NIH Grant Search by PI — Funded Principal Investigator Finder

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Enter a research topic, disease, or technology to find principal investigators with NIH funding in that area. To look up a specific PI by name, use the PI Funding Status check.

Search Results

Found 201 principal investigators from 200 displayed projects for "K99/R00" (2021–2026)

Note: 4,850 projects matched but only the first 200 were analyzed. Try narrowing your search with a more specific term or selecting "Project title only".

Opportunity Digest

Heuristic scoring to help trainees and job seekers prioritize which labs to inspect first.

1

High-opportunity leads

2

Likely hiring signals

72

Training-friendly awards

32

Average opportunity score

This search skews toward fellowships and mentored awards. It may be better for trainee funding or sponsor identification than direct job hunting.

Filter for opportunity type

Xingjun Fan

AUGUSTA UNIVERSITY, AUGUSTA, GA

High-opportunity lead · 82/100
Likely hiring
Above-average budget
Very recent
Active award
$615,995
FY 2026

Project Title

Center Core Grant for Vision Research

Grant Number:

2P30EY031631-06

Activity Code:

P30

Mechanism:

Research Centers

Agency:

NIH

Start Date:

9/1/2020

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary (Overall) This renewal application seeks continuing P30 funding for another five years to support the vision science research at the James and Jean Culver Vision Discovery Institute (VDI), Medical College of Georgia (MCG) of Augusta University (AU). Vision scientists at VDI engage in...

Research Terms

<Advanced Instrumentation><Animal Model><Animal Models and Related Studies><Award><Bioinformatics><Biometrics><Biometry><Biostatistics><Blindness><Body Tissues><Cell Body><Cells><Center Core Grants><Clinical><Collaborations><Common Rat Strains><Communities><Computer Instrumentation><Computers and Advanced Instrumentation><Core Grant><Data><Data Analyses><Data Analysis><Data Collection><Development><Doctor of Philosophy><Eligibility><Eligibility Determination><Ensure><Equipment><Experimental Therapies><Eye><Eyeball><Faculty><Faculty Recruitment><Funding><Grant><Histology><Human Resources><Image><Institution><International><Investigational Therapies><Investigational Treatments><Investigators><Laboratories><Manpower><Mice><Mice Mammals><Mission><Murine><Mus><Names><P30 Award><P30 Grant><P30 Mechanism><P30 Program><Patients><Ph.D.><PhD><Pilot Projects><Productivity><Protocol Screening><Qualifying><R-Series Research Projects><R01 Mechanism><R01 Program><Rat><Rats Mammals><Rattus><Research><Research Grants><Research Institute><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Resources><Scientist><Series><Services><Sight><Technology><Time><Tissues><Travel><Universities><Vision><Vision Disorders><Vision research><Visual Disorder><Work><clinical relevance><clinically relevant><collaborative approach><conference><convention><data interpretation><developmental><experience><experimental therapeutic agents><experimental therapeutics><imaging><innovative technologies><instrument><instrumentation><interest><investigator training><medical college><medical schools><member><model of animal><name><named><naming><next generation><novel><personnel><pilot study><programs><recruit><recruit teachers><school of medicine><service organization><success><summit><symposia><symposium><teacher recruitment><vision loss><vision science><visual function><visual loss><visual science>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Kathryn E Oliver

EMORY UNIVERSITY, ATLANTA, GA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$602,890
FY 2026

Project Title

Tuning translation efficiency to overcome refractory defects in CFTR

Grant Number:

5R01HL173500-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY (ABSTRACT) Approximately 100,000 people worldwide are living with cystic fibrosis (CF), a lethal autosomal recessive disorder caused by mutation of the CF transmembrane conductance regulator (CFTR). More than 2,100 disease-associated CFTR variants have been identified to date. Althou...

Research Terms

<25S rRNA><Address><Alleles><Allelomorphs><Anabolism><Animals><Antisense Agent><Antisense Oligonucleotides><Binding><Biochemical><Biochemistry><Biogenesis><Biological Chemistry><Body Tissues><C-terminal><CF airway epithelia><CF mice><CF mouse model><CFTR><CFTR Protein><Cell Body><Cell membrane><Cells><Chaperone><Clinical><Clinical Treatment><Colon><Complex><Computational Biology><Coupled><Cystic Fibrosis><Cystic Fibrosis Transmembrane Conductance Regulator><Cytoplasmic Membrane><DNA mutation><Data><Defect><Delta F508 mutation><Disease><Disorder><Environment><Exhibits><F344 Rats><F508 deletion><F508 mutation><F508-del><F508del><Fischer Rats><G-418><G418><GTP Phosphohydrolases><GTPases><Genetic><Genetic Change><Genetic Diseases><Genetic defect><Genetic mutation><Goals><Guanosine Triphosphate Phosphohydrolases><Guanosinetriphosphatases><Hereditary><Heterozygote><Human><In Vitro><Inbred CDF Rats><Inbred F344 Rats><Inbred Fischer 344 Rats><Inbred Fisher 344 Rats><Inhalation><Inhaling><Inherited><Intervention><Intestinal><Intestines><Intravenous><Investigation><Investigators><Ivacaftor><Kinetics><Link><Mammalian Cell><Measurement><Measures><Mediating><Medical><Messenger RNA><Mice><Mice Mammals><Modeling><Modern Man><Molecular Chaperones><Molecular Genetics><Molecular Interaction><Mucoviscidosis><Murine><Mus><Mutation><N-terminal><NH2-terminal><NIH><National Institutes of Health><Non-sense Mediated Decay><Nonsense-Mediated Decay><Organoids><Origin of Life><Other Genetics><Outcome><Pancreas><Pancreatic><Pathway interactions><Patients><Peptide Synthesis><Peptidyl Transferases><Peptidyl Translocases><Peptidyltransferase><Peripheral><Persons><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Phenotype><Phenylalanine><Physiology><Plasma Membrane><Predisposition><Protein Conformation><Protein Inhibition><Proteins><Quality Control><RNA Seq><RNA sequencing><RNA, ribosomal, 25S><RNAseq><Refractory><Regulator Genes><Reporting><Repression><Research><Research Personnel><Researchers><Respiratory Epithelium><Ribo-seq><Ribosomal Proteins><Ribosomes><Safety><Severities><Short interfering RNA><Site><Small Interfering RNA><Stop Codon><Structure of respiratory epithelium><Susceptibility><Termination Codon><Terminator Codon><Testing><Thyroid><Thyroid Gland><Thyroid Head and Neck><Time><Tissues><Transcript><Transcriptional Regulatory Elements><Translation Initiation><Translation Stop Signal><Translations><Transpeptidases><United States National Institutes of Health><Universities><VX-770><Variant><Variation><Work><Yeasts><airway epithelium><antibiotic G 418><antisense oligo><autosome><base><bases><bioelectric><bioelectricity><biosynthesis><bowel><bronchial epithelium><cellular targeting><clinical intervention><clinical therapy><computer biology><cystic fibrosis airway epithelia><cystic fibrosis mouse><cystic fibrosis mouse model><cystic fibrosis transmembrane regulator><disease phenotype><genetic condition><genetic disorder><genetic trans acting element><genome mutation><genome scale><genome-wide><genomewide><guanosinetriphosphatase><heterozygosity><human disease><ileum><improved><in vivo><inhibit protein><inhibit proteins><knock-down><knockdown><mRNA><mRNA Expression><mRNA Stability><mRNA Surveillance><multidisciplinary><mutant><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathway><pharmaceutical><phenomics><plasmalemma><polypeptide><premature><prematurity><protein expression><protein inhibitions><protein structure><protein structures><proteins structure><regulatory gene><respiratory tract epithelium><ribosome footprint profiling><ribosome profiling><siRNA><synergism><therapeutic target><trafficking><trans acting element><transcriptome sequencing><transcriptomic sequencing><translation><translation factor><translational impact><trial regimen><trial treatment><ΔF508>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Brennan H. Baker

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$244,123
FY 2026

Project Title

Mechanisms and Modifiers of Prenatal Acetaminophen Exposure and Child Neurodevelopment

Grant Number:

1K99MH138623-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Acetaminophen, which is found in more than 600 prescription and non-prescription medications for mild to moderate pain and fever reduction, is not restricted to pharmacies and is sold over-the-counter in many countries, including the United States. In most populations worldwide, over...

Research Terms

<0-11 years old><AD/HD><ADHD><APAP><Accounting><Acetamidophenol><Acetaminophen><Acetominophen><Adolescent Psychiatry><Affect><Alleles><Allelomorphs><American><Animal Experimental Use><Animal Experimentation><Animal Research><Animals><Asian group><Asian individual><Asian people><Asian population><Asians><Attention deficit hyperactivity disorder><Award><Biological><Biological Markers><Blood><Blood - brain barrier anatomy><Blood Reticuloendothelial System><Blood-Brain Barrier><Brain><Brain Nervous System><Causality><Cells Placenta-Tissue><Child><Child Health><Child Psychiatry><Child Psychology><Child Youth><Children (0-21)><Clinic><Clinical Trials><Counseling><Country><Data><Development><Disease><Disorder><Doctor of Philosophy><Drugs><Encephalon><Environment><Epidemiologic Research><Epidemiologic analysis><Epidemiology><Etiology><European><Exposure to><Fellowship><Fetus><Fever><Food and Drug Administration><Future><Gene set enrichment analysis><Gene variant><Genes><Genetic><Genetic Risk><Genome><Genomics><Genotype><Gestation><Goals><Harm Minimization><Harm Reduction><Hemato-Encephalic Barrier><Hepatotoxic effect><Hepatotoxicity><Heritability><Heterogeneity><Hydroxyacetanilide><Individual><Intervention><Knowledge><Lead><Learning><Link><Literature><Liver Toxicity><Measurement><Measures><Mediating><Medical Care Costs><Medication><Medicine><Mental health promotion><Mentors><Metabolic><Methods><Modeling><Molecular><Multiomic Data><Neural Development><Neurodevelopmental Disorder><Neurological Development Disorder><Neuropsychologies><Neuropsychology><Normal Placentoma><Outcome><Outcome Study><Oxidation-Reduction><Pain><Painful><Paracetamol><Pathology><Pathway interactions><Pb element><Pediatric Psychology><Pediatrics><Ph.D.><PhD><Pharmaceutical Preparations><Pharmaceutics><Pharmacies><Pharmacogenetics><Pharmacogenomics><Pharmacy (field)><Pharmacy facility><Phase><Placenta><Placenta Embryonic Tissue><Placentome><Population><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Pregnancy><Pregnant Women><Prevalence><Prevention><Preventive><Process><Prospective Studies><Psychiatrist><Psychiatry><Psychopathology><Pyrexia><QOL><Quality of life><Recommendation><Redox><Regression Analyses><Regression Analysis><Regression Diagnostics><Reporting><Research><Research Associate><Risk><Safety><Schools><Series><Site><Statistical Regression><Subgroup><Substance abuse problem><Techniques><Testing><Therapeutic><Toxic effect><Toxic effect on liver cells><Toxicities><Training><USFDA><United States><United States Food and Drug Administration><Variant><Variation><Work><abnormal psychology><abuse of substances><allelic variant><animal experimentations><associate faculty><associate professor><bio-markers><biologic><biologic marker><biomarker><bloodbrain barrier><career><causation><child developmental psychology><cohort><data integration><decreased income><develop therapy><developmental><disease causation><drug/agent><epidemiologic><epidemiologic evaluation><epidemiologic investigation><epidemiological><expectant mother><expectant women><expecting mother><expecting women><experience><exposed in utero><febrile><febris><fetal><fetal blood><fetal exposure><genetic variant><genome scale><genome-wide><genomewide><genomic variant><heavy metal Pb><heavy metal lead><hepatic toxicity><hepatoxicity><in utero exposure><income loss><individuals who are pregnant><insight><intervention development><intra-uterine environmental exposure><intrauterine environmental exposure><investigate epidemiology><kids><lost earning><lost income><lost wage><medical costs><medical expenses><meeting><meetings><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><mid-career faculty><midcareer faculty><minimal risk><molecular biomarker><molecular marker><multidisciplinary><multiomics><multiple omic data><multiple omics><neurobehavioral disorder><neurodevelopment><neurodevelopmental disease><neuron toxicity><neuronal toxicity><neuropsychiatric><neuropsychiatry><neuropsychologic><neurotoxic><neurotoxicity><non targeted analysis><nontargeted approach><nontargeted method><nontargeted technique><oxidation reduction reaction><panomics><pathway><people who are pregnant><pharmaceutic><post-doc><post-doctoral><post-doctoral trainee><precision medicine><precision-based medicine><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal><prenatal exposure><prenatally exposed><prevent><preventing><prospective research study><prospective survey><public health priorities><reduced income><research associates><skill acquisition><skill development><skills><statistics><study epidemiology><substance abuse><suicide rate><survey epidemiology><therapy development><those who are pregnant><tool><training opportunity><transcriptomics><treatment development><unborn><untargeted analysis><untargeted analytical approach><untargeted analytical method><untargeted analytical technique><untargeted approach><untargeted investigations><untargeted method><untargeted strategy><untargeted technique><women who are pregnant><youngster>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jacqueline Elizabeth Paniccia

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$210,168
FY 2026

Project Title

Dissecting Glutamatergic Pathway-Specific Ensembles Guiding Motivated Behavior

Grant Number:

1K99DA065878-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Opioid use disorder (OUD) is a devastating public health crisis, characterized by a lack of inhibitory control over drug seeking. Opioid use causes persistent adaptations in the excitatory circuitry governing motivated behavior, enabling drug-paired cues to trigger seeking d...

Research Terms

<2-photon><Ammon Horn><Appetite><Behavior><Behavioral><Calcium><Cell Body><Cells><Cessation of life><Communication><Computer Analysis><Computer Models><Computerized Models><Connector Neuron><Cornu Ammonis><Corpus Striatum><Corpus striatum structure><Coupling><Cues><Data><Data Analyses><Data Analysis><Data Set><Death><Desire for food><Development><Diacetylmorphine><Diamorphine><Disinhibition><Dopamine Receptor><Drug Exposure><Drugs><Electrophysiology><Electrophysiology (science)><Elements><Exposure to><Extinction><Future><Genetic><Glutamates><Goals><Grant><Head><Heroin><Hippocampus><Holography><Image><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Investigation><Investigators><L-Glutamate><Laboratories><Learning><Light><Mediating><Medication><Mice><Mice Mammals><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Nucleus Accumbens><Opiate Receptors><Opiates><Opioid><Opioid Receptor><Opsin><Outcome><Parvalbumins><Pathway interactions><Pattern><Pharmaceutical Preparations><Photoradiation><Predisposition><Public Health><Relapse><Research><Research Personnel><Researchers><Rewards><Rod-Opsin><Saccharose><Self Administered><Self Administration><Slice><Stimulus><Striate Body><Striatum><Sucrose><Susceptibility><Synapses><Synaptic><System><Testing><Thalamic structure><Thalamus><Training><Visualization><behavioral disinhibition><calcium indicator><career><cell type><computational analyses><computational analysis><computational modeling><computational models><computer analyses><computer based models><computerized modeling><data interpretation><developmental><drug/agent><electrophysiological><experience><experiment><experimental research><experimental study><experiments><functional adaptation><glutamatergic><heroin intake><heroin use><hippocampal><imaging><in vivo><inhibitory neuron><insight><motivated behavior><neural adaptation><neuroadaptation><neuronal><opiate consumption><opiate drug use><opiate intake><opiate use><opiate use disorder><opioid consumption><opioid drug use><opioid intake><opioid use><opioid use disorder><optogenetics><patch clamp><pathway><prevent relapse><programs><relapse prevention><response><spatial and temporal><spatial temporal><spatiotemporal><striatal><synapse><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><thalamic><treatment strategy><two-photon>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Veronika Kondev

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$181,092
FY 2026

Project Title

Dopamine receptor type 2 (D2)-expressing cells in the ventral hippocampus controlrelapse behavior

Grant Number:

1K99DA065809-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Substance use disorders (SUDs) have surged in prevalence, with cocaine-related overdose deaths disproportionately affecting marginalized populations. Dysfunctional dopamine (DA) signaling has been tied to SUD, with extensive research into DA signaling within mesocorticolimbic circuits specifically f...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Ammon Horn><Animal Behavior><Behavior><Behavioral><Bioinformatics><Biological Function><Biological Markers><Biological Process><Brain><Brain Nervous System><CB1><CB1 Receptor><CB1R><CB2><CB2 Receptor><CB2R><CNR1 gene><CNR2><CNR2 gene><CRISPR><CRISPR/Cas system><Calcium><Cannabinoid Receptor CB1><Cannabinoid Receptor CB2><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Characteristics><Clustered Regularly Interspaced Short Palindromic Repeats><Cocaine><Cocaine use disorder><Consumption><Cornu Ammonis><Corpus Striatum><Corpus striatum structure><Cue-induced relapse><Cues><Data><Dopamine><Dopamine Receptor><Down-Regulation><Drug Combinations><Drug Modulation><Drug Therapy><Drugs><ECB signaling><Electrophysiology><Electrophysiology (science)><Encephalon><Endocannabinoids><Endogenous Cannabinoids><Exhibits><Extinction><FDA approved><Future><Genes><Genetic><Glutamates><Goals><Hippocampus><Hydroxytyramine><Image><Impairment><Individual><Intake><Intermediary Metabolism><Intervention><Intracellular Communication and Signaling><Intravenous><L-Glutamate><Laboratories><Life><Link><Machine Learning><Mediating><Medication><Metabolic Processes><Metabolism><Molecular><Motivation><Nerve Cells><Nerve Unit><Network Analysis><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Outcome><Pathway Analysis><Pathway interactions><Pattern><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Photons><Play><Population><Population Heterogeneity><Predisposition><Prevalence><Protocol><Protocols documentation><Psychological reinforcement><Public Health><Pyramidal neuron><RNA Seq><RNA sequencing><RNAseq><Regulation><Reinforcement><Relapse><Research><Role><Self Administered><Self Administration><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Sorting><Stimulus><Striate Body><Striatum><Substance Use Disorder><Supporting Cell><Susceptibility><Synapses><Synaptic><Synaptic plasticity><Testing><Therapeutic><Training><Treatment outcome><United States><Validation><Viral><abused drug><abused drugs><addiction><addiction liability><addiction potential><addictive disorder><adulthood><behavior phenotype><behavioral phenotyping><bio-markers><biologic marker><biological signal transduction><biomarker><cannabinoid receptor 1><cannabinoid receptor 2><cannabinoid receptor type 1><cannabinoid receptor type 2><cannabinoid type 1><cell type><cocaine relapse><cocaine seeking><conditioned place preference><differential expression><differentially expressed><diverse populations><drug abused><drug intervention><drug of abuse><drug seeking behavior><drug treatment><drug/agent><drugs abused><drugs of abuse><electrophysiological><endocannabinoid signaling><endophenotype><gene interaction><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><global gene expression><global transcription profile><glutamatergic><heterogeneous population><hippocampal><hippocampal pyramidal neuron><imaging><improved><indexing><insight><knock-down><knockdown><machine based learning><marginalized group><marginalized individual><marginalized people><marginalized population><neural><neural mechanism><neuromechanism><neuronal><novel><overdose death><overdose fatalities><pathway><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><place conditioning><population diversity><potential biological marker><potential biomarker><presynaptic><prevent relapse><programs><relapse against cocaine><relapse prevention><reward circuitry><reward processing><sNuc-Seq><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><striatal><substance use and disorder><synapse><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><trait><transcriptional differences><transcriptome><transcriptome sequencing><transcriptomic sequencing><transcriptomics><validations>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Lingyu Xu

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$169,020
FY 2026

Project Title

Genomic and Clinical Mechanisms and Prognostic Implications of Myocardial Lipomatous Metaplasia

Grant Number:

1K99HL183672-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/10/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Myocardial fibrosis (MF) has been traditionally considered the critical anatomic substrate for cardiac dysfunction, remodeling, and malignant arrhythmia. During my postdoctoral training, supervised by Dr. Saman Nazarian, I adopted a multimodal strategy to characterize myocardial lipomatous metaplasi...

Research Terms

<Adipocytes><Adipose Cell><Adipose tissue><Adopted><Anatomic Sites><Anatomic structures><Anatomy><Apoplexy><Architecture><Arrhythmia><Biological><Bleeding><Body Tissues><Brain Vascular Accident><CAT scan><CT X Ray><CT Xray><CT imaging><CT scan><Cardiac><Cardiac Arrhythmia><Cardiac Diseases><Cardiac Disorders><Cardiomyopathies><Causality><Cell Communication and Signaling><Cell Signaling><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Chest><Chronic><Cicatrix><Clinical><Computed Tomography><Data><Disease><Disorder><Dysfunction><Electrophysiology><Electrophysiology (science)><Engineering / Architecture><Etiology><Event><Exhibits><Fat Cells><Fats><Fatty Tissue><Fatty acid glycerol esters><Fe element><Fe overload><Fibroblasts><Fibrosis in the heart><Fibrosis in the myocardium><Fibrosis within the heart><Fibrosis within the myocardium><Fibrotic myocardium><Foundations><Functional disorder><GWA study><GWAS><Gadolinium><Gd element><Gene variant><Genetic><Genomics><Genotype><Goals><Heart><Heart Arrhythmias><Heart Diseases><Heart failure><Hemorrhage><Hemostasis><Hemostatic function><Heritability><Image><Infarction><Infiltration><Inflammation><Intervention><Intracellular Communication and Signaling><Iron><Iron Overload><Ischemia><Link><Linkage Disequilibrium><Lipocytes><Magnetic Resonance><Malignant><Malignant - descriptor><Mature Lipocyte><Mature fat cell><Medicine><Mendelian randomization><Metaplasia><Metaplastic Change><Modeling><Multipotent Stem Cells><Myocardial><Myocardial Diseases><Myocardial Disorder><Myocardial depression><Myocardial dysfunction><Myocardiopathies><Myocardium><Neurophysiology / Electrophysiology><Obesity><Outcome><Participant><Pathologic><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pattern><Pericardial><Pericardial body location><Phenotype><Physiopathology><Play><Population><Population Heterogeneity><Postdoc><Postdoctoral Fellow><Prevalence><Pump><Recurrence><Recurrent><Reporting><Research><Research Associate><Role><Sample Size><Sampling><Scars><Signal Transduction><Signal Transduction Systems><Signaling><Stroke><Surrogate Markers><Survival Analyses><Survival Analysis><Testing><Therapeutic><Thorace><Thoracic><Thorax><Tissues><Tomodensitometry><Training><Validation><Variant><Variation><Ventricular Tachycardia><Work><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><adipose><adiposity><adverse consequence><adverse outcome><allelic variant><biobank><biologic><biological signal transduction><biorepository><blood loss><brain attack><candidate identification><cardiac MRI><cardiac dysfunction><cardiac failure><cardiac fibrosis><cardiac magnetic resonance imaging><cardiac muscle><cardiometabolic><cardiometabolism><catscan><causation><cerebral vascular accident><cerebrovascular accident><clinical phenotype><computed axial tomography><computer tomography><computerized axial tomography><computerized tomography><coronary fibrosis><corpulence><deep learning based model><deep learning model><disease causation><diverse populations><electrophysiological><fibrotic heart><genetic analysis><genetic architecture><genetic variant><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic data><genomic dataset><genomic variant><heart disorder><heart dysfunction><heart fibrosis><heart muscle><heterogeneous population><imaging><improved><infarct><ischemic cardiomyopathy><mortality><multi-modality><multimodality><multipotent progenitor><multipotent progenitor cell><myocardial fibrosis><myocardium disease><myocardium disorder><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><non-contrast CT><noncontrast CT><noncontrast computed tomography><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathophysiology><patient oriented outcomes><population diversity><post-doc><post-doctoral><post-doctoral trainee><post-doctoral training><precision medicine><precision-based medicine><prevent><preventing><prognostic><prophylactic><research associates><risk stratification><social role><statistics><stratify risk><stroked><strokes><surrogate bio-markers><surrogate biomarkers><therapeutic target><trait><translational study><validations><white adipose tissue><whole genome association analysis><whole genome association study><yellow adipose tissue>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Denis James Wakeham

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$143,461
FY 2026

Project Title

High-resolution phenotyping of the hemodynamic consequences of thoracic aortic aneurysm repair

Grant Number:

1K99HL179245-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY In adults with descending thoracic aortic aneurysm (TAA), vascular repair (grafting) reduces the ~20% yearly rate of rupture and/or mortality but is associated with negative perioperative consequences. Currently, thoracic endovascular aortic repair (TEVAR) has become the standard tre...

Research Terms

<21+ years old><Acute><Adult><Adult Human><Age><Aneurysm><Aorta><Aortic Diseases><Aortic Rupture><Aortic Segment><Area><Arteries><Attenuated><Blood Pressure><Blood Vessels><Blood flow><Brain><Brain Nervous System><Cardiac><Carotid Arteries><Catheters><Central Artery><Cerebrovascular Circulation><Cerebrum><Chest><Clinical Management><Community Medicine><Consensus><Data><Descending aorta><Development><Disease><Disease Management><Disorder><Disorder Management><Dissection><EFRAC><Echography><Echotomography><Ejection Fraction><Encephalon><Ensure><Exercise><Foundations><Funding><Future><Geometry><Glomerular Filtration Rate><Health><Heart><Hospitals><Hypertension><Iohexol><Iohexol 350><Kidney><Kidney Urinary System><LV Mass><Left Ventricular Mass><Letters><Light Reflection Rheography><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Mechanics><Medical Device><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medical Ultrasound><Mentors><Morbidity><Morbidity - disease rate><NIH><NMR Imaging><NMR Tomography><National Institutes of Health><Nuclear Magnetic Resonance Imaging><Operative Procedures><Operative Surgical Procedures><Organ><Outcome Assessment><Pathologic><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Perfusion><Perioperative><Phase><Phenotype><Photoplethysmography><Photoreflexometries><Photoreflexometry><Physiology><Postoperative Complications><Property><Recommendation><Renal function><Reporting><Research><Resolution><Rest><Risk><Rupture><Structure><Surgical><Surgical Interventions><Surgical Procedure><Technology><Testing><Thorace><Thoracic><Thoracic Aortic Aneurysm><Thoracic aorta><Thorax><Transmission><Ultrasonic Imaging><Ultrasonogram><Ultrasonography><Ultrasound Diagnosis><Ultrasound Medical Imaging><Ultrasound Test><United States National Institutes of Health><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Zeugmatography><adulthood><adverse consequence><adverse outcome><age associated><age correlated><age dependent><age linked><age related><age specific><ages><aortic disorder><arterial tonometry><ascending aorta><attenuate><attenuates><blood flow in brain><blood pressure elevation><brain blood circulation><brain blood flow><cardiac function><career development><cerebral><cerebral blood flow><cerebral circulation><cerebrocirculation><cerebrovascular blood flow><compare to control><comparison control><design><designing><developmental><diagnostic ultrasound><elevated blood pressure><function of the heart><heart function><hemodynamics><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><increase in blood pressure><increased blood pressure><kidney function><mechanic><mechanical><morbidity rate><mortality><natural aging><non-compliance><non-compliant><noncompliance><noncompliant><normal aging><normative aging><patient oriented outcomes><post-operative complications><pressure><renal><renal artery><repair><repaired><resolutions><response><sex><shear stress><skills><sonogram><sonography><sound measurement><standard care><standard treatment><surgery><transmission process><ultrasound><ultrasound imaging><ultrasound scanning><vascular>
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Fatema Bhinderwala

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$141,566
FY 2026

Project Title

From Atoms to Organoids: Understanding the Conformational Landscape and Regulation of Small GTPases

Grant Number:

1K99CA300901-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/24/2026

End Date:

2/28/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract In the United States alone, over 250,000 people suffer from Small GTPase (smG) dysfunction linked to cancer, and this number scales to 3.4 million people worldwide. The smG proteins interconvert between the GDP-bound inactive form and the GTP-bound active form, where the act...

Research Terms

<Address><Affect><Affinity><Amino Acids><Assay><Attention><Automobile Driving><Binding><Binding Proteins><Bioassay><Biochemical><Biological><Biological Assay><Cancers><Cell Body><Cell Communication and Signaling><Cell Locomotion><Cell Migration><Cell Movement><Cell Nucleus><Cell Signaling><Cells><Cellular Migration><Cellular Motility><Characteristics><Communities><Complex><Coupled><Crystallographies><Crystallography><Cytosol><DNA mutation><Data><Detection><Development><Disease><Disorder><Dissociation><Drug Design><Drug Interactions><Drug Targeting><Dysfunction><Environment><Family><Functional disorder><Future><GAP Proteins><GDI Proteins><GDIs><GDP Dissociation Factor><GDP Dissociation Inhibitors><GDP Dissociation Stimulators><GDP Exchange Factors><GDP-GTP Exchange Protein><GDP-GTP Reversing Factors><GTP><GTP Binding><GTP GDP exchange factor><GTP Phosphohydrolases><GTP bound><GTPase-Activating Proteins><GTPases><Gastric Body Cancer><Gastric Cancer><Gastric Cardia Cancer><Gastric Fundus Cancer><Gastric Neoplasms><Gastric Pylorus Cancer><Gastric Tumor><Gene Expression><Generalized Growth><Genetic Change><Genetic defect><Genetic mutation><Germinoblastic Sarcoma><Germinoblastoma><Glues><Goals><Growth><Guanine><Guanine Nucleotide Dissociation Inhibitors><Guanine Nucleotide Exchange Factors><Guanine Nucleotide Exchange Protein><Guanine Nucleotide Releasing Factors><Guanosine Triphosphate><Guanosine Triphosphate Phosphohydrolases><Guanosinetriphosphatases><Guanyl-Nucleotide Exchange Factor><Guanyl-Nucleotide Releasing Factor><Hydrolysis><In Vitro><Intracellular Communication and Signaling><Knowledge><Label><Ligand Binding><Ligand Binding Protein><Ligand Binding Protein Gene><Ligands><Link><Lymphoma><Malignant Cell><Malignant Gastric Neoplasm><Malignant Gastric Tumor><Malignant Lymphoma><Malignant Neoplasms><Malignant Tumor><Measurement><Measures><Mediating><Methodology><Methods><Mission><Modeling><Molecular><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Monomeric G-Proteins><Monomeric GTP-Binding Proteins><Motion><Mutation><Nature><Nuclear Magnetic Resonance><Nucleotides><Nucleus><Oncogenic><Optics><Organoids><Pancreas Neoplasms><Pancreas Tumor><Pancreatic Tumor><Pathologic><Patients><Persons><Phase><Phenotype><Physiologic><Physiological><Physiopathology><Position><Positioning Attribute><Process><Proliferating><Property><Protein Binding><Protein Dynamics><Proteins><Regulation><Regulatory Protein><Research><Resolution><Reticulolymphosarcoma><RhoGDI><Role><Shapes><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Single Crystal Diffraction><Small G-Proteins><Small GTPases><Stomach Cancer><Stomach Neoplasms><Stomach Tumor><Structure><Structure-Activity Relationship><Techniques><Time><Tissue Growth><Tumor Cell><United States><Variant><Variation><Work><X Ray Crystallographies><X-Ray Crystallography><X-Ray Diffraction Crystallography><X-Ray/Neutron Crystallography><Xray Crystallography><aminoacid><analog><biologic><biological signal transduction><biophysical approaches><biophysical methodology><biophysical methods><biophysical techniques><bound protein><cancer cell><cancer cell metabolism><cancer metabolism><cell motility><cell type><chemical structure function><conformation><conformational><conformational state><conformationally><conformations><design><designing><developmental><driving><drug development><entire genome><exchange factor><experiment><experimental research><experimental study><experiments><full genome><gain of function><gain of function mutation><gastric malignancy><genetic regulatory protein><genome mutation><genome sequencing><guanosinetriphosphatase><guanosinetriphosphatase activating protein><improved><inhibitor><insight><leukemia><malignancy><malignant stomach neoplasm><malignant stomach tumor><member><mutant><neoplasm/cancer><neoplastic cell><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><ontogeny><optical><pancreatic cancer cells><pancreatic neoplasia><pancreatic neoplasm><pancreatic tumor cells><pathophysiology><prevent><preventing><programs><protein protein interaction><regulatory gene product><resolutions><rho><rho G-Proteins><rho GDI><rho GTP-Binding Proteins><rho GTPases><rho Protein P21><rho Small GTP-Binding Proteins><rhoB p20 GDI><screening><screenings><social role><stomach fundus cancer><stomach pylorus cancer><structural biology><structure function relationship><success><time use><tool><tumor><tumor cell metabolism><tumor metabolism><whole genome>
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Jonathan Vernon Gill

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$139,617
FY 2026

Project Title

Neural circuits supporting olfactory computation and perception

Grant Number:

1K99DC023640-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY This project aims to uncover the circuit and computational mechanisms that support olfactory perception. Odors evoke spatially distributed patterns of activity across olfactory bulb (OB) glomeruli, which in turn drive temporally structured responses in mitral and tufted cells (MTCs)...

Research Terms

<2-photon><Area><Behavior><Brain><Brain Nervous System><Business-Friendly Atmosphere><Calcium><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Signaling><Cell-to-Cell Interaction><Cells><Code><Coding System><Complex><Connectionist Models><Connector Neuron><Data><Degenerative Neurologic Disorders><Diagnosis><Electrophysiology><Electrophysiology (science)><Encephalon><Exhibits><Exposure to><Foundations><Goals><Image><In vivo analysis><Individual><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intracellular Communication and Signaling><Laboratories><Lateral><Learning><Logic><Maps><Measures><Mentors><Mice><Mice Mammals><Modification><Monitor><Murine><Mus><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural Network Models><Neural Network Simulation><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic><Neurologic Degenerative Conditions><Neurological><Neurons><Neurophysiology / Electrophysiology><Odors><Olfaction><Olfactory Pathways><Olfactory system><Optical Methods><Output><Pattern><Perception><Perceptrons><Phase><Play><Population><Postdoc><Postdoctoral Fellow><Probability><Property><Reaction Time><Receptor Protein><Recurrence><Recurrent><Research><Research Associate><Respiration><Response RT><Response Time><Role><Sensory><Shapes><Si element><Signal Transduction><Signal Transduction Systems><Signaling><Silicon><Smell><Smell Perception><Stimulus><Structure><Survey Instrument><Surveys><Synapses><Synaptic><Techniques><Technology><Testing><Training><Transmission><Work><awake><biological signal transduction><business-friendly environment><cell cortex><collaborative atmosphere><collaborative environment><contrast enhanced><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><electrophysiological><experience><experiment><experimental research><experimental study><experiments><holographic stimulation><imaging><in silico><in vivo evaluation><in vivo testing><insight><interactive atmosphere><interactive environment><interdisciplinary atmosphere><interdisciplinary environment><neural><neural circuit><neural circuitry><neurocircuitry><neurodegenerative illness><neuronal><novel><odor perception><olfactory bulb><olfactory bulb glomeruli><olfactory bulb glomerulus><olfactory circuitry><olfactory circuits><olfactory glomeruli><olfactory glomerulus><olfactory perception><optic imaging><optical imaging><optogenetics><peer-group atmosphere><peer-group environment><piriform cortex><post-doc><post-doctoral><post-doctoral trainee><psychomotor reaction time><receptor><research associates><respiratory mechanism><response><sensory mechanism><sensory neuroscience><sensory system><skills><social role><spatial and temporal><spatial temporal><spatiotemporal><synapse><synaptic circuit><synaptic circuitry><temporal measurement><temporal resolution><time measurement><transmission process><two-photon>
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Moriah Paige Bellissimo

VIRGINIA COMMONWEALTH UNIVERSITY, RICHMOND, VA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$133,458
FY 2026

Project Title

Mechanisms and Efficacy of Physical Activity to Reduce Cardiovascular Morbidity in Women with Breast Cancer

Grant Number:

5K99HL173554-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/10/2025

End Date:

12/31/2026

Why this may be worth a closer look

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  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Reduced exercise capacity is the hallmark symptom of heart failure (HF) and the primary morbidity experienced by women treated for breast cancer (BC). No established therapies exist to mitigate treatment-related declines in exercise capacity and lower HF risk in BC survivors. We foun...

Research Terms

<Active Follow-up><Activities of Daily Living><Activities of everyday life><Address><Adherence><Aerobic><Aerobic Activity><Aerobic Exercise><Aerobic Training><Aerobic fitness><Award><Behavior><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Model><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Beta Proprotein Interleukin 1><Biological Function><Biological Process><Blood Serum><Breast Cancer><Breast Cancer Patient><Breast Cancer Treatment><Breast Cancer survivor><Breast Cancer therapy><Breast Tumor Patient><Cancer Patient><Cancer Survivor><Cancer Treatment><Cancers><Cardiac Toxicity><Cardiotoxic><Cardiotoxicity><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular Physiology><Cardiovascular system><Cell Communication and Signaling><Cell Signaling><Clinical Trials><Conditioning Therapy><Data><ELISA><Enrollment><Enzyme-Linked Immunosorbent Assay><Exercise><Fatigue><Fats><Fatty acid glycerol esters><Funding><Future><Gene Transcription><Genetic Transcription><Goals><Heart Injuries><Heart Vascular><Heart failure><IFN-Gamma-Inducing Factor Gene><IFN-gamma-Inducing Factor><IGIF><IGIF Gene><IL-1 Gamma><IL-1 Gamma Gene><IL-1 beta><IL-1 β><IL-1-b><IL-18><IL-18 Gene><IL-1g><IL-1g Gene><IL-1β><IL1-Beta><IL1-β><IL18><IL18 Protein><IL18 gene><IL1B Protein><IL1F2><IL1F4><IL1F4 Gene><IL1β><Iatrogenic Cancer><Immunity><Improve Access><Individual><Infiltration><Inflammasome><Inflammation><Interferon-Gamma-Inducing Factor Gene><Interferon-gamma-Inducing Factor><Interleukin 18 (Interferon-Gamma-Inducing Factor)><Interleukin 18 (Interferon-Gamma-Inducing Factor) Gene><Interleukin 18 Proprotein><Interleukin 18 Proprotein Gene><Interleukin 1beta><Interleukin-1 Gamma><Interleukin-1 Gamma Gene><Interleukin-1 beta><Interleukin-18><Interleukin-18 Precursor><Interleukin-18 Precursor Gene><Interleukin-1β><Intervention><Intracellular Communication and Signaling><Investigators><Lack of Energy><Learning><Leisures><Life Style><Lifestyle><MGC12320><MGC12320 Gene><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Malignant Breast Neoplasm><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mentors><Morbidity><Muscle><Muscle Tissue><Myocardium><NHLBI><NIH><NMR Imaging><NMR Tomography><National Heart, Lung, and Blood Institute><National Institutes of Health><Nuclear Magnetic Resonance Imaging><Outcome Assessment><Participant><Patient Self-Report><Patients><Phase><Physical activity><Population><Preinterleukin 1 Beta><Preventative strategy><Prevention strategy><Preventive strategy><Primary Prevention><Production><Prospective cohort><RNA Expression><Randomization trial><Receptor Protein><Recommendation><Regimen><Reporting><Research Personnel><Researchers><Risk><Self-Report><Serum><Signal Transduction><Signal Transduction Systems><Signaling><Sterility><Strenuous Exercise><Structure><Survey Instrument><Surveys><Symptoms><Testing><Therapy Related Malignant Neoplasm><Therapy Related Malignant Tumor><Therapy-Associated Cancers><Therapy-Related Cancer><Time><Training><Training Programs><Transcription><Travel><Treatment-Associated Cancer><Treatment-Related Cancer><United States National Institutes of Health><Walking><Woman><Women's cohort><Work><Zeugmatography><active followup><anti-cancer therapy><arm><behavior intervention><behavioral clinical trial><behavioral intervention><biological signal transduction><cancer therapy><cancer type><cancer-directed therapy><cardiac failure><cardiac function><cardiac injury><cardiac muscle><cardioprotectant><cardioprotection><cardioprotective><cardiovascular disorder><cardiovascular function><career><chemotherapy><circulatory system><clinical care><clinical significance><clinically significant><cohort in women><cohort on women><daily living function><daily living functionality><design><designing><develop therapy><enroll><enzyme linked immunoassay><exercise capacity><exercise intervention><exercise intolerance><exercise program><experience><female cohort><female morbidity><female outcomes><female treatment><fitness program><follow up><follow-up><followed up><followup><function of the heart><functional ability><functional capacity><health related quality of life><heart function><heart muscle><high risk group><high risk individual><high risk people><high risk population><improved><improved outcome><individuals with breast cancer><intense exercise><intervention development><life style intervention><lifestyle intervention><malignancy><malignant breast tumor><meeting><meetings><morbidity among females><morbidity among women><morbidity in females><morbidity in women><mortality><muscle strengthening><muscular><neoplasm/cancer><novel><outcomes among females><outcomes among women><outcomes in females><outcomes in women><patients with breast cancer><person with breast cancer><physical activity intervention><preservation><prevent><preventing><programs><prospective><protective effect><randomized trial><receptor><recruit><skills><sterile><strength training><strenuous activity><strenuous physical activity><systemic inflammation><systemic inflammatory response><theories><therapy development><treat females><treat women><treatment among females><treatment among women><treatment development><treatment in females><treatment in women><vigorous exercise><vigorous physical activity><women's morbidity><women's outcomes><women's treatment>
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Anees Kazi

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$133,077
FY 2026

Project Title

Multi-Modal Biomedical Data Fusion via Artificial Intelligence (AI)

Grant Number:

1K99EB037082-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY AND ABSTRACT Existing AI struggles to combine multiple data types for disease prediction. This project proposes a novel deep learning method that tackles this by fusing three data sources (clinical notes, lab results, images) compared to current two-source methods. The model will lea...

Research Terms

<AI Augmented><AI assisted><AI driven><AI enhanced><AI integrated><AI powered><AI system><Accuracy of Diagnosis><Address><Age><Architecture><Artificial Intelligence><Artificial Intelligence enhanced><Attention><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Award><Behavioral><Biological Markers><Biomedical Research><Characteristics><Clinical><Communities><Complex><Computational toolkit><Computer Models><Computer Reasoning><Computer aided diagnosis><Computer-Assisted Diagnosis><Computerized Models><Cross Sectional Analysis><Data><Data Analyses><Data Analysis><Data Set><Data Sources><Dedications><Detection><Development><Diagnosis><Disease><Disease Progression><Disorder><EEG><Electroencephalogram><Electroencephalography><Engineering / Architecture><Future><Goals><Graph><Heterogeneity><Image><Individual><Intervention><Investigators><Learning><MR Imaging><MR Tomography><MRI><MRIs><Machine Intelligence><Machine Learning><Magnetic Resonance Imaging><Math><Mathematics><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methods><Mission><Modality><Modeling><Monitor><NIBIB><NMR Imaging><NMR Tomography><National Institute of Biomedical Imaging and Bioengineering><Network Analysis><Network-based><Nuclear Magnetic Resonance Imaging><Outcome><Pathway Analysis><Patients><Pattern><Phase><Physics><Population><Process><Psychoses><Research><Research Personnel><Researchers><Rest><Source><Specificity><Subgroup><System><Techniques><Testing><Text><Time><Training><Training Programs><Update><Variant><Variation><Work><Zeugmatography><accurate diagnosis><ages><analyzing longitudinal><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><bio-markers><biologic marker><biomarker><biomedical imaging><computational modeling><computational models><computational toolbox><computational tools><computational toolset><computer based models><computerized modeling><computerized tools><data diversity><data fusion><data interpretation><deep learning><deep learning based model><deep learning based neural network><deep learning method><deep learning model><deep learning neural network><deep learning strategy><deep neural net><deep neural network><design><designing><developmental><diagnostic accuracy><disease classification><disease subgroups><disease subtype><disorder classification><disorder subtype><diverse data><enhanced with AI><enhanced with Artificial Intelligence><genetic information><graph attention network><graph convolutional network><graph neural network><health care quality><imaging><improved><innovate><innovation><innovative><insight><longitudinal analysis><machine based learning><machine learning based model><machine learning model><multi-modal data><multi-modal datasets><multi-modality><multimodal data><multimodal data fusion><multimodal datasets><multimodal fusion><multimodality><multiple data types><neural imaging><neuro-imaging><neuroimaging><neurological imaging><nosology><novel><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><personalization of treatment><personalized diagnosis><personalized diagnostics><personalized medicine><personalized therapy><personalized treatment><precise diagnostics><precision diagnostics><recurrent neural network><sex><skills><success><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tool><treatment strategy>
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Xinxin Ge

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$130,182
FY 2026

Project Title

Identity and Function of Neurons Receiving Bottom-Up or Top-Down Inputs in the Adult and Developing V1

Grant Number:

1K99EY038331-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Our brain generates sensory perceptions by integrating externally (bottom-up) and internally (top-down) driven representations of the world. The bottom-up pathways provide information originating from the sensory periphery about the physical properties of the stimulus. The t...

Research Terms

<2-photon><21+ years old><Address><Adult><Adult Human><Afferent Neurons><Biologic Models><Biological Models><Brain><Brain Nervous System><Calcium><Categories><Classification><Development><Encephalon><Exhibits><Eye><Eyeball><Geniculate Bodies><Geniculate body structure><Goals><Image><Imaging technology><Lateral Posterior Nucleus><Lateral Posterior Thalamic Nucleus><Lateral posterior nucleus of thalamus><Location><Logic><Maps><Mental disorders><Mental health disorders><Metathalamus><Mice><Mice Mammals><Model System><Molecular><Murine><Mus><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Organism><Pathway interactions><Perception><Phase><Position><Positioning Attribute><Primary visual cortex><Property><Psychiatric Disease><Psychiatric Disorder><Research><Role><Sensory><Sensory Neurons><Stimulus><Stream><Striate Cortex><Striate area><Synapses><Synaptic><Systematics><Techniques><Testing><Thalamic structure><Thalamus><Time><Tracer><V1 neuron><Visual><Visualization><adulthood><area striata><developmental><experience><experiment><experimental research><experimental study><experiments><extrastriate area><extrastriate cortex><extrastriate visual cortex><geniculate nucleus><global gene expression><global transcription profile><imaging><in vivo two-photon imaging><insight><living system><mental illness><neuronal><novel><pathway><perceptual stimulus><physical property><physicochemical phenomena related to the senses><psychiatric illness><psychological disorder><response><sensory cortex><sensory stimulus><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><synapse><thalamic><timeline><transcriptome><transcriptomics><two-photon><visual area><visual information><visual stimulus>
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Zhuoxin Chen

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$128,191
FY 2026

Project Title

Identifying non-coding sources of mammalian craniofacial variation

Grant Number:

1K99DE034828-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Facial variations play a crucial role in human identity and social interactions, with craniofacial malformations being among the most prevalent congenital disorders. However, our understanding of the genetic factors governing mammalian craniofacial morphogenesis is still limited. The...

Research Terms

<3-D><3-Dimensional><3D><Advisory Committees><Affect><Affinity><Assay><Automobile Driving><Basal Transcription Factor><Basal transcription factor genes><Base Pairing><Binding><Bioassay><Biologic Models><Biological Assay><Biological Models><Biology><Birth Defects><Body Tissues><Breeding><Bypass><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Canine Species><Canis familiaris><Career Counseling><Career Guidance><Cas nuclease technology><Chromatin><Chromosome Mapping><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Disorders><Congenital Malformation><Craniofacial Abnormalities><DNA Alteration><DNA Sequence Alteration><Data><Development><Development Plans><Disease><Disorder><Distal><Distant><Dogs><Dogs Mammals><Educational workshop><Elements><Embryo><Embryonic><Enhancer Elements><Enhancers><Ensure><Face><Faculty><Foundations><Functional RNA><Future><GWA study><GWAS><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene Transfer Techniques><Gene variant><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Alteration><Genetic Enhancer Element><Genets><Genome><Genomics><Goals><Human><Investigation><Knowledge><Lead><Leadership><Link><Linkage Disequilibrium><Linkage Mapping><Mammalia><Mammals><Maps><Mechanics><Mentors><Mentorship><Methods><Mice><Mice Mammals><Model System><Modeling><Modern Man><Molecular Interaction><Morphogenesis><Morphology><Murine><Mus><Nature><Noncoding RNA><Nontranslated RNA><Occupational Guidance><Outcome><Pathway interactions><Pb element><Phase><Phenotype><Play><Position><Positioning Attribute><QTL><Quantitative Trait Loci><Regulation><Regulatory Element><Reporter Genes><Research><Research Proposals><Research Training><Resolution><Role><Sample Size><Secure><Sequence Alteration><Shapes><Skull><Social Interaction><Solid><Source><Specificity><Statistical Methods><Task Forces><Technology><Testing><Therapeutic Intervention><Time><Tissues><Total Human and Non-Human Gene Mapping><Training><Transcript Expression Analyses><Transcript Expression Analysis><Transcription Factor Proto-Oncogene><Transcription factor genes><Transgenesis><Transgenic Organisms><Translations><Untranslated RNA><Upstream Stimulatory Factor><Upstream Transcription Factor><Variant><Variation><Vocational Counseling><Vocational Guidance><Work><Workshop><advisory team><allelic variant><analyze gene expression><canine><career counselor><career development><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><comparative genomics><craniofacial><craniofacial anomalies><craniofacial defects><craniofacial development><craniofacial malformation><craniofacies><cranium><developmental><domestic dog><driving><enhancer sequence><entire genome><executive coaching><faces><facial><full genome><gene conservation><gene expression analysis><gene expression assay><gene interaction><genetic architecture><genetic enhancer sequence><genetic mapping><genetic variant><genome editing><genome sequencing><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic alteration><genomic editing><genomic variant><heavy metal Pb><heavy metal lead><helix-loop-helix activator USF><improved><in vivo><insight><intervention therapy><mammalian genome><mechanic><mechanical><morphogenetic process><mouse genome><noncoding><novel><pathway><promoter><promotor><resolutions><skills><social influence><social role><statistic methods><statistical learning><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tech development><technology development><three dimensional><transcription factor><transcription factor MLTF><transcription factor USF><transcriptional profiling><transgenic><translation><whole genome><whole genome association analysis><whole genome association study>
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Kate Warde

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$126,933
FY 2026

Project Title

Harnessing Androgen-Driven Immune Modulation to Enhance Immunotherapy for Endocrine Cancers

Grant Number:

1K99CA307604-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Immunotherapy has transformed cancer treatment, yet patients with endocrine tumors, including adrenal and ovarian cancers, rarely benefit due to poor immune infiltration and activation in steroid-rich environments. Androgens, traditionally viewed as cancer-promoting, may enhance anti...

Research Terms

<5 alpha-Dihydrotestosterone><5-alpha-DHT><Adrenal Cancers><Adrenal Cortex Carcinoma><Adrenal Cortical Carcinoma><Adrenal Gland Cancer><Adrenal Gland Neoplasms><Adrenal Gland Tumor><Adrenal Glands><Adrenal Tumor><Adrenals><Adrenocortical Carcinoma><Aging><Androgen Receptor><Androgenic Agents><Androgenic Compounds><Androgens><Androstanolone><Antigen Presentation><Award><Blood><Blood Reticuloendothelial System><Blood monocyte><Body Tissues><Breast><Breast Cancer><Cancer Biology><Cancer Treatment><Cancers><Castration><Cell Body><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cessation of life><Clinic><Clinical><Clinical Data><Clinical Trials><Data><Death><Development Plans><Dihydrotestosterone><Distant><Endocrine><Endocrine Cancer><Endocrine Gland Cancer><Endocrine Gland Neoplasms><Endocrine Gland Secretion><Endocrine Glands><Endocrine Organs><Endocrine System Neoplasm><Endocrine System Tumor><Endocrine Therapy><Endocrine Tumor><Environment><Exhibits><Female Reproductive Cancer><GEM model><GEMM model><Gender Bias><Genetically Engineered Mouse><Goals><Gynecologic Cancer><Gynecological Cancer><Hormonal Therapy><Hormones><Immune><Immune Cell Activation><Immune infiltrates><Immune mediated therapy><Immune response><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Tests><Immunological><Immunological Tests><Immunologically><Immunologically Directed Therapy><Immunologics><Immunomodulation><Immunotherapeutic agent><Immunotherapy><Impairment><Incidence><Inflammatory><Injections><Intracellular Communication and Signaling><Investigation><Link><Lymphoid><Lymphoid Cell><Malignant Adrenal Gland Neoplasm><Malignant Adrenal Neoplasm><Malignant Adrenal Tumor><Malignant Breast Neoplasm><Malignant Endocrine Neoplasm><Malignant Endocrine Tumor><Malignant Female Reproductive System Neoplasm><Malignant Gynecologic Neoplasm><Malignant Gynecologic Tumor><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Ovarian Neoplasm><Malignant Ovarian Tumor><Malignant Tumor><Malignant Tumor of the Adrenal Gland><Malignant Tumor of the Female Reproductive System><Malignant Tumor of the Ovary><Malignant neoplasm of ovary><Marrow monocyte><Mediating><Mentors><Mentorship><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Mice><Mice Mammals><Monitor><Murine><Mus><Myelogenous><Myeloid><Myeloid Cells><Myeloid Progenitor><Myeloid Progenitor Cells><Myeloid Stem Cells><Nature><Neoplasm Metastasis><Ovarian><Ovarian Tumor><Ovary><Ovary Cancer><Ovary Neoplasms><Ovary Tumor><PD-1 antibody><PD1 antibody><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phase><Population><Production><Prognosis><Prostate Neoplasms><Prostate Tumor><Prostatic Neoplasia><Prostatic Neoplasms><Publications><Reporting><Research><Research Resources><Resources><Role><Sampling><Scientific Publication><Secondary Neoplasm><Secondary Tumor><Sex Bias><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Site><Stanolone><Steroid Compound><Steroids><Subcellular Process><Supplementation><Surgical Castration><T cell infiltration><Testing><Testosterone><Therapeutic><Therapeutic Androgen><Therapeutic Androstanolone><Therapeutic Hormone><Therapeutic Testosterone><Time><Tissues><Training><Trans-Testosterone><Translating><Tumor Burden><Tumor Cell><Tumor Immunity><Tumor Load><Tumor-infiltrating immune cells><Validation><Work><aPD-1><aPD1><adaptive immune response><adaptive immunity><adrenal neoplasm><anti programmed cell death 1><anti-PD-1><anti-PD-1 Ab><anti-PD-1 antibodies><anti-PD-1 monoclonal antibodies><anti-PD1><anti-PD1 Ab><anti-PD1 antibodies><anti-PD1 monoclonal antibodies><anti-cancer therapy><anti-programmed cell death protein 1><anti-programmed cell death protein 1 antibodies><anti-programmed death-1 antibody><anti-tumor immunity><antiPD-1><antitumor immunity><biological signal transduction><burden of disease><burden of illness><cancer immunity><cancer immunology><cancer metastasis><cancer progression><cancer risk><cancer therapy><cancer-directed therapy><career development><check point blockade><checkpoint blockade><cytokine><deprivation><disease burden><endocrine neoplasm><genetically engineered mouse model><genetically engineered murine model><gynecologic malignancy><gynecological malignancy><hormone therapy><host response><immune activation><immune cell infiltrate><immune cell infiltration of tumors><immune cells infiltrating the tumor><immune cells that infiltrate the tumor><immune check point blockade><immune checkpoint blockade><immune drugs><immune microenvironment><immune modulation><immune regulation><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapeutics><immune-based therapies><immune-based treatments><immuno therapy><immunologic reactivity control><immunologic therapeutics><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><immunosuppressive microenvironment><immunosuppressive tumor microenvironment><immunotherapeutics><immunotherapy agent><improved><improved outcome><infiltration of tumors by immune cells><insight><intraovarian><intratumoral immune cell><intratumoral immune infiltrate><male><malignancy><malignant breast tumor><malignant endocrine gland neoplasm><malignant endocrine gland tumor><monocyte><mortality><mouse model><murine model><myeloid precursor><myeloid stem and progenitor cell><neoplasm immunology><neoplasm progression><neoplasm/cancer><neoplastic cell><neoplastic progression><novel><ovarian cancer><ovarian neoplasm><patient oriented outcomes><receptor expression><recruit><resistance to therapy><resistant to therapy><response><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><suprarenal gland><therapeutic resistance><therapy resistant><transcriptomics><translational opportunities><translational potential><treatment resistance><tumor><tumor cell metastasis><tumor immune cell><tumor immune infiltrate><tumor immune microenvironment><tumor immunology><tumor infiltration of immune cells><tumor progression><tumor-immune system interactions><ultrasound><validations><αPD-1><αPD1><♂>
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Lynn Yap

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$126,900
FY 2026

Project Title

Cellular and circuit mechanisms underlying the generation, regulation, and flexibility of value representations in mouse medial prefrontal cortex

Grant Number:

1K99MH142674-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/2/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Most sensory stimuli acquire value through learning and experience. While progress has been made in deline- ating the circuits involved in sensory value-guided behaviors, the cellular and circuit mechanisms that underlie how distinct value representations are formed during l...

Research Terms

<2-photon><3-D><3-Dimensional><3D><Adaptive Behaviors><Address><Affect><Appetite><Area><Axon><Behavior><Behavioral><Brain><Brain Nervous System><Cell Body><Cells><Complement><Complement Proteins><Coupling><Cues><Data><Data Set><Desire for food><Development Plans><Doctor of Philosophy><Electrophysiology><Electrophysiology (science)><Encephalon><Experimental Designs><Future><Generations><Genetic><Goals><Hydrogen Oxide><Image><Individual><Interneuron function><Learning><Light><Maintenance><Medial><Mental Depression><Mentors><Methods><Mice><Mice Mammals><Modeling><Molecular><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Neurosciences><Odors><Organism><Outcome><Output><PTSD><Pathway interactions><Ph.D.><PhD><Phase><Photoradiation><Population><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Postdoc><Postdoctoral Fellow><Posttraumatic Neuroses><Prefrontal Cortex><Process><Psychological reinforcement><Regulation><Reinforcement><Research><Research Associate><Reversal Learning><Rewards><Role><Sensory><Stimulus><Synapses><Synaptic><Synaptic plasticity><System><Testing><Training><Update><Water><Work><adaptation behavior><adaptive behavior><addiction><addictive disorder><behavior outcome><behavior response><behavioral extinction><behavioral outcome><behavioral response><career><career development><complementation><complex data><computational neuroscience><conditioning><density><depression><electrophysiological><executive control><executive function><experience><experiment><experimental research><experimental study><experiments><flexibility><flexible><gain of function><holographic stimulation><imaging><insight><learned behavior><learning behavior><learning extinction><living system><mouse genetics><neural><neuronal><neuropsychiatric><neuropsychiatric disease><neuropsychiatric disorder><neuropsychiatry><novel><olfactory stimulus><optic imaging><optical imaging><optogenetics><pathway><perceptual stimulus><physicochemical phenomena related to the senses><post-doc><post-doctoral><post-doctoral trainee><post-trauma stress disorder><posttrauma stress disorder><programs><research associates><response><sensory neuroscience><sensory stimulus><skills><social role><synapse><three dimensional><tool><traumatic neurosis><two-photon>
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Luke William Koblan

WHITEHEAD INSTITUTE FOR BIOMEDICAL RES, CAMBRIDGE, MA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$125,000
FY 2026

Project Title

Spatially-resolved, integrated cell state and lineage tracing to define progenitor cell dynamics in early mouse development

Grant Number:

5K99HD118574-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary: Mammalian development is a probabilistic and robust process where progenitor cells must integrate genetic, epigenetic, and environmental information to generate a complex body plan. The goal of this work is to delineate how progenitor behaviors elicit specific phenotypes in health a...

Research Terms

<3-D><3-Dimensional><3D><Adopted><Affect><Anterior><Atlases><Automobile Driving><Autoregulation><Award><Basal Transcription Factor><Basal transcription factor genes><Basic Research><Basic Science><Behavior><Benchmarking><Best Practice Analysis><Biologic Models><Biological><Biological Models><Biology><Body Tissues><Breast Cancer Model><Breast tumor model><Cancer Biology><Cardiac><Cardiac development><Cell Body><Cell Communication><Cell Function><Cell Interaction><Cell Physiology><Cell Process><Cell-to-Cell Interaction><Cells><Cellular Assay><Cellular Function><Cellular Physiology><Cellular Process><Cessation of life><Characteristics><Collaborations><Complex><DNA editor><Data><Data Analyses><Data Analysis><Data Set><Death><Development><Developmental Biology><Developmental Process><Disease><Disorder><Embryo><Embryologic Structure><Embryonic><Embryonic Structures><Engineering><Environmental Factor><Environmental Risk Factor><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Foundations><Future><GEM model><GEMM model><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genetic><Genetic Determinism><Genetic Screening><Genetically Engineered Mouse><Genomic Testing><Genomics><Goals><Growth><Health><High Throughput Assay><History><Homeostasis><Image><In Vitro><Injections><Institution><Investigators><Joints><Knock-in><Lead><Learning><Life><Lineage Tracing><Link><Logic><Maps><Mentors><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Methods><Mice><Mice Mammals><Model System><Modeling><Molecular><Monitor><Mouse ES Cell><Mouse ESC><Mouse Embryonic Progenitor><Mouse Embryonic Stem Cells><Murine><Mus><Neoplasm Metastasis><Normal Cell><Organism><Organogenesis><Outcome><Pattern><Pb element><Phase><Phenotype><Phylogeny><Physiological Homeostasis><Population Sizes><Postdoc><Postdoctoral Fellow><Primary Neoplasm><Primary Tumor><Primitive Streaks><Process><Progenitor Cells><Recording of previous events><Research><Research Associate><Research Personnel><Researchers><Resolution><Secondary Neoplasm><Secondary Tumor><Single cell seq><Structure><Subcellular Process><System><Technical Expertise><Techniques><Technology><Time><Tissue Growth><Tissues><Training><Transcription Factor Proto-Oncogene><Transcription factor genes><Translational Research><Translational Science><Trees><Work><Xenograft Model><base editing><behavior study><behavioral study><benchmark><biologic><cancer metastasis><cardiogenesis><cell assay><cell dimension><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular lineage mapping><cellular lineage tracking><data interpretation><developmental><developmental disease><developmental disorder><driving><engineered progenitor cells><engineered stem cells><environmental risk><epigenetically><experience><experiment><experimental research><experimental study><experiments><gene editor><gene function><genetic determinant><genetically engineered mouse model><genetically engineered murine model><genome based testing><genome editing><genome editor><genome testing><genomic DNA testing><genomic based testing><genomic clinical testing><genomic editing><genomic profiling testing><genomic screening test><heart development><heart formation><heavy metal Pb><heavy metal lead><high throughput screening><histories><image-based method><imaging><imaging method><imaging modality><in vitro Model><in vivo><in vivo Model><insight><knockin><living system><mESC><mammary cancer model><mammary tumor model><mouse development><mouse model><multiomics><multiple omics><murine ES cells><murine ESC><murine embryonic progenitor><murine embryonic stem cell><murine model><neuromuscular><novel><ontogeny><panomics><peer><post-doc><post-doctoral><post-doctoral trainee><prime editing><progenitor><progenitor biology><progenitor cell biology><progenitor cell division><progenitor cell expansion><progenitor cell fate specification><progenitor cell model><progenitor cell pool><progenitor cell population><progenitor cell renewal><progenitor division><progenitor expansion><progenitor fate specification><progenitor model><progenitor pool><progenitor population><progenitor renewal><progenitor specification><programs><reconstruction><research associates><resolutions><single cell next generation sequencing><single cell sequencing><skills><stem and progenitor biology><stem and progenitor cell division><stem and progenitor cell expansion><stem and progenitor cell model><stem and progenitor cell population><stem and progenitor cell renewal><stem cell based model><stem cell biology><stem cell derived model><stem cell division><stem cell expansion><stem cell fate specification><stem cell model><stem cell pool><stem cell population><stem cell renewal><stem cell specification><stem cells><technical skills><therapeutic agent development><therapeutic development><three dimensional><tool><trait><transcription factor><translation research><translational investigation><tumor cell metastasis><xenograft transplant model><xenotransplant model>
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Reika Tei

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$125,000
FY 2026

Project Title

Dissecting protein and lipid networks with membrane-centric proximity labeling

Grant Number:

1K99GM163005-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Cellular membranes serve as dynamic platforms for cell communication and signaling. On each plasma and organelle membrane, lipid–protein and protein–protein interactions are spatiotemporally organized to regulate key biological processes, such as receptor activation and oncogenic signaling. Despite ...

