><novel><obstructed airflow><obstructed airway><one year of age><one year old><ontogeny><ozone exposure><pathway><pediatric><pediatric minority><personalized prevention><pollutant><polymorphism><pre-k><pre-kindergarten><precision prevention><predisposing gene><preschool><pulmonary function><racial><racial background><racial origin><respiratory airway obstruction><respiratory inflammation><respiratory tract epithelium><respiratory tract inflammation><school age><single nucleotide variant><skills><social><social factors><susceptibility allele><susceptibility locus><susceptibility variant><transcriptional differences><transcriptomics><whole genome association analysis><whole genome association study><young minority><youngster>
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Jason M Nagata

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$174,030
FY 2025

Project Title

Informing national guidelines on adolescent and young adult physical activity and sedentary behavior to prevent cardiovascular disease

Grant Number:

5K08HL159350-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2021

End Date:

7/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY / ABSTRACT Cardiovascular disease (CVD) is the leading cause of death in the United States and physical activity is a potent way to decrease this risk. Serious gaps remain in our understanding of the optimal duration of physical activity and sedentary behavior during adolescence and ...

Research Terms

<12-20 years old><21+ years old><Accounting><Add Health><Adolescence><Adolescent><Adolescent Youth><Adolescent and Young Adult><Adult><Adult Human><Age><American><Apoplexy><Area><Articulation><Behavior><Biometrics><Biometry><Biostatistics><Brain><Brain Nervous System><Brain Vascular Accident><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Cardiac Diseases><Cardiac Disorders><Cardiac infarction><Cardiovascular Diseases><Cause of Death><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cessation of life><Clinical Trials><Coronary Artery Risk Development in Young Adults><Coronary Artery Risk Development in Young Adults Study><Data><Data Science><Death><Department of Health and Human Services><Development><Development Plans><Diabetes Mellitus><Dose><Early Intervention><Encephalon><Epidemiologist><Event><Exposure to><Future><Grant><Growth and Development><Growth and Development function><Guidelines><Health><Health Benefit><Heart Diseases><Human><Hyperlipemia><Hyperlipidemia><Hypertension><Incidence><Intervention><Knowledge><Life><Link><Long-term cohort><Longitudinal Studies><Longitudinal cohort><Measurement><Medicine><Mentors><Mentorship><Methods><Modeling><Modern Man><Modification><Myocardial Infarct><Myocardial Infarction><NHLBI><National Heart, Lung, and Blood Institute><National Longitudinal Study of Adolescent Health><National Longitudinal Survey of Adolescent to Adult Health><Pattern><Physical activity><Physicians><Population><Premature Mortality><Prevention><Public Health><Recommendation><Research Priority><Resource Allocation><Rest><Risk><Risk Factors><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sedentary behavior><Sedentary life-style><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Specific qualifier value><Specified><Strategic vision><Stroke><Testing><Text Messaging><Time><Training><United States><United States Department of Health and Human Services><United States Dept. of Health and Human Services><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Video Games><YouTube><adolescence (12-20)><adult youth><adulthood><age associated><age correlated><age dependent><age group><age linked><age related><age specific><ages><analyzing longitudinal><brain attack><cardiac infarct><cardiovascular disease epidemiology><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder epidemiology><cardiovascular disorder risk><cardiovascular epidemiology><career><career development><cerebral vascular accident><cerebrovascular accident><cognitive development><cohort><conference><convention><coronary attack><coronary infarct><coronary infarction><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><developmental><diabetes><evidence base><experience><heart attack><heart disorder><heart infarct><heart infarction><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><implementation science><juvenile><juvenile human><lack of physical activity><later in life><later life><long-term study><longitudinal analysis><longitudinal outcome studies><markov model><meeting><meetings><mortality><physical inactivity><prevent><preventing><screen time><sedentary><sedentary lifestyle><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><short message service><skills><sms messaging><social media><stroked><strokes><summit><symposia><symposium><television watching><texting><tv watching><video call><video calling><video chat><video phone call><videogame><young adult><young adult age><young adulthood>
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Amy R. Vandiver

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$173,788
FY 2025

Project Title

Understanding mitochondrial mutations that drive human tissue aging

Grant Number:

5K08AG086582-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/12/2024

End Date:

6/30/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT This proposal describes a five-year mentored physician-scientist training program to define the scope and functional consequences of mitochondrial genome mutations in skin tissue aging. The mitochondrial genome (mtDNA) is an extranuclear source of genetic variability that re...

Research Terms

<Address><Advisory Committees><Affect><Age><Aging><Award><Biological><Biology of Aging><Board Certification><Body System><Body Tissues><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Expansion><Cellular Function><Cellular Growth><Cellular Metabolic Process><Cellular Physiology><Cellular Process><Cutaneous><Cutaneous Squamous Cell Carcinoma><DNA mutation><Data><Deletion Mutation><Dermatology><Development><Disparate><Dysfunction><Epidermoid Carcinoma><Epidermoid Skin Carcinoma><Event><Frequencies><Functional disorder><Future><Generalized Growth><Genetic><Genetic Change><Genetic Diversity><Genetic Variation><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Genome><Genomics><Genotype><Growth><Human><In Vitro><Individual><Interdisciplinary Research><Interdisciplinary Study><Intervention><Investigators><Keratinocyte carcinoma><Knowledge><Length><Link><Maps><Mentors><Methods><Mitochondria><Mitochondrial DNA><Modern Man><Morbidity><Morbidity - disease rate><Multidisciplinary Collaboration><Multidisciplinary Research><Mutagenesis><Mutagenesis Molecular Biology><Mutation><Neoplasms><Non-Melanoma Skin Cancer><Nuclear><Organ System><Pattern><Phase><Phenotype><Physicians><Physiopathology><Planocellular Carcinoma><Predisposition><Process><Progenitor Cells><Proliferating><Publishing><Reporting><Research Personnel><Researchers><Role><Sampling><Scientist><Skin><Skin Aging><Skin Carcinoma><Skin Tissue><Source><Specificity><Squamous Carcinoma><Squamous Cell Epithelioma><Squamous cell carcinoma><Stem Cell like><Subcellular Process><Susceptibility><System><Task Forces><Testing><Tissue Growth><Tissue Sample><Tissues><Variant><Variation><Work><advisory team><age associated><age correlated><age dependent><age linked><age related><age specific><aged><aged brain><aged muscle><aged skin><ages><aging brain><aging of muscle><biologic><career><career development><cell growth><cell metabolism><cell type><cellular metabaolism><cutaneous tissue><developmental><effective intervention><experience><face skin><facial skin><genome mutation><genomic variation><hallmarks of aging><heteroplasmy><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human tissue><iPS><iPSC><iPSCs><in vitro Model><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><keratinocyte><keratinocyte progenitor><keratinocyte stem cell><laser capture microdissection><long read seq><long-read sequencing><long-read transcript sequencing><member><mitochondrial><mitochondrial DNA alteration><mitochondrial DNA mutation><mitochondrial genome><mitochondrial metabolism><mortality><mtDNA><mtDNA alteration><mtDNA mutation><muscle aging><mutant><neoplasia><neoplastic growth><nonmelanoma skin cancer><novel><ontogeny><pathophysiology><physician-scientist training program><pillars of aging><prevent><preventing><progenitor aging><progenitor capacity><progenitor cell aging><progenitor cell like><progenitor-like><regeneration biology><regenerative biology><segregation><skills><skin photoaging><skin solar aging><skin squamous cell carcinoma><social role><stem cell aging><stem cell characteristics><stem cells><stem-like><stemness><tumor>
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Bryce Chiang

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$172,584
FY 2025

Project Title

Localization, safety, and efficacy of optic nerve injections

Grant Number:

5K08EY033407-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/30/2022

End Date:

8/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

APPLICATION SUMMARY This is a K08 Mentored Clinician Scientist Research Career Development Award application for Bryce Chiang, MD PhD. Upon completion of ophthalmology residency, Dr. Chiang will be hired as an Assistant Professor of Ophthalmology at the Byers Eye Institute at Stanford. The purpose o...

Research Terms

<Address><Adeno-Associated Viruses><Affect><American><Animal Model><Animal Models and Related Studies><Animals><Attention><Autopsy><Award><Axon><Biology><Body Tissues><CNTF><Caliber><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Catheters><Cell Body><Cells><Ciliary Neuronotrophic Factor><Ciliary Neurotrophic Factor><Clinical><Cranial Nerve II><Cranial Nerve II Diseases><Cranial Nerve II Disorder><Cranial Nerve II Injuries><Cues><Data><Dependoparvovirus><Dependovirus><Disease><Disorder><Doctor of Philosophy><Domestic Rabbit><Doppler OCT><Dose><Dropsy><Drug Delivery><Drug Delivery Systems><Dysfunction><Edema><Electroretinography><Eye><Eyeball><FDA approved><Fellowship><Formulation><Functional disorder><Fundus photography><Glaucoma><Glia><Glial Cells><Growth Agents><Growth Cones><Growth Factor><Growth Substances><Health><Histology><Human><Hydrops><Infusion><Infusion procedures><Injections><Investigators><Ischemia><K-Awards><K-Series Research Career Programs><Kolliker's reticulum><Label><Length><Measures><Mentors><Mentorship><Metabolic><Methods><Modern Man><Natural regeneration><Needles><Nerve Impulse Transmission><Nerve Regeneration><Nerve Transmission><Neural-Optical Lesion><Neuro-regeneration><Neuroglia><Neuroglial Cells><Neuronal Transmission><Neuroregeneration><Non-neuronal cell><Nonneuronal cell><OCT Tomography><Operative Procedures><Operative Surgical Procedures><Ophthalmology><Optic Disk><Optic Nerve><Optic Nerve Diseases><Optic Nerve Head><Optic Nerve Injuries><Optic Nerve Trauma><Optic Neuropathy><Optic Papilla><Optical Coherence Tomography><Optics><Oryctolagus cuniculus><Papillary><Pathogenesis><Pathologist><Pathway interactions><Patients><Pattern><Ph.D.><PhD><Physiologic><Physiological><Physiopathology><Polymers><Prevention><Proteins><Proteins Growth Factors><RNFL><Rabbits><Rabbits Mammals><Radial><Radius><Regeneration><Reporter><Research><Research Career Program><Research Personnel><Researchers><Residencies><Retinal Breaks><Retinal Detachment><Retinal Dialyses><Retinal Ganglion Cells><Retinal Holes><Retinal Perforations><Retinal Tears><Route><Safety><Scientist><Second Cranial Nerve><Second Cranial Nerve Diseases><Second Cranial Nerve Injuries><Second Cranial Nerve Trauma><Sight><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Techniques><Technology><Therapeutic><Time><Tissues><Tracer><Training><Traumatic Optic Neuropathy><Viscosity><Vision><Work><adeno associated virus group><axon damage><axon injury><axon regeneration><axon signaling><axon-glial signaling><axonal damage><axonal injury><axonal regeneration><axonal signaling><central retinal vein occlusion><central retinal vein thrombosis><design><designing><disease model><disorder model><electroretinogram><eye fundus photography><eye toxicity><fundus camera><glaucomatous><glia signaling><glial signaling><improved><improved outcome><in vivo><infusions><injured><macromolecule><macula><macular><model of animal><nano><necropsy><nerve cement><nerve signaling><nervous system regeneration><neural cell body><neural regeneration><neural signaling><neuronal cell body><neuronal signaling><neuroprotection><neuroprotective><neuroregenerative><neurotransmission><non-invasive imaging><noninvasive imaging><novel><ocular toxicity><optic imaging><optic nerve disorder><optical><optical Doppler tomography><optical coherence Doppler tomography><optical imaging><particle><pathophysiology><pathway><polymer><polymeric><postmortem><pre-clinical study><preclinical study><professor><regenerate><regenerated nerve><retina detachment><retinal ganglion><retinal ganglion cell regeneration><retinal nerve fiber layer><retinal toxicity><second cranial nerve disorder><side effect><site targeted delivery><skills><small molecule><soma><spatial and temporal><spatial temporal><spatiotemporal><surgery><targeted delivery><therapeutic candidate><timeline><tonometry><tool><translational therapeutics><translational therapy><visual function>
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Kerry Morrone

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$171,767
FY 2025

Project Title

Reducing Morbidity in Sickle Cell Disease-Prevent Acute Chest Syndrome system (PACSystem) pilot study

Grant Number:

5K08HL173643-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/1/2024

End Date:

5/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT Background: Sickle cell disease (SCD) is chronic hemolytic anemia that causes irreversible organ damage resulting in a shortened lifespan. As a pediatric hematologist, my career goal is to utilize implementation science (IS) and health services research (HSR) methods to address the limitati...

Research Terms

<0-11 years old><AHCPR><AHRQ><ATLEC><Acute pain management><Address><Adherence><Admission><Admission activity><Adoption><Affect><African><Agency for Health Care Policy and Research><Agency for Healthcare Research and Quality><Algorithms><Assess implementation><Atelectasis><Attitude><Award><Behavior><Benchmarking><Best Practice Analysis><Bioinformatics><Bronchial-Dilating Agents><Bronchodilator Agents><Bronchodilators><Caring><Cessation of life><Chest Pain><Child><Child Youth><Childhood><Children (0-21)><Children's Hospital><Chronic><Chronic Disease><Chronic Illness><Clinical><Clinical Decision Support Systems><Clinical Research><Clinical Study><Complication><Computer Simulation><Computer based Simulation><Computer software><Computers><Conduct Clinical Trials><Data><Data Analyses><Data Analysis><Data Collection><Death><Decision Making><Department chair><Development><Disease Management><Disorder Management><Documentation><Education><Educational Achievement><Educational Status><Educational aspects><Effectiveness><Electronic Health Record><Elements><Ensure><Environment><Epidemiology><Ethnic Origin><Ethnicity><Evaluation><Event><Face><Feedback><Funding><Funding Agency><Funding Source><Future><Goals><Guideline Adherence><Guidelines><Hb SS disease><HbSS disease><Health><Health Care Providers><Health Care Systems><Health Personnel><Health Services Evaluation><Health Services Research><Health system><Hematology><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Hemolytic Anemia><Hispanic><Hospital Admission><Hospitalization><Hybrids><Hydration><Hydration status><Hypoventilation><Hypoxemia><Hypoxia><Hypoxic><Image><Implementation assessment><Implementation readiness><Incentives><Individual><Inpatients><Institution><Intervention><Interview><Investigators><K12><K12 Award><K12 Mechanism><K12 Program><Learning><Low income><Lung damage><Maintenance><Manuscripts><Master of Science><Master's Degree><Medical><Medical Care Research><Medicine><Mentored Clinical Scientist Development Program><Mentors><Mentorship><Methods><Modeling><Morbidity><Morbidity - disease rate><Motivation><Multi-center trial><Multicenter Trials><NHLBI><NIH><National Heart, Lung, and Blood Institute><National Institutes of Health><New York><New York City><Nursing Staff><Oncology><Oncology Cancer><Opiates><Opioid><Organ><Outcome><Oxygen Deficiency><Pain><Painful><Participant><Patients><Pediatric Hematologist><Pediatric Hospitals><Pediatric Nursing><Pediatric/Adolescence Nursing><Pediatrics><Perception><Pharmacists><Physicians><Pilot Projects><Population><Preparation><Preventive><Process><Production><Provider><Publications><Qualitative Methods><RE-AIM><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Research><Research Design><Research Methodology><Research Methods><Research Personnel><Research Resources><Researchers><Resources><Respiratory Signs and Symptoms><Respiratory distress><Risk Factors><Scientific Publication><Services><Sickle Cell Anemia><Societies><Software><Spirometry><Standardization><Statistical Methods><Structure><Study Type><Survey Instrument><Surveys><System><Testing><Time><Training><United States><United States Agency for Health Care Policy and Research><United States Agency for Healthcare Research and Quality><United States National Institutes of Health><Work><Youth><Youth 10-21><acute chest syndrome><adherence by clinicians><adherence by providers><airway symptom><barriers to implementation><benchmark><career><child health care provider><chronic disorder><clinician adherence><clinician compliance><cohort><college><collegiate><computational simulation><computerized simulation><conference><convention><data interpretation><design><designing><determine efficacy><developmental><educational level><effectiveness and implementation trial><effectiveness/implementation hybrid study><effectiveness/implementation hybrid trial><effectiveness/implementation study><effectiveness/implementation trial><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><epidemiologic><epidemiological><evaluate efficacy><evaluate implementation><evaluation of implementation><examine efficacy><faces><facial><feasibility testing><health care personnel><health care worker><health provider><health workforce><hypoxemic><imaging><implementation barriers><implementation challenges><implementation evaluation><implementation framework><implementation outcomes><implementation research framework><implementation science><implementation science framework><improved><improved outcome><kids><life span><lifespan><lumen dilator><lung injury><medical personnel><nursing personnel><pediatric><pediatric care provider><pediatric health care provider><pediatric provider><pediatrician><physician adherence><physician compliance><pilot study><preparations><prevent><preventing><primary outcome><provider adherence><provider compliance><pulmonary><pulmonary damage><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><qualitative reasoning><reach, efficacy, adoption, implementation, and maintenance><research and methods><respiratory><respiratory symptom><scale up><secondary outcome><services research><sickle cell disease><sickle cell disorder><sickle disease><sicklemia><skills><software systems><standard of care><statistic methods><statistics><study design><summit><symposia><symposium><tool><training achievement><training level><training status><treatment provider><trial design><uptake><usability><user centered design><youngster><youth age>
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Nathan Richard Blue

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$171,720
FY 2025

Project Title

Individualization of Fetal Growth Assessment using Maternal Genetics and Explainable AI

Grant Number:

5K08HD113835-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/1/2024

End Date:

10/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT This is a K08 award application for Dr. Nathan Blue, a Maternal-Fetal Medicine physician and young inves- tigator pursuing translational and clinical research to improve risk stratification approaches to fetal growth re- striction (FGR). A K08 award will provide him with the means to acqui...

Research Terms

<21+ years old><AI based><AI based method><AI system><AI technology><Address><Adult><Adult Human><Ag element><Apoplexy><Area><Artificial Intelligence><Assessment instrument><Assessment tool><Award><Birth><Birth Weight><Black Box><Brain Vascular Accident><Cardiac Malformation><Cardiac infarction><Caring><Cells Placenta-Tissue><Cerebral Palsy><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cessation of life><Clinical><Clinical Data><Clinical Research><Clinical Study><Complex><Computational Biology><Computational toolkit><Computer Reasoning><Computer Software Tools><Cot Death><Crib Death><Data><Data Science><Death><Dependence><Diagnosis><Discipline of obstetrics><Dysfunction><Family><Fetal Body Weight><Fetal Growth><Fetal Growth Restriction><Fetal Growth Retardation><Fetal Weight><Fetus><Foundations><Functional disorder><Gene variant><Generalized Growth><Genetic><Genetic Risk><Genomics><Gestation><Goals><Growth><Heart Malformation><Height><Human Genetics><IUGR><Infant><Interdisciplinary Research><Interdisciplinary Study><International><Intrauterine Growth Retardation><Investigators><Leadership><Link><Machine Intelligence><Maternal-fetal medicine><Medical><Mentors><Metabolic syndrome><Methodology><Methods><Modeling><Monitor><Morbidity><Morbidity - disease rate><Mothers><Multidisciplinary Collaboration><Multidisciplinary Research><Multiomic Data><Myocardial Infarct><Myocardial Infarction><NICHD><National Institute of Child Health and Human Development><Normal Placentoma><Nulliparas><Nulliparity><Nulliparous><Obstetrics><Outcome><Outcome Study><Output><Parturition><Pediatric cardiology><Perinatal><Perinatal Mortalities><Perinatal lethality><Perinatal mortality demographics><Peripartum><Physicians><Physiopathology><Placenta><Placenta Embryonic Tissue><Placentome><Population><Pregnancy><Pregnancy Outcome><Pregnant Women><Prospective Studies><Prospective cohort><Psychosocial Factor><Publishing><Pythons><Race><Races><Research><Research Personnel><Researchers><Risk><Risk Assessment><Risk Estimate><Risk Factors><SIDS><SNP array><SNP chip><Scientist><Seizures><Silver><Single Base Polymorphism><Single Nucleotide Polymorphism><Software Tools><Stroke><Sudden Infant Death><Sudden Unexpected Infant Death><Sudden infant death syndrome><Techniques><Testing><Tissue Growth><Translational Research><Translational Science><Uncertainty><Visualization><Weight><Woman><abnormal heart development><adulthood><adverse consequence><adverse outcome><allelic variant><artificial intelligence based><artificial intelligence method><artificial intelligence technology><at-risk fetus><authority><biomed informatics><biomedical informatics><brain attack><cardiac infarct><cardiovascular disease risk><cardiovascular disorder risk><career><career development><cerebral vascular accident><cerebrovascular accident><clinical decision support><cohort><computational toolbox><computational tools><computational toolset><computer based prediction><computer biology><computerized tools><congenital cardiac abnormality><congenital cardiac anomalies><congenital cardiac disease><congenital cardiac disorder><congenital cardiac malformation><congenital heart abnormality><congenital heart anomaly><congenital heart disease><congenital heart disorder><congenital heart malformation><coronary attack><coronary infarct><coronary infarction><design><designing><diagnostic approach><diagnostic strategy><doubt><entire genome><expectant mother><expectant women><expecting mother><expecting women><explainable AI><explainable artificial intelligence><fetal><fetal diagnosis><fetus at risk><full genome><genetic information><genetic variant><genome sequencing><genomic data><genomic dataset><genomic variant><global gene expression><global transcription profile><heart attack><heart infarct><heart infarction><impaired fetal growth><improved><individualized predictions><individuals who are pregnant><informatics tool><innovate><innovation><innovative><insight><interpretable AI><interpretable artificial intelligence><intra-uterine growth><intra-uterine growth restriction><intra-uterine growth retardation><intrauterine growth><intrauterine growth restriction><multidisciplinary><multiple omic data><neonatal morbidity><newborn morbidity><novel><obstetrical complication><ontogeny><pathophysiology><people who are pregnant><perinatal complications><perinatal deaths><perinatal morbidity><personalized predictions><population based><postnatal><predictive modeling><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal><prenatal growth disorder><prevent><preventing><psychosocial><psychosocial variables><racial><racial background><racial origin><risk stratification><single nucleotide polymorphism array><single nucleotide polymorphism chip><single nucleotide variant><skill acquisition><skill development><skills><social factors><social health determinants><software toolkit><stillbirth><stillborn><stratify risk><stroked><strokes><synergism><those who are pregnant><time use><tool><transcriptome><translation research><translational investigation><trustworthiness><ultrasound><unborn><weights><whole genome><women who are pregnant>
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Lauren Katz McKay

VIRGINIA COMMONWEALTH UNIVERSITY, RICHMOND, VA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$169,992
FY 2025

Project Title

Myogenic Mechanisms of Craniofacial Skeletal Muscle Regeneration

Grant Number:

7K08DE031029-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2025

End Date:

6/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT This application is for a Mentored Clinical Scientist Research Career Development Award (K08) for Dr. Lauren Katz. She is currently conducting research on craniofacial skeletal muscle and has observed that this muscle type has a unique regenerative program compared to muscles of the limb an...

Research Terms

<Abscission><Affect><Appearance><Assay><Basic Research><Basic Science><Bioassay><Biological Assay><Biology><Birth><Body Tissues><Breathing><Cancers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Body><Cell Function><Cell Isolation><Cell Physiology><Cell Process><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Transplantation><Cells><Cellular Assay><Cellular Function><Cellular Physiology><Cellular Process><Chewing><Clinical><Data><Data Analyses><Data Analysis><Defect><Deglutition><Development><Differential Gene Expression><Discipline><Disease><Disorder><Eating><Environment><Excision><Expression Signature><Extirpation><Extremities><Face><Facial asymmetry><Food Intake><Foundations><Gene Expression Profile><Genes><Genomics><Goals><Hemifacial Microsomia><Impairment><Implant><In Vitro><Individual><Injury><Investigation><K-Awards><K-Series Research Career Programs><Knock-out><Knockout><Knowledge><Lentiviral Vector><Lentivirus Vector><Life><Limb structure><Limbs><Literature><Malignant Neoplasms><Malignant Tumor><Manuscripts><Masseter Muscle><Mastication><Mediating><Mentors><Mentorship><Methodology><Modality><Modeling><Molecular><Molecular Target><Morbidity><Morbidity - disease rate><Muscle><Muscle Disease><Muscle Disorders><Muscle Fibers><Muscle Tissue><Muscle function><Muscle satellite cell><Muscular Diseases><Muscular Dystrophies><Myodystrophica><Myodystrophy><Myopathic Conditions><Myopathic Diseases and Syndromes><Myopathic disease or syndrome><Myopathy><Myotubes><Natural regeneration><Non-Trunk><Oral><Parturition><Patients><Phenotype><Population><Preparation><Progenitor Cell Transplantation><Progenitor Cells><QOL><Quality of life><Regeneration><Regenerative Medicine><Regenerative capacity><Regulation><Removal><Research><Research Career Program><Respiratory Aspiration><Respiratory Inspiration><Rhabdomyocyte><Role><Scientist><Skeletal Fiber><Skeletal Muscle><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Stem Cell Transplantation><Stem cell transplant><Subcellular Process><Surgical Removal><Swallowing><Technology><Testing><Therapeutic><Time><Tissue-Specific Differential Gene Expression><Tissue-Specific Gene Expression><Tissues><Training><Trauma><Viral><Voluntary Muscle><career><cell assay><cell sorting><cellular transplant><chewed><chews><craniofacial><craniofacial disorder><craniofacies><data interpretation><developmental><differential expression><differentially expressed><effective therapy><effective treatment><experiment><experimental research><experimental study><experiments><faces><facial><gene expression pattern><gene expression signature><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><in vivo><in vivo Model><injuries><injury response><inspiration><malignancy><molecular phenotype><multidisciplinary><muscle dystrophy><muscle progenitor><muscle progenitor cell><muscle regeneration><muscle stem cell><muscular><muscular disorder><myogenesis><neoplasm/cancer><new approaches><novel><novel approaches><novel strategies><novel strategy><oral biology><orofacial><preparations><progenitor cell pool><progenitor cell population><progenitor pool><progenitor population><progenitor transplantation><programs><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regeneration ability><regeneration capacity><regeneration potential><regenerative><regenerative potential><resection><response to injury><restoration><satellite cell><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skeletal><skills><social role><stem><stem and progenitor cell population><stem and progenitor cell transplantations><stem cell approach><stem cell based approach><stem cell method><stem cell methodology><stem cell pool><stem cell population><stem cell procedure><stem cell technique><stem cells><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transcriptional differences><transcriptional profile><transcriptional signature><translational therapeutics><translational therapy><tumor>
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Ching-Lan Lu

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$168,296
FY 2025

Project Title

Defining novel neuro-immune pathways that regulate gut physiology

Grant Number:

1K08DK144639-01

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2025

End Date:

5/31/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract This proposal is for a five-year research career development program, focusing on the role of a key enzyme in group 3 innate lymphoid cells (ILC3s) that regulates gut physiology. Inflammatory bowel disease (IBD) is an immune-mediated inflammatory disease of the gastrointesti...

Research Terms

<(TNF)-α><Address><Alimentary Canal><Animal Disease Models><Anti-Tumor Necrosis Factor Therapy><Basic Research><Basic Science><Bioinformatics><Biological Agent><Biological Products><Biopsy><Body Tissues><C rodentium><C. rodentium><Cachectin><Carboxy-Lyases><Catecholamines><Cell Body><Cells><Cellular biology><Chronic><Citrobacter freundii Biotype 4280><Citrobacter rodentium><Clinical Investigator Award><Colon><Communication><DA Neuron><Data><Decarboxylases><Degenerative Neurologic Disorders><Development Plans><Development and Research><Digestive Diseases><Digestive System Diseases><Digestive System Disorders><Digestive Tract><Disease remission><Dopamine><Dopamine neuron><Down-Regulation><Dysfunction><Enteral><Enteric><Enteric Nervous System><Enzyme Gene><Enzymes><Exhibits><Flare><Functional disorder><GI Tract><GI microbiome><GI tract disorder><Gastrointestinal Diseases><Gastrointestinal Motility><Gastrointestinal Tract><Gastrointestinal tract structure><Goals><Human><Hydroxytyramine><Immune><Immune Tolerance><Immune system><Immunes><Immunologic Tolerance><In Vitro><Incidence><Infection><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intestinal><Intestines><Investigation><Investigators><K08 Mechanism><K08 Program><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Knowledge acquisition><L-Dopa><Laboratories><Lead><Levodopa><Link><Lymphatic cell><Lymphocyte><Lymphocytic><Lymphoid Cell><Macrophage-Derived TNF><Mechanics><Mediating><Mentors><Mice><Mice Mammals><Microbe><Modern Man><Monocyte-Derived TNF><Motility><Mucosal Inflammation><Mucositis><Murine><Mus><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neuroimmune><Neurologic><Neurologic Degenerative Conditions><Neurological><Neurons><Neuropeptides><Null Mouse><Operative Procedures><Operative Surgical Procedures><Outcome><Paralysis Agitans><Parkinson><Parkinson Disease><Pathogenesis><Pathway interactions><Patients><Pb element><Physiologic><Physiological><Physiology><Physiopathology><Primary Parkinsonism><Process><Production><Program Development><Psychologic Stress><Psychological Stress><R & D><R&D><RNA Seq><RNA sequencing><RNAseq><Regulation><Relapse><Remission><Research><Research Personnel><Research Proposals><Researchers><Risk><Role><Sampling><Severity of illness><Source><Stimulus><Stress><Surgical><Surgical Interventions><Surgical Procedure><Sympathins><TNF><TNF A><TNF Alpha><TNF gene><TNF therapy><TNF-α><TNFA><TNFα><Testing><Time><Tissues><Training><Transcript><Translational Research><Translational Science><Tumor Necrosis Factor><Tumor Necrosis Factor Therapy><Tumor Necrosis Factor-alpha><alimentary tract><anti-TNF therapy><anti-TNF-alpha therapy><anti-microbial><antimicrobial><biologics><biopharmaceutical><biotherapeutic agent><bowel><bowel inflammation><career><career development><cell biology><cell type><chronic inflammatory disease><clinical investigation><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><digestive canal><digestive disorder><digestive tract disease><digestive tract microbiome><disease control><disease diagnosis><disease severity><disorder control><dopaminergic neuron><dysmotility><dysmotility syndrome><enteral infection><enteric infection><enteric microbiome><enteric pathogen infection><enteropathogen infection><enteropathogenic infection><gastrointestinal disorder><gastrointestinal microbiome><gastrointestinal tract disease><gastrointestinal tract disorder><gut health><gut inflammation><gut microbiome><gut-associated microbiome><heavy metal Pb><heavy metal lead><immune system tolerance><immune unresponsiveness><immunological paralysis><immunoneurology><infected with enteropathogen><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><inhibitor><intestinal autoinflammation><intestinal barrier><intestinal biome><intestinal infection><intestinal inflammation><intestinal microbiome><intestinal mucosal barrier><intestine infection><lymph cell><mechanic><mechanical><monoamine><motility disorder><mouse model><murine model><neurodegenerative illness><neuroimmunology><neuronal><novel><pathophysiology><pathway><patient centered><patient oriented><research and development><response><restraint><skills><small molecule><social role><surgery><therapeutic target><transcriptome sequencing><transcriptomic sequencing><translation research><translational investigation>
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Fotios Spyropoulos

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$168,220
FY 2025

Project Title

Oxidative Stress and Mitochondrial Dysfunction in Chemogenetic Heart Failure

Grant Number:

5K08HL168240-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2023

End Date:

7/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

This K08 Mentored Clinical Scientist Career Development Award describes a five-year research and training program of the principal investigator (PI), Dr. Fotios Spyropoulos, that will enable his transition to independent scientific investigation in the field of oxidative stress-induced cardiac metab...

Research Terms

<21+ years old><Acetylation><Active Oxygen><Acute><Adult><Adult Human><Affect><Alanine><Amino Acids><Animal Model><Animal Models and Related Studies><Animals><Antioxidants><Applied Skills><Assay><Award><Bioassay><Bioenergetics><Biological Assay><Biology><Blood Vessels><Body Tissues><Bypass><Calcium><Cardiac><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular Physiology><Cardiovascular system><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Communication and Signaling><Cell Respiration><Cell Signaling><Cellular Respiration><Chronic><Clinical><Clinical Investigator Award><Coloring Agents><Complex><Complication><D-Amino Acid Dehydrogenase><D-Amino-Acid Oxidase><Data><Deacetylase><Death Rate><Dependence><Development><Disease><Disorder><Dyes><Dysfunction><Environment><Enzyme Gene><Enzymes><Equilibrium><Experimental Models><Fluorescent Probes><Functional disorder><Funding><Future><Generations><Genetic><Goals><H2O2><Heart><Heart Muscle Cells><Heart Vascular><Heart failure><Heart myocyte><Hospitals><Human><Hydrogen Peroxide><Hydroperoxide><IPO-B><Immune Precipitation><Immunoblotting><Immunoprecipitation><Impairment><In Vitro><Indophenol Oxidase B><Injury><Institution><Intracellular Communication and Signaling><Investigation><K-Awards><K-Series Research Career Programs><K08 Mechanism><K08 Program><Knowledge><Laboratories><Lead><Link><MNSOD><Manganese Superoxide Dismutase><Manuscripts><Measures><Mediating><Medical><Membrane Potentials><Mentors><Mentorship><Messenger RNA><Metabolic><Mice><Mice Mammals><Mitochondria><Mitochondrial Superoxide Dismutase><Mn Superoxide Dismutase><Mn-SOD><Modeling><Modern Man><Modification><Molecular><Morbidity><Morbidity - disease rate><Murine><Mus><Myocardium><Neonatal><Organ><Oxidants><Oxidative Stress><Oxidative Stress Induction><Oxidizing Agents><Oxygen Radicals><Pathway interactions><Pattern><Pb element><Persons><Phenotype><Physiology><Physiopathology><Predisposition><Premature Birth><Premature Infant><Prematurely delivering><Preterm Birth><Prevention><Prevention therapy><Principal Investigator><Pro-Oxidants><Protein Acetylation><Proteins><QOL><Quality of life><Reactive Oxygen Species><Recombinants><Regulation><Research><Research Career Program><Research Resources><Resources><Resting Potentials><Role><SOD2><SOD2 gene><Scholarship><Scientist><Senior Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Silent Mating Type Information Regulator 2-like Proteins><Sir2-like Proteins><Sirtuins><Superoxide Anion><Superoxide Dismutase 2><Superoxide Radical><Superoxides><Susceptibility><Testing><Time><Tissues><Training><Training Programs><Transgenic Mice><Transmembrane Potentials><Vascular blood supply><Viral Vector><Virus><Western Blotting><Western Immunoblotting><Woman><Work><Writing><Yeasts><adulthood><aerobic metabolism><aerobic respiration><aminoacid><balance><balance function><biological signal transduction><blood supply><calcium flux><calcium mobilization><cardiac failure><cardiac function><cardiac muscle><cardiomyocyte><cardiovascular function><career development><circulatory system><developmental><dextro-Amino Acid Oxidase><electron acceptor><experience><extracellular><fluorescence imaging><fluorescent imaging><function of the heart><heart function><heart muscle><heavy metal Pb><heavy metal lead><hemodynamics><improved><in vivo><infants born premature><infants born prematurely><injuries><insight><live cell image><live cell imaging><live cellular image><live cellular imaging><mRNA><medical college><medical schools><meeting><meetings><mitochondrial><mitochondrial dysfunction><model of animal><mortality><mortality rate><mortality ratio><mouse model><murine model><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><oxidant stress><oxidation><oxidative metabolism><pathophysiology><pathway><perinatal medicine><premature><premature baby><premature childbirth><premature delivery><premature infant human><prematurity><pressure><preterm baby><preterm delivery><preterm infant><preterm infant human><protein blotting><release of sequestered calcium ion into cytoplasm><response><school of medicine><social role><timeline><vascular><vascular supply>
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Ethan Abbott

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$167,337
FY 2025

Project Title

Addressing Disparities in Out-of-Hospital Cardiac Arrest: Utilization of Health-Related Social Needs and Predictive Analytics to Improve Clinical Outcomes

Grant Number:

5K08HL169980-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2024

End Date:

8/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY The overarching goal of this K08 research project is for Dr. Ethan Abbott, principal investigator (PI), to establish himself as an independent physician-scientist whose research addresses healthcare-related disparities and improves survival for out-of-hospital cardiac arrest (OHCA) ...

Research Terms

<AI language models><Access to Care><Address><Admission><Admission activity><Affect><Algorithms><Area><Black><Black race><Cardiac Catheterization><Cardiac Catheterization Procedures><Caring><Cessation of life><Characteristics><Clinical><Consumption><Data><Data Science><Data Set><Death><Development><Development Plans><Disparities><Disparity><Electronic Health Record><Emergency Medicine><Faculty><Goals><Health><Health Care><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Health Services Accessibility><Health system><Heart Catheterization><Heart Catheterization Procedure><Hospital Admission><Hospital Mortality><Hospitalization><Hospitals><Housing><Implantable Cardioverter-Defibrillators><Implantable Defibrillators><In-house Mortalities><Individual><Information Retrieval><Information extraction><Inhospital Mortality><Insertion of catheter into heart chamber><Intervention><Investigators><Knowledge><Leadership><Manuals><Math Models><Mediation><Medical><Medicare><Mentorship><Methodology><Methods><Modeling><NIH><National Institutes of Health><Natural Language Processing><Negotiating><Negotiation><Neighborhoods><Neurologic outcome><Neurological outcome><Outcome><Patient Care><Patient Care Delivery><Patients><Performance><Persons><Physicians><Position><Positioning Attribute><Predictive Analytics><Principal Investigator><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><Racial Segregation><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Resuscitation><Role><Scientist><Techniques><Temperature><Testing><Time><Title 18><Training><Transformer language model><Transportation><United States><United States National Institutes of Health><Validation><Work><access to health services><access to services><access to transportation><access to treatment><accessibility to health services><artificial intelligence language models><availability of services><beneficiary><care access><care for patients><care of patients><career><career development><caring for patients><clinical care><clinical predictors><cohort><community setting><computer based prediction><determine efficacy><developmental><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><evaluate efficacy><examine efficacy><experience><food insecurity><hazard><health assessment><health equity><health insurance for disabled><health service access><health services availability><housing instability><improved><innovate><innovation><innovative><instably housed><lack of stable housing><large language model><large scale language model><machine learned algorithm><machine learning algorithm><machine learning based algorithm><massive scale language models><mathematic model><mathematical model><mathematical modeling><mortality><multidisciplinary><natural language understanding><novel><out-of-hospital cardiac arrest><out-of-hospital sudden cardiac arrest><predictive modeling><prospective><re-admission risk><readmission risk><residence><residential building><residential site><service availability><skills><social><social role><survival prediction><transportation access><treatment access><unstable housing><unstably housed><validations>
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Lily S Cheng

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$165,456
FY 2025

Project Title

Investigating the role of biomechanical forces on the enteric nervous system in Hirschsprung disease

Grant Number:

5K08DK133673-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/30/2022

End Date:

7/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY As a pediatric surgeon at Texas Children’s Hospital, the nation’s largest children’s hospital and a central hub for the treatment of Hirschsprung’s disease (HSCR)—a disorder caused by defective enteric nervous system (ENS) development, I strive not only to deliver excellent surgical ...

Research Terms

<Abscission><Adhesion Molecule><Adhesion Plaques><Advisory Committees><Affect><Aganglionic Megacolon><Alimentary Canal><Anal Incontinence><Award><Behavior><Biomechanics><Body Tissues><Bowel incontinence><Calcium><Caring><Causality><Cell Adhesion Molecule Gene><Cell Adhesion Molecules><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell-Extracellular Matrix><Cell-Matrix Adherens Junctions><Cells><Characteristics><Childhood><Children's Hospital><Clinical><Clinical Investigator Award><Colon><Colonic Diseases><Congenital Disorders><Congenital Megacolon><Constipation><Data><Deposit><Deposition><Development><Diagnostic><Digestive Tract><Disease><Disorder><Distal><Dysfunction><ECM><Education><Educational aspects><Enteral><Enteric><Enteric Nervous System><Enterocolitis><Etiology><Excision><Extirpation><Extracellular Matrix><Failure><Fecal Incontinence><Focal Adhesion Kinase 1><Focal Adhesions><Focal Contacts><Foundations><Functional disorder><GI Tract><Gastrointestinal Tract><Gastrointestinal tract structure><Generalized Growth><Goals><Growth><Hirschsprung Disease><Human><Hydrogels><Image><In Vitro><Incidence><Infant><Intestinal><Intestinal Diseases><Intestinal Disorder><Intestines><Intracellular Communication and Signaling><Investigation><Ion Channel><Ionic Channels><K08 Mechanism><K08 Program><Laboratories><Logic><Mechanics><Mediator><Membrane Channels><Mentors><Methodology><Modeling><Modern Man><Molecular><Nerve Cells><Nerve Transmitter Substances><Nerve Unit><Nervous System Physiology><Neural Cell><Neurocyte><Neurologic function><Neurological function><Neuronal Dysfunction><Neurons><Neurotransmitters><Operative Procedures><Operative Surgical Procedures><Outcome><PTK2 Protein Tyrosine Kinase 2><Patients><Pediatric Hospitals><Phenotype><Physiopathology><Piezo 1><Piezo 1 ion channel><Piezo1><Postoperative><Postoperative Period><Prevalence><Prognosis><Proliferating><QOL><Quality of life><Radial><Radius><Removal><Research><Role><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Stretching><Structure><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><Task Forces><Technical Expertise><Techniques><Testing><Texas><Tissue Growth><Tissues><Work><advisory team><aganglionosis><alimentary tract><biological signal transduction><biomechanical><biomechanical analyses><biomechanical analysis><biomechanical assessment><biomechanical characterization><biomechanical evaluation><biomechanical measurement><biomechanical profiling><biomechanical test><bowel><career><causation><cell adhesion protein><cell behavior><cellular behavior><clinical relevance><clinically relevant><colon disorder><developmental><digestive canal><disease causation><distraction><endogenous substrate pp120><experiment><experimental research><experimental study><experiments><focal adhesion kinase><focal adhesion protein tyrosine kinase><focal adhesion-associated protein tyrosine kinase pp125FAK><gain of function><gastrointestinal><imaging><improved><in vivo><innovate><innovation><innovative><intestine disease><intestine disorder><loss of function><mechanic><mechanical><mechanical force><nervous system development><nervous system function><neural dysfunction><neuronal><neuronal survival><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><ontogeny><pathophysiology><pediatric><pelvirectal achalasia><postnatal><prognostic tool><resection><response><risk prediction algorithm><risk prediction model><skills><social role><surgery><technical skills><tissue culture><translational impact>
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Deepika Sankaran

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$164,916
FY 2025

Project Title

OPTImal vasoPRESsor in persistent pulmonary hypertension of the newborn (OPTIPRES)

Grant Number:

1K08HL181183-01

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2025

End Date:

7/31/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Perinatal asphyxia is the leading cause of mortality in term newborns globally. Persistent pulmonary hypertension of the newborn (PPHN) is reported in about a quarter of the neonates with perinatal asphyxia is often secondary to meconium aspiration syndrome (MAS) and is a significant...

Research Terms

<0-11 years old><0-4 weeks old><21+ years old><Accounting><Adrenaline><Adrenergic Agents><Adrenergic Drugs><Adrenergics><Adult><Adult Human><Affect><Antidiuretic Hormone><Antidiuretic Hormone Receptor 1A><Arginine Vasopressin Receptor 1A><Arteries><Asphyxia><Asphyxia Neonatorum><BP control><BP management><Biochemical><Biometrics><Biometry><Biostatistics><Blood Pressure><Blood Vessels><Blood flow><Bolus><Bolus Infusion><Cardiac Output><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cessation of life><Child><Child Youth><Children (0-21)><Circulation><Clinical Practice Guideline><Clinical Research><Clinical Study><Clinical Trials><Critical Illness><Critically Ill><Data><Death><Development><Dopamine><Dose><Drugs><EFRAC><Echocardiogram><Echocardiography><Ejection Fraction><Epinephrine><Exposure to><Food and Drug Administration><Future><Goals><Heart Vascular><Hydroxytyramine><Hyperoxia><Hypotension><Hypothermia><Hypoxemia><Immunoblotting><In Vitro><Infant><Knowledge><Leadership><Learning><Left><Left Ventricular Dysfunction><Left Ventricular Function><Levarterenol><Levonorepinephrine><Life><Low Blood Pressure><Measures><Meconium Aspiration><Medication><Muscle><Muscle Tissue><Neonatal><Newborn Infant><Newborns><Noradrenaline><Norepinephrine><Normal saline><O element><O2 element><Organ><Ovine><Ovis><Oxidative Stress><Oxygen><Oxygen Inhalation Therapy><Oxygen Therapy Care><Perfusion><Perinatal><Peripartum><Peripheral Resistance><Persistent Pulmonary Hypertension in Neonates><Persistent Pulmonary Hypertension of Newborn><Pharmaceutical Preparations><Physiologic><Physiological><Placebos><Pulmonary Artery><Pulmonary Circulation><Pulmonary Hypertension><Pulmonary Vascular Resistance><Pulmonary artery structure><Randomization trial><Randomized><Reporting><Research><SCCL Vasopressin Subtype 1a Receptor><SFRAC><Secondary to><Sham Treatment><Sheep><Shortening Fraction><Shunt><Shunt Device><Suffocation><Systemic Vascular Resistance><Systemic blood pressure><Term Birth><Testing><Therapeutic><Therapeutic Epinephrine><Total Peripheral Resistance><Training><Transthoracic Echocardiography><Twin Multiple Birth><Twins><USFDA><United States Food and Drug Administration><V1a vasopressin receptor><Vascular Hypotensive Disorder><Vasoactive Agonists><Vasoconstrictor Agents><Vasoconstrictor Drugs><Vasoconstrictors><Vasodilating Agent><Vasodilator Agents><Vasodilator Drugs><Vasodilators><Vasopressins><Vasopressor Agents><Ventricular><Ventricular Function><Warburg Therapy><Western Blotting><Western Immunoblotting><adulthood><asphyxiation><beta-Hypophamine><birth asphyxia><blood pressure control><blood pressure management><cardiac function><career><circulatory system><clinical development><clinical practice><clinical practice and guidelines><compare to control><comparison control><constriction><continuous monitoring><critically ill newborn><death risk><developmental><drug/agent><empowerment><experience><full-term birth><full-term newborn><function of the heart><heart function><heart output><heart sonography><high risk><hyperoxygenation><hypoxemic><iNO><improved><in vitro testing><inhaled nitric oxide><kids><left ventricle abnormality><lung artery blood pressure><lung vasoconstriction><meconium aspiration syndrome><mortality><mortality risk><muscular><natural hypothermia><neonatal asphyxia><neonatal pulmonary hypertension><neonate><newborn child><newborn children><newborn pulmonary hypertension><newborns with persistent pulmonary hypertension><novel><ovine animal model><ovine model><oxygen administration><oxygen therapy><perinatal asphyxia><persistent pulmonary hypertension><post-natal asphyxia><pressure><pressure in pulmonary arteries><protein blotting><pulmonary><pulmonary arterial blood pressure><pulmonary arterial pressure><pulmonary artery pressure><pulmonary artery systolic pressure><pulmonary hypertension in neonate><pulmonary hypertension in newborn><pulmonary hypertension of neonate><pulmonary vascular constriction><pulmonary vasoconstriction><randomisation><randomization><randomized trial><randomly assigned><receptor expression><response><sham therapy><sheep model><shunts><skill acquisition><skill development><skills><supplemental oxygen><term newborn><trial comparing><vascular><vascular bed><vascular constriction><vasoconstriction><vasopressin type 1A receptor><vasopressor><ventilation><youngster>
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Jeremy Adam Tanner

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$163,080
FY 2025

Project Title

Bridging Gaps to Translate Plasma Alzheimer's Disease Biomarkers to Diverse Populations

Grant Number:

1K08AG090815-01A1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/9/2025

End Date:

7/31/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Plasma biomarkers for Alzheimer’s disease (AD) and related dementias (ADRDs) hold promise as accessible, affordable, and scalable tools for widespread use to support the detection, diagnosis, and care of patients affected by ADRDs. However, critical knowledge gaps remain in ...

Research Terms

<21+ years old><A β-42><A β42><A-beta 42><A-beta42><AD dementia><AD pathology><AD related dementia><ADRD><AIDS Virus><Abeta-42><Abeta42><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Active Follow-up><Address><Adult><Adult Human><Affect><Africa><Africa South of the Sahara><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's and related dementias><Alzheimer's biomarker><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease biological marker><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease pathology><Alzheimer's disease related dementia><Alzheimer's pathology><Alzheimers Dementia><Alzheimer’s biological marker><Alzheimer’s disease biomarker><Amentia><Amyloid beta-42><Amyloid beta42><Amyloid β-42><Amyloid β42><Amyloidβ-42><Amyloidβ42><Area><Astroprotein><Award><Aβ-42><Aβ42><Behavioral><Behavioral Research><Biological><Biological Markers><Biology><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood capillaries><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Classification><Clinical><Cognitive><Cohort Studies><Collaborations><Collection><Competence><Concurrent Studies><Data><Data Analyses><Data Analysis><Degenerative Neurologic Disorders><Dementia><Detection><Diagnosis><Disease><Disorder><Disparities><Disparity><Dryness><Early Diagnosis><Economic Income><Economical Income><Education><Educational aspects><Epidemiology><Fingers><Fostering><Framingham Heart Study><Funding><Future><GFA-Protein><GFAP><General Population><General Public><Generalized Growth><Genetic><Genetic Diseases><Glial Fibrillary Acid Protein><Glial Fibrillary Acidic Protein><Glial Intermediate Filament Protein><Goals><Grant><Growth><HIV><Health><Heart failure><Hepatic Disorder><Human Immunodeficiency Viruses><Income><Individual><Infrastructure><International><Intervention><K-Awards><K-Series Research Career Programs><Kidney Diseases><Knowledge><LAV-HTLV-III><LMIC><Life Style><Lifestyle><Light><Liquid substance><Liver diseases><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Lymphadenopathy-Associated Virus><MR Imaging><MR Tomography><MRI><MRIs><Machine Learning><Magnetic Resonance Imaging><Measures><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mentors><Mentorship><Methods><Multimodal ML><Multimodal machine learning><NMR Imaging><NMR Tomography><Nephropathy><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neuro-epidemiology><Neurodegenerative Diseases><Neurodegenerative Disorders><Neuroepidemiology><Neurologic Degenerative Conditions><Neurologist><Neuronal Injury><Nuclear Magnetic Resonance Imaging><Participant><Patient Care><Patient Care Delivery><Patients><Performance><Persons><Phenotype><Photoradiation><Physicians><Plasma><Plasma Serum><Population><Population Heterogeneity><Precision care><Precision therapeutics><Primary Senile Degenerative Dementia><Public Health><Publications><Renal Disease><Research><Research Career Program><Research Priority><Research Training><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Reticuloendothelial System, Serum, Plasma><Risk><Risk Factors><Risk Reduction><Science><Scientific Publication><Scientist><Spottings><Sub-Saharan Africa><Subsaharan Africa><Systematics><Systemic disease><Testing><Texas><Therapeutic Intervention><Tissue Growth><Training><Translating><Translational Research><Translational Science><Uganda><Universities><Venous><Virus-HIV><Zeugmatography><accurate diagnosis><active followup><adulthood><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age-related disease><age-related disorder><age-related impairment><ages><analyzing longitudinal><behavioral neurology><bio-markers><biologic><biologic marker><biomarker><biomarker identification><biomarker performance><biomarker utility><capillary><cardiac failure><cardiovascular risk><cardiovascular risk factor><care for patients><care of patients><career><caring for patients><clinical training><clinical translation><clinically translatable><co-morbid><co-morbidity><cognitive assessment><cognitive testing><cohort><comorbidity><cost effective><data interpretation><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><dementia burden><dementia risk><diagnostic tool><disease prognosis><disease prognostication><disparity in health><diverse populations><early detection><epidemiologic><epidemiological><fluid><follow up><follow-up><followed up><followup><genetic condition><genetic disorder><health disparity><hepatic disease><hepatopathy><heterogeneous population><high risk><high risk group><high risk individual><high risk people><high risk population><identification of biomarkers><identification of new biomarkers><imaging biomarker><imaging marker><imaging-based biological marker><imaging-based biomarker><imaging-based marker><improved><in vivo><incomes><individualized care><individualized patient care><interest><intervention therapy><kidney disorder><liquid><liver disorder><longitudinal analysis><low and middle-income countries><machine based learning><marker identification><multi-modal data><multi-modal datasets><multi-modality><multimodal data><multimodal datasets><multimodal learning><multimodality><neural inflammation><neurodegenerative illness><neurofilament><neuroinflammation><neuroinflammatory><neuron injury><novel><old age><older adult><older adulthood><ontogeny><p-tau><p-τ><personalized care><personalized health intervention><personalized intervention><personalized patient care><phospho-tau><phospho-τ><phosphorylated tau><population based><population diversity><post-translational modification of tau><posttranslational modification of tau><precision interventions><precision therapies><precision treatment><primary degenerative dementia><primary outcome><professor><prognostic tool><prospective><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><renal disorder><rho><risk factor for dementia><risk for dementia><risk prediction algorithm><risk prediction model><risk stratification><risk-reducing><senile dementia of the Alzheimer type><sex><skills><sleep amount><sleep duration><sleep episode><sleep interval><sleep length><sleep period><sleep quantity><sleep time><social health determinants><statistics><stratify risk><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tau phosphorylation><tau posttranslational modification><tau-1><time asleep><time during sleep><time in sleep><time spent asleep><time spent sleeping><tool><translation research><translational investigation><τ phosphorylation>
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Robert Rosales

BROWN UNIVERSITY, PROVIDENCE, RI

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$163,042
FY 2025

Project Title

Socio-Cultural Protective and Risk Factors of Alcohol Use among Non-Hispanic White and Hispanic Lesbian, Gay, and Bisexual Youth

Grant Number:

5K08MD015289-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/1/2021

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Revised Abstract Section NIAAA identifies underage drinking as a public health issue with serious consequences. Lesbian, gay, and bisexual (LGB) youth who use alcohol have even worse consequences, such as increased risk of cancer, risky sexual behavior, and suicidal attempts. Hispanic LGB youth may...