Research Terms

<Active Sites><Address><Ammon Horn><Antigen Binding Fragment><Antigen Targeting><Antigens><Area><Behavior><Binding><Biological Function><Biological Process><Biology><Biotin><Blood Plasma><Cell Body><Cell Communication and Signaling><Cell Function><Cell Membrane Lipids><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Membrane><Cellular Physiology><Cellular Process><Cellular biology><Chemicals><Collaborations><Complex><Cornu Ammonis><DNA Molecular Biology><DNA mutation><Data><Degenerative Disorder><Directed Molecular Evolution><Disease><Disorder><Dissection><Doctor of Philosophy><Engineering><Ensure><Environment><Enzyme Gene><Enzymes><Fab Fragments><Fab Immunoglobulins><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><Genetic Change><Genetic defect><Genetic mutation><Goals><Hippocampus><Image><Immunoglobulin, F(ab) Fragment><In Situ><Inositide Phospholipids><Inositol Phosphoglycerides><Inositol Phospholipids><Intracellular Communication and Signaling><Intracellular Membranes><Knowledge><Label><Ligase><Ligase Gene><Link><Lipid Binding><Lipids><MMAC1><MMAC1 protein><Mammalian Cell><Maps><Membrane><Membrane Biology><Membrane Lipids><Memory><Mentors><Molecular><Molecular Biology><Molecular Interaction><Mutated in Multiple Advanced Cancers 1><Mutation><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurosciences><Oncogenic><Organelles><Organism><PHTS gene><PHTS protein><PI(3,4,5)P3><PI3K-Alpha><PIK3-Alpha><PIK3CA><PIK3CA gene><PTEN><PTEN gene><PTEN protein><PTEN1><Pathway interactions><Peptides><Performance><Ph.D.><PhD><Phase><Phosphatase and Tensin Homolog><Phosphatase and Tensin Homolog Deleted on Chromosome 10><Phosphatidyl Inositol><Phosphatidylinositol 3-Kinase, Catalytic, 110-kD, Alpha><Phosphatidylinositol 3-Kinase, Catalytic, Alpha><Phosphatidylinositols><Phosphoinositides><Physiologic><Physiological><Plasma><Plasma Serum><Play><Property><Protein Engineering><Protein Interaction Map><Protein-Protein Interaction Map><Proteins><Proteome><Proteomics><PtdIns><Publishing><Receptor Activation><Receptor Protein><Receptor Signaling><Research><Reticuloendothelial System, Serum, Plasma><Role><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Stress><Subcellular Process><Synthetases><Technology><Therapeutic Intervention><Training><VHH><VHH antibody><Vitamin H><Work><antigen binding><antigen bound><biological signal transduction><camelid antibody><camelid based antibody><camelid derived antibody><camelid derived fragment><camelid heavy chain only Abs><camelid immunoglobulin><camelid single chain antibody><camelid variable heavy chain><cancer progression><cell biology><coenzyme R><degenerative condition><degenerative disease><design><designing><directed evolution><dynamic system><dynamical system><flow cytophotometry><genetic protein engineering><genome mutation><hippocampal><imaging><immunogen><improved><inhibitor><innovate><innovation><innovative><insight><interest><intervention therapy><lipid bound><living system><membrane structure><mu opioid receptors><mutated in multiple advanced cancers 1 protein><nanobodies><nanobody><neoplasm progression><neoplastic progression><neuronal><new technology><novel><novel technologies><p110-Alpha><pathway><phosphatase and tensin homologue on chromosome ten><phosphoinositide-3,4,5-triphosphate><pleiotropic effect><pleiotropism><pleiotropy><programs><protein design><protein protein interaction><receptor><risk mitigation><scaffold><scaffolding><sdAb><single domain antibodies><social role><spatial and temporal><spatial temporal><spatiotemporal><structural biology><tool><trafficking><tumor progression><variable heavy chain antibody><μ opioid receptors><μ-OR><μOR>
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Zhaoning Wang

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$124,688
FY 2026

Project Title

Decoding the gene regulatory network of mammalian cardiac maturation

Grant Number:

1K99HL183669-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT The mammalian heart undergoes profound transcriptional and phenotypical remodeling during postnatal development, a process known as cardiac maturation. However, the molecular mechanisms driving this transition is not fully understood, posing a major challenge in cardiac rege...

Research Terms

<Address><Advisory Committees><Automobile Driving><Basal Transcription Factor><Basal transcription factor genes><Bioinformatics><CRISPR><CRISPR/Cas system><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac development><Cardiocyte><Cardiovascular Diseases><Cell Body><Cell Culture Techniques><Cell Cycle><Cell Division Cycle><Cell Therapy><Cells><Chromatin><Clustered Regularly Interspaced Short Palindromic Repeats><Complement><Complement Proteins><Computational Biology><Computing Methodologies><Coupled><DNA Methylation><Defect><Developmental Biology><Disease><Disorder><Electrophysiology><Electrophysiology (science)><Elements><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Event><Exhibits><Faculty><Foundations><Functional RNA><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genes><Genetic Transcription><Genomic approach><Goals><Growth><Heart><Heart Diseases><Heart Muscle Cells><Heart Research><Heart myocyte><In Vitro><Induced Cardiomyocytes><Injury><Institution><Knock-in><Knowledge><Lead><Maps><Mediating><Mentors><Metabolic><Methods><Mice><Mice Mammals><Modeling><Modification><Molecular><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Murine><Mus><Natural regeneration><Neonatal><Network Analysis><Neurophysiology / Electrophysiology><Noncoding RNA><Nontranslated RNA><Outcome><Pathway Analysis><Pb element><Phase><Phenotype><Position><Positioning Attribute><Process><Progenitor Cells><RNA Expression><Regeneration><Regenerative Medicine><Regulatory Element><Reporter><Research><Research Resources><Resolution><Resources><Rest><Sampling><Solid><System><Task Forces><Technology><Therapeutic><Tissue Growth><Training><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Untranslated RNA><Validation><Variant><Variation><Withdrawal><advisory team><angiogenesis><cardiac function><cardiac repair><cardiac research><cardiogenesis><cardiomyocyte><cardiovascular disorder><career><career development><cell based intervention><cell culture><cell cultures><cell mediated intervention><cell mediated therapies><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><complementation><computational methodology><computational methods><computer based method><computer biology><computer methods><computing method><conformation><conformational><conformational state><conformationally><conformations><deep learning><deep learning based model><deep learning method><deep learning model><deep learning strategy><differentiation of pluripotent stem cells><disease model><disorder model><driving><electrophysiological><epigenetic profiling><epigenetically><epigenome><epigenomics><function of the heart><functional genomics><gene regulatory network><genomic effort><genomic strategy><global gene expression><global transcription profile><heart development><heart disorder><heart formation><heart function><heart repair><heavy metal Pb><heavy metal lead><histone modification><iPS><iPSC><iPSCs><icardiomyocytes><improved><in vivo><induced cardiac myocytes><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><injuries><innovate><innovation><innovative><innovative technologies><insight><knockin><mouse model><multiomics><multiple omics><murine model><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><noncoding><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><ontogeny><panomics><pluripotent stem cell differentiation><post-natal development><postnatal><postnatal development><programs><regenerate><regeneration potential><regenerative potential><resolutions><single cell analysis><single cell genomics><single cell technology><skills><stem cells><synergism><tenure process><tenure track><training opportunity><transcription factor><transcriptome><validations>
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Kyu Hyun Lee

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$124,205
FY 2026

Project Title

Coordinated mental simulation in the hippocampus and primary visual cortex during active behavior

Grant Number:

5K99EY036953-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY / ABSTRACT Our sensory experience goes beyond what is immediately in front of us, as evident when we recall memories or imagine future scenarios. These “mental simulations”, operationally defined as neural representation of states or stimuli that do not refer to actual present experi...

Research Terms

<Address><Affect><Algorithms><Ammon Horn><Animals><Area><Behavior><Behavioral Paradigm><Brain><Brain Nervous System><Business-Friendly Atmosphere><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chronic><Cognitive><Common Rat Strains><Communication><Computational toolkit><Cornu Ammonis><Darkness><Data><Data Analyses><Data Analysis><Devices><Distant><Electrophysiology><Electrophysiology (science)><Encephalon><Environment><Event><Eye Movements><Feedback><Foundations><Future><Geometry><Goals><Grips><Head Movements><Hippocampus><Human><Image><Immune response><Intracellular Communication and Signaling><Knowledge><Learning><Location><Measures><Memory><Mental disorders><Mental health disorders><Mentors><Mentorship><Mind><Modeling><Modern Man><Motion><Motor output><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Neurosciences><Noise><Pattern><Perception><Play><Polymers><Population><Position><Positioning Attribute><Primary visual cortex><Property><Psyche structure><Psychiatric Disease><Psychiatric Disorder><Rat><Rats Mammals><Rattus><Research><Role><Schizophrenia><Schizophrenic Disorders><Sensory><Shapes><Si element><Signal Transduction><Signal Transduction Systems><Signaling><Silicon><Source><Space Models><Stimulus><Striate Cortex><Striate area><System><Techniques><Technology><Testing><Time><Training><Travel><V1 neuron><Visual><Visual Perception><Work><area striata><biological signal transduction><business-friendly environment><career><collaborative atmosphere><collaborative environment><computational toolbox><computational tools><computational toolset><computerized tools><data interpretation><dementia praecox><density><electrophysiological><enthusiastic atmosphere><enthusiastic environment><environment enrichment><environment enrichment for laboratory animals><environmental enrichment><environmental enrichment for laboratory animals><experience><experiment><experimental research><experimental study><experiments><falls><flexibility><flexible><grasp><hippocampal><host response><imaging><immune system response><immunoresponse><innovate><innovation><innovative><insight><interactive atmosphere><interactive environment><interdisciplinary atmosphere><interdisciplinary environment><memory recall><mental><mental illness><mental imagery><network dysfunction><neural><neural circuit><neural circuitry><neural imaging><neural mechanism><neuro-imaging><neurocircuitry><neuroimaging><neurological imaging><neuromechanism><neuronal><neurophysiological><neurophysiology><optogenetics><peer-group atmosphere><peer-group environment><polymer><polymeric><psychiatric illness><psychological disorder><receptive field><recruit><schizophrenic><sensory input><simulation><skills><social role><supportive atmosphere><supportive environment><synaptic circuit><synaptic circuitry><temporal measurement><temporal resolution><time measurement><tool><visual neuroscience><visual process><visual processing><visual stimulus>
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Asim Hossain Gazi

HARVARD UNIVERSITY, CAMBRIDGE, MA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$116,802
FY 2026

Project Title

Uncertainty-Informed Decision Making for Just-in-Time Adaptive Interventions (JITAIs)

Grant Number:

5K99EB037411-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT The long-term objective of this K99/R00 application is to facilitate Dr. Asim Gazi’s development into a scientific leader in engineering and data science methods that enable personalized mobile health (mHealth) support during everyday life. The K99 phase of the project suppo...

Research Terms

<Accounting><Address><Algorithms><Applied Research><Applied Science><Area><Behavioral Sciences><Biometrics><Biometry><Biosensing Technics><Biosensing Techniques><Biosensor><Biostatistics><Blood Pressure><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Communication and Signaling><Cell Phone><Cell Signaling><Cellular Phone><Cellular Telephone><Clinic><Collaborations><Data><Data Science><Decision Making><Development><Development and Research><Disease><Disorder><Engineering><Environment><Evaluation><Expert Systems><Face><Feasibility Studies><Foundations><Goals><Grant><Health><Health Care><Health Care Technology><Health Technology><Heart Vascular><Informatics><Institution><Intelligent systems><Intervention><Intracellular Communication and Signaling><Just-in-Time Adaptive Intervention><Label><Leadership><Learning><Left><Life><Machine Learning><Measurement><Measures><Memory><Mentorship><Methodology><Methods><Mission><Mobile Phones><Modeling><NIBIB><National Institute of Biomedical Imaging and Bioengineering><Noise><Notification><Out-patients><Outcomes Research><Outpatients><Participant><Pathologic><Patients><Performance><Phase><Physiologic><Physiological><Preparation><Probability><Psychological reinforcement><Psychotherapy><R & D><R&D><Regrets><Reinforcement><Relaxation><Research><Research Methodology><Research Methods><Research Resources><Residual><Residual state><Resources><Risk><Sampling><Schools><Signal Transduction><Signal Transduction Systems><Signaling><Smoking><Source><Stress><Suicide><Suicide precaution><Suicide prevention><Therapeutic><Time><Training><Treatment Efficacy><Trust><Uncertainty><Universities><Variant><Variation><Work><Wrist><Writing><addiction><addictive disorder><behavioral health><biobehavior><biobehavioral><biological sensor><biological signal transduction><biosensing><career development><cease smoking><circulatory system><computer based prediction><computer human interaction><craving><design><designing><developmental><digital health><doubt><experience><faces><facial><fatal attempt><fatal suicide><health application><high risk><iPhone><improved><indexing><insight><intent to die><interest><intervention efficacy><learning activity><learning algorithm><learning method><learning strategies><learning strategy><m-Health><mHealth><machine based learning><machine learning based method><machine learning based model><machine learning based prediction model><machine learning based predictive model><machine learning method><machine learning methodologies><machine learning model><machine learning prediction><machine learning prediction model><machine statistical learning><man-machine interaction><mobile health><predictive modeling><preparations><prevent><prevent suicidality><prevent suicide><preventing><programs><prototype><quit smoking><research and development><research and methods><sensing data><sensor><sensor data><simulation><smart phone><smartphone><smoking cessation><standard of care><statistical and machine learning><statistics><stop smoking><success><suicidal risk><suicidality prevention><suicide intervention><suicide risk><suicides><tech development><technology development><therapeutic efficacy><therapy efficacy>
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Yiran Hou

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$116,005
FY 2026

Project Title

Molecular priming of reverse migration in neutrophil subpopulations

Grant Number:

1K99GM160698-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

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  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Chronic inflammation is a detrimental status, preventing efficient wound healing. In chronic inflammation, neutrophils remain active at the wound site after the acute inflammation period, continuing to recruit other immune cells and potentially exacerbating the wound condition. One a...

Research Terms

<Acute><Advisory Committees><Affect><Apoptosis><Apoptosis Pathway><Atlases><Auxins><Behavior><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Body Tissues><Brachydanio rerio><Burn injury><Burns><CNG channel (rod)><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Candidate Disease Gene><Candidate Gene><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chemotaxis><Chronic><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Communication><Complement><Complement Proteins><Cone><Cyclic GMP><Danio rerio><Development><Educational process of instructing><Educational workshop><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Esthesia><Gene Transcription><Genetic Models><Genetic Transcription><Genomic approach><Genomics><Goals><Guanosine Cyclic Monophosphate><Health><Hour><Human><Hydrolysis><Image><Immune><Immunes><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Immunology><Impairment><In Situ Hybridization><Individual><Infection><Inflammation><Injury><Intracellular Communication and Signaling><Investigators><Knock-in><Knock-out><Knockout><Lead><Leadership><Light><Light Signal Transduction><Marrow Neutrophil><Mediating><Medical Microbiology><Mentors><Mentorship><Metabolic Protein Degradation><Microscopy><Modeling><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Myelogenous><Myeloid><Myeloid Cells><Natural regeneration><Neutrophil Infiltration><Neutrophil Recruitment><Neutrophilic Granulocyte><Neutrophilic Infiltrate><Neutrophilic Leukocyte><Non-Polyadenylated RNA><Opsin><Pathway interactions><Pattern><Pb element><Phase><Photoradiation><Phototransduction><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Process><Programmed Cell Death><Protein Turnover><Proteins><RNA><RNA Expression><RNA Gene Products><Regeneration><Regulation><Regulatory Protein Degradation><Reporter><Research><Research Personnel><Researchers><Resolution><Ribonucleic Acid><Rod-Opsin><Role><Sensation><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Single cell seq><Site><Tail><Task Forces><Teaching><Techniques><Testing><Tissues><Training><Transcription><Transgenic Model><Universities><Upregulation><Visual Transduction><Visualization><Wisconsin><Work><Workshop><Wound Repair><Zebra Danio><Zebra Fish><Zebrafish><advisory team><biological signal transduction><burn wound><burned><cGMP><cationic channel protein (rod)><cell behavior><cellular behavior><chronic skin wound><chronic wound><complementation><conference><convention><cyclic-nucleotide gated channel><cyclic-nucleotide gated ion channels><developmental><epigenetically><fighting><gene manipulation><gene signatures><genetic approach><genetic manipulation><genetic signature><genetic strategy><genetically manipulate><genetically perturb><genomic effort><genomic strategy><genomic tools><healing><heavy metal Pb><heavy metal lead><imaging><imaging approach><imaging based approach><improved><in situ Hybridization Genetics><in situ Hybridization Staining Method><in vivo><independency><injuries><insight><knockin><migration><model building><molecular profile><molecular scale><molecular signature><neutrophil><new approaches><novel approaches><novel strategies><novel strategy><optogenetics><pathway><prevent><preventing><protein degradation><quantitative imaging><recruit><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regenerative><repair><repaired><reparative process><resolutions><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell next generation sequencing><single cell sequencing><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><spatial and temporal><spatial temporal><spatiotemporal><student mentoring><student-led learning><summit><symposia><symposium><tissue regeneration><tissue regrowth><tissue renewal><tissue repair><tissue specific regeneration><tissue wound><tool><transgenic trait><visual phototransduction><wound><wound healing><wound recovery><wound resolution><wounding><wounds>
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Kelsey Day

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$115,420
FY 2026

Project Title

Multilevel, Faith-based Intervention to Promote Rural Physical Activity

Grant Number:

1K99CA300506-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT The long-term objective of this K99/R00 application is to develop Dr. Kelsey Day’s ability to become a leader in community-based physical activity research and cancer prevention, particularly through the development of sustainable, multilevel, and participatory solutions. In...

Research Terms

<Address><American><Bible><Cancer Control><Cancer Control Science><Cancers><Chronic Disease><Chronic Illness><Church><Communities><Community Health><Comprehensive Cancer Center><Country><Data><Development><Devices><Disparities><Disparity><Economics><Educational workshop><Environment><Evidence based intervention><Exercise><Faith><Faith-based organization><Feedback><Fellowship><Focus Groups><Goals><Guidelines><Health><Health Sciences><Individual><Infrastructure><Institution><Intervention><Intervention Strategies><Investigators><Knowledge><Learning><Level of Evidence><Local Government><Malignant Neoplasms><Malignant Tumor><Measures><Mentorship><Methods><Mission><Morbidity><Personal Satisfaction><Phase><Physical activity><Postdoc><Postdoctoral Fellow><Prevalence><Process><Public Health><Qualitative Methods><Qualitative Research><Recreation><Research><Research Activity><Research Associate><Research Methodology><Research Methods><Research Personnel><Research Resources><Research Support><Researchers><Resources><Risk><Risk Reduction><Rural><Rural Community><Rural Population><Rural group><Rural people><Social support><Spirituality><Sustainable Development><Testing><Text><Text Messaging><Training><Trust><Universities><Virginia><Work><Workshop><anti-cancer research><cancer disparity><cancer health disparity><cancer prevention><cancer research><cancer risk><cancer type><cancer-related health disparity><career><chronic disorder><community based participatory research><community intervention><community led research><community level intervention><community participatory research><community partnered participatory research><community-based health><community-based intervention><design><designing><developmental><digital><disparity in cancer><economic><evidence base><faith-based intervention><fitbit><health determinants><improved><lack of physical activity><m-Health><mHealth><mHealth therapeutic><mHealth therapy><mHealth treatment><malignancy><medical college><medical schools><meeting><meeting reports><meetings><member><mhealth interventions><mobile health><mobile health intervention><mobile health therapeutic><mobile health therapy><mobile health treatment><mortality><neoplasm/cancer><participatory action research><physical inactivity><post intervention><post-doc><post-doctoral><post-doctoral trainee><programs><qualitative reasoning><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><research and methods><research associates><risk-reducing><rural area><rural dwellers><rural health disparities><rural individual><rural location><rural region><rural resident><school of medicine><short message service><skills><sms messaging><sms messaging intervention><social><social health determinants><social support network><text based intervention><text intervention><text messaging based intervention><text messaging intervention><texting><urban area><urban location><urban region><well-being><wellbeing>
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Sarah Newmeyer Price

WAKE FOREST UNIVERSITY HEALTH SCIENCES, WINSTON-SALEM, NC

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$112,342
FY 2026

Project Title

Refining Cognitive Behavioral Therapy for Insomnia in Lung Cancer Survivors: Enhancing Feasibility, Acceptability, and Symptom Management

Grant Number:

5K99CA297014-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY These is a growing population of lung cancer survivors (LCS) in the United States, estimated at nearly 655,000, many of whom experience disproportionate symptom burden compared to other cancer survivors. Among LCS, bothersome symptoms such as insomnia, fatigue, pain, anxiety, depress...

Research Terms

<Address><Adherence><Advocate><Anxiety><Applications Grants><Area><Attention><Award><Behavioral><Breathlessness><COPD><Cancer Control><Cancer Control Science><Cancer Survivor><Cancers><Caring><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clinical><Cognition Therapy><Cognitive Psychotherapy><Cognitive Therapy><Cognitive treatment><Communities><Complex><Consultations><Coughing><Data><Development><Dyspnea><Education><Educational aspects><Face><Fatigue><Future><Goals><Grant Proposals><Hybrids><Impairment><Individual><Insomnia><Insomnia Disorder><Intervention><Interview><Investigators><Lack of Energy><Length><Literature><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Measures><Mental Depression><Mentors><Meta-Analysis><Methods><Modification><Outcome><Pain><Painful><Participant><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Patients><Persons><Phase><Physical Function><Population><Price><Protocol><Protocols documentation><Pulmonary Cancer><Pulmonary malignant Neoplasm><QOL><Quality of life><Randomized><Randomized, Controlled Trials><Relaxation><Research><Research Personnel><Researchers><Respiratory Signs and Symptoms><Risk Factors><Severities><Sleep><Sleep disturbances><Sleeplessness><Social Functioning><Supportive Therapy><Supportive care><Survey Instrument><Surveys><Symptom Burden><Symptoms><Testing><Training><United States><aberrant sleep><acceptability and feasibility><airway symptom><arm><associated symptom><career><chronic obstructive pulmonary disorder><circadian><clinical significance><clinically significant><co-morbid><co-morbid symptom><co-morbidity><co-occuring symptom><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><comorbid symptom><comorbidity><concurrent symptom><consultation><cooccuring symptom><depression><develop therapy><developmental><disrupted sleep><disturbed sleep><efficacy outcomes><efficacy trial><experience><faces><facial><feasibility testing><feasibility trial><function socially><functioning social><impaired sleep><implementation facilitation><improve symptom><improved><intervention development><intervention refinement><irregular sleep><lung cancer><lung function><malignancy><malleable risk><manage symptom><modifiable risk><multidisciplinary><multiphase optimization strategy><neoplasm/cancer><physical conditioning><physical health><pricing><primary outcome><psychological distress><psychosocial><pulmonary><pulmonary function><randomisation><randomization><randomized control trial><randomly assigned><respiratory><respiratory symptom><secondary outcome><sleep disruption><sleep dysregulation><sleep health><sleep hygiene><sleep wellness><sleep/wake disruption><sleep/wake disturbance><social stigma><stigma><symptom association><symptom comorbidity><symptom improvement><symptom management><symptomatic improvement><therapy development><therapy optimization><treatment development><treatment optimization><virtual>
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Marisa Ann Patti

DREXEL UNIVERSITY, PHILADELPHIA, PA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$111,199
FY 2026

Project Title

Investigating the Role of Phthalates, Phenols, and Their Sources on Phenotypic Variability in Autism

Grant Number:

1K99ES038217-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/3/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Autism is a neurodevelopmental disorder impacting 1 in 36 children in the US. Children with autism often experience multi-morbidity of other neurodevelopmental disorders (NDDs) and physical health outcomes like obesity and asthma at higher rates than typically developing pee...

Research Terms

<0-11 years old><3 year old><3 years of age><ASD><Address><Asthma><Asthma in Children><Autism><Autism Diagnosis><Autistic Disorder><Award><Biological Markers><Bronchial Asthma><Carbol><Carbolic Acid><Chemical Exposure><Chemicals><Child><Child Health><Child Youth><Childhood Asthma><Children (0-21)><Cognition><Cohort Studies><Data><Data Collection><Data Set><Diet><Early Infantile Autism><Endocrine Disrupter><Endocrine Disrupting Chemicals><Endocrine Disruptors><Endocrine disrupting agent><Environmental Health><Environmental Health Science><Epidemiology><Exposure to><Frequencies><Funding><Future><General Population><General Public><Gestation><Goals><Grant><Health><Heterogeneity><High Prevalence><Hydroxybenzene><Individual><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Investigation><Kanner's Syndrome><Knowledge><Lead><Maternal Exposure><Maternal Nutrition><Maternal diet><Measures><Mediating><Mediation><Mentorship><Multiple types of exposure><NIH><National Institutes of Health><Negotiating><Negotiation><Neighborhoods><Neurodevelopmental Disorder><Neurologic><Neurological><Neurological Development Disorder><Obesity><Outcome><Participant><Pattern><Pb element><Pediatric asthma><Phenols><Phenotype><Population><Pregnancy><Prevalence><Protocol><Protocols documentation><Questionnaires><Research><Research Design><Risk><Risk Reduction><Role><Rural><Sampling><Source><Study Type><Subgroup><Time><Training><United States National Institutes of Health><Urban Health><Urbanicity><Work><adiposity><age 3><age 3 years><autism spectral disorder><autism spectrum disorder><autistic children><autistic spectrum disorder><bio-markers><biologic marker><biomarker><child adiposity><child obesity><childhood adiposity><childhood obesity><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><cohort research study><cohort survey><corpulence><data harmonization><dietary><diets><endocrine disrupting compound><epidemiologic><epidemiological><experience><exposed in utero><exposure research><exposure science><fetal exposure><harmonized data><heavy metal Pb><heavy metal lead><improved><in utero exposure><intellectual and developmental disability><intra-uterine environmental exposure><intrauterine environmental exposure><kids><limited intellectual functioning><maternal nutrition during pregnancy><mother nutrition><multi-exposure><multimorbidity><multiple chronic conditions><multiple exposures><multitude of exposure><neurodevelopmental disease><obese children><obesity during childhood><obesity in children><pediatric obesity><peer><personal care products><phthalates><physical conditioning><physical health><prenatal><prenatal exposure><prenatally exposed><programs><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><risk-reducing><social role><study design><three year old><three years of age><trait><unborn><urban dwelling><urinary><various exposures><various types of exposure><youngster>
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Talia Lee Hatkevich

DUKE UNIVERSITY, DURHAM, NC

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$107,458
FY 2026

Project Title

Mechanisms of Double Strand Break Repair in Fetal Male Germ Cells

Grant Number:

5K99HD117011-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2025

End Date:

4/30/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Male germ cells (MGCs) are precursors to spermatogonial stem cells (SSCs), a stem cell population that both self-renews and differentiates, supplying spermatozoa for the entirety of a male’s reproductive lifespan. Therefore, any genomic perturbation in MGCs caused by inaccurate DNA d...

Research Terms

<Affect><Allelic Loss><Apoptosis><Apoptosis Pathway><Assay><Bioassay><Bioinformatics><Biological><Biological Assay><Birth><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cannot achieve a pregnancy><Cas nuclease technology><Cell Body><Cell Cycle Arrest><Cell Cycle Stage><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Chromosomal Loss><Chromosomal Rearrangement><Chromosomes><Chronology><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complex><Couples><Creativeness><DNA><DNA Damage><DNA Damage Repair><DNA Injury><DNA Repair><DNA mutation><Dangerousness><Data><Defect><Deletion of DNA Sequences><Deoxyribonucleic Acid><Developing fetus><Development><Development Plans><Development and Research><Difficulty conceiving><Doctor of Philosophy><Double Strand Break Repair><Embryo><Embryonic><Ensure><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Expression Signature><Fecundability><Fecundity><Fertility><Fetal Development><Future><G0 Phase><G0 state><Gametes><Gene Expression Profile><Gene Transcription><GeneHomolog><Generations><Genetic Change><Genetic Models><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Genomics><Germ Cells><Germ Lines><Germ-Line Cells><Heritability><Homolog><Homologous Gene><Homologue><Hour><Human><Immunofluorescence><Immunofluorescence Immunologic><Infertility><Investigators><Kinetics><Knowledge><Laboratories><Loss of Heterozygosity><Male reproductive health><Mediating><Mentors><Mice><Mice Mammals><Modern Man><Modification><Molecular><Murine><Mus><Mutation><NHEJ><Non-Homologous End Joining><Non-homologous DNA End Joining><Nonhomologous DNA End Joining><Nonhomologous End Joining><Parturition><Pathway interactions><Ph.D.><PhD><Phase><Probability><Process><Programmed Cell Death><Proteins><Proteome><R & D><R&D><RNA Expression><Reproduction><Reproductive Cells><Reproductive Health><Research><Research Personnel><Researchers><Role><Scientist><Sequence Deletion><Sex Cell><Sister Chromatid><Somatic Cell><Sperm><Sperm stem cell><Spermatocytes><Spermatozoa><Spermiocytes><Stem Cell Development><Subcellular Process><Testing><Time><Training><Transcript><Transcription><Transgenic Mice><Universities><Unscheduled DNA Synthesis><Upregulation><Work><biologic><creativity><design><designing><developmental><epigenetically><experience><fertility cessation><fertility loss><fetal><gene expression pattern><gene expression signature><genome integrity><genome mutation><genomic deletion><genomic integrity><homologous recombination><improved><in vivo><infertile><initial cell><innovate><innovation><innovative><insight><large data sets><large datasets><life span><lifespan><male><male germ cells><male reproductive functions><male reproductive tract health><mens reproductive functions><mens reproductive health><mouse genetics><mutant><novel><pathway><post-doctoral training><postnatal><progenitor cell development><progenitor cell pool><progenitor cell population><progenitor development><progenitor pool><progenitor population><programs><repair><repaired><reproductive><reproductive health in men><research and development><response><scRNA sequencing><scRNA-seq><self-renew><self-renewal><sexual cell><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell genomics><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><sperm cell><sperm progenitor><spermatogonia cell><spermatogonia progenitor><spermatogonia stem cells><spermatogonial cell><spermatogonial progenitor><spermatogonial stem cells><stem and progenitor cell development><stem and progenitor cell population><stem cell pool><stem cell population><transcriptional profile><transcriptional signature><transcriptomics><zoosperm><♂>
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Ndenkeh Nforbewing Jackson Jr

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$93,799
FY 2026

Project Title

Using Client Centered Care Coordination to Improve HIV Treatment Outcomes among Men with Highest Incidence of HIV in the United States

Grant Number:

5K99MD020601-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/18/2025

End Date:

1/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Career Goal: My career goal is to become an independent academic researcher conducting high-impact scientific studies that aim to improve HIV treatment outcomes in the United States (U.S.). This NIH Pathway to Independence Award (K99/R00) will provide the training and resources that ...

Research Terms

<AIDS Virus><AIDS care><AIDS prevention><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Active Follow-up><Address><Adherence><American male><American man><American men><Anti-Retroviral Agents><Appointment><Award><Behavior><Caring><Cities><Client><Clinic><Clinical><Complex><Drug Costs><Drug Side Effects><Drugs><Education><Educational aspects><Educational process of instructing><Effectiveness of Interventions><Emotional well being><Employment><Epidemic><Feels well><Focus Groups><Generalized Growth><Goals><Grant><Growth><HIV><HIV Care><HIV Prevention><HIV burden><HIV diagnosis><HIV disease burden><HIV disease transmission><HIV epidemic burden><HIV global burden><HIV health burden><HIV incidence><HIV individuals><HIV infected individuals><HIV infected persons><HIV infection spread><HIV infection transmission><HIV intervention><HIV medical care><HIV patient care><HIV people><HIV positive individuals><HIV positive people><HIV related care><HIV related patient care><HIV spread><HIV therapeutic><HIV therapy><HIV transmission><HIV treatment><HIV viral transmission><HIV-1 care><HIV-1 incidence><HIV-1 infection incidence><HIV-1 intervention><HIV-1 prevention><HIV-1 spread><HIV-1 therapeutic><HIV-1 therapy><HIV-1 transmission><HIV-1 treatment><HIV-1 virus transmission><HIV/AIDS incidence><HIV/AIDS prevention><HIV/AIDS transmission><Health><Health Care><Health Care Providers><Health Insurance><Health Personnel><Health system><Housing><Human Immunodeficiency Virus Type 1 transmission><Human Immunodeficiency Virus therapy><Human Immunodeficiency Virus treatment><Human Immunodeficiency Viruses><Hybrids><Individual><Injectable><Injections><Insurance Coverage><Insurance Status><Intervention><Interview><Investigators><Knowledge><LAV-HTLV-III><Learning><Learning Skill><Logic><Lymphadenopathy-Associated Virus><Maintenance><Measures><Medication><Mental disorders><Mental health disorders><Mentors><Mentorship><Methods><Modeling><NIH><National Institutes of Health><Nature><Normal mental condition><Normal mental state><Normal psyche><Outcome><PLWH><PWH><Participant><Pathway interactions><Personal Satisfaction><Persons><Pharmaceutical Preparations><Phase><Population><Postdoc><Postdoctoral Fellow><PrEP><Prevent HIV><Prevention Research><Process><Psychiatric Disease><Psychiatric Disorder><Psychological Well Being><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized, Controlled Trials><Reporting><Research><Research Associate><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Resources><Schedule><Scientist><Self Determination><Sense of well-being><Social support><Spinal Column><Spine><Substance Use Disorder><Teaching><Time><Tissue Growth><Training><Transmission><Transportation><Treatment outcome><U.S. Males><US Men><US male><United States><United States National Institutes of Health><Vertebral column><Viral><Viral Burden><Viral Load><Viral Load result><Virus-HIV><Wait Time><Well in self><Writing><active followup><anti-retroviral><antiretroviral therapy><antiretroviral treatment><backbone><barrier to care><barrier to health care><barrier to treatment><care as usual><care coordination><care of HIV-1><career><career development><coordinating care><cost effectiveness><digital><drug adherence><drug compliance><drug/agent><efficacy/implementation trial><emotional wellbeing><emotional wellness><experience><experiences among men><follow up><follow-up><followed up><followup><food insecure><food insecurity><food scarcity><global health><health care personnel><health care worker><health goals><health insurance plan><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><human immunodeficiency virus burden><human immunodeficiency virus care><human immunodeficiency virus global burden><human immunodeficiency virus incidence><human immunodeficiency virus transmission><implementation intervention><implementation research><implementation science><implementation strategy><improved><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><informant><interest><intervention design><low food security><male experience><males in America><males in the U.S.><males in the US><males in the USA><males in the United States><medical care providers><medical personnel><medication adherence><medication compliance><men><men in America><men in the U.S.><men in the US><men in the USA><men in the United States><men's experience><mental illness><mental well-being><mental wellbeing><mental wellness><multidisciplinary><obstacle to care><obstacle to health care><ontogeny><oral HIV><parity><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><post-doc><post-doctoral><post-doctoral trainee><pre-exposure prophylaxis><prevent><prevent AIDS><prevent human immunodeficiency virus><preventing><primary outcome><psychiatric illness><psychologic><psychological><psychological disorder><psychological wellbeing><psychological wellness><psychosocial><public health relevance><randomized control trial><research associates><response><secondary outcome><self wellness><sense of wellbeing><skills><social culture><social support network><socio-cultural><socio-economic><socio-economically><sociocultural><socioeconomically><socioeconomics><spread of human immunodeficiency virus><strategies for implementation><structural determinants><structural factors><substance use and disorder><theories><therapy design><tool><transmission process><treat HIV><treat Human Immunodeficiency Virus><treatment adherence><treatment as usual><treatment compliance><treatment design><treatment provider><treatment research><trial design><usual care><well-being><wellbeing>
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Neelima Thottappillil

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$93,085
FY 2026

Project Title

Elucidating the role of the tunica adventitia resident progenitor cells in vascular calcification

Grant Number:

1K99HL179387-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Vascular calcification serves as the primary risk factor for predicting cardiovascular events. It involves arterial calcification, an actively regulated process mediated by cells, resembling physiological biomineralization but with impaired resorption. The vessel wall contains “calci...

Research Terms

<APC receptor><Ablation><Adipose tissue><Adventitia><Adventitial Cell><Arteries><Autoregulation><B220><Blood Vessels><CD146><CD146 protein><CD31><CD34><CD34 gene><CD45><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Calcified><Calcinosis><Calcium><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cell surface><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular biology><Chicken Homolog of Gicerin><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Co-culture><Cocultivation><Coculture><Coculture Techniques><Data><Death Rate><Deposit><Deposition><Development><Disease><Disorder><EPCR><EPCR gene><Ectopic Ossification><Endothelial Cells><Endothelial protein C receptor><Environment><Event><Exhibits><Expression Signature><Fatty Tissue><GP180><Gene Expression Profile><Genes><Genetic><Goals><HPCA1><Heart Vascular><Heterotopic Ossification><Homeostasis><Human><Immunologic Subtyping><Immunophenotyping><Impairment><In Vitro><Infection><Inflammation><Intracellular Communication and Signaling><KO mice><Knock-out Mice><Knockout Mice><Knowledge><LY5><Leiomyocyte><Lineage Tracing><Location><MCAM><MCAM gene><MUC18><Maps><Mediating><Melanoma Adhesion Molecule><Melanoma-Associated Glycoprotein MUC18><Methods><Mice><Mice Mammals><Microanatomy><Microscopic Anatomy><Minerals><Modeling><Modern Man><Murine><Mus><Nephrectomy><Null Mouse><Osteoblasts><PECAM1><PECAM1 gene><PTPRC><PTPRC gene><Pathologic><Pathologic Calcification><Pathologic Ossification><Pathological Ossification><Pathology><Pathway interactions><Pericapillary Cell><Pericytes><Perivascular Cell><Phase><Physiologic><Physiological><Physiological Homeostasis><Position><Positioning Attribute><Predictive Factor><Process><Progenitor Cells><Proteins><RNA Seq><RNA sequencing><RNAseq><Reaction><Reporter><Research><Risk Factors><Role><Rouget Cells><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Skeletal bone><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Stem Cell like><Stimulus><Subcellular Process><T200><Testing><Training><Tunica Adventitia><Validation><Vascular aging><Vascular calcification><activated protein C receptor><adipose><biological signal transduction><biomineralization><calcification><career><cell biology><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><circulatory system><comparative><developmental><endothelial cell protein C receptor><gene expression pattern><gene expression signature><glycoprotein MUC18><human tissue><improved><inhibitor><injury and repair><interest><knock-down><knockdown><melanoma cell adhesion molecule><migration><mineralization><mortality rate><mouse model><murine model><osteogenic><pathway><progenitor><progenitor capacity><progenitor cell like><progenitor cell niche><progenitor niche><progenitor-like><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial integration><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><stem and progenitor cell niche><stem cell characteristics><stem cell niche><stem cells><stem-like><stemness><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><therapeutically effective><transcriptional profile><transcriptional signature><transcriptome sequencing><transcriptomic sequencing><transcriptomics><transdifferentiation><validations><vascular><vasculature aging><white adipose tissue><yellow adipose tissue>
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Elora Midavaine

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$53,998
FY 2026

Project Title

Sex-dependent control of nociception by meningeal regulatory T cells

Grant Number:

3K99NS142248-01S1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2025

End Date:

7/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary This is an application for an administrative supplement to the K99 award granted to myself, Dr. Élora Midavaine, a postdoctoral fellow at the University of California - San Francisco. Women are up to three times more likely to experience chronic pain compared to men. Both immune cell...

Research Terms

<Absence of pain sensation><Absence of sensibility to pain><Administrative Supplement><Advisory Committees><Afferent Neurons><Analgesia Tests><Autoregulation><Award><Behavioral><Body Tissues><California><Caring><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell secretion><Cells><Cellular Secretion><Differences between sexes><Differs between sexes><Endocrine Gland Secretion><Exhibits><Feels no pain><Female><Gestation><Gonadal Steroid Hormones><Grant><Homeostasis><Hormones><Hypersensitivity><Immune><Immune response><Immune system><Immunes><Immunology><In vivo two-photon calcium imaging><Intracellular Communication and Signaling><Investigators><Mediating><Medulla Spinalis><Meningeal><Meninges><Mentors><Mice><Mice Mammals><Mothers><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuroimmune><Neurons><No sensitivity to pain><Nociception><Nociception Tests><Nulliparas><Nulliparity><Nulliparous><Opiates><Opioid><Pain><Pain Assessment><Pain Control><Pain Measurement><Pain Therapy><Pain management><Pain measure><Painful><Pathway interactions><Phase><Physiological Homeostasis><Play><Postdoc><Postdoctoral Fellow><Pregnancy><Receptor Protein><Regulation><Regulatory T-Lymphocyte><Research><Research Associate><Research Personnel><Researchers><Role><San Francisco><Sensory Neurons><Sex Differences><Sex Hormones><Sex Steroid Hormones><Sexual differences><Signal Transduction><Signal Transduction Systems><Signaling><Site><Spinal Cord><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Subsets><Task Forces><Therapeutic Hormone><Tissues><Treg><Universities><Woman><advisory team><analgesia><antinociception><antinociceptive><biological signal transduction><career development><chronic pain><delta opioid receptor><endogenous opiate><endogenous opioids><experience><global gene expression><global transcription profile><gonadal steroids><host response><human data><immune system response><immunoneurology><immunoresponse><in vivo calcium imaging><men><meninge><mouse genetics><neuroimmunology><neuronal><nociceptive><novel><offspring><pain assay><pain intervention><pain sensitivity><pain signal><pain treatment><pathway><post-doc><post-doctoral><post-doctoral trainee><receptor><regulatory T-cells><research associates><sex><sex based differences><sex dimorphism><sex steroid><sex-dependent differences><sex-related differences><sex-specific differences><sexual dimorphism><sexually dimorphic><social role><thymus derived lymphocyte><transcriptome><transcriptomics><δ OR><δ ORs><δ opioid receptors><δ-OR><δ-ORs><δOR><δORs><♀>
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Karen G. Martinez Gonzalez

UNIVERSITY OF PUERTO RICO MED SCIENCES, SAN JUAN, PR

Good lead · 52/100
Training-friendly
Above-average budget
Active award
$516,903
FY 2026

Project Title

Clinical and Translational Research Education and Career Development at the University of Puerto Rico (CRECD-UPR)

Grant Number:

5R25MD007607-24

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/24/2002

End Date:

12/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award size is strong enough to merit immediate review.

Project Abstract

The Clinical and Translational Research Education and Career Development at the University of Puerto Rico (CRECD-UPR) program at the University of Puerto Rico Medical Sciences Campus (UPR-MSC) has a documented track record of increasing the workforce in clinical and translational research on health ...

Research Terms

<AIDS/HIV><Address><Admission><Admission activity><Area><Audiology><Award><Cancers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Clinic><Clinical><Clinical Research><Clinical Sciences><Clinical Study><Collaborations><Curriculum><Decrease health disparities><Dental><Dentistry><Development Plans><Diabetes Mellitus><Discipline><Discipline of Nursing><Education><Educational Curriculum><Educational aspects><Enrollment><Ensure><Funding><Goals><Grant><HIV/AIDS><Health><Health Care Professional><Health Disparities Research><Health Professional><Health disparities related research><Health disparity mitigation><Health disparity reduction><Infant><Infrastructure><Institution><Intervention><Investigators><Justice><K-Awards><K-Series Research Career Programs><Knowledge><Leadership><Learning><Lower health disparities><Malignant Neoplasms><Malignant Tumor><Master of Science><Master's Degree><Maternal Health><Medical><Medicine><Mental Health><Mental Hygiene><Mentors><Mentorship><Methodology><Mitigate health disparities><NIH><National Institutes of Health><Nursing><Nursing Field><Nursing Profession><Occupational Therapy><Oral health><Outcome><Peer Review><Pharmacies><Pharmacy facility><Pilot Projects><Population><Postdoc><Postdoctoral Fellow><Productivity><Program Evaluation><Psychological Health><Psychology><Publications><Publishing><Puerto Rico><Qualifying><Reduce health disparities><Research><Research Associate><Research Career Program><Research Personnel><Research Support><Research Training><Researchers><Science><Scientific Publication><Scientist><Structure><Training><Training Activity><Training Programs><Translational Research><Translational Science><United States National Institutes of Health><Universities><Work><academic program><career development><clinical development><dental health><diabetes><disparity in health><education research><enroll><expectation><experience><health disparities science><health disparity><health training><improved><innovate><innovation><innovative><lesson plans><malignancy><meeting><meetings><neoplasm/cancer><next generation><novel><patient oriented research><patient oriented study><pilot study><population health><post-doc><post-doctoral><post-doctoral trainee><precision medicine><precision-based medicine><programs><recruit><research associates><skills><success><timeline><training module><translation research><translational investigation><translational investigator><translational researcher><translational scientist>
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Barbara Segarra-Vazquez

UNIVERSITY OF PUERTO RICO MED SCIENCES, SAN JUAN, PR

Good lead · 52/100
Training-friendly
Above-average budget
Active award
$516,903
FY 2026

Project Title

Clinical and Translational Research Education and Career Development at the University of Puerto Rico (CRECD-UPR)

Grant Number:

5R25MD007607-24

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/24/2002

End Date:

12/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award size is strong enough to merit immediate review.

Project Abstract

The Clinical and Translational Research Education and Career Development at the University of Puerto Rico (CRECD-UPR) program at the University of Puerto Rico Medical Sciences Campus (UPR-MSC) has a documented track record of increasing the workforce in clinical and translational research on health ...

Research Terms

<AIDS/HIV><Address><Admission><Admission activity><Area><Audiology><Award><Cancers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Clinic><Clinical><Clinical Research><Clinical Sciences><Clinical Study><Collaborations><Curriculum><Decrease health disparities><Dental><Dentistry><Development Plans><Diabetes Mellitus><Discipline><Discipline of Nursing><Education><Educational Curriculum><Educational aspects><Enrollment><Ensure><Funding><Goals><Grant><HIV/AIDS><Health><Health Care Professional><Health Disparities Research><Health Professional><Health disparities related research><Health disparity mitigation><Health disparity reduction><Infant><Infrastructure><Institution><Intervention><Investigators><Justice><K-Awards><K-Series Research Career Programs><Knowledge><Leadership><Learning><Lower health disparities><Malignant Neoplasms><Malignant Tumor><Master of Science><Master's Degree><Maternal Health><Medical><Medicine><Mental Health><Mental Hygiene><Mentors><Mentorship><Methodology><Mitigate health disparities><NIH><National Institutes of Health><Nursing><Nursing Field><Nursing Profession><Occupational Therapy><Oral health><Outcome><Peer Review><Pharmacies><Pharmacy facility><Pilot Projects><Population><Postdoc><Postdoctoral Fellow><Productivity><Program Evaluation><Psychological Health><Psychology><Publications><Publishing><Puerto Rico><Qualifying><Reduce health disparities><Research><Research Associate><Research Career Program><Research Personnel><Research Support><Research Training><Researchers><Science><Scientific Publication><Scientist><Structure><Training><Training Activity><Training Programs><Translational Research><Translational Science><United States National Institutes of Health><Universities><Work><academic program><career development><clinical development><dental health><diabetes><disparity in health><education research><enroll><expectation><experience><health disparities science><health disparity><health training><improved><innovate><innovation><innovative><lesson plans><malignancy><meeting><meetings><neoplasm/cancer><next generation><novel><patient oriented research><patient oriented study><pilot study><population health><post-doc><post-doctoral><post-doctoral trainee><precision medicine><precision-based medicine><programs><recruit><research associates><skills><success><timeline><training module><translation research><translational investigation><translational investigator><translational researcher><translational scientist>
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Chang-Yu Alex Chen

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$176,040
FY 2026

Project Title

The effect of aging on cDC1 function and CD8 T cell immunity in tumors

Grant Number:

5K99CA296769-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ ABSTRACT Aging is a well-established risk factor for the development of cancer and is associated with a gradual decline in immune function. Studies have indicated that this age-related decline in immune function can hamper the effectiveness of CD8+ T cell immunity and restrict the r...

Research Terms

<Address><Advisory Committees><Affect><Age><Aging><Antigen Presentation><Antigens><Assay><Bioassay><Biological Assay><Biopsy><Blood><Blood Reticuloendothelial System><Bone Marrow><Bone Marrow Reticuloendothelial System><Bp50><CD40><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CD86><CD86 gene><CDW40><CRG-2><CXCL10><CXCL10 gene><CXCL9><CXCL9 gene><Cancer Control><Cancer Control Science><Cancer Patient><Cancers><Cell Body><Cell Communication><Cell Count><Cell Function><Cell Interaction><Cell Isolation><Cell Number><Cell Physiology><Cell Process><Cell Segregation><Cell Separation><Cell Separation Technology><Cell secretion><Cell-to-Cell Interaction><Cells><Cellular Function><Cellular Immune Function><Cellular Physiology><Cellular Process><Cellular Secretion><Cellular biology><Chemotactic Cytokines><Collaborations><Complement><Complement Proteins><Complex><Data><Defect><Dendritic Cells><Development><Dysfunction><Effectiveness><Elderly><Environment><Exhibits><FLK2><FLT 3 Ligand><FLT3><FLT3 gene><FLT3 ligand><FLT3L><FLT3LG><FLT3LG gene><FMS-Related Tyrosine Kinase 3 Ligand Gene><FMS-Related Tyrosine Kinase-3 Ligand><FMS-like tyrosine kinase 3><Fms-Related Tyrosine Kinase 3><Functional disorder><Goals><Homologous Chemotactic Cytokines><Human><Humig><IFI10><INP10><IP-10><Image><Immune><Immune mediated therapy><Immune response><Immunes><Immunity><Immunologically Directed Therapy><Immunology><Immunotherapy><Impairment><Injections><Intercrines><Intervention><Investigators><Knowledge><Lymph Node Reticuloendothelial System><Lymph node proper><Lymphatic nodes><MGC9013><MIG Gene><MOB-1><Malignant Melanoma><Malignant Neoplasms><Malignant Tumor><Melanoma><Melanoma Tumor><Melanoma patient><Mentors><Mentorship><Mice><Mice Mammals><Modern Man><Molecular><Monitor><Murine><Mus><Myelogenous><Myeloid><Nature><Organ><PD 1><PD-1><PD-L1 blockade><PD1><PDL1 blockade><Personalized medical approach><Phase><Physiopathology><Play><Production><Publishing><Rejuvenation><Research><Research Personnel><Researchers><Risk><Risk Factors><Role><SCYB10><SCYB9><SIS cytokines><STK-1 kinase><STK1><STK1-ligand><Sorting><Stem Cell Tyrosine Kinase 1><Stem Cell like><Subcellular Process><T cell receptor repertoire sequencing><T cell receptor sequencing><T cell response><T-Cells><T-Lymphocyte><T8 Cells><T8 Lymphocytes><TCR repertoire sequencing><TCR sequencing><TCR-seq><TCRseq><TNFRSF5><TNFRSF5 gene><Task Forces><Techniques><Testing><Therapeutic><Training><Tumor Necrosis Factor Receptor Superfamily Member 5 Gene><Tumor Promotion><Tumor growth in melanoma><Veiled Cells><Work><advanced age><advisory team><age associated><age associated decline><age associated effects><age correlated><age dependent><age dependent decline><age effect><age linked><age related><age related decline><age related effects><age specific><aged><ages><aging effect><anti-PD-L1 blockade><cancer microenvironment><career><cell biology><cell sorting><chemoattractant cytokine><chemokine><complementation><crg-10><cytokine><decline with age><developmental><draining lymph node><elderly patient><exhaust><experiment><experimental research><experimental study><experiments><fetal liver kinase-2><fetal liver kinase-3><flk2 ligand><flk2-flt3 ligand><flt3 ligand protein><gIP-10><geriatric><host response><imaging><immune function><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunogen><immunoresponse><impact of age><improved><in vivo><individualized approach><influence of age><innovate><innovation><innovative><insight><lymph gland><lymph nodes><lymphnodes><malignancy><melanoma cancer model><melanoma model><melanoma tumor model><mouse model><multiomics><multiple omics><murine model><neoplasm/cancer><novel><older patient><p50><panomics><pathophysiology><patients suffering from melanoma><patients with melanoma><personalized approach><precision approach><prevent><preventing><progenitor capacity><progenitor cell differentiation><progenitor cell like><progenitor differentiation><progenitor-like><progenitor-like cell><programmed cell death 1><programmed cell death protein 1><programmed death 1><proliferation capability><proliferation capacity><proliferation potential><proliferative capability><proliferative capacity><proliferative potential><recruit><regional lymph node><response><senior citizen><skills><sle2><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><stem and progenitor differentiation><stem cell characteristics><stem cell differentiation><stem cell tyrosine kinase 1 ligand><stem-like><stem-like cell><stemness><systemic lupus erythematosus susceptibility 2><tailored approach><thymus derived lymphocyte><transcriptomics><tumor><tumor growth><tumor microenvironment>
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Maxime F. Chevee

VANDERBILT UNIVERSITY, Nashville, TN

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$174,246
FY 2026

Project Title

Circuit mechanisms underlying inflexible habitual behaviors following chronic cocaine use

Grant Number:

5K99DA060930-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT K99 research: Habits are inflexible behaviors that occur independently of the outcome of a given action. In cocaine use disorder, habits are often discussed in the context of drug use; however, equally important is the impact of cocaine consumption on habitual behaviors that...

Research Terms

<Adaptive Behaviors><Affect><Animals><Award><Behavior><Behavior Control><Behavioral><Behavioral Manipulation><Calcium><Cell Body><Cells><Chronic><Clinical><Cocaine><Cocaine use disorder><Computer Analysis><Consumption><Corpus Striatum><Corpus striatum structure><DA Neuron><Data><Decision Making><Dimensions><Dopamine><Dopamine neuron><Dorsal><Drug usage><Drugs><Dysfunction><Ensure><Fiber><Functional disorder><Funding><Glutamates><Goals><Grant><Habits><History><Human><Hydroxytyramine><Image><Impairment><In vivo two-photon calcium imaging><Individual><L-Glutamate><Learning><Link><Medication><Mentorship><Mice><Mice Mammals><Microscope><Modeling><Modern Man><Movement><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurosciences><Optics><Outcome><Pattern><Pharmaceutical Preparations><Phase><Photometry><Physiopathology><Positive Reinforcements><Prevalence><Primates><Primates Mammals><Process><Recording of previous events><Research><Resolution><Rodent Model><Saccharose><Saline><Saline Solution><Stimulus><Striate Body><Striatum><Structure><Sucrose><Testing><Time><Training><Writing><adaptation behavior><adaptive behavior><adaptive learning><addiction><addictive disorder><behavioral control><behavioral impairment><body movement><career development><cell type><cocaine exposure><cocaine self-administration><cocaine use><cocaine-exposed><computational analyses><computational analysis><computer analyses><design><designing><dopaminergic neuron><drug use><drug/agent><experiment><experimental research><experimental study><experiments><exposed to cocaine><exposure to cocaine><glutamatergic><histories><imaging><imaging approach><imaging based approach><impaired behavior><in vivo calcium imaging><kinematic model><kinematics><motor control><neural><neural circuit><neural circuitry><neurocircuitry><neuronal><non-drug><nondrug><optical><optogenetics><pathophysiology><resolutions><response><self-administer cocaine><sensor><skills><striatal><success><synaptic circuit><synaptic circuitry><tool>
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Carla Golden

NEW YORK UNIVERSITY, NEW YORK, NY

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$169,489
FY 2026

Project Title

Estrogenic regulation of neuromodulators and temporal discounting

Grant Number:

1K99DA062326-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/29/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary To survive, animals must learn to maximize reward and minimize the cost of time. The value of a reward is discounted according to its anticipated delay, termed temporal discounting, and the rate of this depreciation for money, food, and sex varies with hormonal fluctuations over the...

Research Terms

<5-HT><5-HT pathway><5-HT system><5-Hydroxytryptamine><5HT><5HT transporter><5HTT protein><Address><Affect><Animals><Autoregulation><Axon Terminals><Basic Research><Basic Science><Behavior><Behavioral><Behavioral Paradigm><Biosensor><Brain><Brain Nervous System><Brain region><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Common Rat Strains><Complex><Computer Models><Computerized Models><Cues><DA Neuron><DAT dopamine transporter><Decision Making><Depreciation><Dopamine><Dopamine neuron><Dopaminergic Cell><Electrophysiology><Electrophysiology (science)><Encephalon><Endocrine Gland Secretion><Enteramine><Environment><Estrogen Receptors><Estrogenic Agents><Estrogenic Compounds><Estrogens><Estrus><Female><Fiber><Food><Foundations><Future><Gene Transcription><Genetic Transcription><Gonadal Hormones><Hippophaine><Homeostasis><Hormonal><Hormone use><Hormones><Human><Hydrogen Oxide><Hydroxytyramine><Intermediary Metabolism><Intracellular Communication and Signaling><Laboratories><Learning><Measures><Menstrual cycle><Mental Processes><Mental disorders><Mental health disorders><Mentorship><Mesencephalon><Messenger RNA><Metabolic Processes><Metabolism><Mid-brain><Midbrain><Midbrain structure><Modeling><Modern Man><Molecular><Monitor><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuromodulator><Neurons><Neurophysiology / Electrophysiology><New York><Non-Polyadenylated RNA><Nucleus Accumbens><Optics><Phase><Photometry><Physiological Homeostasis><Population><Presynaptic Nerve Endings><Presynaptic Terminals><Probabilistic Models><Probability Models><Protein Biosynthesis><Proteins><Psychiatric Disease><Psychiatric Disorder><RNA><RNA Expression><RNA Gene Products><Rat><Rats Mammals><Rattus><Receptor Cell><Regulation><Research><Rewards><Ribonucleic Acid><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Role><Science><Serotonergic System><Serotonin><Sex Behavior><Sexual Activity><Sexual Behavior><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Site><Statistical Models><Synaptic Boutons><Synaptic Terminals><System><Techniques><Testing><Therapeutic Estrogen><Therapeutic Hormone><Time><Training><Transcription><Translations><Universities><Update><Ventral Tegmental Area><Water><Work><biological sensor><biological signal transduction><cognitive process><computational modeling><computational models><computer based models><computerized modeling><cost><design><designing><differential expression><differentially expressed><discount><discounting><dopamine transporter><dopaminergic neuron><electrophysiological><estrogenic><estrogenic activity><estrous><expectation><experience><experiment><experimental research><experimental study><experiments><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><insight><interdisciplinary approach><knock-down><knockdown><mRNA><male><mental illness><multidisciplinary approach><neural><neural circuit><neural circuitry><neural control><neural mechanism><neural regulation><neurocircuitry><neuromechanism><neuromodulation><neuromodulatory><neuronal><neurophysiological><neurophysiology><neuroregulation><novel><optical><optogenetics><preference><programs><protein synthesis><psychiatric illness><psychological disorder><reproductive><response><reuptake><serotonergic pathway><serotonin pathway><serotonin system><serotonin transporter><sex><sex activity><sexual activities><skills><social role><sodium-dependent serotonin transporter><statistical linear mixed models><statistical linear models><synaptic circuit><synaptic circuitry><tool><transcriptional differences><translation><translatome><ventral tegmentum><♀><♂>
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Adati Tarfa

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$158,545
FY 2026

Project Title

Community Pharmacy-Based Adaptation and Pilot Testing of Integrated HIV and Substance Use Disorder Care

Grant Number:

1K99DA064780-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/29/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Significant gaps in care exist in addressing the intersection of HIV and substance use disorder (SUD) treatment. Despite pharmacists providing evidence-based services for HIV prevention and harm reduction, their potential to reach those with co-occurring HIV and SUD has not ...