Research Terms

<ATOD><ATOD use><Address><Affect><Alcohol Chemical Class><Alcohol Drinking><Alcohol abuse><Alcohol consumption><Alcohols><Application Context><Attitude><Automobile collision><Automobile crash><Award><Behavior><Car collision><Car crash><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Coping Skills><Data><Data Analyses><Data Analysis><Development><Ecological momentary assessment><EtOH abuse><EtOH drinking><EtOH use><Ethnic Origin><Ethnicity><Event><Exposure to><Face><Family><Future><Goals><Heterosexuals><Hispanic><Individual><Intervention><K-Awards><K-Series Research Career Programs><LGB><Language><Lesbian Gay Bi-Sexual><Lesbian Gay Bisexual><Literature><Measures><Mediating><Mentors><Mentorship><Methodology><Methods><Motor vehicle collision><Motor vehicle crash><NIAAA><National Institute on Alcohol Abuse and Alcoholism><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Participant><Patient Recruitments><Perception><Persons><Phase><Pilot Projects><Predictive Factor><Public Health><Qualitative Methods><Research><Research Career Program><Risk><Risk Factors><Social support><Source><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Stress><Stress and Coping><Stressful Event><Suicide><Suicide attempt><Testing><Time><Training><Vehicle crash><Vehicular collision><Vehicular crash><Youth><Youth 10-21><Youth Drinking><acceptability and feasibility><adolescent alcohol co-use><adolescent alcohol consumption><adolescent alcohol drinking><adolescent alcohol intake><adolescent alcohol use><adolescent drinking><alcohol co-abuse><alcohol during adolescence><alcohol ingestion><alcohol intake><alcohol intake among adolescents><alcohol poisoning><alcohol problem><alcohol product use><alcohol risk><alcohol tobacco and other drug><alcohol tobacco and other drug use><alcohol tobacco or other drug><alcohol use><alcohol use among adolescents><alcohol use during adolescence><alcohol use in adolescence><alcohol use in adolescents><alcohol, tobacco, or other drug use><alcoholic beverage consumption><alcoholic drink intake><assault><at-risk drinking><binge alcohol consumption><binge drinking><build resilience><build resiliency><cancer risk><career development><cognitive interview><contextual factors><coping><coping strategy><coping with stress><cultural values><data interpretation><develop resilience><develop resiliency><developmental><drinking><drinking during adolescence><drinking in adolescent><drug misuse><enhance resilience><enhance resiliency><episodic drinking><ethanol abuse><ethanol consumption><ethanol drinking><ethanol during adolescence><ethanol ingestion><ethanol intake><ethanol poisoning><ethanol product use><ethanol use><ethnic identity><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><ethyl alcohol poisoning><ethylism><experience><faces><facial><facilitate resilience><fatal attempt><fatal suicide><hazardous alcohol use><high risk><high risk drinking><high risk sex activity><high risk sex behavior><high risk sexual activity><high risk sexual behavior><improve resilience><improve resiliency><increase resilience><increase resiliency><innovate><innovation><innovative><insight><intent to die><medication misuse><negative affect><negative affectivity><non fatal attempt><nonfatal attempt><participant recruitment><perceived stress><perception of stress><pilot study><positive youth development><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><promote resilience><promote resiliency><protective factors><psychological distress><public health relevance><qualitative reasoning><resilience><resilience development><resilience factor><resiliency factor><resilient><response><risky drinking><risky sexual behavior><self-reported stress><social culture><social stress><social stresses><social stressor><social support network><socially stressed><socio-cultural><sociocultural><statistical analysis><stress perception><stress-related coping><stressful experience><stressful life event><stressful life experience><stressor><substance use><substance using><suicidal attempt><suicides><teen drinking><teenage alcohol use><teenage drinking><teenager alcohol use><theories><traffic collision><traffic crash><under age alcohol consumption><under age alcohol use><underage alcohol consumption><underage alcohol use><underage drinking><youth age><youth alcohol co-use><youth alcohol consumption><youth alcohol use>
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Alan Hyun Baik

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$162,946
FY 2025

Project Title

SREBP1 as a Novel Mammalian Oxygen Sensor

Grant Number:

5K08HL169915-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT Millions of people in the United States have cardiopulmonary diseases marked by chronic hypoxia, a persistent reduction in oxygen availability and delivery to cells and tissues. In patients with diseases such as severe chronic obstructive pulmonary disease or advanced heart failure, chronic...

Research Terms

<ADD-1 protein><ADD1 protein><Acute><Affect><Animal Disease Models><Autoregulation><Basal Transcription Factor><Basal transcription factor genes><Binding><Binding Proteins><Binding Sites><Bioinformatics><Biology><Body Tissues><Buffers><C elegans><C. elegans><C.elegans><CAT scan><COPD><CT X Ray><CT Xray><CT imaging><CT scan><Caenorhabditis elegans><Carbon><Cardiovascular Diseases><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Chronic><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Chronic lung disease><Circadian gene expression><Clinical><Combining Site><Communication><Computed Tomography><Consumption><Cor pulmonale><Cyanotic congenital heart disease><Cyanotic heart disease><DNA Binding><DNA Binding Interaction><DNA Molecular Biology><DNA bound><DNA mapping><Data><Development Plans><Diet><Disease><Disorder><Eicosapentaenoic Acid><Exposure to><FTP><Fatty Acids><Fission Yeast><Foundations><Free Fatty Acids><Funding><Gene Transcription><GeneHomolog><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Transcription><Goals><HTH DNA Binding Domain><HTH Motifs><Heart failure><Helix-Turn-Helix Motifs><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><Hexadecanoates><Homeostasis><Homolog><Homologous Gene><Homologue><Hour><Hypoxia><Hypoxia Inducible Factor><Hypoxic><Impairment><Intermediary Metabolism><Intracellular Communication and Signaling><K-Awards><K-Series Research Career Programs><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Laboratories><Leadership><Leucine Zippers><Ligand Binding Protein><Ligand Binding Protein Gene><Lipids><Liver><Liver Cells><Lower Organism><Lung Diseases><Mammalia><Mammalian Cell><Mammals><Measures><Mediating><Mediator><Mentors><Mentorship><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Processes><Metabolism><Mice><Mice Mammals><Mitochondrial Diseases><Mitochondrial Disorders><Molecular><Molecular Biology><Molecular Interaction><Monitor><Morbidity><Morbidity - disease rate><Murine><Mus><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Nonesterified Fatty Acids><Nuclear><Null Mouse><O element><O2 element><Oleates><Organism><Overlapping Genes><Oxygen><Oxygen Deficiency><Palmitates><Pathology><Pathway interactions><Patients><Pattern><Persons><Physicians><Physiological Homeostasis><Polyunsaturated Fatty Acids><Promoter Regions><Promotor Regions><Protein Binding><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Heart Disease><Pulmonary Heart Disorder><Pulmonary Hypertension><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Radiolabeled><Reactive Site><Research><Research Career Program><Research Training><Response Elements><Role><S pombe><S. pombe><SRE-1 binding protein><SREBP-1><SREBP-1c><Saturated Fatty Acids><Schizosaccharomyces pombe><Scientist><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Soy Beans><Soybeans><Sterols><Stress><Structure><Systems Biology><Technical Expertise><Techniques><Testing><Therapeutic><Thesaurismosis><Timnodonic Acid><Tissues><Tomodensitometry><Tracer><Training><Training Programs><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Triacylglycerol><Triglycerides><United States><Unsaturated Fatty Acids><Update><Work><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><Yeasts><biological adaptation to stress><biological signal transduction><bound protein><cardiac failure><cardiopulmonary disease><cardiopulmonary disorder><cardiovascular disorder><career><catscan><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><chronic obstructive pulmonary disorder><chronic pulmonary disease><computed axial tomography><computer tomography><computerized axial tomography><computerized tomography><diets><disease of the lung><disorder of the lung><double bond><eicosapentanoic acid><experiment><experimental research><experimental study><experiments><fat metabolism><formycin 5'-triphosphate><formycin A 5'-triphosphate><formycin triphosphate><functional genomics><gene network><genetic promoter element><genetic promoter sequence><helix loop helix><helix turn helix><hepatic body system><hepatic organ system><lipid metabolism><living system><lung disorder><lung hypoxia><metabolism disorder><microPET/CT><mortality><neurological disease><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><non-contrast CT><noncontrast CT><noncontrast computed tomography><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><oxidation><palm oil><palmolein><pathway><pi bond><programs><promoter sequence><public health relevance><pulmonary hypoxia><radiolabeling><radiologically labeled><reactioncrisis><response><saturated dietary fat><saturated dietary lipid><saturated fat><saturated lipid><sensor><skills><social role><sterol regulatory element binding protein-1c><sterol regulatory element-binding protein 1><stress response><stressreaction><technical skills><transcription factor><transcription factor ADD1><transcriptome sequencing><transcriptomic sequencing><uptake>
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Peggy Ping Hsu

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$162,305
FY 2025

Project Title

Modeling and characterizing early ALK-dependent lung tumorigenesis

Grant Number:

1K08CA286759-01A1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2025

End Date:

7/31/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Lung cancer in never-smokers comprises up to a quarter of lung adenocarcinomas. One of the most frequent subtypes of LCINS is caused by chromosomal rearrangements leading to activation of Anaplastic Lymphoma Kinase (ALK). Early detection of ALK+ cancer is not possible, and it is usua...

Research Terms

<3-D><3-Dimensional><3D><AGTR2><AGTR2 gene><ALK protein><AT2><ATAC><Address><Anaplastic Lymphoma Kinase Ki-1><Atlases><Award><Basal Transcription Factor><Basal transcription factor genes><Body Tissues><Buffers><CD246 Antigen><Cancers><Cell Body><Cell Culture Techniques><Cell Nucleus><Cell Protection><Cells><Chromosomal Rearrangement><Clinical><Communities><Cytoprotection><Data><Data Set><Development><Developmental Biology><Diagnosis><Diagnostic tests><Disease><Disorder><Doctor of Philosophy><EXTMR><Early Diagnosis><Embryo Development><Embryogenesis><Embryonic Development><Engineering><Environment><Epithelium><Event><Evolution><Extramural><Extramural Activities><Foundations><Freezing><Funding><Future><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic><Genetic Transcription><Goals><Heterogeneity><Histologic><Histologically><Human><In Vitro><Institution><Investigation><KO mice><Knock-out Mice><Knockout Mice><LPTN><Laboratories><Lead><Low Molecular Weight Nuclear RNA><Lung><Lung Adenocarcinoma><Lung Neoplasms><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Lung Tumor><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Mentors><Mentorship><Mice><Mice Mammals><Michigan><Modeling><Modern Man><Molecular><Multiomic Data><Murine><Mus><Non-Polyadenylated RNA><Nucleus><Null Mouse><Organoids><Oxidation-Reduction><Patient Care><Patient Care Delivery><Patients><Pb element><Ph.D.><PhD><Physicians><Play><Progenitor Cells><Pulmonary Cancer><Pulmonary Neoplasms><Pulmonary malignant Neoplasm><RNA><RNA Expression><RNA Gene Products><Redox><Research><Research Resources><Resolution><Resources><Rest><Ribonucleic Acid><Role><SCM-1><SCM-1a><SCM1><SCYC1><Sampling><Scientist><Secretory Cell><Small Molecular Weight RNA><Small Nuclear RNA><Smoking History><Stress><Structure of parenchyma of lung><Testing><Time><Tissues><Training><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transplantation><Tumor Cell><Tumor Promotion><Work><XCL1><XCL1 gene><anaplastic lymphoma kinase><anti-cancer research><biobank><biorepository><cancer initiation><cancer research><care for patients><care of patients><career development><caring for patients><cell culture><cell cultures><cell type><cytoprotective><developmental><early detection><experience><heavy metal Pb><heavy metal lead><improved><in vivo><lung cancer><lung tumorigenesis><malignancy><mouse model><multiomics><multiple omic data><multiple omics><murine model><neoplasm/cancer><neoplastic cell><never smoker><new diagnostics><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation diagnostics><novel><novel diagnostics><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><oxidation reduction reaction><pack/year><panomics><pharmacologic><prevent><preventing><progenitor biology><progenitor cell biology><programs><resolutions><selective expression><selectively expressed><single cell analysis><single cell technology><skills><snRNA><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><stem and progenitor biology><stem cell biology><stem cell organoids><stem cell-derived organoids><stem cells><three dimensional><tool><transcription factor><translational oncology><transplant><tumor><tumor initiation><tumorigenesis in the lung><uRNA>
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Katherine Ramos

DUKE UNIVERSITY, DURHAM, NC

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$161,270
FY 2025

Project Title

A Patient-Caregiver Behavioral Intervention for Older Adults with Cancer and Mild Cognitive Impairment

Grant Number:

5K08CA258947-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2022

End Date:

8/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

This proposal presents a five-year research career development program focused on the study and development of a dyadic behavioral intervention to improve distress (e.g., depression and anxiety) and communication for older adults coping with cancer and pre-existing mild cognitive impairment (MCI); a...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Active Follow-up><Address><Adult><Adult Human><Affect><Aged 65 and Over><Anxiety><Area><Award><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Model><Behavioral Modification><Behavioral Sciences><Behavioral Therapy><Behavioral Treatment><Biometrics><Biometry><Biostatistics><Cancer Burden><Cancer Treatment><Cancers><Care Givers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caregivers><Caring><Cell Communication and Signaling><Cell Signaling><Client satisfaction><Cognition Therapy><Cognitive Psychotherapy><Cognitive Therapy><Cognitive deficits><Cognitive treatment><Communication><Communication Programs><Complex><Conditioning Therapy><Coping Skills><Coupled><DCCPS><Data><Data Collection><Development><Diagnosis><Dissemination and Implementation><Distress><Division of Cancer Control and Population Sciences><Educational process of instructing><Elderly><Elements><Emotional Depression><Face><Family><Family Care Giver><Family Caregiver><Feedback><Frequencies><Future><Geriatric Psychiatry><Geriatrics><Goals><Health Care><Health Care Providers><Health Personnel><Health Psychology><Health Services><Impairment><Individual><International><Intervention><Interview><Intracellular Communication and Signaling><Investigators><Judgment><K-Awards><K-Series Research Career Programs><Knowledge><Length><Life><Literature><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Manuals><Measures><Mediation><Medical><Memory><Mental Depression><Mental Health><Mental Hygiene><Mentors><Mentorship><Mission><Modification><NIH><National Cancer Burden><National Institutes of Health><Negotiating><Negotiation><Older Population><Oncology><Oncology Cancer><Outcome><Palliative Care><Palliative Therapy><Palliative Treatment><Participant><Patient Satisfaction><Patients><Personal Satisfaction><Persons><Pilot Projects><Population><Position><Positioning Attribute><Procedures><Program Development><Provider><Psychiatry for older adults><Psychiatry for older people><Psychiatry for seniors><Psychiatry for the elderly><Psychogeriatrics><Psychological Health><Public Health><QOL><Qualitative Research><Quality of life><R-Series Research Projects><R01 Mechanism><R01 Program><Reporting><Research><Research Activity><Research Career Program><Research Grants><Research Methodology><Research Methods><Research Personnel><Research Project Grants><Research Projects><Research Resources><Research Training><Researchers><Resources><Risk><Scientific Advances and Accomplishments><Secure><Self Management><Signal Transduction><Signal Transduction Systems><Signaling><Structure><Symptoms><Teaching><Testing><Thinking><Training><United States National Institutes of Health><Work><above age 65><acceptability and feasibility><active followup><adulthood><advanced age><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><anti-cancer therapy><anxiety symptoms><anxious symptom><arm><behavior intervention><behavioral intervention><biological signal transduction><cancer care><cancer diagnosis><cancer therapy><cancer-directed therapy><career development><chemobrain><chemotherapy-induced cognitive impairment><chemotherapy-related cognitive impairment><clinical practice><co-morbid><co-morbidity><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><cognitive defects><comfort care><comorbidity><coping><coping strategy><depression><depression symptom><depressive><depressive symptoms><design><designing><develop therapy><developmental><evaluation/testing><experience><faces><facial><follow up><follow-up><followed up><followup><formative assessment><formative evaluation><geriatric><geriatric medicine><geriatric psychology><geropsychiatry><geropsychology><geropsychopharmacology><health care personnel><health care worker><health provider><health workforce><human old age (65+)><implementation science><improved><innovate><innovation><innovative><interest><intervention design><intervention development><intervention refinement><loved ones><malignancy><medical personnel><mild cognitive disorder><mild cognitive impairment><neoplasm/cancer><novel><older adult><older adulthood><older groups><older individuals><older person><over 65 years><palliative intervention><participant interview><pilot study><pilot test><post-chemotherapy cognitive impairment><primary outcome><programs><psychological distress><psychological outcomes><psychosocial><recruit><research and methods><satisfaction><scientific accomplishments><scientific advances><secondary outcome><senior citizen><skills><skills training><telehealth><theories><therapy design><therapy development><thoughts><treatment design><treatment development><treatment provider><videoconference><videoconferences><well-being><wellbeing><≥65 years>
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Katharine Simon

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$159,502
FY 2025

Project Title

The role of insufficient sleep and depression on hippocampal-dependent memory trajectories across the adolescent transition

Grant Number:

5K08HD107161-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/7/2022

End Date:

7/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary This K08 proposal will address a critical gap in our fundamental knowledge of the effects of insufficient sleep and depression on longitudinal sleep-dependent memory development and will prepare this applicant, Katharine Simon, PhD, to become an independent translational investigator...

Research Terms

<12 year old><12 years of age><12-20 years old><Address><Adolescence><Adolescent><Adolescent Youth><Affect><Age><Ammon Horn><Attention><Beds><Brain><Brain Nervous System><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Childhood><Circadian Rhythms><Clinical><Clinical Psychology><Clinical assessments><Cognition><Cognitive><Cornu Ammonis><Data><Depressed mood><Development><Disease><Disorder><Doctor of Philosophy><Early Diagnosis><Ecological momentary assessment><Emotional Depression><Encephalon><Equation><Evaluation><Future><Generalized Growth><Goals><Growth><Hippocampus><Individual><Intervention><K-Awards><K-Series Research Career Programs><Knowledge><Measurement><Measures><Mediation><Memory><Memory Deficit><Memory impairment><Mental Depression><Mental Health><Mental Hygiene><Mentors><Methods><Mobile Health App><Mobile Health Application><Modeling><Negotiating><Negotiation><Neurocognitive><Nyctohemeral Rhythm><Outcome><Participant><Pediatric Research><Performance><Ph.D.><PhD><Population><Psychological Health><Psychopathology><Public Health><RDoC><Reporting><Research><Research Career Program><Research Domain Criteria><Risk><Risk Factors><Role><Sampling><Scientist><Single major depression><Single major depressive episode><Sleep><Sleep Architecture><Sleep Deprivation><Symptoms><Testing><Time><Tissue Growth><Training><Twenty-Four Hour Rhythm><United States><Youth><Youth 10-21><abnormal psychology><accelerated aging><accelerated biological age><accelerated biological aging><adolescence (12-20)><adolescent depression><adolescents with depression><age 12 years><age acceleration><ages><career><child depression><childhood depression><childhood onset depression><circadian process><circadian rhythmicity><clinical investigation><cognitive assessment><cognitive neuroscience><cognitive testing><daily biorhythm><deficient sleep><depressed><depressed adolescents><depression><depression in adolescence><depression symptom><depressive><depressive symptoms><design><designing><developmental><diaries><early detection><early onset><fall asleep><hippocampal><inadequate sleep><insufficient sleep><juvenile><juvenile human><longitudinal design><longitudinal experimental design><longitudinal research design><longitudinal study design><m-Health><m-Health app><m-Health application><mHealth><mHealth app><mHealth application><major depressive episode><memory dysfunction><methods to study multiple-level influences><mobile health><multi-level analysis><multi-level model><multilevel analysis><multilevel model><multilevel modeling><novel><old age><ontogeny><pediatric><pediatric depression><poor sleep><pre-adolescent><preadolescence><preteen><prospective><psychologic><psychological><recruit><remote grading><remote review><remote testing><sadness><single episode Major Depression><single episode major depressive disorder><skill acquisition><skill development><sleep amount><sleep debt><sleep deficiency><sleep deficit><sleep duration><sleep episode><sleep insufficiency><sleep interval><sleep length><sleep loss><sleep onset><sleep pattern><sleep period><sleep quantity><sleep routine><sleep schedule><sleep time><sleep/wake patterns><social relationships><social role><spatial memory><time asleep><time during sleep><time in sleep><time spent asleep><time spent sleeping><translational investigator><translational researcher><translational scientist><twelve year old><twelve years of age><verbal><wearable><wearable device><wearable electronics><wearable system><wearable technology><wearable tool><wearables><youth age><youth depression>
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Normarie Torres-Blasco

PONCE SCHOOL OF MEDICINE, PONCE, PR

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$157,491
FY 2025

Project Title

Caregivers-Patients Support to Cope with Advanced-Cancer

Grant Number:

5K08CA279242-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2024

End Date:

7/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

The goal of this K08 is to prepare the PI to receive hands-on experience in implementation and dissemination, as well as design and lead randomized controlled trials (RCTs) in palliative care, and to improve grant writing skills to become an independent R01-funded investigator. The individuals surro...

Research Terms

<Address><Advanced Cancer><Advanced Malignant Neoplasm><American Cancer Society><Anxiety><Area><Assess implementation><Cancer Intervention><Cancer Patient><Cancers><Care Givers><Caregivers><Caring><Catchment Area><Clinical><Clinical Psychology><Communication><Communities><Conflict><Conflict (Psychology)><Data><Diagnosis><Dissemination and Implementation><Distress><Doctor of Philosophy><Family><Feasibility Studies><Fellowship><Fostering><Foundations><Funding><Future><Goals><Grant><Health><Health Sciences><Health care promotion><Implementation assessment><Improve Access><Individual><Institute of Medicine><Institute of Medicine (U.S.)><Intervention><Investigation><Investigators><Language><Lead><Malignant Neoplasms><Malignant Tumor><Mental Depression><Methods><Modeling><NAS/IOM><NCI Organization><National Cancer Institute><Outcome><Palliative Care><Palliative Therapy><Palliative Treatment><Patients><Pb element><Personal Satisfaction><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D.><Ph.D. student><PhD><PhD student><PhD. student><Population><Procedures><Provider><Psychiatric Social Service><Psychiatric Social Work><Psychotherapy><QOL><Quality of life><Randomized, Controlled Trials><Recommendation><Research><Research Institute><Research Personnel><Research Resources><Researchers><Resources><Risk><Series><Services><Source><Spiritual well-being><Spirituality><Training><Underserved Population><Universities><Writing><acceptability and feasibility><alleviate symptom><ameliorating symptom><cancer diagnosis><care outcomes><career development><cohesion><comfort care><community academic collaboration><community academic partnership><community academic research partnership><community based participatory research><community led research><community participatory research><community partnered participatory research><community university partnership><coping><cultural values><culturally adapted intervention><culturally appropriate intervention><culturally centered intervention><culturally focused intervention><culturally informed intervention><culturally responsive intervention><culturally tailored intervention><decrease symptom><depression><design><designing><dissemination science><doctoral student><effectiveness/implementation hybrid study><effectiveness/implementation study><efficacy testing><evaluate implementation><evaluation of implementation><experience><feasibility testing><fewer symptoms><health care outcomes><heavy metal Pb><heavy metal lead><implementation evaluation><implementation research><implementation science><improved><innovate><innovation><innovative><malignancy><member><neoplasm/cancer><palliative intervention><participatory action research><pilot test><pre-doc><pre-doctoral><preference><psychological distress><psychological symptom><psychosocial><psychosocial service><randomized control trial><reduce symptoms><relieves symptoms><response><service gap><skills><skills training><spiritual wellness><symptom alleviation><symptom reduction><symptom relief><telehealth><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people><well-being><wellbeing>
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Glynnis Garry Bann

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$156,600
FY 2025

Project Title

Characterization of PHF7 function in mediating cardiac reprogramming

Grant Number:

5K08HL172012-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2024

End Date:

8/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary The goal of this K08 application is to provide a rigorous 5-year scientific and career development training plan that will facilitate the transition of Dr. Glynnis Garry from a post-doctoral fellow to a fully independent investigator as a cardiovascular physician-scientist. Dr. Garry...

Research Terms

<21+ years old><ATAC><ATAC sequencing><ATAC-seq><ATACseq><Acute><Address><Adult><Adult Human><Advisory Committees><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Award><Basal Transcription Factor><Basal transcription factor genes><Binding><Binding Sites><Bioassay><Biological Assay><Biology><Calcium><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac infarction><Cardiocyte><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Reprogramming><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Chromatin><Chromium><Chronic><Combining Site><Cr element><DNA Molecular Biology><Data><Development><Enhancers><Ensure><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Event><Fellowship><Fibroblasts><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><GATA binding protein 4><GATA4><GATA4 gene><GATA4 transcription factor><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Transcription><Goals><Grant><Health Expenditures><Heart><Heart Diseases><Heart Muscle Cells><Heart Vascular><Heart failure><Heart myocyte><Histologic><Histologically><Histones><Human><Injections><Injury><Institution><Internal Medicine><Investigators><Ischemic Heart><Ischemic Heart Disease><Ischemic myocardium><LPTN><Laboratories><Mating Type Switching/Sucrose Nonfermenting Protein><Mediating><Medical><Mentors><Mentorship><Mice><Mice Mammals><Modality><Modern Man><Modification><Molecular Biology><Molecular Interaction><Morbidity><Morbidity - disease rate><Murine><Mus><Muscle><Muscle Cells><Muscle Tissue><Myocardial Infarct><Myocardial Infarction><Myocardial Ischemia><Myocardium><Myocytes><Natural regeneration><Patients><Physicians><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Productivity><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Reactive Site><Reader><Regeneration><Research><Research Associate><Research Personnel><Research Resources><Researchers><Residencies><Resources><Role><SCM-1><SCM-1a><SCM1><SCYC1><SWI/SNF Complex><SWI/SNF Family Complex><Scientist><Supporting Cell><Task Forces><Technology><Testing><Training><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Treatment Factor><Universities><Work><XCL1><XCL1 gene><adulthood><advisory team><analyze gene expression><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><cardiac failure><cardiac function><cardiac infarct><cardiac ischemia><cardiac muscle><cardiac regeneration><cardiomyocyte><career><career development><cellular reprogramming><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><circulatory system><clinical applicability><clinical application><clinical significance><clinical translation><clinically significant><clinically translatable><cofactor><coronary attack><coronary infarct><coronary infarction><coronary ischemia><determine efficacy><developmental><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><epigenetically><epigenome><epigenomics><evaluate efficacy><examine efficacy><flow cytophotometry><function of the heart><gene expression analysis><gene expression assay><genome scale><genome-wide><genomewide><global gene expression><global transcription profile><health care expenditure><heart attack><heart disorder><heart function><heart infarct><heart infarction><heart ischemia><heart muscle><heart regeneration><immunocytochemistry><improved><in vivo><injuries><injury response><medical expenditure><mortality><multiomics><multiple omics><muscular><myocardial ischemia/hypoxia><myocardium ischemia><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><overexpress><overexpression><panomics><physician-scientist training program><post-doc><post-doctoral><post-doctoral trainee><pre-clinical><preclinical><programs><regenerate><research associates><response to injury><social role><success><transcription factor><transcriptional profiling><transcriptome><transcriptome sequencing><transcriptomic sequencing>
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Christopher Moore Worsham

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$156,276
FY 2025

Project Title

Use of Inter-Hospital Transfer Services in Critical Illness and Acute Respiratory Failure

Grant Number:

5K08HS029197-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

AHRQ

Start Date:

7/1/2023

End Date:

6/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT This K08 award will establish Christopher Worsham, MD, MPH as a clinician-investigator health services researcher examining critical care services and their value using advanced methods of causal inference. Dr. Worsham is an Instructor in Medicine, pulmonologist, and critic...

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Aivi Thanh Nguyen

MAYO CLINIC ROCHESTER, ROCHESTER, MN

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$155,520
FY 2025

Project Title

Role of Microglial Heterogeneity on Cognitive Resilience in Aging and Alzheimer’s Disease

Grant Number:

5K08AG081460-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2024

End Date:

4/30/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT DESCRIPTION/ABSTRACT This NIH K08 proposal describes a five-year career development plan for Dr. Aivi T. Nguyen to obtain the necessary research and professional skills and serve as transition to become a successful, independently funded physician-scientist. Dr. Nguyen completed her clinical...

Research Terms

<2-photon><AD dementia><AD pathology><Address><Aging><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's biomarker><Alzheimer's brain><Alzheimer's disease biological marker><Alzheimer's disease brain><Alzheimer's disease pathology><Alzheimer's pathology><Alzheimers Dementia><Alzheimer’s biological marker><Alzheimer’s disease biomarker><Amyloid><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Anatomic Sites><Anatomic structures><Anatomy><Astroprotein><Autopsy><Award><Aβ><Biological Markers><Blood Plasma><Body Tissues><CNS Diseases><CNS disorder><Central Nervous System Diseases><Central Nervous System Disorders><Cessation of life><Clinic><Clinical Data><Cognition><Cognitive><Cognitive aging><Complex><Data><Death><Deposit><Deposition><Development><Development Plans><Disease Progression><Funding><GFA-Protein><GFAP><Gene Transcription><Genetic><Genetic Risk><Genetic Transcription><Glial Fibrillary Acid Protein><Glial Fibrillary Acidic Protein><Glial Intermediate Filament Protein><Heterogeneity><Histologic><Histologically><Hortega cell><Human><Image><Individual><Infrastructure><Laboratory Research><Ligand Binding><Liquid substance><LysoTracker><MR Imaging><MR Tomography><MRI><MRI biomarker><MRI marker><MRIs><MT-bound tau><Magnetic Resonance Imaging><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Membrane><Mentorship><Mice><Mice Mammals><Microglia><Modern Man><Murine><Mus><NIH><NMR Imaging><NMR Tomography><National Institutes of Health><Nerve Cells><Nerve Unit><Neural Cell><Neuritic Plaques><Neurocyte><Neurofibrillary Tangles><Neuroimmune><Neurons><Neuropsychologies><Neuropsychology><Nuclear Magnetic Resonance Imaging><PET><PET Scan><PET imaging><PETSCAN><PETT><Participant><Pathologic><Pathology><Pennsylvania><Phagocytosis><Phenotype><Physicians><Plasma><Plasma Serum><Play><Population><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Prefrontal Cortex><Primary Senile Degenerative Dementia><RNA Expression><Rad.-PET><Receptor Protein><Reporter><Research><Reticuloendothelial System, Serum, Plasma><Risk-associated variant><Role><Scientist><Senile Plaques><Single-Nucleus Sequencing><Subgroup><TREM2><TREM2 gene><Tauopathies><Testing><Time><Tissues><Transcription><Transgenic Mice><Translational Research><Translational Science><Triggering Receptor Expressed in Myeloid Cells 2><Triggering Receptor Expressed on Myeloid Cells 2><United States National Institutes of Health><Universities><University Hospitals><Visualization><Work><Zeugmatography><a beta peptide><abeta><abeta deposition><abnormally aggregated tau protein><age group><aged><aging associated><aging related><aging resilience><amyloid beta><amyloid beta deposition><amyloid beta plaque><amyloid β deposition><amyloid-b plaque><amyloid-b protein><awake><aβ deposition><aβ plaques><beta amyloid fibril><bio-markers><biologic marker><biomarker><career development><clinical training><coping><cored plaque><demographics><developmental><diffuse plaque><filamentous tau inclusion><fluid><gitter cell><glial activation><glial cell activation><human RNA sequencing><human RNA-seq><human disease><imaging><in vivo><in vivo two-photon imaging><liquid><longitudinal imaging><magnetic resonance imaging biomarker><magnetic resonance imaging marker><meeting><meetings><membrane structure><mesoglia><microglial cell><microgliocyte><microtubule associated protein tau aggregation><microtubule associated protein tau deposit><microtubule bound tau><microtubule-bound tau><mouse model><murine model><natural aging><necropsy><nerve cell death><nerve cell loss><neural imaging><neural inflammation><neuro-imaging><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neuroimaging><neuroimaging biomarker><neuroimaging marker><neuroinflammation><neuroinflammatory><neurological imaging><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal loss><neuropathologic><neuropathologic tau><neuropathological><neuropathological tau><neuropathology><neuroprotection><neuroprotective><neuropsychiatric><neuropsychiatry><neuropsychologic><normal aging><normative aging><p-tau><p-τ><paired helical filament of tau><perivascular glial cell><phospho-tau><phospho-τ><phosphorylated tau><population based><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><post-doctoral training><post-translational modification of tau><postmortem><posttranslational modification of tau><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><primary degenerative dementia><professor><programs><receptor><resilience><resilience during aging><resilience in aging><resilience in normal aging><resilience to aging><resilience with aging><resilient><resilient aging><resilient to aging><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sNuc-Seq><self-aggregate tau><senile dementia of the Alzheimer type><serial imaging><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><skills><snRNA sequencing><snRNA-seq><social role><soluble amyloid precursor protein><spatial and temporal><spatial temporal><spatiotemporal><tangle><tau><tau PHF><tau Proteins><tau accumulation><tau aggregate><tau aggregation><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau fibrillization><tau filament><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neurofibrillary tangle><tau neuropathology><tau oligomer><tau paired helical filament><tau pathology><tau pathophysiology><tau phosphorylation><tau polymerization><tau posttranslational modification><tau proteinopathy><tau related neurodegeneration><tau-1><tau-induced pathology><tau-tau interaction><tauopathic neurodegenerative disorder><tauopathy><translation research><translational investigation><two-photon><τ Proteins><τ aggregation><τ phosphorylation>
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Lauren Nicole Forrest

UNIVERSITY OF OREGON, EUGENE, OR

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$155,265
FY 2025

Project Title

Predicting acute and dynamic suicide risk in rural sexual minorities

Grant Number:

5K08MD019314-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/2/2024

End Date:

5/8/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Sexual minority adults experience suicidal thoughts and behaviors (STBs) at rates 3–6 times higher than heterosexual adults: Up to 20% of sexual minority adults seriously consider suicide each year, compared to 4% of heterosexual adults. Sexual minorities are not a monolithi...

Research Terms

<21+ years old><AIDS/HIV><Access to Care><Active Follow-up><Acute><Address><Adult><Adult Human><Age><Award><Bi-sexual><Birth><Bisexual><Blood Coagulation Factor I><Blood Coagulation Factor One><Blood Factor One><Cause of Death><Cell Phone><Cellular Phone><Cellular Telephone><Clinical><Coagulation Factor I><Coagulation Factor One><Communities><Data><Data Analyses><Data Analysis><Dedications><Disparities><Disparity><Ecological momentary assessment><Enrollment><Environment><Ethnic Origin><Ethnicity><Exclusion><Factor I><Factor One><Feeling suicidal><Fibrinogen><Future><Gays><Gender><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Goals><HIV/AIDS><Health Services Accessibility><Heterosexuals><Hour><Individual><Institution><Internet><Interview><Learning><Lesbian><Medicine><Mental Health><Mental Hygiene><Mentors><Methods><Mobile Phones><Modeling><Participant><Parturition><Pattern><Pennsylvania><Persons><Prevalence><Prevention><Procedures><Process><Protocol><Protocols documentation><Psychological Health><Qualitative Methods><Race><Races><Reporting><Research><Research Resources><Resources><Risk><Risk Behaviors><Risk Factors><Risky Behavior><Rural><Rural Community><Sampling><Scientist><Severities><Sex Orientation><Sexual Orientation><Structure><Subgroup><Suicidal thoughts><Suicide><Suicide precaution><Suicide prevention><Survey Instrument><Surveys><Testing><Training><Training Activity><Universities><WWW><Work><acceptability and feasibility><access to health care><access to health services><access to services><access to treatment><accessibility of health care><accessibility to health care><accessibility to health services><active followup><adulthood><aged><ages><at risk behavior><availability of services><barrier to care><barrier to health care><barrier to treatment><behavior prediction><behavioral prediction><care access><care resources><career><college><collegiate><data interpretation><enroll><experience><fatal attempt><fatal suicide><follow up><follow-up><followed up><followup><gender assigned><gender minority group><gender minority individual><gender minority people><gender minority population><geographic site><health care access><health care availability><health care resources><health care service access><health care service availability><health service access><health services availability><high risk group><high risk individual><high risk people><high risk population><iPhone><innovate><innovation><innovative><intent to die><intersectionalities><intersectionality><minority stress><obstacle to care><obstacle to health care><prevent><prevent suicidality><prevent suicide><preventing><qualitative reasoning><racial><racial background><racial origin><response><rurality><service availability><sex assigned><sexual minority><sexual minority group><sexual minority health><sexual minority health disparity><sexual minority individual><sexual minority people><sexual minority population><skills><smart phone><smartphone><social stigma><stigma><stress among minorities><stress in minorities><stress to minorities><suicidal behavior><suicidal ideation><suicidal risk><suicidal thinking><suicidality prevention><suicide behavior><suicide ideation><suicide intervention><suicide risk><suicides><systematic review><therapeutic target><thoughts about suicide><training module><treatment access><urban area><urban location><urban region><web><world wide web>
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Margaret B Greenwood-Ericksen

UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, ALBUQUERQUE, NM

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$153,706
FY 2025

Project Title

Improving rural mental health equity through Medicaid policy evaluation - resubmission

Grant Number:

5K08HS029038-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

AHRQ

Start Date:

5/1/2023

End Date:

4/30/2028

Why this may be worth a closer look

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Project Abstract

PROJECT SUMMARY/ABSTRACT Candidate: Margaret Greenwood-Ericksen is an early career emergency physician and health services researcher who seeks to transform Medicaid policy to advance rural mental health (MH) equity. Her long-term career goal is to develop an independent program of research evaluati...

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Claire Shappell

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$153,360
FY 2025

Project Title

Antibiotic Utilization Patterns and Impact on Outcomes for Patients with Respiratory Viral Sepsis

Grant Number:

5K08HS029518-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

AHRQ

Start Date:

9/1/2023

End Date:

8/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Although there is increasing recognition that viruses are an important cause of sepsis, most clinicians and policymakers tend to equate sepsis with bacterial infection. As a result, current guidelines emphasize immediate administration of antibiotics for all patients with suspected sepsis, even thou...

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Carl Thomas Berdahl

CEDARS-SINAI MEDICAL CENTER, LOS ANGELES, CA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$150,921
FY 2025

Project Title

Detecting and characterizing diagnostic errors among high-risk patients discharged from the emergency department

Grant Number:

5K08HS029534-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

AHRQ

Start Date:

5/1/2024

End Date:

4/30/2029

Why this may be worth a closer look

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Project Abstract

Project Summary In the U.S., emergency departments (EDs) care for >130 million patients each year. Current estimates suggest that 5% of all ED patients experience a diagnostic error, leading to harm for 2.5 million ED patients and death or permanent disability for 350,000 each year. The vast majori...

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Cristina De Mattos Pimenta Vidal

UNIVERSITY OF IOWA, IOWA CITY, IA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$144,990
FY 2025

Project Title

Modulation of MMPs gene expression and activity by the microbiome in caries

Grant Number:

5K08DE029490-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/1/2021

End Date:

6/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Caries is a multifactorial disease that results from an imbalance between the microbiome and the host leading to demineralization of the dental hard tissues. After a lesion initiates in enamel, further tissue demineralization will lead to cavitation and involvement of the de...

Research Terms

<21+ years old><Abscission><Adult><Adult Dentition><Adult Human><Age><Award><Bacteria><Binding><Biochemical><Bioinformatics><Biology><Body Tissues><Caries><Causality><Cell Body><Cell-Extracellular Matrix><Cells><Clinical><Collagen Peptidase><Collagen-Degrading Enzyme><Communication><Complex><Data><Dental><Dental Decay><Dental Enamel><Dental caries><Dentin><Dentin Formation><Dentistry><Development><Diet><Disease><Disease Progression><Disorder><ECM><Enamel><Endopeptidase-Activated Receptors><Ensure><Environment><Enzyme Activation><Enzyme Gene><Enzymes><Esteroproteases><Esthetics><Etiology><Excision><Extirpation><Extracellular Matrix><Filtration><Filtration Fractionation><Foundations><Future><Gene Expression><Genetic><Genomics><Goals><Health><Immune response><In Vitro><Infiltration><Interdisciplinary Research><Interdisciplinary Study><Investigators><Knowledge><Leadership><Left><Lesion><Maps><Mediating><Mentors><Mentorship><Metallopeptidases><Metalloproteases><Metalloproteinases><Methodological Studies><Microbiology><Minerals><Modeling><Molecular Interaction><Mouth microbiome><Multidisciplinary Collaboration><Multidisciplinary Research><NHANES><National Health and Nutrition Examination Survey><Odontoblasts><Operative Procedures><Operative Surgical Procedures><Oral><Pathology><Pattern recognition receptor><Peptidases><Peptide Hydrolases><Permanent Dentition><Population><Process><Property><Protease Gene><Protease-Activated Receptors><Proteases><Proteinase-Activated Receptors><Proteinases><Proteins><Proteolytic Enzymes><Proteomics><Publications><Removal><Research><Research Personnel><Research Resources><Research Support><Researchers><Resources><Role><Salivary><Scientific Publication><Scientist><Secondary Dentition><Structure><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><Testing><Time><Tissues><Tooth><Tooth Loss><Tooth structure><Training><Undifferentiated><United States><Writing><adult youth><adulthood><ages><career development><cariogenic bacteria><causation><collagenase><cost><demineralization><dental pulp progenitor><dental pulp stem cells><dental pulp stem/progenitor cells><design><designing><developmental><dietary><diets><disease causation><effective therapy><effective treatment><experience><experiment><experimental research><experimental study><experiments><host microbiome><host response><immune system response><immunoresponse><in vivo><innovate><innovation><innovative><insight><member><microbial composition><microbiome><microorganism><mineralization><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><oral microbiome><permanent tooth><prevent><preventing><protein expression><pulp stem cells><remineralization><repair><repaired><reparative process><resection><restoration><screening><screenings><skills><social role><sound><surgery><teeth><tissue repair><tooth decay><tooth enamel><young adult><young adult age><young adulthood>
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Heidi Herrick

CHILDREN'S HOSP OF PHILADELPHIA, PHILADELPHIA, PA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$143,243
FY 2025

Project Title

Leveraging Human Factors to Evaluate Quality of Neonatal Delivery Room Care

Grant Number:

5K08HS029029-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

AHRQ

Start Date:

6/3/2022

End Date:

5/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT The purpose of this Mentored Clinical Scientist Research Career Development Award (K08) is to prepare Heidi M. Herrick, MD MSCE, Clinical Instructor and Attending Physician at the Children’s Hospital of Philadelphia and the Hospital of the University of Pennsylvania for her...

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Aram Sandaldjian Modrek

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$142,007
FY 2025

Project Title

Epigenetic alterations after DNA damage repair drive treatment resistance in glioblastoma

Grant Number:

5K08CA263302-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/20/2022

End Date:

8/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT In this K08 career development award, the principal investigator (PI) aims to determine how DNA-methylation is altered after DNA damage and investigate the impact of these changes on 3D chromatin organization, gene regulation and treatment resistance. The PI studies this pro...

Research Terms

<3-D><3-Dimensional><3C-based approach><3C-based assay><3C-based method><3C-based strategy><3C-based technique><3C-based technology><3D><Address><Basal Transcription Factor><Basal transcription factor genes><Binding><Biologic Models><Biological Models><Brain Cancer><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancer Genes><Cancer Treatment><Cancer-Promoting Gene><Cancers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cas nuclease technology><Cell Body><Cell Culture Techniques><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Chemotherapy and Radiation><Chemotherapy and/or radiation><Chromatin><Chromosome Mapping><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Comet Assay><DNA><DNA Damage><DNA Damage Repair><DNA Injury><DNA Methylation><DNA Methyltransferase><DNA Modification Methylases><DNA Modification Methyltransferases><DNA Repair><DNA mapping><DNA seq><DNA sequencing><DNA-Binding Proteins><DNA-Methyltransferases><DNAseq><Data><Deoxyribonucleic Acid><Dnmt><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Faculty><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene Regulation><Gene Regulation Process><General Transcription Factor Gene><General Transcription Factors><Genome><Glioblastoma><Goals><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><Guide RNA><HMG 2><HMG 2 Protein><HMG-2 Gene><HMG2><HMG2 Gene><HMGB2><HMGB2 Protein><HMGB2 gene><High Mobility Group Box Protein 2><High Mobility Group Protein 2><High Mobility Group Protein 2 Gene><High-Mobility Group (Nonhistone Chromosomal) Protein 2><High-Mobility Group (Nonhistone Chromosomal) Protein 2 Gene><High-Mobility Group Box 2><High-Mobility Group Box 2 Gene><Human><Individual><Investigators><K-Awards><K-Series Research Career Programs><Knowledge><Lead><Life><Linkage Mapping><Malignant Cell><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Brain><Malignant neoplasm of brain><Measures><Mediating><Mentors><Mission><Model System><Modeling><Modern Man><Modification Methylases><Molecular Analysis><Molecular Interaction><NIH><National Institutes of Health><Nonhistone Chromosomal Protein HMG2><Nonhistone Chromosomal Protein HMG2 Gene><Oncogenes><Patients><Pb element><Phase><Population><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Principal Investigator><Process><Protein Modification><Public Health><RNA Seq><RNA sequencing><RNAseq><Radiation><Radiation Induced DNA Damage><Radiation Induced Genotoxicity><Radiation Sensitizers><Radiation induced damage><Radiation therapy><Radiation-Induced Change><Radiation-Sensitizing Agents><Radiation-Sensitizing Drugs><Radiosensitization><Radiosensitizing Agents><Radiosensitizing Drugs><Radiotherapeutics><Radiotherapy><Radiotherapy sensitizer><Recurrent Neoplasm><Recurrent tumor><Regulatory Element><Reproducibility><Research><Research Career Program><Research Personnel><Researchers><Resolution><Role><Single-Cell Gel Electrophoresis><Site><Site-Specific DNA-methyltransferase><Stress><Structure><System><Testing><Therapeutic><Total Human and Non-Human Gene Mapping><Training><Transcription Factor Proto-Oncogene><Transcription factor genes><Transforming Genes><United States National Institutes of Health><Unscheduled DNA Synthesis><anti-cancer therapy><cancer cell><cancer therapy><cancer-directed therapy><career><career development><cell culture><cell cultures><chemo-/radio-sensitization><chemo/radiation therapy><chemotherapy and radiotherapy><chromatin conformation capture><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><chromosome capture><chromosome conformation capture><cohesin><demethylation><endonuclease><epigenetically><epigenome><experiment><experimental research><experimental study><experiments><gRNA><genetic mapping><genome scale><genome-wide><genomewide><glioblastoma multiforme><heavy metal Pb><heavy metal lead><histone modification><in vivo><inhibitor><innovate><innovation><innovative><insight><malignancy><meeting><meetings><neoplasm recurrence><neoplasm/cancer><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><radiation damage><radiation damage to DNA><radiation or chemotherapy><radiation sensitization><radiation treatment><radiation-induced DNA breaks><radio-/chemo-sensitization><radio-sensitization><radiosensitizer><radiotherapy sensitization><recruit><repair><repaired><resistance to therapy><resistant to therapy><resolutions><response><skill acquisition><skill development><small molecular inhibitor><small molecule inhibitor><social role><spatial and temporal><spatial temporal><spatiotemporal><spongioblastoma multiforme><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic resistance><therapeutic target><therapy resistant><three dimensional><time use><tool><transcription factor><transcriptome sequencing><transcriptomic sequencing><treatment effect><treatment resistance><treatment with radiation><tumor><tumor growth>
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Christopher L Bennett

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$73,340
FY 2025

Project Title

Cost-Effectiveness of HIV Testing in U.S. Emergency Departments

Grant Number:

3K08AI181642-02S1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/19/2024

End Date:

6/30/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY / ABSTRACT Christopher Bennett, MD, MA, MSc K08 AI181642 Cost-Effectiveness of HIV Testing in U.S. Emergency Departments Roughly 1 in 8 Americans living with HIV are unaware of their infection. As an entry point into the healthcare system, emergency departments (EDs) are uniquely po...

Research Terms

<AIDS Virus><AIDS test><AIDS/HIV test><Accident and Emergency department><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><American><Award><Benchmarking><Best Practice Analysis><California><Caring><Charge><Communities><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Crowding><Decision Aid><Emergency Department><Emergency Medicine><Emergency room><Epidemic><Epidemiology><Funding><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Goals><HIV><HIV test><HIV-1 test><HIV-2 test><Health Benefit><Health Care><Health Care Systems><Health Services Evaluation><Health Services Research><Human Immunodeficiency Viruses><Human immunodeficiency virus test><Incidence><Infection><Interview><Investigators><Knowledge><LAV-HTLV-III><Lead><Life Expectancy><Lymphadenopathy-Associated Virus><Medical Care Research><NIH><National Institutes of Health><Patients><Pattern><Pb element><Persons><Physicians><Play><Population><Position><Positioning Attribute><Process><Provider><Public Health><Qualitative Methods><RE-AIM><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Research><Research Personnel><Research Resources><Researchers><Resources><Role><Scientist><Site><Structure><Testing><Training><Typology><United States National Institutes of Health><Universities><Update><Variant><Variation><Virus-HIV><Work><antiretroviral therapy><antiretroviral treatment><assessing cost effectiveness><benchmark><clinical training><cohort><cost><cost effective><cost effectiveness><cost-effectiveness evaluation><cost-effectiveness indices><cost-effectiveness ratio><design><designing><determine cost effectiveness><economic analysis><economic assessment><economic evaluation><epidemiologic><epidemiological><evaluate cost-effectiveness><examine cost effectiveness><geographic site><heavy metal Pb><heavy metal lead><implementation science><implementation strategy><incremental cost-effectiveness><incrementally cost effective><innovate><innovation><innovative><professor><qualitative reasoning><reach, efficacy, adoption, implementation, and maintenance><screening><screening program><screening uptake><screenings><services research><social health determinants><social role><stem><strategies for implementation><structural determinants><structural factors>
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Ana Cristancho

CHILDREN'S HOSP OF PHILADELPHIA, PHILADELPHIA, PA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$54,000
FY 2025

Project Title

Admin Supplement for K08

Grant Number:

3K08NS119797-04S1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2022

End Date:

8/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Neonatal hypoxic ischemic encephalopathy (HIE), a common brain injury from loss of oxygen and nutrients immediately prior to birth, results in long-term neurologic deficits even in the absence of significant perinatal cell death. A major gap in the perinatal injury field is the limi...