Research Terms

<AIDS Virus><AIDS care><AIDS prevention><AIDS test><AIDS/HIV test><Acceleration><Access to Care><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Affect><Alcohol Chemical Class><Alcohols><Application Context><Assess implementation><Awareness><Caring><Clinic><Clinical><Communities><Community Pharmacy><Complement><Complement Proteins><Comprehensive Health Care><Connecticut><Development><Diagnosis><Doctor of Pharmacy><Doctor of Philosophy><Drug usage><Drug user><Ensure><Epidemic><Evidence based intervention><Face><Focus Groups><Foundations><Funding><Future><Goals><HIV><HIV Care><HIV Prevention><HIV individuals><HIV infected individuals><HIV infected persons><HIV intervention><HIV medical care><HIV patient care><HIV people><HIV positive individuals><HIV positive people><HIV related care><HIV related patient care><HIV test><HIV therapeutic><HIV therapy><HIV treatment><HIV-1 care><HIV-1 intervention><HIV-1 prevention><HIV-1 test><HIV-1 therapeutic><HIV-1 therapy><HIV-1 treatment><HIV-2 test><HIV/AIDS prevention><Harm Minimization><Harm Reduction><Health Services><Health Services Accessibility><Hour><Human Immunodeficiency Virus therapy><Human Immunodeficiency Virus treatment><Human Immunodeficiency Viruses><Human immunodeficiency virus test><Hybrids><Implementation assessment><Improve Access><Individual><Intervention><Interview><Investigators><LAV-HTLV-III><Lived experience><Lived experiences><Lymphadenopathy-Associated Virus><Medicine><Mentorship><Methods><Modeling><Morbidity><NIDA><NIH><Naloxone><Narcan><Narcanti><National Institute of Drug Abuse><National Institute on Drug Abuse><National Institutes of Health><Needle-Exchange Programs><Opiates><Opioid><Outcome><PLWH><PRISM framework><PRISM model><PWH><PWUD><Patients><Perception><Persons><Ph.D.><PhD><Pharm.D.><PharmD><Pharmaceutic Services><Pharmaceutical Services><Pharmacies><Pharmacists><Pharmacy Services><Pharmacy facility><Phase><Position><Positioning Attribute><PrEP><Practical Robust Implementation and Sustainability Model><Pragmatic, Robust Implementation and Sustainability Model><Preparedness><Prevent HIV><Prevention><Public Health><RE-AIM><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Readiness><Reporting><Research><Research Personnel><Research Resources><Researchers><Resources><Service provision><Services><Shapes><Sterility><Stimulant><Substance Use Disorder><Survey Instrument><Survey Method><Survey Methodology><Surveys><Syringe-Exchange Programs><Syringes><System><Training><Transportation><United States National Institutes of Health><Virus-HIV><Walking><Work><access to health services><access to services><access to treatment><accessibility to health services><addiction><addictive disorder><availability of services><barrier to care><barrier to health care><barrier to treatment><barriers to implementation><care access><care of HIV-1><care services><care systems><community advisory board><community advisory committee><community advisory panel><community based participatory research><community engaged approach><community engaged approaches><community engaged strategies><community engaged strategy><community engagement><community led research><community participatory research><community partnered approach><community partnered participatory research><community partnered strategy><community setting><complementation><comprehensive care><contextual factors><design><designing><developmental><disease prevention><disorder prevention><distribute naloxone><drug use><effectiveness and implementation trial><effectiveness/implementation hybrid trial><effectiveness/implementation trial><engagement with communities><evaluate implementation><evaluation of implementation><evidence base><experience><faces><facial><facilitators to implementation><health service access><health services availability><health training><housing instability><human immunodeficiency virus care><implementation barriers><implementation challenges><implementation determinants><implementation evaluation><implementation facilitators><implementation factors><implementation outcomes><implementation science><implementation strategy><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><injection drug use><insight><instably housed><integrated care><integrated health care><integrated model of care><lack of stable housing><medical college><medical schools><naloxone availability><naloxone dispensary><naloxone dispensation><naloxone dispensing><naloxone distribution><naloxone provision><needle exchange><novel><obstacle to care><obstacle to health care><participatory action research><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people who use drugs><people who use illicit drugs><people with HIV><people with human immunodeficiency virus><persons who use drugs><pilot test><post implementation><pre-exposure prophylaxis><preference><prevent><prevent AIDS><prevent human immunodeficiency virus><preventing><programs><provide naloxone><reach, efficacy, adoption, implementation, and maintenance><school of medicine><screening><screenings><service availability><service delivery><service uptake><social stigma><sterile><stigma><strategies for implementation><substance use><substance use and disorder><substance using><syringe exchange><syringe exchange services><syringe service programs><syringe services><tool><treat HIV><treat Human Immunodeficiency Virus><treatment access><unstable housing><unstably housed>
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Sophie Arheix-Parras

UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA, COLUMBIA, SC

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$146,004
FY 2026

Project Title

Recovery from Post-Stroke Aphasia With rTMS Targeting The Anterior Temporal Lobe: Interhemispheric Activation Changes And Lesion-Connectome-Based Predictive Outcomes

Grant Number:

1K99DC023302-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/16/2026

End Date:

2/29/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

The K99/R00 Award will support my transition to an independent researcher focused on using repetitive Transcranial Magnetic Stimulation (rTMS) to enhance post-stroke aphasia recovery. The majority of non-invasive brain stimulation (NIBS) studies, including those using rTMS, apply facilitatory stimul...

Research Terms

<Address><Affect><Alogia><Amnesic Aphasia><Anepia><Anomia><Anomic Aphasia><Anomic Dysphasia><Anterior><Aphasia><Apoplexy><Area><Award><Brain><Brain Nervous System><Brain Vascular Accident><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Clinical><Clinical Trials><Communication><Complex><Data><Doctor of Philosophy><Dysnomia><Encephalon><Ensure><Equilibrium><Functional MRI><Functional Magnetic Resonance Imaging><Future><GeneHomolog><Homolog><Homologous Gene><Homologue><Impairment><Individual><Individual Differences><Inferior Frontal Convolution><Inferior frontal gyrus><Investigation><Investigators><Language><Language Therapy><Left><Lesion><Linguistic><Linguistics><Link><Localized Lesion><Logagnosia><Logamnesia><Logasthenia><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Maps><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mentorship><Methodology><Modeling><NMR Imaging><NMR Tomography><Names><Nominal Aphasia><Nominal Dysphasia><Nuclear Magnetic Resonance Imaging><Outcome><Participant><Patient Self-Report><Pattern><Persons><Ph.D.><PhD><Phase><Play><Population><Process><Production><QOL><Quality of life><Randomized, Controlled Trials><Recovery><Research><Research Personnel><Researchers><Rest><Role><Scientist><Self-Report><Semantics><Specialist><Speech><Speech Therapy><Stroke><Symptoms><System><Techniques><Temporal Lobe><Therapeutic Intervention><Training><Treatment Efficacy><Work><Zeugmatography><after stroke><aphasia due to stroke><aphasia following stroke><aphasia recovery><arm><balance><balance function><brain attack><cerebral vascular accident><cerebrovascular accident><connectome><experience><fMRI><improved><improved outcome><individual response><individualized response><insight><intervention efficacy><intervention therapy><language impairment><language processing><name><named><naming><neural><non-invasive brain stimulation><novel><outcome prediction><post stroke><poststroke><poststroke aphasia><predict responsiveness><predicting response><randomized control trial><randomized, clinical trials><recovery in aphasia><recovery in patients with aphasia><recovery in people with aphasia><recovery of people with aphasia><repetitive transcranial magnetic stimulation><response><semantic processing><skills><social role><stroke aphasia><stroke survivor with aphasia><stroke-induced aphasia><stroked><strokes><success><temporal cortex><theories><therapeutic efficacy><therapy efficacy>
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Hanieh Mazloom Farsibaf

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$140,097
FY 2026

Project Title

Data-driven mechanistic models of morphology-controlled Ras oncogenic signaling

Grant Number:

5K99CA283246-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project summary – Data-driven mechanistic models of morphology-controlled Ras oncogenic signaling. Cells adapt their shape during differentiation and transformation processes, or when exposed to environmental changes or drug challenges. Accordingly, cell geometry is often considered as a marker for ...

Research Terms

<1-Phosphatidylinositol 3-Kinase><3-D><3-D Images><3-D image><3-Dimensional><3D><3D image><3D images><Actins><Address><Affect><Anoikis><Behavior><Biological><Biophysics><Bleb><Blister><Blood Plasma Cell><Body Tissues><Brachydanio rerio><Bulla><Bullous Lesion><Calibration><Cancer Biology><Cancer Prognosis><Cancers><Cell Body><Cell Communication and Signaling><Cell Function><Cell Growth in Number><Cell Multiplication><Cell Physiology><Cell Process><Cell Proliferation><Cell Signaling><Cell Survival><Cell Viability><Cell membrane><Cells><Cellular Function><Cellular Morphology><Cellular Physiology><Cellular Process><Cellular Proliferation><Cellular biology><Computer Models><Computerized Models><Coupling><Cues><Cytoplasmic Membrane><Danio rerio><Data><Data Analyses><Data Analysis><Diffusion><Drugs><Environment><Event><Ewing's Family of Tumours><Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor><Ewing's Tumor><Ewings sarcoma><Exhibits><Exposure to><Feedback><Formulation><Frequencies><Geometry><Goals><Hyperactivity><Intracellular Communication and Signaling><Intuition><MAP kinase><Macrophage><Malignant Cell><Malignant Melanoma><Malignant Neoplasms><Malignant Tumor><Math><Mathematics><Measures><Medication><Melanoma><Melanoma Cell><Membrane><Merlin><Mitogen-Activated Protein Kinases><Modeling><Moesin-Ezrin-Radixin-Like Protein><Molecular><Morphology><Mutate><Mφ><NF2><NF2 Gene Product><NF2 gene><Natural regeneration><Neck><Neurofibromatosis 2 Gene Product><Neurofibromatosis 2 Genes><Neurofibromatosis Type 2 Protein><Neurofibromin 2><Oncogenesis><Oncogenic><Outcome><PI-3 Kinase><PI3-Kinase><PI3CG><PI3KGamma><PI3k><PIK3><PIK3CG><PIK3CG gene><Paper><Pathology><Pharmaceutical Preparations><Phase><Phenotype><Phosphatidylinositol 3-Kinase><Phosphatidylinositol-3-OH Kinase><Phosphoinositide 3-Hydroxykinase><Plasma Cells><Plasma Membrane><Plasmacytes><Process><Proliferating><PtdIns 3-Kinase><Reaction><Regeneration><Research><Resistance><Schwannomerlin><Schwannomin><Schwannomin Protein><Shapes><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><Supervision><Surface><System><Systems Biology><T lymphoma invasion and metastasis><T-Lymphoma Invasion and Metastatis Inducing Protein 1><TIAM1><TIAM1 Protein><TIAM1 gene><Testing><Three-Dimensional Image><Tissues><Training><Translating><Tumor Suppressor Proteins><Type I Phosphatidylinositol Kinase><Type III Phosphoinositide 3-Kinase><Vesication><Work><Zebra Danio><Zebra Fish><Zebrafish><acquired drug resistance><biologic><biological signal transduction><biological systems><biophysical foundation><biophysical principles><biophysical sciences><cancer biomarkers><cancer cell><cancer diagnosis><cancer markers><career><cell behavior><cell biology><cell morphology><cell transformation><cellular behavior><computational framework><computational modeling><computational models><computational pipelines><computational platform><computer based models><computer framework><computerized modeling><computing platform><data interpretation><diffused><diffuses><diffusing><diffusions><drug/agent><environmental change><image guidance><image guided><intuitive><live cell image><live cell imaging><live cellular image><live cellular imaging><malignancy><membrane structure><mutant><neoplasm/cancer><nf 2 Genes><novel><plasmalemma><plasmocyte><programs><regenerate><resistant><response><scaffold><scaffolding><side effect><spatial and temporal><spatial temporal><spatiotemporal><three dimensional><tool><transformed cells><tumor><tumor suppressor><tumorigenesis>
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Jelly Hubertus Maria Soffers

UNIVERSITY OF MISSOURI KANSAS CITY, KANSAS CITY, MO

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$137,687
FY 2026

Project Title

Gene-regulatory mechanisms of neuronal circuit formation in Drosophila

Grant Number:

1K99NS146609-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/9/2026

End Date:

2/28/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Brain function depends on the precise assembly of neural circuits during development, but the gene-regulatory principles that govern how neuronal lineages integrate into functional circuits remain poorly understood. Using the Drosophila Ventral Nerve Cord (VNC) as a model, t...

Research Terms

<3-D><3-Dimensional><3D><Address><Anatomic Sites><Anatomic structures><Anatomy><Behavior><Birth Order><Brain><Brain Nervous System><CNS Nervous System><Cell Body><Cells><Central Nervous System><Cities><Collaborations><Complex><Connector Neuron><Data><Data Set><Dedications><Development><Development Plans><Drosophila><Drosophila genus><EASI><Encephalon><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epithelial Cell Aggregation and Separation><Equilibrium><Experimental Models><Flies><Foundations><Gene Expression><Genes><Genetic><Goals><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Kansas><Knowledge><Link><Maps><Medulla Spinalis><Mentors><Mentorship><Microscopy><Missouri><Modeling><Molecular><Morphology><Motor><Motor Cell><Motor Neurons><Muscle><Muscle Tissue><Nerve><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Transmitter Substances><Nerve Unit><Neural Cell><Neural Stem Cell><Neuraxis><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuronal Transmission><Neurons><Neurotransmitters><Pathology><Pathway interactions><Pattern><Polycomb><Preparation><Process><Proteins><Research><Resolution><Role><Scientist><Specific qualifier value><Specified><Spinal Cord><Synapses><Synaptic><System><Technical Expertise><Techniques><Universities><Work><analog><axon signaling><axon-glial signaling><axonal signaling><balance><balance function><career><career development><cell behavior><cell type><cellular behavior><connectome><developmental><developmental neurobiology><epigenetically><fly><fruit fly><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><glia signaling><glial signaling><global gene expression><global transcription profile><insight><motoneuron><muscular><nerve signaling><nerve stem cell><neural><neural circuit><neural circuitry><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural signaling><neural stem and progenitor cells><neuroblast><neurocircuitry><neurodevelopmental disease><neurogenic progenitors><neurogenic stem cell><neuron development><neuron progenitors><neuronal><neuronal circuit><neuronal circuitry><neuronal development><neuronal progenitor><neuronal progenitor cells><neuronal signaling><neuronal stem cells><neuroprogenitor><neurotransmission><novel><pathway><preparations><progenitor and neural stem cells><programs><resolutions><response><scRNA sequencing><scRNA-seq><sibling order><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><support network><synapse><synaptic circuit><synaptic circuitry><technical skills><three dimensional><tool><transcriptome><treatment strategy>
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Hanah M Georges

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$132,823
FY 2026

Project Title

Role of TLR7/8-activating microRNAs in fetal inflammatory response syndrome

Grant Number:

5K99HD116981-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Preterm birth is commonly associated with chorioamnionitis; infection/inflammation of the fetal membranes (FM). Pathogens contributing to this do not typically cross the placenta. However, abnormal maternal and/or placental immune responses can cause inflammation in the fetus, contributing to Fetal ...

Research Terms

<3-10C><AMCF-I><Advisory Committees><Affect><Amnionitides><Amniotic Fluid><Aqua Amnii><Automobile Driving><Biogenesis><Biology><Blood Precursor Cell><Body Tissues><Bone Development><Brain><Brain Nervous System><CXCL8><Cell Communication and Signaling><Cell Line><Cell Signaling><CellLine><Cells Placenta-Tissue><Chorioamnionitis><Communication Methods><Cord Blood><Data><Developing fetus><Development><Diagnostic><Dose><Double-Stranded RNA><Embryo Transfer><Encephalon><Exposure to><Faculty><Family><Fetal Development><Fetal Membranes><Fetal Tissues><Fetus><Fluorescence Light Microscopy><Fluorescence Microscopy><Future><GCP1><Genotype><Health><Hematopoietic><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Histology><Homolog of Drosophila TOLL><Human><IL-8><IL8><IL8 gene><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune response><Immune system><Immunes><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><In Vitro><Infection><Infection of amniotic cavity><Infection of amniotic sac and membranes><Inflammation><Inflammatory><Inflammatory Response><Injury><Institution><Intracellular Communication and Signaling><Investigators><K60><Label><Liquor Amnii><Liver><Lung><Lung Respiratory System><Maternal Exposure><Measures><Mediating><Mentors><Mentorship><Mice><Mice Mammals><MicroRNAs><Modern Man><Mothers><Murine><Mus><Neonatal><Neonatal Mortality><Normal Placentoma><Origin of Life><Osteoclasts><Pathology><Phase><Placenta><Placenta Embryonic Tissue><Placentome><Poly I-C><Polyinosinic-Polycytidylic Acid><Position><Positioning Attribute><Premature Birth><Prematurely delivering><Preterm Birth><Prevention><Process><RNA Seq><RNA sequencing><RNAseq><Reproduction Immunology><Reproductive Immunology><Research Personnel><Research Resources><Researchers><Resources><Role><SCYB8><Secure><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Stem Cell Development><Sterility><Stimulus><Strains Cell Lines><TLR protein><TLR4><TLR4 gene><TLR7><TLR7 gene><TLR8><TLR8 gene><TSG-1><Tail><Task Forces><Testing><Tissues><Toll Homologue><Toll-Like Receptor 7><Toll-Like Receptor 8><Toll-Like Receptor Family Gene><Toll-like receptors><Training><Umbilical Cord Blood><Universities><Viral><Wild Type Mouse><Work><abnormal brain function><advisory team><b-ENAP><biological signal transduction><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><bone><brain dysfunction><brain impairment><cultured cell line><death among neonates><death among newborns><death in neonates><death in newborn><developmental><driving><dsRNA><dysfunctional brain><embryo transplantation><exosome><experience><fetal><fetal cell><fetal cord blood><fetal inflammatory response syndrome><fetal medicine><fetus cell><fetus membrane><fetus tissue><fluorescence imaging><fluorescent imaging><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><hepatic body system><hepatic organ system><host response><immune system response><immunoresponse><in vivo><in vivo Model><inflammation marker><inflammatory marker><inhibitor><injuries><insight><intra-amniotic infection><intraamniotic infection><miRNA><mortality among neonates><mortality among newborns><mortality in neonates><mortality in newborns><neonatal brain><neonatal death><neonatal demise><neonatal morbidity><newborn death><newborn morbidity><newborn mortality><novel><organ development><organ growth><pathogen><poly I:C><poly IC><poly(I:C)><postnatal><pregnant><premature childbirth><premature delivery><prenatal><preterm delivery><progenitor cell development><progenitor development><response><sensor><skill acquisition><skill development><social role><stem and progenitor cell development><sterile><toll-like receptor 4><trafficking><transcriptome sequencing><transcriptomic sequencing><unborn><wildtype mouse>
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Antonio Francisco Pagán

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, HOUSTON, TX

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$132,027
FY 2026

Project Title

Psychosocial and Neural Mechanisms for a Culturally and Linguistically Adapted Treatment for Bilingual Latino Young Adults with Autism

Grant Number:

5K99HD118079-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Candidate: This K99/R00 Pathway to Independence Award proposal aims to provide me with the training needed (K99 phase) to execute mental health clinical trials (R00 phase) for Latinos with autism spectrum disorder (ASD) during their transition to adulthood.1 My preliminary community-based participat...

Research Terms

<21+ years old><ASD><Acceleration><Active Follow-up><Address><Adolescent><Adolescent Youth><Adult><Adult Human><After Care><After-Treatment><Aftercare><Anterior><Anxiety><Area><Autism><Autistic Disorder><Autistic young adult><Award><Behavior><Biological Markers><Brain><Brain Nervous System><Central Lobe><Childhood><Clinical Sciences><Clinical Treatment><Clinical Trials><Communities><Community Health Aides><Data><Development><Early Infantile Autism><Early-Stage Clinical Trials><Emotions><Encephalon><Ensure><Espanol><Evidence based treatment><Face><Fellowship><Focus Groups><Functional MRI><Functional Magnetic Resonance Imaging><Funding><Future><General Population><General Public><Goals><Group Meetings><Image><Infantile Autism><Inferior Frontal Convolution><Inferior frontal gyrus><Insula><Insula of Reil><Intervention><Intervention Trial><Interventional trial><Interview><Investigators><Island of Reil><Kanner's Syndrome><Knowledge><Language><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><Learning><Linguistic><Linguistics><Mediating><Mental Depression><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Mentors><Methodology><Modeling><NICHD><NIH><National Institute of Child Health and Human Development><National Institutes of Health><Outcomes Research><Parents><Parietal><Participant><Pathway interactions><Pattern><Phase><Phase 1 Clinical Trials><Phase I Clinical Trials><Prevalence><Procedures><Protocol><Protocols documentation><Psychiatric Disease><Psychiatric Disorder><Psychological Health><QOL><Quality of life><Randomized><Randomized, Controlled Trials><Research><Research Personnel><Researchers><Sampling><Scientist><Self Management><Shapes><Socialization><Spanish><Stimulus><Structure><Structure of superior temporal sulcus><Suggestion><Superior Temporal Sulcus><Symptoms><Techniques><Technology><Telemedicine><Testing><Training><Translating><Translational Research><Translational Science><Treatment Efficacy><Treatment outcome><Underserved Population><United States><United States National Institutes of Health><Validation><Work><active followup><adult with ASD><adult with autism><adult with autism spectrum disorder><adult youth><adulthood><adulthood transition><adults on the autism spectrum><adults on the spectrum><autism spectral disorder><autism spectrum disorder><autistic adult><autistic children><autistic spectrum disorder><bilingual><bilingualism><bio-markers><biologic marker><biomarker><career><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical center><clinical intervention><clinical therapy><community advisory board><community advisory committee><community advisory panel><community based participatory research><community health worker><community led research><community participatory research><community partnered participatory research><community partners><community-based partners><cultural values><depression><design><designing><developmental><evidence base><executive control><executive function><experience><fMRI><faces><facial><follow up><follow-up><followed up><followup><imaging><implementation science><improved><individualized therapeutic><innovate><innovation><innovative><insight><interest><intervention efficacy><juvenile><juvenile human><mental illness><multi-modality><multimodality><neural><neural imaging><neural mechanism><neuro-imaging><neuroimaging><neurological imaging><neuromechanism><novel><parent><participant interview><participatory action research><pathway><pediatric><personalized therapeutic><phase I protocol><physical conditioning><physical health><post treatment><programs><psychiatric illness><psychological disorder><psychosocial><randomisation><randomization><randomized control trial><randomized, clinical trials><randomly assigned><recruit><response to therapy><response to treatment><satisfaction><skills><social cognition><social communication><therapeutic efficacy><therapeutic response><therapy efficacy><therapy response><transition from adolescence to adulthood><transition into adulthood><transition to adulthood><translation research><translational investigation><treatment response><treatment responsiveness><trial design><trial regimen><trial treatment><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people><validations><young adult><young adult age><young adult with ASD><young adult with autism><young adult with autism spectrum disorder><young adulthood>
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Shuo Li

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$130,345
FY 2026

Project Title

Comprehensive monitoring of diverse cancer outcomes using genomic and epigenomic sequencing of cfDNA

Grant Number:

5K99CA290092-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Cancer monitoring is essential for the early detection and timely intervention of various adverse outcomes, such as minimal residual disease (MRD), recurrence, and side effects. Plasma cell-free DNA (cfDNA) has shown great promise for cancer monitoring due to its unique advantages: (...

Research Terms

<Address><Adverse Experience><Adverse event><Atlases><Award><Biologic Characteristic><Biological><Biological Characteristics><Blood Plasma Cell><Body Tissues><Cancer Patient><Cancer Treatment><Cancers><Cell Communication and Signaling><Cell Signaling><Cell Survival><Cell Viability><Characteristics><Clinical><Collaborations><Collection><Communities><Competence><Computational Biology><Computing Methodologies><DNA><DNA Methylation><DNA analysis><DNA methylation profiling><DNA mutation><Data><Data Analyses><Data Analysis><Deoxyribonucleic Acid><Detectable Residual Disease><Detection><Detection of Minimal Residual Disease><Development><Dysfunction><Early Diagnosis><Early Intervention><Ensure><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Equipment><Faculty><Foundations><Functional disorder><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genomics><Goals><Intervention><Intracellular Communication and Signaling><Investigators><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mentors><Mentorship><Methods><Methyl-Seq><MethylSeq><Methylation><Methylation sequencing><Minimal Residual Disease><Modeling><Molecular><Molecular Fingerprinting><Molecular Profiling><Monitor><Monitoring for Recurrence><Mutation><Noise><Organ><Outcome><PET/CT><PET/CT scan><Patients><Performance><Persons><Phase><Physiopathology><Plasma Cells><Plasmacytes><Population><Position><Positioning Attribute><Privatization><QOL improvement><Qualifying><Recurrence><Recurrent><Research><Research Methodology><Research Methods><Research Personnel><Researchers><Residual Neoplasm><Residual Tumors><Resolution><Sampling><Selection for Treatments><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Statistical Methods><System><Time><Tissues><Training><Treatment outcome><Wing><Work><adverse consequence><adverse outcome><analyze DNA><anti-cancer research><anti-cancer therapy><biologic><biological signal transduction><cancer care><cancer research><cancer therapy><cancer-directed therapy><cell free DNA><cell free DNA profiling><cell free DNA screening><cell free DNA-based assay><cell free circulating DNA><cell-free DNA assay><cell-free DNA test><cfDNA assay><cfDNA profiling><cfDNA screening><cfDNA test><cfDNA-based assay><clinical practice><computational methodology><computational methods><computer based method><computer based prediction><computer biology><computer methods><computing method><continuous monitoring><cost><data interpretation><deep learning><deep learning method><deep learning strategy><detection method><detection procedure><detection sensitivity><detection technique><developmental><early detection><epigenetically><epigenomics><exome><genome mutation><human tissue><improved><improvements in QOL><improvements in quality of life><individualized cancer care><individualized oncology><innovate><innovation><innovative><liquid biopsy><malignancy><method development><methylome><molecular profile><molecular signature><multiomics><multiple omics><mutant><neoplasm/cancer><panomics><pathophysiology><patient population><personalized oncology><plasmocyte><positron emission computed tomography><precision cancer care><precision cancer medicine><precision medicine><precision oncology><precision-based medicine><predictive modeling><prognosis model><prognostic model><quality of life improvement><research and methods><residual disease><resolutions><selection of treatment><side effect><skill acquisition><skill development><statistic methods><statistics><tenure process><tenure track><test using cell free DNA><tests using cfDNA><therapy selection><treatment selection><trend><tumor>
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Giulia Carli

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$128,358
FY 2026

Project Title

Exploring Cholinergic Changes and their Associations with Sleep Alterations in the Lewy Body Disease Spectrum: New Biomarkers and Therapeutic Targets

Grant Number:

1K99NS146570-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/16/2026

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Abstract Cholinergic brain activity plays a crucial role in regulating sleep, particularly Rapid Eye Movement (REM) sleep, as demonstrated in animal studies. How these findings translate to humans remains insufficiently explored. Understanding the neurobiology of sleep in humans is critical, as slee...

Research Terms

<Acetylcholine><Active Follow-up><Affect><Animal Model><Animal Models and Related Studies><Animals><Area><Binding><Biological Markers><Brain><Brain Nervous System><Brain Stem><Brain imaging><Brainstem><Chemicals><Clinical><Data><Degenerative Neurologic Disorders><Dementia with Lewy Bodies><Devices><Diagnosis><Disease><Disorder><Down-Regulation><Drowsiness><Dysfunction><Encephalon><Excessive Daytime Sleepiness><Excessive daytime somnolence><Fast-Wave Sleep><Friends><Functional disorder><Generations><Goals><Home><Human><Imaging Procedures><Imaging Technics><Imaging Techniques><Individual><Investigation><LB disease><LB disorder><Lewy Body Disease><Lewy body disorder><Lewy disease><Lewy disorder><Link><Measures><Methods><Modeling><Modern Man><Molecular><Molecular Interaction><Monitor><NREM><Nerve Degeneration><Nerve Impulse Transmission><Nerve Transmission><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurobiology><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neuronal Transmission><PET><PET Scan><PET imaging><PETSCAN><PETT><Paradoxical Sleep><Paralysis Agitans><Parietal Lobe><Parkinson><Parkinson Disease><Patient Self-Report><Patients><Performance><Phase><Physiopathology><Play><Polysomnography><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Primary Parkinsonism><Questionnaires><REM Behavior Disorder><REM Sleep><REM Sleep Behavior Disorder><Rad.-PET><Rapid Eye Movement Behavior Disorder><Rapid Eye Movement Sleep Behavior Disorder><Reporting><Research><Rhombencephalic Sleep><Role><Self-Report><Sleep><Sleep Architecture><Sleep Monitoring><Sleep Wake Cycle><Sleep disturbances><Somnography><Somnolence><Structure><Symptoms><Synaptic Vesicles><System><Technology><Testing><Training><Translating><Upregulation><VAChT protein><Validation><aberrant sleep><acetylcholine transporter><active followup><axon signaling><axon-glial signaling><axonal signaling><bio-markers><biologic marker><biomarker><brain health><brain visualization><cholinergic><clinical diagnosis><cohort><computer based prediction><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><disease diagnosis><disrupted sleep><disturbed sleep><dreaming sleep><follow up><follow-up><followed up><followup><frontal cortex><frontal lobe><glia signaling><glial signaling><home based monitoring><home monitoring><homes><human model><impaired sleep><improvement on sleep><in vivo><insight><interest><irregular sleep><model of animal><model of human><nerve signaling><neural degeneration><neural imaging><neural signaling><neuro-imaging><neurobiological><neurodegeneration><neurodegenerative><neurodegenerative illness><neuroimaging><neurological degeneration><neurological imaging><neuronal degeneration><neuronal signaling><neuroprotection><neuroprotective><neurotransmission><non rapid eye movement><non-REM><non-rapid eye movement><nonREM><nonrapid eye movement><novel><parietal cortex><pathophysiology><patient population><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><predictive modeling><programs><radiolabel><radiolabels><radiotracer><rapid eye movement><rapid eye movement sleep><recruit><skill acquisition><skill development><sleep amount><sleep control><sleep disruption><sleep duration><sleep dysregulation><sleep episode><sleep improvement><sleep interval><sleep length><sleep measurement><sleep pattern><sleep period><sleep polysomnography><sleep quantity><sleep regulation><sleep routine><sleep schedule><sleep time><sleep to wake transition><sleep to wakefulness transition><sleep wakefulness cycle><sleep/wake disruption><sleep/wake disturbance><sleep/wake patterns><sleep/wake regulation><sleep/wake transitions><sleepiness><social role><therapeutic target><time asleep><time during sleep><time in sleep><time spent asleep><time spent sleeping><tool><translation to humans><translational goal><translational mission><validations><vesicle release><vesicular acetylcholine transporter><vesicular release><wearable><wearable device><wearable electronics><wearable system><wearable technology><wearable tool><wearables>
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Jonathan webster markert

HARVARD MEDICAL SCHOOL, BOSTON, MA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$125,000
FY 2026

Project Title

The Molecular Basis of Transcription-Replication Conflicts and Pathways to Resolution

Grant Number:

1K99GM163010-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/29/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract: Transcription and replication machineries frequently collide, leading to transcription-replication conflicts that destabilize the genome if not resolved, which contributes to diseases such as cancer. Despite their destructive potential, the mechanisms behind these conflict...

Research Terms

<Assay><Automobile Driving><Binding><Bioassay><Biochemical><Biochemistry><Biological><Biological Assay><Biological Chemistry><Cancers><Cell Body><Cells><Communities><Complex><Conflict><Conflict (Psychology)><Critical Paths><Critical Pathways><Cryo-electron Microscopy><Cryoelectron Microscopy><DNA><DNA Helicases><DNA Polymerases><DNA Replication><DNA Synthesis><DNA Unwinding Proteins><DNA biosynthesis><DNA mutation><DNA unwinding enzyme><DNA-Dependent DNA Polymerases><DNA-Dependent RNA Polymerase II><DNA-Directed DNA Polymerase><Deoxyribonucleic Acid><Deposit><Deposition><Disease><Disorder><Electron Cryomicroscopy><Engineering><Ensure><Environment><Foundations><Gene Transcription><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Genome Instability><Genome Stability><Genomic Instability><Genomic Stability><Genomics><Head><Health><Human><Hybrids><In Vitro><Investigators><Knowledge><Lead><Link><Malignant Neoplasms><Malignant Tumor><Mediating><Mentorship><Mission><Modern Man><Molecular><Molecular Interaction><Mutation><NELF><NIH><National Institutes of Health><Nature><Non-Polyadenylated RNA><Nucleosomes><P-TEFb><Pathway interactions><Pb element><Phase><Position><Positioning Attribute><Positive Transcription Elongation Factor B><Positive Transcriptional Elongation Factor B><Postdoc><Postdoctoral Fellow><Process><Protein Conformation><RNA><RNA Expression><RNA Gene Products><RNA Polymerase B><RNA Polymerase II><Reaction><Research><Research Associate><Research Personnel><Researchers><Resolution><Ribonucleic Acid><Role><SII transcription elongation factor><Source><System><TFIIS><TFIIS elongation factor><Technology><Training><Transcription><United States National Institutes of Health><Visualization><Work><biologic><candidate validation><conflict resolution><cryo-EM><cryoEM><cryogenic electron microscopy><driving><elongation factor SII><epigenetic memory><genome integrity><genome mutation><genomic integrity><heavy metal Pb><heavy metal lead><helicase><histone modification><human disease><improved><insight><malignancy><nanopore based sequencing><nanopore long read seq><nanopore long-read sequencing><nanopore seq><nanopore sequencing><nanopore-based long-read sequencing><negative elongation factor><neoplasm/cancer><novel><pathway><post-doc><post-doctoral><post-doctoral trainee><premature><prematurity><prevent><preventing><reconstitute><reconstitution><recruit><research associates><resolutions><response><skills><social role><strand transfer protein alpha><structural biology><tat-Associated Kinase><therapeutic target><transcription elongation factor A><transcription elongation factor S-II><transcription factor IIS><transcription factor S-II>
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Daniel J Fehrenbach

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$123,930
FY 2026

Project Title

Novel role of ROCK2 in Immune Mechanisms of Takotsubo Cardiomyopathy

Grant Number:

5K99HL177309-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/20/2024

End Date:

11/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Takotsubo Cardiomyopathy (TCM) is an acute, life-threatening condition triggered by an intense physical or emotional stressor and characterized by cardiac dysfunction, apical ballooning of the left ventricle, and thinning of the ventricular wall. With maximal medical care, patients may recover, but ...

Research Terms

<ATP-protein phosphotransferase><Acute><Adoptive Transfer><AngII><Angiotensin II><Apical><Assay><Attenuated><Automobile Driving><Bioassay><Bioavailability><Biological Assay><Biological Availability><Blood Pressure><Blood monocyte><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Cardiac><Cardiomyopathies><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Caring><Catecholamines><Cell Culture Techniques><Cessation of life><Chronic><Clinic><Data><Death><Development><Development Plans><Diagnosis><Dose><Drops><Dysfunction><EFRAC><Ejection Fraction><Emotional><Environment><Enzyme Gene><Enzymes><Event><Exhibits><FDA approved><Fibrosis in the heart><Fibrosis in the myocardium><Fibrosis within the heart><Fibrosis within the myocardium><Fibrotic myocardium><Foundations><Functional disorder><Future><General Population><General Public><Genetic Technics><Genetic Techniques><Guidelines><Heart><Heart Vascular><Heart failure><History><Human><Hypertension><Immune><Immune Cell Activation><Immune response><Immunes><Immunity><In Vitro><Infiltration><Inflammation><Inflammatory><Infusion><Infusion procedures><Investigators><Isoprenaline><Isopropyl Noradrenaline><Isopropylarterenol><Isopropylnoradrenaline><Isopropylnorepinephrine><Isoproterenol><Isuprel><Kinase Family Gene><Kinases><Knock-out><Knockout><Laboratories><Lead><Leanness><Learning><Left Ventricles><Left ventricular structure><Life><Life Expectancy><Long-Term Care><Long-Term Potentiation><Macrophage><Macrophage Activation><Marrow monocyte><Medical><Mentors><Methods><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Myelogenous><Myeloid><Myeloid Cells><Myocardial Diseases><Myocardial Disorder><Myocardial depression><Myocardial dysfunction><Myocardiopathies><Mφ><Oral><Overdose><Pathology><Pathway interactions><Patient Care><Patient Care Delivery><Patients><Pb element><Persons><Phagocytes><Phagocytic Cell><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Phase><Phenotype><Phosphotransferase Gene><Phosphotransferases><Physiologic><Physiologic Availability><Physiological><Physiopathology><Play><Pre-Clinical Model><Preclinical Models><Prevalence><Production><Protein Kinase><RNA Seq><RNA sequencing><RNAseq><Recommendation><Recording of previous events><Recovery><Research><Research Personnel><Researchers><Risk><Rodent Model><Role><Stress><Stress cardiomyopathy><Sympathins><Symptoms><Syndrome><Takotsubo><Testing><Thinness><Tissues><Training><Translating><Transphosphorylases><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Ventricular><Work><acute coronary syndrome><amebocyte><attenuate><attenuates><biological adaptation to stress><cardiac dysfunction><cardiac failure><cardiac fibrosis><cardiac function><cardiovascular disorder><cardiovascular risk><cardiovascular risk factor><care for patients><care of patients><career><career development><caring for patients><cell culture><cell cultures><circulatory system><coronary fibrosis><cytokine><death risk><developmental><driving><experience><extended care><fibrotic heart><function of the heart><glycogen synthase a kinase><heart dysfunction><heart fibrosis><heart function><heavy metal Pb><heavy metal lead><high blood pressure><histories><host response><hydroxyalkyl protein kinase><hyperpiesia><hyperpiesis><hypertensive><hypertensive disease><hypertensive disorder><hypoimmunity><immune activation><immune deficiency><immune system response><immunodeficiency><immunoresponse><in vivo><infusions><inhibitor><malleable risk><modifiable risk><monocyte><mortality risk><myocardial fibrosis><myocardium disease><myocardium disorder><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><pathophysiology><pathway><pharmaceutical><phosphorylase b kinase kinase><pre-clinical><preclinical><prevent><preventing><progenitor><programs><reactioncrisis><recruit><response><rho><social role><stress response><stress-induced cardiomyopathy><stressreaction><stressor><therapeutic target><transcriptome sequencing><transcriptomic sequencing><transcriptomics>
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Mara Getz Sheftel

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$121,239
FY 2026

Project Title

Loneliness and inflammatory markers as biopsychosocial pathways to AD/ADRD: Analysis of a rapidly aging segment of the US population

Grant Number:

1K99AG097922-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/5/2026

End Date:

2/29/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT Career Goal: My career goal is to become a leading independent investigator contributing rigorous social science research to understand cognitive health differences among the growing population of older immigrants in the US. With the immigrant population 65 and older expected to double to 2...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><ADRD><Address><Age><Aged 65 and Over><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Area><Attention><Biological><Biological Markers><Blood Plasma><Buffers><Characteristics><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Country><Data><Demographer><Development><Disturbance in cognition><Dysfunction><Ensure><Epidemiology><Functional disorder><Future><General Population><General Public><Goals><Health><Health and Retirement Study><Heterogeneity><Immigrant><Impaired cognition><Inflammation><Inflammatory><Intervention><Investigators><Knowledge><Latino Population><Latino group><Latino individual><Latino people><Latinos><Life Cycle><Life Cycle Stages><Link><Loneliness><Mediating><Mediation><Mediator><Mentorship><Methodology><Methods><Mexican><Migrant><Negotiating><Negotiation><Non-migrant><Nonmigrant><Older Population><Pathway interactions><Physiopathology><Plasma><Plasma Serum><Population><Prevalence><Primary Senile Degenerative Dementia><Principal Investigator><Process><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Reticuloendothelial System, Serum, Plasma><Risk><Risk Factors><Scholarship><Scientist><Shapes><Social Network><Social support><Sociology><Stress><Survey Instrument><Surveys><Time><Training><United States><above age 65><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><ages><alzheimer risk><bio-markers><biologic><biologic marker><biomarker><biopsychosocial><career><career development><cognitive assessment><cognitive dysfunction><cognitive function><cognitive loss><cognitive testing><cohort><dementia risk><developmental><differences in health><emotional distress><epidemiologic><epidemiological><experience><family support><feeling distress><feeling upset><geriatric mental health><health difference><high risk><human old age (65+)><inflammation marker><inflammatory marker><innovate><innovation><innovative><late in life><late life><life course><lonely><malleable risk><mid life><mid-life><middle age><middle aged><midlife><migration><modifiable risk><multidisciplinary><novel><older adult><older adulthood><older groups><older individuals><older person><over 65 years><pathophysiology><pathway><physical conditioning><physical health><physical separation><prevent><preventing><primary degenerative dementia><programs><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><senile dementia of the Alzheimer type><skills><social><social determinants><social relationships><social science research><social support network><sociodeterminant><systemic inflammation><systemic inflammatory response><trend><≥65 years>
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Yu Chen

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$119,785
FY 2026

Project Title

Mapping cerebellar influence in FTD: unraveling the role of the cerebellum in social cognition and clinical trajectory

Grant Number:

1K99AG097973-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/29/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Behavioral variant frontotemporal dementia (bvFTD) is a devastating neurodegenerative disorder characterized by early and profound social cognitive deficits, including impairments in theory of mind, emotion reading, and empathy, which cause significant distress and burden fo...

Research Terms

<Accounting><Address><Aging><Amentia><Architecture><Atrophic><Atrophy><Award><Biological Markers><Brain><Brain Nervous System><Burden on their caregivers><California><Caregiver Burden><Cerebellar degeneration><Cerebellum><Cerebrum><Clinical><Clinical Data><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive Manifestations><Cognitive Symptoms><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Complex><Data><Data Set><Degenerative Neurologic Disorders><Dementia><Diagnosis><Diagnostic><Disease><Disease Progression><Disease stratification><Disorder><Distress><Disturbance in cognition><Early Diagnosis><Early identification><Emotions><Empathy><Encephalon><Engineering / Architecture><Environment><FTLD><Foundations><Frontal Temporal Lobar Degeneration><Frontotemporal Lobar Degenerations><Frontotemporal variety lobar degeneration><Functional impairment><Future><Goals><Image><Impaired cognition><Impairment><Individual><Inferior><Institution><Intervention><Intervention Strategies><Investigation><Investigators><Lead><Life><Link><Maps><Measures><Memory><Mentorship><Modeling><Monitor><Motor><NIH><National Institutes of Health><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Neuropsychologies><Neuropsychology><Outcome><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pb element><Phase><Position><Positioning Attribute><Predictive Value><Process><Reading><Research><Research Personnel><Research Resources><Researchers><Resources><Role><San Francisco><Semantics><Series><Severities><Site><Social Behavior><Structure><Symptoms><Techniques><Testing><Therapeutic><Training><United States National Institutes of Health><Universities><analyzing longitudinal><behavioral variant FTD><behavioral variant frontotemporal degeneration><behavioral variant frontotemporal dementia><bio-markers><biologic marker><biomarker><brain atrophy><brain behavior><burden in caregivers><burden of their caregivers><burden on caregivers><bvFTD><career><career development><cerebellum degeneration><cerebral><cerebral atrophy><clinical predictors><cognitive defects><cognitive dysfunction><cognitive loss><cognitive neuroscience><cohort><computer based prediction><cortical atrophy><data resource><decline in function><decline in functional status><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><early detection><functional adaptation><functional decline><functional status decline><heavy metal Pb><heavy metal lead><imaging><improved><insight><longitudinal analysis><multi-modal neuro-imaging><multi-modality><multimodal neuroimaging><multimodality><network dysfunction><neural><neural degeneration><neural imaging><neural mechanism><neuro-imaging><neurodegeneration><neurodegenerative><neurodegenerative illness><neuroimaging><neuroimaging biomarker><neuroimaging marker><neurological degeneration><neurological imaging><neuromechanism><neuronal><neuronal degeneration><neuropsychiatric><neuropsychiatric symptom><neuropsychiatry><neuropsychologic><novel><patient oriented outcomes><predictive biological marker><predictive biomarkers><predictive marker><predictive modeling><predictive molecular biomarker><prognosis model><prognostic model><programs><psychiatric symptom><social><social cognition><social influence><social role><sociobehavior><sociobehavioral><theory of mind>
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Tracess Smalley

H. LEE MOFFITT CANCER CTR & RES INST, TAMPA, FL

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$113,234
FY 2026

Project Title

Dual E3 ligase function of TRIM25 in modulating innate immunity

Grant Number:

5K99GM154063-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2024

End Date:

1/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project summary/abstract Innate immunity is crucial for human health and is primarily regulated by post-translational modifications, such as ubiquitin and ubiquitin-like (ubl) modifiers. Specifically, Tripartite motif-containing protein 25 (TRIM25), is an E3 ligase that enzymatically modifies substr...

Research Terms

<APF-1><ATP-Dependent Proteolysis Factor 1><ATRA><Ablation><Address><Advisory Committees><Advocacy><Area><Assay><Award><Binding><Bioassay><Biochemistry><Biological Assay><Biological Chemistry><Biology><Cancer Center><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular biology><Communities><Coupling><DNA mutation><Data><Deubiquitination><Directed Molecular Evolution><E3 Ligase><E3 Ubiquitin Ligase><EFP Gene><EFP protein><Enzyme Gene><Enzymes><Esteroproteases><Estrogen-Responsive Finger Protein><Fostering><Genes><Genetic Change><Genetic defect><Genetic mutation><Glean><Goals><Grant><HMG-20><HPV><HPV E6><Health><High Mobility Protein 20><Human><Human Papilloma Virus><Human Papillomavirus><IFN><ISG15><ISG15 gene><Immune Precipitation><Immune signaling><Immunology><Immunoprecipitation><Infectious Human Wart Virus><Innate Immune Response><Innate Immunity><Institution><Interferon-Induced Protein IFI-15K><Interferons><Intracellular Communication and Signaling><Investigators><Knowledge><Leadership><Ligase><Ligase Gene><Maps><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Mentors><Modern Man><Modification><Molecular><Molecular Interaction><Mutation><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><Papillomavirus Transforming Protein E6><Pathway interactions><Peptidases><Peptide Hydrolases><Phase><Play><Polyubiquitination><Position><Positioning Attribute><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Process><Property><Protease Gene><Proteases><Protein Engineering><Protein Modification><Proteinases><Proteolytic Enzymes><Receptor Protein><Regulation><Research><Research Personnel><Research Resources><Researchers><Resources><Retinoic Acid><Role><Scientist><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Site><Substrate Specificity><Synthetases><System><TRIM25><TRIM25 gene><Task Forces><Testing><Training><Trans Vitamin A Acid><Tretinoin><Tretinoinum><Tripartite Motif-Containing Protein 25><Ubiquitilation><Ubiquitin><Ubiquitin Like Proteins><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitination><Ubiquitinoylation><Variant><Variation><Viral><Viral Activity><Viral Function><Viral Physiology><Viral Protein E6><Vitamin A Acid><Yeasts><ZNF147><Zinc Finger Protein 147><advisory team><all-trans-Retinoic Acid><all-trans-Vitamin A acid><antagonism><antagonist><biological signal transduction><career development><cell biology><conference><convention><design><designing><directed evolution><diversity, equity, and inclusiveness><equity, diversity, and inclusion><experience><genetic protein engineering><genome mutation><human papillomavirus E6 oncoprotein><innovate><innovation><innovative><insight><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><papilloma virus Transforming Protein E6><pathogenic virus><pathway><preference><programs><protein design><receptor><skill acquisition><skill development><social role><structural biology><summit><symposia><symposium><therapeutic agent development><therapeutic development><tool><trans-Retinoic Acid><ubiquination><ubiquitin conjugation><ubiquitin-protein ligase><viral pathogen><virology><virus pathogen><wart virus>
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Rebecca Ann Faulkner

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$111,249
FY 2026

Project Title

Elucidating the sterol-sensing mechanisms that regulate lipid metabolism.

Grant Number:

5K99GM154062-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

1/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Flux through the mevalonate (MVA) pathway is tightly controlled to ensure cells continuously synthesize nonsterol isoprenoids but avoid overproducing cholesterol and other sterols. Endoplasmic reticulum (ER)- localized HMG CoA reductase (HMGCR), the rate limiting enzyme in MVA pathw...

Research Terms

<1,1-Bisphosphonate Ester><20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><25-hydroxycholesterol><3-Hydroxy-3-methylglutaryl CoA Reductase><ACAT><ACAT enzyme><ASCVD><Acceleration><Acyl CoA><Acyl Coenzyme A><Acyl-CoA-Cholesterol Acyltransferase><AmB><AmBisome><Amphocil><Amphotec><Amphotercin B><Amphotericin B><Amphoterin><Amphoterin Gene><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Autoregulation><Basal Transcription Factor><Basal transcription factor genes><Binding><Binding Proteins><Biochemical><Blood Plasma><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cells><Chemistry><Cholesterol><Cholesterol Acyltransferase><Cholesterol Esterifying Enzyme><Chromosomal Protein, Nonhistone, HMG1><Chromosomal Protein, Nonhistone, HMG1 Gene><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complement><Complement Proteins><Complex><Coupled><Coupling><Cryo-electron Microscopy><Cryoelectron Microscopy><DNA mutation><Data><Development><Dimethylallyltransferase><Dimethylallyltranstransferase><Disease><Disorder><Dolichyl Phosphate Synthetase><Drugs><Electron Cryomicroscopy><Endoplasmic Reticulum><Ensure><Enzyme Gene><Enzymes><Ergastoplasm><Event><FM1 Gene Product><Farnesylpyrophosphate Synthetase><Fatty Acyl CoA><Feedback><Fungizone><Future><GGDP><GGPP cpd><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genomics><Geranylgeranyl Pyrophosphate Synthetase><Geranylpyrophosphate Synthetase><Goals><HMG CoA Reductases><HMG-1><HMG-1 Gene><HMG-1 Protein><HMG1><HMG1 Gene><HMG3><HMG3 Gene><HMGB1><HMGB1 Protein><HMGB1 gene><Heparin-Binding Protein p30><Hepatic><High Mobility Group Box Protein 1><High Mobility Group Protein 1><High Mobility Group Protein 1 Gene><High-Mobility Group (Nonhistone Chromosomal) Protein 1><High-Mobility Group (Nonhistone Chromosomal) Protein 1 Gene><High-Mobility Group Box 1><High-Mobility Group Box 1 Gene><Homeostasis><Hydroxymethylglutaryl-CoA reductase><Hypercholesteremia><Immune Precipitation><Immunoprecipitation><Incidence><Integral Membrane Protein><Intrinsic Membrane Protein><KI mice><Knock-in><Knock-in Mouse><Knock-out><Knockout><LDL><LDL Cholesterol><LDL Cholesterol Lipoproteins><LDL Lipoproteins><LDL Receptors><LDLR gene><Ligand Binding Protein><Ligand Binding Protein Gene><Lipids><Lipoprotein LDL Receptors><Liver><Long-Chain Acyl CoA><Low Density Lipoprotein Cholesterol><Low Density Lipoprotein Receptor><Low-Density Lipoproteins><Macropain><Macroxyproteinase><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Medication><Membrane><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Menaquinone><Mentors><Methylation><Mice><Mice Mammals><Molecular><Molecular Configuration><Molecular Conformation><Molecular Genetics><Molecular Interaction><Molecular Stereochemistry><Molecular Target><Monitor><Multicatalytic Proteinase><Murine><Mus><Mutation><Mysteclin-F><Nerylpyrophosphate Synthetase><Nonhistone Chromosomal Protein HGM1><Nonhistone Chromosomal Protein HGM1 Gene><Parents><Pathway interactions><Pharmaceutical Preparations><Phase><Photoaffinity Labels><Physiological Homeostasis><Plasma><Plasma Serum><Play><Post-Translational Regulation><Posttranslational Regulation><Prenyltransferase><Prevention therapy><Prosome><Proteasome><Proteasome Endopeptidase Complex><Protein Binding><Protein Cleavage><Protein Family><Proteins><Proteolysis><Proteosome><RNA Expression><Reaction><Regulation><Regulatory Element><Reporting><Research><Resistance><Reticuloendothelial System, Serum, Plasma><SBP-1><SBP-1 Gene><SR-45023A><Scientist><Short interfering RNA><Small Interfering RNA><Sterol O-Acyltransferase><Sterols><Sulfoglucuronyl Carbohydrate Binding Protein><Sulfoglucuronyl Carbohydrate Binding Protein Gene><Surface Proteins><System><Techniques><Therapeutic><Training><Transcription><Transcription Activation><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Activation><Transcriptional Control><Transcriptional Regulation><Transmembrane Protein><Transmembrane Protein Gene><Ubiquitilation><Ubiquitination><Ubiquitinoylation><Vitamin K 2><Vitamin K Quinone><Vitamin K2><Wild Type Mouse><acyl-CoA cholesterol acyltransferase><apomine><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><beta-Lipoprotein Cholesterol><beta-Lipoproteins><bound protein><career><cholest-5-ene-3 beta,25-diol><complementation><conformation><conformational><conformational state><conformationally><conformations><crosslink><cryo-EM><cryoEM><cryogenic electron microscopy><developmental><drug efficacy><drug/agent><fat metabolism><genome mutation><geranylgeraniol diphosphate><geranylgeranyl pyrophosphate><hepatic body system><hepatic organ system><high blood cholesterol><hypercholesterolemia><inhibitor><innovate><innovation><innovative><insight><interdisciplinary approach><interest><isoprenoid><knockin><knockin mice><lipid metabolism><membrane structure><mevalonate><multicatalytic endopeptidase complex><multidisciplinary approach><new approaches><novel><novel approaches><novel strategies><novel strategy><parent><pathway><prevent><preventing><professor><protein activation><resistant><siRNA><synthetic enzyme><transcription factor><ubiquination><ubiquitin conjugation><wildtype mouse>
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Magdalena Sevilla Gonzalez

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$90,000
FY 2026

Project Title

Integration of dietary factors and multi-omic signatures of genetic subtypes to understand diabetes heterogeneity

Grant Number:

5K99DK139461-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Type 2 diabetes (T2D) is a heterogeneous disease that is the result of the interaction between environmental and genetic factors. T2D heterogeneity has been described with a set of reproducible T2D genetic subtypes representing the contribution of specific pathways such as i...

Research Terms

<Adult-Onset Diabetes Mellitus><Affect><American><Amino Acids><Biological><Black Populations><Black group><Black individual><Black people><Blacks><Ch'i><Complex><Data><Diabetes Mellitus><Diagnosis><Diet><Dietary Factors><Dietary Intervention><Dietary Practices><Disease><Disorder><Doctor of Philosophy><Environment><Environmental Exposure><Environmental Factor><Environmental Risk Factor><Fats><Fatty acid glycerol esters><GI microbiome><Genetic><Genetic Diversity><Genetic Models><Genetic Variation><Genomics><Goals><Heterogeneity><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Individual><Insulin Resistance><Intermediary Metabolism><Intervention><Ketosis-Resistant Diabetes Mellitus><Lipids><Maturity-Onset Diabetes Mellitus><Measures><Mediating><Mediation><Mentorship><Metabolic><Metabolic Processes><Metabolism><Mission><Modeling><Modification><Molecular><Molecular Fingerprinting><Molecular Profiling><NIDDK><NIDDM><NIH><National Institute of Diabetes and Digestive and Kidney Diseases><National Institutes of Health><Negotiating><Negotiation><Non-Hispanic><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Nonhispanic><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Not Hispanic or Latino><Nutrient><Nutrition><Nutrition Interventions><Nutritional Interventions><Outcome><Pathway interactions><Patients><Ph.D.><PhD><Phase><Physiology><Population><Population Genetics><Population Heterogeneity><Position><Positioning Attribute><Precision Health><Process><Public Health><Qi><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized><Reproducibility><Research><Research Grants><Research Project Grants><Research Projects><Slow-Onset Diabetes Mellitus><Source><Stable Diabetes Mellitus><Strategic Planning><Subgroup><T2 DM><T2D><T2DM><TOPMed><Technology><Testing><Training><Trans-Omics for Precision Medicine><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States National Institutes of Health><Variant><Variation><Work><adult onset diabetes><aminoacid><biologic><career><clinical applicability><clinical application><clinical epidemiology><cohort><diabetes><diabetes genetics><diabetes mellitus genetics><diabetes risk><diet intervention><dietary pattern><diets><digestive tract microbiome><diverse populations><enteric microbiome><environmental risk><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><gastrointestinal microbiome><gene signatures><genetic signature><gut microbiome><gut-associated microbiome><heterogeneous population><human disease><improved><insulin resistant><insulin secretion><insulin tolerance><inter-individual variability><inter-individual variation><intestinal biome><intestinal microbiome><ketosis resistant diabetes><maturity onset diabetes><member><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><microbiome signature><molecular profile><molecular signature><multiomics><multiple omics><panomics><pathway><polygenetic risk scores><polygenic predictors><polygenic risk score><polygenic scores><population diversity><precision medicine><precision nutrition><precision-based medicine><prevent><preventing><programs><randomisation><randomization><randomly assigned><response><therapeutic target><type 2 DM><type II DM><type two diabetes>
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Fangtao Chi

MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CAMBRIDGE, MA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$90,000
FY 2026

Project Title

Enhancing intestinal regeneration with Cysteine mediated dietary intervention

Grant Number:

1K99DK146116-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract The small intestine, central to nutrient absorption like amino acids and lipids, houses highly responsive Lgr5+ intestinal stem cells (ISCs) in the crypt bottom. Over the past decade, our group and others have utilized the mouse intestine to investigate how dietary interven...

Research Terms

<Amino Acids><Anabolism><Autoregulation><Award><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Body Tissues><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><Cancers><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Growth and Maintenance><Cell Interaction><Cell Maintenance><Cell Signaling><Cell-to-Cell Interaction><Cells><Cellular Metabolic Process><Cholesterol><CoA><Coenzyme A><Complex><Coupled><Cues><Cysteine><Cystine><Diet><Dietary Intervention><Disease><Disorder><Education and Training><Environment><Epithelial Cells><Epithelium><Essential Amino Acids><Fasting><Food><GI Stem cell><Gene Expression><HG38><Half-Cystine><High Fat Diet><Homeostasis><IL-22><Immune><Immunes><In Vitro><Injections><Injury><Intestinal><Intestines><Intracellular Communication and Signaling><Intravenous><Investigators><KO mice><Ketone Bodies><Knock-out Mice><Knockout Mice><L-Cysteine><L-Cystine><LGR5><LGR5 gene><Lipids><LoxP-flanked allele><Lymphatic cell><Lymphocyte><Lymphocytic><Malignant Neoplasms><Malignant Tumor><Mediating><Metabolic><Metabolic Control><Metabolic Pathway><Metabolic dysfunction><Mice><Mice Mammals><Mitochondria><Modeling><Molecular><Murine><Mus><Natural regeneration><Null Mouse><Nutrient><Nutrition Interventions><Nutritional Interventions><Nutritional status><PPAR><PPAR alpha><PPAR delta><PPAR-α><PPAR-δ><PPARD protein><PPARalpha><PPARdelta><PPARα><PPARδ><Peroxisome Proliferator-Activated Receptor alpha><Peroxisome Proliferator-Activated Receptor delta><Peroxisome Proliferator-Activated Receptor α><Peroxisome Proliferator-Activated Receptor δ><Peroxisome Proliferator-Activated Receptors><Physiologic><Physiological><Physiological Homeostasis><Physiology><Play><Position><Positioning Attribute><Process><Production><Progenitor Cells><Pyruvate><Regeneration><Reporting><Research><Research Personnel><Research Resources><Researchers><Resources><Role><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Small Intestines><Source><System><T-Cell Depletion><T-Cells><T-Lymphocyte><T-cell depletion therapy><T-lymphocyte depletion therapy><T8 Cells><T8 Lymphocytes><Tail><Tamoxifen><Testing><Tissues><Training><Training and Education><Transplantation><Upregulation><Veins><aminoacid><biological signal transduction><biosynthesis><bowel><career development><cell metabolism><cell type><cellular metabaolism><crypt cell><cytokine><diet intervention><dietary><diets><experiment><experimental research><experimental study><experiments><fasted><fasts><feeding><floxed><floxed allele><gain of function><gastrointestinal homeostasis><gastrointestinal stem cell><gut progenitor><gut stem cell><in vivo><injuries><injury to the intestines><interleukin-22><intestinal crypt><intestinal epithelium><intestinal homeostasis><intestinal injury><intestinal progenitor><intestinal stem cells><ketogenesis><loss of function><lymph cell><malignancy><mesenteric lymph node><mesentery lymph node><mitochondrial><mouse model><murine model><neoplasm/cancer><novel><nutrient absorption><overexpress><overexpression><paracrine><progenitor cell fate><progenitor cell function><progenitor cell proliferation><progenitor cell regeneration><progenitor cell self renewal><progenitor fate><progenitor function><progenitor proliferation><progenitor regeneration><progenitor self renewal><programs><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><repair><repaired><response><self-renew><self-renewal><small bowel><social role><stem and progenitor cell fate><stem and progenitor cell function><stem and progenitor cell proliferation><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem and progenitor function><stem cell fate><stem cell function><stem cell proliferation><stem cell regeneration><stem cell self renewal><stem cells><sugar><thymus derived lymphocyte><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transplant><villin>
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Cora Smiley

UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA, COLUMBIA, SC

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$192,149
FY 2026

Project Title

Noradrenergic mechanisms underlying stress-induced opioid reinstatement

Grant Number:

1K99DA062785-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY The initiating factor for opioid use disorder often stems from comorbid neuropsychiatric conditions including anxiety, depression, and post-traumatic stress disorder. Experience of extreme or traumatic stress is often the underlying factor responsible for these neuropsychiatric condi...