Research Terms

<0-11 years old><21+ years old><ATAC sequencing><ATAC-seq><ATACseq><Acquired brain injury><Adult><Adult Human><Animals><Assay for Transposase-Accessible Chromatin using sequencing><Behavior><Behavioral><Bioinformatics><Birth><Brain><Brain Injuries><Brain Nervous System><Cell Death><Cell Nucleus><Child><Child Youth><Children (0-21)><Clinical Skills><DNA Molecular Biology><Data><Dendritic Spines><Development><Electroporation><Encephalon><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exposure to><Funding><Gene Action Regulation><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Genes><Gestation><Goals><Histones><Hour><Hypoxia><Hypoxic><Injury><KO mice><Knock-out Mice><Knockout Mice><Link><Low Molecular Weight Nuclear RNA><Mentors><Mice><Mice Mammals><Modeling><Molecular Biology><Murine><Mus><Neocortex><Neonatal asphyxia-induced brain injury><Neonatal hypoxic brain injury><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic Deficit><Neurologic Disorders><Neurological Disorders><Neurologist><Neuronal Injury><Neurons><Non-Polyadenylated RNA><Nucleus><Null Mouse><Nutrient><O element><O2 element><Outcome><Oxygen><Oxygen Deficiency><Parturition><Pathology><Perinatal><Perinatal Brain Injury><Perinatal brain damage><Peripartum><Phenocopy><Physicians><Pregnancy><RNA><RNA Gene Products><Research><Ribonucleic Acid><Scientist><Small Molecular Weight RNA><Small Nuclear RNA><Spinal Column><Spine><Testing><Translational Research><Translational Science><Upregulation><Variant><Variation><Vertebral column><adulthood><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><backbone><brain damage><brain-injured><career><conditional knock-out><conditional knockout><critical injury><dendrite spine><density><devastating injury><developmental><electroporative delivery><epigenetically><epigenome><fetal><gene electrotransfer><homotypical cortex><hypoxic ischemic encephalopathy><improved><improved outcome><in utero><injuries><insight><isocortex><kids><mouse model><murine model><necrocytosis><neonatal HIE><neonatal brain hypoxia-ischemia><neonatal hypoxia-ischemia><neonatal hypoxic-ischemic brain damage><neonatal hypoxic-ischemic brain injury><neonatal hypoxic-ischemic encephalopathy><neopallium><neurological disease><neuron injury><neuronal><novel><overexpress><overexpression><perinatal injury><postnatal><prenatal><response><severe injury><skills><snRNA><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><translation research><translational investigation><uRNA><unborn><years lived with disability><youngster>
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GARY ARTHUR SILVERMAN

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 34/100
Solid budget
Active award
Career award
$459,000
FY 2026

Project Title

Child Health Research Center

Grant Number:

5K12HD076224-14

Activity Code:

K12

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2013

End Date:

11/30/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT This renewal application (RFA-HD-21-017) is for support of the Child Health Research Center (CHRC) at Washington University School of Medicine. Pediatric physician-scientists play a crucial role in advancing knowledge that improves child health. To meet the ongoing national ...

Research Terms

<Area><Basic Research><Basic Science><Benchmarking><Best Practice Analysis><Bioinformatics><Biology><CRISPR><CRISPR/Cas system><Cellular biology><Child Health><Child Support><Childhood><Clustered Regularly Interspaced Short Palindromic Repeats><Core Facility><Cryo-electron Microscopy><Cryoelectron Microscopy><Development><Developmental Biology><Discipline><Disease><Disorder><Doctor of Philosophy><Education><Educational aspects><Electron Cryomicroscopy><Faculty><Feedback><Generations><Genetic><Genomics><Goals><Image><Immunology><Institution><Investigation><Investigators><K12><K12 Award><K12 Mechanism><K12 Program><Knowledge><Laboratories><Leadership><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mentored Clinical Scientist Development Program><Mentors><Pathway interactions><Ph.D.><PhD><Physicians><Play><Research><Research Personnel><Researchers><Role><Scientist><Systems Biology><Training><Universities><Washington><animal model development><benchmark><biomedical resource><career development><cell biology><cryo-EM><cryoEM><cryogenic electron microscopy><developmental><experience><genome editing><genomic editing><imaging><improved><innovate><innovation><innovative><medical college><medical schools><metabolism measurement><metabolomics><metabonomics><metagenome sequencing><metagenomic sequencing><next generation><pathway><pediatric><pediatric department><programs><responsible research conduct><role model><school of medicine><social role><statistics><transcriptomics>
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Lily S Cheng

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Exploratory lead · 30/100
Very recent
Active award
$121,125
FY 2026

Project Title

Engineering a gut-on-chip model to study biomechanical forces on the enteric nervous system

Grant Number:

1R03DK144289-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Chronic idiopathic constipation is a functional gastrointestinal disorder that affects up to 1 in 5 children. As a pediatric surgeon, often the only effective treatments I can offer are intestinal resection or diversion. Thus, I strive to better understand the mechanisms that result...

Research Terms

<0-11 years old><21+ years old><3-D><3-Dimensional><3D><Abscission><Adult><Adult Human><Affect><Aganglionic Megacolon><Alimentary Canal><American><Behavior><Biologic Models><Biological Models><Biomechanics><Body Tissues><CNS Nervous System><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Communication and Signaling><Cell Culture Techniques><Cell Signaling><Cell Therapy><Cellular biology><Central Nervous System><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical Investigator Award><Co-culture><Cocultivation><Coculture><Coculture Techniques><Congenital Megacolon><Constipation><Data><Digestive Tract><Disease><Disorder><Dysfunction><Engineering><Enteral><Enteric><Enteric Nervous System><Environment><Excision><Exhibits><Extirpation><Fluorescence Activated Cell Sorting Fractionation><Fluorescence-Activated Cell Sorting><Fluorescence-Activated Cell Sortings><Foundations><Functional Gastrointestinal Disorders><Functional disorder><Future><GI Tract><Gastrointestinal Diseases><Gastrointestinal Motility><Gastrointestinal Tract><Gastrointestinal tract structure><Gene Modified><Glia><Glial Cells><Goals><Hirschsprung Disease><Hospitals><In Vitro><Individual><Intestinal><Intestines><Intracellular Communication and Signaling><Investigators><Ion Channel><Ionic Channels><K-Awards><K-Series Research Career Programs><K08 Mechanism><K08 Program><Knowledge><Kolliker's reticulum><Lead><Location><Measures><Mechanics><Mechanoreceptors><Mediating><Mediator><Membrane Channels><Methodology><Methods><Mice><Mice Mammals><Microfluidics><Model System><Modeling><Molecular><Molecular Biology Techniques><Morphology><Murine><Mus><Nerve Cells><Nerve Unit><Nervous System Physiology><Neural Cell><Neural Stem Cell><Neuraxis><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic function><Neurological function><Neurons><Non-neuronal cell><Nonneuronal cell><Paracrine Communication><Paracrine Signaling><Pathogenesis><Pathologic><Patients><Pb element><Phenotype><Physicians><Physiologic><Physiological><Physiology><Physiopathology><Piezo 1><Piezo 1 ion channel><Piezo1><Play><QOL improvement><Removal><Research Career Program><Research Methodology><Research Methods><Research Personnel><Researchers><Role><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Stress><Stretching><Structure><Surgeon><Surgical Removal><System><Testing><Time><Tissues><United States><Visit><Work><adulthood><aganglionosis><alimentary tract><biological signal transduction><biomechanical><bowel><cell based intervention><cell biology><cell culture><cell cultures><cell mediated intervention><cell mediated therapies><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><child patients><chip model><chip system><digestive canal><dysmotility><dysmotility syndrome><effective therapy><effective treatment><gastrointestinal><gastrointestinal disorder><gastrointestinal function><gene modification><genetically modified><heavy metal Pb><heavy metal lead><improvements in QOL><improvements in quality of life><in vitro Model><in vivo Model><innovate><innovation><innovative><kids><life span><lifespan><mechanic><mechanical><mechanical drive><mechanical properties><motility disorder><mouse model><murine model><nerve cement><nerve stem cell><nervous system function><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><new technology><novel><novel technologies><on a chip><on chip><organ chip><organ on a chip><organ on chip><pathophysiology><pediatric><pediatric patients><pelvirectal achalasia><postnatal><progenitor and neural stem cells><progenitor cell proliferation><progenitor proliferation><quality of life improvement><research and methods><resection><response><shear stress><skills><social role><stem and progenitor cell proliferation><stem cell proliferation><stressor><synergism><three dimensional><translational impact><youngster><µfluidic>
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Hayden B Bosworth

DURHAM VA MEDICAL CENTER, DURHAM, NC

Exploratory lead · 30/100
Very recent
Active award
$0
FY 2026

Project Title

HSR&D Senior Research Career Scientist Award

Grant Number:

5IK6HX003161-07

Activity Code:

IK6

Mechanism:

Other

Agency:

VA

Start Date:

4/1/2020

End Date:

2/28/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This renewal of a Senior Research Career Scientist (SRCS) award is to support Dr. Hayden Bosworth to further provide scientific, mentoring and service contributions to Veterans. Dr. Bosworth’s main research interests comprise 3 overarching areas that align with VA HSR&D and the VA secretary’s top pr...

Research Terms

<AIDS Virus><AIDS focused research><AIDS related research><AIDS research><AIDS science><AIDS specific research><Access to Care><Achievement><Achievement Attainment><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adherence><Adoption><Aging><American Heart Association><Analgesic Management><Apoplexy><Area><Award><Behavior><Books><Brain Vascular Accident><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Chronic><Chronic Care><Chronic Disease><Chronic Illness><Circulation><Clinical><Clinical Trials><Collaborations><Communication><Computerized Medical Record><Counseling><Curriculum><De-implementation><Dedications><Deimplementation><Development><Doctor of Philosophy><Educational Curriculum><Educational process of instructing><Effectiveness><Effectiveness of Interventions><Electronic Medical Record><Enrollment><Ensure><Evaluation><Faculty><Focus Groups><Foundations><Funding><Goals><Grant><Guidelines><HINTS><HIV><HIV focused research><HIV investigation><HIV related research><HIV research><HIV science><HIV specific research><Health Care Systems><Health Information National Trends Survey><Health Sciences><Health Services><Health Services Accessibility><Health Services Evaluation><Health Services Research><Health system><Heart Vascular><Heterogeneity><Home><Homogeneously Staining Region><Human Immunodeficiency Viruses><Hypertension><Improve Access><Individual><Industry><International><Intervention><Intervention Studies><Investigation on HIV><Investigator-Initiated Research><Investigators><K-Awards><K-Series Research Career Programs><K12><K12 Award><K12 Mechanism><K12 Program><Knowledge><LAV-HTLV-III><Lead><Leadership><Legislation><Low Literacy Population><Lymphadenopathy-Associated Virus><Medicaid><Medical Care Research><Medication Management><Mentored Clinical Scientist Development Program><Mentors><Mentorship><Meta-Analysis><Methodology><Methods><Mission><Modeling><Monitor><NHLBI><NIH><National Heart, Lung, and Blood Institute><National Institutes of Health><North Carolina><Outcome><Paper><Patient Education><Patient Instruction><Patient Training><Patient-Centered Care><Patients><Pb element><Peer Review><Ph.D.><PhD><Pharmacists><Pharmacologic Management><Population><Postdoc><Postdoctoral Fellow><Preventative care><Preventive care><Primary Care><Principal Investigator><Program Appropriateness><Provider><Publications><Publishing><QOC><Qualitative Methods><Quality of Care><R-Series Research Projects><R01 Mechanism><R01 Program><Recommendation><Reporting><Research><Research Associate><Research Career Program><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Resources><Risk><Risk Management><Risk Reduction><Role><Rural><Rural Health><Scholars Program><Scientific Publication><Scientist><Self Management><Service delivery model><Service model><Services><Statutes and Laws><Stroke><Study Section><System><Teaching><Technology><Telemedicine><Testing><Time><Training><Translating><United Kingdom><United States National Institutes of Health><Update><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Veterans><Virus-HIV><Work><access to health services><access to services><access to treatment><accessibility to health services><availability of services><brain attack><cardiovascular disorder><cardiovascular risk><cardiovascular risk factor><care access><care as usual><care coordination><care delivery model><career><cerebral vascular accident><cerebrovascular accident><chronic disorder><circulatory system><co-morbid><co-morbidity><comorbidity><complex chronic conditions><connected care><connected health care><coordinating care><developmental><disparity elimination><disparity in care><disparity in health care><effectiveness trial><eliminate disparities><eliminating disparities><enroll><health and care delivery><health care delivery><health care delivery model><health care disparity><health care inequality><health care inequity><health care quality><health delivery systems><health service access><health services availability><health services delivery><heavy metal Pb><heavy metal lead><high blood pressure><homes><hsr><human immunodeficiency virus research><hyperpiesia><hyperpiesis><hypertension control><hypertension management><hypertensive disease><hypertensive disorder><implementation science><improved><indexing><interest><intervention research><interventional research><interventional study><interventions research><lesson plans><medication therapy management><member><nursing intervention><operation><operations><patient response><patient specific response><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><population health><post intervention><post-doc><post-doctoral><post-doctoral trainee><pragmatic effectiveness trial><pragmatic trial><programs><qualitative reasoning><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><research addressing HIV><research associates><research in HIV><research into HIV><research into practice><research on HIV><research on human immunodeficiency virus><research study><research to address HIV><research to practice><response><response to therapy><response to treatment><responsive patient><risk-reducing><rural health care><rural locality><rural place><rural setting><science on HIV><science to address HIV><self-management program><service availability><services research><social role><stroked><strokes><studies on HIV><telephone based><therapeutic response><therapy response><treatment access><treatment as usual><treatment effect><treatment response><treatment responsiveness><uptake><usual care><virtual assessment><virtual care><virtual evaluation><virtual health care><virtual model><work group><working group>
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Gunnar Hargus

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 26/100
Training-friendly
Career award
$193,536
FY 2025

Project Title

Elucidating the Role of Microglia and Neurotrophin Receptor p75 on Neuronal Degeneration in Frontotemporal Dementia

Grant Number:

5K08NS116166-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/15/2021

End Date:

12/31/2025

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Frontotemporal dementia (FTD) comprises a group of early-onset neurodegenerative diseases characterized by widespread neuronal degeneration in the central nervous system leading to impairment of behavior, language and cognition. As for other forms of dementias, mechanisms of neurodegeneration are on...

Research Terms

<AD dementia><Address><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amentia><Area><Assay><Astrocytes><Astrocytus><Astroglia><Autopsy><Award><Bioassay><Biological Assay><Body Tissues><Brain><Brain Nervous System><CNS Nervous System><Cell Body><Cell Communication and Signaling><Cell Death><Cell Death Induction><Cell Signaling><Cell Survival><Cell Transplantation><Cell Viability><Cells><Cellular Stress><Cellular Stress Response><Central Nervous System><Cessation of life><Co-culture><Cocultivation><Coculture><Coculture Techniques><Cognition><Comparative Study><Control Groups><Data><Death><Degenerative Neurologic Disorders><Dementia><Development><Disease><Disorder><Down-Regulation><Encephalon><Engraftment><Expression Signature><FTD dementia><Frontal Temporal Dementia><Frontotemporal Dementia><GP80-LNGFR><Gene Expression Profile><Glia><Glial Cells><Goals><High Prevalence><Histologic><Histologically><Hortega cell><Human><IFN-Gamma-Inducing Factor Gene><IFN-gamma-Inducing Factor><IGIF><IGIF Gene><IL-1 Gamma><IL-1 Gamma Gene><IL-18><IL-18 Gene><IL-1g><IL-1g Gene><IL18><IL18 Protein><IL18 gene><IL1F4><IL1F4 Gene><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunosuppressed Host><In Vitro><Individual><Induced pluripotent stem cell derived neurons><Inflammatory><Interferon-Gamma-Inducing Factor Gene><Interferon-gamma-Inducing Factor><Interleukin 18 (Interferon-Gamma-Inducing Factor)><Interleukin 18 (Interferon-Gamma-Inducing Factor) Gene><Interleukin 18 Proprotein><Interleukin 18 Proprotein Gene><Interleukin-1 Gamma><Interleukin-1 Gamma Gene><Interleukin-18><Interleukin-18 Precursor><Interleukin-18 Precursor Gene><Intracellular Communication and Signaling><Kolliker's reticulum><Language><Ligands><Link><Low-Affinity Nerve Growth Factor Receptor><MGC12320><MGC12320 Gene><Mediating><Mediator><Mice><Mice Mammals><Microglia><Modern Man><Molecular Analysis><Murine><Mus><NGF Receptor><NGF Receptors><NGFR Protein><Nerve Cells><Nerve Degeneration><Nerve Growth Factor Receptor><Nerve Growth Factor Receptor p75><Nerve Growth Factor Receptors><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neuraxis><Neurites><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neuroglia><Neuroglial Cells><Neurologic Degenerative Conditions><Neuron Degeneration><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neurons><Neurotrophic Factor Receptor><Neurotrophin Receptors><Neurotropin Receptor p75><Non-neuronal cell><Nonneuronal cell><Pathogenesis><Pathologic><Pathway interactions><Patients><Play><Population><Predisposition><Primary Senile Degenerative Dementia><Risk><Role><Signal Induction><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Site><Stress><Substantia Nigra><Substantia nigra structure><Surface><Susceptibility><Testing><Therapeutic><Tissues><Training><Transplantation><abnormal tau><astrocytic glia><behavioral impairment><biological signal transduction><brain tissue><brain-derived neurotrophic factor precursor><career development><cell stress><cellular transplant><curative intervention><curative therapeutic><curative therapy><curative treatments><cytokine><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><early onset><front temporal dementia><frontal cortex><frontal lobe><frontal lobe dementia><frontotemporal lobar degeneration dementia><frontotemporal lobar dementia><frontotemporal lobe degeneration associated with dementia><gene corrected><gene correction><gene expression pattern><gene expression signature><genomic correction><gitter cell><glial activation><glial cell activation><global gene expression><global transcription profile><gp75 NGFR><human progenitor><human stem cells><iPS><iPS neurons><iPSC><iPSC derived-neurons><iPSCs><imaging study><immunosuppressed patient><impaired behavior><improved><in vivo><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell neurons><induced pluripotent stem cells derived from patients><induced pluripotent stem cells from patients><inducible pluripotent cell><inducible pluripotent stem cell><insight><knock-down><knockdown><mesoglia><microglial cell><microgliocyte><microtubule associated protein tau mutation><microtubule-associated protein tau mutation><mutant tau><mutation in microtubule associated protein tau><mutation in microtubule-associated protein tau><necrocytosis><necropsy><nerve cell death><nerve cell loss><nerve cement><neural><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative dementia><neurodegenerative illness><neurological degeneration><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><neuronal survival><neurons derived from induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><neurotrophic factor><neurotrophin><neutrophin><novel><overexpress><overexpression><p75 neurotrophin receptor><p75NTR><pathogenic tau><pathogenic tau gene mutation><pathological change in tau><pathway><patient derived human iPS><patient derived human iPSC><patient derived human induced pluripotent stem cell><patient derived iPS><patient derived iPSC><patient derived induced pluripotent cells><patient derived induced pluripotent stem cells><patient-derived pluripotent stem cells><perivascular glial cell><postmortem><primary degenerative dementia><pro-BDNF><progenitor cell model><progenitor model><programs><sNuc-Seq><senile dementia of the Alzheimer type><single cell analysis><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><synapse formation><synaptogenesis><tau abnormality><tau intronic mutation><tau mutation><tau pathological change><transcriptional profile><transcriptional signature><transcriptome><transplant><τ mutation>
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Leo Le Wang

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 26/100
Training-friendly
Career award
$174,420
FY 2025

Project Title

Hydrogel Therapies for Alopecia Areata

Grant Number:

1K08AR084610-01A1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2025

End Date:

7/31/2025

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Proposal Summary/Abstract Candidate: Dr. Leo Wang holds a BA, MS, MD, and PhD from the University of Pennsylvania, where he is currently completing dermatology residency and a postdoctoral fellowship. Since 2018, Dr. Wang has been working with Dr. George Cotsarelis, MD, with a primary focus on bioma...

Research Terms

<(IFN) α><(IFN)-α><(IFN)α><Address><Aldara><Alferon><Alopecia><Alopecia Areata><Animal Model><Animal Models and Related Studies><Animals><Area><Assay><Autoimmune Diseases><Award><Baldness><Behavior><Binding><Bioassay><Bioavailability><Biocompatible Materials><Biological Assay><Biological Availability><Biology><Biomaterials><Biometrics><Biometry><Biostatistics><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood Serum><Body Tissues><Cancers><Cardiac><Cardiac infarction><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><Cell-Mediated Lympholytic Cells><CellLine><Cells><Cellular biology><Chemicals><Chemistry><Clinical><Clinical Trials><Clotting><Coagulation><Coagulation Process><Collaborations><Core Facility><Cutaneous Disorder><Cytolytic T-Cell><Cytotoxic T Cell><Cytotoxic T-Lymphocytes><Dermatologist><Dermatology><Dermatoses><Development><Disease><Disorder><Disulfides><Doctor of Philosophy><Drug Delivery><Drug Delivery Systems><Drug Kinetics><Drugs><Effectiveness><Engineering><Ensure><Environment><Epidemiology><Event><FDA approved><Faculty><Fellowship><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Formulation><Fostering><Funding><Future><Generalized Growth><Growth><Hair><Hair Bulb><Hair Diseases><Hair Disorder><Hair bulb structure><Health Care Providers><Health Personnel><Histologic><Histologically><Human><Hyaluronic Acid><Hydrogels><Hydrogen Oxide><IFN Alpha><IFN α><IFN-α><IFNa><IFNα><Imaging Procedures><Imaging Technics><Imaging Techniques><Imiquimod><Immune><Immunes><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Immunology><In Vitro><Infection><Inflammation><Inflammatory><Inflammatory Response><Injectable><Injections><Interferon Alfa-n3><Interferon-α><International><Intracellular Communication and Signaling><Investigators><JAK kinase><Janus kinase><LC/MS><Leukocyte Interferon><Luciferase Immunologic><Luciferases><Lymphoblast Interferon><Lymphoblastoid Interferon><MALD-MS><MALDI><MALDI-MS><Malignant Neoplasms><Malignant Tumor><Measurement><Measures><Mediating><Medication><Mentors><Mentorship><Mercaptans><Mercapto Compounds><Methacrylates><Methods><Mice><Mice Mammals><Modeling><Modern Man><Molecular Interaction><Murine><Mus><Myocardial Infarct><Myocardial Infarction><NIAMS><National Institute of Arthritis, and Musculoskeletal, and Skin Diseases><Nitriles><Nuclear Magnetic Resonance><Oral><Pathogenesis><Patients><Penetrance><Pennsylvania><Performance><Ph.D.><PhD><Pharmaceutical Preparations><Pharmacokinetics><Pharmacology><Physiologic Availability><Plasma><Plasma Serum><Polymers><Population><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Property><QOL><Quality of life><Reaction><Research><Research Associate><Research Personnel><Research Proposals><Researchers><Residencies><Reticuloendothelial System, Serum, Plasma><Risk><STAT protein><Serum><Signal Pathway><Signal Transducer and Activator of Transcription><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Skin Diseases><Skin Diseases and Manifestations><Specialist><Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization><Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization><Strains Cell Lines><Sulfhydryl Compounds><Swelling><System><T-Cells><T-Lymphocyte><Technology><Testing><Thiols><Time><Tissue Grafts><Tissue Growth><Tissues><Topical Drug Administration><Topical application><Toxic effect><Toxicities><Training><Universities><Water><absorption><adduct><alopecia circumscripta><apply topically><authority><autoimmune condition><autoimmune cutaneous disease><autoimmune dermatologic disease><autoimmune dermatologic disorder><autoimmune dermatoses><autoimmune disorder><autoimmune skin condition><autoimmune skin disease><autoimmune skin disorder><autoimmunity disease><biological material><biological signal transduction><biomaterial development><cardiac infarct><career preparation><career readiness><cell biology><clinical translation><clinically translatable><co-morbid><co-morbidity><comorbidity><compare to control><comparison control><coronary attack><coronary infarct><coronary infarction><crosslink><cultured cell line><cutaneous disease><deliver topically><dermal disease><dermal disorder><developmental><disease model><disorder model><draining lymph node><drug distribution><drug/agent><epidemiologic><epidemiological><flow cytophotometry><health care personnel><health care worker><health provider><health workforce><heart attack><heart infarct><heart infarction><human tissue><imaging mass spectrometry><improved><in vivo><in vivo Model><innovate><innovation><innovative><intradermal injection><job readiness><killer T cell><kinase inhibitor><liquid chromatography mass spectrometry><malignancy><mass spectrometric imaging><materials science><matrix assisted laser desorption ionization><mechanical properties><medical personnel><model of animal><mouse model><murine model><neoplasm/cancer><novel><ontogeny><patchy loss of hair><pelade><polymer><polymeric><post-doc><post-doctoral><post-doctoral trainee><prevent><preventing><professor><regional lymph node><research associates><self assembly><skin disorder><skin heterograft><skin xenograft><sulfhydryl group><systemic toxicity><therapeutic agent development><therapeutic development><thymus derived lymphocyte><tissue grafting><topical administration><topical delivery><topical drug application><topical drug delivery><topical instillation><topical treatment><translational opportunities><translational potential><translational therapeutics><translational therapy><treat topically><treatment provider><venous thromboembolism><work readiness><workforce readiness><workplace readiness>
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Rina S Fox

UNIVERSITY OF ARIZONA, TUCSON, AZ

Exploratory lead · 26/100
Training-friendly
Career award
$172,131
FY 2025

Project Title

Improving sleep in gynecologic cancer survivors

Grant Number:

5K08CA247973-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2021

End Date:

1/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Sleep disturbance is one of the primary complaints of gynecologic cancer survivors, with more than 80% of survivors reporting sleep difficulties. Sleep disturbance also contributes to worsened health-related quality of life (HRQOL) and increased symptom burden. Although non-pharmaco...