Research Terms

<Address><Adrenergic Agents><Adrenergic Antagonists><Adrenergic Blockaders><Adrenergic Blockers><Adrenergic Drugs><Adrenergic Receptor Antagonists><Adrenergic Receptor Blockaders><Adrenergic-Blocking Agents><Adrenergics><Adrenolytic Agents><Adrenolytic Drugs><Adrenolytics><Affect><Anti-Adrenergics><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-adrenergic Agents><Anti-inflammatory><Antiadrenergic Agents><Antiadrenergics><Anxiety><Area><Arousal><Automobile Driving><Behavior><Behavioral><Beta Proprotein Interleukin 1><Brain><Brain Nervous System><Causality><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Clinical><Common Rat Strains><Cues><Data><Dopamine><Drug Controls><Drug abuse><Drugs><Electrophysiology><Electrophysiology (science)><Encephalon><Etiology><Exposure to><Extinction><Female><Fiber><Genetic><Genetic Suppression><Genetic Technics><Genetic Techniques><Goals><Hortega cell><Human><Hydroxytyramine><IL-1 beta><IL-1 β><IL-1-b><IL-1β><IL1-Beta><IL1-β><IL1B Protein><IL1F2><IL1β><Immune><Immunes><Initiation Factors><Injections><Interleukin 1beta><Interleukin-1 beta><Interleukin-1β><Intracellular Communication and Signaling><Investigation><Laboratories><Levarterenol><Levonorepinephrine><Locus Coeruleus><Medial><Mediating><Medication><Mental Depression><Mental disorders><Mental health disorders><Microglia><Modeling><Modern Man><Monitor><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neurobiology><Neurocyte><Neuroimmune><Neuronal Transmission><Neurons><Neurophysiology / Electrophysiology><Noradrenaline><Norepinephrine><Nucleus Accumbens><Nucleus Pigmentosus Pontis><Opiates><Opioid><Oral><PTSD><Peptide Initiation Factors><Pharmaceutical Agent><Pharmaceutical Preparations><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Phenotype><Photometry><Play><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Prefrontal Cortex><Preinterleukin 1 Beta><Preventative strategy><Prevention strategy><Preventive strategy><Property><Psychiatric Disease><Psychiatric Disorder><Psychosocial Stress><Public Health><Rat><Rats Mammals><Rattus><Relapse><Research><Rewards><Role><Self Administered><Self Administration><Signal Transduction><Signal Transduction Systems><Signaling><Stimulus><Stress><Substance Use Disorder><Symptoms><Techniques><Testing><Therapeutic><Time><Training><Translation Initiation Factor><Translational Initiation Factor><Virus><abuse of drugs><abuses drugs><adverse consequence><adverse outcome><alpha-adrenergic receptor><axon signaling><axon-glial signaling><axonal signaling><biological adaptation to stress><biological signal transduction><blue nucleus><career development><causation><co-morbid><co-morbidity><comorbidity><cytokine><depression><design><designing><disease causation><driving><drug seeking behavior><drug/agent><electrophysiological><experience><experiment><experimental research><experimental study><experiments><gitter cell><glia signaling><glial signaling><in vivo><innervation><innovate><innovation><innovative><locus ceruleus structure><male><mental illness><mesoglia><microglial cell><microgliocyte><nerve signaling><nerve supply><neural circuit><neural circuitry><neural mechanism><neural signaling><neurobiological><neurocircuitry><neuromechanism><neuronal><neuronal signaling><neuropsychiatric><neuropsychiatry><neurotransmission><non-medical opioid use><nonmedical opioid use><noradrenergic><novel><opiate abuse><opiate consumption><opiate crisis><opiate drug abuse><opiate drug use><opiate intake><opiate misuse><opiate use><opiate use disorder><opioid abuse><opioid consumption><opioid crisis><opioid drug abuse><opioid drug use><opioid epidemic><opioid intake><opioid misuse><opioid use><opioid use disorder><oxycodone seeking><perivascular glial cell><pharmaceutical><pharmacologic><post-trauma stress disorder><posttrauma stress disorder><pre-clinical><preclinical><prevent><preventing><programs><psychiatric illness><psychological disorder><reactioncrisis><response><sensor><social role><social stress><socially stressed><stem><stress response><stressreaction><substance misuse><substance use and disorder><synaptic circuit><synaptic circuitry><tool><traumatic event><traumatic neurosis><traumatic stress><treatment strategy><α-adrenergic receptor><♀><♂>
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Jessica N. Flori

UNIVERSITY OF CONNECTICUT SCH OF MED/DNT, FARMINGTON, CT

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$191,700
FY 2026

Project Title

Mechanisms of Action of Peer Recovery Support for People Receiving Opioid Use Disorder Treatment

Grant Number:

1K99DA062786-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Abstract The proposed K99/R00 award aims to guide the applicant to research independence, specifically in mechanisms of action (MoA) research of recovery support services for substance use disorders. The opioid epidemic is an ongoing public health crisis with opioid-related overdose deaths continuin...

Research Terms

<Action Research><Active Follow-up><Address><American><Area><Award><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Caring><Cell Communication and Signaling><Cell Signaling><Certification><Client><Clinical Trials><Collaborations><Communities><Conditioning Therapy><Consensus><Data><Data Analyses><Data Analysis><Development><Development Plans><Dropout><Drops><Drugs><Education><Educational aspects><Educational workshop><Epidemic><Evaluation><Feedback><Foundations><Future><Goals><Grant><Individual><Intervention><Interview><Intracellular Communication and Signaling><Investigators><Literature><Lived experience><Lived experiences><Measures><Medication><Mentors><Methodology><Methods><Modeling><Opiates><Opioid><Outcome><Overdose><Participant><Patient Self-Report><Patients><Persons><Pharmaceutical Preparations><Phase><Postdoc><Postdoctoral Fellow><Procedures><Process><Program Effectiveness><Protocol><Protocols documentation><Public Health><Randomized><Randomized, Controlled Trials><Recovery><Recovery Support><Research><Research Associate><Research Personnel><Researchers><Risk><Sampling><Self-Report><Services><Signal Transduction><Signal Transduction Systems><Signaling><Specialist><Substance Use Disorder><Testing><Training><Treatment outcome><Work><Workshop><Writing><acceptability and feasibility><active followup><behavior intervention><behavioral intervention><biological signal transduction><career><career development><collaboration with communities><community based participatory approach><community based participatory design><community based participatory method><community based participatory process><community based participatory research><community clinic><community collaboration><community led research><community participatory approach><community participatory design><community participatory method><community participatory model><community participatory research><community partnered participatory research><community setting><community-based collaboration><data interpretation><design><designing><developmental><drug/agent><effective therapy><effective treatment><efficacy trial><experience><feasibility testing><follow up><follow-up><followed up><followup><hands on research><human centered design><illicit opiate><illicit opioid><improved><improved outcome><insight><intervention effect><medication-assisted therapy><medication-assisted treatment><meeting><meetings><member><mortality><novel><opiate consumption><opiate crisis><opiate drug use><opiate intake><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid crisis><opioid drug overdose><opioid drug use><opioid epidemic><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><overdose death><overdose fatalities><overdose risk><participatory action research><patient retention><peer><peer recovery><post-doc><post-doctoral><post-doctoral trainee><programs><randomisation><randomization><randomized control trial><randomly assigned><recovery services><recovery support services><recruit><research associates><skills><sober><sobriety><standard care><standard treatment><substance use and disorder><substance use treatment><tool><treatment program><trial comparing>
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Rafael E Perez

YALE UNIVERSITY, NEW HAVEN, CT

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$181,040
FY 2026

Project Title

Role of Anterior Cingulate Cortex Ensemble Regulation of Spinal Cord Excitability in Associative Opioid Analgesic Tolerance.

Grant Number:

5K99DA060951-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/15/2024

End Date:

12/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary Opioid medications are highly prescribed for pain management. However, these drugs have considerable abuse liability. As users increase their opioid intake, they build tolerance against their therapeutic effects. Despite well- described molecular and cellular mechanisms, tolerance ca...

Research Terms

<Academic skills><Acute><Address><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Animals><Anodynes><Anterior><Antinociceptive Agents><Antinociceptive Drugs><Automobile Driving><Behavior><Behavioral><Brain><Brain Nervous System><Brain region><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chronic><Data><Development><Dorsal><Drugs><Encephalon><Environment><Fiber><Foundations><Genetic><Goals><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Intracellular Communication and Signaling><Investigators><Knowledge><Laboratories><Laboratory Research><Learning><Mediating><Medication><Medulla Spinalis><Mentors><Mentorship><Mice><Mice Mammals><Modeling><Molecular><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurocyte><Neurons><Nociception><Opiates><Opioid><Opioid Analgesics><Optics><Overdose><Pain><Pain Control><Pain Therapy><Pain management><Painful><Pathway interactions><Peripheral><Pharmaceutical Preparations><Pharmacology><Phase><Photometry><Physiologic><Physiological><Play><Procedures><Process><Regulation><Research Personnel><Researchers><Risk><Role><Scientific Advances and Accomplishments><Signal Transduction><Signal Transduction Systems><Signaling><Site><Spinal><Spinal Cord><Technical Expertise><Techniques><Testing><Therapeutic Effect><Tracer><Training><Transgenic Organisms><Viral><abuse liability><abuse potential><addiction><addictive disorder><behavioral pharmacology><biological signal transduction><career><career development><cell type><cingulate cortex><developmental><driving><drug/agent><experiment><experimental research><experimental study><experiments><genetic approach><genetic strategy><in vivo><insight><licit opioid><neural><neuronal><nociceptive><novel><opiate analgesia><opiate analgesic><opiate consumption><opiate drug use><opiate intake><opiate medication><opiate overdose><opiate pain medication><opiate pain reliever><opiate related overdose><opiate use><opiate use disorder><opioid analgesia><opioid anesthetic><opioid consumption><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication><opioid medication overdose><opioid overdose><opioid pain medication><opioid pain reliever><opioid painkiller><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><optical><optogenetics><overdose death><overdose fatalities><pain intervention><pain killer><pain medication><pain reliever><pain treatment><painkiller><pathway><pharmacobehavioral><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><prevent><preventing><professor><response><scientific accomplishments><scientific advances><social role><technical skills><tool><transgenic>
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Xinyuan Zhang

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$165,883
FY 2026

Project Title

Inflammation and Hepatocellular Carcinoma: A Multiomics Approach to Improve Early Detection, Causal Inference, and Lifestyle Based Prevention

Grant Number:

5K99CA296755-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Dr. Xinyuan (Cindy) Zhang’s long-term goal is to become an independent and active researcher in the field of cancer molecular epidemiology that contributes to the development of novel strategies for cancer prevention and early diagnosis. Hepatocellular carcinoma (HCC) is hig...

Research Terms

<AFP><AFP gene><Address><African American><Afro American><Afroamerican><Age><Alpha-1-Fetoprotein><Alpha-Fetoglobulin><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Area Under Curve><Award><Biological><Biological Markers><Blood Plasma><Blood Serum><Cancer Cause><Cancer Control Research><Cancer Etiology><Cancers><Career Mobility><Causality><Chronic><Cirrhosis><Clinical><Cohort Studies><Colon or Rectum><Colorectal><Communities><Computational Biology><Data><Death Rate><Development><Diagnosis><Diagnostic><Diet><Early Diagnosis><Enrollment><Epidemiological data><Epidemiology data><Etiology><FETA><Female Health><Fetuins><Follow-Up Studies><Future><Genetic><Genetic Risk><Genomic approach><Genomics><Goals><HPAFP><Health><Health Care Professional><Health Professional><Health behavior><Hepatic Cancer><Hepatic Cirrhosis><Hepatocarcinoma><Hepatocarcinoma model><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatoma><Hispanic><Image><Incidence><Inflammation><Inflammatory><Investigators><Israel><Knowledge><Lectin><Life Style><Lifestyle><Link><Liver Cells Carcinoma><Liver Cirrhosis><Lung><Lung Respiratory System><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of liver><Maps><Mendelian randomization><Mentors><Metabolic dysfunction><Modeling><Molecular><Molecular Epidemiology><Molecular Epidemiology of Cancer><Nested Case-Control Study><Nurses' Health Study><Outcomes Research><Ovarian><PIVKA-II><Participant><Pathway interactions><Patients><Pattern><Performance><Physicians><Pilot Projects><Plasma><Plasma Serum><Predicting Risk><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Primary Prevention><Primary carcinoma of the liver cells><Prospective cohort><Prostate><Prostate Gland><Prostatic Gland><Proteins><Proteomics><Public Health><QTL><Quantitative Trait Loci><Recommendation><Research><Research Design><Research Personnel><Research Resources><Researchers><Resources><Reticuloendothelial System, Serum, Plasma><Risk><Risk Assessment><Risk Estimate><Risk Factors><Role><Sampling><Serum><Study Type><Systems Biology><Testing><Training><Training Activity><Translating><Validation><Women's Health><acarboxy prothrombin><acarboxyprothrombin><ages><bio-markers><biobank><biologic><biologic marker><biomarker><biorepository><cancer biomarkers><cancer epidemiology><cancer markers><cancer prevention><career><career advancement><career transition><causation><cirrhotic><cohort><cohort research study><cohort survey><colorectum><computer based prediction><computer biology><data to train><dataset to train><decarboxyprothrombin><des-gamma-carboxy prothrombin><descarboxylated prothrombin><descarboxyprothrombin><detection method><detection procedure><detection technique><developmental><dietary><diets><disease causation><early detection><enroll><epidemiologic data><epidemiology research study><epidemiology study><epidemiology survey><follow-up research study><follow-up survey><forecasting risk><genomic data><genomic dataset><genomic effort><genomic strategy><health related behavior><hepatocellular carcinoma cancer model><hepatocellular carcinoma model><high risk><high risk group><high risk individual><high risk people><high risk population><imaging><improved><inflammation marker><inflammatory marker><innovate><innovation><innovative><insight><liver cancer><liver cancer model><liver carcinoma><liver malignancy><machine learning based method><machine learning method><machine learning methodologies><malignancy><malignant liver tumor><mortality><mortality rate><multiomics><multiple omics><neoplasm/cancer><new approaches><new marker><non-carboxylated factor II><novel><novel approaches><novel biomarker><novel marker><novel strategies><novel strategy><panomics><pathway><patient registry><pilot study><population based><pre-blood-coagulation factor II><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive modeling><predictive risk><predicts risk><prospective><protein biomarkers><protein markers><protein protein interaction><proteomic signature><risk prediction><risk predictions><screening><screenings><sex><skills><social role><study design><study with follow-up><success><time to event><time to occurrence><training data><training module><validations><α-Fetoproteins>
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Jaeyop Lee

SLOAN-KETTERING INST CAN RESEARCH, NEW YORK, NY

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$154,642
FY 2026

Project Title

Targeting the evolving immunopeptidome of metastatic colorectal cancer

Grant Number:

5K99CA297011-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Targeting the evolving immunopeptidome of metastatic colorectal cancer There has been limited success of chimeric antigen receptor (CAR) T cell therapies in solid tumors, in part, due to the inability to identify cancer-specific targets. Exploring the immunopeptidome, peptides presented by human leu...

Research Terms

<21+ years old><Address><Adopted><Adult><Adult Human><Advanced Cancer><Advanced Malignant Neoplasm><Alleles><Allelomorphs><Antigens><Biological><Blood><Blood Reticuloendothelial System><Body Tissues><CAR T cell therapy><CAR T cells><CAR T therapy><CAR modified T cells><CAR-T><CAR-Ts><Cancer Patient><Cancers><Cause of Death><Cell Body><Cell Therapy><Cell surface><Cells><Cellular immunotherapy><Class I Antigens><Class I Major Histocompatibility Antigens><Clinical><Collection><Colon><Colon Cancer><Colon Carcinoma><Colorectal Cancer><Complex Class 1><DNA mutation><Data><Development><Disease><Disorder><Drugs><Epithelium><Exclusion><Exhibits><Expression Signature><Foundations><Gene Expression Profile><Gene Transcription><Genes><Genetic><Genetic Change><Genetic Heterogeneity><Genetic Transcription><Genetic defect><Genetic mutation><Genomics><HL-A Antigens><HLA Antigens><HLA testing><HLA typing><Heterogeneity><Heterograft><Heterologous Transplantation><Histocompatibility Antigens Class I><Human><Human Cloning><Human Leukocyte Antigens><Immune><Immunes><Immunooncology><In Vitro><Intestinal><Intestines><Invaded><Investigators><Knowledge acquisition><Leadership><Lentiviral Vector><Lentivirus Vector><Leukocyte Antigens><MHC Class I Molecule><MHC Class I Protein><MHC Receptor><MHC class I antigen><MSKCC><Major Histocompatibility Complex Class 1><Major Histocompatibility Complex Receptor><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Medical Oncology><Medication><Memorial Sloan-Kettering Cancer Center><Mentorship><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Microsatellite Markers><Microsatellite Repeats><Microsatellites><Modern Man><Morphology><Mutation><Neoplasm Metastasis><Oncogenic><Organ><Organoids><Pathway interactions><Patients><Peptides><Pharmaceutical Preparations><Phenotype><Physicians><Primary Lesion><Primary Neoplasm><Primary Tumor><Proliferating><Proteins><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Research><Research Personnel><Research Specimen><Researchers><Resected><Resistance><Role><Sampling><Scientist><Secondary Neoplasm><Secondary Tumor><Site><Solid Neoplasm><Solid Tumor><Specimen><Stereotyping><Stromal Cells><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell directed therapies><T cell immune therapy><T cell immunotherapy><T cell receptor based immunotherapy><T cell receptor cellular immunotherapy><T cell receptor engineered therapy><T cell receptor immunotherapy><T cell receptor repertoire sequencing><T cell receptor sequencing><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cells for CAR><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-Cell Antigen Receptors><T-Cell Development><T-Cell Ontogeny><T-Cell Receptor><T-Cell Receptor Therapy><T-Cell Receptor Treatment><T-Cell Receptor based Therapy><T-Cell Receptor based Treatment><T-Cells><T-Lymphocyte><T-Lymphocyte Development><T-cell therapeutics><T-cell transfer therapy><TCR T cell immunotherapy><TCR T cell therapy><TCR Therapy><TCR based T cell immunotherapy><TCR based Therapy><TCR based immune therapy><TCR based immunotherapy><TCR based treatment><TCR immunotherapy><TCR repertoire sequencing><TCR sequencing><TCR-seq><TCRseq><Techniques><Testing><Therapeutic><Therapeutic Intervention><Therapeutic Uses><Thymus><Thymus Gland><Thymus Proper><Thymus Reticuloendothelial System><Tissues><Toxic effect><Toxicities><Transcription><Translating><WNT Signaling Pathway><WNT signaling><Xenograft><Xenograft Model><Xenograft procedure><Xenotransplantation><adenoma><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><adulthood><advanced disease><advanced illness><biologic><bowel><cancer cell><cancer in the colon><cancer metastasis><cancer progression><cancer surgery><cell based intervention><cell mediated intervention><cell mediated therapies><cell-based immunotherapy><cell-based therapeutic><cell-based therapy><cellular targeting><cellular therapeutic><cellular therapy><chimeric antigen T cell receptor><chimeric antigen receptor (CAR) T cell therapy><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cell therapy><chimeric antigen receptor T cells><chimeric antigen receptor T therapy><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><clinical heterogeneity><clinical relevance><clinically relevant><colon cancer patients><colorectal cancer patients><develop therapy><developmental><drug/agent><engineered T cells><extracellular><fetal><gene expression pattern><gene expression signature><genetically engineered T-cells><genome mutation><human leukocyte antigen testing><human leukocyte antigen typing><immune cell therapy><immune-oncology><immuno oncology><immunogen><immunogenicity><immunology oncology><in vivo><inhibitor><insight><intervention development><intervention therapy><knock-down><knockdown><malignancy><metastatic colo-rectal><metastatic colo-rectal cancer><metastatic colo-rectal carcinoma><metastatic colon cancer><metastatic colorectal><metastatic colorectal cancer><metastatic colorectal carcinoma><mouse model><multi-modality><multimodality><murine model><neoplasm progression><neoplasm/cancer><neoplastic progression><novel><oncoimmunology><pathway><patient retention><peptide aminoacid sequence><peptide sequence><peripheral blood><programs><protein aminoacid sequence><resistant><response><skills><social role><success><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic T-cell platform><therapy development><thymus derived lymphocyte><transcriptional profile><transcriptional signature><transcriptome sequencing><transcriptomic sequencing><transcriptomics><transgenic T- cells><treatment development><tumor><tumor cell metastasis><tumor progression><xeno-transplant><xeno-transplantation><xenograft transplant model><xenotransplant model>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sean Christopher Piantadosi

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$148,403
FY 2026

Project Title

The role of valence encoding amygdala ensembles in avoidance behavior

Grant Number:

5K99DA062328-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY The ability of an organism to rapidly and accurately assess whether an environmental stimulus is worth approaching or avoiding, also known as valence, is critical to survival. One brain region necessary for this computation is the basolateral amygdala (BLA), which contains discrete e...

Research Terms

<2-photon><Acute><Address><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Anatomic Sites><Anatomic structures><Anatomy><Anxiety><Automobile Driving><Aversive Stimulus><Behavior><Behavioral><Behavioral Assay><Biosensor><Brain><Brain Nervous System><Brain region><Calcium><Catecholamine Receptor><Causality><Cell Communication and Signaling><Cell Signaling><Chronic><Color><Complex><Computer Analysis><Computer Models><Computerized Models><Connector Neuron><Consumption><Development><Disease><Disorder><Dissection><Emotional><Encephalon><Etiology><Fiber><Foundations><Future><Glutamates><Holography><Image><Implant><Individual><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intracellular Communication and Signaling><L-Glutamate><Laboratories><Learning><Levarterenol><Levonorepinephrine><Link><Locus Coeruleus><Maps><Measures><Mediating><Modality><Negative Valence><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic Disorders><Neurological Disorders><Neurons><Noradrenaline><Norepinephrine><Nucleus Pigmentosus Pontis><Opsin><Organism><Output><Parvalbumins><Pathological anxiety><Pattern><Pharmacology><Photometry><Photons><Position><Positioning Attribute><Positive Valence><Pyramidal neuron><Resolution><Rewards><Risk><Rod-Opsin><Role><Running><Signal Transduction><Signal Transduction Systems><Signaling><Stimulus><Stress><Technology><Testing><Training><acute stress><amygdaloid nuclear complex><antagonism><antagonist><anxiety-like behavior><avoidance behavior><behavior test><behavioral test><beta-2 Adrenergic Receptors><biological sensor><biological signal transduction><blue nucleus><causation><computational analyses><computational analysis><computational modeling><computational models><computer analyses><computer based models><computerized modeling><developmental><disease causation><driving><fluorescence imaging><fluorescent imaging><glutamatergic><graph theory><hippocampal pyramidal neuron><image registration><imaging><in vivo><lens><lenses><living system><locus ceruleus structure><monoamine><multi-photon><multi-photon imaging><multiphoton imaging><neural><neural control><neural regulation><neurological disease><neuromodulation><neuromodulatory><neuronal><neuropsychiatric disease><neuropsychiatric disorder><neuroregulation><noradrenergic><novel><optogenetics><photoactivation><recruit><redshift><resolutions><response><severe anxiety><social role><spatial and temporal><spatial temporal><spatiotemporal><stressor><two-photon><β-2 Adrenoceptor><β2 Adrenergic Receptor>
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Maria Hakonen

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$134,730
FY 2026

Project Title

Subtyping tinnitus based on fMRI dynamic functional connectivity

Grant Number:

5K99DC022305-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Why this may be worth a closer look

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Project Abstract

Project summary Subjective tinnitus is a sensation of ringing or other noise perceived without external sound. People with tinnitus often experience comorbidities, such as hearing, mental, and sleep problems. Thus, tinnitus can substantially decrease quality of life and is a major socioeconomic burd...

Research Terms

<ASD><Address><Affect><Age><Area><Audiogram><Audiometric Test><Audiometry><Auditory><Auditory Cortex><Auditory area><Autism><Autistic Disorder><Big Data><BigData><Biological Markers><Biomedical Engineering><Brain><Brain Nervous System><Brain region><Causality><Cell Nucleus><Characteristics><Classification><Clinic><Clinical><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complement><Complement Proteins><Data><Data Set><Development><Diagnosis><Disease><Disorder><Distress><Disturbance in cognition><Ear><Early Infantile Autism><Economic Burden><Encephalon><Environment><Esthesia><Etiology><Eye><Eyeball><Functional MRI><Functional Magnetic Resonance Imaging><Goals><Health><Hearing><Hearing Loss><Hearing Tests><Hyperacusia><Hyperacusis><Hypoacuses><Hypoacusis><Impaired cognition><Individual><Infantile Autism><Inferior Colliculus><Intervention><Investigation><Kanner's Syndrome><Knowledge><Loudness><Loudness Perception Disturbances><Loudness Recruitment><Machine Learning><Massachusetts><Measures><Medial><Mental Depression><Mental Health><Mental Hygiene><Mentors><Methods><Modeling><Network Analysis><Neurosciences><Noise><Nucleus><Olives><Olives - dietary><Participant><Pathway Analysis><Patients><Pattern><Persons><Phase><Population><Posterior Quadrigeminal Body><Prediction of Response to Therapy><Prevalence><Psyche structure><Psychoacoustics><Psychological Health><QOL><Quality of life><Questionnaires><Reporting><Research><Resolution><Rest><Ringing-Buzzing-Tinnitus><Role><Sample Size><Sampling><Sensation><Severities><Sleep Disorders><Structure><Subjective Tinnitus><Systematics><Techniques><Testing><Time><Tinnitus><Treatment outcome><Variant><Variation><accurate diagnosis><ages><auditory nuclei><auditory pathway><auditory processing><auditory tests><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><bio-engineered><bio-engineers><bio-markers><biobank><bioengineering><biologic marker><biological engineering><biomarker><biomedical imaging><biorepository><brain behavior><causation><co-morbid><co-morbidity><cognitive dysfunction><cognitive loss><comorbidity><complementation><decreased loudness tolerance><depression><developmental><disease causation><dysfunctional hearing><experience><fMRI><hearing assessment><hearing challenged><hearing defect><hearing deficient><hearing deficit><hearing difficulty><hearing dysfunction><hearing impairment><inter-individual variability><inter-individual variation><loudness intolerance><machine based learning><machine learning based method><machine learning method><machine learning methodologies><mental><neural><neural imaging><neural mechanism><neuro-imaging><neuroimaging><neuroimaging biomarker><neuroimaging marker><neurological imaging><neuromechanism><new approaches><noise sensitivity><novel approaches><novel strategies><novel strategy><optimal therapies><optimal treatments><outcome prediction><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><predict therapeutic response><predict therapy response><programs><resolutions><response><sex><skills><sleep diseases><sleep dysfunction><sleep illness><sleep problem><social role><socio-economic><socio-economically><socioeconomically><socioeconomics><sound><spatial and temporal><spatial temporal><spatiotemporal><speech processing><super high resolution><superresolution><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapy prediction><tinnitus aurium><treatment prediction><treatment response prediction><treatment strategy><ultra high resolution>
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Megan Anne Kirchgessner

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$134,109
FY 2026

Project Title

Plasticity and social neuromodulation of developing auditory cortical circuits

Grant Number:

1K99DC022676-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/19/2025

End Date:

11/30/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Postnatal development is a formative time for animals like humans and rodents that are born immature, dependent upon caretakers for survival and with brains that are still growing and changing. Many of these changes are subject to environmental influence, such that the chara...

Research Terms

<2-photon><21+ years old><ARHGEF5><ARHGEF5 gene><Acetylcholine><Acoustics><Adult><Adult Human><Advisory Committees><Affect><Afferent Neurons><Animals><Audiogram><Audiometric Test><Audiometry><Auditory><Auditory Cortex><Auditory area><Axon><Brain><Brain Nervous System><CNS plasticity><Calcium><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Characteristics><Cues><Cyclic Somatostatin><Data><Development><Disinhibition><Electrophysiology><Electrophysiology (science)><Encephalon><Endogenous Factors><Environment><Environmental Factor><Environmental Risk Factor><Exposure to><Faculty><GEF5><Genetic><Goals><Growth Hormone Inhibiting Factors><Growth Hormone-Inhibiting Hormone><Hearing><Hearing Disorders><Hearing Tests><Hearing problem><Human><Image><In Vitro><Individual><Institution><Intracellular Communication and Signaling><Laboratories><Language><Life><Methods><Mice><Mice Mammals><Modern Man><Monitor><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neurocyte><Neuromodulator><Neuronal Plasticity><Neurons><Neurophysiology / Electrophysiology><Ocytocin><Optical Methods><Optics><Oxytocin><P60><Perception><Phase><Play><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Recombinant Oxytocin><Research><Research Associate><Rodent><Rodentia><Rodents Mammals><Role><SRIH><SRIH-14><Sensory><Sensory Neurons><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Slice><Social Environment><Social isolation><Somatostatin><Somatostatin-14><Somatotropin Release Inhibiting Factors><Somatotropin Release-Inhibiting Hormone><System><Systems Development><TIM1><Task Forces><Testing><Time><Training><Whole-Cell Recordings><adulthood><advisory team><auditory disease><auditory disorder><auditory dysfunction><auditory problem><auditory tests><biological signal transduction><care giving><care providers><caregiving><cell cortex><cell type><central nervous system plasticity><cholinergic><critical period><developmental><developmental plasticity><electrophysiological><environmental risk><excitatory neuron><experience><experiment><experimental research><experimental study><experiments><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><growth hormone release inhibiting factor><hearing assessment><hearing disease><high dimensional data><imaging><imaging approach><imaging based approach><in vivo><inhibitory neuron><insight><juvenile animal><longitudinal imaging><medical college><medical schools><multidimensional data><multidimensional datasets><neural><neural control><neural plasticity><neural regulation><neurodevelopment><neuromodulation><neuromodulatory><neuronal><neuroplastic><neuroplasticity><neuroregulation><novel><optical><patch clamp><post-doc><post-doctoral><post-doctoral trainee><post-natal development><post-natal period><postnatal><postnatal development><postnatal period><programs><pup><research associates><response><school of medicine><serial imaging><social><social climate><social context><social role><socioenvironment><socioenvironmental><sound><statistics><two-photon><young animal>
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Mariana Rodriguez Santiago

COLORADO STATE UNIVERSITY, FORT COLLINS, CO

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$130,680
FY 2026

Project Title

Hormone-Mediated Plasticity within Central Auditory Circuits

Grant Number:

5K99DC022342-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/10/2024

End Date:

11/30/2026

Why this may be worth a closer look

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Project Abstract

PROJECT SUMMARY/ABSTRACT This proposal will causally test how hormones affect the development and activation of the neural circuitry that drives auditory processing. In humans and other vertebrates, major life transitional events such as development and reproduction are driven by changes in levels o...

Research Terms

<0-11 years old><21+ years old><Acoustics><Acute><Adult><Adult Human><Affect><Age><Aquadiol><Area><Auditory><Auditory Threshold><Auditory system><Basic Research><Basic Science><Behavior><Biological><Brain><Brain Nervous System><Brain region><Cell Body><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cells><Cellular Proliferation><Child><Child Youth><Children (0-21)><Cues><Development><Dimenformon><Diogyn><Diogynets><Disease><Disorder><Electrophysiology><Electrophysiology (science)><Encephalon><Endocrine Gland Secretion><Environment><Estrace><Estradiol><Estradiol-17 beta><Estradiol-17beta><Estraldine><Estrogens><Event><Exposure to><Frog><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Genes><Glucocorticoids><Goals><Gonadal Steroid Hormones><Growth Agents><Growth Factor><Growth Substances><Health Care Costs><Health Costs><Hearing><Hearing Loss><Hormonal><Hormonal Change><Hormones><Human><Hypoacuses><Hypoacusis><Hypothalamic structure><Hypothalamus><Infant Development><Inferior Colliculus><Internal Ear><Investigation><Knowledge><Labyrinth><Life><Mediating><Mentors><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><NIDCD><National Institute on Deafness and Other Communication Disorders><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuroendocrine><Neuroendocrine System><Neurons><Neurophysiology / Electrophysiology><Neurosecretory Systems><Ovocyclin><Ovocylin><Pathway interactions><Pattern><Peripheral><Phase><Physiologic><Physiological><Play><Population><Posterior Quadrigeminal Body><Preoptic Areas><Process><Progynon><Proteins Growth Factors><QOL><QOL improvement><Quality of life><RNA Seq><RNA sequencing><RNAseq><Rana><Receptor Protein><Reproduction><Reproductive Behavior><Research><Role><Sex Hormones><Sex Steroid Hormones><Shapes><Specialist><Strategic Planning><Supporting Cell><System><Systems Development><Techniques><Testing><Testosterone><Therapeutic Estradiol><Therapeutic Estrogen><Therapeutic Hormone><Therapeutic Intervention><Therapeutic Testosterone><Thyroid Gland Hormone><Thyroid Hormones><Time><Trans-Testosterone><United States><Vertebrate Animals><Vertebrates><Woman><Work><adulthood><ages><auditory processing><behavior response><behavioral response><biologic><childhood hearing loss><class development><cochlear development><course development><course material development><deafness><developmental><dysfunctional hearing><early hearing loss><electrophysiological><experience><experiment><experimental research><experimental study><experiments><extracellular><functional plasticity><gonadal steroids><hearing challenged><hearing defect><hearing deficient><hearing deficit><hearing difficulty><hearing dysfunction><hearing impairment><hearing loss in children><hearing threshold><hormonal regulation><hormonal signals><hormone regulation><hormone signals><hypothalamic><improvements in QOL><improvements in quality of life><in vivo><inner ear><insight><intervention therapy><kids><men><molecular profile><molecular signature><neural><neural circuit><neural circuitry><neural mechanism><neurocircuitry><neuromechanism><neuronal><novel><pathway><pediatric hearing loss><pharmacologic><preoptic region><programs><quality of life improvement><receptor><reproductive><response><sensory system><sex><sex steroid><skills><social role><synaptic circuit><synaptic circuitry><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transcriptome sequencing><transcriptomic sequencing><vertebrata><youngster>
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Yan Zhang

CALIFORNIA INSTITUTE OF TECHNOLOGY, PASADENA, CA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$128,461
FY 2026

Project Title

AN ADAPTIVE FRAMEWORK TO SYNTHESIZE AND RECONFIGURE BACTERIAL VIRUSES (PHAGES) TO COUNTER ANTIBIOTIC RESISTANCE

Grant Number:

5K99EB036553-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY The growing antibiotic resistance crisis has revived interest in using phage therapy (viruses that infect and lyse bacteria) to treat drug-resistant, pathogenic infections. Despite its promise, current phage therapy development faces significant challenges in scalability and accessi...

Research Terms

<Acceleration><Address><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotics><Award><Bacteria><Bacteriophages><Cell Body><Cell-Free System><Cellfree System><Cells><Chrysemonas><Code><Coding System><Coliform Bacilli><Cytolysis><DNA><Deoxyribonucleic Acid><Development><Distant><Drug resistance><E coli><E. coli><Engineering><Enteric Bacteria><Enterobacteria><Enterobacteriaceae><Escherichia coli><Face><Flavimonas><Gene Expression><General Population><General Public><Genes><Genome><Genome engineering><Goals><Gram-Negative Bacteria><In Vitro><Infection><K pneumoniae><K. pneumoniae><Klebsiella pneumoniae><Life><Lysis><MDR organism><MDR pathogen><Mentors><Microbial Biofilms><Miscellaneous Antibiotic><Non-Polyadenylated RNA><ORFs><Open Reading Frames><Outcome><P aeruginosa><P. aeruginosa><Pathogenicity><Patients><Phages><Phase><Production><Protein Coding Region><Proteins><Pseudomonas><Pseudomonas Bacteriophages><Pseudomonas Phages><Pseudomonas aeruginosa><Pseudomonas pyocyanea><Public Health><RNA><RNA Gene Products><Reading Frames><Research Resources><Resistance><Resistance to antibiotics><Resistant to antibiotics><Resources><Ribonucleic Acid><Stretching><System><Time><Treatment Efficacy><Virus><Work><antibiotic drug resistance><antibiotic resistant><antibiotic resistant pathogen><bacteria pathogen><bacterial pathogen><bacterial virus><biofilm><design><designing><develop therapy><developmental><drug resistant><drug resistant pathogen><emerging pathogen><faces><facial><gene synthesis><innovate><innovation><innovative><interest><intervention development><intervention efficacy><multi-drug resistant organism><multi-drug resistant pathogen><multidrug resistant organism><multidrug resistant pathogen><multiple drug resistant organism><multiple drug resistant pathogen><new pathogen><novel pathogen><pathogen><pathogenic bacteria><resistance to Drug><resistant><resistant to Drug><scaffold><scaffolding><success><therapeutic efficacy><therapy development><therapy efficacy><treatment development>
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Eddy Albarran

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$126,900
FY 2026

Project Title

A Synaptic Basis for Dopamine-Driven Reinforcement Learning in Cortex

Grant Number:

1K99NS146613-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/16/2026

End Date:

12/31/2027

Why this may be worth a closer look

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Project Abstract

Project Abstract How the brain reinforces neural activity to drive learning is a fundamental question in neuroscience. Dopamine is a critical neuromodulator that shapes neural circuits during reinforcement learning by modifying synaptic connections that encode rewarding behaviors. However, the prec...

Research Terms

<2-photon><Acute><Adaptive Behaviors><Address><Anatomic Sites><Anatomic structures><Anatomy><Animals><Apical><Area><Behavior><Behavioral><Brain><Brain Nervous System><Calcium><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Collaborations><Corpus Striatum><Corpus striatum structure><DA Neuron><Dendritic Spines><Disease><Disorder><Dopamine><Dopamine neuron><Dysfunction><Encephalon><Ensure><Environment><Foundations><Functional disorder><Future><Genetic><Hydroxytyramine><Image><Imaging technology><Impairment><In Vitro><Individual><Intervention><Intracellular Communication and Signaling><Investigators><Label><Learning><Link><Maps><Measures><Mentors><Mentorship><Mesencephalon><Methodology><Mid-brain><Midbrain><Midbrain structure><Mind><Motor Cortex><Movement><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuromodulator><Neurons><Neurosciences><Opsin><Optics><Output><Paralysis Agitans><Parkinson><Parkinson Disease><Pattern><Phase><Physiopathology><Preparation><Primary Parkinsonism><Process><Psychological reinforcement><Reinforcement><Research><Research Personnel><Researchers><Rewards><Rod-Opsin><Role><Schizophrenia><Schizophrenic Disorders><Sensory><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Slice><Specificity><Spinal Column><Spine><Stimulus><Striate Body><Striatum><Structure><Synapses><Synaptic><Synaptic plasticity><Technology><Therapeutic><Time><Training><Universities><Vertebral column><Visualization><Work><adaptation behavior><adaptive behavior><addiction><addictive disorder><auditory feedback><backbone><biological signal transduction><body movement><brain behavior><brain machine interface><career><dementia praecox><dendrite spine><dopaminergic neuron><experience><experiment><experimental research><experimental study><experiments><imaging><imaging in vivo><in vivo><in vivo imaging><innovate><innovation><innovative><insight><neural><neural circuit><neural circuitry><neural control><neural regulation><neurocircuitry><neuromodulation><neuromodulatory><neuronal><neuroregulation><novel><optical><optogenetics><pathophysiology><pharmacologic><post-doctoral training><preparations><programs><schizophrenic><sensor><skills><social role><spatial and temporal><spatial temporal><spatial temporal imaging><spatial temporal mapping><spatiotemporal><spatiotemporal imaging><spatiotemporal mapping><striatal><structural imaging><synapse><synaptic circuit><synaptic circuitry><two-photon>
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Amelia Jane Hicks

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$126,735
FY 2026

Project Title

PTND PATH FORWARD study: PTND Pathologies and Trajectories of Functional Outcomes With comparison to other ADRDs

Grant Number:

1K99NS146217-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/6/2026

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY The long-term objective of this K99/R00 proposal is to provide Dr. Amelia Hicks with the expertise and skills to become an independent investigator studying the intersection of traumatic brain injury (TBI) and Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD). H...

Research Terms

<AD and related dementia><AD dementia><AD related dementia><ADRD><Acquired brain injury><Address><Adverse Late Effects><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Amentia><Area><Atherosclerosis Risk in Communities><Automobile Driving><Autopsy><Biologic Factor><Biological><Biological Factors><Biometrics><Biometry><Biostatistics><Blood><Blood Reticuloendothelial System><Body Tissues><Brain><Brain Injuries><Brain Nervous System><Brain Trauma><Categories><Chronic><Clinical><Clinical Data><Cognitive><Data><Data Set><Dementia><Development><Diagnostic><Disease><Disorder><Encephalon><Environment><Environmental Factor><Environmental Risk Factor><Exhibits><Faculty><Failure><Family><Funding><Goals><Impairment><Increase lifespan><Injury><Intervention><Investigators><Knowledge><Knowledge acquisition><Late Effects><Lead><Logistic Regressions><Long-term prospective studies><Mann-Whitney U Test><Mentors><Modeling><Motor><NIH><National Institutes of Health><Nerve Degeneration><Neuron Degeneration><Neuropsychologies><Neuropsychology><Outcome><Pathologic><Pathology><Patients><Pattern><Pb element><Persons><Phase><Phenotype><Primary Senile Degenerative Dementia><Prognosis><Proteins><Proteomics><Research><Research Activity><Research Personnel><Research Resources><Researchers><Resources><Risk><Survivors><Testing><Tissues><Training><Training Activity><Traumatic Brain Injury><United States National Institutes of Health><Work><accurate diagnosis><ages><biologic><blood-based biomarker><blood-based marker><boost longevity><brain damage><brain tissue><brain-injured><career><career development><clinical diagnosis><clinical phenotype><clinical prognosis><cohort><comparator group><comparison group><developmental><driving><elongating the lifespan><enhance longevity><environmental risk><experience><extend life span><extend lifespan><extend longevity><foster longevity><functional outcomes><heavy metal Pb><heavy metal lead><improve lifespan><improve longevity><improved><in vivo><injuries><lifespan extension><longitudinal, prospective study><medical college><medical schools><member><necropsy><neural degeneration><neurobehavioral><neurodegeneration><neurodegenerative><neurological degeneration><neuronal degeneration><neuropathologic><neuropathological><neuropathology><neuropsychologic><novel><personalized health intervention><personalized intervention><postmortem><precision interventions><primary degenerative dementia><programs><prolong lifespan><prolong longevity><promote lifespan><promote longevity><protein biomarkers><protein markers><resilience><resilient><school of medicine><senile dementia of the Alzheimer type><skills><support longevity><training module><traumatic brain damage>
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Yongkai Liu

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$125,685
FY 2026

Project Title

Fused Imaging and Large Language Foundational Model for 90-day Stroke Outcome Prediction

Grant Number:

5K99NS140547-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

The advent of endovascular therapy (EVT) has revolutionized the treatment of acute ischemic strokes (AIS) caused by large vessel occlusions, affecting up to 700,000 Americans annually. However, despite this significant advance, the current approach to EVT patient selection, primarily based on neuroi...

Research Terms

<AI based><AI language models><AI system><Achievement><Achievement Attainment><Acute><Address><Affect><Age><American><Apoplexy><Artificial Intelligence><Award><Blood Pressure><Body Tissues><Brain Vascular Accident><Caring><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Clinical><Clinical Data><Clinical Research><Clinical Study><Clinical Trials><Collaborations><Computer Reasoning><Computer Software Tools><ConvNet><Data><Data Set><Decision Making><Development><Development Plans><Disease><Disorder><Dysfunction><Effectiveness><Eligibility><Eligibility Determination><Engineering><Ensure><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Expert Systems><Fostering><Functional disorder><Future><General Radiology><Goals><Health><Image><Influentials><Intelligent systems><Intervention><Investigators><Investments><Ischemic Stroke><Language><Learning><Machine Intelligence><Machine Learning><Medical><Medical History><Mentorship><Methodology><Methods><Modeling><NIH><National Institutes of Health><Network-based><Neurology><Outcome><Patient Care><Patient Care Delivery><Patient Selection><Patient Triage><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Performance><Personal Medical History><Personal Medical History Epidemiology><Personalized medical approach><Phase><Physicians><Physiopathology><Prediction of Response to Therapy><Predisposition><Process><Protocol Screening><Provider><Racial Group><Radiology><Radiology Specialty><Registries><Research><Research Personnel><Researchers><Sampling><Scientific Inquiry><Software Tools><Stroke><Structure><Susceptibility><Symptoms><Testing><Text><Tissues><Training><Transformer language model><Treatment Efficacy><Triage><Uncertainty><United States National Institutes of Health><University Hospitals><Variant><Variation><Work><ages><artificial intelligence based><artificial intelligence language models><brain attack><care for patients><care of patients><career development><caring for patients><cerebral vascular accident><cerebrovascular accident><clinical applicability><clinical application><cohort><computer science><convolutional network><convolutional neural nets><convolutional neural network><data registry><deep learning><deep learning based model><deep learning method><deep learning model><deep learning strategy><design><designing><developmental><doubt><empowerment><ethnic subgroup><ethnicity group><experience><follow up imaging><functional outcomes><holistic approach><hospital re-admission><hospital readmission><imaging><improved><individualized approach><innovate><innovation><innovative><insight><intervention efficacy><large language model><large scale language model><life-style factor><lifestyle factors><machine based learning><machine learning based method><machine learning method><machine learning methodologies><massive scale language models><model generalizability><multi-modal data><multi-modal datasets><multi-modality><multilayer perceptron><multimodal data><multimodal datasets><multimodality><neglect><neural imaging><neuro-imaging><neuroimaging><neurological imaging><outcome prediction><pathophysiology><patient centered><patient oriented><patient oriented outcomes><personalized approach><precision approach><predict clinical outcome><predict therapeutic response><predict therapy response><prospective><racial population><racial subgroup><re-admission><re-hospitalization><readmission><rehospitalization><sex><skills><software toolkit><stroke outcome><stroke patient><stroke therapy><stroke treatment><stroked><strokes><structured data><symptomatology><synergism><tailored approach><therapeutic efficacy><therapy efficacy><therapy prediction><tool><treating stroke><treatment prediction><treatment response prediction><treatment strategy>
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Andre Sanchez

HARVARD UNIVERSITY, CAMBRIDGE, MA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$125,000
FY 2026

Project Title

Enantioselective Hydrochlorination of Alkenes enabled by Cooperative Catalysis and Enantioconvergent Dynamic Kinetic Resolution of Quaternary Stereocenters

Grant Number:

1K99GM163037-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract The hydrochlorination of alkenes is a central reaction in introductory organic chemistry, illustrating fundamental concepts in organic mechanism and reactivity. Despite its pedagogical ubiquity, and the growing importance of alkyl chlorides in synthesis and drug discovery, e...

Research Terms

<Acids><Address><Alkenes><Area><Biological><Carbon><Catalysis><Cats><Cats Mammals><Chemicals><Chlorides><Complex><Coupling><Derivation><Derivation procedure><Development><Development Plans><Domestic Cats><Educational process of instructing><Evaluation><Exhibits><Feline Species><Felis catus><Felis domestica><Felis domesticus><Felis sylvestris catus><Ga element><Gallium><Goals><H-bond><Health><Human><Hydrogen Bonding><Improve Access><Investigation><Kinetics><Medicinal Chemistry><Mentors><Metals><Modern Man><Olefins><Organic Chemistry><Organic Synthesis><Pharmaceutic Chemistry><Pharmaceutical Chemistry><Postdoc><Postdoctoral Fellow><Property><Reaction><Reagent><Research><Research Associate><Resolution><Source><Stereoisomer><System><Teaching><Technology><Therapeutic><Transition Elements><Variant><Variation><biologic><biological systems><career><career development><career fair><career networking><catalyst><cats><chiral molecule><computational studies><computer studies><conference><convention><design><designing><developmental><drug discovery><graduate student><high school><improved><innovate><innovation><innovative><insight><metal complex><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><post-doc><post-doctoral><post-doctoral trainee><professional networking><research associates><resolutions><small molecule><speed networking><summit><symposia><symposium><transition metal><undergrad><undergraduate><undergraduate student>
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Nho Cong Luong

EMORY UNIVERSITY, ATLANTA, GA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$125,000
FY 2026

Project Title

Role of Protein N-Myristoylation in Driving DNA Damage Response

Grant Number:

5K99GM157498-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT The DNA damage response (DDR) is crucial for maintaining genome stability, with its dysregulation implicated in various diseases. Post-translational modifications (PTMs) orchestrate DDR, influencing vital signaling pathways for genomic stability. N-myristoylation, catalyzed ...

Research Terms

<AD dementia><Abscission><Acetylation><Address><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Assay><Atlases><Automobile Driving><Award><Bioassay><Biological Assay><Biological Function><Biological Process><Cancers><Carbon><Cell Body><Cells><Communities><DNA Damage><DNA Damage Repair><DNA Injury><DNA Repair><Data><Development><Disease><Disorder><Double Strand Break Repair><Dysfunction><EC 2.3.1.97><Epilepsy><Epileptic Seizures><Epileptics><Evaluation><Excision><Extirpation><Fostering><Functional disorder><G22P1><G22P1 gene><Genome Instability><Genome Stability><Genomic DNA><Genomic Instability><Genomic Stability><Genomics><Glycylpeptide N-Tetradecanoyltransferase 2><Goals><HCT 116 Cells><HCT- 116><HCT-116><HCT116><HCT116 Cells><HDAC><HDAC Proteins><Histone Deacetylase><Infection><Investigation><Knowledge><Ku70><Label><Laboratories><Link><Malignant Neoplasms><Malignant Tumor><Mediating><Medical><Mentors><Metabolic><Methylation><Modification><Myristic Acylation Site><Myristoylation Site><N-Myristoylation><N-Myristoyltransferase 2><NMT2><NMT2 gene><Pathway interactions><Phase><Phosphorylation><Physiopathology><Position><Positioning Attribute><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Precision therapeutics><Primary Senile Degenerative Dementia><Principal Investigator><Protein Dynamics><Protein Modification><Protein Phosphorylation><Proteins><Proteomics><Regulation><Removal><Research><Research Proposals><Role><Running><Science><Seizure Disorder><Signal Pathway><Silent Mating Type Information Regulator 2-like Proteins><Sir2-like Proteins><Sirtuins><Surgical Removal><TCGA><TLAA><Technical Expertise><Techniques><The Cancer Genome Atlas><Therapeutic><Therapeutic Intervention><Training><Transferase><Transferase Gene><Treatment Efficacy><Ubiquitilation><Ubiquitination><Ubiquitinoylation><Unscheduled DNA Synthesis><Work><acyl group><candidate identification><develop therapy><developmental><driving><epilepsia><epileptogenic><expectation><experiment><experimental research><experimental study><experiments><frontier><gDNA><insight><intervention development><intervention efficacy><intervention therapy><malignancy><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><myristoylation><neoplasm/cancer><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathophysiology><pathway><precision therapies><precision treatment><primary degenerative dementia><protein function><resection><response><screening><screenings><senile dementia of the Alzheimer type><skills><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><technical skills><therapeutic efficacy><therapy development><therapy efficacy><translational opportunities><translational potential><treatment development><ubiquination><ubiquitin conjugation><validation studies>
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Jonnathan Singh Alvarado

BETH ISRAEL DEACONESS MEDICAL CENTER, BOSTON, MA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$124,713
FY 2026

Project Title

Identification of a Circuit Basis for Neuropathic Pain in the Parabrachial Nucleus

Grant Number:

5K99NS140561-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary / Abstract The parabrachial nucleus (PBN) serves as a crucial nexus where nociceptive sensory signals from the spinal cord are transformed into the unpleasant components of pain. Persistent forms of pain such as neuropathic pain result in hyperexcitation of a subset of PBN neurons, w...

Research Terms

<2-photon><3-D Imaging><3D imaging><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><Absence of pain sensation><Absence of sensibility to pain><Advisory Committees><Affect><Agonist><Aminalon><Aminalone><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Analgesia Tests><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Arousal><Aversive Stimulus><Axon><Behavior><Brain><Brain Nervous System><Brain Stem><Brain region><Brainstem><Breathing><Cell Communication and Signaling><Cell Signaling><Committee Members><Cyclic Somatostatin><Data Analyses><Data Analysis><Development><Disease><Disorder><Drugs><EASI><Encephalon><Epithelial Cell Aggregation and Separation><Feels no pain><Financial Hardship><Future><GABA><Gene Transcription><Generations><Genetic><Genetic Markers><Genetic Transcription><Goals><Growth Hormone Inhibiting Factors><Growth Hormone-Inhibiting Hormone><Image><In Situ Hybridization><Individual><Infusion><Infusion procedures><Injury><Intervention><Intracellular Communication and Signaling><Investigators><Itching><Label><Laboratories><Link><Lithium Chloride><Maintenance><Malaise><Maps><Measures><Mechanics><Medication><Medulla Spinalis><Mentors><Mentorship><Messenger RNA><Metabolic><Methods><Modeling><Molecular><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neuropeptides><No sensitivity to pain><Nociception><Nociception Tests><Operative Procedures><Operative Surgical Procedures><Opsin><Pain><Pain Assessment><Pain Control><Pain Disorder><Pain Measurement><Pain Therapy><Pain Threshold><Pain Tolerance Level><Pain management><Pain measure><Painful><Pharmaceutical Preparations><Physiologic><Physiological><Preparation><Process><Pruritic Disorder><Pruritis><Pruritus><RNA Expression><Research><Research Personnel><Researchers><Respiratory Aspiration><Respiratory Inspiration><Rod-Opsin><Running><SRIH><SRIH Receptors><SRIH-14><Satiation><Sensory><Signal Transduction><Signal Transduction Systems><Signaling><Societies><Somatostatin><Somatostatin Receptor><Somatostatin-14><Somatotropin Release Inhibiting Factors><Somatotropin Release Inhibiting Hormone Receptors><Somatotropin Release-Inhibiting Hormone><Spinal Cord><Stimulus><Surgical><Surgical Interventions><Surgical Procedure><Task Forces><Techniques><Temperature><Testing><Therapeutic><Three-Dimensional Imaging><Time><Training><Transcription><Transgenic Mice><Visceral><advisory team><amygdaloid nuclear complex><analgesia><biological signal transduction><career development><cell type><central pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><cortical pain><data interpretation><design><designing><developmental><drug/agent><economic hardship><economic strain><experiment><experimental research><experimental study><experiments><financial adversity><financial burden><financial distress><financial insecurity><financial instability><financial strain><financial stress><financial worry><gamma-Aminobutyric Acid><gene biomarker><gene expression biomarker><gene marker><gene signature biomarker><genetic biomarker><growth hormone release inhibiting factor><imaging><imaging in vivo><in situ Hybridization Genetics><in situ Hybridization Staining Method><in vivo><in vivo imaging><infusions><inhibit pain><injuries><innovate><innovation><innovative><inspiration><itch sensation><mRNA><mechanic><mechanical><meeting><meetings><nerve injury><neural injury><neuronal><neuropathic pain><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><nociceptive><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><optical sensor><optogenetics><pain assay><pain inhibition><pain intervention><pain killer><pain medication><pain perception><pain processing><pain reliever><pain tolerance><pain treatment><painful neuropathy><painkiller><parabrachial nucleus><preparations><prevent><preventing><programs><recruit><redshift><response><satiety><skills><social><spared nerve><surgery><therapeutic target><tool><transcriptomics><treat chronic pain><two-photon><γ-Aminobutyric Acid>
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Yize Li

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$113,372
FY 2026

Project Title

SERPINE family genes in rhabdoid tumorigenesis

Grant Number:

5K99CA297000-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Malignant tumors characterized by rhabdoid features often display highly aggressive biology, frequently resulting in fatal outcomes, even when these features are localized to small areas within the tumors. Despite their relatively low occurrence, rhabdoid features have been ...

Research Terms

<Address><Affect><Area><Award><Biology><Biopsy Sample><Biopsy Specimen><Cancer Patient><Cancers><Cell Culture Techniques><Clear Cell><Clear cell renal cell carcinoma><Clinical><Computer Analysis><Data><Data Science><Data Set><Decision Making><Development><Diagnosis><Diagnostic Method><Diagnostic Procedure><Diagnostic Technique><Down-Regulation><Exhibits><Face><Fatal Outcome><Gene Family><Genetic><Goals><Grawitz Tumor><Heterogeneity><Histopathology><Hypernephroid Carcinoma><Hypernephroma><Image><In Situ><Institution><Investigation><Investigators><Knowledge><Link><Malignant Neoplasms><Malignant Tumor><Mentors><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Molecular><Molecular Fingerprinting><Molecular Profiling><Multiomic Data><Neoplasm Metastasis><Nephroid Carcinoma><Oncogenesis><Pathway interactions><Phase><Phenotype><Prediction of Response to Therapy><Primary Neoplasm><Primary Tumor><Procedures><Prognosis><Protocol><Protocols documentation><Publishing><Renal Adenocarcinoma><Renal Cell Adenocarcinoma><Renal Cell Cancer><Renal Cell Carcinoma><Reporting><Research><Research Personnel><Researchers><Role><SERPINE1><SERPINE1 gene><Secondary Neoplasm><Secondary Tumor><Selection for Treatments><Stratification><TCGA><Technology><The Cancer Genome Atlas><Therapeutic><Training><Training Programs><Tumor Cell><Upregulation><Variant><Variation><Work><accurate diagnosis><cancer metastasis><cancer type><career><ccRCC><cell culture><cell cultures><cohort><computational analyses><computational analysis><computer analyses><developmental><differential expression><differentially expressed><effective therapy><effective treatment><experience><experiment><experimental research><experimental study><experiments><faces><facial><imaging><insight><kidney adenocarcinoma><malignancy><molecular profile><molecular signature><multiomics><multiple omic data><multiple omics><neoplasm/cancer><neoplastic cell><panomics><pathway><potential biological marker><potential biomarker><predict therapeutic response><predict therapy response><programs><response to therapy><response to treatment><selection of treatment><skills><social role><success><tenure process><tenure track><therapeutic response><therapeutic target><therapy prediction><therapy response><therapy selection><tool><transcriptional differences><treatment prediction><treatment response><treatment response prediction><treatment responsiveness><treatment selection><treatment strategy><tumor><tumor cell metastasis><tumorigenesis>
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Golnaz Morad

UNIVERSITY OF TX MD ANDERSON CAN CTR, HOUSTON, TX

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$112,026
FY 2026

Project Title

The role of oral microbiota in metastatic brain tumors

Grant Number:

5K99CA296780-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/10/2025

End Date:

2/28/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Brain metastasis is a major clinical challenge associated with high morbidity and mortality. Growing evidence suggests a critical role for the immune system in the pathophysiology of brain metastasis. Our group and others have demonstrated that microbiota, i.e. the assembly of micro...

Research Terms

<21+ years old><Adult><Adult Human><Advisory Committees><Anti-Bacterial Response><Antibacterial Response><Award><Bacterial Translocation><Biological Response Modifiers><Biomodulators><Brain><Brain Metastasis><Brain Neoplasia><Brain Neoplasms><Brain Nervous System><Brain Tumors><Buccal Cavity><Buccal Cavity Head and Neck><Cancer Center><Cancers><Cavitas Oris><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Characteristics><Clinical><Clinical Research><Clinical Study><Development><Development Plans><Development and Research><Diagnostic><Dimensions><Disease><Disease Outcome><Disorder><Dysfunction><Encephalon><Environment><Exhibits><Foundations><Functional disorder><Goals><Gum Disease><Hortega cell><Human Figure><Human body><Immune><Immune Mediators><Immune Mediators/Modulators><Immune infiltrates><Immune response><Immune system><Immunes><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Infiltration><Innate Immunity><Intracellular Communication and Signaling><Investigation><Knowledge><MDACC><Malignant Melanoma><Malignant Neoplasms><Malignant Tumor><Melanoma><Mentors><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Neoplasm to the Brain><Metastatic Tumor><Metastatic Tumor to the Brain><Metastatic malignant neoplasm to brain><Methods><Mice><Mice Mammals><Microbe><Microglia><Monitor><Morbidity><Mouth><Mouth microbiome><Murine><Mus><Native Immunity><Natural Immunity><Neoplasm Metastasis><Non-Specific Immunity><Nonspecific Immunity><Oral><Oral cavity><Outcome><Parodontosis><Patients><Periodontal Diseases><Phagocytes><Phagocytic Cell><Phase><Physiopathology><Play><Postdoc><Postdoctoral Fellow><Preventative intervention><Preventive><Primary Neoplasm><Primary Tumor><R & D><R&D><Radio><Research><Research Associate><Role><Route><Sampling><Secondary Neoplasm><Secondary Tumor><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Source><Supervision><Task Forces><Therapeutic><Therapeutic Intervention><Time><Training><Training Activity><Transcription Alteration><Translational Research><Translational Science><Tumor Cell><Tumor Immunity><University of Texas M D Anderson Cancer Center><University of Texas MD Anderson Cancer Center><Visualization><adulthood><advisory team><amebocyte><anti-cancer research><anti-tumor effect><anti-tumor immune response><anti-tumor immunity><antitumor effect><antitumor immunity><behavior change><biological signal transduction><brain micrometastasis><brain tissue><cancer immunity><cancer immunology><cancer metastasis><cancer microenvironment><cancer research><career><career development><chemotherapy><clinical care><cohort><community microbes><cost effective><developmental><digital><dysbacteriosis><dysbiosis><dysbiotic><gitter cell><host response><immune cell infiltrate><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive response><improved><improved outcome><inflammatory environment><inflammatory milieu><insight><intervention for prevention><intervention therapy><malignancy><melanoma cancer model><melanoma model><melanoma tumor model><mesoglia><microbe community><microbial community><microbial consortia><microbial flora><microbial imbalance><microbial signature><microbiome><microbiota><microflora><microglial cell><microgliocyte><microorganism community><migration><mortality><mouse model><multispecies consortia><murine model><neoplasm immunology><neoplasm/cancer><neoplastic cell><neural inflammation><neuroinflammation><neuroinflammatory><new diagnostics><next generation diagnostics><novel><novel diagnostics><oral bacteria><oral flora><oral microbial community><oral microbiome><oral microbiota><oral microflora><pathophysiology><periodontal disorder><periodontium disease><periodontium disorder><perivascular glial cell><polymicrobial community><post-doc><post-doctoral><post-doctoral trainee><prevention intervention><preventional intervention strategy><preventive intervention><prospective><research and development><research associates><response><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><training module><translation research><translational investigation><tumor><tumor cell metastasis><tumor immunology><tumor microbiome><tumor microenvironment><tumor-associated microbiome><tumors in the brain>
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Kelly A. Romano

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$99,413
FY 2026

Project Title

Targeting transdiagnostic self-regulatory factors and eating disorder pathology among adults with binge-spectrum eating disorders: A mHealth interoceptive exposure intervention

Grant Number:

5K99MH138634-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Binge-spectrum eating disorders (BSED; bulimia nervosa, binge eating disorder) are associated with a high risk of mortality and debilitating health outcomes. Yet, over half of people who receive empirically- supported BSED treatments remain symptomatic and relapse is common...

Research Terms

<21+ years old><Active Follow-up><Adult><Adult Human><After Care><After-Treatment><Aftercare><Anxiety Disorders><Autonomic nervous system><Binge Eating><Binge eating disorder><Biofeedback><Brain><Brain Nervous System><Breathing><Bulimia><Bulimia Nervosa><Caring><Data><Diagnostic><Eating Disorders><Ecological momentary assessment><Encephalon><Esthesia><Exposure to><Fear><Fright><Goals><Health><Holter Electrocardiography><Holter Monitoring><Holtmon><Hunger><Institution><Interoception><Intervention><Just-in-Time Adaptive Intervention><Learning><Link><Maintenance><Maps><Mental Health><Mental Hygiene><Mentors><Methods><Morbidity><NIMH><National Institute of Mental Health><Nervous System Physiology><Neurobiology><Neurologic function><Neurological function><Outcome><Participant><Pathology><Patient Self-Report><Persons><Prevalence><Prevention><Process><Psychological Health><Psychopathology><Randomized><Relapse><Reporting><Research><Research Institute><Research Resources><Resources><Respiratory Aspiration><Respiratory Inspiration><Satiation><Scanning><Self-Report><Sensation><Sensation Disorders><Sensory><Symptoms><Testing><Time><Training><Translating><Treatment outcome><Work><Wrist><abnormal psychology><acceptability and feasibility><active followup><adulthood><arm><biobehavior><biobehavioral><bodily sensation><bulimic><career><co-morbid><co-morbidity><comorbidity><compulsive eating><compulsive feeding><compulsive overeating><death risk><design><designing><effective intervention><experience><feasibility testing><follow up><follow-up><followed up><followup><heart rate variability><high risk><improved><innovate><innovation><innovative><inspiration><intervention mapping><m-Health><mHealth><mHealth therapeutic><mHealth therapy><mHealth treatment><mhealth interventions><mobile health><mobile health intervention><mobile health therapeutic><mobile health therapy><mobile health treatment><mortality><mortality risk><multiphase optimization strategy><nervous system function><neurobiological><physical conditioning><physical health><post treatment><programs><purge><purges><purging><randomisation><randomization><randomly assigned><satiety><sensor><skills><smart watch><smartwatch><statistics><symptom treatment><symptomatic treatment><theories><translational impact><treat symptom><treatment adherence><treatment and outcome><treatment compliance>
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Tadashi Takeuchi

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$91,500
FY 2026

Project Title

Harnessing Metabolic Machinery of Gut Bacteria for Metabolic Dysfunction-Associated Steatohepatitis

Grant Number:

1K99DK146142-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/6/2026

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Metabolic dysfunction-associated steatohepatitis (MASH) is a growing public health concern in industrialized nations, with an estimated cost of $1.66 trillion in the U.S. by 2039. Despite its prevalence, therapeutic strategies remain limited due to an incomplete understandin...

Research Terms

<Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antiinflammatory Effect><Award><Bacteria><Bacterial Genes><Biological><Biology><Biomedical Research><Bionomics><C butyricum><C. butyricum><Cell Body><Cells><Clostridium butyricum><Collection><Complex><Data Bases><Databases><Developed Countries><Diet><Dietary Polysaccharide><Ecology><Engraftment><Equipment><Experimental Models><Fibrosis><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Functional Metagenomics><GI colonization><GI microbiome><GI microbiota><Gastrointestinal microbiota><Generalized Growth><Genes><Genome><Glycans><Goals><Growth><Health><Health Promotion><Hepatic Disorder><Human><Hydroxy Acids><Immune><Immunes><Individual><Indoles><Industrialization><Industrialized Countries><Industrialized Nations><Inflammation><Inflammatory><Institution><Interdisciplinary Research><Interdisciplinary Study><Investigators><Liver><Liver diseases><Macrophage><Maps><Mentors><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic dysfunction><Metagenomics><Methods><Mice><Mice Mammals><Microbiology><Microbiomics><Modeling><Modern Man><Molecular><Multidisciplinary Collaboration><Multidisciplinary Research><Murine><Mus><Mφ><NK T cell><NKT cell><Natural Killer T cell><Nutrient><Oral Administration><Oral Drug Administration><Pathogenesis><Plants><Play><Polysaccharides><Population><Portal Vein><Portal vein structure><Prevalence><Process><Production><Public Health><Research><Research Personnel><Research Resources><Researchers><Resolution><Resources><Role><Salutogenesis><Short-Chain Fatty Acids><Steatohepatitis><Tanzania><Therapeutic><Therapeutic Effect><Thesaurismosis><Tissue Growth><Training><Universities><Volatile Fatty Acids><anti-inflammatory effect><bacteria in the gut><bacteria metabolism><bacterial metabolism><biologic><branched chain fatty acid><career development><combat><cost estimate><cost estimation><cytokine><data base><developed country><developed nation><developed nations><dietary><diets><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal sample><fecal transplant><fecal transplantation><flow cytophotometry><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal tract colonization><gut bacteria><gut colonization><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><hepatic body system><hepatic disease><hepatic inflammation><hepatic organ system><hepatopathy><hydroxyacid><improved><inflamed liver><insight><intestinal biome><intestinal colonization><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><intraoral drug delivery><liver disorder><liver inflammation><metabolism disorder><metabolism measurement><metabolomics><metabonomics><microbial consortia><microbial flora><microbiome><microbiome intervention><microbiome research><microbiome science><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microflora><mouse model><multispecies consortia><murine model><natural killer T lymphocyte><new approaches><novel approaches><novel strategies><novel strategy><ontogeny><programs><promoting health><rational design><resolutions><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skill acquisition><skill development><skills><social role><stool sample><stool specimen><translation strategy><translational approach><translational strategy>
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Lakshmi Gopalakrishnan

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$49,668
FY 2026

Project Title

Adaptation and pilot testing of a couples-based intervention to prevent perinatal depression in rural India

Grant Number:

3K99HD114849-02S2

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2024

End Date:

7/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary Nearly one in four women in India experience perinatal depression, which occurs during pregnancy or the postpartum period. Preventing perinatal depression (PND) is important for the health of the mother and child as untreated PND is associated with long-lasting consequences such as a...

Research Terms

<0-11 years old><Active Follow-up><Address><Affect><Asia><Award><Career Mobility><Child><Child Health><Child Rearing><Child Youth><Children (0-21)><Couples><Data Analyses><Data Analysis><Decision Making><Economic Income><Economical Income><Evidence based intervention><Gestation><Goals><Husband><Impairment><Income><India><Inequity><Intervention><Investigators><Knowledge><Low income><Marital Relationships><Marriage><Maternal Health><Maternal and Child Health><Mental Depression><Mentors><Outcome><Parenting><Parenting behavior><Pathway interactions><Phase><Phase Transition><Postpartum Period><Pregnancy><Pregnant Women><Preventative intervention><Preventive><Primiparity><Randomized, Controlled Trials><Research><Research Personnel><Researchers><Risk Factors><Rural><Sampling><Social support><Testing><Time><Training><Woman><active followup><bear children><bearing children><career><career advancement><career transition><child bearing><childbearing><childrearing><data interpretation><depression><develop therapy><expectant mother><expectant women><expecting mother><expecting women><experience><follow up><follow-up><followed up><followup><health of the mother><implementation science><improved><incomes><individuals who are pregnant><intervention development><intervention for prevention><intervention refinement><kids><multidisciplinary><neonatal health><newborn health><offspring><pathway><people who are pregnant><perinatal depression><perinatal mental health><perinatal period><perinatal phase><peripartum depression><pilot test><post-partum><preference><pregnant><pregnant females><pregnant mothers><pregnant people><pregnant populations><prevent><preventing><prevention intervention><preventional intervention strategy><preventive intervention><primipara><primiparous><randomized control trial><shared decision making><skills><social support network><suicidal risk><suicide risk><therapy development><those who are pregnant><treatment development><women who are pregnant><youngster>
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Samantha Schildroth

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Exploratory lead · 38/100
Training-friendly
Recent
Career award
$121,134
FY 2026

Project Title

A Prospective Study of Per-and Polyfluoroalkyl Substance (PFAS) Mixtures and Pregnancy Outcomes among Black Women

Grant Number:

5K99ES036288-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/15/2024

End Date:

3/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Per- and polyfluoroalkyl substances (PFAS) are known endocrine disrupting chemicals (EDCs), and exposure to PFAS has been associated with adverse pregnancy outcomes, including spontaneous abortion (SAB), preterm birth (PTB), and small for gestational age (SGA) births. However, less is known about 1)...

Research Terms

<Accounting><Active Follow-up><Address><Adverse effects><Affect><Amino Acids><Animals><Award><Biological><Biological Markers><Birth><Blood Plasma><Caucasian Females><Caucasian Women><Causality><Chemicals><Child Health><Chronologic Fetal Maturity><Clinic Visits><Data><Endocrine><Endocrine Disrupter><Endocrine Disrupting Chemicals><Endocrine Disruptors><Endocrine disrupting agent><Endocrine disruption><Endocrine system><Endocrine/Metabolic Organ System><Enrollment><Environment><Environmental Exposure><Epidemiological data><Epidemiology><Epidemiology data><Etiology><Exposure to><Fetal Age><Fibroid><Fibroid Neoplasm><Fibroid Tumor><Fibromyoma><Funding><Future><Gestation><Gestational Age><Goals><Health Care Costs><Health Care Systems><Health Costs><Hormonal><Hormonal System><Individual><Industrial Product><Infant><Investigators><Joints><Knowledge><Leiomyomatous Neoplasm><Leiomyomatous Tumor><Life Style><Lifestyle><Literature><Measures><Mediating><Mediation><Mediator><Metabolic Pathway><Metabolic/Endocrine Body System><Methods><Miscarriage><NIEHS><National Institute of Environmental Health Sciences><Negotiating><Negotiation><Outcome><PFAS><Participant><Parturition><Pathway interactions><Perinatal><Perinatal Epidemiology><Peripartum><Phase><Plasma><Plasma Serum><Play><Poly-fluoroalkyl substances><Pregnancy><Pregnancy Outcome><Premature Birth><Prematurely delivering><Preterm Birth><Prospective Studies><Prospective cohort><Prospective, cohort study><Psychosocial Factor><Questionnaires><Research><Research Personnel><Researchers><Reticuloendothelial System, Serum, Plasma><Risk Factors><Role><Sample Size><Sampling><Small for Gestational Age Infant><Societies><Spontaneous abortion><Structure><Toxic effect><Toxicities><Training><Visit><White Females><White Women><Woman><Women's study><Work><active followup><adverse pregnancy outcome><aminoacid><before conception><bio-markers><biologic><biologic marker><biomarker><black female><black women><career><causation><childbearing age><cohort><consumer product><disease causation><ecological toxicology><endocrine disrupting><endocrine disrupting compound><endocrine gland/system><enroll><environmental chemical><environmental toxicology><epidemiologic><epidemiologic data><epidemiological><experience><exposed human population><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fat metabolism><female study><fertile age><follow up><follow-up><followed up><followup><hormone metabolism><human exposure><lipid metabolism><metabolism measurement><metabolomics><metabonomics><novel><pathway><perceived stress><perception of stress><perfluorinated alkyl substances><perfluoroalkyl substances><perfluoroalkylated substances><polyfluorinated alkyl substances><polyfluoroalkyl substances><postpartum health><preconception><premature childbirth><premature delivery><preterm delivery><prior to conception><prospective><prospective research study><prospective survey><psychosocial variables><public health intervention><recruit><reproductive><reproductive age><reproductive years><self-reported stress><small for gestational age><social role><stress perception><study among females><study among women><study in females><study in women><study on females><study on women><study within women><substance use><substance using><toxicant>
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PAMELA GALLO

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Exploratory lead · 34/100
Training-friendly
Active award
$76,300
FY 2026

Project Title

Structural determination of TrkB assembly and activation

Grant Number:

1F32GM163382-01

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY The proposed project encompasses a comprehensive research plan to support the development of my career as an independent scientist focused on investigating the assembly and conformational dynamics of neuronal integral membrane receptors, and how structure is related to receptor activ...

Research Terms

<Adopted><Affective Disorders><Assay><Award><Binding><Binding Site Domain><Bioassay><Biochemical><Biological><Biological Assay><Biophysical Process><Biophysics><Brain><Brain Nervous System><Cancers><Cell Body><Cell Communication and Signaling><Cell Membrane Permeability><Cell Signaling><Cell surface><Cells><Cellular Membrane><Complement><Complement Proteins><Complex><Cryo-electron Microscopy><Cryoelectron Microscopy><Degenerative Neurologic Disorders><Development><Dimerization><Disease><Disorder><EGF Receptor><EGFR><ERBB Protein><Electron Cryomicroscopy><Electron Microscopy><Encephalon><Environment><Epidermal Growth Factor Receptor><Epidermal Growth Factor Receptor Kinase><Epidermal Growth Factor Receptor Protein-Tyrosine Kinase><Epidermal Growth Factor-Urogastrone Receptors><FRET><Fluorescence><Fluorescence Resonance Energy Transfer><Fluoxetin><Fluoxetine><Foundations><Förster Resonance Energy Transfer><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><Goals><HER1><In Vitro><Institution><Integral Membrane Protein><Intracellular Communication and Signaling><Intrinsic Membrane Protein><Investigators><Isoforms><Ketamine><Kinases><Knowledge><Length><Ligand Binding><Ligand Binding Domain><Ligands><Literature><Malignant Neoplasms><Malignant Tumor><Measurement><Membrane><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Mentors><Methods><Modeling><Molecular><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Mood Disorders><NGF Receptors><NT-4><Negative Staining><Nerve Cells><Nerve Degeneration><Nerve Growth Factor Receptors><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurodevelopmental Disorder><Neurologic Degenerative Conditions><Neurological Development Disorder><Neuron Degeneration><Neurons><Neurotrophic Factor Receptor><Neurotrophin Receptors><Oncology><Oncology Cancer><Optics><PTK Receptors><Pathway interactions><Pharmacology><Phosphotransferase Gene><Phosphotransferases><Photobleaching><Physiologic><Physiological><Play><Population><Process><Protein Dimerization><Protein Isoforms><Proteins><Prozac><Publications><Receptor Activation><Receptor Protein><Receptor Protein-Tyrosine Kinases><Receptor Tyrosine Kinase Gene><Regulation><Reporting><Research><Research Design><Research Personnel><Researchers><Resolution><Role><Scientific Publication><Scientist><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Stimulus><Structural Models><Structure><Study Type><Surface Proteins><Synaptic plasticity><TGF-alpha Receptor><Techniques><Time><Training><Transforming Growth Factor alpha Receptor><Transmembrane Protein><Transmembrane Protein Gene><Transmembrane Receptor Protein Tyrosine Kinase><Transphosphorylases><Tropomyosin><Tyrosine Kinase Linked Receptors><Tyrosine Kinase Receptors><Urogastrone Receptor><Work><anti-depressant agent><anti-depressant drugs><anti-depressants><anti-depressive agents><biologic><biological signal transduction><biophysical foundation><biophysical mechanism><biophysical principles><biophysical sciences><c-erbB-1><c-erbB-1 Protein><career><complementation><conformation><conformational><conformational state><conformationally><conformations><cryo-EM><cryoEM><cryogenic electron microscopy><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><dimer><drug development><erbB-1><erbB-1 Proto-Oncogene Protein><erbBl><experience><extracellular><fluorophore><functional outcomes><improved><in vivo Model><insight><interest><mGluR2><malignancy><medical college><medical schools><meeting><meetings><member><membrane permeability><membrane structure><metabotropic glutamate receptor 2><monomer><mutant><neoplasm/cancer><neural control><neural degeneration><neural regulation><neurodegeneration><neurodegenerative><neurodegenerative illness><neurodevelopmental disease><neurological degeneration><neuromodulation><neuromodulatory><neuronal><neuronal degeneration><neuronal growth><neuropsychiatric disease><neuropsychiatric disorder><neuroregulation><neurotrophic factor><neurotrophin><neurotrophin 4><neurotropic><neutrophin><novel><optical><p75><p75 transcription factor><pathway><pharmacologic><polypeptide><prevent><preventing><programs><proto-oncogene protein c-erbB-1><receptor><receptor function><resolutions><response><school of medicine><single molecule><single-molecule FRET><single-molecule fluorescence resonance energy transfer><smFRET><social role><stoichiometry><structural determinants><structural factors><study design><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic agent development><therapeutic development><therapeutic target><therapeutically effective><tool><trafficking><transcriptional coactivator p75><tropomyosin kinase>
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Morgan E. Smith

UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR, OKLAHOMA CITY, OK

Exploratory lead · 34/100
Training-friendly
Active award
$41,998
FY 2026

Project Title

Role of interferon gamma in injury accelerated cystic kidney disease

Grant Number:

1F31DK146691-01

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/20/2026

End Date:

1/19/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Chronic kidney disease (CKD) is an urgent health problem in the U.S., afflicting ~15% of Americans and costing the healthcare system $120 billion/year. Despite the availability of glucose-normalizing drugs, diabetes remains the leading cause of renal failure. Current treatme...

Research Terms

<ADPKD><Academia><Acceleration><Adhesions><Adult Polycystic Kidney Disease><Adult-Onset Diabetes Mellitus><Affect><Age><Albuminuria><American><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Assay><Attenuated><Autosomal Dominant Polycystic Kidney><Autosomal Dominant Polycystic Kidney Disease><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><BB2><Bar Codes><Bioassay><Bioinformatics><Biological Assay><Blood Serum><Blood Urea><Blood Urea Nitrogen><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Brittle Diabetes Mellitus><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CD54><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Signaling><Cell-to-Cell Interaction><Cells><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Cilia><Clinical><Confocal Microscopy><Cyst><Cystic Kidney Diseases><Cystic Renal Diseases><D-Glucose><DNA><DNA Therapy><DNA mutation><Data><Dehydration><Deoxyribonucleic Acid><Dextrose><Diabetes Mellitus><Diabetic Kidney Disease><Diabetic Nephropathy><Disease><Disease Progression><Disorder><Dominant Polycystic Kidney Disease><Drugs><Endothelium><Epithelial Cells><Exhibits><FDA approved><Faculty><Fibrosis><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Folate><Folic Acid><Gene Transfer Clinical><Genes><Genetic><Genetic Change><Genetic Intervention><Genetic defect><Genetic mutation><Glucose><Goals><Health><Health Care><Health Care Costs><Health Care Systems><Health Costs><Height><Histology><Human><ICAM-1 Gene><ICAM1><ICAM1 gene><IDDM><IFN-Gamma><IFN-g><IFN-γ><IFNG><IFNγ><Immune><Immune Interferon><Immunes><Immunoblotting><In Vitro><Individual><Industry><Infection><Infiltration><Inflammation><Inflammatory><Injury><Injury to Kidney><Insulin-Dependent Diabetes Mellitus><Interferon Gamma><Interferon Type II><Intracellular Communication and Signaling><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><Ketosis-Resistant Diabetes Mellitus><Kidney><Kidney Diseases><Kidney Failure><Kidney Insufficiency><Kidney Urinary System><Knock-out><Knockout><Knowledge><Laboratories><Lead><Ligands><Link><Liquid substance><Liver><Macrophage><Maturity-Onset Diabetes Mellitus><Mediating><Medication><Medicine><Mentors><Mice><Mice Mammals><Miscellaneous Antibiotic><Modeling><Modern Man><Murine><Mus><Mutation><Mφ><NIDDM><Nephrology><Nephropathy><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Onset of illness><Patients><Pb element><Persons><Pharmaceutical Preparations><Phase><Phenotype><Polycystic Kidney><Polycystic Kidney Diseases><Population><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Proliferating><Proteins><Pteroylglutamic Acid><RNA Seq><RNA sequencing><RNAseq><Rag1><Rag1 Mouse><Receptor Protein><Renal Disease><Renal Failure><Renal Insufficiency><Renal Tissue><Renal function><Research><Research Associate><Research Resources><Resources><Role><Safety><Sampling><Serum><Severity of illness><Short interfering RNA><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Small Interfering RNA><Stable Diabetes Mellitus><Structure><Sudden-Onset Diabetes Mellitus><T-Cells><T-Lymphocyte><T1 DM><T1 diabetes><T1D><T1DM><T2 DM><T2D><T2DM><T4 Cells><T4 Lymphocytes><Technology><Testing><Therapeutic><Tissues><Training><Type 1 Diabetes Mellitus><Type 1 diabetes><Type 2 Diabetes Mellitus><Type 2 diabetes><Type I Diabetes Mellitus><Type II Diabetes Mellitus><Type II diabetes><Upregulation><Vitamin M><Western Blotting><Western Immunoblotting><Wild Type Mouse><Work><adult onset diabetes><ages><attenuate><attenuates><barcode><biological signal transduction><blood glucose regulation><body water dehydration><cell sorting><cell type><chronic kidney disease><conference><convention><cost><deep sequencing><deliver short interfering RNA><deliver siRNA><deliver small interfering RNA><delivery system for siRNA><delivery system for small interfering RNA><delivery vectors for siRNA><diabetes><disease onset><disease phenotype><disease severity><disorder onset><drug/agent><efficacy testing><flow cytophotometry><fluid><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genome mutation><genomic therapy><glucose control><glucose homeostasis><glucose regulation><heavy metal Pb><heavy metal lead><hepatic body system><hepatic organ system><hypertension control><hypertension management><in vivo><injured><injuries><insulin dependent diabetes><insulin dependent type 1><interest><interstitial><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><ketosis resistant diabetes><kidney disorder><kidney dysfunction><kidney fibrosis><kidney function><kidney injury><knock-down><knockdown><lFN-Gamma><lipid based nanoparticle><lipid nanoparticle><liquid><maturity onset diabetes><mouse model><murine model><post-doc><post-doctoral><post-doctoral trainee><precision medicine><precision-based medicine><prevent><preventing><prophylactic><protein blotting><receptor><recruit><renal><renal disorder><renal dysfunction><renal fibrosis><renal injury><repurposing><research associates><scRNA sequencing><scRNA-seq><screening><screenings><sex><short interfering RNA delivery><siRNA><siRNA delivery><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><small interfering RNA delivery><social role><summit><symposia><symposium><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic evaluation><therapeutic testing><thymus derived lymphocyte><tolvaptan><transcriptome sequencing><transcriptomic sequencing><type 2 DM><type I diabetes><type II DM><type one diabetes><type two diabetes><undergrad><undergraduate><undergraduate student><vitamin Bc><wildtype mouse>
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Y Hoang

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Exploratory lead · 32/100
Training-friendly
Career award
$18,209
FY 2026

Project Title

Quality control and spatial regulation of bacterial condensates

Grant Number:

5K99GM157383-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2025

End Date:

2/28/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACTS Condensates play a crucial role in spatially organizing and regulating biochemical reactions. Dynamic condensates arise from phase separation, while insoluble aggregates result from protein misfolding. Although both can manifest as fluorescent foci in bacterial cells, they ...

Research Terms

<Address><Affect><Award><Bacteria><Biochemical><Biochemical Reaction><Biologic Models><Biological Models><Biotech><Biotechnology><CO2><Carbon Dioxide><Carbonic Anhydride><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell division><Cells><Cellular Function><Cellular Inclusions><Cellular Physiology><Cellular Process><Chaperone><Communicable Diseases><Data><Development><Disease><Disorder><Drug Delivery><Drug Delivery Systems><E coli><E. coli><Ensure><Environment><Enzymatic Reaction><Escherichia coli><Esteroproteases><Exclusion><Exhibits><Faculty><Fixation><Foundations><Gel><Goals><Grant><Health><Human><Human Microbiome><In Vitro><Inclusion Bodies><Infectious Diseases><Infectious Disorder><Intervention><Knowledge><Laboratories><Liquid substance><Maintenance><Methods><Michigan><Microscopy><Model System><Modern Man><Molecular><Molecular Chaperones><Outcome><Pathogenesis><Pathway interactions><Peptidases><Peptide Hydrolases><Phase><Physical condensation><Play><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Process><Prokaryotae><Prokaryotic Cells><Protease Gene><Proteases><Protein Dynamics><Proteinases><Proteins><Proteolytic Enzymes><Publishing><Quality Control><Regulation><Research><Research Associate><Role><Solid><Structure><Subcellular Process><System><Therapeutic><Training><Training Support><Universities><Work><Writing><aberrant folded protein><aberrant folded proteins><aberrant protein folding><abnormal folded protein><abnormal folded proteins><abnormal protein folding><biophysical characteristics><biophysical characterization><biophysical measurement><biophysical parameters><biophysical properties><condensation><design><designing><developmental><fluid><fluidity><health application><human-associated microbiome><improved><innovate><innovation><innovative><insoluble aggregate><liquid><misfolded protein><misfolded proteins><nano meter scale><nano meter sized><nanometer scale><nanometer sized><nanoscale><new approaches><novel approaches><novel strategies><novel strategy><pathologic protein folding><pathway><post-doc><post-doctoral><post-doctoral trainee><post-doctoral training><programs><prokaryote><protein aggregate><protein aggregation><protein complex><protein misfolding><proteotoxic protein><proteotoxin><reconstitute><reconstitution><research associates><sample fixation><single molecule><social role><success><superresolution imaging><therapeutic agent development><therapeutic development><therapeutic target><tool>
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Shuting Zheng

UNIVERSITY OF TEXAS AT AUSTIN, AUSTIN, TX

Exploratory lead · 30/100
Very recent
Active award
$249,430
FY 2026

Project Title

Tracking Depression and Associated Modifiable Social-Emotional Factors in Adolescent Girls with Autism

Grant Number:

5R00MH131841-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Adolescent girls with autism spectrum disorder (ASD) are at high risk for depression due to risk factors associated with female sex and ASD-related challenges. However, little empirical evidence is available on the psychosocial mechanisms of depression onset and change for g...

Research Terms

<10 year old><10 years of age><12-20 years old><14 year old><14 years of age><ASD><Acceleration><Adolescence><Adolescent><Adolescent Youth><Affective Disorders><Age><Autism><Autistic Disorder><Behavioral><Characteristics><Clinical><Coping Skills><Data><Data Analyses><Data Analysis><Data Collection><Development><Diagnosis><Early Infantile Autism><Ecological momentary assessment><Emotional><Emotional Depression><Emotional well being><Emotions><Ensure><Equation><Feels well><Female><Female Adolescents><Friendships><Goals><Impairment><Individual><Infantile Autism><Institution><Intervention><Investigators><Kanner's Syndrome><Learning><Life><Loneliness><Longitudinal Studies><Longitudinal Surveys><Maps><Measurement><Measures><Mental Depression><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Mentors><Methodology><Methods><Modeling><Mood Disorders><Moods><Motivation><NIMH><National Institute of Mental Health><Normal mental condition><Normal mental state><Normal psyche><Pattern><Phase><Population><Position><Positioning Attribute><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Protocol><Protocols documentation><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Psychological Impact><Psychological Well Being><Psychopathology><Puberty><Reporting><Research><Research Activity><Research Personnel><Research Resources><Researchers><Resources><Risk><Risk Factors><Sampling><Sense of well-being><Social Interaction><Strategic Planning><Symptoms><Techniques><Time><Training><Training Activity><Vulnerable Populations><Well in self><Youth><Youth 10-21><abnormal psychology><adolescence (12-20)><adolescent girl><adolescent mental health><adolescent with ASD><adolescent with autism><adolescent with autism spectrum disorder><adolescents on the autism spectrum><age 10><age 10 years><age 14><age 14 years><ages><autism spectral disorder><autism spectrum disorder><autistic adolescent><autistic individuals><autistic people><autistic spectrum disorder><autistic youth><boys><commit suicide><completed suicide><coping strategy><customized therapy><customized treatment><data interpretation><depression><depression prevention><depression symptom><depressive><depressive symptoms><design><designing><develop therapy><developmental><early adolescence><effective intervention><emotion regulation><emotional experience><emotional factor><emotional regulation><emotional wellbeing><emotional wellness><experience><fourteen year old><fourteen years of age><girls><high risk><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><interest><intervention development><investigate longitudinal><juvenile><juvenile human><lonely><long-term study><longitudinal investigation><longitudinal outcome studies><longitudinal research><longitudinal research study><male><mental illness><mental well-being><mental wellbeing><mental wellness><mood symptom><negative mood><novel><patient specific therapies><patient specific treatment><peer victimization><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><programs><protective factors><psychiatric illness><psychological disorder><psychological wellbeing><psychological wellness><psychosocial><self wellness><sense of wellbeing><sex><skills><social><social relationships><study longitudinal><success><survey longitudinal><tailored medical treatment><tailored therapy><tailored treatment><ten year old><ten years of age><therapy development><training module><treatment development><treatment strategy><unique treatment><vulnerable group><vulnerable individual><vulnerable people><youth age><youth on the autism spectrum><youth with ASD><youth with autism><youth with autism spectrum disorder><♀><♂>
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Daniel Lench

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Exploratory lead · 30/100
Very recent
Active award
$249,000
FY 2026

Project Title

A Neural Basis for Cognitive Decline Following Deep Brain Stimulation

Grant Number:

5R00NS131447-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Deep Brain Stimulation (DBS) targeting the subthalamic nucleus (STN) is an established therapy for PD patients with motor fluctuations and dyskinesias. While STN DBS is an effective treatment for motor symptoms, it can produce unintended side effects cognition including exec...

Research Terms

<Abnormal Movements><Acceleration><Acetylcholine><Affect><Anatomic Sites><Anatomic structures><Anatomy><Anterior><Attention><Attentional deficit><Award><Basal Nucleus of Meynert><Behavioral><Body Tissues><Brain><Brain Nervous System><Brain region><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cerebral cortex><Clinical><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive Manifestations><Cognitive Symptoms><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Corpus Striatum><Corpus striatum structure><DWI (diffusion weighted imaging)><DWI-MRI><Data><Deep Brain Stimulation><Diffusion><Diffusion MRI><Diffusion Magnetic Resonance Imaging><Diffusion Weighted MRI><Diffusion weighted imaging><Diffusion-weighted Magnetic Resonance Imaging><Disabling><Disturbance in cognition><Dopamine><Dorsal><Dose><Dysfunction><Dyskinesia Syndromes><Dyskinesias><Dyskinetic syndrome><Encephalon><Evaluation><Faculty><Frequencies><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Hydroxytyramine><Image><Impaired cognition><Individual><Interruption><K-Awards><K-Series Research Career Programs><Knowledge><Language><Language Disorders><Lead><Lesion><Measures><Medial><Memory><Mentors><Mission><Motor><Movement Disorder Syndromes><Movement Disorders><NIH><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><National Institutes of Health><Nerve Degeneration><Nerve Transmitter Substances><Nervous System Diseases><Nervous System Disorder><Neurocognitive><Neurologic Disorders><Neurological Disorders><Neurologist><Neuron Degeneration><Neuropsychologies><Neuropsychology><Neurotransmitters><Nucleus Basalis of Meynert><Nucleus Subthalamicus><Operative Procedures><Operative Surgical Procedures><Paralysis Agitans><Parkinson><Parkinson Disease><Participant><Pathway interactions><Patient Selection><Patients><Pb element><Phase><Physiopathology><Position><Positioning Attribute><Postoperative><Postoperative Period><Prefrontal Cortex><Primary Parkinsonism><QOL><QOL improvement><Quality of life><Research><Research Career Program><STN stimulation><Scanning><Schedule><Secure><Source><Specificity><Striate Body><Striatum><Structure><Structure of subthalamic nucleus><Subthalamic Nucleus><Surgical><Surgical Interventions><Surgical Procedure><System><Tissues><Training><United States National Institutes of Health><Visuospatial><attentive deficit><career><cholinergic><cingulate cortex><cognitive defects><cognitive dysfunction><cognitive loss><cognitive performance><cognitive reserve><dMRI><decrease disability><decrease in disability><diffused><diffuses><diffusing><diffusion tensor imaging><diffusions><disability reduction><disease duration><disease length><effective therapy><effective treatment><executive control><executive function><experience><fMRI><heavy metal Pb><heavy metal lead><illness length><imaging><imaging study><improved><improvements in QOL><improvements in quality of life><innervation><language deficit><lessen disability><minimize disability><mitigate disability><motor symptom><nerve supply><neural><neural control><neural degeneration><neural network><neural regulation><neurocognitive test><neurodegeneration><neurodegenerative><neuroimaging biomarker><neuroimaging marker><neurological degeneration><neurological disease><neuromodulation><neuromodulatory><neuronal degeneration><neuropsychologic><neuroregulation><nucleus basalis><pathophysiology><pathway><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><programs><quality of life improvement><recruit><reduction in disability><side effect><skills><slow disability><striatal><subthalamic nucleus stimulation><surgery><tenure process><tenure track><tool><visual spatial>
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Dario F De Jesus

UNIVERSITY OF CHICAGO, CHICAGO, IL

Exploratory lead · 30/100
Very recent
Active award
$249,000
FY 2026

Project Title

Interrogating the role of m6A mRNA methylation in the aging of the β-cell and diabetes

Grant Number:

5R00DK135927-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2025

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Although the etiopathogenesis of Type 1 (T1D) and Type 2 diabetes (T2D) is different, decreased functional β-cell mass is a central feature in both diseases. Concerted research efforts aim at developing strategies to improve β-cell survival and restore β-cell function in patients wi...

Research Terms

<21+ years old><ATM activation><Acceleration><Adeno-Associated Viruses><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Age><Aging><Area><Autoimmune><Automobile Driving><Beta Cell><Bioinformatics><Biology of Aging><CLIP-Seq><Candidate Disease Gene><Candidate Gene><Cell Aging><Cell Function><Cell Line><Cell Physiology><Cell Process><Cell Senescence><Cell Survival><Cell Viability><Cell secretion><CellLine><Cellular Aging><Cellular Function><Cellular Physiology><Cellular Process><Cellular Secretion><Cellular Senescence><Chemicals><Complement><Complement Proteins><DNA Damage><DNA Injury><DNA Molecular Biology><Data><Data Analyses><Data Analysis><Data Set><Dependoparvovirus><Dependovirus><Development><Diabetes Mellitus><Disease><Disorder><EC 2.1.1><Exhibits><Female><Foundations><Future><Gene Expression><GeneHomolog><Genes><Genetic Models><Goals><HITS-CLIP><Health><High Fat Diet><High-throughput sequencing of CLIP cDNA library><Homolog><Homologous Gene><Homologue><Human><Immune Precipitation><Immunoprecipitation><Impairment><In vivo analysis><Inbred NOD Mice><Inflammation><Insulin Cell><Insulin Resistance><Insulin Secreting Cell><Intermediary Metabolism><Investigators><KO mice><Ketosis-Resistant Diabetes Mellitus><Knock-out Mice><Knockout Mice><Maturity-Onset Diabetes Mellitus><Messenger RNA><Metabolic Processes><Metabolism><Methods><Methylation><Methyltransferase><Mice><Mice Mammals><Modern Man><Modification><Molecular><Molecular Biology><Molecular Target><Murine><Mus><NIDDM><NOD Mouse><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Non-Obese Diabetic Mice><Non-Polyadenylated RNA><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nonobese Diabetic Mouse><Null Mouse><Pathway interactions><Patients><Phase><Physiology><Publishing><RNA><RNA Gene Products><RNA Splicing><Regulation><Replicative Senescence><Research><Research Personnel><Researchers><Ribonucleic Acid><Ribonucleosides><Role><Slow-Onset Diabetes Mellitus><Splicing><Stable Diabetes Mellitus><Strains Cell Lines><Subcellular Process><T2 DM><T2D><T2DM><Testing><Time><Training><Transcript><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Upregulation><Work><adeno associated virus group><adult onset diabetes><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><aged><ages><ataxia telangiectasia mutated activation><attenuation of senescence><beta-D-Galactosidase><beta-D-Galactoside galactohydrolase><beta-Galactosidase><candidate validation><career><compare to control><comparison control><complementation><crosslink><crosslinking and immunoprecipitation sequencing><cultured cell line><data interpretation><decline in function><decline in functional status><decrease senescence><delay senescence><developmental><diabetes><driving><experience><experiment><experimental research><experimental study><experiments><functional decline><functional status decline><hallmarks of aging><improved><in vivo><in vivo evaluation><in vivo testing><insight><insulin resistant><insulin tolerance><islet><ketosis resistant diabetes><lac Z Protein><mRNA><mRNA Translation><maturity onset diabetes><methylase><methylome><mouse genetics><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><non-obese diabetic (NOD) mice><nonobese diabetic (NOD) mice><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><pillars of aging><protein complex><reduce senescence><reducing cellular senescence><replicative aging><repress senescence><response><scRNA sequencing><scRNA-seq><senescence><senescence mitigation><senescent><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stressor><suppress senescence><therapeutic agent development><therapeutic development><therapeutic target><transcriptomics><transmethylase><type 1 and type 2 diabetes><type 2 DM><type I and type II diabetes><type II DM><type two diabetes><β-D-Galactosidase><β-D-Galactoside galactohydrolase><β-Galactosidase><β-cell><β-cells><βCell><♀>
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Michelle M Williams

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 30/100
Very recent
Active award
$249,000
FY 2026

Project Title

Targeting heme metabolism to initiate an immune response against breast cancer liver metastasis

Grant Number:

5R00CA266748-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2022

End Date:

4/30/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Breast cancer (BC) remains the second leading cause of cancer-related deaths in women in the United States and late-stage metastatic BC remains incurable. The recent approval of immune checkpoint inhibitors targeting PD-1 or PD-L1 in metastatic triple-negative BC (TNBC) dem...

Research Terms

<Address><Animals><Antigen Presentation><Assay><B7-H1><Bilirubin><Bilirubin IX alpha><Bioassay><Biological Assay><Biology><Blocking Antibodies><Body Tissues><Breast Cancer><Breast Cancer Cell><Breast Cancer Patient><Breast Metastasis><Breast Tumor Patient><CD274><Cancer Cause><Cancer Etiology><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell secretion><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Secretion><Cessation of life><Checkpoint inhibitor><Clinical><Colorado><Conditioned Culture Media><Conditioned Medium><D-Glucose><Data><Death><Death Rate><Dextrose><Disease><Disorder><Enzyme Gene><Enzymes><Faculty><Ferroprotoporphyrin><Foundations><Funding><Gene Transcription><Genetic><Genetic Transcription><Glucose><Glycolysis><Goals><HIF 1><HIF-1 protein><HIF1><HIF1 protein><HO-1 enzyme><HO1><HO2><HSP32><Heme><Hepatic Cells><Hepatic Disorder><Hepatic Neoplasm Secondary><Hepatic Parenchymal Cell><Hepatic metastasis><Hepatocyte><High Prevalence><Human><Immune><Immune checkpoint inhibitor><Immune mediated therapy><Immune response><Immunes><Immunity><Immunologically Directed Therapy><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Immunotherapy><Institution><Intermediary Metabolism><Knowledge><Kupffer Cells><Liver><Liver Cells><Liver diseases><Liver secondaries><Liver secondary cancer><Macrophage><Malignant Breast Neoplasm><Mediating><Medical><Mentors><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Metastasis><Metastasis to the Lung><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Neoplasm to the Liver><Metastatic Neoplasm to the Lung><Metastatic Tumor><Metastatic Tumor to the Liver><Metastatic Tumor to the Lung><Metastatic breast cancer><Metastatic malignant neoplasm to liver><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Mφ><Neoplasm Metastasis><Organ><PD 1><PD-1><PD-1/PD-L1><PD-1/PDL1><PD-L1><PD1><PD1-PD-L1><PD1/PD-L1><PD1/PDL1><PDL-1><Paper><Pathway interactions><Patients><Phase><Postdoc><Postdoctoral Fellow><Procedures><Production><Programmed Cell Death 1 Ligand 1><Programmed Death Ligand 1><Protoheme><QOL><Quality of life><RNA Expression><Recurrent Malignant Neoplasm><Recurrent Malignant Tumor><Regulation><Regulatory T-Lymphocyte><Research><Research Associate><Research Specimen><Resistance><Secondary Neoplasm><Secondary Tumor><Shapes><Site><Social Support System><Specimen><Stellate Sinusoidal Macrophage><Subcellular Process><Support System><Supporting Cell><T-Cells><T-Lymphocyte><TNBC><Testing><Time><Tissues><Training><Transcription><Treg><Tumor Cell><Tumor Immunity><United States><Universities><Upregulation><Women's mortality><Work><aggressive breast cancer><anti-tumor immune response><anti-tumor immunity><antitumor immunity><breast cancer metastasis><breast tumor cell><cancer cell metabolism><cancer immunity><cancer immunology><cancer metabolism><cancer metastasis><cancer recurrence><career><cytokine><cytotoxic><death among females><death among women><death in females><death in women><exhaust><female death><female mortality><ferroheme><heme oxygenase-1><hemeoxygenase 1><hepatic body system><hepatic disease><hepatic organ system><hepatopathy><host response><hypoxia inducible factor 1><immune check point inhibitor><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive response><improved><in vivo><individuals with breast cancer><knowledge base><liver disorder><liver function><liver macrophage><liver metastases><lung metastasis><malignant breast tumor><malignant liver neoplasm, specified as secondary><metabolism measurement><metabolomics><metabonomics><metastasis in the liver><metastasis to the liver><metastasize to the liver><metastasize to the lung><metastatic breast tumor><metastatic cancer to liver><metastatic liver><metastatic liver neoplasm><metastatic mammary cancer><metastatic mammary tumor><mortality><mortality among females><mortality among women><mortality in females><mortality in women><mortality rate><neoplasm immunology><neoplastic cell><new approaches><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel approaches><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><overexpress><overexpression><pathway><patients with breast cancer><person with breast cancer><pharmacologic><post-doc><post-doctoral><post-doctoral trainee><programmed cell death 1><programmed cell death ligand 1><programmed cell death protein 1><programmed cell death protein ligand 1><programmed death 1><programs><protein death-ligand 1><pulmonary metastasis><regulatory T-cells><research associates><resistant><response><secondary liver malignancy><secondary malignant liver neoplasm><shRNA><short hairpin RNA><skills><sle2><small hairpin RNA><success><systemic lupus erythematosus susceptibility 2><tenure process><tenure track><thymus derived lymphocyte><triple-negative breast cancer><triple-negative invasive breast carcinoma><tumor><tumor cell metabolism><tumor cell metastasis><tumor immunology><tumor metabolism><women's death>
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Wagner Silva Dantas

UNIVERSITY OF OREGON, EUGENE, OR

Exploratory lead · 30/100
Very recent
Active award
$249,000
FY 2026

Project Title

The Role of Nuclear Factor Erythroid 2-related factor 2 in Sarcopenic Obesity

Grant Number:

5R00AG083239-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Sarcopenic obesity is a debilitating condition that increases the risk of frailty, loss of autonomy, institutionalization, and death in older adults. Currently, obesity medications and lifestyle/behavioral interventions have limited efficacy for sarcopenia, worsening quality...

Research Terms

<Active Oxygen><Acute><Address><Affect><Aging><Antioxidants><Apoptosis><Apoptosis Pathway><Area><Attenuated><Award><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biogenesis><Biology><Career Transition Award><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Signaling><Cells><Cessation of life><Chlorochin><Chloroquine><Chronic Disease><Chronic Illness><Conditioning Therapy><Death><Dedications><Defect><Dephosphin><Development><Drugs><Dynamin><EXTMR><Elderly><Equilibrium><Erythroid><Extramural><Extramural Activities><Fumarates><Funding><Future><Generations><Genetic><Geroscience><Goals><Health><Health Care Costs><Health Costs><Hospital Admission><Hospitalization><Impairment><In Vitro><Institutionalization><Intracellular Communication and Signaling><Khingamin><Knowledge><Learning><Life Style><Lifestyle><Link><Lipids><MG-132><MG132><Mediating><Medication><Metabolic><Mice><Mice Mammals><Mitochondria><Mitochondria RNA><Mitochondrial RNA><Modeling><Molecular><Morbidity><Murine><Mus><Muscle><Muscle Atrophy><Muscle Fibers><Muscle Mitochondria><Muscle Tissue><Muscle function><Muscular Atrophy><Myotubes><NF-E2 protein><NF-E2 transcription factor><NFE2 protein><NIH><National Institutes of Health><Non-Polyadenylated RNA><Nuclear><Obesity><Organelles><Origin of Life><Oxidation-Reduction><Oxidative Stress><Oxidative Stress Induction><Oxygen Radicals><Pathway interactions><Patients><Pharmaceutical Preparations><Phase><Phosphorylation><Physical Function><Position><Positioning Attribute><Post-Transcriptional Gene Silencing><Postdoc><Postdoctoral Fellow><Pro-Oxidants><Probability><Production><Programmed Cell Death><Protein Biosynthesis><Protein Import><Protein Phosphorylation><Proteins><Public Health><QOL><QOL improvement><Quality Control><Quality of life><RNA><RNA Gene Products><RNA Interference><RNA Silencing><RNAi><Reactive Oxygen Species><Redox><Regulation><Research><Research Associate><Research Design><Rhabdomyocyte><Ribonucleic Acid><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Risk><Role><Sarcosomes><Scientist><Sequence-Specific Posttranscriptional Gene Silencing><Series><Short interfering RNA><Signal Transduction><Signal Transduction Systems><Signaling><Skeletal Fiber><Skeletal Muscle><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Small Interfering RNA><Study Type><Syndrome><System><Techniques><Testing><Therapeutic><Time><Training><Transgenic Mice><Underrepresented Ethnic Minority><Underrepresented Minority><United States National Institutes of Health><Voluntary Muscle><Weight><adiposity><advanced age><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age-related disease><age-related disorder><age-related impairment><aged><aged mice><aged mouse><attenuate><attenuates><balance><balance function><behavior intervention><behavioral intervention><biological signal transduction><biomedical profession><career><cell culture><cell cultures><chronic disorder><corpulence><developmental><drug/agent><effective therapy><effective treatment><elderly mice><elderly patient><energy efficiency><experiment><experimental research><experimental study><experiments><fitness><frailty><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><geriatric><geroscientific><graduate student><healthspan><healthy life span><high risk><implementation facilitation><improved><improvements in QOL><improvements in quality of life><inhibitor><insight><life span><lifespan><loss of function><mRNA Decay><mitochondrial><mitochondrial DNA mutation><mtDNA mutation><mtRNA><muscle breakdown><muscle bulk><muscle degradation><muscle deterioration><muscle form><muscle loss><muscle mass><muscle strength><muscle wasting><muscular><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><nuclear factor-erythroid 2><obese patients><old mice><older adult><older adulthood><older patient><oxidation><oxidation reduction reaction><oxidative damage><oxidative injury><pathway><patients with obesity><pharmacologic><post-doc><post-doctoral><post-doctoral trainee><prevent><preventing><programs><protein expression><protein homeostasis><protein synthesis><proteostasis><quality of life improvement><research associates><sarcopenia><sarcopenic><sarcopenic obesity><senior citizen><siRNA><skills><social role><study design><trafficking><treatment strategy><under-representation of minorities><under-represented minority><underrepresentation of minorities><weights>
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Le Xu

CINCINNATI CHILDRENS HOSP MED CTR, CINCINNATI, OH

Exploratory lead · 30/100
Very recent
Active award
$249,000
FY 2026

Project Title

Frontiers at the edge: Subpleural fibroblasts orchestrate pulmonary fibrosis progression

Grant Number:

4R00HL171830-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/2/2026

End Date:

3/31/2029

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project summary Idiopathic pulmonary fibrosis (IPF) is the single most common and lethal type of lung fibrosis of unknown cause, which starts with the build-up of scar tissue from the edges of the lung, and advances toward the inside center over time. This intriguing edge-to-center fibrotic progres...

Research Terms

<Address><Basal Transcription Factor><Basal transcription factor genes><Biological><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood monocyte><Body Tissues><Causality><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Characteristics><Chemotactic Cytokines><Chronic><Cicatrix><Cues><Cyst><Data><Deposit><Deposition><Development><Diagnosis><Discipline><Disease><Disorder><Early Diagnosis><Early treatment><Epithelial Cells><Epithelium><Etiology><Exhibits><Extracellular Matrix Proteins><Fibroblasts><Fibrosing Alveolitis><Fibrosis><Fibrotic lesions in lung><General Transcription Factor Gene><General Transcription Factors><Goals><Homolog of Drosophila TWIST 1><Homolog of Drosophila TWIST1><Homologous Chemotactic Cytokines><Human><Immunology><Inflammation><Intercrines><Interstitial Lung Diseases><Intracellular Communication and Signaling><Investigators><Knowledge><Ligands><Lineage Tracing><Lung><Lung Alveolar Epithelia><Lung Respiratory System><Lung Tissue Fibrosis><Lung damage><Lung scar><Lung tissue scar><Macrophage><Marrow Neutrophil><Marrow monocyte><Mechanics><Mentors><Mesenchymal><Mesothelial Cell><Mesothelium><Modern Man><Molecular><Myeloid Cells><Myofibroblast><Mφ><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Pathologic><Pleural><Pneumonectomy><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Process><Productivity><Profibrotic factor><Profibrotic signal><Pulmonary Fibrosis><Pulmonary Scar><Pulmonary Tissue fibrosis><Receptor Protein><Research Personnel><Researchers><Role><SIS cytokines><Scarring at the lung><Scarring in the lung><Scars><Signal Transduction><Signal Transduction Systems><Signaling><Single cell seq><Source><TWIST gene><TWIST1><TWIST1 gene><Technology><Testing><Time><Tissues><Training><Transcription Factor Proto-Oncogene><Transcription Factor TWIST><Transcription factor genes><Validation><WAGR><WT1><WT1 Gene Product><WT1 Protein><WT1 gene><WT33><Wilms Tumor 1><Wilms tumor suppressor WT1><Zea><alveolar epithelium><biologic><biological signal transduction><career><causation><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><chemoattractant cytokine><chemokine><cytokine><developmental><diffuse interstitial pulmonary fibrosis><disease causation><early detection><early therapy><epigenomics><epithelial injury><fibrogenesis><fibrosis in the lung><fibrotic lung><fibrotic lung disease><fibrotic pulmonary disease><genetic approach><genetic strategy><idiopathic pulmonary fibrosis><in vivo><infancy><infantile><injured><insight><interstitial><lung fibrosis><lung injury><mechanic><mechanical><monocyte><mortality><mouse model><multi-modality><multimodality><murine model><neutrophil><novel><progenitor><pulmonary damage><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><receptor><recruit><single cell next generation sequencing><single cell sequencing><single cell technology><social role><synergism><transcription factor><twist protein><validations>
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Bryan Cruz

UNIVERSITY OF TENNESSEE HEALTH SCI CTR, MEMPHIS, TN

Exploratory lead · 30/100
Very recent
Active award
$249,000
FY 2026

Project Title

Extended amygdala somatostatin role in post-traumatic stress and alcohol use disorder

Grant Number:

4R00AA031718-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/10/2026

End Date:

2/28/2029

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Post-traumatic stress and alcohol use disorder (PTSD/AUD) are frequently comorbid and are a major US health burden. Individuals with comorbid PTSD/AUD manifest complex symptoms including greater risk for alcohol drinking and relapse, sleep disturbances, hyperarousal, drinkin...

Research Terms

<ACTH-Releasing Factor><Address><Affect><Aggression><Aggressive behavior><Agonist><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohols><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Anti-Anxiety Agents><Anti-Anxiety Drugs><Anxiety><Anxiolytic Agents><Anxiolytics><Award><Bed Nucleus of Stria Terminalis><Behavior Disorders><Behavioral><Brain><Brain Nervous System><Brain region><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><CRF-41><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Common Rat Strains><Complement><Complement Proteins><Complex><Corticoliberin><Corticosterone><Corticotropin-Releasing Factor><Corticotropin-Releasing Factor-41><Corticotropin-Releasing Hormone><Corticotropin-Releasing Hormone-41><Cyclic Somatostatin><DREADDs><Data><Decrease health disparities><Development><Diagnosis><Differences between sexes><Differs between sexes><Disease><Disorder><Electrophysiology><Electrophysiology (science)><Encephalon><EtOH drinking><EtOH use><Feeling suicidal><Female><Fore-Brain><Forebrain><Gene Transfer><Genetic><Goals><Growth Hormone Inhibiting Factors><Growth Hormone-Inhibiting Hormone><Health><Health disparity mitigation><Health disparity reduction><Heavy Drinking><High Prevalence><History><In Situ Hybridization><Individual><Infusion><Infusion procedures><Interdisciplinary Research><Interdisciplinary Study><Intracellular Communication and Signaling><Investigation><KO mice><Knock-out Mice><Knockout Mice><Label><Lateral><Literature><Lower health disparities><Mentors><Methods><Minor Tranquilizing Agents><Mission><Mitigate health disparities><Modeling><Molecular><Multidisciplinary Collaboration><Multidisciplinary Research><NIAAA><National Institute on Alcohol Abuse and Alcoholism><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neuropeptides><Neurophysiology / Electrophysiology><Neurosciences><Non-Polyadenylated RNA><Null Mouse><PTSD><Peptides><Phase><Phenotype><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Prevention><Property><Prosencephalon><Public Health><RNA><RNA Gene Products><Rat><Rats Mammals><Rattus><Receptor Protein><Recording of previous events><Reduce health disparities><Regulation><Research><Ribonucleic Acid><Risk><Rodent><Rodent Model><Rodentia><Rodents Mammals><Role><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SRIH><SRIH Receptors><SRIH-14><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Sex Differences><Sexual differences><Signal Transduction><Signal Transduction Systems><Signaling><Site><Sleep disturbances><Slice><Somatostatin><Somatostatin Receptor><Somatostatin-14><Somatotropin Release Inhibiting Factors><Somatotropin Release Inhibiting Hormone Receptors><Somatotropin Release-Inhibiting Hormone><Stress><Stria Terminalis Nucleus><Structure><Structure of terminal stria nuclei of preoptic region><Suicidal thoughts><Symptoms><Synapses><Synaptic><System><Testing><Therapeutic Uses><Training><Violence><Viral><Viral Genes><Vulnerable Populations><Work><aberrant sleep><addiction><addictive disorder><alcohol exposed><alcohol exposure><alcohol ingestion><alcohol intake><alcohol product use><alcohol relapse><alcohol risk><alcohol use><alcohol use disorder><alcoholic beverage consumption><alcoholic drink intake><amygdaloid nuclear complex><anxiety-like behavior><associated symptom><behavior phenotype><behavioral disorder><behavioral pharmacology><behavioral phenotyping><biological signal transduction><career development><cell type><co-morbid><co-morbid symptom><co-morbidity><co-occuring symptom><comorbid symptom><comorbidity><complementation><concurrent symptom><confocal imaging><cooccuring symptom><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><corticotropin releasing hormone><designer receptors exclusively activated by designer drugs><developmental><disrupted sleep><disturbed sleep><drink heavily><drinking><electrophysiological><ethanol consumption><ethanol drinking><ethanol exposed><ethanol exposure><ethanol ingestion><ethanol intake><ethanol product use><ethanol relapse><ethanol use><ethanol use disorder><excessive alcohol consumption><excessive alcohol ingestion><excessive alcohol intake><excessive drinking><excessive ethanol ingestion><exposed to alcohol><exposed to ethanol><exposure to alcohol><exposure to ethanol><extreme drinking><growth hormone release inhibiting factor><heavy alcohol use><histories><impaired sleep><in situ Hybridization Genetics><in situ Hybridization Staining Method><infusions><insight><interdisciplinary approach><irregular sleep><male><multidisciplinary approach><negative emotional state><neural circuit><neural circuitry><neurocircuitry><neuronal><neurophysiological><neurophysiology><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><overexpress><overexpression><pharmacobehavioral><pharmacologic><post-trauma stress><post-trauma stress disorder><post-traumatic stress><posttrauma stress><posttrauma stress disorder><posttraumatic stress><prevent><preventing><programs><rapid growth><receptor><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><sex><sex based differences><sex dimorphism><sex-dependent differences><sex-related differences><sex-specific differences><sexual dimorphism><sexually dimorphic><sleep disruption><sleep dysregulation><sleep/wake disruption><sleep/wake disturbance><social role><stress disorder><stress related disorder><suicidal ideation><suicidal thinking><suicide ideation><suicide rate><symptom association><symptom comorbidity><synapse><synapse function><synaptic circuit><synaptic circuitry><synaptic function><therapeutic candidate><thoughts about suicide><traumatic neurosis><violent><violent behavior><vulnerable group><vulnerable individual><vulnerable people><♀><♂>
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Mehmet Neset Ozel

STOWERS INSTITUTE FOR MEDICAL RESEARCH, KANSAS CITY, MO

Exploratory lead · 30/100
Very recent
Active award
$249,000
FY 2026

Project Title

Gene Regulatory Networks of Synaptic Specificity

Grant Number:

5R00NS125117-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2022

End Date:

4/30/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Neuronal type identity is central to the development and function of neural circuits, as it instructs both the connectivity of neurons as well as their synaptic and electrophysiological properties. Neuronal fates are thought to be controlled by combinations of transcription ...

Research Terms

<21+ years old><ATAC sequencing><ATAC-seq><ATACseq><Acquired brain injury><Address><Adult><Adult Human><Affect><Algorithms><Assay for Transposase-Accessible Chromatin using sequencing><Award><Basal Transcription Factor><Basal transcription factor genes><Biologic Models><Biological Models><Blindness><Brain><Brain Injuries><Brain Nervous System><Brain region><Calcium><Candidate Disease Gene><Candidate Gene><Cell Body><Cell Surface Proteins><Cells><Chromatin><Code><Coding System><Collaborations><Complex><Computational Technique><Computer Models><Computerized Models><Corpora Bigemina><Data><Data Set><Decision Making><Defect><Detection><Development><Developmental Gene><Drosophila><Drosophila genus><Electrophysiology><Electrophysiology (science)><Enabling Factors><Encephalon><Engineering><Environment><Equilibrium><Flies><Gene Action Regulation><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Transcription><Genetic study><Goals><Human><Image><In vivo two-photon calcium imaging><Individual><Knowledge><Lead><Learning><Link><Logic><Mediating><Mentors><Mentorship><Methods><Model System><Modeling><Modern Man><Modification><Molecular><Morphology><Motion><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System><Neural Cell><Neural Stem Cell><Neurocyte><Neurodevelopmental Disorder><Neurologic Body System><Neurologic Organ System><Neurological Development Disorder><Neuron Degeneration><Neurons><Neurophysiology - biologic function><Neurophysiology / Electrophysiology><New York><Optic Lobe><Output><Pb element><Phase><Physiologic><Physiological><Physiology><Process><Progenitor Cells><Property><RNA Expression><Regenerative Medicine><Research><Research Resources><Resources><Retina><Specific qualifier value><Specificity><Specified><Synapses><Synaptic><System><Techniques><Testing><Time><Training><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transplantation><Universities><Visual><Visual System><Work><adulthood><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><balance><balance function><brain damage><brain-injured><cell replacement therapy><cell replacement treatment><cell type><computational modeling><computational models><computer based models><computerized modeling><developmental><effective therapy><effective treatment><electrophysiological><experiment><experimental research><experimental study><experiments><fly><fruit fly><gene regulatory network><global gene expression><global transcription profile><heavy metal Pb><heavy metal lead><iPS><iPSC><iPSCs><imaging><improved><in vivo><in vivo calcium imaging><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><interest><machine learning based framework><machine learning framework><model building><nerve stem cell><network models><neural><neural circuit><neural circuitry><neural control><neural degeneration><neural function><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural regulation><neural stem and progenitor cells><neurocircuitry><neurodegeneration><neurodegenerative><neurodevelopmental disease><neurogenic progenitors><neurogenic stem cell><neurological degeneration><neuromodulation><neuromodulatory><neuron development><neuron progenitors><neuronal><neuronal degeneration><neuronal development><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><neuroregulation><new approaches><novel approaches><novel strategies><novel strategy><postmitotic><postsynaptic><progenitor and neural stem cells><programs><response><scATAC sequencing><scATAC-seq><scRNA sequencing><scRNA-seq><single cell ATAC-seq><single cell ATAC-sequencing><single cell Assay for Transposase Accessible Chromatin sequencing><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell genomics><single cell sequencing assay for transposase accessible chromatin><single cell transcriptomic profiling><single-cell Assay for Transposase-Accessible Chromatin with sequencing><single-cell RNA sequencing><single-cell assay for transposase-accessible chromatin using sequencing><single-cell assay for transposase-accessible chromatin-seq><stem cells><synapse><synapse formation><synaptic circuit><synaptic circuitry><synaptogenesis><tool><transcription factor><transcriptome><transdifferentiation><transplant><vision loss><visual loss>
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Maryam Hajfathalian

NEW JERSEY INSTITUTE OF TECHNOLOGY, NEWARK, NJ

Exploratory lead · 30/100
Very recent
Active award
$249,000
FY 2026

Project Title

Anti-biofilm laser-mediated photothermal ablation via complex noble metal nanostructures

Grant Number:

5R00EB028838-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract This proposal describes a research and training program to advance my academic career in biofilm treatment and facilitate my transition towards independence. Over the past years, I have acquired a broad scientific background and extensive research experience in multiple fiel...

Research Terms

<Ablation><Abscission><Acceleration><Affect><Animal Model><Animal Models and Related Studies><Anti-Bacterial Agents><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotics><Architecture><Area><Award><Bacteria><Behavior><Binding><Bladder><Bladder Urinary System><Body Surface><Body Tissues><CAT scan><CT X Ray><CT Xray><CT imaging><CT scan><Cancers><Cardiac Valves><Cardiovascular Diseases><Caries><Cell Body><Cell-Extracellular Matrix><Cells><Chemistry><Clinical><Clinical Treatment><Communicable Diseases><Competence><Complex><Computed Tomography><Contrast Agent><Contrast Drugs><Contrast Media><Cutaneous Disorder><Data><Dental Alloys><Dental Decay><Dental caries><Dermatology><Dermatoses><Development><Devices><Disease><Disorder><Drug Delivery><Drug Delivery Systems><ECM><Effectiveness><Elements><Engineering><Engineering / Architecture><Excision><Exposure to><Extirpation><Extracellular Matrix><Formulation><Fostering><General Radiology><Generations><Goals><Heart Valves><Illumination><Image><In Vitro><In vivo analysis><Infection><Infectious Diseases><Infectious Disorder><Infectious Skin Diseases><Knowledge acquisition><Laboratory Research><Laser Electromagnetic><Laser Radiation><Lasers><Light><Lighting><Long-term infection><Lung><Lung Respiratory System><Malignant Neoplasms><Malignant Tumor><Mediating><Mentors><Metals><Methods><Microbial Biofilms><Miscellaneous Antibiotic><Molecular Interaction><Morphology><Mouth Diseases><Nanostructures><Nanotechnology><New Agents><Oral Cavity Disease><Oral Cavity Disorder><Oral Disease><Oral Disorder><Organ><Orthodontics><Patients><Pennsylvania><Phase><Photoradiation><Polymers><Process><Property><Public Health><Radiology><Radiology Specialty><Radiopaque Media><Removal><Reporting><Research><Research Activity><Research Proposals><Research Resources><Resistance to antibiotics><Resistant to antibiotics><Resolution><Resources><Rodent><Rodent Model><Rodentia><Rodents Mammals><S aureus><S mutans><S. aureus><S. mutans><Safety><Scientist><Shapes><Skin><Skin Diseases><Skin Diseases and Manifestations><Skin Tissue><Staph aureus><Staphylococcus aureus><Streptococcus mutans><Structure><Surface><Surgical Removal><Techniques><Testing><Therapeutic><Therapeutic Studies><Therapy Research><Thermal Ablation Therapy><Tissues><Tomodensitometry><Tooth><Tooth structure><Training><Training Programs><Transition Elements><Treatment Cost><Universities><Virulent><Wound Infection><Wound Repair><Wound models><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><anti-bacterial><anti-microbial><antibiotic drug resistance><antibiotic resistant><antimicrobial><biocompatibility><biofilm><biomaterial compatibility><cardiovascular disorder><career><career development><catscan><chemical property><chronic infection><clinical intervention><clinical therapy><colloidal nano particle><colloidal nanoparticle><computed axial tomography><computer tomography><computerized axial tomography><computerized tomography><cutaneous disease><cutaneous infection><cutaneous tissue><dermal disease><dermal disorder><design><designing><developmental><disease control><disorder control><experience><experiment><experimental research><experimental study><experiments><extracellular><flexibility><flexible><fluorescence imaging><fluorescent imaging><imaging><imaging in vivo><improved><in vivo><in vivo evaluation><in vivo imaging><in vivo testing><infected skin><infected wound><infection mouth><innovate><innovation><innovative><irradiation><light effects><malignancy><medical implant><metallicity><microbial><microorganism><model of animal><mouth disorder><multidisciplinary><nano><nano cage><nano medicinal><nano medicine><nano particle><nano tech><nano technology><nano-sized particle><nano-sized structures><nano-structures><nano-technological><nanocage><nanocrystal><nanomaterials><nanomedicinal><nanomedicine><nanoparticle><nanoshell><nanosized particle><nanotech><nanotechnological><nanotherapeutic><neoplasm/cancer><non-contrast CT><noncontrast CT><noncontrast computed tomography><novel><optoacoustic imaging><oral infection><oral infectious><oral pathogen><pathogen><persistent infection><photoacoustic imaging><photothermal therapy><physical property><plasmonics><polymer><polymeric><post-doctoral training><prevent><preventing><resection><resolutions><skills><skin disorder><skin infection><soft tissue><teeth><thermal ablation><thermal tumor ablation><time interval><tissue wound><tooth decay><transition metal><trial regimen><trial treatment><urinary bladder><wound><wound healing><wound healing models><wound recovery><wound resolution><wounding><wounds>
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JOONAS JAMSEN

UNIV OF ARKANSAS FOR MED SCIS, LITTLE ROCK, AR

Exploratory lead · 30/100
Very recent
Active award
$249,000
FY 2026

Project Title

Molecular Architecture of Oxidative Stress Induced Double Strand Break Repair

Grant Number:

5R00ES029572-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/8/2023

End Date:

2/28/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract Excess reactive oxygen and nitrogen species (RONS) from radiation, polluted air, as well as chemicals in food and water induce oxidative stress and cause direct damage to nucleotide bases. A prominent form of oxidized damage in the genome and free nucleotide pools is 8-oxoG or 8-oxo-dGTP, r...