Research Terms

<Active Follow-up><Address><Adherence><Affect><After Care><After-Treatment><Aftercare><Automobile Driving><Autoregulation><Beds><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biometrics><Biometry><Biostatistics><Cancer Control><Cancer Control Science><Cancer Survivor><Cancer Survivorship><Cancers><Circadian Dysregulation><Circadian Rhythms><Clinical><Clinical Investigator Award><Cognition Therapy><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive Psychotherapy><Cognitive Therapy><Cognitive decline><Cognitive function abnormal><Cognitive treatment><Conditioning Therapy><Data><Depressed mood><Development Plans><Disease><Disorder><Disturbance in cognition><Elements><Eligibility><Eligibility Determination><Fatigue><Feedback><Female Reproductive Cancer><Foundations><Funding><Future><Goals><Gynecologic Cancer><Gynecologic Oncology><Gynecological Cancer><High Prevalence><History><Homeostasis><Impaired cognition><Individual><Insomnia><Insomnia Disorder><Interdisciplinary Research><Interdisciplinary Study><Intervention><Interview><Investigators><Israel><K08 Mechanism><K08 Program><Lack of Energy><Light><Malignant Female Reproductive System Neoplasm><Malignant Gynecologic Neoplasm><Malignant Gynecologic Tumor><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Female Reproductive System><Measures><Mediating><Medicine><Melatonin><Mentors><Mentorship><Methodology><Modeling><Multidisciplinary Collaboration><Multidisciplinary Research><Nature><Non-pharmacologic Therapy><Nonpharmacologic Intervention><Nonpharmacologic Therapy><Nonpharmacologic approach><Nonpharmacologic treatment><Nyctohemeral Rhythm><Outcome><Outcome Study><Pain><Painful><Participant><Patient Self-Report><Patients><Phase><Phase I Study><Photoradiation><Physiological Homeostasis><Population><Procedures><Process><Protocol><Protocol Screening><Protocols documentation><Qualitative Methods><Qualitative Research><Questionnaires><Randomized><Randomized, Controlled Trials><Recommendation><Recording of previous events><Relaxation Therapy><Reporting><Research><Research Methodology><Research Methods><Research Personnel><Researchers><Role><Sampling><Self-Report><Sleep><Sleep disturbances><Sleeplessness><Stimulus><Structure><Survivors><Symptom Burden><Testing><Time><Training><Treatment Efficacy><Twenty-Four Hour Rhythm><Urine><Work><Wrist><aberrant sleep><actigraph><actigraphy><active followup><alleviate symptom><ameliorating symptom><behavior intervention><behavioral intervention><behavioral sleep health intervention><behavioral sleep health program><behavioral sleep intervention><behavioral sleep strategies><behavioral sleep therapy><behavioral sleep treatment><biobehavior><biobehavioral><career development><circadian><circadian abnormality><circadian biology><circadian disruption><circadian disturbance><circadian dysfunction><circadian impairment><circadian process><circadian rhythmicity><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><cognitive dysfunction><cognitive loss><daily biorhythm><decrease symptom><depressed><design><designing><determine efficacy><develop therapy><disrupted sleep><disturbed sleep><driving><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experience><exposure to light><exposure to visible light><fewer symptoms><follow up><follow-up><followed up><followup><gynecologic malignancy><gynecological malignancy><health related quality of life><histories><impaired sleep><improved><improvement on sleep><innovate><innovation><innovative><intervention delivery><intervention development><intervention effect><intervention efficacy><irregular sleep><light exposure><light pollution exposure><malignancy><multidisciplinary><multiphase optimization strategy><neoplasm/cancer><non-drug therapy><non-drug treatment><nondrug therapy><nondrug treatment><personalized health intervention><personalized intervention><phase 1 study><post intervention><post treatment><precision interventions><primary outcome><programs><psychosocial><qualitative reasoning><quality of sleep><randomisation><randomization><randomized control trial><randomly assigned><recruit><reduce symptoms><relaxation training><relieves symptoms><research and methods><retention rate><retention strategy><sadness><secondary outcome><sleep control><sleep difficulty><sleep disruption><sleep dysregulation><sleep health><sleep hygiene><sleep improvement><sleep quality><sleep regulation><sleep wellness><sleep/wake disruption><sleep/wake disturbance><sleep/wake regulation><social role><standard care><standard treatment><symptom alleviation><symptom reduction><symptom relief><therapeutic efficacy><therapy development><therapy efficacy><treatment adherence><treatment compliance><treatment development><treatment effect><trial design><urinary>
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MARTIN S TAYLOR

BROWN UNIVERSITY, PROVIDENCE, RI

Exploratory lead · 26/100
Training-friendly
Career award
$166,860
FY 2025

Project Title

Elucidating structural, mechanistic, and allosteric determinants of mTOR Complex 2 (mTORC2) signaling.

Grant Number:

7K08DK129824-06

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/15/2021

End Date:

3/4/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Taylor, Martin | K08 (PA-20-203) | PROJECT SUMMARY / ABSTRACT This proposal details a five-year training plan for the development of a research program focused on elucidating structural, mechanistic, and allosteric determinants of mTOR Complex 2 (mTORC2) signaling. Phosphorylation of the signaling k...

Research Terms

<1-Phosphatidylinositol 3-Kinase><Active Follow-up><Address><Adult-Onset Diabetes Mellitus><Affect><Affinity><Aging><Allosteric Regulation><Apoptosis><Apoptosis Pathway><Assay><Autophagocytosis><Autoregulation><Award><Binding><Bioassay><Biochemical><Bioinformatics><Biological Assay><Biology><Biomedical Research><Bourneville Disease><Bourneville Phakomatosis><Bourneville syndrome><Bourneville-Brissaud disease><Bourneville-Pringle syndrome><Cancers><Catabolic Process><Catalysis><Cell Communication and Signaling><Cell Locomotion><Cell Migration><Cell Movement><Cell Signaling><Cellular Expansion><Cellular Growth><Cellular Matrix><Cellular Migration><Cellular Motility><Chemicals><Clinical><Collaborations><Color><Complex><Cryo-electron Microscopy><Cryoelectron Microscopy><Cytoskeletal System><Cytoskeleton><Data><Data Analyses><Data Analysis><Development><Development Plans><Development and Research><Diabetes Mellitus><Disease><Disorder><Drugs><Dysfunction><Electron Cryomicroscopy><Ensure><Epiloia><Eukaryotic Cell><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Feedback><Fostering><Functional disorder><General Hospitals><Generalized Growth><Generations><Glucose Binding Protein><Glucose Transport Protein><Glucose Transporter><Goals><Growth><Growth Agents><Growth Factor><Growth Substances><Homeostasis><Hospital Departments><Human><Humulin R><Hypertension><Impairment><Institution><Insulin><Insulin Receptor><Insulin Receptor Protein-Tyrosine Kinase><Insulin Resistance><Insulin-Dependent Tyrosine Protein Kinase><International><Intracellular Communication and Signaling><Investigators><Ion Channel><Ionic Channels><Ketosis-Resistant Diabetes Mellitus><Kinases><Kinetics><Knowledge><Learning><Malignant Neoplasms><Malignant Tumor><Maps><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Massachusetts><Maturity-Onset Diabetes Mellitus><Measures><Mechanistic Target of Rapamycin><Medication><Membrane Channels><Mentors><Metabolic><Metabolic syndrome><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Modern Man><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Monomeric G-Proteins><Monomeric GTP-Binding Proteins><NIDDM><Neoplasm Metastasis><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Novolin R><Nutrient><Oncogenic><PI-3 Kinase><PI3-Kinase><PI3CG><PI3KGamma><PI3k><PIK3><PIK3CG><PIK3CG gene><Pathologist><Pathology><Pathway interactions><Pharmaceutical Preparations><Phosphatidylinositol 3-Kinase><Phosphatidylinositol-3-OH Kinase><Phosphoinositide 3-Hydroxykinase><Phosphorylation><Phosphotransferase Gene><Phosphotransferases><Physicians><Physiological Homeostasis><Physiopathology><Play><Position><Positioning Attribute><Principal Investigator><Pringle disease><Programmed Cell Death><Proliferating><Protein Engineering><Protein Phosphorylation><Proteins><Proteins Growth Factors><Proteomics><PtdIns 3-Kinase><R & D><R&D><RAFT1><Reaction><Reagent><Regular Insulin><Regulation><Research><Research Personnel><Researchers><Resolution><Role><Science><Scientist><Secondary Neoplasm><Secondary Tumor><Series><Signal Transduction><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Small G-Proteins><Small GTPases><Solid Neoplasm><Solid Tumor><Stable Diabetes Mellitus><Structure><Substrate Interaction><System><T2 DM><T2D><T2DM><Techniques><Testing><Therapeutic><Time><Tissue Growth><Training><Transmission><Transphosphorylases><Treatment Failure><Tuberous Sclerosis><Type 2 Diabetes Mellitus><Type 2 diabetes><Type I Phosphatidylinositol Kinase><Type II Diabetes Mellitus><Type II diabetes><Type III Phosphoinositide 3-Kinase><Universities><Upregulation><VHH><VHH antibody><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Visualization><active followup><adenoma sebaceum><adult onset diabetes><arm><autophagy><biological signal transduction><blood glucose regulation><camelid antibody><camelid based antibody><camelid derived antibody><camelid derived fragment><camelid heavy chain only Abs><camelid immunoglobulin><camelid single chain antibody><camelid variable heavy chain><cancer metastasis><cancer type><career><career development><cell growth><cell motility><cerebral sclerosis><chemical conjugate><conformation><conformational><conformational state><conformationally><conformations><crosslink><cryo-EM><cryoEM><cryogenic electron microscopy><data interpretation><density><design><designing><develop therapy><developmental><diabetes><drug/agent><epiploia><experience><feeding><follow up><follow-up><followed up><followup><gastrointestinal><genetic protein engineering><glucose control><glucose homeostasis><glucose regulation><glucose transport><hereditary multiple system hamartomatosis><high blood pressure><human disease><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><inhibitor><insight><insulin resistant><insulin sensitivity><insulin signaling><insulin tolerance><interest><intervention development><intracellular skeleton><ketosis resistant diabetes><mTOR><mTOR inhibition><malignancy><mammalian target of rapamycin><maturity onset diabetes><nanobodies><nanobody><neoplasm/cancer><neurinomatosis centralis><neuromatosis universalis><neurospongioblastosis diffusa><novel><ontogeny><pathophysiology><pathway><phacomatosis><pharmacologic><prevent><preventing><programs><protein complex><protein design><receptor sensitivity><research and development><resolutions><rho><rho G-Proteins><rho GTP-Binding Proteins><rho GTPases><rho Protein P21><rho Small GTP-Binding Proteins><sclerosis tuberosa><sdAb><single domain antibodies><skill acquisition><skill development><small molecule><social role><spongioblastosis circumscripta><structural biology><success><therapy development><therapy failure><tool><transmission process><treatment development><tuberose sclerosis><tuberous sclerosis complex><tumor cell metastasis><type 2 DM><type II DM><type two diabetes><variable heavy chain antibody>
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Jaime Peterson

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Exploratory lead · 26/100
Training-friendly
Career award
$150,664
FY 2025

Project Title

Latino School Readiness: Engaging Pediatric and Early Childhood Systems to Adapt and Pilot Family Centered Primary Care Interventions

Grant Number:

5K08HS029353-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

AHRQ

Start Date:

3/1/2023

End Date:

2/28/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Children who enter school ready to learn are more likely to succeed academically. Yet, low-income children often enter school behind their more affluent peers. The growing population of Latino children experience economic and cultural barriers to school readiness (SR). The primary ca...

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Gina M Sequeira

SEATTLE CHILDREN'S HOSPITAL, SEATTLE, WA

Exploratory lead · 26/100
Training-friendly
Career award
$143,057
FY 2025

Project Title

Using telehealth to improve access to gender-affirming care for BIPOC and rural gender diverse youth

Grant Number:

5K08HS029028-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

AHRQ

Start Date:

4/1/2023

End Date:

3/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY This proposal aims to improve the care of specific populations included in the special emphasis notice (NOT- HS-21-014) to advance health equity by increasing health services research involving transgender and gender diverse youth, youth who identify as Black, Indigenous, or People o...

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CAROLYN O SANGOKOYA

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 26/100
Training-friendly
Career award
$142,401
FY 2025

Project Title

POST-TRANSCRIPTIONAL REGULATION OF CELL FATE IN EARLY MAMMALIAN DEVELOPMENT

Grant Number:

5K08HD105017-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2021

End Date:

3/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Post-transcriptional regulation by RNA-binding proteins (RBPs) and microRNAs (miRNAs) orchestrate diverse molecular and cellular mechanisms that pattern early mammalian development from embryonic stem cells (ESCs) through gastrulation and lineage commitment. The RBPs Ago2 (Argonaute-2) and IRP (iron...

Research Terms

<3' Untranslated Regions><3'UTR><ACO1 Protein><Address><Anatomic Sites><Anatomic structures><Anatomy><Binding><Binding Proteins><Binding Sites><Biosensor><Board Certification><Body Tissues><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Fate Control><Cell Fate Regulation><Cell Signaling><Cell model><Cells><Cellular model><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Combining Site><Critical Paths><Critical Pathways><DNA Synthesis Factor><Data><Development><Development Plans><Developmental Biology><ES cell><ES cell differentiation><ESC differentiation><Embryo><Embryo Development><Embryogenesis><Embryoid bodies><Embryonic><Embryonic Development><Endocytosis><Endothelial Cell Growth Factor><Ensure><Environment><Erythropoiesis><FGF><Family><Fe element><Ferritin Repressor Protein><Fibroblast Growth Factor><Fibroblast Growth Factor Gene Family><Fibroblast Growth Regulatory Factor><Five-Year Plans><Future><Gene Alteration><Gene Mutation><Goals><Grant><Hepatobiliary><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Human Development><IRE-BP1><IRP-1 Protein><IRP1 Protein><Immune Precipitation><Immunoprecipitation><In Vitro><Intracellular Communication and Signaling><Iron><Iron Regulatory Factor><Iron Regulatory Protein 1><Iron-Regulatory Proteins><Iron-Response Proteins><Knowledge><Laboratories><Leadership><Learning><Ligand Binding Protein><Ligand Binding Protein Gene><Maps><Mediating><Mentored Clinical Scientist Development Award (K08)><Mentored Clinical Scientists Development Award><Mentors><Messenger RNA><Methods><MicroRNAs><Modeling><Molecular><Molecular Interaction><Nucleotides><Operative Procedures><Operative Surgical Procedures><Organogenesis><Pathologist><Pathology><Pathway interactions><Pattern><Phased Career Development><Physicians><Post-Transcriptional Control><Post-Transcriptional Regulation><Process><Productivity><Progenitor Cells><Protein Binding><RNA-Binding Proteins><Reactive Site><Regulation><Reporter><Research><Resolution><Role><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Site><Soluble Aconitase 1><Specific qualifier value><Specified><Statistical Methods><Stem cell pluripotency><Surgical><Surgical Interventions><Surgical Procedure><Technical Expertise><Testing><Tissues><Training><Transcript><biological sensor><biological signal transduction><bound protein><career development><cellular differentiation><crosslink><developmental><differentiation in embryonic stem cells><embryo derived stem cell><embryonal stem cells><embryonic precursor differentiation><embryonic progenitor><embryonic stem cell><embryonic stem cell differentiation><erythroid development><functional genomics><gastrointestinal><gastrulation><gene defect><global gene expression><global transcription profile><in vivo><mRNA><miRNA><mouse model><multidisciplinary><murine model><mutant><mutant allele><neurogenesis><pathway><pluripotency><pluripotent state><post-transcriptional gene regulation><profilin><progenitor biology><progenitor cell biology><progenitor cell fate><progenitor cell regeneration><progenitor cell self renewal><progenitor fate><progenitor regeneration><progenitor self renewal><regeneration based therapy><regeneration therapy><regenerative therapeutics><regenerative therapy><resolutions><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><statistic methods><stem and progenitor biology><stem and progenitor cell fate><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem cell biology><stem cell fate><stem cell of embryonic origin><stem cell regeneration><stem cell self renewal><stem cells><surgery><technical skills><tool><transcriptome>
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Shah Rukh Ali

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 26/100
Training-friendly
Career award
$135,000
FY 2025

Project Title

Role of IGFBP3 in Neonatal Heart Regeneration

Grant Number:

5K08HL153788-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract This is an application for a K08 award for Dr. Shah Ali, MD, an Instructor in Cardiology at the University of Texas Southwestern (UTSW), for his transition from Instructor to independent investigator in basic cardiovascular biology with a focus on cardiac regeneration. He h...

Research Terms

<21+ years old><Abscission><Address><Adult><Adult Human><Advisory Committees><Age><Apical><Award><Beta Cell><Binding><Biology><Blood Serum><Blood Vessels><Body Tissues><California><Candidate Disease Gene><Candidate Gene><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac Transplantation><Cardiac infarction><Cardiocyte><Cardiology><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Career Counseling><Career Guidance><Cause of Death><Cell Body><Cell Communication and Signaling><Cell Count><Cell Cycle Arrest><Cell Death><Cell Lineage><Cell Number><Cell Signaling><Cell Transplantation><Cell division><Cell secretion><Cells><Cellular Secretion><Cessation of life><Cicatrix><Data><Death><Deterioration><Development><Developmental Biology><Drugs><Endothelial Cells><Endothelium><Excision><Exhibits><Extirpation><Failure><Fellowship><Fibroblasts><Genetic Models><Health Care Systems><Heart><Heart Diseases><Heart Grafting><Heart Muscle Cells><Heart Transplantation><Heart Vascular><Heart failure><Heart myocyte><Human><IGF-Binding Protein 3><IGF-Binding Proteins><IGF2><IGF2 gene><IGFBP><IGFBP-3><Impairment><Injury><Insulin Cell><Insulin Receptor><Insulin Receptor Protein-Tyrosine Kinase><Insulin Secreting Cell><Insulin-Dependent Tyrosine Protein Kinase><Insulin-Like Growth Factor Binding Protein 3><Insulin-Like Growth-Factor-Binding Proteins><Internal Medicine><Intracellular Communication and Signaling><Investigators><Ischemic Heart><Ischemic Heart Disease><Ischemic myocardium><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Laboratories><Laboratory Study><Life><M Phase><Maps><Mechanics><Mediating><Medication><Mentors><Mice><Mice Mammals><Micro Array Data><Mitogens><Mitosis><Mitosis Stage><Mitotic><Modern Man><Molecular><Molecular Interaction><Murine><Mus><Muscle Cells><Myocardial Infarct><Myocardial Infarction><Myocardial Ischemia><Myocytes><Natural regeneration><Neonatal><Null Mouse><Occupational Guidance><Operative Procedures><Operative Surgical Procedures><Organ><Output><Patients><Pharmaceutical Preparations><Physicians><Proliferating><Protein Family><Protein Secretion><Proteins><Recombinant Insulin-Like Growth Factor><Recombinants><Regeneration><Removal><Research><Research Personnel><Researchers><Residencies><Rh IGF><Rh Insulin Like Growth Factor><Role><San Francisco><Scars><Scientist><Serum><Signal Induction><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Somatomedin-Binding Proteins><Source><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><Task Forces><Texas><Tissues><Training><Translating><Universities><Ventricular><Vocational Counseling><Vocational Guidance><Writing><adulthood><advisory team><aged mice><aged mouse><ages><biological signal transduction><cardiac failure><cardiac function><cardiac graft><cardiac infarct><cardiac ischemia><cardiac regeneration><cardiomyocyte><cardiovascular disorder><career counselor><career development><cell type><cellular transplant><circulatory system><conditional knock-out><conditional knockout><coronary attack><coronary infarct><coronary infarction><coronary ischemia><defined contribution><developmental><drug/agent><elderly mice><executive coaching><experience><experiment><experimental research><experimental study><experiments><function of the heart><health care burden><heart attack><heart disorder><heart function><heart infarct><heart infarction><heart ischemia><heart regeneration><heart transplant><improved><injuries><injury response><insight><instructor><insulinlike growth factor binding protein><ischemic cardiomyopathy><mechanic><mechanical><mouse model><murine model><mutant><myocardial ischemia/hypoxia><myocardium ischemia><necrocytosis><neonatal injury><neonatal mice><neonate><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><old mice><overexpress><overexpression><paracrine><regenerate><regeneration based therapy><regeneration therapy><regenerative><regenerative therapeutics><regenerative therapy><resection><response to injury><social role><spatial and temporal><spatial temporal><spatiotemporal><surgery><therapeutic candidate><vascular><β-cell><β-cells><βCell>
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Joshua Ethan Motelow

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 26/100
Training-friendly
Career award
$123,744
FY 2025

Project Title

Genetic Risk Underlying Pediatric Critical Illness

Grant Number:

5K08HG012374-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/22/2023

End Date:

1/2/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Children rarely become critically ill. I hypothesize that genetic risk contributes to unexpected pediatric critical illness. Identifying risk groups allows for clinical stratification and targeted therapies, but these benefits can only be realized if risk is known. This prop...

Research Terms

<0-11 years old><Acute Kidney Failure><Acute Kidney Insufficiency><Acute Renal Failure><Acute Renal Insufficiency><Admission><Admission activity><Adverse drug event><Airway failure><Allergy><Asthma><Biological><Bronchial Asthma><Caring><Child><Child Youth><Childhood><Children (0-21)><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinical><Clinical Management><Clinical Treatment><Clinical Trials><Clinical stratification><Critical Care><Critical Illness><Critically Ill><Critically ill children><Data><Data Bases><Databases><Disease><Disorder><Doctor of Philosophy><Dose><Drugs><ELSI><Early Intervention><Enrollment><Environment><Equity><Fellowship><Future><Genes><Genetic><Genetic Risk><Genetics and Medicine><Genome><Genomics><Goals><Heterogeneity><Human Genetics><Intervention><Kidney><Kidney Urinary System><Lead><Light><Lower Respiratory Tract Infection><Lower respiratory infection><Mediating><Medical center><Medication><Medicine><Mendelian disease><Mendelian disorder><Mendelian genetic disorder><Mentors><Mentorship><Methods><Morbidity><Morbidity - disease rate><NGS Method><NGS system><Network-based><Neurosciences><Oranges><Pathway interactions><Patients><Pb element><Pediatric Intensive Care Units><Ph.D.><PhD><Pharmaceutical Preparations><Pharmacogenomics><Phenotype><Photoradiation><Physicians><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Predisposition><Primary Immunodeficiency><Proteins><Publishing><Research><Research Associate><Research Resources><Resources><Respiratory Failure><Risk><Risk Factors><Risk-associated variant><Sample Size><Sampling><Scientist><Secondary to><Source><Susceptibility><Testing><Time><Training><Universities><Variant><Variation><Viral><Viral Diseases><Virus Diseases><acute kidney injury><biologic><career development><chronic kidney disease><clinical intervention><clinical risk><clinical therapy><clinically actionable><cohort><comparable efficacy><comparative efficacy><compare efficacy><compare to control><comparison control><congenital immune deficiency><congenital immunodeficiency><critically ill child><data base><disease risk><disorder risk><drug/agent><enroll><ethical legal and social><ethical, legal, and social implication><exome><exome sequencing><exome-seq><experiment><experimental research><experimental study><experiments><gene network><genetic association><genetic immune defect><genetic immune deficiency><genetic immunodeficiency><genome sequencing><heavy metal Pb><heavy metal lead><improved><inborn errors in immunity><inborn errors of immunity><inborn immunodeficiency><inherited immune defect><inherited immune deficiency><inherited immunodeficiency><innovate><innovation><innovative><kids><loss of function><medication administration><monogenic disease><monogenic disorder><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next gen sequencing><next generation sequencing><next generation therapeutics><nextgen sequencing><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><pediatric><polygenetic risk scores><polygenic risk score><post-doc><post-doctoral><post-doctoral trainee><precision medicine><precision-based medicine><primary immune defect><primary immune deficiency><programs><renal><research associates><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><single-gene disease><single-gene disorder><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic agent development><therapeutic development><trial regimen><trial treatment><venous thromboembolism><viral infection><virus infection><virus-induced disease><youngster>
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Fotios Spyropoulos

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 26/100
Training-friendly
Career award
$62,616
FY 2025

Project Title

Oxidative Stress and Mitochondrial Dysfunction in Chemogenetic Heart Failure

Grant Number:

3K08HL168240-02S1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2023

End Date:

4/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

This K08 Mentored Clinical Scientist Career Development Award describes a five-year research and training program of the principal investigator (PI), Dr. Fotios Spyropoulos, that will enable his transition to independent scientific investigation in the field of oxidative stress-induced cardiac metab...