Research Terms

<1H-Purin-6-amine><2'-deoxy-guanosine><7,8-dihydro-8-oxo-guanosine><7,8-dihydro-8-oxoguanosine><8-hydroxyguanosine><8-oxo-7,8-dihydroguanosine><8-oxo-dGTP><8-oxoG><8-oxoGuo><8-oxoguanosine><Active Oxygen><Active Sites><Address><Adenine><Aging><Air><Air Pollution><Architecture><Assay><Base Excision Repairs><Base Pairing><Behavior><Bioassay><Biological Assay><Bypass><Cancers><Catalysis><Causality><Cell Body><Cells><Chemicals><Complex><Cryo-electron Microscopy><Cryoelectron Microscopy><Crystallographies><Crystallography><DNA><DNA Base Excision Repair><DNA Damage Repair><DNA Polymerases><DNA Repair><DNA Repair Gene><DNA Repair Pathway><DNA Replication><DNA Synthesis><DNA biosynthesis><DNA lesion><DNA mutation><DNA polymerase mu><DNA repair protein><DNA-Dependent DNA Polymerases><DNA-Directed DNA Polymerase><Degenerative Neurologic Disorders><Deoxyguanosine><Deoxyribonucleic Acid><Development><Disease><Disease Progression><Disorder><Double Strand Break Repair><Electron Cryomicroscopy><Engineering / Architecture><Environment><Environmental genotoxicant><Enzymatic Biochemistry><Enzyme Gene><Enzyme Kinetics><Enzymes><Enzymology><Etiology><Exposure to><Food><Future><GTP><Genetic Change><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Genome><Genome Instability><Genome Stability><Genomic Instability><Genomic Stability><Goals><Guanosine Triphosphate><H-bond><Hydrogen Bonding><Hydrogen Oxide><Kinetics><Knowledge><Laboratories><Lead><Lesion><Link><Macromolecular Protein Complexes><Maintenance><Malignant Neoplasms><Malignant Tumor><Mediating><Methods><Mission><Molecular><Molecular Analysis><Multiprotein Complexes><Mutagenesis><Mutagenesis Molecular Biology><Mutation><NHEJ><NIEHS><National Institute of Environmental Health Sciences><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Nitrogen><Non-Homologous End Joining><Non-homologous DNA End Joining><Nonhomologous DNA End Joining><Nonhomologous End Joining><Nucleotides><O element><O2 element><Outcome><Oxidative Stress><Oxidative Stress Induction><Oxygen><Oxygen Radicals><Pb element><Phase><Pol mu><Polymerase><Population><Predisposition><Pro-Oxidants><Productivity><Proteins><Radiation><Reaction><Reactive Oxygen Species><Repair Complex><Research><Role><Structure><Susceptibility><Training><Unscheduled DNA Synthesis><Visualization><Vitamin B4><Water><Work><aging associated disease><aging associated disorders><aging related disease><aging related disorders><artemis><base><bases><cancer risk><career><causation><cryo-EM><cryoEM><cryogenic electron microscopy><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><develop therapy><developmental><disease associated with aging><disease causation><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><effective therapy><effective treatment><environmental agent><environmental mutagenesis><environmental mutagens><enzyme substrate><genome integrity><genome mutation><genomic integrity><heavy metal Pb><heavy metal lead><human disease><insight><intervention development><malignancy><mutant><natural aging><neoplasm/cancer><neurodegenerative illness><new technology><normal aging><normative aging><novel technologies><oxidative DNA damage><oxidative damage><oxidative injury><prevent><preventing><protein complex><repair><repaired><social role><targeted cancer therapy><therapy development><transversion mutation><treatment development>
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Kevin Ho-Yin Leung

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 30/100
Very recent
Active award
$249,000
FY 2026

Project Title

Large-scale artificial intelligence using radiomics, deep learning, and physics-based generative modeling to improve clinical outcomes in nuclear medicine

Grant Number:

4R00CA287045-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Cancer is the second leading cause of death in the United States where delays in diagnosis and treatment lead to increased mortality and advanced-stage disease. Developing artificial intelligence (AI) and deep learning (DL) approaches for the automatic characterization of ma...

Research Terms

<AI based><AI system><Address><Advisory Committees><Age><Anatomic Sites><Anatomic structures><Anatomy><Artificial Intelligence><Atomic Medicine><Benign><Biological><CAT scan><CT X Ray><CT Xray><CT imaging><CT scan><Cancer Patient><Cancer Prognosis><Cancer Treatment><Cancerous><Cancers><Cause of Death><Characteristics><Classification><Clinical><Clinical Data><Collaborations><Committee Members><Computed Tomography><Computer Reasoning><Computer Vision Systems><Data><Data Bases><Data Set><Databases><Decision Trees><Detection><Devices><Diagnosis><Dimensions><Discipline of Nuclear Medicine><Disease><Disorder><Early Diagnosis><Engineering><Environment><Food and Drug Administration><General Radiology><Glean><Grant><Health><Heterogeneity><High Performance Computing><Image><Knowledge><Lead><Learning><Lesion><Logistic Regressions><MR Imaging><MR Tomography><MRI><MRIs><Machine Intelligence><Machine Learning><Magnetic Resonance Imaging><Malignant><Malignant - descriptor><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Manuals><Medical><Medical Device><Medical Imaging><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mentors><Methods><Modality><Modeling><Morphology><NMR Imaging><NMR Tomography><Nuclear Magnetic Resonance Imaging><Nuclear Medicine><Outcome><PET><PET Scan><PET imaging><PETSCAN><PETT><Pathology><Patient imaging><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pb element><Phase><Physicians><Physics><Population><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Process><Prognosis><Progression-Free Survivals><Protocol><Protocols documentation><Publications><Rad.-PET><Radiography><Radiology><Radiology / Radiation Biology / Nuclear Medicine><Radiology Specialty><Reproducibility><Research><Research Resources><Resolution><Resources><Roentgen Rays><Roentgenography><Sampling><Scientific Publication><Source><Standardization><Systematics><TCIA><Task Forces><Techniques><Technology><The Cancer Imaging Archive><Tomodensitometry><Tracer><Training><USFDA><United States><United States Food and Drug Administration><Universities><Variant><Variation><Visual><X-Radiation><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><X-Ray Radiation><X-ray><Xray><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><Zeugmatography><advisory team><ages><anti-cancer therapy><artificial intelligence based><biologic><biomarker discovery><cancer imaging><cancer therapy><cancer type><cancer-directed therapy><catscan><clinical database><clinical imaging><clinical prognosis><computed axial tomography><computer tomography><computer vision><computerized axial tomography><computerized tomography><data base><deep learning><deep learning method><deep learning strategy><digital><digital data><early detection><generative models><heavy metal Pb><heavy metal lead><high-end computing><image construction><image generation><image reconstruction><image-based method><imaging><imaging biomarker><imaging in patients><imaging marker><imaging method><imaging modality><imaging on patients><imaging-based biological marker><imaging-based biomarker><imaging-based marker><improved><insight><interest><large data sets><large datasets><machine based learning><machine learning based model><machine learning model><malignancy><mortality><multilayer perceptron><neoplasm/cancer><non-contrast CT><noncontrast CT><noncontrast computed tomography><oncologic imaging><oncology imaging><patient oriented outcomes><patient population><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><predict clinical outcome><prognostic><prognostication><radiolabel><radiolabels><radiological imaging><radiomics><radiotracer><random forest><reconstruction><resolutions><response to therapy><response to treatment><sex><simulation><standardize guidelines><success><support vector machine><task analysis><therapeutic response><therapy response><tool><transfer learning><treatment response><treatment responsiveness><tumor><tumor imaging><ultrasound><uptake>
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Lilian J Shin-Cho

RESEARCH INST OF FOX CHASE CAN CTR, PHILADELPHIA, PA

Exploratory lead · 30/100
Very recent
Active award
$249,000
FY 2026

Project Title

Positive Activities for Asian American Cancer Patients and Caregivers

Grant Number:

5R00CA267678-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/13/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Asian Americans (AAs) are the fastest growing minority group in the U.S., and cancer is the leading cause of death among this group. Although AA who are diagnosed with cancer commonly report fear, distress, and depression, they have been found to utilize mental health servic...

Research Terms

<Active Follow-up><Affect><Age><American><Asian Americans><Award><Behavior><Behavioral><Cancer Control><Cancer Control Science><Cancer Patient><Cancer Treatment><Cancers><Capital><Care Givers><Caregiver well-being><Caregivers><Cause of Death><Church><Cognitive><Collaborations><Communities><Competence><Control Groups><Country><Data><Dependence><Development><Diagnosis><Disparities><Disparity><Distant><Distress><Elements><Emotional><Environment><Family Care Giver><Family Caregiver><Family member><Fear><Feeling><Friends><Fright><Goals><Home><Household><Human Resources><Individual><Individuals from minority><Individuals of minority><Intervention><Interview><Investigators><Job loss><Language><Learning><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Manpower><Mediating><Mediator><Mental Depression><Mental Health Services><Mental Hygiene Services><Mentorship><Methods><Minority Groups><Minority People><Minority Population><Minority individual><Outcome><Participant><Patients><Personal Satisfaction><Phase><Physical Function><Population><QOL><Qualitative Research><Quality of life><Randomized><Reporting><Research><Research Personnel><Research Training><Researchers><Role><Self Administered><Self Administration><Self Determination><Services><Social Responsibility><Social support><Structure><Testing><Thinking><Training><Work><acceptability and feasibility><active followup><ages><anti-cancer therapy><burden on families><burden to families><cancer care><cancer diagnosis><cancer disparity><cancer health disparity><cancer prevention><cancer therapy><cancer-directed therapy><cancer-related health disparity><care giver well-being><care giver wellbeing><caregiver wellbeing><community based participatory research><community led research><community participatory research><community partnered participatory research><compare intervention><compare to control><comparison control><comparison intervention><cooking><cost><cultural competence><culturally competent><depression><design><designing><developmental><disparity elimination><disparity in cancer><disparity in health><eliminate disparities><eliminating disparities><experience><familial burden><family burden><feasibility testing><feelings><follow up><follow-up><followed up><followup><health disparity><health literacy><health related quality of life><homes><improved><inclusion criteria><intervention design><intervention effect><malignancy><member><mental health care><neoplasm/cancer><novel><participant enrollment><participatory action research><patient enrollment><perceived stress><perception of stress><personnel><physical symptom><prototype><psychologic><psychological><randomisation><randomization><randomly assigned><self-reported stress><skills><social group><social relationships><social role><social stigma><social support network><stigma><stress perception><theories><therapy design><thoughts><treatment design><volunteer><well-being><wellbeing>
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Rachael Laura Philips

OHIO STATE UNIVERSITY, Columbus, OH

Exploratory lead · 30/100
Very recent
Active award
$249,000
FY 2026

Project Title

Genomic regulation of immune response by a STAT1 gain of function mutation

Grant Number:

4R00AI177758-02

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract The coordinated effort of the immune system in host defense is dependent upon the proper release and interpretation of different cytokine signals. Several examples of monogenic diseases targeting the JAK-STAT pathway reveal there is still a critical need to understand basic ...

Research Terms

<(IFN) α><(IFN)-α><(IFN)α><ATAC><Aberrant Chromosome><Affect><Alferon><Anti-viral Response><Autoimmune Diseases><Autoimmune Status><Autoimmunity><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Binding><Bioinformatics><Blocking Antibodies><Body Tissues><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CSIF><CSIF-10><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Cancer Treatment><Cell Body><Cell Communication and Signaling><Cell Death><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Chromatin><Chromosomal Aberrations><Chromosomal Abnormalities><Chromosomal Alterations><Chromosome Aberrations><Chromosome Alterations><Chromosome Anomalies><Chromosome abnormality><Chronic><Communities><Cytogenetic Aberrations><Cytogenetic Abnormalities><Cytokine Signal Transduction><Cytokine Signaling><Cytokine Synthesis Inhibitory Factor><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><Cytotoxic cell><Development><Development Plans><Disease><Disorder><Educational process of instructing><Educational workshop><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exhibits><Exposure to><Feedback><Frequencies><Fungus Diseases><Gene Expression><Gene Transcription><Genes><Genetic Transcription><Genomics><Goals><Grant><HPGF><Health><Hepatocyte-Stimulating Factor><Host Defense><Hybridoma Growth Factor><IFN><IFN Alpha><IFN α><IFN-Gamma><IFN-beta 2><IFN-g><IFN-α><IFN-γ><IFNB2><IFNG><IFNa><IFNα><IFNγ><IL-10><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL-6><IL10><IL10A><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><IL6 Protein><Immune><Immune Interferon><Immune response><Immune system><Immunes><Immunology><Immunomodulation><Impairment><Infection><Interferon Alfa-n3><Interferon Gamma><Interferon Type II><Interferon-α><Interferons><Interleukin 10 Precursor><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin-10><Interleukin-17><Interleukin-6><Intracellular Communication and Signaling><K lymphocyte><KI mice><Knock-in><Knock-in Mouse><LPTN><Laboratories><Leukocyte Interferon><Literature><Liver><Long-Term Effects><Lymphoblast Interferon><Lymphoblastoid Interferon><MGI-2><MS treatment><Malignant Cell><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Memory><Memory Deficit><Memory impairment><Mendelian disease><Mendelian disorder><Mendelian genetic disorder><Mentors><Mice><Mice Mammals><Modeling><Molecular><Molecular Interaction><Murine><Mus><Mycoses><Myeloid Differentiation-Inducing Protein><NIAMS><NIH><NK Cells><National Institute of Arthritis, and Musculoskeletal, and Skin Diseases><National Institutes of Health><Natural Killer Cells><Output><Pathway interactions><Patients><Phase><Plasmacytoma Growth Factor><Play><Poly I-C><Polyinosinic-Polycytidylic Acid><Position><Positioning Attribute><Production><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Research><Research Resources><Research Training><Resistance><Resources><Role><SCM-1><SCM-1a><SCM1><SCYC1><STAT1><STAT1 gene><STAT3><STAT3 gene><STAT4><STAT4 gene><STAT91><Signal Transduction><Signal Transduction Systems><Signaling><Spleen><Spleen Reticuloendothelial System><Stimulus><Subcellular Process><System><T cell response><T memory cell><T8 Cells><T8 Lymphocytes><Teaching><Technology><Teff cell><Testing><Therapeutic><Tissues><Training><Transcription><United States National Institutes of Health><Viral Burden><Viral Diseases><Viral Load><Viral Load result><Virus Diseases><Weight><Work><Workshop><Writing><XCL1><XCL1 gene><antagonism><antagonist><anti-cancer therapy><autoimmune condition><autoimmune disorder><autoimmune uveitis><autoimmunity disease><biological signal transduction><cancer cell><cancer therapy><cancer-directed therapy><career development><chromosomal defect><chromosome defect><class development><course development><course material development><cytokine><cytokine release syndrome><cytokine storm><developmental><differential expression><differentially expressed><effector T cell><epigenetically><epigenome><experience><experiment><experimental research><experimental study><experiments><fungal infection><fungus infection><gain of function><gain of function mutation><hepatic body system><hepatic organ system><host response><immune modulation><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><in vivo><insight><interferon beta 2><interferon therapy><knockin><knockin mice><lFN-Gamma><memory T lymphocyte><memory dysfunction><microbiome><monogenic disease><monogenic disorder><mouse model><multiomics><multiple omics><multiple sclerosis therapy><multiple sclerosis treatment><murine model><necrocytosis><novel><panomics><pathway><poly I:C><poly IC><poly(I:C)><resistant><response><single-gene disease><single-gene disorder><social role><tenure process><tenure track><therapeutic target><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><viral infection><virus infection><virus-induced disease><weights>
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Stephanie Momeni

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Exploratory lead · 30/100
Very recent
Active award
$248,999
FY 2026

Project Title

Novel small molecule biosynthetic gene clusters in Streptococcus mutans and virulence of dental caries

Grant Number:

5R00DE029527-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/18/2024

End Date:

4/30/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Dental caries is a global infectious disease impacting the lives of 80% of the human population. Severe early childhood caries (SECC) is of particular concern and characterized by extensive tooth decay that can dramatically affect the dental health of children under six years of age....

Research Terms

<0-11 years old><4 year old><4 years of age><5 year old><5 years of age><6 year old><6 years of age><Acids><Affect><Animal Model><Animal Models and Related Studies><Appointment><Award><Bacteria><Bacterial Model><CIS Gene><CIS protein><CIS-1 Gene><CIS-1 Protein><CISH Protein><CISH gene><Career Choice><Career Path><Caries><Child><Child Health><Child Welfare><Child Youth><Children (0-21)><Clinical><Collaborations><Common Rat Strains><Communicable Diseases><Cytokine Inducible SH2-Containing Protein><Cytokine-Inducible Inhibitor of Signaling Type 1B><Cytokine-Inducible Inhibitor of Signaling Type 1B Gene><Cytokine-Inducible SH2-Containing Protein Gene><DNA Molecular Biology><DNA mutation><Data><Dental Decay><Dental Research><Dental caries><Development><Drosophila><Drosophila genus><Economic Burden><Epidemiology><Flies><G15><G18><G18 Gene><Gene Cluster><Gene Expression><Gene Transcription><Genes><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Genome><Genotype><Health><Human><Hybrids><In Vitro><Infectious Diseases><Infectious Disorder><Ions><Journals><Knock-out><Knockout><Knowledge><LC/MS><LUCA15><Lead><Liquid Chromatography><Magazine><Maps><Microbial Biofilms><Modeling><Modern Man><Molecular Biology><Mouth microbiome><Mutagenesis><Mutagenesis Molecular Biology><Mutation><Oral health><Pathogenesis><Pb element><Phase><Phenotype><Population><Population Research><Population-based research><Population-level research><Property><Publications><Publishing><RBM5><RBM5 gene><RNA Expression><RNA Seq><RNA sequencing><RNA-Binding Motif Protein 5><RNAseq><Rat><Rats Mammals><Rattus><Recombinants><Research><Research Training><Risk><Role><S mutans><S. mutans><SOCS Gene><Scientific Publication><Streptococcus mutans><Suppressor of Cytokine Signaling><Suppressor of Cytokine Signaling Gene><Testing><Time><Transcription><Virulence><Virulent><Work><adolescent welfare><age 4><age 4 years><age 5><age 5 years><age 6><age 6 years><anti-microbial peptide><biofilm><biological adaptation to stress><butyrolactone><career aspiration><career interest><career pathway><career track><child well being><child wellbeing><clinical phenotype><clinical translation><clinically translatable><dental health><design><designing><developmental><disparity in health><early childhood><entire genome><environmental stresses><environmental stressor><epidemiologic><epidemiological><epidemiology research study><epidemiology study><epidemiology survey><fitness><five year old><five years of age><fly><four year old><four years of age><fruit fly><full genome><genome mutation><genome sequencing><health disparity><heavy metal Pb><heavy metal lead><high risk><in vivo><insight><investigate population><kids><later in life><later life><liquid chromatography mass spectrometry><metabolism measurement><metabolomics><metabonomics><microbial><model of animal><multidisciplinary><mutant><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><oral microbiome><pathogenicity gene><population investigation><population level investigation><population specific research><prevent><preventing><programs><reactioncrisis><six year old><six years of age><small molecule><social role><stress response><stressreaction><studies of populations><study of the population><study population><survey population><tandem mass spectrometry><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tooth decay><trait><transcriptome sequencing><transcriptomic sequencing><transcriptomics><virulence gene><virulent gene><whole genome><youngster>
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Gary Liu

GEORGIA INSTITUTE OF TECHNOLOGY, ATLANTA, GA

Exploratory lead · 30/100
Very recent
Active award
$248,999
FY 2026

Project Title

New siRNA therapeutics to halt diabetic kidney disease

Grant Number:

4R00DK139418-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Chronic kidney disease (CKD) is an urgent health problem in the U.S., afflicting ~15% of Americans and costing the healthcare system $120 billion/year. Despite the availability of glucose-normalizing drugs, diabetes remains the leading cause of renal failure. Current treatme...

Research Terms

<1,2-Ethanediol><2-Hydroxyethanol><Academia><Accounting><Adhesions><Adult-Onset Diabetes Mellitus><Albumins><Albuminuria><American><Attenuated><BB2><Bar Codes><Bioinformatics><Blood><Blood Reticuloendothelial System><Blood Serum><Body Tissues><Brittle Diabetes Mellitus><CD102><CD102 Antigen><CD31><CD54><CD54 Antigens><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Cholesterol><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinical><Complex><Creatinine><D-Glucose><DNA><DNA Therapy><Deoxyribonucleic Acid><Dextrose><Diabetes Mellitus><Diabetic Kidney Disease><Diabetic Nephropathy><Dihydroxyethanes><Disease><Disease Progression><Disorder><Drugs><Endothelial Cells><Endothelium><Engineering><Ethanediols><Ethylene Glycols><Exhibits><Extravasation><FDA approved><Faculty><Fibrosis><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Gene Transfer Clinical><Genes><Genetic Intervention><Glucose><Goals><Health><Health Care Costs><Health Care Systems><Health Costs><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><Human><ICAM-1><ICAM-1 Gene><ICAM-2><ICAM1><ICAM1 gene><ICAM2><ICAM2 gene><IDDM><Immune><Immunes><Immunoblotting><Immunofluorescence><Immunofluorescence Immunologic><In Vitro><Individual><Industry><Infiltration><Inflammation><Inflammatory><Insulin-Dependent Diabetes Mellitus><Intercellular Adhesion Molecule 2><Intercellular adhesion molecule 1><Intervention><Intravenous><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><Ketosis-Resistant Diabetes Mellitus><Kidney><Kidney Diseases><Kidney Failure><Kidney Insufficiency><Kidney Urinary System><Knock-out><Knockout><Laboratories><Lead><Leakage><Libraries><Lipids><Liver><Liver Cells><Lung><Lung Respiratory System><Macrophage><Maturity-Onset Diabetes Mellitus><Mediating><Medication><Medicine><Mentors><Messenger RNA><Mice><Mice Mammals><Modeling><Modern Man><Monoethylene Glycol><Murine><Mus><Mφ><NIDDM><Nephrology><Nephropathy><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Onset of illness><PECAM1><PECAM1 gene><Pb element><Pharmaceutical Preparations><Phase><Position><Positioning Attribute><Post-Transcriptional Gene Silencing><Postdoc><Postdoctoral Fellow><Property><Proteins><Public Health><RNA Interference><RNA Interference Therapy><RNA Silencing><RNA interference therapeutics><RNA interference-based therapy><RNAi><RNAi therapeutics><RNAi therapy><RNAi-based therapeutics><RNAi-based therapy><Renal Cell><Renal Disease><Renal Failure><Renal Insufficiency><Renal Tissue><Reporter><Reporting><Research Associate><Research Resources><Resources><Role><STZ><Safety><Sequence-Specific Posttranscriptional Gene Silencing><Serum><Short interfering RNA><Slow-Onset Diabetes Mellitus><Small Interfering RNA><Specific qualifier value><Specified><Spillage><Spleen><Spleen Reticuloendothelial System><Stable Diabetes Mellitus><Streptozocin><Streptozotocin><Sudden-Onset Diabetes Mellitus><T1 DM><T1 diabetes><T1D><T1DM><T2 DM><T2D><T2DM><Technology><Testing><Therapeutic><Tissues><Training><Treatment Efficacy><Tropism><Type 1 Diabetes Mellitus><Type 1 diabetes><Type 2 Diabetes Mellitus><Type 2 diabetes><Type I Diabetes Mellitus><Type II Diabetes Mellitus><Type II diabetes><United States><Upregulation><Urinalysis><Western Blotting><Western Immunoblotting><Work><Zanosar><adult onset diabetes><attenuate><attenuates><barcode><blood glucose regulation><cell sorting><chronic kidney disease><conference><convention><cost><deep sequencing><deliver short interfering RNA><deliver siRNA><deliver small interfering RNA><delivery system for siRNA><delivery system for small interfering RNA><delivery vectors for siRNA><determine efficacy><diabetes><disease onset><disorder onset><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><efficacy testing><empowerment><ethylene glycol><evaluate efficacy><examine efficacy><flow cytophotometry><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><glucose control><glucose homeostasis><glucose regulation><heavy metal Pb><heavy metal lead><hepatic body system><hepatic organ system><hypertension control><hypertension management><in vivo><insulin dependent diabetes><insulin dependent type 1><interest><intervention efficacy><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><ketosis resistant diabetes><kidney cell><kidney disorder><kidney dysfunction><kidney fibrosis><knock-down><knockdown><large data sets><large datasets><lipid based nanoparticle><lipid nanoparticle><mRNA><maturity onset diabetes><mouse model><murine model><nano particle delivery><nanoparticle delivered><nanoparticle delivery><nucleic acid delivery><post-doc><post-doctoral><post-doctoral trainee><precision medicine><precision-based medicine><prevent><preventing><prophylactic><protein blotting><recruit><renal><renal disorder><renal dysfunction><renal fibrosis><research associates><screening><screenings><short interfering RNA delivery><siRNA><siRNA delivery><siRNA therapy><siRNA-based therapeutic><siRNA-based therapy><small interfering RNA delivery><social role><summit><symposia><symposium><therapeutic efficacy><therapeutic siRNA><therapeutic small interfering RNA><therapy efficacy><type 2 DM><type I diabetes><type II DM><type one diabetes><type two diabetes><undergrad><undergraduate><undergraduate student>
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Jerzy Eisenberg-Guyot

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Exploratory lead · 30/100
Very recent
Active award
$248,999
FY 2026

Project Title

Analyzing the roles of social class and power dynamics in health disparities over the life course

Grant Number:

4R00AG081545-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2024

End Date:

2/28/2029

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Differences in health across demographic groups are large in the US, with recent declines in population life expectancy caused by elevated mortality among lower-income and less-educated people. Hazardous working conditions, like low wages and poor job control, underlie differences in mortality, self...

Research Terms

<21+ years old><Address><Adult><Adult Human><Businesses><Contracting Opportunities><Contracts><Cross-Sectional Studies><Cross-Sectional Survey><Data><Data Set><Disease Frequency Surveys><Economic Income><Economical Income><Economics><Employee><Employee Health><Employment><Goals><Health><Income><Job Location><Job Place><Job Setting><Job Site><Jobs><Life Cycle><Life Cycle Stages><Life Expectancy><Link><Longitudinal Studies><Longitudinal Surveys><Low income><Mental disorders><Mental health disorders><Methods><National Health Interview Survey><Occupations><Ownership><Persons><Phase><Policies><Population><Position><Positioning Attribute><Prevalence><Productivity><Professional Positions><Proxy><Psychiatric Disease><Psychiatric Disorder><Research><Risk><Role><Salaries><Social Class><Social Mobility><Social Power><Testing><Time><Training><Wages><Wellness Program><Work><Work Location><Work Place><Work-Site><Workplace><Worksite><adulthood><aging associated><aging related><authority><career><cross-sectional research study><design><designing><differences in health><disparity in health><economic><hazard><health data><health difference><health disparity><healthspan><healthy life span><improved><incomes><life course><long-term study><longitudinal outcome studies><longitudinal research study><mental illness><mortality><novel><panel study of income dynamics><population health><psychiatric illness><psychological disorder><social group><social role><success><theories><trend><work setting>
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Kotdaji Ha

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 30/100
Very recent
Active award
$248,999
FY 2026

Project Title

Deciphering polycystin-dependent electric signaling of primary cilia in the renal system

Grant Number:

4R00DK131361-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/2/2022

End Date:

1/31/2029

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Primary cilia are unique organelles that protrude from the cell membrane of almost all vertebrate cells. Defective primary cilia, caused by mutations in proteins required for cilia formation or signaling, can result in ciliopathies, pleiotropic diseases affecting multiple or...

Research Terms

<ADPKD><Adult Polycystic Kidney Disease><Affect><Assay><Autosomal Dominant Polycystic Kidney><Autosomal Dominant Polycystic Kidney Disease><Bioassay><Biological Assay><Biology><C-Type Lectins><CRISPR><CRISPR/Cas system><Cations><Causality><Cell Body><Cell Communication and Signaling><Cell Membrane Extensions><Cell Membrane Projections><Cell Membrane Protrusions><Cell Signaling><Cell Surface Extensions><Cell Surface Projections><Cell Surface Protrusions><Cell membrane><Cells><Characteristics><Cilia><Clustered Regularly Interspaced Short Palindromic Repeats><Complex><Cyst><Cystic kidney><Cytoplasmic Membrane><DNA mutation><Data><Development><Disease><Disorder><Dominant Polycystic Kidney Disease><Dysfunction><ESKD><ESRD><Electrophysiology><Electrophysiology (science)><End stage renal failure><End-Stage Kidney Disease><End-Stage Renal Disease><Epithelial Cells><Etiology><Foundations><Functional disorder><Genetic Change><Genetic defect><Genetic mutation><Glean><Goals><Human><Impairment><Incentives><Integral Membrane Protein><Intracellular Communication and Signaling><Intracellular Second Messenger><Intrinsic Membrane Protein><Ion Channel><Ionic Channels><Ions><Kidney><Kidney Cyst><Kidney Diseases><Kidney Tubules><Kidney Urinary System><Knowledge><Lead><Mammalian Cell><Measures><Membrane><Membrane Channels><Mendelian disease><Mendelian disorder><Mendelian genetic disorder><Mentors><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Mutation><Nephropathy><Neurophysiology / Electrophysiology><Organ><Organelles><Organoids><Pathogenicity><Pathway interactions><Patients><Pb element><Phase><Phenotype><Physiologic><Physiological><Physiology><Physiopathology><Plasma Membrane><Play><Postdoc><Postdoctoral Fellow><Preparation><Proteins><Publications><Publishing><Regulation><Renal Cyst><Renal Disease><Renal tubule structure><Research Associate><Role><Scientific Publication><Second Messenger Systems><Second Messengers><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Stimulus><Structure><Supervision><Surface><System><Techniques><Testing><Time><Training><Transmembrane Protein><Transmembrane Protein Gene><Tubular><Tubular formation><Universities><Variant><Variation><Washington><Work><biological signal transduction><career><causation><ciliopathy><clinical significance><clinically significant><developmental><disease causation><disease causing variant><disease-causing allele><disease-causing mutation><effective therapy><effective treatment><electrophysiological><experiment><experimental research><experimental study><experiments><genome mutation><heavy metal Pb><heavy metal lead><human disease><insight><kidney disorder><membrane structure><molecular phenotype><monogenic disease><monogenic disorder><mutant><patch clamp><pathogenic allele><pathogenic variant><pathophysiology><pathway><plasmalemma><post-doc><post-doctoral><post-doctoral trainee><preparations><prevent><preventing><regenerative approach><regenerative strategy><regenerative technique><renal><renal disorder><renal epithelium><renal tubule><research associates><signal transduction second messengers><single-gene disease><single-gene disorder><social role><tool>
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Anna Swift Young

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 30/100
Very recent
Active award
$248,942
FY 2026

Project Title

Mapping the cosmetic chemical exposome and its role in female fertility

Grant Number:

4R00ES036289-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Infertility affects about 15% of couples, and ovulatory dysfunction is a primary cause with unclear etiology. Studies have found that certain chemicals are reproductive toxicants and impair female fertility. However, these studies are limited to a small number of known environmenta...

Research Terms

<Acceleration><Affect><Algorithms><Applications Grants><Assisted Reproduction Technology><Assisted Reproductive Technology><Automobile Driving><Biological><Biological Markers><Biotransformation><Birth><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><California><Cannot achieve a pregnancy><Categories><Causality><Chemical Exposure><Chemicals><Clinical><Clinical Treatment><Complex><Complex Mixtures><Cosmetics><Couples><Data Bases><Databases><Development><Diagnosis><Difficulty conceiving><Disease><Disorder><Encapsulated><Endocrine><Endocrine Disrupter><Endocrine Disrupting Chemicals><Endocrine Disruptors><Endocrine disrupting agent><Environment><Environmental Factor><Environmental Risk Factor><Etiology><Evaluation><Exposome studies><Exposure to><Fecundability><Fecundity><Female Genital System><Female infertility><Fertility><Fertility Study><Fingerprint><Follicular Fluid><Future><General Population><General Public><Gestation><Grant Proposals><Gynecologic><HRMS><Habits><Health><Human><Impairment><Infertility><Intervention><Laboratories><Link><Liquor Folliculi><Live Birth><Maps><Massachusetts><Measurement><Measures><Metabolic Biotransformation><Metabolic Pathway><Modern Man><Oocytes><Organ><Outcome><Ovarian><Ovarian Follicle Antral Fluid><Ovary><Ovocytes><Parturition><Pathway interactions><Patient Self-Report><Patients><Phase><Poison><Polycystic Ovarian Disease><Polycystic Ovarian Syndrome><Polycystic Ovary Syndrome><Pregnancy><Preventative intervention><R-Series Research Projects><R01 Mechanism><R01 Program><Registries><Reproductive Health><Research><Research Grants><Research Project Grants><Research Projects><Research Resources><Research Specimen><Resources><Risk Factors><Role><Sampling><Sclerocystic Ovarian Degeneration><Sclerocystic Ovary Syndrome><Self-Report><Sister><Source><Specimen><Survey Instrument><Surveys><Time><Toxic Chemical><Toxic Substance><Urine><Woman><Women's cohort><assisted reproduction><assistive reproductive technology><bio-markers><biologic><biologic marker><biomarker><causation><classification algorithm><clinical intervention><clinical therapy><co-exposures><co-occurring exposure><cohort><cohort in women><cohort on women><combined exposure><complex exposure><concurrent exposure><cosmetic product><data base><developmental><diagnostic biomarker><diagnostic marker><disease causation><driving><egg quality><egg retrieval><endocrine disrupting compound><environmental chemical><environmental risk><experience><exposome><exposome related research><exposome research><exposome science><exposomics><exposure mixture><exposure reduction interventions><female cohort><female fertility><female outcomes><female reproductive body system><female reproductive health><female reproductive organ system><female reproductive system><fertility cessation><fertility loss><gynecologic body system><gynecologic organ system><high resolution mass spec><high resolution mass spectrometry><high resolution mass spectroscopy><high-resolution mass spectrometer><implantation><improved><infertile><infertility in women><innovate><innovation><innovative><intervention for prevention><machine learned algorithm><machine learning algorithm><machine learning based algorithm><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><mixed exposure><novel><oocyte quality><oocyte retrieval><outcomes among females><outcomes among women><outcomes in females><outcomes in women><ovarian dysfunction><ovarian reserve><ovulatory dysfunction><pathway><personal care products><polycystic ovary><polycystic ovary disease><polycystic ovary disorder><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><prevention intervention><preventional intervention strategy><preventive intervention><programs><reproductive><reproductive health among females><reproductive health among women><reproductive health in females><reproductive health in women><reproductive organ><reproductive outcome><risk sharing><simultaneous exposures><social role><toxic compound><toxicant><trial regimen><trial treatment><unable to bear children><web site><website><women's outcomes><women's reproductive health>
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Anupama Jha

YALE UNIVERSITY, NEW HAVEN, CT

Exploratory lead · 30/100
Very recent
Active award
$248,823
FY 2026

Project Title

Integrative models of nuclear DNA organization

Grant Number:

4R00HG013663-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2029

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract The human genome organization influences gene regulation. Aberrant nuclear structures observed in cancer and conservation of common features of genome organization, such as A/B compartments, topologically associated domains, and loops across mammalian evolution, further hint ...

Research Terms

<2-dimensional><3-D><3-Dimensional><3D><ATAC sequencing><ATAC-seq><ATACseq><Advisory Committees><Alternate Splicing><Alternative RNA Splicing><Alternative Splicing><Architecture><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Base Sequence><Bioassay><Biochemical><Biological Assay><Biological Function><Biological Process><Biology><Body Tissues><Cancers><Cell Nucleus><Chromatin><Clinical><Connectionist Models><ConvNet><DNA><Data><Deoxyribonucleic Acid><Disease><Disorder><Engineering / Architecture><Environment><Evolution><Foundations><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Genes><Genetic Diversity><Genetic Transcription><Genetic Variation><Genome><Genomics><Goals><Health><Hi-C><Human><Human Genome><Interpretable ML><Interpretable machine learning><Investigators><Joints><Learning><Learning Skill><Machine Learning><Malignant Neoplasms><Malignant Tumor><Maps><Measures><Mentors><Methods><Modeling><Modern Man><Multiomic Data><NGS Method><NGS system><Neural Network Models><Neural Network Simulation><Non-Polyadenylated RNA><Nuclear><Nuclear Structure><Nucleotide Sequence><Nucleus><Output><Perceptrons><Phase><Position><Positioning Attribute><Post-Transcriptional Control><Post-Transcriptional Regulation><Postdoc><Postdoctoral Fellow><Process><RNA><RNA Expression><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Regulation><Research><Research Associate><Research Personnel><Research Resources><Research Training><Researchers><Resources><Ribonucleic Acid><Role><Scientist><Shapes><Task Forces><Tissues><Training><Transcript><Transcription><Transcriptional Control><Transcriptional Regulation><Translating><Translations><Universities><Variant><Variation><Washington><Work><advisory team><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><bridge program><career development><computer based prediction><convolutional network><convolutional neural nets><convolutional neural network><deep learning based model><deep learning model><design><designing><developmental disease><developmental disorder><epigenetic regulation><explainable ML><explainable machine learning><gene locus><genetic locus><genome scale><genome-wide><genomewide><genomic location><genomic locus><human DNA><human tissue><human whole genome><insight><learning activity><learning method><learning strategies><learning strategy><machine based learning><machine learning based method><machine learning based model><machine learning method><machine learning methodologies><machine learning model><malignancy><meter><multiple omic data><neoplasm/cancer><next gen sequencing><next generation sequencing><nextgen sequencing><novel><nucleic acid sequence><open source><post-doc><post-doctoral><post-doctoral trainee><post-transcriptional gene regulation><pre-trained transformer><predictive modeling><preservation><programs><research associates><social role><structural determinants><structural factors><three dimensional><tool><transcriptome sequencing><transcriptomic sequencing><transcriptomics><transformer architecture><transformer based model><transformer model><translation><two-dimensional>
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Andrea Romanos-Nanclares

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 30/100
Very recent
Active award
$248,810
FY 2026

Project Title

A multi-omics approach to evaluate the role of chronic inflammation in breast cancer development

Grant Number:

4R00CA286891-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The long-term objective of this project is to develop Dr. Romanos-Nanclares’s capacity to conduct studies that integrate dietary and lifestyle factors with multi-omics data and traditional biomarkers to better understand the biological pathways underlying the etiology of aggressive f...

Research Terms

<Address><Adherence><Assay><Award><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Bioassay><Bioinformatics><Biological><Biological Assay><Biological Markers><Blood Plasma><Blood Sample><Blood specimen><Breast Cancer><Breast Cancer Prevention><Breast Cancer Risk Factor><Breast Neoplasms><Breast Tissue><Breast Tumors><C-reactive protein><CD 120a Antigen><CD120a Antigens><Cancer Cause><Cancer Etiology><Cancers><Causality><Chemopreventive><Chemopreventive Agent><Cholesterol Esters><Cholesteryl Esters><Chronic><Data><Data Sources><Development><Diagnostic><Diet><Dietary Epidemiology><Dietary Factors><Dietary Practices><Dimensions><Disease><Disorder><Dysfunction><ER Negative><ER Positive><ER+><Endocrine Therapy><Environment><Epidemiology><Estrogen Receptors><Estrogen receptor negative><Estrogen receptor positive><Etiology><Food><Foundations><Functional disorder><Future><Gene Expression><Goals><HPGF><Hepatocyte-Stimulating Factor><Hormonal Therapy><Hospitals><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Immune response><Inflammation><Inflammatory><Interleukin-6><Investigators><Knowledge acquisition><Life Style><Lifestyle><Long-term cohort><Longitudinal cohort><MGI-2><Malignant Breast Neoplasm><Malignant Neoplasms><Malignant Tumor><Mammary Cancer><Mammary Gland Parenchyma><Mammary Gland Tissue><Mammary Neoplasms><Measures><Mentors><Methodology><Methods><Multiomic Data><Myeloid Differentiation-Inducing Protein><NIH><National Institutes of Health><Nurses' Health Study><Nutrition Research><Nutritional Study><Obesity><Pathogenicity><Pathology><Pathway interactions><Pattern><Physiopathology><Plasma><Plasma Serum><Plasmacytoma Growth Factor><Play><Position><Positioning Attribute><Preventative strategy><Prevention strategy><Preventive strategy><Prognosis><Proliferating><Proteins><Proteins, specific or class, C-reactive><Proteome><Proteomics><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Design><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Research Specimen><Researchers><Resources><Reticuloendothelial System, Serum, Plasma><Risk><Risk Factors><Role><Sample Size><Solid><Specimen><Strategic Planning><Study Type><System><TNF Receptor p55><TNF-sR55><TNF-α receptor><TNFAR><TNFR p60><TNFR, 55-kD><TNFR, 60-kD><TNFR-I><TNFR1><TNFR55><TNFR60><TNFRSF1A><TNFRSF1A Receptor><TNFRSF1A gene><TNFalpha receptor><TNFα receptor><Techniques><Technology><Testing><Training><Tumor Necrosis Factor Receptor 1><Tumor Necrosis Factor Receptor 55><Tumor Subtype><Tumor Tissue><United States National Institutes of Health><Upregulation><Woman><Work><acylcarnitine><adiposity><advanced analytics><anti-carcinogenic><bio-markers><biologic><biologic marker><biological specimen archives><biomarker><biosample archive><biospecimen archive><breast cancer risk><breast pathology><cancer epidemiology><cancer prevention><career><causation><chemoprevention agent><corpulence><design><designing><developmental><dietary><dietary approach><dietary pattern><diets><disease causation><epidemiologic><epidemiological><experience><high dimensionality><high risk><hormone therapy><host response><immune system response><immunoresponse><indexing><innovate><innovation><innovative><insight><interferon beta 2><life-style factor><lifestyle factors><malignancy><malignant breast tumor><mammary cancer prevention><mammary tumor><mammary tumor prevention><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><multiomics><multiple omic data><multiple omics><neoplasm/cancer><novel><nutritional approach><nutritional epidemiology><panomics><pathophysiology><pathway><post-doctoral training><precision nutrition><prevent><prevent breast cancer><preventing><prospective><proteomic signature><receptor expression><research vision><skills><social role><specimen archive><study design><therapeutic target><transcriptomics><tumor><tumor necrosis factor alpha receptor><tumor necrosis factor receptor 1A><tumor necrosis factor α receptor>
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Emily L Newman

TUFTS UNIVERSITY BOSTON, BOSTON, MA

Exploratory lead · 30/100
Very recent
Active award
$248,784
FY 2026

Project Title

Amygdala Circuit Mechanisms for Stress-escalated Aggression

Grant Number:

5R00MH133869-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY (See instructions): Pathway to Independence: The R00 phase of this project will support my independent research program examining the mechanistic underpinnings of trauma-induced aggression and violence in the Tufts University School of Medicine Department of Neuroscience. Project S...

Research Terms

<ACTH-Releasing Factor><Address><Adopted><Affect><Aggression><Aggressive behavior><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><CRF-41><Calcium><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Clinical><Corticoliberin><Corticotropin-Releasing Factor><Corticotropin-Releasing Factor-41><Corticotropin-Releasing Hormone><Corticotropin-Releasing Hormone-41><Development><Emotional><Fear><Fright><Home environment><Hostility><Image><Individual><Instruction><Interpersonal Violence><Intracellular Communication and Signaling><Link><Mediator><Mice><Mice Mammals><Modeling><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neuropeptides><Neurosciences><Optics><PTSD><Pathologic><Pathway interactions><Phase><Phenotype><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Postdoc><Postdoctoral Fellow><Posttraumatic Neuroses><Reaction><Research><Research Associate><Role><Signal Transduction><Signal Transduction Systems><Signaling><Sleep disturbances><Stress><Syndrome><Training><Translational Regulation><Trauma><Universities><Violence><Work><aberrant sleep><amygdaloid nuclear complex><biological signal transduction><cell imaging><cellular imaging><corticotropin releasing hormone><developmental><disrupted sleep><disturbed sleep><effective therapy><effective treatment><emotion regulation><emotional regulation><experiment><experimental research><experimental study><experiments><exposure to trauma><fighting><imaging><impaired sleep><interpersonal trauma><irregular sleep><medical college><medical schools><neural circuit><neural circuitry><neurocircuitry><neuronal><novel><optical><optogenetics><pathway><post-doc><post-doctoral><post-doctoral trainee><post-doctoral training><post-trauma stress disorder><posttrauma stress disorder><programs><recruit><research associates><school of medicine><sleep disruption><sleep dysregulation><sleep/wake disruption><sleep/wake disturbance><social><social role><stressor><synaptic circuit><synaptic circuitry><trauma exposure><traumatic neurosis><violent><violent behavior>
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N Apurva Ratan Murty

GEORGIA INSTITUTE OF TECHNOLOGY, ATLANTA, GA

Exploratory lead · 30/100
Very recent
Active award
$248,752
FY 2026

Project Title

Towards a computationally precise characterization of the human ventral visual pathway

Grant Number:

5R00EY032603-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2021

End Date:

3/31/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract: Humans are extraordinarily visual animals, allocating a third of their cortex just to seeing what is in front of them. Visual recognition is supported by a series of hierarchically organized brain regions known collectively as the ventral visual cortex (VVC). Despite extens...

Research Terms

<Acquired brain injury><Address><Algorithms><Animals><Area><Behavior><Brain><Brain Injuries><Brain Nervous System><Brain region><Categories><Cognition><Computer Models><Computerized Models><Computing Methodologies><Corpus Striatum><Corpus striatum structure><Data><Data Bases><Databases><Development><Disease><Disorder><Encapsulated><Encephalon><Evolution><Eye><Eyeball><Face><Functional MRI><Functional Magnetic Resonance Imaging><Goals><Human><Image><Impairment><Individual><Location><Maps><Mentors><Methods><Modeling><Modern Man><Monkeys><Network-based><Neurosciences><Pattern><Perception><Performance><Phase><Population><Position><Positioning Attribute><Reading><Recovery><Research><Resolution><Rest><Series><Sight><Social Functioning><Stimulus><Striate Body><Striatum><Supervision><System><Testing><Text><Vision><Visual><Visual Cortex><Visual Pathways><Visual Perception><Work><analytical method><brain damage><brain-injured><cognitive ability><cohort><computational methodology><computational methods><computational modeling><computational models><computer based method><computer based models><computer methods><computerized modeling><computing method><data base><data quality><deep learning based neural network><deep learning neural network><deep neural net><deep neural network><design><designing><developmental><experiment><experimental research><experimental study><experiments><extrastriate><fMRI><faces><facial><function socially><functioning social><fusiform face area><imaging><insight><interest><neural><neural imaging><neuro-imaging><neuro-prosthetic><neuroimaging><neurological imaging><neuroprosthesis><neuroprosthetic><neurosurgery><object recognition><public health relevance><resolutions><response><screening><screenings><striatal><super high resolution><superresolution><theories><ultra high resolution><ventral pathway><ventral processing stream><ventral stream><ventral visual pathway><ventral visual processing stream><ventral visual stream><vision development><visual cortical><visual development><visual function><visual information><visual process><visual processing><visual stimulus><visual system development>
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Kara Ann Johnson

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 30/100
Very recent
Active award
$248,333
FY 2026

Project Title

Basal Ganglia Network Neurophysiology of Depression in Parkinson’s Disease

Grant Number:

4R00NS137249-02

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/5/2025

End Date:

1/31/2029

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Depression is a debilitating nonmotor symptom of Parkinson’s disease (PD) that affects approximately 40% of patients and contributes to worsened quality of life. Despite its prevalence and burden, depression in PD is often inadequately treated with current therapies. Growing evidence indicates depre...

Research Terms

<Affect><Award><Basal Ganglia><Basal Nuclei><Brain><Brain Mapping><Brain Nervous System><Brain region><Cell Communication and Signaling><Cell Signaling><Chronic><Clinical Research><Clinical Study><Computer Models><Computerized Models><Data><Deep Brain Stimulation><Devices><Drugs><Dysfunction><Electrodes><Emotional Depression><Encephalon><Environment><Evaluation><Exhibits><Faculty><Frequencies><Functional disorder><Ganglia><Globus Pallidus><Goals><Human><Individual><Intracellular Communication and Signaling><Lead><Link><Machine Learning><Maps><Medication><Mental Depression><Mental disorders><Mental health disorders><Methods><Modeling><Modern Man><Motor><Nervous System Diseases><Nervous System Disorder><Neural Ganglion><Neurologic Disorders><Neurological Disorders><Nucleus Subthalamicus><Paralysis Agitans><Parkinson><Parkinson Disease><Pathologic><Patients><Pb element><Pharmaceutical Preparations><Phase><Physiologic><Physiological><Physiopathology><Position><Positioning Attribute><Prevalence><Primary Parkinsonism><Psychiatric Disease><Psychiatric Disorder><Psychiatry><QOL><QOL improvement><Quality of life><Reaction><Research><Role><Secure><Signal Transduction><Signal Transduction Systems><Signaling><Source><Structure of subthalamic nucleus><Subthalamic Nucleus><Techniques><Testing><Therapeutic><Training><Work><activity marker><biological signal transduction><candidate identification><career development><cohort><computational modeling><computational models><computer based models><computerized modeling><depression><depression symptom><depressive><depressive symptoms><disability><drug/agent><effective therapy><effective treatment><heavy metal Pb><heavy metal lead><improved><improvements in QOL><improvements in quality of life><machine based learning><mental illness><motor symptom><multi-modality><multimodality><network models><neural><neural control><neural imaging><neural regulation><neuro-imaging><neuroimaging><neuroimaging biomarker><neuroimaging marker><neurological disease><neurological imaging><neuromodulation><neuromodulatory><neurophysiological><neurophysiology><neuropsychiatric><neuropsychiatric symptom><neuropsychiatry><neuroregulation><non-motor symptom><nonmotor symptom><novel><pallidum><pathophysiology><programs><prospective><psychiatric illness><psychological disorder><quality of life improvement><social role>
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Harim Tavares Dos Santos

STATE UNIVERSITY OF NEW YORK AT BUFFALO, AMHERST, NY

Exploratory lead · 30/100
Very recent
Active award
$245,440
FY 2026

Project Title

The Role of Tufts Cells in Salivary Gland Immunity

Grant Number:

5R00DE032363-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2024

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Tuft cells are rare cholinergic chemosensory epithelial cells capable of producing an unusual spectrum of biological effector molecules, such as interleukins, eicosanoids and neurotransmitters. Previous studies have shown that tuft cells are capable of triggering immune responses in ...

Research Terms

<Ablation><Active Follow-up><Affect><Area><Autoimmune Diseases><B Cell Differentiation Factor I><B cell growth factor><B cell growth factor 2><B-Cell Differentiation Factor-1><B-Cell Growth Factor-1><B-Cell Growth Factor-I><B-Cell Growth Factor-II><B-Cell Proliferating Factor><B-Cell Stimulating Factor><B-Cell Stimulating Factor-1><B-Cell Stimulation Factor-1><B-Cell Stimulatory Factor-1><BCDF-1><BCGF><BCGF-1><BCGF-II><BCGF2><BCSF 1><BSF-1><BSF1><Basal Transcription Factor><Basal transcription factor genes><Binding><Binetrakin><Biological><Body Tissues><Buccal Cavity><Buccal Cavity Head and Neck><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Cavitas Oris><Cell Body><Cell Communication and Signaling><Cell Components><Cell Function><Cell Lineage><Cell Physiology><Cell Process><Cell Signaling><Cell Structure><Cells><Cellular Function><Cellular Immune Function><Cellular Physiology><Cellular Process><Cellular Structures><Cellular biology><Chronic><Common Rat Strains><Coupled><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><DNA Molecular Biology><Detection><Development><Disease><Disorder><Dryness><Eicosanoids><Electron Microscopy><Eo-CSF><Eosinophil Differentiation Factor><Epithelial Cells><Epithelium><Exhibits><Exocrine Glands><Exposure to><Family><Follow-Up Studies><Foundations><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><General Transcription Factor Gene><General Transcription Factors><Generations><Genes><Gut Epithelium><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Homeo Boxes><Homeobox><Host Defense><Human><IL-13><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL-17E><IL-4><IL-5><IL13><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><IL4 Protein><IgA enhancing factor><Immune><Immune response><Immune signaling><Immunes><Immunity><Immunomodulation><Impairment><Inducer Cells><Inducer T-Lymphocytes><Inflammation><Inflammatory><Innate Immune Response><Innate Immunity><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin 5 Precursor><Interleukin-13><Interleukin-17><Interleukin-4><Interleukin-4 Precursor><Interleukin-5><Interleukins><Intestinal><Intestines><Intracellular Communication and Signaling><Investigation><Investigators><LTRPC5><Laboratories><Lecithinases><Lipopolysaccharides><Literature><Long Transient Receptor Potential Channel 5><Lymphocyte Stimulatory Factor 1><Lymphocytic Infiltrate><MCGF-2><MLSN1- and TRP-Related Gene 1><MTR1><Mast Cell Growth Factor-2><Mediating><Mentors><Mentorship><Mice><Mice Mammals><Microscopic><Microscopy><Microvilli><Microvillus><Minor Salivary Glands><Minor salivary gland structure><Modern Man><Modernization><Molecular Biology><Molecular Immunology><Molecular Interaction><Mouth><Murine><Mus><Native Immunity><Natural Immunity><Nerve Transmitter Substances><Neurotransmitters><Non-Specific Immunity><Nonspecific Immunity><Oral cavity><Organ><Pathogenesis><Pathway interactions><Patients><Phase><Phospholipase><Play><Principal Investigator><Produce saliva><Proteins><Rat><Rats Mammals><Rattus><Receptor Protein><Receptor Signaling><Research><Research Personnel><Research Specimen><Researchers><Resolution><Respiratory Epithelium><Role><Saliva production><Salivary Gland Diseases><Salivary Glands><Salivary excretion><Salivation><Sensory><Shapes><Sicca Syndrome><Signal Transduction><Signal Transduction Systems><Signaling><Sjogren's Disease><Sjogren's Syndrome><Sjogrens><Sjögren Syndrome><Source><Specimen><Structure><Structure of respiratory epithelium><Subcellular Process><Submandibular gland><Submaxillary Gland><T cell replacing factor><T-Cell Growth Factor 2><T-Cell Replacing Factor><TRPM5><TRPM5 gene><Taste Buds><Techniques><Technology><Time><Tissues><Training><Transcription Factor Proto-Oncogene><Transcription factor genes><Transient Receptor Potential Cation Channel, Subfamily M, Member 5><Work><active followup><adaptive immune response><adaptive immunity><airway epithelium><alpha-gustducin><autoimmune condition><autoimmune disorder><autoimmunity disease><biologic><biological signal transduction><bowel><cell biology><cell type><cellular microvillus><cholinergic><cytokine><defense response><design><designing><developmental><experiment><experimental research><experimental study><experiments><follow up><follow-up><follow-up research study><follow-up survey><followed up><followup><gastrointestinal epithelium><host response><immune function><immune modulation><immune regulation><immune system function><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><in vivo><in vivo Model><innate immune function><insight><interleukin-17E><member><mouse model><murine model><neutralizing antibody><novel><pathogen><pathway><physiological defense response><programs><receptor><receptor-mediated signaling><resolutions><respiratory tract epithelium><response><saliva secretion><salivary disorder><salivary gland disorder><salivary production><salivary secretion><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell analysis><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><study with follow-up><taste receptor><therapeutic target><transcription factor><xerodermosteosis><α-gustducin>
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Salman Ehtesham Qasim

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Exploratory lead · 30/100
Very recent
Active award
$244,829
FY 2026

Project Title

The computational and neural mechanisms linking decision-making and memory in humans

Grant Number:

5R00MH132873-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/11/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT DESCRIPTION The PI for this R00 proposal, Dr. Salman Qasim, is transitioning to a tenure-track faculty position in the Department of Neurosurgery at Rutgers Robert Wood Johnson Medical School. The original research proposed remains unaltered. Briefly, this project seeks to answer decision-ma...

Research Terms

<Address><Affect><Ammon Horn><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Assay><Automobile Driving><Behavior><Behavioral><Bioassay><Biological Assay><Biological Markers><Brain><Brain Nervous System><Cell Communication and Signaling><Cell Signaling><Cognition><Complex><Computer Models><Computerized Models><Cornu Ammonis><Decision Making><Disparate><Dysfunction><Electrodes><Electrophysiology><Electrophysiology (science)><Encephalon><Event><Exhibits><Faculty><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Hippocampus><Hour><Human><Image><Impairment><Intracellular Communication and Signaling><Intractable Epilepsy><Investigators><Knowledge><Learning><Link><Measures><Medial><Mediating><Memory><Memory Loss><Mental Depression><Mental disorders><Mental health disorders><Mentorship><Mesencephalon><Mid-brain><Midbrain><Midbrain structure><Modeling><Modern Man><Nerve Cells><Nerve Unit><Neural Cell><Neurobiology><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Outcome><Patients><Performance><Phase><Physiopathology><Play><Position><Positioning Attribute><Predisposition><Process><Psychiatric Disease><Psychiatric Disorder><Psychological reinforcement><R-Series Research Projects><R01 Mechanism><R01 Program><Refractory epilepsy><Reinforcement><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Reversal Learning><Rewards><Signal Transduction><Signal Transduction Systems><Signaling><Sleep><Stimulus><Study models><Susceptibility><Techniques><Testing><Training><Wood><Wood material><addiction><addictive disorder><amygdaloid nuclear complex><bio-markers><biologic marker><biological signal transduction><biomarker><computational basis><computational modeling><computational models><computer based models><computerized modeling><depression><driving><drug-resistant epilepsy><electrophysiological><epilepsy monitoring><epilepsy participant><epilepsy patient><epilepsy recording><epilepsy subject><epilepsy tracking><epilepsy volunteer><epileptic monitoring><epileptic patient><epileptic recording><epileptic subject><epileptiform monitoring><epileptiform recording><epileptiform tracking><epileptogenic monitoring><fMRI><frontal cortex><frontal lobe><healthy volunteer><hippocampal><human subject><imaging><medical college><medical schools><member><memory consolidation><memory decline><memory process><memory processing><memory recognition><mental illness><negative affect><negative affectivity><neural><neural mechanism><neurobiological><neuromechanism><neuronal><neurosurgery><pathophysiology><patients with epilepsy><psychiatric illness><psychological disorder><recruit><reward processing><ruminate><rumination><ruminative><school of medicine><seizure detection><seizure monitoring><seizure recording><seizure tracking><skills><spatial and temporal><spatial temporal><spatiotemporal><temporal measurement><temporal resolution><tenure process><tenure track><theories><time interval><time measurement>
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Thomas L Clarke

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Exploratory lead · 30/100
Very recent
Active award
$236,709
FY 2026

Project Title

Identifying chromatin factors essential for DNA repair using a novel high-throughput screening methodology

Grant Number:

5R00ES034443-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/5/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY (See instructions): Mammalian cells are continually exposed to environmental toxicants including UV-radiation and various sources of ionizing radiation (IR) threatening genomic integrity, leading to an increased risk of cancer and neurodegenerative disease. Given our constant exposu...

Research Terms

<ATAC sequencing><ATAC-seq><ATACseq><ATM Protein><ATM Serine/Threonine Protein Kinase><ATM kinase><ATM protein kinase><Abscission><Actinic Rays><Address><Age related pathologies><Architecture><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Ataxia Telangiectasia Mutated><Ataxia Telangiectasia Protein><Ataxia-Telangiectasia-Mutated protein kinase><Award><BRCA1><BRCA1 Gene Product><BRCA1 Protein><BRCA1 gene><Bioassay><Biochemical><Biochemistry><Biologic Models><Biological Assay><Biological Chemistry><Biological Models><Breast Cancer 1 Gene><Breast Cancer 1 Gene Product><Breast Cancer Type 1 Susceptibility Gene><Breast Cancer Type 1 Susceptibility Protein><Breast-Ovarian Cancer Protein><Cell Body><Cells><ChIP assay><Chromatin><Chromatin Structure><Complex><Coupled><DNA><DNA Damage><DNA Damage Repair><DNA Double Strand Break><DNA Helicases><DNA Injury><DNA Molecular Biology><DNA Repair><DNA Unwinding Proteins><DNA unwinding enzyme><Data><Degenerative Neurologic Disorders><Deoxyribonucleic Acid><Development><Double Strand Break Repair><Early Onset Gene Breast Cancer 1><Early Onset Protein Breast Cancer 1><Engineering / Architecture><Environment><Environmental Toxin><Enzyme Gene><Enzymes><Event><Excision><Exposure to><Expression Library><Extirpation><Genes><Genetic><Genetics-Mutagenesis><Genome Instability><Genome Stability><Genomic Instability><Genomic Stability><Goals><Hereditary Breast Cancer 1><High Throughput Assay><Immune Precipitation><Immunofluorescence><Immunofluorescence Immunologic><Immunoprecipitation><Innovative Therapy><Instruction><Ionizing Electromagnetic Radiation><Ionizing radiation><Kinases><Link><Maintenance><Mammalian Cell><Maps><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediator><Mentors><Methodology><Model System><Modification><Molecular Biology><Mutagenesis><Mutagenesis Molecular Biology><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Outcome><Pancreas Ductal Adenocarcinoma><Pancreatic Ductal Adenocarcinoma><Pathway interactions><Patients><Phase><Phosphotransferase Gene><Phosphotransferases><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Process><Prognosis><Protein Biochemistry><Protein Modification><Protein/Amino Acid Biochemistry><Proteins><Publications><RNF53><Radiation-Ionizing Total><Regulation><Removal><Research><Resolution><Role><Scientific Publication><Series><Site><Source><Surgical Removal><Techniques><Therapeutic Intervention><Toxic Environmental Agents><Toxic Environmental Substances><Transphosphorylases><UV light><UV radiation><UV rays><Ultraviolet Rays><Unscheduled DNA Synthesis><Validation><Work><age associated pathologies><age dependent pathologies><age induced pathologies><aging associated pathologies><aging dependent pathologies><aging induced pathologies><aging pathologies><aging related pathologies><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><ataxia telangiectasia mutated protein><brca 1 gene><cDNA Expression><cDNA Library><cancer risk><chromatin immunoprecipitation><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><developmental><environmental toxicant><experiment><experimental research><experimental study><experiments><genome integrity><genomic integrity><helicase><high throughput screening><homologous recombination><in vivo><intervention therapy><ionizing output><neurodegenerative illness><novel><nuclease><pathway><phospho-proteomics><phosphoproteomics><protein complex><protein protein interaction><recruit><repair><repaired><resection><resistance to therapy><resistant to therapy><resolutions><response><response to therapy><response to treatment><screening><screenings><social role><therapeutic resistance><therapeutic response><therapy resistant><therapy response><treatment resistance><treatment response><treatment responsiveness><ultra violet light><ultra violet radiation><ultra violet rays><ultraviolet light><ultraviolet radiation><validations>
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Marielena Sosa

UNIVERSITY OF COLORADO, Boulder, CO

Exploratory lead · 30/100
Very recent
Active award
$225,176
FY 2026

Project Title

Neural circuit dynamics of spatial reward memory

Grant Number:

4R00MH135993-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/3/2024

End Date:

4/30/2029

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary / Abstract Our strongest memories often stem from our most rewarding experiences, allowing us to learn what features of experience predict reward and to use these predictions in the future. The ability to remember rewarding spatial locations, such as food sources, is crucial for surv...

Research Terms

<2-dimensional><2-photon><Address><Amentia><Ammon Horn><Animal Structures><Animals><Area><Behavior><Behavioral><Brain><Brain Nervous System><Brain region><Business-Friendly Atmosphere><Calcium><Cell Body><Cells><Chemical Dependence><Code><Coding System><Cognitive><Cognitive Retention Disorders><Common Rat Strains><Communication><Computer Models><Computerized Models><Cornu Ammonis><Data><Decision Making><Dementia><Deterioration><Disease><Disorder><Dissociation><Drug Addiction><Drug Dependence><Drug Dependency><Electrophysiology><Electrophysiology (science)><Encephalon><Entorhinal Area><Environment><Event><Fire - disasters><Fires><Food><Foundations><Future><Goals><Head><Hippocampus><Human><Image><Knowledge><Lead><Learning><Location><Maps><Medial><Memory><Memory Disorders><Mental disorders><Mental health disorders><Mentors><Mentorship><Mice><Mice Mammals><Modeling><Modern Man><Monitor><Movement><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Pb element><Periodicals><Population><Population Dynamics><Process><Property><Psychiatric Disease><Psychiatric Disorder><Psychological reinforcement><Rat><Rats Mammals><Rattus><Reinforcement><Research><Rewards><Rodent><Rodentia><Rodents Mammals><Science><Shapes><Source><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Structure><Techniques><Technology><Testing><Training><Universities><Update><Work><body movement><business-friendly environment><career><cell type><cognitive change><collaborative atmosphere><collaborative environment><computational modeling><computational models><computer based models><computerized modeling><density><design><designing><electrophysiological><enthusiastic atmosphere><enthusiastic environment><entorhinal cortex><experience><experiment><experimental research><experimental study><experiments><fire><flexibility><flexible><heavy metal Pb><heavy metal lead><hippocampal><imaging><imaging in mice><imaging studies for mice><imaging studies in mice><innovate><innovation><innovative><insight><interactive atmosphere><interactive environment><interdisciplinary atmosphere><interdisciplinary environment><member><memory process><memory processing><mental illness><mice imaging><motor control><murine imaging><neural><neural circuit><neural circuitry><neurocircuitry><neuronal><peer-group atmosphere><peer-group environment><perceptual stimulus><periodic><periodical><physicochemical phenomena related to the senses><psychiatric illness><psychological disorder><recruit><sensory stimulus><skills><statistical analysis><statistics><stem><supportive atmosphere><supportive environment><synaptic circuit><synaptic circuitry><tool><two-dimensional><two-photon><virtual>
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Lina Marcela Carmona

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Exploratory lead · 30/100
Very recent
Active award
$224,101
FY 2026

Project Title

Dissection of Cell Type Specific Contributions to Motor Learning Circuits

Grant Number:

5R00NS127857-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2022

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Abstract Whether riding your bike down a narrow path or reaching for your favorite cookie in a small box, many of our daily actions require skilled and accurate movements. However, to achieve proficiency, these motor skills must first be learned through the process of motor learning. Much wo...

Research Terms

<ASD><Address><Affect><Animals><Area><Assay><Autism><Autistic Disorder><Behavior><Bioassay><Biological Assay><Brain><Brain Mapping><Brain Nervous System><Brain region><CAGH44><Calcium><Cell Body><Cell Nucleus><Cells><Classification><Complement><Complement Proteins><Complex><DNA Molecular Biology><Data Analyses><Data Analysis><Disease><Disorder><Dissection><Early Infantile Autism><Encephalon><Environment><Exhibits><FOXP2><FOXP2 gene><Feedback><Forelimb><Forkhead Box P2><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Transcription><Generations><Genetic Transcription><Goals><Human><Immediate-Early Genes><In vivo two-photon calcium imaging><Infantile Autism><Investigators><Kanner's Syndrome><Learning><Learning Skill><Life><Maps><Medulla Spinalis><Mentors><Modern Man><Molecular><Molecular Biology><Motor><Motor Cortex><Motor Skills><Movement><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurosciences><Nucleus><Paralysis Agitans><Parkinson><Parkinson Disease><Pattern><Phase><Phenotype><Population><Population Heterogeneity><Position><Positioning Attribute><Primary Parkinsonism><Process><Proxy><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Reporting><Research Personnel><Researchers><Rest><Role><Skeletal Muscle><Sorting><Spinal Column><Spinal Cord><Spine><System><Systematics><TNRC10><Thalamic structure><Thalamus><Thinking><Training><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Trinucleotide Repeat-Containing Gene 10><Universities><Vertebral column><Voluntary Muscle><Work><analyze gene expression><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><backbone><body movement><cell imaging><cell type><cellular imaging><complementation><data interpretation><diverse populations><gene expression analysis><gene expression assay><heterogeneous population><imaging approach><imaging based approach><imaging in vivo><in vivo><in vivo calcium imaging><in vivo imaging><locomotor learning><motor ability><motor disease><motor disorder><motor dysfunction><motor learning><motor skill learning><neural><neuronal><new approaches><novel approaches><novel strategies><novel strategy><optogenetics><perceptual motor learning><population diversity><recruit><response><skills><social role><success><thalamic><thoughts><transcriptional profiling><transcriptome sequencing><transcriptomic sequencing><transcriptomics>
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Nan Xu

UNIV OF MARYLAND, COLLEGE PARK, COLLEGE PARK, MD

Exploratory lead · 30/100
Very recent
Active award
$224,100
FY 2026

Project Title

Time-varying spatiotemporal causal interactions in the functional brain networks

Grant Number:

5R00NS123113-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This proposal describes a five-year career development program to prepare the candidate, Dr. Nan Xu, for a career as independent investigator at a major academic research institute, with the expertise of modeling dynamics of brain causal system to provide novel insights into the basic pathophysiolog...

Research Terms

<AD dementia><Address><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Animal Experiments><Animal Model><Animal Models and Related Studies><Biological Markers><Biomedical Engineering><Blood Vessels><Brain><Brain Concussion><Brain Diseases><Brain Disorders><Brain Nervous System><Brain imaging><Brain region><Cell Communication and Signaling><Cell Signaling><Cerebral Concussion><Clinical><Clinical Research><Clinical Study><Cognitive><Commotio Cerebri><Communication><Commuting><Data><Development><Doctor of Philosophy><Dysfunction><Encephalon><Encephalon Diseases><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Human><Image Analyses><Image Analysis><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Investigators><Length><Math Models><Measures><Medical Rehabilitation><Mentors><Methodology><Methods><Modeling><Modern Man><Multimodal Imaging><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic Disorders><Neurological Disorders><Neurology><Neurons><Neurosciences><Pathologic><Pathology><Pathway interactions><Patients><Pattern><Performance><Ph.D.><PhD><Phase><Physiopathology><Play><Post-Concussion Symptoms><Post-Concussion Syndrome><Post-Concussive Symptoms><Post-Concussive Syndrome><Postdoc><Postdoctoral Fellow><Primary Senile Degenerative Dementia><Program Development><Rehabilitation><Rehabilitation therapy><Research Associate><Research Institute><Research Personnel><Researchers><Rest><Rodent><Rodentia><Rodents Mammals><Role><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Slide><Symptoms><Syndrome><System><Techniques><Testing><Therapeutic><Time><Training><Translating><Uncertainty><Universities><Variant><Variation><Vestibular><Vestibular System Impairment><Vestibular defect><Vestibular dysfunction><Vestibular problems><Visual Motion><Work><algorithm development><animal experiment><bio-engineered><bio-engineers><bio-markers><bioengineering><biologic marker><biological engineering><biological signal transduction><biomarker><blood oxygen level dependent><blood oxygenation level dependent><brain visualization><career><career development><clinical phenotype><clinical practice><clinical training><cognitive neuroscience><concussion><concussive><developmental><doubt><experiment><experimental animal><experimental animals><experimental research><experimental study><experiments><fMRI><hemodynamics><image evaluation><image interpretation><image translation><imaging biomarker><imaging marker><imaging-based biological marker><imaging-based biomarker><imaging-based marker><innovate><innovation><innovative><insight><machine learning based model><machine learning model><mathematic model><mathematical model><mathematical modeling><method development><model of animal><motion sensitivity><multi-modal imaging><multi-modality><multi-modality imaging><multimodality><multimodality imaging><multisensory><neurological disease><neuronal><neurophysiological><neurophysiology><novel><pathophysiology><pathway><patient response><patient specific response><post-doc><post-doctoral><post-doctoral trainee><primary degenerative dementia><rehab therapy><rehabilitative><rehabilitative therapy><research associates><response><responsive patient><senile dementia of the Alzheimer type><social role><spatial and temporal><spatial temporal><spatiotemporal><vascular><vestibular deficit><vestibular impairment><vestibular system><vestibular system dysfunction><visual-vestibular><visuo-vestibular>
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Jialiang Wang

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Exploratory lead · 30/100
Very recent
Active award
$217,607
FY 2026

Project Title

Comprehensive investigation of SP7 during the osteoblast-to-osteocyte transition

Grant Number:

5R00AR081897-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Many pathologic or disease conditions can now be ascribed to disrupted osteocyte functions. However, a limited number of osteocyte-enriched genes have been studied in bone disease. Our previous work focused on the transcription factor SP7 and its role in regulating osteocyte...

Research Terms

<Acceleration><Address><Affect><Applications Grants><Autoregulation><Award><Basal Transcription Factor><Basal transcription factor genes><Bioinformatics><Biology><Bone Development><Bone Diseases><Bone Formation><Bone Resorption><Brain><Brain Nervous System><Brittle bone disorder><Causality><Cell Body><Cell Culture Techniques><Cell Membrane Extensions><Cell Membrane Projections><Cell Membrane Protrusions><Cell Surface Extensions><Cell Surface Projections><Cell Surface Protrusions><Cells><Communication><Complex><DNA mutation><Data><Dendrites><Development><Disease><Disorder><Encephalon><Ensure><Etiology><Faculty><Fragilitas Ossium><Future><GWA study><GWAS><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Goals><Grant><Grant Proposals><Homeostasis><Human><Human Characteristics><Human Nature><In Vitro><Intermediary Metabolism><Investigation><Investigators><Knowledge><Laser Electromagnetic><Laser Radiation><Lasers><Link><Mentorship><Metabolic Processes><Metabolism><Methods><Mice><Mice Mammals><Microdissection><Modeling><Modern Man><Molecular><Murine><Mus><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neuropeptide Tyrosine><Neurosciences Research><Osteoblasts><Osteoclastic Bone Loss><Osteocytes><Osteogenesis><Osteogenesis Imperfect><Osteogenesis Imperfecta><Osteoporosis><Pathologic><Pathway interactions><Patients><Pattern><Phase><Phenotype><Physiological Homeostasis><Position><Positioning Attribute><Process><Publications><RNA Expression><Regulation><Regulatory Element><Research Personnel><Researchers><Role><Scientific Publication><Signal Pathway><Training><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transgenic Mice><Variant><Variation><Work><bone><bone disorder><bone health><bone tissue formation><brittle bone disease><career><causation><cell culture><cell cultures><cell type><developmental><disease causation><gene function><gene regulatory network><genome mutation><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><global gene expression><global transcription profile><in vitro testing><in vivo><innovate><innovation><innovative><interdisciplinary collaboration><mouse model><murine model><neuronal><neuropeptide Y><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><osteoblast cell differentiation><osteoblast differentiation><osteoblastic differentiation><pathway><programs><repurposing><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skeletal><skeletal abnormality><skeletal disease><skeletal disorder><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tenure process><tenure track><transcription factor><transcriptome><transcriptome profiling><transcriptomic profiling><transcriptomics><transdisciplinary collaboration><whole genome association analysis><whole genome association study>
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Samantha Schildroth

UNIVERSITY OF NEW ENGLAND, BIDDEFORD, ME

Exploratory lead · 30/100
Very recent
Active award
$163,856
FY 2026

Project Title

A Prospective Study of Per-and Polyfluoroalkyl Substance (PFAS) Mixtures and Pregnancy Outcomes in the Study of Environment, Lifestyle, and Fibroids

Grant Number:

4R00ES036288-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/10/2026

End Date:

3/31/2029

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Per- and polyfluoroalkyl substances (PFAS) are known endocrine disrupting chemicals (EDCs), and exposure to PFAS has been associated with adverse pregnancy outcomes, including spontaneous abortion (SAB), preterm birth (PTB), and small for gestational age (SGA) births. However, less is known about 1...

Research Terms

<Accounting><Active Follow-up><Address><Adverse effects><Affect><Amino Acids><Animals><Award><Biological><Biological Markers><Birth><Blood Plasma><Caucasian Females><Caucasian Women><Causality><Chemicals><Child Health><Chronologic Fetal Maturity><Clinic Visits><Data><Endocrine><Endocrine Disrupter><Endocrine Disrupting Chemicals><Endocrine Disruptors><Endocrine disrupting agent><Endocrine disruption><Endocrine system><Endocrine/Metabolic Organ System><Enrollment><Environment><Environmental Exposure><Epidemiological data><Epidemiology><Epidemiology data><Etiology><Exposure to><Fetal Age><Fibroid><Fibroid Neoplasm><Fibroid Tumor><Fibromyoma><Funding><Future><Gestation><Gestational Age><Goals><Health Care Costs><Health Care Systems><Health Costs><Hormonal><Hormonal System><Individual><Industrial Product><Infant><Investigators><Joints><Knowledge><Leiomyomatous Neoplasm><Leiomyomatous Tumor><Life Style><Lifestyle><Literature><Measures><Mediating><Mediation><Mediator><Metabolic Pathway><Metabolic/Endocrine Body System><Methods><Miscarriage><NIEHS><National Institute of Environmental Health Sciences><Negotiating><Negotiation><Outcome><PFAS><Participant><Parturition><Pathway interactions><Perinatal><Perinatal Epidemiology><Peripartum><Phase><Plasma><Plasma Serum><Play><Poly-fluoroalkyl substances><Pregnancy><Pregnancy Outcome><Premature Birth><Prematurely delivering><Preterm Birth><Prospective Studies><Prospective cohort><Prospective, cohort study><Psychosocial Factor><Questionnaires><Research><Research Personnel><Researchers><Reticuloendothelial System, Serum, Plasma><Risk Factors><Role><Sample Size><Sampling><Small for Gestational Age Infant><Societies><Spontaneous abortion><Structure><Toxic effect><Toxicities><Training><Visit><White Females><White Women><Woman><Women's study><Work><active followup><adverse pregnancy outcome><aminoacid><before conception><bio-markers><biologic><biologic marker><biomarker><black female><black women><career><causation><childbearing age><cohort><consumer product><disease causation><ecological toxicology><endocrine disrupting><endocrine disrupting compound><endocrine gland/system><enroll><environmental chemical><environmental toxicology><epidemiologic><epidemiologic data><epidemiological><experience><exposed human population><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fat metabolism><female study><fertile age><follow up><follow-up><followed up><followup><hormone metabolism><human exposure><lipid metabolism><metabolism measurement><metabolomics><metabonomics><novel><pathway><perceived stress><perception of stress><perfluorinated alkyl substances><perfluoroalkyl substances><perfluoroalkylated substances><polyfluorinated alkyl substances><polyfluoroalkyl substances><postpartum health><preconception><premature childbirth><premature delivery><preterm delivery><prior to conception><prospective><prospective research study><prospective survey><psychosocial variables><public health intervention><recruit><reproductive><reproductive age><reproductive years><self-reported stress><small for gestational age><social role><stress perception><study among females><study among women><study in females><study in women><study on females><study on women><study within women><substance use><substance using><toxicant>
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Michael D. Green

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 30/100
Recent
Active award
Career award
$84,581
FY 2026

Project Title

Assessing the Impact of Patient-Provider Interactions on the Cardiovascular and Cognitive Health of Aging Adults

Grant Number:

4K00AG088695-03

Activity Code:

K00

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2024

End Date:

2/28/2030

Project Abstract

The adverse effects of poor treatment in healthcare settings on cognitive impairment are poorly understood, particularly among aging Americans. My F99 research established an association between these experiences and adverse cardiovascular events. Cardiovascular events are themselves known risk fact...

Research Terms

<21+ years old><AD and related dementia><AD related dementia><ADRD><Address><Adherence><Adult><Adult Human><Adverse effects><Affect><Age><Aging><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Amentia><American><Award><Behavior><Cardiac infarction><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complex><Continuity of Care><Continuity of Patient Care><Continuum of Care><Data><Data Analyses><Data Analysis><Dementia><Diagnosis><Disturbance in cognition><Event><Face><Foundations><Goals><Health><Health Care><Health Priorities><Health and Retirement Study><Health system><Healthy diet><Heart><Heart Vascular><Hypertension><Impaired cognition><Insurance Coverage><Insurance Status><Interdisciplinary Research><Interdisciplinary Study><Intervention><Investigators><K-Awards><K-Series Research Career Programs><Knowledge><Leadership><Life Cycle><Life Cycle Stages><Measures><Medical><Mentors><Mission><Modeling><Multidisciplinary Collaboration><Multidisciplinary Research><Myocardial Infarct><Myocardial Infarction><Obesity><Outcome><Patients><Pattern><Persons><Phase><Policies><Postdoc><Postdoctoral Fellow><Public Health Schools><QOC><Quality of Care><R-Series Research Projects><R01 Mechanism><R01 Program><Recommendation><Reporting><Research><Research Associate><Research Career Program><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Training><Researchers><Risk><Risk Factors><Role><Scientist><Shapes><Smoking><Societies><Statistical Methods><Structure><Survival Analyses><Survival Analysis><System><Testing><Time><Training><Training Programs><Trust><United States><Universities><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Work><adiposity><adulthood><aged><ages><balanced diet><barrier to care><barrier to health care><barrier to treatment><cardiac infarct><cardiovascular health><cardiovascular risk><cardiovascular risk factor><career><circulatory system><clinical risk><cognitive dysfunction><cognitive loss><coronary attack><coronary infarct><coronary infarction><corpulence><cost><data interpretation><dementia risk><design><designing><experience><faces><facial><falls><good diet><health and care delivery><health care delivery><health care quality><health care settings><health data><health delivery systems><health services delivery><heart attack><heart infarct><heart infarction><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><insight><investigate longitudinal><later in life><later life><life course><longitudinal investigation><longitudinal research><malleable risk><methods to study multiple-level influences><mid life><mid-life><middle age><middle aged><midlife><modifiable risk><multi-level analysis><multi-level model><multilevel analysis><multilevel model><multilevel modeling><multimorbidity><multiple chronic conditions><novel><obstacle to care><obstacle to health care><older adult><older adulthood><patient clinician engagement><patient clinician interaction><patient clinician relationship><patient doctor engagement><patient doctor interaction><patient doctor relationship><patient physician engagement><patient physician interaction><patient physician relationship><patient provider engagement><patient provider interaction><patient provider relationship><patient-clinician communication><patient-doctor communication><patient-provider communication><poor health outcome><post-doc><post-doctoral><post-doctoral trainee><pre-doc><pre-doctoral><reduced health outcome><research associates><risk factor for dementia><risk for dementia><risk for stroke><risk of stroke><skills><social role><statistic methods><stressor><stroke risk><stroke-like challenge><stroke-like condition><stroke-like disorder><stroke-like outcome><stroke-like symptoms><stroke-like syndrome><study longitudinal><survey longitudinal><worse health outcome>
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Ramiah Donesha Jacks

OHIO STATE UNIVERSITY, Columbus, OH

Exploratory lead · 22/100
Recent
Active award
$249,001
FY 2026

Project Title

Regulation and Maintenance of Adipose Tissue T cells

Grant Number:

4R00DK136934-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2029

Project Abstract

Adipose tissue (AT) is an active metabolic organ that contains a network of immune cells whose crosstalk regulates adipose tissue homeostasis. In response to obesity, these immune cells can become activated, expand, and secrete adipokines and pro-inflammatory cytokines that modify local and systemic...

Research Terms

<Ablation><Adipose tissue><Adult-Onset Diabetes Mellitus><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antigen-Presenting Cells><Autoregulation><Award><Bioinformatics><Biopsy><Blood><Blood Reticuloendothelial System><CD11c><CD3><CD3 Antigens><CD3 Complex><CD3 molecule><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CD8><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CD8B><CD8B1><CD8B1 gene><Cell Body><Cell Communication and Signaling><Cell Cycle Kinetics><Cell Function><Cell Kinetics><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Chronic><Class I Genes><Data><Development><Diabetes Mellitus><Disease><Disorder><Fats><Fatty Tissue><Fatty acid glycerol esters><Foundations><Frequencies><GI microbiota><Gastrointestinal microbiota><Germ-Free><Goals><High Fat Diet><Homeostasis><Human><ITGAX><ITGAX gene><Immune><Immunes><Immunomodulation><In Vitro><Infiltration><Inflammation><Inflammatory><Insulin Resistance><Intermediary Metabolism><Intracellular Communication and Signaling><Ketosis-Resistant Diabetes Mellitus><Knowledge><LYT3><Leanness><Lymphoid><MHC Class I><MHC Class I Genes><Macrophage><Maintenance><Maturity-Onset Diabetes Mellitus><Mediating><Memory><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Processes><Metabolic dysfunction><Metabolism><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Mφ><NIDDM><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><OKT3 antigen><Obesity><Ontology><Organ><Phase><Phenotype><Physiological Homeostasis><Play><Population><Position><Positioning Attribute><Regulation><Regulatory T-Lymphocyte><Research><Research Training><Role><Signal Transduction><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Spleen><Spleen Reticuloendothelial System><Stable Diabetes Mellitus><Subcellular Process><T cell response><T-Cell Activation><T-Cell Proliferation><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Subsets><T2 DM><T2D><T2DM><T3 Antigens><T3 Complex><T3 molecule><T4 Cells><T4 Lymphocytes><T8 Cells><T8 Lymphocytes><Testing><Thesaurismosis><Thinness><Time><Tissue Expansion><Training><Translational Research><Translational Science><Treg><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Work><accessory cell><activate T cells><adipocytokines><adipokines><adipose><adiposity><adult onset diabetes><biological signal transduction><career development><corpulence><cytokine><developmental><diabetes><diet-associated obesity><diet-induced obesity><diet-related obesity><enteric microbial community><enteric microbiota><experiment><experimental research><experimental study><experiments><feeding><gastrointestinal microbial flora><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiota><gut microbiotic><gut microflora><immune modulation><immune regulation><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><improved><in vivo><inflammatory environment><inflammatory milieu><insulin resistant><insulin sensitivity><insulin signaling><insulin tolerance><intestinal flora><intestinal microbiota><intestinal microflora><intestinal tract microflora><ketosis resistant diabetes><maturity onset diabetes><metabolism disorder><mouse model><murine model><novel><nutrient metabolism><obesity development><programs><recruit><regulatory T-cells><response><social role><thymus derived lymphocyte><translation research><translational investigation><type 2 DM><type II DM><type two diabetes><white adipose tissue><yellow adipose tissue>
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Kristen Addie McLaurin

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Neurocognitive Impairments Resulting from Adolescent Prescription Opioid Use Disorder: Longitudinal Impact, Neural Mechanisms, and Comorbidities

Grant Number:

5R00DA056288-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT The goals of the proposed K99 career training plan include: 1) gaining expertise and research experience in substance use disorders (SUD), addictive processes, and opioid pharmacology; 2) mastering stereotaxic sur- geries, adeno-associated virus gene delivery, and in vivo fi...

Research Terms

<12-20 years old><21+ years old><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adeno-Associated Viruses><Adolescence><Adolescent><Adolescent Youth><Adolescent and Young Adult><Adult><Adult Human><Advisory Committees><Age Years><Agonist><Biosensor><Brain><Brain Nervous System><Cell Body><Cells><Chronic><Clinical><Common Rat Strains><Communicable Diseases><Control Animal><DREADDs><Dependence><Dependoparvovirus><Dependovirus><Development><Developmental Process><Dihydrohydroxycodeinone><Dopamine><Dose><Dysfunction><Encephalon><Environment><Episodic memory><Evaluation><Experimental Designs><Exposure to><Faculty><Female><Fiber><Foundations><Functional disorder><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><Gene Delivery><Goals><HIV><HIV Infections><HIV viral infection><HIV virus infection><HIV-1><HIV-1 infection><HIV-I><HIV1><Hour><Human><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Virus-1><Human Immunodeficiency Viruses><Human immunodeficiency virus 1><Hydrogen Oxide><Hydroxytyramine><IQ Deficit><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Infectious Diseases><Infectious Disorder><Institution><Intake><International><LAV-HTLV-III><Laboratories><Lymphadenopathy-Associated Virus><Mentors><Modeling><Modern Man><Muscarinic Agents><Muscarinics><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Neurocognitive><Neurocognitive Deficit><Operative Procedures><Operative Surgical Procedures><Opiates><Opioid><Oral><Overdose><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><Pharmacology><Phase><Photometry><Physiopathology><Prefrontal Cortex><Process><Public Health><Rat><Rats Mammals><Rattus><Research><Role><Roxicodone><SAMHSA><Saline><Saline Solution><Scientist><South Carolina><Strategic Planning><Substance Abuse and Mental Health Services Administration><Substance Use Disorder><Surgical><Surgical Interventions><Surgical Procedure><Synapses><Synaptic><System><Task Forces><Testing><Training><United States Substance Abuse and Mental Health Services Administration><Universities><Ventral Tegmental Area><Viral Gene Products><Viral Gene Proteins><Viral Proteins><Virus-HIV><Water><adeno associated virus group><adolescence (12-20)><adult youth><adulthood><advisory team><biological sensor><biological sex><biological systems><career><career development><co-morbid><co-morbidity><cognitive process><comorbidity><critical developmental period><designer receptors exclusively activated by designer drugs><developmental><dopamine system><experience><experiment><experimental research><experimental study><experiments><exposure route><high risk group><high risk individual><high risk people><high risk population><human immunodeficiency virus infection><in vivo><infected with HIV><infected with human immunodeficiency virus><intelligence quotient deficit><juvenile><juvenile human><licit opioid><longitudinal design><longitudinal experimental design><longitudinal research design><longitudinal study design><male><neural mechanism><neurocognitive decline><neurocognitive impairment><neuromechanism><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><opiate abuse><opiate crisis><opiate drug abuse><opiate medication><opiate use disorder><opioid abuse><opioid crisis><opioid drug abuse><opioid epidemic><opioid medication><opioid use disorder><oxycodone self-administration><pathophysiology><postnatal><pre-clinical><preclinical><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><self-administer oxycodone><skills><social role><substance use><substance use and disorder><substance using><surgery><sustained attention><synapse><therapeutic target><ventral tegmentum><virus protein><young adult><young adult age><young adulthood><♀><♂>
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Chengyi Tu

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Tachycardia-induced Metabolic Remodeling Drives Cardiac Dysfunction

Grant Number:

4R00HL164962-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/16/2026

End Date:

1/31/2029

Project Abstract

Tachycardia, or abnormally fast heart rate, is an important risk factor for cardiovascular morbidity and mortality. Prolonged tachycardia is known to induce cardiomyopathy in patients who have no prior structural heart diseases. Moreover, transient tachycardia, frequently observed in heart failure p...

Research Terms

<3-D><3-Dimensional><3-Phosphoglyceraldehyde><3-phosphoglycerate><3D><ATP-3-phospho-D-glycerate 1-phosphotransferase><Abnormal heart structure><Acceleration><Address><Adrenergic beta-Antagonists><Adrenergic beta-Blockers><Advisory Committees><Affect><Animals><Arrhythmia><Autoregulation><Binding><Biology><Biomedical Engineering><Biopsy><CRISPR interference><CRISPR-dCas9-mediated repression><CRISPR/dCas9 interference><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRi><Calcium><Canine Species><Canis familiaris><Cardiac><Cardiac Arrhythmia><Cardiac Chronotropism><Cardiac Diseases><Cardiac Disorders><Cardiac Electrophysiologic Techniques><Cardiac Electrophysiological Diagnostics><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiomyopathies><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cells><Ch'i><Chemicals><Clustered Regularly Interspaced Short Palindromic Repeats interference><Coupled><Critical Paths><Critical Pathways><Custom><D-Glucose><Data><Data Engineering><Development><Dextrose><Dogs><Dogs Mammals><Dysfunction><Enzyme Gene><Enzymes><Event><Fatty Acid Metabolism Pathway><Functional disorder><Future><G-Proteins><GAPD><GTP-Binding Proteins><GTP-Regulatory Proteins><Gene Inactivation><Gene Silencing><Genes><Genetic><Glucose><Glyceraldehyde 3-Phosphate><Glyceraldehyde-3-Phosphate Dehydrogenases><Glyceraldehydephosphate Dehydrogenase><Glycolysis><Goals><Guanine Nucleotide Coupling Protein><Guanine Nucleotide Regulatory Proteins><Heart><Heart Arrhythmias><Heart Diseases><Heart Muscle Cells><Heart Rate><Heart Vascular><Heart failure><Heart myocyte><History><Homeostasis><Human Engineering><Impairment><In Vitro><Investigators><Knowledge><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mentors><Metabolic><Metabolic Diseases><Metabolic Disorder><Modeling><Molecular><Molecular Interaction><Morbidity><Myocardial Diseases><Myocardial Disorder><Myocardial depression><Myocardial dysfunction><Myocardiopathies><Myoglobin><Outcome><Oxidative Stress><Pathology><Pathway interactions><Patients><Phase><Phenotype><Phosphoglyceraldehyde Dehydrogenase><Phosphoglycerate Kinase><Physiologic><Physiological><Physiological Homeostasis><Physiology><Physiopathology><Play><Prognosis><Protein Cleavage><Protein Subunits><Proteins><Proteolysis><Qi><RNA Seq><RNA sequencing><RNAseq><Recording of previous events><Recovery><Regulation><Research><Research Personnel><Researchers><Risk Factors><Role><Sampling><Signal Pathway><Sum><System><Tachyarrhythmias><Tachycardia><Task Forces><Technology><Therapeutic><Therapeutic Intervention><Thesaurismosis><Tissue Engineering><Tissue Model><Training><Treatment Failure><Triosephosphate Dehydrogenase><Validation><Ventricular Dysfunction><advisory team><analysis pipeline><beta blocker><beta-Adrenergic Blocking Agents><beta-Adrenergic Receptor Blockaders><bio-engineered><bio-engineers><bioengineered tissue><bioengineering><biological engineering><canine><canine animal model><canine model><cardiac dysfunction><cardiac electrophysiology><cardiac failure><cardiac function><cardiac tissue engineering><cardiomyocyte><cardiovascular risk><cardiovascular risk factor><circulatory system><customs><design><designing><developmental><dog model><domestic dog><engineered heart tissue><engineered tissue><experience><fatty acid metabolism><feasibility testing><function of the heart><global gene expression><global transcription profile><glyceraldehyde phosphate><glycerate 3-phosphate><heart disorder><heart dysfunction><heart electrophysiology><heart function><histories><human data><iPS><iPS biology><iPSC><iPSC biology><iPSCs><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell biology><inducible pluripotent cell><inducible pluripotent stem cell><intervention therapy><metabolic profile><metabolism disorder><metabolism measurement><metabolomics><metabonomics><mortality><multiomics><multiple omics><myocardium disease><myocardium disorder><novel><panomics><pathophysiology><pathway><progenitor biology><progenitor cell biology><repressing CRISPR-dCas9 system><skills><small molecular inhibitor><small molecule inhibitor><social role><stem and progenitor biology><stem cell biology><structural cardiac abnormality><structural cardiac anomaly><structural cardiac defect><structural heart condition><structural heart defect><structural heart disease><tachyrhythmia><therapy failure><three dimensional><transcriptional silencing><transcriptome><transcriptome profiling><transcriptome sequencing><transcriptomic profiling><transcriptomic sequencing><transcriptomics><validations>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Kendra D Sims

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Community Empowerment, Vascular Risk, and ADRD Disparities: Translating Research to Public Policy

Grant Number:

4R00AG083121-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

2/28/2029

Project Abstract

By 2050, racial disparities will persist among the projected 11 million adults with Alzheimer’s Disease and Related Dementias (AD/ADRD). Prior research links factors to AD/ADRD, highlighting the need for policy solutions to mitigate the racially-patterned cardiovascular disease (CVD) burden that acc...

Research Terms

<21+ years old><AD and related dementia><AD related dementia><AD risk><AD risk factor><ADRD><Acceleration><Adult><Adult Human><Alzheimer risk factor><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><American><Area><Award><Black><Black race><Blood Vessels><Boston><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Censuses><Characteristics><Clinical><Cognitive><Cohort Studies><Collaborations><Communities><Community Surveys><County><Data><Data Science><Decrease disparity><Depressed mood><Deterioration><Development><Disease><Disorder><Disparities><Disparity><Economic Factors><Economical Factors><Economics><Ensure><Event><Faculty><Foundations><Future><Goals><Health><Health Care Costs><Health Costs><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Health Policy><Health and Retirement Study><Heart Vascular><Housing><Incidence><Infrastructure><Institution><Intervention><Investigators><Investments><Joints><Knowledge><Link><Lower disparity><Machine Learning><Mediating><Mediator><Medicare><Medicare claim><Mentors><Mentorship><Modeling><Neighborhoods><Pattern><Phase><Policies><Population><Population Attributable Risks><Position><Positioning Attribute><Prevalence><Prevention><Public Health><Public Health Schools><Public Policy><Race><Races><Reasons for Geographic And Racial Differences in Stroke><Relative Risks><Research><Research Personnel><Research Resources><Researchers><Resources><Retirement><Risk><Risk Estimate><Risk Factors><Role><Sampling><Science><Social Environment><Stroke Belt><Title 18><Training><Translating><Universities><Variant><Variation><adulthood><alzheimer risk><attributable fraction><beneficiary><black/white disparity><burden of disease><burden of illness><cardiovascular disease epidemiology><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder epidemiology><cardiovascular disorder risk><cardiovascular effects><cardiovascular epidemiology><circulatory system><cohort><cohort research study><cohort survey><community empowerment><community engagement><community factor><community intervention><community level disadvantage><community level intervention><community-based intervention><community-level factor><dementia risk><demographics><depressed><developmental><disadvantaged community><disease burden><disparities in race><disparity due to race><disparity reduction><economic><empowerment><engagement with communities><health care policy><health insurance for disabled><high risk><high risk group><high risk individual><high risk people><high risk population><inequality due to race><inequity due to race><innovate><innovation><innovative><machine based learning><mitigate disparity><mortality><neighborhood barrier><neighborhood disadvantage><neighborhood-level barrier><neighborhood-level disadvantage><older adult><older adulthood><policy implication><prevent><preventing><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial origin><racially unequal><reduce disparity><reduction in disparity><residence><residential building><residential site><retirements><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><sadness><scale up><skills><social><social climate><social context><social engagement><social involvement><social participation><social role><socio-economic><socio-economically><socioeconomically><socioeconomics><socioenvironment><socioenvironmental><success><vascular>
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Hao Li

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Determining how neurotensin mediates valence processing and compulsive cocaine seeking

Grant Number:

5R00DA055111-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT A hallmark of substance use disorders is continued drug use despite profound adverse consequences. While studies in rodents have suggested that leveraging both positive and negative valence processing can affect this compulsive pattern of reward-seeking behavior in conflict ...

Research Terms

<Adaptive Behaviors><Affect><Amino Acids><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Award><Behavior><Behavioral><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Chemical Dependence><Circulatory Collapse><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cocaine><Cocaine Addiction><Cocaine Dependence><Code><Coding System><Computer Vision Systems><Conflict><Conflict (Psychology)><Control Groups><Cues><Data><Decision Making><Disease><Disorder><Dissociation><Drug Addiction><Drug Dependence><Drug Dependency><Drug usage><Drugs><Dysfunction><E-learning><Electrophysiology><Electrophysiology (science)><Faculty><Functional disorder><Genes><Glean><Glutamates><Human><Impairment><Infusion><Infusion procedures><Intake><Intracellular Communication and Signaling><L-Glutamate><Learning><Machine Learning><Mediating><Medication><Mice><Mice Mammals><Modern Man><Murine><Mus><NT1-R protein><NTR-1 protein><Negative Valence><Nerve Cells><Nerve Unit><Neural Cell><Neural Pathways><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Neurotensin><Nucleus><Nucleus Accumbens><Paraventricular Nucleus of Thalamus><Paraventricular Thalamic Nucleus><Pathologic><Pattern><Peptides><Pharmaceutical Preparations><Phase><Physiopathology><Play><Population><Position><Positioning Attribute><Positive Valence><Property><Punishment><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Project Grants><Research Projects><Resistance><Rewards><Rodent><Rodent Model><Rodentia><Rodents Mammals><Role><Route><Saccharose><Scientific Advances and Accomplishments><Secure><Self Administered><Self Administration><Shock><Signal Transduction><Signal Transduction Systems><Signaling><Site><Source><Structure of paraventricular nucleus of thalamus><Substance Use Disorder><Sucrose><Testing><Thalamic structure><Thalamus><Training><Transmission><Universities><Viral><Visualization><adaptation behavior><adaptive behavior><addicted to cocaine><addiction><addiction to cocaine><addictive disorder><adverse consequence><adverse outcome><aminoacid><amygdaloid nuclear complex><approach behavior><behavior response><behavioral response><biological signal transduction><circulatory shock><classification algorithm><cocaine addicted><cocaine seeking><computer vision><computer-assisted instruction><computer-based education><computer-based instruction><computer-based learning><computer-based training><digital education><digital learning><discrimination task><drug addict><drug use><drug/agent><eLearning><electronic learning><electrophysiological><experiment><experimental research><experimental study><experiments><flexibility><flexible><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><glutamatergic><in vivo><infusions><internet-assisted education><internet-based training><knock-down><knockdown><machine based learning><motivated behavior><multimedia learning><neural><neural control><neural correlate><neural mechanism><neural regulation><neuromechanism><neuromodulation><neuromodulatory><neuronal><neuroregulation><neurotensin type 1 receptor><novel><on-line education><on-line learning><online education><online learning><optogenetics><pathophysiology><receptor expression><recreational drug use><resistant><response><scientific accomplishments><scientific advances><shocks><social role><substance use and disorder><technology-enhanced learning><tenure process><tenure track><thalamic><tool><transmission process><virtual learning><web-based instruction><web-based training>
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Swagata Goswami

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Dietary Control of the Pro-Metastatic Niche in Colorectal Cancer

Grant Number:

4R00CA287057-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/19/2024

End Date:

12/31/2028

Project Abstract

PROJECT SUMMARY Colorectal cancer (CRC) metastasis is a major cause of mortality, yet there is a distinct lack of therapies targeting metastasis. Among the major modifiable external factors known to affect CRC risk are diet and obesity; however, unlike cancer initiation, how pro-obesity high fat die...

Research Terms

<Acceleration><Affect><Antioncogene Protein p53><Automobile Driving><Autoregulation><Bioinformatics><Biology><C-K-RAS><CRISPR><CRISPR/Cas system><Cancer Model><Cancer Patient><CancerModel><Cancers><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Signaling><Cell-Mediated Lympholytic Cells><Cell-to-Cell Interaction><Cells><Cellular Metabolic Process><Cellular Tumor Antigen P53><Cessation of life><Clustered Regularly Interspaced Short Palindromic Repeats><Colon><Colonoscopy><Colorectal Cancer><Computer Analysis><Cues><Cytolytic T-Cell><Cytotoxic T Cell><Cytotoxic T-Lymphocytes><DNA mutation><Data><Death><Diet><Dietary Intervention><Disease><Disorder><Educational process of instructing><Educational workshop><Evidence based practice guidelines><Evolution><Exercise><Fibroblasts><Future><GI Stem cell><Genetic Change><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic defect><Genetic mutation><Goals><Hepatic Neoplasm Secondary><Hepatic metastasis><High Fat Diet><Homeostasis><Human><Immune><Immunes><Impairment><Injury><Intracellular Communication and Signaling><Investigation><K-RAS2A><K-RAS2B><K-Ras><K-Ras 2A><K-Ras-2 Oncogene><KO mice><KRAS><KRAS2><KRAS2 gene><Ki-RAS><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Life Style><Lifestyle><Literature><Liver><Liver secondaries><Liver secondary cancer><Lymphatic cell><Lymphocyte><Lymphocytic><MAC393 antigen><MMAC1><MMAC1 protein><Macrophage><Malignant Neoplasms><Malignant Tumor><Mediating><Mentors><Mentorship><Metabolic><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Neoplasm to the Liver><Metastatic Tumor><Metastatic Tumor to the Liver><Metastatic malignant neoplasm to liver><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Mutated in Multiple Advanced Cancers 1><Mutation><Mφ><Natural regeneration><Neoplasm Metastasis><Null Mouse><Nutrient availability><Nutrition Interventions><Nutritional Interventions><Obesity><Oncogene K-Ras><Oncogenic><Oncoprotein p53><Operative Procedures><Operative Surgical Procedures><Organoids><Outcome><P53><PHTS gene><PHTS protein><PTEN><PTEN gene><PTEN protein><PTEN1><Pathology><Phase><Phenotype><Phosphatase and Tensin Homolog><Phosphatase and Tensin Homolog Deleted on Chromosome 10><Phosphoprotein P53><Phosphoprotein pp53><Physiologic><Physiological><Physiological Homeostasis><Population><Progenitor Cells><Protein TP53><Proteins><RASK2><Recombinant DNA Technology><Recommendation><Regeneration><Regulation><Reporter><Research><Role><SGP-2 protein><SGP2><SP 40,40 protein><Secondary Neoplasm><Secondary Tumor><Signal Transduction><Signal Transduction Systems><Signaling><Stem Cell like><Stromal Cells><Stromal Neoplasm><Stromal Tumor><Surgical><Surgical Interventions><Surgical Procedure><System><T-Cells><T-Lymphocyte><TP53><TP53 gene><TRP53><TRPM-2 protein><TRPM2><Teaching><Testing><Therapeutic><Training><Transplantation><Tumor Cell><Tumor Protein p53><Tumor Protein p53 Gene><Workshop><X-ray-inducible protein 8><XIP8 protein><adiposity><apoJ protein><apolipoprotein J><biological signal transduction><cancer cell metabolism><cancer initiation><cancer metabolism><cancer metastasis><cancer microenvironment><cancer progenitor><cancer progenitor cells><cancer progression><cancer risk><cancer stem cell><cancer stem like cell><career><cell metabolism><cellular metabaolism><clusterin><colorectal cancer metastasis><colorectal cancer risk><combat><complement lysis inhibitor><complement-associated protein SP-40,40 protein><computational analyses><computational analysis><computer analyses><conference><convention><corpulence><diet control><diet intervention><diet-associated obesity><diet-induced obesity><diet-related obesity><dietary><dietary control><diets><driver lesion><driver mutation><driving><epidemiology research study><epidemiology study><epidemiology survey><evidence base><evidence based guidelines><evidence based recommendations><gastrointestinal><gastrointestinal stem cell><genetically engineered><genome mutation><gut progenitor><gut stem cell><hepatic body system><hepatic organ system><in vivo><in vivo Model><injuries><innovate><innovation><innovative><insight><intervention design><intestinal epithelium><intestinal progenitor><intestinal stem cells><ionizing radiation-induced protein-8><killer T cell><liver metastases><lymph cell><malignancy><malignant liver neoplasm, specified as secondary><malignant progenitor><malignant stem cell><metabolism measurement><metabolomics><metabonomics><metastasis in the liver><metastasis to the liver><metastasize to the liver><metastatic cancer to liver><metastatic colo-rectal><metastatic colo-rectal cancer><metastatic colo-rectal carcinoma><metastatic colon cancer><metastatic colorectal><metastatic colorectal cancer><metastatic colorectal carcinoma><metastatic liver><metastatic liver neoplasm><mortality><mouse model><murine model><mutated in multiple advanced cancers 1 protein><neoplasm progression><neoplasm/cancer><neoplastic cell><neoplastic progression><obesity-promoting diet><obesogenic Western-style diet><obesogenic diet><obesogenic high fat diet><obesogenic western diet><oncogenic progenitor><oncogenic stem cells><p53 Antigen><p53 Genes><p53 Tumor Suppressor><phosphatase and tensin homologue on chromosome ten><prevent><preventing><pro-obesity diet><progenitor capacity><progenitor cell like><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor like cancer cell><progenitor niche><progenitor pool><progenitor population><progenitor-like><programs><protein p53><regenerate><regenerative><response><scRNA sequencing><scRNA-seq><secondary liver malignancy><secondary malignant liver neoplasm><single cell RNA-seq><single cell RNAseq><single cell analysis><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor cell niche><stem and progenitor cell population><stem cell characteristics><stem cell niche><stem cell pool><stem cell population><stem cells><stem like cancer cell><stem-like><stemness><sulfated glycoprotein 2><summit><surgery><symposia><symposium><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><testosterone-repressed prostate message-2 protein><therapy design><thymus derived lymphocyte><transplant><transplant model><treatment design><tumor><tumor cell metabolism><tumor cell metastasis><tumor initiation><tumor metabolism><tumor microenvironment><tumor progression><v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog>
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Yanaira Alonso Caraballo

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Mapping the Functional and Anatomical Pathways from the Anterior and Posterior Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens: Implications for Opioid Use

Grant Number:

4R00DA060895-02

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2024

End Date:

11/30/2028

Project Abstract

PROJECT ABSTRACT Opioid Use Disorder (OUD) is a complex medical condition characterized by compulsive and maladaptive use of opioid substances, including prescribed pharmaceuticals (such as oxycodone) and illegal agents (such as heroin). It causes physiological, psychological, and sociological effec...

Research Terms

<Abate><Abstinence><Address><Adopted><Anatomic Sites><Anatomic structures><Anatomy><Animals><Anterior><Appetite><Behavior><Brain><Brain Nervous System><Brain region><Calcium><Calcium Ion Signaling><Calcium Signaling><Chemical Dependence><Common Rat Strains><Complex><Comprehension><Cue-induced relapse><Cues><Data><Desire for food><Diacetylmorphine><Diamorphine><Differences between sexes><Differs between sexes><Dihydrohydroxycodeinone><Dissection><Drug Addiction><Drug Dependence><Drug Dependency><Drug usage><Drugs><Electrophysiology><Electrophysiology (science)><Encephalon><Endocrine Gland Secretion><Estrous Cycle><Female><Fiber><Foundations><Future><Glutamates><Goals><Grant><Heroin><Hormones><Human><Image><Impairment><Individual><Intravenous><Investigators><Knowledge><L-Glutamate><Link><Longitudinal Studies><Longitudinal Surveys><Maps><Measures><Medical><Medication><Methodology><Modern Man><Modernization><Monitor><Nerve Cells><Nerve Transmitter Substances><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Neurosciences><Neurotransmitters><Nucleus Accumbens><Opiates><Opioid><Optics><Outcome><Ovarian hormone><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><Paraventricular Nucleus of Thalamus><Paraventricular Thalamic Nucleus><Pathway interactions><Pattern><Pharmaceutical Agent><Pharmaceutical Preparations><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Phase><Photometry><Physiologic><Physiological><Physiology><Postdoc><Postdoctoral Fellow><Prevention><R-Series Research Projects><R01 Mechanism><R01 Program><Rat><Rat Transgene><Rats Mammals><Rattus><Recovery><Relapse><Research><Research Associate><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Rewards><Risk><Rodent><Rodentia><Rodents Mammals><Role><Roxicodone><Self Administered><Self Administration><Severities><Sex Differences><Sexual differences><Sociology><Solid><Structure of paraventricular nucleus of thalamus><Symptoms><Synapses><Synaptic><Synaptic plasticity><System><Techniques><Testing><Thalamic structure><Thalamus><Therapeutic Hormone><Transmission><Withdrawal Symptom><Work><abused drug><abused drugs><addiction><addictive disorder><affective neuroscience><cell type><comparing females and males><comparing women and men><compulsion><craving><daily functioning><debilitating symptom><design><designing><drug abused><drug of abuse><drug use><drug/agent><drugs abused><drugs of abuse><electrophysiological><experience><experiment><experimental research><experimental study><experiments><females compared to males><females compared with males><females versus males><females vs. males><glutamatergic><imaging><improved><in vivo><innervation><innovate><innovation><innovative><intravenous opiate><intravenous opioid><long-term recovery><long-term study><longitudinal outcome studies><longitudinal research study><male><negative affect><negative affectivity><nerve supply><neural circuit><neural circuitry><neural mechanism><neurocircuitry><neuromechanism><neuronal><opiate consumption><opiate drug use><opiate injection><opiate intake><opiate use><opiate use disorder><opiate withdrawal><opioid consumption><opioid detox><opioid detoxification><opioid drug use><opioid injection><opioid injector><opioid intake><opioid use><opioid use disorder><opioid withdrawal><optical><optogenetics><oxycodone self-administration><pathway><pharmaceutical><post-doc><post-doctoral><post-doctoral trainee><programs><prolonged abstinence><psychologic><psychological><relapse risk><research associates><response><self-administer oxycodone><sensor><sex><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><social role><sustained abstinence><synapse><synapse function><synaptic circuit><synaptic circuitry><synaptic function><thalamic><tool><transmission process><women compared to men><women compared with men><women versus men><women vs. men><♀><♂>
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Victoria Alice Macht

UNIVERSITY OF NORTH CAROLINA WILMINGTON, WILMINGTON, NC

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Adolescent intermittent ethanol induction of neuroimmune signaling disrupts the mature phenotype of surviving hippocampal neuroprogenitors

Grant Number:

5R00AA030089-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/10/2025

End Date:

2/29/2028

Project Abstract

PROJECT SUMMARY Adolescent binge drinking hijacks the developing brain, resulting in long-lasting increases in neuroinflammation which are paralleled by decreases in hippocampal neurogenesis and deficits in learning and memory-related tasks. Unlike adult alcohol exposure, the cellular and behavioral...

Research Terms

<0-4 weeks old><12-20 years old><21+ years old><Absolute ethanol><Abstinence><Address><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Alcohol Chemical Class><Alcohols><Ammon Horn><Amphoterin><Amphoterin Gene><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Anticholinesterase Agents><Anticholinesterase Drugs><Anticholinesterases><Antiphosphodiesterases><Astrocytes><Astrocytus><Astroglia><Astroprotein><Automobile Driving><Behavior><Behavioral><Brain><Brain Nervous System><CCL2><CCL2 gene><CNS plasticity><COX-2><COX2><Cell Body><Cell Communication and Signaling><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cell Signaling><Cells><Cellular Proliferation><Chemokine, CC Motif, Ligand 2><Cholinesterase Inhibitors><Chromosomal Protein, Nonhistone, HMG1><Chromosomal Protein, Nonhistone, HMG1 Gene><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cornu Ammonis><Data><Deoxyuridine><Development><Disturbance in cognition><Dominance Hierarchy><Drug Therapy><ETOH><Electrophysiology><Electrophysiology (science)><Encephalon><Equilibrium><Ethanol><Ethyl Alcohol><Euthanasia><FBJ osteosarcoma oncogene><FM1 Gene Product><FOS gene><Female><Functional impairment><Future><G0S7><GFA-Protein><GFAP><Galantamin><Galantamine><Galanthamine><Gatekeeping><Gene Expression><Glia><Glial Cells><Glial Fibrillary Acid Protein><Glial Fibrillary Acidic Protein><Glial Intermediate Filament Protein><Glycyrrhizic Acid><Glycyrrhizin><Glycyrrhizinic Acid><Grain Alcohol><HMG-1><HMG-1 Gene><HMG-1 Protein><HMG1><HMG1 Gene><HMG3><HMG3 Gene><HMGB1><HMGB1 Protein><HMGB1 gene><Heparin-Binding Protein p30><High Mobility Group Box Protein 1><High Mobility Group Protein 1><High Mobility Group Protein 1 Gene><High-Mobility Group (Nonhistone Chromosomal) Protein 1><High-Mobility Group (Nonhistone Chromosomal) Protein 1 Gene><High-Mobility Group Box 1><High-Mobility Group Box 1 Gene><Hippocampus><Histologic><Histologically><Homolog of Drosophila TOLL><Hortega cell><Immediate-Early Genes><Immune><Immunes><Immunofluorescence><Immunofluorescence Immunologic><Impaired cognition><Impairment><Indocin><Indometacin><Indomethacin><Inflammatory><Intervention><Intracellular Communication and Signaling><Knowledge><Kolliker's reticulum><Label><Learning><Link><Lycoremine><MCAF><MCP-1><MCP1><Maps><Mediating><Memory><Mercy Killing><Methylcarbinol><Mice><Mice Mammals><Microglia><Monocyte Chemoattractant Protein-1><Monocyte Chemotactic Protein-1><Monocyte Chemotactic and Activating Factor><Monocyte Chemotactic and Activating Protein><Monocyte Chemotactive and Activating Factor><Monocyte Secretory Protein JE><Morphology><Murine><Mus><N Methyl D aspartic Acid><N methyl D aspartate><N-Methyl-D-aspartate><N-Methylaspartate><NMDA><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neuroimmune><Neuronal Differentiation><Neuronal Plasticity><Neurons><Neurophysiology / Electrophysiology><Newborn Infant><Newborns><Non-neuronal cell><Nonhistone Chromosomal Protein HGM1><Nonhistone Chromosomal Protein HGM1 Gene><Nonneuronal cell><PGHS-2><PHS-2><PTGS2><PTGS2 gene><Performance><Pharmacological Treatment><Pharmacotherapy><Phenotype><Phosphodiesterase Antagonists><Phosphodiesterase Inhibitors><Phosphoric Diester Hydrolase Inhibitors><Physiologic><Physiological><Population><Predisposition><Property><Protooncogene FOS><Regulation><Reporter><Research><Research Training><Reversal Learning><SBP-1><SBP-1 Gene><SCYA2><Signal Transduction><Signal Transduction Systems><Signaling><Small Inducible Cytokine A2><Social Dominance><Stress><Sulfoglucuronyl Carbohydrate Binding Protein><Sulfoglucuronyl Carbohydrate Binding Protein Gene><Susceptibility><TLR4><TLR4 gene><Tamoxifen><Techniques><Testing><Toll Homologue><Training><Transgenic Mice><Transgenic Model><Transgenic Organisms><Trees><Tube><adolescence (12-20)><adolescent alcohol binge exposure><adolescent alcohol exposure><adolescent binge alcohol drinking><adolescent binge drinking><adolescent ethanol exposure><adolescent exposure to alcohol><adolescent exposure to ethanol><adolescent intermittent ethanol exposure><adolescent onset binge drinking><adult neurogenesis><adulthood><alcohol exposed><alcohol exposure><alcohol exposure during adolescence><antagonism><antagonist><astrocytic glia><balance><balance function><biological signal transduction><brain circuitry><c fos><c-fos Gene><c-fos Proto-Oncogenes><central nervous system plasticity><cognitive dysfunction><cognitive loss><developmental><driving><drug intervention><drug treatment><electrophysiological><ethanol exposed><ethanol exposure><ethanol exposure during adolescence><experiment><experimental research><experimental study><experiments><exposed to alcohol><exposed to ethanol><exposure to alcohol><exposure to ethanol><flexibility><flexible><gatekeeper><gitter cell><hCOX-2><hippocampal><inflammation marker><inflammatory marker><insight><intraperitoneal><juvenile><juvenile human><life span><lifespan><male><memory recognition><mesoglia><microglial cell><microgliocyte><morris water maze><morris watermaze><nerve cement><nerve stem cell><neural circuit><neural circuitry><neural inflammation><neural plasticity><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurocircuitry><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuroinflammation><neuroinflammatory><neuron progenitors><neuronal><neuronal excitability><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuronal survival><neuroplastic><neuroplasticity><neuroprogenitor><newborn child><newborn children><newborn neuron><novel><object recognition><optogenetics><p65><perivascular glial cell><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><postnatal><postsynaptic><progenitor and neural stem cells><programs><restoration><sex><social stress><socially stressed><synaptic circuit><synaptic circuitry><therapeutic target><toll-like receptor 4><tool><transgenic><transgenic trait><v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog><♀><♂>
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Huize Pan

VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Genomic Regulation and Translational Potential of a Novel Smooth Muscle Cell-Derived Cell Type in Atherosclerosis

Grant Number:

5R00HL153939-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2026

Project Abstract

Smooth muscle cells (SMCs) play major roles in atherosclerosis, a leading cause of cardiovascular disease (CVD). SMCs can be beneficial or detrimental in atherosclerosis, depending on their transdifferentiation trajectories into atheroprotective (e.g., fibroblast-like cell) or atherogenic (e.g., mac...

Research Terms

<9-cis-Retinoic Acid Receptor><ASCVD><ATRA><Acceleration><Address><Advisory Committees><Apoptosis><Apoptosis Pathway><Applications Grants><Area><Arterial Fatty Streak><Atherogenicity><Atheroma><Atheromatous><Atheromatous degeneration><Atheromatous plaque><Atherosclerosis><Atherosclerosis-prone><Atherosclerosis-susceptible><Atherosclerotic Cardiovascular Disease><Atherosclerotic cap><Attenuated><Award><Biochemical><Blood monocyte><Cardiovascular Diseases><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Complex><Data><Development><Disease Progression><Disease regression><ENX-1><EZH1><EZH2><EZH2 gene><Endothelial Cells><Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Equilibrium><Fibroblasts><Fibrous Cap><Gene Down-Regulation><Gene Expression><Genes><Genetic Markers><Genomics><Grant Proposals><Human><Immune Precipitation><Immunoprecipitation><Inflammasome><Inflammation><Inflammatory><Inflammatory Response><Intracellular Communication and Signaling><Investigation><Investigators><KMT6><KMT6A><Leadership><Leiomyocyte><Lesion><Lineage Tracing><Link><Liver X Receptor><Macrophage><Manuscripts><Marrow monocyte><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Mice><Mice Mammals><Modern Man><Molecular><Molecular Target><Murine><Mus><Mφ><Necrosis><Necrotic><Pathway interactions><Phase><Phenotype><Play><Preparation><Prevention><Progenitor Cells><Program Development><Programmed Cell Death><Prone to atherosclerosis><RXR><RXR Protein><Regulation><Repression><Research><Research Personnel><Research Training><Researchers><Retinoic Acid><Retinoic Acid Receptor><Retinoic Acid Receptor RXR><Retinoid X Receptors><Role><Signal Repression><Signal Transduction><Signal Transduction Systems><Signaling><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Stimulus><Subcellular Process><Task Forces><Techniques><Testing><Thick><Thickness><Time><Trans Vitamin A Acid><Transcription Repression><Tretinoin><Tretinoinum><Vitamin A Acid><Work><advanced disease><advanced illness><advisory team><all-trans-Retinoic Acid><all-trans-Vitamin A acid><antagonism><antagonist><atheromatosis><atheroprone><atheroprotection><atheroprotective><atherosclerosis plaque><atherosclerotic disease><atherosclerotic lesions><atherosclerotic plaque><atherosclerotic vascular disease><attenuate><attenuates><balance><balance function><biological signal transduction><cardiovascular disorder><career><career development><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular differentiation><cellular lineage mapping><cellular lineage tracking><cellular targeting><design><designing><developmental><epigenetic regulation><epigenetically><gene biomarker><gene expression biomarker><gene marker><gene repression><gene signature biomarker><genetic biomarker><histologic stains><histological stains><inhibitor><insight><migration><monocyte><mouse model><murine model><novel><pathway><plaque cap><plaques in atherosclerosis><preparations><progenitor cell markers><progenitor markers><progenitor stem cell markers><promoter><promotor><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><stem cell biomarkers><stem cell markers><stem cells><susceptibility to atherosclerosis><trans-Retinoic Acid><transdifferentiation><translational opportunities><translational potential><vascular smooth muscle cell proliferation><western diet><western-style diet><western-type diet>
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Li Wang

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Identifying mechanisms ofsynapse maturation at neuronal subtype resolution

Grant Number:

4R00MH131832-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2023

End Date:

12/31/2028

Project Abstract

Project Summary/Abstract The human brain function relies on the formation and maintenance of precise neural circuits among more than 100 subtypes of neurons. These circuits are mediated by synapses, the characteristics of which vary depending on neuronal subtype. Synaptic dysfunction plays a critica...