Research Terms

<21+ years old><Acetylation><Active Oxygen><Acute><Adult><Adult Human><Affect><Alanine><Amino Acids><Animal Model><Animal Models and Related Studies><Animals><Antioxidants><Applied Skills><Assay><Award><Bioassay><Bioenergetics><Biological Assay><Biology><Blood Vessels><Body Tissues><Bypass><Calcium><Cardiac><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular Physiology><Cardiovascular system><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Communication and Signaling><Cell Respiration><Cell Signaling><Cellular Respiration><Chronic><Clinical><Clinical Investigator Award><Coloring Agents><Complex><Complication><D-Amino Acid Dehydrogenase><D-Amino-Acid Oxidase><Data><Deacetylase><Death Rate><Dependence><Development><Disease><Disorder><Dyes><Dysfunction><Environment><Enzyme Gene><Enzymes><Equilibrium><Experimental Models><Fluorescent Probes><Functional disorder><Funding><Future><Generations><Genetic><Goals><H2O2><Heart><Heart Muscle Cells><Heart Vascular><Heart failure><Heart myocyte><Hospitals><Human><Hydrogen Peroxide><Hydroperoxide><IPO-B><Immune Precipitation><Immunoblotting><Immunoprecipitation><Impairment><In Vitro><Indophenol Oxidase B><Injury><Institution><Intracellular Communication and Signaling><Investigation><K-Awards><K-Series Research Career Programs><K08 Mechanism><K08 Program><Knowledge><Laboratories><Lead><Link><MNSOD><Manganese Superoxide Dismutase><Manuscripts><Measures><Mediating><Medical><Membrane Potentials><Mentors><Mentorship><Messenger RNA><Metabolic><Mice><Mice Mammals><Mitochondria><Mitochondrial Superoxide Dismutase><Mn Superoxide Dismutase><Mn-SOD><Modeling><Modern Man><Modification><Molecular><Morbidity><Morbidity - disease rate><Murine><Mus><Myocardium><Neonatal><Organ><Oxidants><Oxidative Stress><Oxidative Stress Induction><Oxidizing Agents><Oxygen Radicals><Pathway interactions><Pattern><Pb element><Persons><Phenotype><Physiology><Physiopathology><Predisposition><Premature Birth><Premature Infant><Prematurely delivering><Preterm Birth><Prevention><Prevention therapy><Principal Investigator><Pro-Oxidants><Protein Acetylation><Proteins><QOL><Quality of life><Reactive Oxygen Species><Recombinants><Regulation><Research><Research Career Program><Research Resources><Resources><Resting Potentials><Role><SOD2><SOD2 gene><Scholarship><Scientist><Senior Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Silent Mating Type Information Regulator 2-like Proteins><Sir2-like Proteins><Sirtuins><Superoxide Anion><Superoxide Dismutase 2><Superoxide Radical><Superoxides><Susceptibility><Testing><Time><Tissues><Training><Training Programs><Transgenic Mice><Transmembrane Potentials><Vascular blood supply><Viral Vector><Virus><Western Blotting><Western Immunoblotting><Woman><Work><Writing><Yeasts><adulthood><aerobic metabolism><aerobic respiration><aminoacid><balance><balance function><biological signal transduction><blood supply><calcium flux><calcium mobilization><cardiac failure><cardiac function><cardiac muscle><cardiomyocyte><cardiovascular function><career development><circulatory system><developmental><dextro-Amino Acid Oxidase><electron acceptor><experience><extracellular><fluorescence imaging><fluorescent imaging><function of the heart><heart function><heart muscle><heavy metal Pb><heavy metal lead><hemodynamics><improved><in vivo><infants born premature><infants born prematurely><injuries><insight><live cell image><live cell imaging><live cellular image><live cellular imaging><mRNA><medical college><medical schools><meeting><meetings><mitochondrial><mitochondrial dysfunction><model of animal><mortality><mortality rate><mortality ratio><mouse model><murine model><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><oxidant stress><oxidation><oxidative metabolism><pathophysiology><pathway><perinatal medicine><premature><premature baby><premature childbirth><premature delivery><premature infant human><prematurity><pressure><preterm baby><preterm delivery><preterm infant><preterm infant human><protein blotting><release of sequestered calcium ion into cytoplasm><response><school of medicine><social role><timeline><vascular><vascular supply>
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Resmi Charalel

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Exploratory lead · 26/100
Training-friendly
Career award
$51,079
FY 2025

Project Title

Small LIVER Cancer: Development of a Multi-Level Intervention to Improve Access to CURE (LIVER:CURE)

Grant Number:

1K08CA286847-01A1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/10/2025

End Date:

7/30/2025

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary: The long-term objective of this K08 application is to develop Dr. Resmi Charalel's capacity to discover practical solutions to achieve equitable outcomes for small hepatocellular carcinoma (HCC) patients, a cancer population where there is currently a large gap in care delivery from...

Research Terms

<Address><Ambulatory Care Nursing><Attention><Award><Black><Black race><Cancer Patient><Cancers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Clinic Nursing><Collaborations><Communication><Community Hospitals><Consultations><Data><Decrease disparity><Development><Diagnosis><Early Diagnosis><Education><Education and Training><Educational aspects><Effectiveness><Elements><Ensure><Equity><Evolution><Female><Focus Groups><Funding><Future><Goals><Grant><Groups at risk><Health Care><Health Care Utilization><Health Services><Health equity research><Hepatic Cancer><Hepatocarcinoma><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatoma><Hospitals><Image><Improve Access><Inequity><Intervention><Interview><Investigators><K-Awards><K-Series Research Career Programs><Knowledge><Learning><Liver><Liver Cells Carcinoma><Lower disparity><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of liver><Medical><Methodology><Methods><Modeling><NCCN><National Comprehensive Cancer Network><Office Nursing><Outcome><Participant><Pathway interactions><Patient Education><Patient Instruction><Patient Recruitments><Patient Training><Patients><People at risk><Persons at risk><Population><Population Heterogeneity><Populations at Risk><Primary carcinoma of the liver cells><Provider><Qualitative Research><RE-AIM><Randomization trial><Randomized, Controlled Trials><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Recommendation><Reporting><Reproducibility><Research><Research Career Program><Research Methodology><Research Methods><Research Personnel><Research in health equity><Researchers><Sampling><Schedule><Specialist><Structure><System><Testing><Time><Training><Training Activity><Training and Education><Transportation><Travel><Treatment Efficacy><Unmarried><Work><Writing><acceptability and feasibility><arm><barrier to care><barrier to health care><barrier to treatment><behavior change><cancer care><cancer disparity><cancer health disparity><cancer-related health disparity><care coordination><care delivery><cohort><compare treatment><consultation><coordinating care><curative intervention><curative therapeutic><curative therapy><curative treatments><design><designing><develop therapy><developmental><disparity in cancer><disparity reduction><diverse populations><early detection><efficacy testing><empowerment><evidence base><health care service use><health care service utilization><health equity-focused research><hepatic body system><hepatic organ system><heterogeneous population><high risk><high risk group><high risk individual><high risk people><high risk population><imaging><implementation framework><implementation research framework><implementation science><implementation science framework><improved><inadequate health literacy><innovate><innovation><innovative><intervention design><intervention development><intervention efficacy><intervention refinement><liver cancer><liver carcinoma><liver malignancy><low health literacy><male><malignancy><malignant liver tumor><minority patient><mitigate disparity><multidisciplinary><neoplasm/cancer><novel><obstacle to care><obstacle to health care><participant engagement><participant enrollment><participant recruitment><pathway><patient engagement><patient enrollment><patient navigator><patients from minority><patients of minority><pilot test><poor health literacy><population diversity><prospective><randomized control trial><randomized trial><reach, efficacy, adoption, implementation, and maintenance><recruit><reduce disparity><reduced health literacy><reduction in disparity><research and methods><research on health equity><research related to health equity><research to attain health equity><screening><screenings><skills><social><system-level barriers><tertiary care><therapeutic efficacy><therapy design><therapy development><therapy efficacy><training module><treatment comparison><treatment design><treatment development><user centered design><voucher><♀><♂>
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Rajat Maji

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Exploratory lead · 26/100
Training-friendly
Career award
$10,242
FY 2025

Project Title

Data to Design: An Integrated Approach to Developing New Synthetic Methods

Grant Number:

5K99GM151453-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/1/2024

End Date:

7/31/2025

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary Machine learning (ML)—i.e., the use of computer algorithms that can automatically learn from sampled data and make predictions or decisions without explicit programming—is increasingly important in a wide array of applications, from image and speech recognition to product recommendat...

Research Terms

<AI system><Acceleration><Active Learning><Adopted><Adoption><Agricultural Chemicals><Agrochemicals><Alkaloids><Architecture><Artificial Intelligence><Automobile Driving><Biomedical Research><Case Study><Catalysis><Chemicals><Chemistry><Collaborations><Computational algorithm><Computer Reasoning><Cooperative Learning><Coupling><Data><Data Science><Data Set><Descriptor><Development><Discipline><Engineering / Architecture><Esterification><Exercise><Experiential Learning><Feedback><Fellowship><Funding><Generations><Goals><Grant><Health><Human><Image><Industry><Industry Collaboration><Industry Collaborators><Investigators><Knowledge><Laboratories><Learning><Libraries><Link><Machine Intelligence><Machine Learning><Medicinal Chemistry><Medicine><Mentored Clinical Scientist Development Award (K08)><Mentored Clinical Scientists Development Award><Mentors><Mentorship><Methodology><Methods><Modern Man><Molecular><NIGMS><NIH><National Institute of General Medical Sciences><National Institutes of Health><Ni element><Nickel><Organic Chemistry><Organic Synthesis><Outcome><Pharmaceutic Chemistry><Pharmaceutical Chemistry><Phase><Phased Career Development><Play><Preparation><Process><Protocol><Protocols documentation><Psychological reinforcement><Rationalization><Reaction><Recommendation><Reinforcement><Reproducibility><Research><Research Personnel><Research Resources><Researchers><Resources><Role><Sampling><Science><Securinega><Strategic Planning><Structure><Synthesis Chemistry><Synthetic Chemistry><System><Technology><Time><Training><Transition Elements><United States National Institutes of Health><career><career development><case report><catalyst><chemical reaction><chemical synthesis><computer algorithm><data driven platform><data platform><design><designing><developmental><driving><experience><experiment><experimental research><experimental study><experiments><heuristics><imaging><improved><innovate><innovation><innovative><insight><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><preparations><process optimization><programs><real world application><screening><screenings><skills><social role><speech recognition><supervised learning><supervised machine learning><tool><transition metal><wasting>
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TERENCE S. DERMODY

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 24/100
Active award
Career award
$237,419
FY 2026

Project Title

Molecular Basis of Pediatric Disease

Grant Number:

5K12HD052892-19

Activity Code:

K12

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/10/2007

End Date:

11/30/2027

Project Abstract

This proposal requests continued Child Health Research Career Development Award (CHRCDA) support for the Molecular Basis of Pediatric Disease Training Program at the University of Pittsburgh and UPMC Children’s Hospital of Pittsburgh (CHP). The primary goal of the Molecular Basis of Pediatric Diseas...

Research Terms

<Award><Biomedical Research><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Child Health><Childhood><Children's Hospital><Dedications><Department chair><Disease><Disorder><Environment><Faculty><Fostering><Funding><Future><Goals><Grant><Individual><Investigators><K-Awards><K-Series Research Career Programs><Laboratories><Mentors><Molecular><NIH><National Institutes of Health><Outcome><Pediatric Hospitals><Pediatric Research><Physicians><Publications><R-Series Research Projects><R01 Mechanism><R01 Program><Reproducibility><Request for Proposals><Research><Research Career Program><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Resources><Scholars Program><Scientific Inquiry><Scientific Publication><Scientist><Secure><Talents><Training><Training Programs><United States National Institutes of Health><Universities><Writing><career><design><designing><experience><faculty mentor><full professor><high standard><improved><innovate><innovation><innovative><pediatric><pediatric department><peer coaching><peer instruction><peer led team learning><peer mentoring><peer teaching><programs><senior faculty><sq. ft><square foot><training opportunity>
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Pranita Tamma

CHILDREN'S HOSP OF PHILADELPHIA, PHILADELPHIA, PA

Exploratory lead · 24/100
Active award
Career award
$204,153
FY 2026

Project Title

Advancing Mentorship at the Johns Hopkins Integrated Center for Combating Antimicrobial Resistant Bacteria

Grant Number:

7K24AI185302-02

Activity Code:

K24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/24/2025

End Date:

12/31/2029

Project Abstract

Project Summary I am passionate about identifying novel approaches to treating antimicrobial resistant (AMR) infections in children and adults. During my Pediatric Infectious Diseases fellowship, I completed a Masters in Clinical Investigations that enabled me to lead pivotal studies to move the fie...

Research Terms

<0-11 years old><21+ years old><Adult><Adult Human><Advisory Committees><Amino Acid Substitution><Amino Acids><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Antimicrobial Resistance><Award><Bacteria resistance><Bacteria resistant><Bacterial Genome><Bacterial resistant><Bactrim><Beta-Lactam resistant><Bioinformatics><Blood Plasma><CTX><CYCLO-cell><Cancers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Carloxan><Cefepime><Ceftazidime><Centrin><Child><Child Youth><Childhood><Children (0-21)><Ciclofosfamida><Ciclofosfamide><Cicloxal><Clafen><Claphene><Clinical><Clinical Data><Communicable Diseases><Cotrim><Cycloblastin><Cycloblastine><Cyclophospham><Cyclophosphamide><Cyclophosphamidum><Cyclophosphan><Cyclophosphane><Cyclophosphanum><Cyclostin><Cyclostine><Cytophosphan><Cytophosphane><Cytoxan><DNA mutation><Data Sources><Development><Diagnosis><Doctor of Philosophy><Dose><Drug Exposure><E coli><E. coli><Electronics><Endoxan><Endoxana><Enduxan><Ensure><Enzyme Gene><Enzymes><Escherichia coli><Eslectin><Exhibits><Fe element><Fellowship><Fellowship Program><Fiber><Fosfaseron><Funding><Future><G24 protein><Generalized Growth><Genetic Change><Genetic defect><Genetic mutation><Genome><Genoxal><Genuxal><Growth><Guidelines><Infection><Infectious Diseases><Infectious Disorder><Infusion><Infusion procedures><Insozalin><International><Iron><K-Awards><K-Series Research Career Programs><K23 Award><K23 Mechanism><K23 Program><Knowledge><Laboratories><Lead><Learning><Ledoxina><Letters><MD students><Malignant Neoplasms><Malignant Tumor><Medical><Medical Students><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Mentors><Mentorship><Meropenem><Methodology><Methods><Miscellaneous Antibiotic><Mitoxan><Modeling><Molecular><Molecular Modeling Nucleic Acid Biochemistry><Molecular Modeling Protein/Amino Acid Biochemistry><Molecular Models><Mutation><Neosar><Operative Procedures><Operative Surgical Procedures><P aeruginosa><P. aeruginosa><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Pb element><Persons><Ph.D.><PhD><Pharmacies><Pharmacodynamics><Pharmacy Students><Pharmacy facility><Piperacillin-Tazobactam><Plasma><Plasma Serum><Predisposition><Procytox><Pseudomonas aeruginosa><Pseudomonas maltophilia><Pseudomonas pyocyanea><Receptor Protein><Regimen><Research><Research Career Program><Resistance><Reticuloendothelial System, Serum, Plasma><Role><S maltophilia><S. maltophilia><SMZ-TMP><Science><Scientist><Sendoxan><Site><Societies><Stenotrophomonas maltophilia><Surgical><Surgical Interventions><Surgical Procedure><Susceptibility><Syklofosfamid><TMP-SMX><Task Forces><Tazobactam><Tazocel><Tazocin><Test Result><Tissue Growth><Training><Treatment Period><Trimedin><Trimethoprim-Sulfamethoxazole><Trimezole><Visualization><Work><Xanthomonas maltophilia><Zosyn><Zytoxan><adulthood><advisory team><aminoacid><anti-microbial resistant><anti-microbial resistant infection><antimicrobial resistant infection><b lactam resistance><b-lactam resistant><bacterial resistance><beta lactam antibiotic><beta lactam hydrolase><beta-Lactam Resistance><beta-Lactamase><beta-Lactamhydrolase><beta-Lactams><biobank><biorepository><carbapenem resistance><carbapenem resistant><cefepim><clinical applicability><clinical application><clinical investigation><clinical relevance><clinically relevant><comparative effectiveness study><design><designing><developmental><dosage><effective therapy><effective treatment><efflux pump><electronic><electronic device><genome mutation><graduate student><heavy metal Pb><heavy metal lead><improved><infusions><kids><malignancy><medical school students><molecular biomarker><molecular marker><molecular modeling><mortality><mutant><neoplasm/cancer><new approaches><next generation><novel approaches><novel strategies><novel strategy><ontogeny><optimal therapies><optimal treatments><pathway><patient oriented outcomes><pediatric><professor><receptor><resistance against beta lactams><resistance against carbapenems><resistance gene><resistance locus><resistance mechanism><resistance mutation><resistance to Bacteria><resistance to Bacterial><resistance to anti-microbial><resistance to b lactam><resistance to beta-lactam><resistance to carbapenem><resistance to β-Lactam><resistant><resistant gene><resistant mechanism><resistant mutation><resistant to Bacteria><resistant to Bacterial><resistant to antimicrobial><resistant to b lactam><resistant to beta-lactam><resistant to carbapenem><resistant to β-Lactam><skills><social role><surgery><treatment days><treatment duration><youngster><β lactam antibiotic><β-Lactam Resistance><β-Lactam resistant><β-Lactamase><β-Lactams>
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WILLIAM M GEISLER

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Exploratory lead · 24/100
Active award
Career award
$151,812
FY 2026

Project Title

Midcareer Mentoring Award for Patient-Oriented Research in Chlamydia trachomatis Infection

Grant Number:

5K24AI125685-09

Activity Code:

K24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/1/2016

End Date:

10/31/2027

Project Abstract

Modified Project Summary/Abstract Section This application is for a renewal of my K24 Midcareer Investigator Award in Patient-Oriented Research (POR) on Chlamydia trachomatis (CT) Infections. I, Dr. William Geisler, am a federally funded physician scientist at the University of Alabama at Birmingham...

Research Terms

<16 year old><16 years of age><18 year old><18 years of age><A vaginae><A. vaginae><Address><Adolescent><Adolescent Youth><Affect><Alabama><Antibodies><Antigens><Area><Atopobium vaginae><Award><Biological Markers><Blood><Blood Reticuloendothelial System><Blood Serum><C trachomatis><C. trachomatis><Chlamydia><Chlamydia trachomatis><Clinic><Clinical Investigator><DNA><Deoxyribonucleic Acid><Development><Disparities><Disparity><Doctor of Medicine><ELISA><Education><Educational aspects><Educational process of instructing><Enrollment><Entrepreneurial Skill><Entrepreneurship><Enzyme-Linked Immunosorbent Assay><Female><Frequencies><Funding><Genital Organs><Genitalia><Goals><Gynecology><HIV risk><HLA-DC><HLA-DC Antigens><HLA-DQ><HLA-DQ Antigens><HLA-DQB1><HLA-DQB1 antigen><HLA-DQbeta1><HLA-DS><HLA-DS Antigens><HLA-LB><HLA-LB Antigens><HLA-MB><HLA-MB Antigens><Health><IFN><Immunity><Immunogenetics><Infection><Infection Control><Infection prevention><Interferons><International><Interview><Investigators><K24 Award><K24 Mechanism><K24 Program><Knowledge><Leadership><Linkage Disequilibrium><M.D.><M.P.H.><Master of Public Health><Mediating><Mentors><Mentorship><MicroRNAs><Mid-Career Clinical Scientist Award (K24)><Midcareer Investigator Award in Patient-Oriented Research><Midcareer Investigator Award in Patient-Oriented Research (K24)><Miyagawanella><Mucosa><Mucosal Tissue><Mucous Membrane><NIH><National Institutes of Health><Patients><Physicians><Population><Position><Positioning Attribute><Prevent infection><Prevention><Public Health><Publications><R-Series Research Projects><R01 Mechanism><R01 Program><Reporting><Research><Research Activity><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Specimen><Researchers><Respondent><Rickettsia trachomae><Risk><Risk Marker><Scientific Publication><Scientist><Secure><Serum><Source><Specimen><Students><Survey Instrument><Surveys><Swab><T cell response><T-Cells><T-Lymphocyte><TL1><TNF Ligand-Related Molecule 1><TNF15><TNFSF15><TNFSF15 gene><Teaching><Testing><Time><Training><Translating><Tumor Necrosis Factor Ligand Superfamily Member 15><United States National Institutes of Health><Universities><VEGI><Vaccines><Variant><Variation><Vascular Endothelial Growth Inhibitor><Visit><Woman><access to vaccination><access to vaccines><age 16><age 16 years><age 18><age 18 years><antigen based test><antigen test><bedsonia><bench bed side><bench bedside><bench to bed side><bench to bedside><bench to clinic><bench to clinical practice><bio-markers><biologic marker><biomarker><career><career development><chlamydia vaccine><clinical practice><commercialization><design><designing><develop a vaccine><develop vaccines><development of a vaccine><developmental><early experience><eighteen year old><eighteen years of age><enroll><enzyme linked immunoassay><experience><immunogen><immunogenic><improved><infection rate><infection risk><insight><interest><juvenile><juvenile human><male><miRNA><patient oriented research><patient oriented study><patient population><perinatal morbidity><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><programs><public health relevance><rate of infection><recruit><reproductive><reproductive morbidity><research study><response><risk predictor><risk predictors><sample collection><screening><screenings><sixteen year old><sixteen years of age><skill acquisition><skill development><skills><specimen collection><success><thymus derived lymphocyte><vaccination access><vaccination availability><vaccine access><vaccine availability><vaccine candidate><vaccine development><young woman><♀><♂>
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Jeong H Yun

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 22/100
Recent
Active award
$120,825
FY 2026

Project Title

Early Immune Signatures of COPD: Linking Inflammation to Disease Progression

Grant Number:

1R03HL183108-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

12/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT The R03 application builds upon Dr. Yun’s K08-funded study, which investigated how hedgehog interacting protein (HHIP) deficiency contributes to lymphocytic inflammation in chronic obstructive pulmonary disease (COPD). Through that work, we identified unique CD8+T cell popul...

Research Terms

<Active Follow-up><Address><Age><Airway Disease><Airway Resistance><Amino Acid Sequence Determinations><Antigens><Autoimmune><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Award><Blood><Blood Reticuloendothelial System><CD8><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CD8B><CD8B1><CD8B1 gene><COPD><Cell Aging><Cell Body><Cell Communication and Signaling><Cell Senescence><Cell Signaling><Cell secretion><Cells><Cellular Aging><Cellular Secretion><Cellular Senescence><Chronic><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clinical><Clonality><Data><Data Set><Development><Disease><Disease Progression><Disorder><Ectopic lymphoid organ><Ectopic lymphoid structure><Emphysema><Erinaceidae><Expression Signature><Foundations><Funding><Future><GWA study><GWAS><Gene Expression Profile><Genes><Genetic><Genomics><Hedgehogs><Human><IFN-Gamma><IFN-g><IFN-γ><IFNG><IFNγ><Immune><Immune Interferon><Immunes><Inflammation><Inflammatory><Interferon Gamma><Interferon Type II><Intracellular Communication and Signaling><K Cells><Killer Cells><LYT3><Lectin><Link><Long-term cohort><Longitudinal cohort><Lung><Lung Diseases><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Lymphatic cell><Lymphocyte><Lymphocytic><Lymphocytic Infiltrate><Lymphoid><MHC Receptor><Major Histocompatibility Complex Receptor><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Memory><Mice><Mice Mammals><Micro Array Data><Modeling><Modern Man><Murine><Mus><Non-Polyadenylated RNA><Onset of illness><Outcome><PBMC><Participant><Pathogenesis><Pathologic Processes><Pathological Processes><Pathology><Patients><Peptide Sequence Determination><Peripheral Blood Mononuclear Cell><Play><Population><Property><Protein Deficiency><Protein Sequence Determinations><Protein Sequencing><Protein Sequencing Molecular Biology><Proteins><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Emphysema><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Receptor Protein><Replicative Senescence><Ribonucleic Acid><Role><Sampling><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Structure of parenchyma of lung><Surface Proteins><T cell infiltration><T cell receptor repertoire sequencing><T cell receptor sequencing><T-Cell Antigen Receptors><T-Cell Receptor><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Subsets><T-cell receptor repertoire><T8 Cells><T8 Lymphocytes><TCR repertoire><TCR repertoire sequencing><TCR sequencing><TCR-seq><TCRseq><Tertiary lymphoid structure><Testing><Time><Work><active followup><ages><autoimmune condition><autoimmune disorder><autoimmunity disease><biological signal transduction><cease smoking><chronic obstructive pulmonary disorder><cigarette smoke exposure><cohort><cytokine><cytotoxic><deficiency of protein><developmental><disease of the lung><disease onset><disorder of the lung><disorder onset><emphysematous><exposure to cigarette smoke><follow up><follow-up><followed up><followup><gene expression pattern><gene expression signature><gene signatures><genetic signature><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><immunogen><insight><lFN-Gamma><lung disorder><lung function decline><lymph cell><mouse model><murine model><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><prevent><preventing><pulmonary function decline><quit smoking><receptor><replicative aging><response><risk stratification><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell technology><single cell transcriptomic profiling><single-cell RNA sequencing><smoking cessation><social role><stop smoking><stratify risk><tertiary lymphoid organ><therapeutic agent development><therapeutic development><therapeutic target><thymus derived lymphocyte><transcriptional profile><transcriptional signature><transcriptome sequencing><transcriptomic sequencing><transcriptomics><whole genome association analysis><whole genome association study>
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ROBERT N WEINREB

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 18/100
Active award
Career award
$1
FY 2025

Project Title

Ophthalmology and Visual Sciences Career Development K12 Program

Grant Number:

5K12EY024225-10

Activity Code:

K12

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2015

End Date:

7/31/2026

Project Abstract

PROJECT SUMMARY / ABSTRACT The overall objective of the NEI Mentored Clinical Scientist Development Program Award at UCSD is to develop outstanding clinician scientists to successfully compete for NIH grants and emerge as leaders within academic ophthalmology. Through this institutional career devel...

Research Terms

<AI system><Appointment><Area><Artificial Intelligence><Award><Basic Research><Basic Science><Biomedical Engineering><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Childhood><Clinical><Clinical Sciences><Computer Reasoning><Curriculum><Department chair><Education><Educational Curriculum><Educational aspects><Ethics><Eye><Eyeball><Fellowship><Funding><Genomics><Glaucoma><Goals><Grant><Individual><Informatics><Institution><K-Awards><K-Series Research Career Programs><K12><K12 Award><K12 Mechanism><K12 Program><Lead><Leadership><Machine Intelligence><Mentored Clinical Scientist Development Program><Mentors><Minority><NIH><National Institutes of Health><Ophthalmology><Pb element><Preparation><Proteomics><Research><Research Career Program><Residencies><Retina><Scientist><Structure><Training><United States National Institutes of Health><Woman><Writing><bio-engineered><bio-engineers><bioengineering><biological engineering><career><career development><clinical relevance><clinically relevant><ethical><glaucomatous><heavy metal Pb><heavy metal lead><human subject><lesson plans><next generation><pediatric><preparations><progenitor biology><progenitor cell biology><programs><recruit><responsible research conduct><skills><statistics><stem and progenitor biology><stem cell biology><vision science><visual neuroscience><visual science>
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Kim Hung Ho Liss

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 16/100
Active award
$116,625
FY 2026

Project Title

Novel Use of Fomepizole in Hepatic Ischemia Reperfusion Injury

Grant Number:

1R03DK145778-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT The demand for liver transplantation far exceeds the number of suitable donor organs. Despite the organ shortage, due to increased risk for ischemia reperfusion injury (IRI), many marginal donor livers with steatosis go unused. While some IRI is unavoidable in all liver oper...

Research Terms

<1,2-Ethanediol><2-Hydroxyethanol><4-Nitrophenol-2-Hydroxylase><4-methylpyrazole><ALT1><APAP><APAP hepatotoxicity><APAP-induced liver injury><Acetamidophenol><Acetaminophen><Acetominophen><Address><Alanine Aminotransferase><Alanine Transaminase><Alanine-2-Oxoglutarate Aminotransferase><Alcohol dehydrogenase><Alcohol-NAD+ Oxidoreductase><Allografting><Attenuated><Blood flow><C-jun Amino-Terminal Kinase><C-jun Kinase-1><C-jun N-Terminal Kinase 1><CPE1><CYP 2E1><CYP IIE1><CYP2E><CYP2E1><CYP2E1 gene><CYPE1><CYPIIE1><Case Study><Case-Base Studies><Cell Death><Cellular injury><Cessation of life><Clinical><Collaborations><Common Rat Strains><Cryofixation><Cryopreservation><Cytochrome P-450 CYP2E1><Cytochrome P-450 IIE1><Cytochrome P-450-J><Cytochrome P450 2E1><Cytochrome P450, Family 2, Subfamily E, Polypeptide 1><Cytochrome P450, subfamily Ethanol-Inducible, Polypeptide 1><Data><Death><Development><Dihydroxyethanes><Dimethylnitrosamine N-Demethylase><Drug Therapy><Drug usage><Dysfunction><Elderly><Ethanediols><Ethanol-Inducible P450><Ethylene Glycols><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Fats><Fatty acid glycerol esters><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Functional disorder><Funding Mechanisms><Glutamic-Alanine Transaminase><Glutamic-Pyruvate Transaminase><Glutamic-Pyruvic Transaminase><Goals><Hepatic Disorder><Hepatic Transplantation><Hepatology><Hepatotoxic effect><Hepatotoxicity><Histologic><Histologically><Hydroxyacetanilide><Hypothermia><In Vitro><Inflammation><Inflammatory Response><Injury><Injury to Liver><Interruption><Ischemia><Ischemia-Reperfusion Injury><Isolated Perfusion><Isolation Perfusion><Isolation Perfusion Therapy><JN Kinase><JNK><JNK Mitogen-Activated Protein Kinases><JNK1><JNK1 Kinase><JNK1 protein><JNK1A2><JNK21B1/2><Kinases><Learning><Lipids><Liver><Liver Grafting><Liver Toxicity><Liver Transplant><Liver diseases><MAP Kinase 8><MAP Kinase 8 Gene><MAPK8><MAPK8 Mitogen-Activated Protein Kinase><MAPK8 gene><Metabolic dysfunction><Metabolic stress><Mitogen-Activated Protein Kinase 8><Modeling><Molecular><Monoethylene Glycol><Morbidity><N-Nitrosodimethylamine Demethylase><N-terminal><NH2-terminal><Obesity><Organ><Organ Donor><Organ Preservation><Outcome><Oxidative Stress><P450-2E1><P450-J><P450C2E><PRKM8><Paracetamol><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Perfusion><Pharmacological Treatment><Pharmacotherapy><Phase><Phosphotransferase Gene><Phosphotransferases><Physiopathology><Poisoning><Predisposition><Preservation Technique><Prevalence><Property><Rat><Rats Mammals><Rattus><Regional Perfusion><Reperfusion Damage><Reperfusion Injury><Reperfusion Therapy><Research Proposals><Risk><Role><SAP Kinase-1><SAPK/JNK><SAPK1 Mitogen-Activated Protein Kinase><SAPK1/JNK><Sterility><Stress-Activated Protein Kinase JNK1><Stress-Activated Protein Kinase gamma><Subfamily Ethanol-Inducible Cytochrome P450><Subfamily IIE Cytochrome P450><Susceptibility><System><Techniques><Testing><Therapeutic><Time><Toxic effect on liver cells><Traction><Transphosphorylases><Transplantation><Vascular blood supply><Waiting Lists><acetaminophen hepatotoxicity><acetaminophen poisoning><acetaminophen-induced liver injury><adiposity><advanced age><allograft rejection><attenuate><attenuates><blood supply><c-jun N-Terminal Kinase><case report><cell damage><cell injury><cellular damage><cold preservation><cold storage><compound repositioning><compound repurposing><corpulence><cost><cost effective><damage to cells><design><designing><determine efficacy><develop therapy><developmental><drug intervention><drug repositioning><drug repurposing><drug treatment><drug use><effectiveness testing><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><ethylene glycol><evaluate efficacy><examine efficacy><fomepizole><geriatric><graft function><hepatic body system><hepatic damage><hepatic disease><hepatic injury><hepatic ischemia><hepatic organ system><hepatic toxicity><hepatopathy><hepatoxicity><improved><in vivo><inhibitor><injuries><injury to cells><innovate><innovation><innovative><intervention development><jun-NH2-Terminal Kinase><liver damage><liver disorder><liver injury><liver ischemia><liver preservation><liver transplantation><methanol poisoning><mitochondrial dysfunction><mortality><natural hypothermia><necrocytosis><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic uses for existing drugs><new therapeutics><new therapy><new use of drug><new uses for an approved drug><new uses for existing drugs><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><operation><operations><pathophysiology><pathway><patient oriented outcomes><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological repurposing><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><poisoned><pre-clinical study><preclinical study><prevent><preventing><reperfusion><repositioning approved drugs><repositioning existing drugs><repurpose approved drugs><repurpose approved medication><repurpose approved therapeutic><repurpose existing drugs><repurpose existing medication><repurpose existing medicine><repurpose existing therapeutics><repurpose existing therapies><repurpose medicine><repurposing><repurposing a drug><repurposing agent><repurposing candidates><repurposing established drugs><repurposing established medication><repurposing existing pharmacological agents><repurposing medication><repurposing of already existing drugs><repurposing pharmaceuticals><response><senior citizen><social role><sterile><stress-activated protein kinase 1><therapeutic evaluation><therapeutic repositioning><therapeutic repurposing><therapeutic testing><therapy development><transplant><treatment development><vascular supply><waitlist>
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Hojun Li

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 10/100
Active award
$239,213
FY 2025

Project Title

The interface between glucocorticoid signaling and histone acetylation in erythropoiesis

Grant Number:

1R03DK144353-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Chronic glucocorticoid therapy is a mainstay of treatment for Diamond-Blackfan anemia (DBA), but leads to a number of toxicities including, but not limited to, gastric ulcers, immunosuppression, hyperglycemia, renal dysfunction, steatosis, adrenal suppression, hypertension, ...

Research Terms

<Acetylation><Active Follow-up><Adrenal Glands><Adrenals><Affect><Alloimmunization><Anemia><Award><Biological><Biology><Blood erythrocyte><CRISPR><CRISPR/Cas system><Career Mobility><Cataract><Cell Communication and Signaling><Cell Signaling><ChIP assay><Chronic><Clinical><Clinical Trials><Closure by Ligation><Clustered Regularly Interspaced Short Palindromic Repeats><Co-Immunoprecipitations><Cytokine Receptors><Data><Development><Diamond-Blackfan anemia><Differentiated Gene><Drug usage><Drugs><E1A Binding Protein p300><EP300><EP300 gene><EPOR><EPOR gene><ERYF1><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Erythroblasts><Erythrocyte Count><Erythrocyte Measurement><Erythrocyte Number><Erythrocytes><Erythrocytic><Erythroid><Erythroid Cells><Erythroid Precursor Cells><Erythroid Progenitor Cells><Erythroid Stem Cells><Erythropoiesis><Erythropoietic Progenitor Cells><Erythropoietic Stem Cells><Erythropoietin Receptor Gene><Fe overload><Funding><Future><GATA Binding Protein 1><GATA-1><GATA1><GATA1 gene><GATA1 protein><GATA1 transcription factor><GF-1 protein><Gastric ulcer><Gene Activation><Gene Targeting><Gene Transcription><Genes><Genetic Transcription><Genomics><Glucocorticoid Receptor><Glucocorticoids><Goals><GvHD><HSC transplantation><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Histone Acetylase><Histone Acetylation><Histone H3><Homologous Wasting Disease><Human><Hyperglycemia><Hypertension><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Impairment><Individual><Infection><Intervention><Intracellular Communication and Signaling><Investigation><Iron Overload><KAT3B><Knock-out><Knockout><L-Lysine><Lead><Ligation><Link><Lysine><Marrow erythrocyte><Medication><Modality><Modeling><Modern Man><Molecular><NF-E1 erythroid-specific transcription factor><NFE1 protein><Normoblasts><Nucleated Erythrocytes><Nucleated red blood cell><Nucleated red cell><Osteoporosis><Outcome><Output><Patients><Pb element><Pharmaceutical Preparations><Phenocopy><Principal Investigator><Production><Progenitor Cell Transplantation><Proliferating><Public Health><QOL><Quality of life><RNA Expression><Receptor Activation><Red Blood Cell Count><Red Blood Cells><Red Cell><Regulation><Repression><Research><Runt Disease><Safety><Signal Transduction><Signal Transduction Systems><Signaling><Speed><Stem Cell Transplantation><Stem cell transplant><Steroid Compound><Steroids><Stomach Ulcer><Testing><Therapeutic><Toxic effect><Toxicities><Transcript><Transcription><Transcription Factor GATA1><Transfusion><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><active followup><biologic><biological signal transduction><blood corpuscles><blood stem cell transplantation><career advancement><career transition><cataractogenesis><cataractous lenses><cell type><chromatin immunoprecipitation><class development><conditioning><course development><course material development><death risk><developmental><drug use><drug/agent><epigenetically><erythroid development><erythroid differentiation><erythroid progenitor><erythroid-committed progenitors><experiment><experimental research><experimental study><experiments><follow up><follow-up><followed up><followup><frontier><globin transcription factor 1><graft versus host disease><graft vs host disease><graft vs. host disease><heavy metal Pb><heavy metal lead><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><high blood pressure><histone acetyltransferase><histone acetyltransferase p300><hyperglycemic><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><immune suppression><immune suppressive activity><immune suppressive function><immunosuppressive activity><immunosuppressive function><immunosuppressive response><improved><inhibitor><kidney dysfunction><mortality risk><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><nuclear factor-erythroid 1><nucleated RBCs><p300><pre-clinical development><pre-clinical evaluation><preclinical development><preclinical evaluation><progenitor cell differentiation><progenitor differentiation><progenitor transplantation><programs><proliferation capability><proliferation capacity><proliferation potential><proliferative capability><proliferative capacity><proliferative potential><renal dysfunction><replication therapy><small molecule><stem and progenitor cell transplantations><stem and progenitor differentiation><stem cell differentiation><suprarenal gland><synergism><systemic toxicity><transcription factor NFE-1>
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Won Jae Huh

YALE UNIVERSITY, NEW HAVEN, CT

Exploratory lead · 10/100
Active award
$125,625
FY 2025

Project Title

Sox4 Dependent Parietal Cell Plasticity in Gastric Ulcer

Grant Number:

5R03DK137013-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/6/2024

End Date:

7/31/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT Gastric ulcer is increasing in the United States due to increasing use of non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori infection. It has been a major cause of gastrointestinal surgery with high morbidity and mortality. While molecular and cellular m...

Research Terms

<Acids><Acute><Apoptosis><Apoptosis Pathway><Assay><Atrophic Gastritis><Award><Bioassay><Biological Assay><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Signaling><Cells><Chief Cell><Chronic><Chronic Atrophic Gastritis><Complement><Complement Proteins><Data><Development><Dysplasia><EGF Receptor><EGFR><ERBB Protein><EVI16><Ecotropic Viral Integration Site 16><Epidermal Growth Factor Receptor><Epidermal Growth Factor Receptor Kinase><Epidermal Growth Factor Receptor Protein-Tyrosine Kinase><Epidermal Growth Factor-Urogastrone Receptors><Epithelial Cells><Epithelium><Fluorescence Activated Cell Sorting Fractionation><Fluorescence-Activated Cell Sorting><Fluorescence-Activated Cell Sortings><Foundations><Funding><Future><Gastric Adenocarcinoma><Gastric Parietal Cells><Gastric mucosa><Gastric ulcer><Gastrointestinal Surgical Procedures><Genes><Giant Hypertrophic Gastritis><Goals><Grant><H pylori infection><H. pylori infection><HER1><Helicobacter Infections><Helicobacter Pylori Infection><Hypertrophic Gastritis><Immunofluorescence Microscopy><Inflammation><Injury><Intracellular Communication and Signaling><Knock-out><Knockout><Knowledge><Label><Lesion><Lineage Tracing><Location><Menetrier Disease><Metaplasia><Metaplastic Change><Microscopic><Molecular><Morbidity><Morbidity - disease rate><Mucosa><Mucosal Tissue><Mucous Membrane><Muscularis Mucosa><Ménétrier's disease><NIDDK><NSAIDs><National Institute of Diabetes and Digestive and Kidney Diseases><Natural regeneration><Non-Steroidal Anti-Inflammatory Agents><Oncogenesis><Oncogenic><Organoids><Oxyntic Cells><Parietal Cell><Play><Process><Progenitor Cells><Programmed Cell Death><Proteins><Receptor Signaling><Regeneration><Reporting><Research><Reserve Stem Cell><Role><SOX4><SOX4 gene><SPEM polypeptide><SRY-Box 4><SRY-Related HMG-Box Gene 4><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Sorting><Stem Cell like><Stomach><Stomach Adenocarcinoma><Stomach Ulcer><TGF-alpha Receptor><Testing><Thick><Thickness><Transfection><Transforming Growth Factor alpha Receptor><Ulcer><Ulceration><United States><Urogastrone Receptor><biological signal transduction><c-erbB-1><c-erbB-1 Protein><cancer progression><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular differentiation><cellular lineage mapping><cellular lineage tracking><complementation><design><designing><develop therapy><developmental><dyscrasia><effective therapy><effective treatment><epithelium regeneration><erbB-1><erbB-1 Proto-Oncogene Protein><erbBl><gastric><gastric atrophy><gastric progenitor><gastric stem cell><gastric tumorigenesis><gastrointestinal surgery><healing><injuries><injury and repair><intervention development><mortality><mouse model><murine model><mutant><neoplasm progression><neoplastic><neoplastic progression><non-steroidal anti-inflammatory drugs><novel><operative procedure on the gastrointestinal system><overexpress><overexpression><precancer><precancerous><premalignant><prevent><preventing><progenitor capacity><progenitor cell like><progenitor cell maintenance><progenitor maintenance><progenitor-like><programs><proto-oncogene protein c-erbB-1><regenerate><regenerate epithelium><repair><repaired><reserve progenitor><reserve stem and progenitor cell><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell analysis><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><spasmolytic polypeptide><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><stem cell characteristics><stem cell maintenance><stem cells><stem-like><stemness><stomach progenitor><stomach stem cell><stomach tumorigenesis><therapy development><transdifferentiation><treatment development><tumor progression><tumorigenesis>
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Jason Philip Van Batavia

CHILDREN'S HOSP OF PHILADELPHIA, PHILADELPHIA, PA

Exploratory lead · 0/100
$133,500
FY 2025

Project Title

Bladder Voiding After Stress Defeat Stress: Impact of Sex and Gonadal Hormones

Grant Number:

5R03DK139286-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

4/30/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT Lower urinary tract symptoms (LUTS) and disorders of voiding are among the most common reasons for referral to the urologist and affect ~20% of school-aged children. LUTS can be caused by one of several different LUT conditions, including voiding postponement, and the preval...

Research Terms

<0-11 years old><21+ years old><ACTH-Releasing Factor><Abscission><Adult><Adult Human><Affect><Age><Animal Model><Animal Models and Related Studies><Anxiety><Basic Research><Basic Science><Behavioral Assay><Birth><Bladder><Bladder Urinary System><Bladder outlet obstruction><Brain><Brain Nervous System><Brain Stem><Brain region><Brainstem><CRF Receptors><CRF receptor type 1><CRF-41><CRF-R1><CRF1 receptor><CRH Receptors><CRH-1><Causality><Cell Nucleus><Child><Child Youth><Children (0-21)><Chronic><Clinical><Clinical Sciences><Collaborations><Communication><Corticoliberin><Corticosterone><Corticotropin Releasing-Factor Receptors><Corticotropin-Releasing Factor><Corticotropin-Releasing Factor-41><Corticotropin-Releasing Hormone><Corticotropin-Releasing Hormone Receptors><Corticotropin-Releasing Hormone-41><Crh1 receptor><Data><Development><Diagnosis><Differences between sexes><Differs between sexes><Disease><Disorder><Dysfunction><Encephalon><Endocrine Gland Secretion><Ensure><Estrogen Receptors><Etiology><Excision><Exposure to><Extirpation><FISH Technic><FISH Technique><FISH analysis><FISH assay><Feeling><Female><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><Functional disorder><Future><Generalized Growth><Gonadal Hormones><Gonadal Steroid Hormones><Grant><Growth><HPA axis><Histology><Hormones><Knowledge><Laboratories><Link><Lower urinary tract><Measures><Mental Depression><Mental disorders><Mental health disorders><Mentors><Mice><Mice Mammals><Modeling><Murine><Mus><Muscle><Muscle Tissue><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurohormones><Neurons><Neuropeptides><Non-Polyadenylated RNA><Nucleus><Outcome><Overactive Bladder><Parturition><Pattern><Phenotype><Physiopathology><Population><Predisposition><Prevalence><Prevention><Psychiatric Disease><Psychiatric Disorder><Psychologic Stress><Psychological Stress><Psychosocial Factor><Psychosocial Stress><Publishing><QOL><Quality of life><RNA><RNA Gene Products><Receptor Protein><Removal><Research><Ribonucleic Acid><Rodent><Rodentia><Rodents Mammals><Role><School-Age Population><Schools><Sex Differences><Sex Hormones><Sex Steroid Hormones><Sexual differences><Stress><Surgical Removal><Susceptibility><Symptoms><Testing><Therapeutic Hormone><Tissue Growth><Urination><Urologist><Urology><Work><adult youth><adulthood><ages><alleviate symptom><ameliorating symptom><bully><bullying><causation><co-morbid><co-morbidity><comorbidity><corticotropin releasing hormone><corticotropin-releasing factor receptor 1><decrease symptom><depression><desensitization><developmental><disease causation><feelings><fewer symptoms><gonadal steroids><hormonal signals><hormone signals><hypothalamic-pituitary-adrenal (HPA) axis><hypothalamic-pituitary-adrenal axis><hypothalmus-pituitary-adrenal axis><improved><kids><lower urinary tract symptoms><male><mental illness><micturition><model of animal><muscular><neuronal><neuropsychiatric><neuropsychiatry><novel><ontogeny><optogenetics><pathophysiology><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><psychiatric illness><psychological disorder><psychosocial stresses><psychosocial stressors><psychosocial variables><receptor><receptor expression><reduce symptoms><relieves symptoms><resection><resilience><resilient><response><school age><sex><sex based differences><sex dimorphism><sex related variation><sex steroid><sex variable><sex variation><sex-dependent differences><sex-related differences><sex-related variable><sex-specific differences><sexual dimorphism><sexually dimorphic><skills><social defeat><social role><social stress><socially stressed><stem><symptom alleviation><symptom reduction><symptom relief><urinary bladder><varies by sex><young adult><young adult age><young adulthood><youngster><♀><♂>
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John W Evankovich

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 0/100
$118,070
FY 2025

Project Title

Fibronectin Extra Domain A Degradation as an Antifibrotic Approach in Lung Fibrosis

Grant Number:

5R03HL173071-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2026

Project Abstract

ABSTRACT This application is for an NHLBI R03 Small Grant Award for K08 Recipients entitled “Fibronectin Extra Domain A Degradation as an Antifibrotic Approach in Lung Fibrosis.” I am a physician in Pulmonary and Critical Care Medicine at the University of Pittsburgh, and I am building a research pr...

Research Terms

<APF-1><ATP-Dependent Proteolysis Factor 1><Allergy><Alternate Splicing><Alternative RNA Splicing><Alternative Splicing><Assay><Attenuated><Automobile Driving><Award><Back><Binding><Bioassay><Biological Assay><Bleo><Bleomycin><Bone-Derived Transforming Growth Factor><CAR T cells><CAR modified T cells><CAR-T><CAR-Ts><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell surface><Cell-Extracellular Matrix><Cells><Chronic><Clinical><Cold-Insoluble Globulins><Collagen><Critical Care><Data><Defect><Degradation Pathway><Degradative Pathway><Deposit><Deposition><Development><Diagnosis><Disease><Disorder><Dorsum><Drug Therapy><Drugs><ECM><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Endosomes><Extracellular Matrix><Extracellular Matrix Degradation><Extracellular Matrix Proteins><FN1><FTI><Farnesyl Transferase Inhibitor><Farnesyltransferase Inhibitors><Fibroblasts><Fibronectin 1><Fibronectins><Fibrosing Alveolitis><Fibrosis><Glycoprotein GP-2><Glycoproteins><Grant><Growth Agents><Growth Factor><Growth Substances><HMG-20><Half-Life><High Mobility Protein 20><High Throughput Assay><Human><Immune><Immunes><Immunologic Receptors><Immunological Receptors><In Vitro><Inflammatory><Integrins><Integrins Extracellular Matrix><Interstitial Lung Diseases><Intracellular Communication and Signaling><Investigation><Isoforms><KO mice><Knock-out Mice><Knockout Mice><LETS Proteins><Laminin><Large External Transformation-Sensitive Protein><Learning><Ligands><Lonafarnib><Lung><Lung Diseases><Lung Respiratory System><Lung Tissue Fibrosis><Lysosomes><Medication><Medicine><Metabolic Protein Degradation><Methodology><Milk Growth Factor><Modeling><Modern Man><Molecular><Molecular Interaction><Morbidity><Morbidity - disease rate><Myofibroblast><NHLBI><National Heart, Lung, and Blood Institute><Null Mouse><O element><O2 element><Opsonic Glycoprotein><Opsonic alpha(2)SB Glycoprotein><Oxygen><Pathogenesis><Pathologic><Pathway interactions><Patients><Pattern><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Physicians><Platelet Transforming Growth Factor><Pre-Clinical Model><Preclinical Models><Property><Protein Farnesyltransferase Inhibitors><Protein Isoforms><Protein Turnover><Proteins><Proteins Growth Factors><Publishing><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Fibrosis><RNA Splicing><Receptor Protein><Receptosomes><Recycling><Regulatory Protein Degradation><Reporting><Research><Sarasar><Scaffolding Protein><Scientist><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Site><Slice><Splicing><Supportive Therapy><Supportive care><System><Systemic Scleroderma><Systemic Sclerosis><T cells for CAR><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><TLR protein><Testing><Time><Toll-Like Receptor Family Gene><Toll-like receptors><Training><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Ubiquitilation><Ubiquitin><Ubiquitination><Ubiquitinoylation><Universities><Variant><Variation><Work><alpha 2-Surface Binding Glycoprotein><attenuate><attenuates><biological signal transduction><burden of disease><burden of illness><cell type><chimeric antigen T cell receptor><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cells><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><developmental><diffuse interstitial pulmonary fibrosis><disease burden><disease of the lung><disorder of the lung><driving><drug intervention><drug repositioning><drug repurposing><drug treatment><drug/agent><druggable target><effective therapy><effective treatment><fibrosis in the lung><fibrotic lung disease><fibrotic pulmonary disease><high throughput screening><idiopathic pulmonary fibrosis><immune receptor><in vivo><insight><interstitial><lung disorder><lung fibrosis><mortality><mouse model><murine model><new approaches><novel><novel approaches><novel strategies><novel strategy><pathway><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><polypeptide><prevent><preventing><programs><progressive systemic sclerosis><protein degradation><pulmonary><receptor><repurposing agent><repurposing medication><response><trafficking><ubiquination><ubiquitin conjugation>
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Search NIH grants by PI name

Looking for a specific principal investigator? The keyword search above looks up funded projects by topic. To search NIH grants by PI name (last name, first + last name, or partial name) and see every active and recent NIH award for that researcher, use the dedicated PI Funding Status tool.

How to Use PI Funding Data for Career Decisions

Finding the right principal investigator is one of the most important decisions in an academic career. Whether you are a postdoc looking for a mentor, a graduate student choosing a rotation lab, or a collaborator seeking a co-PI, NIH funding data provides objective signals about which investigators have active research programs and resources to support new team members.

A PI with a recently awarded R01 or equivalent grant is more likely to have budget for new personnel than one whose funding ended two years ago. The activity code tells you the type of grant: R01 and R35 awards typically support multiple lab members, while K-series awards are individual career development grants that may not fund additional positions. Understanding these distinctions helps you interpret search results accurately.

Look beyond the dollar amount. A $500,000 per year R01 at a high-cost institution may support fewer positions than a $300,000 award at a university with lower overhead rates. The project abstract and public health relevance statement reveal whether the PI's research direction aligns with your interests and expertise.

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A PI's grant portfolio reveals more than individual awards. Investigators with multiple active grants often run larger labs with more diverse projects, which can mean more opportunities for trainees. However, a PI with a single well-funded grant may offer more focused mentorship and a clearer path to publications.

Multi-PI grants (those with more than one principal investigator listed) indicate collaborative research and may involve trainees from multiple institutions. These can be excellent opportunities for interdisciplinary training but may also mean split attention from any single mentor.

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Frequently Asked Questions About PI Search

What does the opportunity score mean?

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Data limits

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For details on source coverage and refresh cadence, read Data & Methodology.

Related guides

Companion guides for turning a PI search result into useful outreach or a job lead.

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A tactical job-search guide for identifying recently funded labs, judging fit, and timing outreach to principal investigators.

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Principal investigators who received NIH awards in the last 90 days, organized by research area. Use this as a starting point for postdoc searches, collaborator outreach, or competitor scans. Counts and labs refresh daily.

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