Research Terms

<ARHGEF5><ARHGEF5 gene><ASD><Acute><Adaptive Behaviors><Affect><Autism><Autistic Disorder><Award><Behavior><Biology><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Cell Body><Cells><Cerebral cortex><Characteristics><Chemical Synapse><Chromatin><Connector Neuron><Critical Paths><Critical Pathways><DNA mutation><DREADDs><Data><Development><Disease><Disorder><Dysfunction><Early Infantile Autism><Encephalon><Encephalon Diseases><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exhibits><Expression Signature><Foundations><Functional disorder><Future><GEF5><Gene Expression><Gene Expression Profile><Gene Transcription><Genes><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genetic study><Glutamates><Goals><Heterogeneity><Human><Individual><Infantile Autism><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Knowledge><L-Glutamate><Label><Learning><Link><Long-Term Effects><Machine Learning><Maintenance><Mediating><Mental disorders><Mental health disorders><Mentors><Methods><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neural Transmission><Neurocyte><Neurons><P60><Pathway interactions><Patients><Phase><Physiopathology><Play><Process><Property><Proteins><Proteome><Proteomics><Psychiatric Disease><Psychiatric Disorder><R-Series Research Projects><R01 Mechanism><R01 Program><RNA Expression><Research><Research Grants><Research Project Grants><Research Projects><Resolution><Risk Factors><Rodent Model><Role><Solid><Specificity><Synapses><Synaptic><Synaptic Transmission><Synaptic plasticity><TIM1><Techniques><Testing><Training><Transcription><Transcriptional Control><Transcriptional Regulation><adaptation behavior><adaptive behavior><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><career><cell type><critical period><density><designer receptors exclusively activated by designer drugs><developmental><developmental neurobiology><epigenetically><experience><gene expression pattern><gene expression signature><gene regulatory network><genome mutation><glutamatergic><in vivo><insight><knock-down><knockdown><machine based learning><machine learning based method><machine learning method><machine learning methodologies><mental illness><multiomics><multiple omics><neural circuit><neural circuitry><neurocircuitry><neuronal><novel><panomics><pathophysiology><pathway><postsynaptic><postsynaptic density protein><programs><protein complex><psychiatric illness><psychological disorder><resolutions><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell genomics><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><spatial and temporal><spatial temporal><spatiotemporal><synapse><synapse formation><synaptic circuit><synaptic circuitry><synaptogenesis><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><temporal measurement><temporal resolution><time measurement><tool><transcriptional profile><transcriptional signature>
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Wenqing Zhou

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Defining a novel transcriptional regulator of intestinal health and inflammation

Grant Number:

4R00DK135923-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/8/2024

End Date:

3/31/2029

Project Abstract

Project Summary/Abstract The gastrointestinal tract is colonized by trillions of normally beneficial microbes (termed the microbiota), as well as serves as an entry site for pathogens. Therefore, the intestinal immune system must remain tolerant to foreign non-harmful stimuli meanwhile provide prote...

Research Terms

<Ablation><Acute><Address><Advisory Committees><Alimentary Canal><Antigens><Area><Assay><Autoregulation><Award><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Biological Assay><Body Tissues><CCR6><CCR6 gene><CKRL3><CSIF><CSIF-10><CUT&RUN><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chemokine Receptor-Like 3><Chronic><Cleavage Targets and Release Using Nuclease><Cleavage Under Targets and Release Using Nuclease><Co-culture><Cocultivation><Coculture><Coculture Techniques><Colon><Colorectal Cancer><Communicable Diseases><Communication><Cytokine Synthesis Inhibitory Factor><DSS colitis><DSS model><DSS mouse model><DSS-induced acute colitis><DSS-induced colitis><Data><Dendritic Cells><Development><Digestive Tract><Disease><Disorder><Endothelial Cells><Exhibits><Exposure to><G Protein-Coupled Receptor 29><GI Tract><GPR29><GPRCY4><Gastrointestinal Tract><Gastrointestinal tract structure><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic><Genetic Risk><Genetic Transcription><Gnotobiotic><Gnotobiotics><Goals><Health><Health Promotion><Heterogeneity><Homeostasis><Human><Human Genome><IL-10><IL10><IL10A><Immune><Immune Regulators><Immune response><Immune system><Immunes><Immunity><Immunomodulation><Immunomodulators><Infection><Infection prevention><Infectious Diseases><Infectious Disorder><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Interleukin 10 Precursor><Interleukin-10><Intestinal><Intestinal Diseases><Intestinal Disorder><Intestines><Intracellular Communication and Signaling><Investigators><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Laboratories><Link><Lymphatic Tissue><Lymphatic cell><Lymphocyte><Lymphocytic><Lymphoid Cell><Lymphoid Tissue><Mediating><Mediator><Mentors><Metabolic Diseases><Metabolic Disorder><Mice><Mice Mammals><Modern Man><Molecular><Mucosal Immunity><Murine><Mus><Nature><Null Mouse><Pathogenesis><Pathway interactions><Patients><Permeability><Phase><Physiologic><Physiological><Physiological Homeostasis><Prevent infection><Preventive><Property><Publishing><RNA Expression><Regulation><Reporting><Research><Research Personnel><Researchers><Risk-associated variant><Role><STRL22><Salutogenesis><Scientific Advances and Accomplishments><Scientist><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Site><Stimulus><Stromal Cells><Task Forces><Techniques><Testing><Therapeutic><Thesaurismosis><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Veiled Cells><Work><Writing><advisory team><alimentary tract><beneficial flora><beneficial microbes><beneficial microflora><beneficial microorganism><biological signal transduction><bowel><bowel inflammation><career><cell type><colitis-induced dysbiosis><developmental><dextran sulfate sodium colitis><dextran sulfate sodium induced colitis><dextran sulfate sodium model><dextran sulfate sodium mouse model><dietary><digestive canal><enteral infection><enteric infection><enteric pathogen infection><enteropathogen infection><enteropathogenic infection><experience><fitness><fundamental research><gastrointestinal><gut inflammation><host response><human whole genome><immune modulation><immune modulators><immune regulation><immune system response><immunogen><immunologic reactivity control><immunomodulatory><immunomodulatory molecules><immunoregulation><immunoregulator><immunoregulatory><immunoregulatory molecules><immunoresponse><in vivo><infected with enteropathogen><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><intestinal autoinflammation><intestinal infection><intestinal inflammation><intestine disease><intestine disorder><intestine infection><lymph cell><metabolism disorder><microbial consortia><microbial flora><microbiota><microbiota composition><microflora><multidisciplinary><multispecies consortia><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><overexpress><overexpression><pathogen><pathway><promoting health><restraint><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><scRNA sequencing><scRNA-seq><scientific accomplishments><scientific advances><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><training opportunity><transcription factor><translational study>
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Deborah Joyce Luessen

EMORY UNIVERSITY, ATLANTA, GA

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Mechanisms of mGlu1 regulation of cortical inhibition and cognitive function: Implications in adolescent cocaine exposure

Grant Number:

4R00DA058712-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2029

Project Abstract

PROJECT SUMMARY/ABSTRACT Evidence suggests that cocaine use, notably during critical neurodevelopmental periods like adolescence, is associated with significant and persistent impairments in cognitive processes like working memory and cognitive flexibility. Cognitive symptoms are associated with los...

Research Terms

<12-20 years old><21+ years old><Adherence><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Behavioral><Brain region><Cell Body><Cells><Cocaine><Cocaine Addiction><Cocaine Dependence><Cocaine use disorder><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive Manifestations><Cognitive Symptoms><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Communication><Connector Neuron><Cyclic Somatostatin><Data><Disturbance in cognition><Drug Exposure><Drugs><Dysfunction><Electrophysiology><Electrophysiology (science)><Fiber><Foundations><Functional disorder><GPRC1A><GRM1><GRM1 gene><GRM1A><Goals><Growth Hormone Inhibiting Factors><Growth Hormone-Inhibiting Hormone><Image><Immediate Memory><Impaired cognition><Impairment><Individual><Intercalary Neuron><Intercalated Neurons><Interneuron function><Interneurons><Internuncial Cell><Internuncial Neuron><MGLUR1><MGLUR1A><Mediating><Medication><Mentors><Metabotropic Glutamate Receptors><Mice><Mice Mammals><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neurobiology><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Output><Performance><Pharmaceutical Preparations><Pharmacology><Phase><Photometry><Physiologic><Physiological><Physiopathology><Population><Prefrontal Cortex><Receptor Protein><Regulation><Reporter Genes><Research><Risk><Rodent Model><Role><SRIH><SRIH-14><Series><Short-Term Memory><Somatostatin><Somatostatin-14><Somatotropin Release Inhibiting Factors><Somatotropin Release-Inhibiting Hormone><Stimulus><Substance Use Disorder><Synapses><Synaptic><Techniques><Testing><Therapeutic><Time><Training><Transgenic Mice><Transgenic Organisms><Transmission><addicted to cocaine><addiction to cocaine><adolescence (12-20)><adulthood><associated symptom><career><cell type><co-morbid symptom><co-occuring symptom><cocaine addicted><cocaine exposure><cocaine use><cocaine-exposed><cognitive assessment><cognitive defects><cognitive dysfunction><cognitive function><cognitive loss><cognitive performance><cognitive process><cognitive testing><comorbid symptom><concurrent symptom><cooccuring symptom><critical period><determine efficacy><drug abuse vulnerability><drug/agent><early onset><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><electrophysiological><evaluate efficacy><examine efficacy><exposed to cocaine><exposure to cocaine><exposure to psychostimulants><exposure to stimulants><flexibility><flexible><growth hormone release inhibiting factor><imaging><improved><in vivo><insight><interest><juvenile><juvenile human><later in life><later life><mGlu1><neurobiological><neurodevelopment><neuronal><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><patch clamp><pathophysiology><pharmacologic><positive allosteric modulator><psychostimulant exposure><receptor><social role><stimulant exposure><substance use and disorder><symptom association><symptom comorbidity><synapse><therapeutic target><tool><touch panel><touch screen><touch screen panel><touchscreen><touchscreen panel><transgenic><transmission process><vulnerability to drug abuse><working memory>
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Joshua Heyza

WAYNE STATE UNIVERSITY, DETROIT, MI

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Molecular regulation of double-strand break repair by MDC1

Grant Number:

5R00GM149942-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2023

End Date:

2/29/2028

Project Abstract

Project Summary: DNA double strand breaks (DSB) pose harmful threats to genomic integrity. For this reason, cells evolved a diverse set of tightly regulated pathways dedicated to repairing these lesions. In human cells, two major pathways are responsible for repairing most DSBs, including Homologous...

Research Terms

<53BP1><Active Sites><Adaptor Protein><Adaptor Protein Gene><Adaptor Signaling Protein><Adaptor Signaling Protein Gene><Affinity><Alleles><Allelomorphs><Assay><Award><BRCA1><BRCA1 Gene Product><BRCA1 Protein><BRCA1 gene><Binding><Bioassay><Biochemical><Biological Assay><Breast Cancer 1 Gene><Breast Cancer 1 Gene Product><Breast Cancer Type 1 Susceptibility Gene><Breast Cancer Type 1 Susceptibility Protein><Breast-Ovarian Cancer Protein><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas9 screen><Cancers><Cell Body><Cell Cycle><Cell Division Cycle><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Chromatin><Complex><Coupled><DNA Damage><DNA Damage Repair><DNA Double Strand Break><DNA Injury><DNA Recombination><DNA Repair><DNA damage check point><DNA damage check point response><DNA damage checkpoint><DNA damage checkpoint response><DNA lesion><DNA mutation><Data><Dedications><Development><Disease><Disorder><Double Strand Break Repair><Early Onset Gene Breast Cancer 1><Early Onset Protein Breast Cancer 1><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Eukaryotic Cell><Funding><Future><G2 Phase><G2 period><Gamma-H2AX><Gap Phase 2><Gene Transcription><Genetic Change><Genetic Recombination><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Genome Stability><Genomic Stability><Grant><Health><Hereditary Breast Cancer 1><Histones><Human><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Lesion><Link><Maintenance><Malignant Neoplasms><Malignant Tumor><Mediating><Mediator><Mentors><Modeling><Modern Man><Molecular><Molecular Interaction><Mutation><NHEJ><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Non-Homologous End Joining><Non-Polyadenylated RNA><Non-homologous DNA End Joining><Nonhomologous DNA End Joining><Nonhomologous End Joining><Nucleosomes><Outcomes Research><Pathway interactions><Phase><Phosphorylation><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Postdoc><Postdoctoral Fellow><Posttranslational Modifications><Posttranslational Protein Processing><Process><Protein Modification><Protein Phosphorylation><Proteins><RNA><RNA Expression><RNA Gene Products><RNF53><Recombinants><Recombination><Regulation><Reporter><Research><Research Associate><Ribonucleic Acid><Role><Second Gap Phase><Series><Site><TP53BP1><Testing><Training><Transcript><Transcription><Ubiquitilation><Ubiquitination><Ubiquitinoylation><Unscheduled DNA Synthesis><Variant><Variation><Work><adapter protein><biophysical approaches><biophysical methodology><biophysical methods><biophysical techniques><brca 1 gene><cartilage link protein><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><clustered regularly interspaced short palindromic repeats screen><developmental><epigenetically><gene locus><genetic locus><genome integrity><genome mutation><genome scale><genome-wide><genomewide><genomic integrity><genomic location><genomic locus><homologous recombination><imaging study><innovate><innovation><innovative><insight><link protein><live cell image><live cell imaging><live cellular image><live cellular imaging><malignancy><molecular imaging><molecule imaging><mutant><neoplasm/cancer><neurological disease><p202><p53-binding protein 1><p53BP1><pathway><post-doc><post-doctoral><post-doctoral trainee><postmitotic><programs><recruit><repair><repair function><repaired><reparative function><research associates><response><single molecule><social role><ubiquination><ubiquitin conjugation><γH2AX>
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Junhong Choi

SLOAN-KETTERING INST CAN RESEARCH, NEW YORK, NY

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Molecular recording to understand the determinants of cell fate transitions in early development

Grant Number:

5R00HG012973-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2024

End Date:

2/28/2027

Project Abstract

Project Summary During mammalian development, a single cell gives rise to thousands of diverse and functionally distinct cell-types. Understanding how each cell-type is determined during development is one of the central questions in biology with far-reaching consequences for human health and regen...

Research Terms

<Assay><Bioassay><Biologic Models><Biological Assay><Biological Models><Biology><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><Cell Body><Cell Communication and Signaling><Cell Lineage><Cell Signaling><Cell model><Cells><Cellular model><Complex><DNA><Data><Decision Making><Deoxyribonucleic Acid><Development><Developmental Biology><Developmental Process><Embryo><Embryonic><Event><Foundations><Gene Activation><Gene Transcription><Genetic Transcription><Genome><Genomics><Goals><Health><History><Human><Intracellular Communication and Signaling><Lineage Tracing><Link><Mammalian Cell><Measurement><Mentors><Mentorship><Methods><Mice><Mice Mammals><Microscopy><Mission><Modality><Model System><Modeling><Modern Man><Molecular><Morphogenesis><Murine><Mus><NHGRI><National Center for Human Genome Research><National Human Genome Research Institute><Organism><Outcome><Phase><Position><Positioning Attribute><Process><RNA Expression><Recording of previous events><Regenerative Medicine><Research><Resolution><Scientific Inquiry><Signal Transduction><Signal Transduction Systems><Signaling><Specific qualifier value><Specified><Structure><System><Systems Development><Techniques><Technology><Testing><Transcription><Transcription Activation><Transcriptional Activation><biological signal transduction><career><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular development><cellular lineage mapping><cellular lineage tracking><clinical applicability><clinical application><design><designing><developmental><epigenome profiling><epigenomic profiling><experiment><experimental research><experimental study><experiments><genome editing><genomic editing><global gene expression><global transcription profile><histories><human genomics><improved><in vivo><insight><living system><model development><model developments><morphogenetic process><post-doctoral training><resolutions><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell genomics><single cell transcriptomic profiling><single-cell RNA sequencing><temporal measurement><temporal resolution><time measurement><tool><transcriptome><transcriptome profiling><transcriptomic profiling>
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Emilia M Lefevre

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Nucleus accumbens fast-spiking interneurons regulate opioid reward and addiction

Grant Number:

5R00DA052624-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

2/28/2027

Project Abstract

Project Abstract Opioid addiction is a public health crisis, characterized by compulsive drug seeking and a pervasive vulnerability to relapse, with few therapeutic options available. The nucleus accumbens (NAc) is a central hub within reward circuitry and plays a critical role in the motivational ...

Research Terms

<Actiq><Acute><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Award><Behavior><Biologic Factor><Biological Factors><Brain region><Calcium><Cell Body><Cells><Chronic><Connector Neuron><Cues><DREADDs><Data><Dependence><Development><Dihydrohydroxycodeinone><Drugs><Duragesic><Electrophysiology><Electrophysiology (science)><Epidemic><Female><Fentanest><Fentanyl><Fentyl><Fiber><Foundations><Future><Genetic><Genetic Technics><Genetic Techniques><Goals><Image><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intervention Strategies><Knowledge><Maintenance><Mediating><Mediator><Medication><Mentors><Mentorship><Mice><Mice Mammals><Minnesota><Mission><Modeling><Molecular><Motivation><Murine><Mus><NIDA><NIH><National Institute of Drug Abuse><National Institute on Drug Abuse><National Institutes of Health><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Nucleus Accumbens><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><Pathway interactions><Pattern><Pharmaceutical Preparations><Phase><Phentanyl><Photometry><Play><Population><Postdoc><Postdoctoral Fellow><Property><Protocol><Protocols documentation><Psychological reinforcement><Public Health><Publications><Reinforcement><Relapse><Research><Research Associate><Rewards><Role><Roxicodone><Scientific Publication><Self Administered><Self Administration><Synapses><Synaptic><Synaptic plasticity><Techniques><Testing><Thalamic structure><Thalamus><Therapeutic><Training><United States National Institutes of Health><Universities><Viral><addiction><addictive disorder><amygdaloid nuclear complex><attenuation><behavioral pharmacology><behavioral plasticity><career><career development><combat><design><designer receptors exclusively activated by designer drugs><designing><developmental><drug seeking behavior><drug/agent><effective intervention><electrophysiological><experiment><experimental research><experimental study><experiments><fentanyl self-administration><genetic approach><genetic strategy><imaging><in vivo><in vivo monitoring><innovate><innovation><innovative><male><mu opioid receptors><neural><neural circuit><neural circuitry><neural control><neural regulation><neurocircuitry><neuromodulation><neuromodulatory><neuronal><neuroregulation><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><opiate abuse><opiate crisis><opiate drug abuse><opiate use disorder><opioid abuse><opioid addiction><opioid crisis><opioid dependence><opioid dependent><opioid drug abuse><opioid epidemic><opioid use disorder><optogenetics><patch clamp><pathway><pharmacobehavioral><post-doc><post-doctoral><post-doctoral trainee><post-doctoral training><prevent><preventing><programs><public health relevance><research associates><response><reward circuitry><social role><source localization><synapse><synaptic circuit><synaptic circuitry><thalamic><tool><translational therapeutics><translational therapy><μ opioid receptors><μ-OR><μOR><♀><♂>
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Aki Ushiki

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Development of functional genomic technologies in mice

Grant Number:

5R00HG012576-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

2/29/2028

Project Abstract

PROJECT SUMMARY Mutations in gene regulatory elements (REs) are a major cause of human disease. For example, the majority (>90%) of disease related genome wide association studies (GWAS) found associations with variants in non- coding and likely regulatory regions in the genome. Despite their import...

Research Terms

<ATAC sequencing><ATAC-seq><ATACseq><Address><Adeno-Associated Viruses><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Associated Viruses><Bioassay><Biological Assay><Body Tissues><Brain><Brain Nervous System><CRISPR><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas system><CRISPR/Cas9 screen><Catalogs><Cell Body><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Chromosome Mapping><Clustered Regularly Interspaced Short Palindromic Repeats><Code><Coding System><Color><Complex><Cultured Cells><DNA><DNA Sequence><DNA Transposable Elements><DNA mutation><Data><Deoxyribonucleic Acid><Dependoparvovirus><Dependovirus><Development><Disease><Disorder><Double-Stranded DNA><Ectoderm><Electroporation><Elements><Embryo><Embryonic><Encephalon><Endoderm><Enhancer Elements><Enhancers><Ensure><Fallopian Tubes><Fertilized Egg><Fertilized Ovum><Functional RNA><Future><GWA study><GWAS><Gene Localization><Gene Mapping><Gene Mapping Genetics><Genes><Genetic Change><Genetic Enhancer Element><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Genome><Genomics><Germ Layers><Glycoproteins><Goals><Guide RNA><Heart><Heterozygote><High Throughput Assay><Human Genome><In Vitro><Individual><Investigators><Knock-out><Knockout><Lead><Libraries><Linkage Mapping><Liver><Mammalian Oviducts><Measures><Mentors><Mesoderm><Methods><Mice><Mice Mammals><Murine><Mus><Mutagenesis><Mutagenesis Molecular Biology><Mutation><Noncoding RNA><Nontranslated RNA><Nucleic Acid Regulator Regions><Nucleic Acid Regulatory Sequences><Nucleotides><Organism><Pb element><Penetration><Phase><Phenotype><Pregnant Women><Publications><Regulatory Element><Regulatory Regions><Reporter><Reporting><Research><Research Personnel><Researchers><Salpinx><Satellite Viruses><Scientific Publication><Serotyping><Single Base Polymorphism><Single Nucleotide Polymorphism><Specificity><System><Techniques><Technology><Testing><Thick><Thickness><Time><Tissues><Total Human and Non-Human Gene Mapping><Training><Transgenic Mice><Transposable Elements><Transposase><Untranslated RNA><Uterine Tubes><Variant><Variation><Zona Pellucida><adeno associated virus group><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><base editor><career><catalog><cell type><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><clustered regularly interspaced short palindromic repeats screen><developmental><ds-DNA><dsDNA><electroporative delivery><enhancer sequence><expectant mother><expectant women><expecting mother><expecting women><extracellular><functional genomics><gRNA><gain of function><gastrulation><gene electrotransfer><gene function><genetic enhancer sequence><genetic mapping><genetic regulatory element><genome mutation><genome scale><genome wide association><genome wide association scan><genome wide association study><genome-wide><genomewide><genomewide association scan><genomewide association study><genomic data><genomic dataset><genomic tools><heavy metal Pb><heavy metal lead><hepatic body system><hepatic organ system><heterozygosity><high throughput screening><high throughput technology><human disease><human whole genome><in vivo><individuals who are pregnant><living system><loss of function><noncoding><novel><oviduct><people who are pregnant><pregnant females><pregnant mothers><pregnant people><pregnant populations><prevent><preventing><prime editor><promoter><promotor><screening><screenings><single nucleotide variant><spatial and temporal><spatial temporal><spatiotemporal><those who are pregnant><tool><whole genome association analysis><whole genome association study><women who are pregnant><zygote>
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Xiaojie Qiu

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Predictive modeling of mammalian cell fate transitions over time and space with single-cell genomics

Grant Number:

5R00HG012887-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

12/31/2026

Project Abstract

Project summary Despite remarkable advances in single-cell profiling, machine learning and systems biology, our ability to exploit these measurements is limited by the lack of an appropriate framework to model and analyze them. In this application, I propose an organic synthesis of experimental tech...

Research Terms

<3-D><3-D modeling><3-Dimensional><3D><3D modeling><Address><Architecture><Atlases><Basal Transcription Factor><Basal transcription factor genes><Big Data><BigData><Biological><Blood Precursor Cell><C elegans><C. elegans><C.elegans><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Caenorhabditis elegans><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Signaling><Cell model><Cells><Cellular model><Chromatin><Chromium><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><Computational toolkit><Cr element><Cues><Data><Data Set><Development><Development Plans><Development and Research><Differential Algebraic Equation><Differential Equation><Digit><Digit structure><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Engineering / Architecture><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Future><General Transcription Factor Gene><General Transcription Factors><Genetic><Hematopoiesis><Hematopoietic><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Hour><Human><Intracellular Communication and Signaling><Investigators><Kinetics><Label><Learning><Lineage Tracing><Link><Machine Learning><Maintenance><Mammalian Cell><Maps><Math Models><Measurement><Measures><Mentors><Metabolic><Methods><Mice><Mice Mammals><Microscopy><Modeling><Modern Man><Modernization><Murine><Mus><Non-Polyadenylated RNA><Organic Synthesis><Organogenesis><Pancreas><Pancreatic><Paper><Paracrine Communication><Paracrine Signaling><Pattern><Phase><Position><Positioning Attribute><Predictive Factor><Progenitor Cells><Proteomics><Publishing><R & D><R&D><RNA><RNA Gene Products><Regenerative Medicine><Research><Research Personnel><Researchers><Ribonucleic Acid><Side><Signal Transduction><Signal Transduction Systems><Signaling><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Sum><System><Systems Biology><Technology><Testing><Time><Tracer><Training><Transcription Factor Proto-Oncogene><Transcription factor genes><Universities><Work><biologic><biological signal transduction><biological systems><blood cell formation><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><career development><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular differentiation><cellular lineage mapping><cellular lineage tracking><computational toolbox><computational tools><computational toolset><computer based prediction><computerized tools><deep learning><deep learning method><deep learning strategy><developmental><dynamic system><dynamical system><epigenetically><experiment><experimental research><experimental study><experiments><field based data><field learning><field study><field test><global gene expression><global transcription profile><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><improved><in silico><in situ sequencing><in vivo><innovate><innovation><innovative><insight><kernel learning><kernel methods><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><mathematic model><mathematical model><mathematical modeling><mouse model><multi-kernel learning><multi-modality><multimodality><multiomics><multiple omics><murine model><neural><neural network><new approaches><novel approaches><novel strategies><novel strategy><panomics><prediction algorithm><predictive modeling><progenitor><progenitor cell maintenance><progenitor maintenance><research and development><scRNA sequencing><scRNA-seq><simulation><single cell RNA-seq><single cell RNAseq><single cell analysis><single cell expression profiling><single cell genomics><single cell technology><single cell transcriptomic profiling><single-cell RNA sequencing><skills><spatial RNA sequencing><spatial and temporal><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial temporal><spatial temporal transcriptomics><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><spatiotemporal><spatiotemporal gene expression analysis><spatiotemporal gene expression patterns><spatiotemporal transcriptomics><statistical analysis><stem cell maintenance><stem cells><success><tech development><technology development><three dimensional><three-dimensional modeling><transcription factor><transcriptome><transcriptomics><vector>
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Fergil Mills

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Determining the role of amygdalostriatal transition zone circuits in associative learning and motivated behaviors

Grant Number:

5R00MH121563-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2021

End Date:

2/28/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT The brain is able to form learned associations between stimuli and the rewards or punishments they predict, which then guide appropriate behavioral responses to maximize survival. However, responses to environmental stimuli are severely altered in neurological disorders such...

Research Terms

<Allelism Test><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Animals><Anxiety><Association Learning><Associative Learning><Aversive Stimulus><Basic Research><Basic Science><Behavior><Behavioral><Bilateral><Biological><Brain><Brain Nervous System><Cell Body><Cell Nucleus><Cells><Complementation Test><Complex><Computer Analysis><Conditioned Reflex><Consensus><Corpus Striatum><Corpus striatum structure><Cues><Data><Data Analyses><Data Analysis><Disease><Disorder><Electrophysiology><Electrophysiology (science)><Encephalon><Event><Genetic Complementation Test><Health><Human><Investigators><Knowledge><Lateral><Learning><Mediating><Mental Depression><Mental disorders><Mental health disorders><Mentors><Methods><Modeling><Modern Man><Motor output><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic Disorders><Neurological Disorders><Neurons><Neurophysiology / Electrophysiology><Nucleus><Outcome><Output><PTSD><Pathologic><Pathway interactions><Pavlovian conditioning><Phase><Play><Population><Position><Positioning Attribute><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Predictive Value><Process><Psychiatric Disease><Psychiatric Disorder><Punishment><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Residual><Residual state><Rewards><Role><Sensory><Site><Slice><Source><Stimulus><Stream><Striate Body><Striatum><Structure><Synapses><Synaptic><Thalamic structure><Thalamus><Training><Trans Test><amygdaloid nuclear complex><associative conditioning><behavior outcome><behavior response><behavioral outcome><behavioral response><biologic><career development><classical conditioning><complementation analysis><complementation approach><computational analyses><computational analysis><computer analyses><conditioned fear><conditioned response><data interpretation><deep learning based neural network><deep learning neural network><deep neural net><deep neural network><depression><discrimination task><electrophysiological><experience><experiment><experimental research><experimental study><experiments><fear conditioning><fitness><in vivo><innovate><innovation><innovative><insight><interest><learned behavior><learning behavior><loss of function><mental illness><motivated behavior><neural circuit><neural circuitry><neural mechanism><neurocircuitry><neurological disease><neuromechanism><neuronal><neuropsychiatric disease><neuropsychiatric disorder><novel><optogenetics><pathway><post-trauma stress disorder><posttrauma stress disorder><programs><psychiatric illness><psychological disorder><response><social role><striatal><synapse><synaptic circuit><synaptic circuitry><thalamic><traumatic neurosis>
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Lisandra Flores Aldama

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Biogenesis of hERG1a/1b ion channels in health and disease model cardiomyocytes

Grant Number:

4R00HL169909-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/16/2026

End Date:

1/31/2029

Project Abstract

PROJECT SUMMARY/ABSTRACT Cardiac IKr is a critical repolarizing potassium current shaping the human ventricular action potential. It is conducted by heteromeric assemblies of the human ether-à-go-go-related gene (hERG1) 1a and 1b subunits. These subunits are encoded by alternate transcripts of the h...

Research Terms

<Action Potentials><Affect><Affinity><Arrhythmia><Behavior><Binding><Biogenesis><Bioinformatics><Biophysics><Calorimetry><Cardiac><Cardiac Abnormalities><Cardiac Arrhythmia><Cardiac Diseases><Cardiac Disorders><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cause of Death><Cell Body><Cells><Complex><DNA Helicases><DNA Unwinding Proteins><DNA mutation><DNA unwinding enzyme><Data><Defect><Disease><Disorder><Electrophysiology><Electrophysiology (science)><Ethers><FISH Technic><FISH Technique><FISH analysis><FISH assay><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><Gene Transcription><General Population><General Public><Genes><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Goals><Grant><Half-Life><HeLa><Health><Heart Abnormalities><Heart Arrhythmias><Heart Diseases><Heart Muscle Cells><Heart Vascular><Heart myocyte><Hela Cells><Hereditary><Human><Immune Precipitation><Immunoblotting><Immunoprecipitation><Impairment><In Vitro><Individual><Inherited><Ion Channel><Ionic Channels><K element><LQT2><Link><Long QT Syndrome><Mediating><Mediator><Membrane Channels><Messenger RNA><Microscopy><Modern Man><Molecular><Molecular Interaction><Mutagenesis><Mutagenesis Molecular Biology><Mutation><Myocardium><Neurophysiology / Electrophysiology><Non-Polyadenylated RNA><Origin of Life><Outcome><Patients><Phase><Post-Transcriptional Control><Post-Transcriptional Regulation><Potassium><Prevalence><Probability><Process><Proteins><RNA><RNA Expression><RNA Gene Products><RNA-Binding Proteins><Research><Ribo-seq><Ribonucleic Acid><Role><Shapes><Specificity><Structure><Sudden Death><System><Testing><Time><Transcript><Transcription><Transfection><Translations><Type 2 Long QT syndrome><United States><Ventricular><Ventricular Arrhythmia><Voltage-Gated K+ Channels><Voltage-Gated Potassium Channel><Western Blotting><Western Immunoblotting><Work><behavior in vitro><biophysical foundation><biophysical principles><biophysical sciences><cardiac muscle><cardiac rhythm><cardiomyocyte><cardiovascular disorder><career><circulatory system><design><designing><disease model><disorder model><electrophysiological><experiment><experimental research><experimental study><experiments><genome mutation><heart disorder><heart muscle><heart rhythm><helicase><hiPSC><human disease><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><hybrid protein><induced human pluripotent stem cells><insight><knock-down><knockdown><live cell image><live cell imaging><live cellular image><live cellular imaging><mRNA><mRNA Stability><mortality><mutant><novel><post-transcriptional gene regulation><posttranscriptional><protein blotting><reconstitute><reconstitution><ribosome footprint profiling><ribosome profiling><single molecule><skills><social role><structural determinants><structural factors><sudden cardiac death><synonymous mutation><translation>
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Tristan Geiller

YALE UNIVERSITY, NEW HAVEN, CT

Exploratory lead · 22/100
Recent
Active award
$248,999
FY 2026

Project Title

Dissecting the functional organization of local hippocampal circuits underlying spatial representations

Grant Number:

5R00MH129565-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

2/28/2027

Project Abstract

Project Summary The research proposed in the R00 phase will be conducted in the Department of Neuroscience at Yale University School of Medicine. The project description has been updated to reflect changes in the research from the original submission. The ability to remember past personal happenings...

Research Terms

<2-photon><AD dementia><Address><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Ammon Horn><Anatomic Sites><Anatomic structures><Anatomy><Animals><Architecture><Area><Autobiography><Award><Behavior><Behavioral><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain region><Calcium><Cell Body><Cells><Cognitive><Collection><Computer Models><Computerized Models><Connector Neuron><Cornu Ammonis><Data><Degenerative Neurologic Disorders><Development><Dorsal><Dysfunction><Electrophysiology><Electrophysiology (science)><Encephalon><Encephalon Diseases><Engineering / Architecture><Episodic memory><Event><Experimental Designs><Functional disorder><Future><Goals><Hippocampus><Human><Image><Individual><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Knowledge><Learning><Life><Maps><Measures><Mediating><Memory><Methods><Mice><Mice Mammals><Mind><Modeling><Modern Man><Molecular><Murine><Mus><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurons><Neurophysiology / Electrophysiology><Neurosciences><Optical Methods><Output><Pathway interactions><Pattern><Phase><Physiologic><Physiological><Physiopathology><Population><Primary Senile Degenerative Dementia><Process><Property><Pyramidal Cells><Pyramidal neuron><Rabies mapping><Rabies trans synaptic tracing><Rabies virus mediated mapping><Recurrence><Recurrent><Research><Research Project Summaries><Rest><Role><Shapes><Slice><Specificity><Structure><Supervision><Synapses><Synaptic><System><Testing><Time><Training><Universities><Update><Viral><Work><awake><brain behavior><cell type><cognitive function><computational modeling><computational models><computer based models><computerized modeling><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><electrophysiological><excitatory neuron><experiment><experimental analysis><experimental research><experimental study><experiments><hippocampal><hippocampal pyramidal neuron><imaging><in vivo><insight><medical college><medical schools><member><memory process><memory processing><neocortical><neural><neural circuit><neural circuitry><neurocircuitry><neurodegenerative illness><neuronal><neuropathologic><neuropathological><neuropathology><operation><operations><optogenetics><pathophysiology><pathway><post-synaptic nerves><post-synaptic neurons><postsynaptic nerves><postsynaptic neurons><presynaptic><prevent><preventing><primary degenerative dementia><rabies based mapping><rabies based retrograde mapping><rabies circuit tracing><rabies mediated retrograde monosynaptic tracing><rabies retrograde tracing><rabies tracer><rabies tracing><rabies viral tracing><rabies virus mediated circuit mapping><rabies virus monosynaptic circuit tracing><rabies virus monosynaptic tracing><rabies virus neurotracer><rabies virus retrograde tracing><rabies virus tracing><receptive field><response><school of medicine><senile dementia of the Alzheimer type><social role><synapse><synaptic circuit><synaptic circuitry><tracing with rabies><two-photon>
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Rebecca Maria Parodi-Rullan

UNIVERSITY OF PUERTO RICO MED SCIENCES, SAN JUAN, PR

Exploratory lead · 22/100
Recent
Active award
$248,999
FY 2026

Project Title

Cerebrovascular mitochondria as mediators of neuroinflammation in Alzheimer's Disease

Grant Number:

4R00AG083227-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2023

End Date:

1/31/2029

Project Abstract

ABSTRACT In Alzheimer’s Disease (AD), and to a lesser extent in non-demented individuals, deposition of amyloid β (Aβ) is found around cerebral vessels, a condition called Cerebral Amyloid Angiopathy (CAA). It is likely that the development of CAA, and consequently neurovascular unit (NVU) dysfuncti...

Research Terms

<A β-42><A β42><A-beta 42><A-beta42><AD dementia><AD pathology><AD patients><Abeta clearance><Abeta-42><Abeta42><Acceleration><Active Oxygen><Adventitial Cell><Affect><Age><Age Months><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's pathology><Alzheimer's patient><Alzheimers Dementia><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid beta-42><Amyloid beta-Protein><Amyloid beta42><Amyloid β><Amyloid β clearance><Amyloid β-42><Amyloid β-Peptide><Amyloid β-Protein><Amyloid β42><Amyloidosis><Amyloidβ-42><Amyloidβ42><Animal Model><Animal Models and Related Studies><Animals><Astrocytes><Astrocytus><Astroglia><Autoregulation><Aβ><Aβ clearance><Aβ-42><Aβ42><BBB permeabilization><BBB permeable><Behavioral><Biochemical><Bioenergetics><Bleeding><Blood - brain barrier anatomy><Blood Vessels><Blood-Brain Barrier><Brain><Brain Nervous System><Brain Vascular><Brain Vascular Disorders><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Culture Techniques><Cell Death><Cells><Cellular injury><Cerebral Amyloid Angiopathy><Cerebrovascular Disease><Cerebrovascular Disorders><Cerebrovascular system><Cerebrum><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communication><Congophilic Angiopathy><Data><Deposit><Deposition><Development><Disease><Disease Progression><Disorder><Disturbance in cognition><Dysfunction><Encephalon><Endothelial Cells><Endothelium><Event><Failure><Functional disorder><Gatekeeping><Genes><Glia><Glial Cells><Gliosis><Health><Hemato-Encephalic Barrier><Hemorrhage><Homeostasis><Hortega cell><Human><Immunofluorescence><Immunofluorescence Immunologic><Impaired cognition><In vivo analysis><Individual><Inflammation><Inflammation Mediators><Inflammatory><Inflammatory Response><Intracranial Vascular Diseases><Intracranial Vascular Disorders><Kolliker's reticulum><Link><LoxP-flanked allele><MT-bound tau><Maintenance><Mediating><Mediator><Mice><Mice Mammals><Microglia><Mitochondria><Mitochondrial DNA><Mitochondrial Swelling><Modern Man><Molecular><Movement><Murine><Mus><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neuritic Plaques><Neurocyte><Neurofibrillary Tangles><Neuroglia><Neuroglial Cells><Neuron Degeneration><Neurons><Neurovascular dysfunction><Non-neuronal cell><Nonneuronal cell><Oral Administration><Oral Drug Administration><Oxygen Radicals><Pathogenesis><Pathologic><Pathology><Pathway interactions><Pattern><Pericapillary Cell><Pericytes><Perivascular Cell><Permeability><Physiological Homeostasis><Physiopathology><Primary Senile Degenerative Dementia><Pro-Oxidants><Production><Reactive Oxygen Species><Research><Role><Rouget Cells><Rupture><Senile Plaques><Signal Pathway><Superoxide Anion><Superoxide Radical><Superoxides><Testing><Therapeutic><Variant><Variation><Vascular Diseases><Vascular Disorder><Vascular Endothelium><a beta peptide><a-beta peptide clearance><abeta><abeta accumulation><abeta aggregation><abeta deposition><abeta peptide clearance><ages><amyloid angiopathy><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid beta clearance><amyloid beta deposition><amyloid beta peptide clearance><amyloid beta plaque><amyloid disease><amyloid β accumulation><amyloid β aggregation><amyloid β deposition><amyloid-b plaque><amyloid-b protein><astrocytic glia><aβ accumulation><aβ aggregation><aβ deposition><aβ plaques><beta amyloid fibril><blood loss><blood vessel disorder><blood vessels in the brain><blood-brain barrier permeabilization><blood-brain barrier permeable><bloodbrain barrier><bloodbrain barrier permeabilization><bloodbrain barrier permeable><body movement><brain blood vessels><brain endothelial cell><brain health><brain microvascular endothelial cell><brain vascular disease><brain vascular dysfunction><brain vascular endothelial cell><brain vasculature><cell culture><cell cultures><cell damage><cell injury><cellular damage><cerebral><cerebral blood vessel><cerebral endothelial cell><cerebral microbleeds><cerebral microhemorrhage><cerebral microvascular endothelial cell><cerebral vascular><cerebral vascular disease><cerebral vascular dysfunction><cerebral vascular endothelial cell><cerebral vasculature><cerebro-vascular><cerebrovascular><cerebrovascular amyloidosis><cerebrovascular dysfunction><cerebrovascular vessels><cerebrovasculature><cognitive dysfunction><cognitive function><cognitive loss><cored plaque><cyclophilin D><cyclophilin-40><cyclosporin A-SPTP><cyclosporin A-sensitive pereability transition pore><damage to cells><developmental><diffuse plaque><effective therapy><effective treatment><experiment><experimental research><experimental study><experiments><extracellular><floxed><floxed allele><gatekeeper><gitter cell><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><hyper-phosphorylated tau><hyperphosphorylated tau><in vitro testing><in vivo><in vivo evaluation><in vivo testing><induced human pluripotent stem cells><inflammatory mediator><injury to cells><intracranial vascular dysfunction><intraoral drug delivery><mesoglia><microglial cell><microgliocyte><microtubule bound tau><microtubule-bound tau><mitochondrial><mitochondrial dysfunction><mitochondrial megachannel><mitochondrial permeability transition pore><model of animal><mtDNA><necrocytosis><nerve cement><neural degeneration><neural inflammation><neuro-vascular unit><neurodegeneration><neurodegenerative><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal><neuronal degeneration><neurovascular abnormality><neurovascular dysregulation><neurovascular impairment><neurovascular pathology><neurovascular unit><neurovasculopathy><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><non-demented><nondemented><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathophysiology><pathway><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><perivascular glial cell><prevent><preventing><primary degenerative dementia><senile dementia of the Alzheimer type><sensor><social role><soluble amyloid precursor protein><tangle><tau><tau Proteins><tau factor><tool><vascular><vascular amyloid accumulation><vascular amyloid build up><vascular amyloid deposition><vascular amyloid deposits><vascular amyloid pathology><vascular amyloidosis><vascular dysfunction><vascular inflammation><vasculopathy><τ Proteins>
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XIAO TIAN

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, LA JOLLA, CA

Exploratory lead · 22/100
Recent
Active award
$248,999
FY 2026

Project Title

Epigenetic Reprogramming to Counteract Neuronal Aging and Degeneration

Grant Number:

5R00AG068303-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2020

End Date:

1/31/2027

Project Abstract

Project Summary/Abstract The aging brain is increasingly susceptible to cognitive decline and dementia. Alzheimer’s disease (AD), a main form of dementia, is an extreme, pathological manifestation of brain aging. However, the etiology and pathogenesis of AD are not well understood, causing the deart...

Research Terms

<21+ years old><AD dementia><APP-PS1><APP/PS1><Acute><Adeno-Associated Viruses><Adult><Adult Human><Age><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amentia><Ammon Horn><Area><Award><Axon><Behavioral><Benign senescent forgetfulness><Bioinformatics><Birth><Blindness><Brain><Brain Nervous System><Brain region><Breeding><CNS Nervous System><CNS degeneration><CNS plasticity><Candidate Disease Gene><Candidate Gene><Causality><Cell Body><Cell Cycle><Cell Division Cycle><Cell Survival><Cell Viability><Cells><Central Nervous System><Characteristics><Chemicals><Chronic><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collaborations><Complex><Consultations><Cornu Ammonis><Cranial Nerve II><Crossbreeding><Crush Injury><DNA><DNA Methylation><Data><Degenerative Neurologic Disorders><Dementia><Deoxyribonucleic Acid><Dependoparvovirus><Dependovirus><Deterioration><Development Plans><Disease><Disorder><Disturbance in cognition><Ectopic Expression><Electrophysiology><Electrophysiology (science)><Encephalon><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Family Health><Family health status><Fore-Brain><Forebrain><Gene Expression><Gene Inactivation><Gene Silencing><Genetic Hybridization><Hippocampus><Histologic><Histologic Technics><Histologic Techniques><Histological Technics><Histological Techniques><Histologically><Histone Acetylation><Histones><Impaired cognition><Impairment><In Vitro><Incidence><Injury><Knowledge><Learning><Leurocristine><Link><Mammalia><Mammals><Mediating><Memory><Mentors><Mentorship><Mice><Mice Mammals><Modeling><Molecular><Murine><Mus><Nature><Nerve Cells><Nerve Degeneration><Nerve Regeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neuraxis><Neuro-regeneration><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neuronal Plasticity><Neurons><Neuropathy><Neurophysiology / Electrophysiology><Neuroregeneration><Neurosciences><Optic Nerve><Parturition><Pathogenesis><Pathologic><Patients><Phase><Physiologic><Physiological><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Predisposition><Primary Senile Degenerative Dementia><Property><Prosencephalon><Protein Modification><Public Health><RNA Seq><RNA sequencing><RNAseq><Regenerative capacity><Rejuvenation><Research><Retina><Retinal Ganglion Cells><Retrieval><Role><Second Cranial Nerve><Structure><Susceptibility><Synaptic plasticity><System><Technology><Testing><Tetracyclines><Therapeutic><Therapeutic Effect><Training><Vincristine><Vincrystine><Work><aberrant aging><abnormal aging><adeno associated virus group><adulthood><age associated cognitive impairment><age associated disease><age associated disorder><age associated impairment><age associated memory decline><age associated memory deficit><age dependent disease><age dependent disorder><age dependent impairment><age related cognitive deficit><age related cognitive dysfunction><age related cognitive impairment><age related human disease><age related memory dysfunction><age reversal><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><age-related disease><age-related disorder><age-related impairment><aged><aged brain><aged mice><aged mouse><ages><aging associated><aging brain><aging related><aging related cognitive decline><aging reversal><alleviate age related><alleviate aging><ameliorating aging><axon regeneration><axonal degeneration><axonal regeneration><behavior test><behavioral test><career development><causation><cell age><cellular age><central nervous system degeneration><central nervous system plasticity><cognitive dysfunction><cognitive function><cognitive loss><consultation><counter age related><counter aging><counteract age related><counteract aging><decline in function><decline in functional status><declining cognitive functions with aging><degenerative axon><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><disease causation><dysfunctional age related change><dysfunctional aging><effective therapy><effective treatment><elderly mice><electrophysiological><epigenetically><epigenome><epigenomics><experiment><experimental research><experimental study><experiments><functional decline><functional status decline><genome scale><genome wide analysis><genome wide studies><genome-wide><genome-wide analysis><genome-wide identification><genomewide><global gene expression><global transcription profile><hippocampal><impaired aging><improved><inhibitor><injuries><insight><maladaptive aging><medical college><medical schools><methylomics><mouse model><murine model><nerve cell death><nerve cell loss><nervous system regeneration><neural degeneration><neural plasticity><neural regeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuron cell death><neuron cell loss><neuron death><neuron loss><neuron regeneration><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><neuronal regeneration><neuronal survival><neuropathic><neurophysiological><neurophysiology><neuroplastic><neuroplasticity><neuroregenerative><novel><old mice><oxovincaleukoblastine><pathological age related changes><pathological aging><postmitotic><prevent><preventing><primary degenerative dementia><programs><regenerated nerve><regeneration ability><regeneration capacity><restore sight><restore vision><retinal ganglion><reverse age><reverse aging><reverse aging effects><reversible aging><school of medicine><senile dementia of the Alzheimer type><sight restoration><social role><therapeutic evaluation><therapeutic testing><transcriptional silencing><transcriptome><transcriptome sequencing><transcriptomic sequencing><vision loss><vision restoration><visual loss>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Michael Blatchley

SYRACUSE UNIVERSITY, SYRACUSE, NY

Exploratory lead · 22/100
Recent
Active award
$248,999
FY 2026

Project Title

4D controllable extracellular matrix properties to guide iPSC-derived intestinal organoid fate and form

Grant Number:

5R00DK135907-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Our understanding of human intestinal development is limited by a lack of tissue accessibility and limitations to existing benchtop models. These laboratory models have advanced with the emergence of organoids, which can better recapitulate the cellular composition and spat...

Research Terms

<1,2-Ethanediol><2-Hydroxyethanol><21+ years old><3-D><3-D structure><3-Dimensional><3-dimensional structure><3D><3D structure><Address><Adult><Adult Human><Amino Acids><Architecture><Atlases><Award><Benchmarking><Best Practice Analysis><Beta Cadherin-Associated Protein><Beta-1 Catenin><Biochemical><Biocompatible Materials><Bioinformatics><Biological Mimetics><Biology><Biomaterials><Biomimetics><Blood Vessels><Body Tissues><CUL-2><Cancers><Capsules><Cell Body><Cell Communication and Signaling><Cell Shape><Cell Signaling><Cell-Extracellular Matrix><Cells><Cellular Matrix><Cellular Mechanotransduction><Clinical><Complex><Complex Mixtures><Consult><Cues><Cytoskeletal System><Cytoskeleton><Development><Developmental Biology><Differentiation in cell culture><Dihydroxyethanes><Dimensions><Disease><Disorder><Dose><ECM><Engineering><Engineering / Architecture><Epithelium><Ethanediols><Ethylene Glycols><Exposure to><Extracellular Matrix><Extracellular Matrix Proteins><Fluorescence><Frequencies><Future><GI Stem cell><Generalized Growth><Generations><Geometry><Germ Layers><Global Change><Growth><HG38><Human><Human Development><Human Figure><Human body><Hydrogels><Image><Image Analyses><Image Analysis><Imaging Procedures><Imaging Technics><Imaging Techniques><In Vitro><In vitro cell differentiation><Integrin Binding><Intestinal><Intestines><Intracellular Communication and Signaling><Investigators><Kidney><Kidney Urinary System><LGR5><LGR5 gene><Label><Laboratories><Lead><Learning><Light><Malignant Neoplasms><Malignant Tumor><Measures><Mechanical Signal Transduction><Mechanics><Mechanosensory Transduction><Mentors><Mesenchymal><Mesenchymas><Mesenchyme><Metabolic><Methods><Mice><Mice Mammals><Microscopy><Modeling><Modern Man><Monoethylene Glycol><Morphogenesis><Murine><Mus><Nerve><Nuclear><Organ><Organoids><PRO2286><Patients><Pattern><Pb element><Phase><Phenotype><Photoradiation><Population><Property><Proteins><Protocol><Protocols documentation><Reporter><Research><Research Personnel><Researchers><Rheology><Role><Signal Transduction><Signal Transduction Systems><Signaling><Source><Specific qualifier value><Specificity><Specified><Spectroscopy><Spectrum Analyses><Spectrum Analysis><Techniques><Time><Tissue Growth><Tissues><Training><Villus><adulthood><age associated effects><age effect><age related effects><aging effect><aminoacid><benchmark><beta cat><beta catenin><biological material><biological signal transduction><bowel><capsule><cell fate specification><consults><design><designing><developmental><developmental disease><developmental disorder><differentiation in culture><differentiation in vitro><differentiation protocol><directed differentiation><disease model><disorder model><ethylene glycol><fetal><gastrointestinal stem cell><gene signatures><genetic signature><gut progenitor><gut stem cell><heavy metal Pb><heavy metal lead><hiPSC><human derived model><human derived platform><human derived system><human disease><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human like model><human like platform><human like system><human model><human specific alternative><human specific model><human specific platform><human specific system><human-based alternative><human-based biological models><human-based model><human-based nonanimal models><human-based platform><human-based research><human-based system><human-based tools><human-centered model><human-centered platform><human-centered research><human-centered system><human-focused research><human-relevant alternative><human-relevant model><human-relevant platform><human-relevant system><iPS><iPSC><iPSCs><image evaluation><image interpretation><imaging><impact of age><implantation><improved><in vitro Model><in vitro cellular differentiation><in vivo><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><influence of age><integrin bound><intestinal crypt><intestinal progenitor><intestinal stem cells><intracellular skeleton><malignancy><matrigel><mechanic><mechanical><mechanical properties><mechanosensing><mechanotransduction><model of human><morphogenetic process><neoplasm/cancer><notch><notch protein><notch receptors><ontogeny><programs><renal><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><spatial and temporal><spatial temporal><spatiotemporal><stem cell organoids><stem cell-derived organoids><three dimensional><three dimensional structure><translational opportunities><translational potential><vascular><β-catenin>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Senthil Velan Bhoopalan

ST. JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN

Exploratory lead · 22/100
Recent
Active award
$248,999
FY 2026

Project Title

Hematopoietic stem cell defects in Diamond-Blackfan Anemia

Grant Number:

4R00DK134844-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

2/28/2029

Project Abstract

(PLEASE KEEP IN WORD, DO NOT PDF) Diamond-Blackfan anemia (DBA) is a rare inherited bone marrow failure disorder caused mainly by heterozygous loss-of-function mutations in 24 out of 83 ribosomal protein genes, with RPS19 being the most commonly affected gene. DBA usually presents with isolated eryt...

Research Terms

<0-11 years old><Acceleration><Address><Affect><Allelic Loss><Allo BMT><Allogeneic BMT><Allogeneic Bone Marrow Transplantation><Anemia><Animal Model><Animal Models and Related Studies><Antioncogene Protein p53><Assay><Bioassay><Biological Assay><Biology><Blood><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Bone Marrow><Bone Marrow Grafting><Bone Marrow Reticuloendothelial System><Bone Marrow Transplant><Bone Marrow Transplantation><Bone marrow failure><CD34><CD34 gene><CITE sequencing><CITE-seq><CITEseq><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CUT&RUN><Cas nuclease technology><Cell Body><Cells><Cellular Indexing of Transcriptomes and Epitopes by Sequencing><Cellular Tumor Antigen P53><Child><Child Youth><Children (0-21)><Chronic><Cleavage Targets and Release Using Nuclease><Cleavage Under Targets and Release Using Nuclease><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complex><DNA Therapy><DNA mutation><Data><Defect><Development><Diamond-Blackfan anemia><Disease><Disorder><Dysfunction><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Erythrocyte Transfusion><Erythroid><Erythropoiesis><Exhibits><Experimental Models><Failure><Foundations><Functional disorder><Funding><Future><Gene Expression><Gene Proteins><Gene Transcription><Gene Transfer Clinical><Genes><Genetic Change><Genetic Intervention><Genetic Transcription><Genetic defect><Genetic mutation><Glucocorticoids><Goals><HDM2><HPCA1><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Heterograft><Heterologous Transplantation><Heterozygote><Human><Immune Precipitation><Immunoblotting><Immunodeficient Mouse><Immunoprecipitation><Impairment><In Vitro><Inherited bone marrow failure><Investigation><Loss of Heterozygosity><MDM2><MDM2 gene><MDMX protein><Maintenance><Maps><Marrow Transplantation><Mdm-2 protein><Mediating><Modern Man><Molecular><Mutation><Myelopoiesis><NIH><National Institutes of Health><Oncoprotein MDM2><Oncoprotein p53><P53><Pathway interactions><Patients><Phenotype><Phosphoprotein P53><Phosphoprotein pp53><Physicians><Physiology><Physiopathology><Polycomb><Population><Population Heterogeneity><Process><Production><Protein Deficiency><Protein Gene Products><Protein Subunits><Protein TP53><RNA Expression><RNA Seq><RNA sequencing><RNAseq><RPS19><RPS19 gene><Red Blood Cell Transfusion><Repression><Repressor Proteins><Research><Ribo-seq><Ribonucleoproteins><Ribosomal Proteins><Ribosomal RNA><Ribosomes><Scientist><Spectroscopy><Spectrum Analyses><Spectrum Analysis><Structure><TP53><TP53 gene><TRP53><Testing><Therapeutic><Training><Transcription><Translations><Transplantation><Tumor Protein p53><Tumor Protein p53 Gene><Ubiquitin Ligase Component Gene><Ubiquitin Ligase Gene><United States National Institutes of Health><Western Blotting><Western Immunoblotting><Xenograft><Xenograft procedure><Xenotransplantation><allogeneic bone marrow transplant><allogenic bone marrow transplant><blood cell formation><blood cell progenitor><blood disorder><blood formation><blood progenitor><blood stem cell><blood-forming stem cell><bone marrow allograft><bone marrow failure syndrome><career><cellular indexing of transcriptomes and epitopes by single cell sequencing><cofactor><cytopenia><deficiency of protein><developmental><diverse populations><effective therapy><effective treatment><elderly patient><epigenetically><erythroid development><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genome mutation><genomic therapy><global gene expression><global transcription profile><hematopoietic differentiation><hematopoietic hierarchy><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><heterogeneous population><heterozygosity><human derived model><human derived platform><human derived system><human like model><human like platform><human like system><human model><human specific alternative><human specific model><human specific platform><human specific system><human-based alternative><human-based biological models><human-based model><human-based nonanimal models><human-based platform><human-based research><human-based system><human-based tools><human-centered model><human-centered platform><human-centered research><human-centered system><human-focused research><human-relevant alternative><human-relevant model><human-relevant platform><human-relevant system><improved><in vivo><infancy><infantile><inherited disease of bone marrow failure><insight><kids><loss of function mutation><mdm-2 oncogene protein><mdm2 protein><model of animal><model of human><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><older patient><p53 Antigen><p53 Genes><p53 Tumor Suppressor><p53-Binding Protein MDM2><pathophysiology><pathway><population diversity><progenitor><progenitor biology><progenitor cell biology><progenitor cell function><progenitor cell maintenance><progenitor function><progenitor maintenance><programs><protein blotting><protein p53><rRNA><repressor complex><ribosome footprint profiling><ribosome profiling><ribosomopathy><scRNA sequencing><scRNA-seq><self-renew><self-renewal><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><stem and progenitor biology><stem and progenitor cell function><stem and progenitor function><stem cell biology><stem cell function><stem cell maintenance><transcriptome><transcriptome sequencing><transcriptomic sequencing><transcriptomics><translation><translatome><transplant><transplant therapy><transplant treatment><transplantation therapy><transplantation treatment><ubiquitin ligase><xeno-transplant><xeno-transplantation><youngster>
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Juliet Goldsmith

THOMAS JEFFERSON UNIVERSITY, PHILADELPHIA, PA

Exploratory lead · 22/100
Recent
Active award
$248,998
FY 2026

Project Title

Inflammation and plaque formation downstream of disrupted autophagy in Alzheimer's disease

Grant Number:

5R00NS133611-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/3/2024

End Date:

11/30/2027

Project Abstract

Alzheimer’s disease and related dementias (AD/ADRD) are devastating diseases to those diagnosed and come with a high cost to society. Reliable early identification and improved intervention is vital to treat patients before neuronal loss is irreversible. Autophagy is strongly implicated in the progr...

Research Terms

<AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><ADRD><APOE e4><APOE-ε4><APOEε4><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's precursor protein><Alzheimers Dementia><Amyloid A4 Protein Precursor><Amyloid Protein Precursor><Amyloid beta-Protein Precursor><Amyloid β-Protein Precursor><Autophagocytosis><Autophagosome><Autoregulation><Award><Biochemical><Brain><Brain Nervous System><Cell Body><Cell Communication><Cell Interaction><Cell model><Cell-to-Cell Interaction><Cells><Cellular model><Chronic><Co-culture><Cocultivation><Coculture><Coculture Techniques><Communication><Complement><Complement Proteins><Complex><DNA Molecular Biology><DNA mutation><Data><Deposit><Deposition><Diagnosis><Diagnostic><Disease><Disease Progression><Disorder><Drug Design><Drug Targeting><Dynein><Dynein ATPase><Dynein Adenosine Triphosphatase><Dynein Adenosinetriphosphatase><Early identification><Encephalon><Endoplasmic Reticulum><Ergastoplasm><Foundations><Genetic><Genetic Change><Genetic defect><Genetic mutation><Health><Homeostasis><Hortega cell><Immune><Immunes><Impairment><In Vitro><Induced pluripotent stem cell derived neurons><Inflammation><Inflammatory><Intervention><MT-bound tau><Maintenance><Micro-tubule><Microglia><Microtubules><Mitochondria><Mitochondrial DNA><Modeling><Molecular><Molecular Biology><Mutation><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocyte><Neurofibrillary Tangles><Neuron Degeneration><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neurons><Organelles><Pathway interactions><Patients><Phase><Phenotype><Physiological Homeostasis><Postdoc><Postdoctoral Fellow><Primary Senile Degenerative Dementia><Process><Protein Secretion><Proteins><Reproducibility><Research><Research Associate><Risk-associated variant><Role><Sampling><Societies><Stress><Supporting Cell><Synapses><Synaptic><System><Tau forming aggregates><Techniques><Variant><Variation><Work><aberrant tau><aberrant tau protein><abnormal tau><abnormal tau protein><abnormally aggregated tau protein><aggregation in tau><aging associated><aging related><alzheimer risk><amyloid precursor protein><apo E-4><apo E4><apo epsilon4><apoE epsilon 4><apoE-4><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-4><apolipoprotein E4><autophagy><brain cell><cell type><complementation><cost><early biomarkers><early detection biomarkers><early detection markers><experiment><experimental research><experimental study><experiments><filamentous tau inclusion><genome mutation><gitter cell><glial activation><glial cell activation><high resolution imaging><iPS><iPS neurons><iPSC><iPSC derived-neurons><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell neurons><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><mesoglia><microglial cell><microgliocyte><microtubule associated protein tau aggregation><microtubule associated protein tau deposit><microtubule associated protein tau mutation><microtubule bound tau><microtubule-associated protein tau mutation><microtubule-bound tau><mitochondrial><mtDNA><mutant tau><mutant tau protein><mutation in microtubule associated protein tau><mutation in microtubule-associated protein tau><nerve cell death><nerve cell loss><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neuroinflammation><neuroinflammatory><neurological degeneration><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><neurons derived from induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><new drug target><new druggable target><new marker><new pharmacotherapy target><new therapeutic target><new therapy target><novel biomarker><novel drug target><novel druggable target><novel marker><novel pharmacotherapy target><novel therapeutic target><novel therapy target><paired helical filament of tau><pathogenic tau><pathogenic tau gene mutation><pathogenic tau protein><pathological change in tau><pathological tau><pathological tau protein><pathway><perivascular glial cell><pharmacologic><post-doc><post-doctoral><post-doctoral trainee><prevent><preventing><primary degenerative dementia><rational design><research associates><risk allele><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk gene><risk genotype><risk loci><risk locus><risk of developing Alzheimer's><risk variant><self-aggregate tau><senile dementia of the Alzheimer type><social role><spatial and temporal><spatial temporal><spatiotemporal><stressor><synapse><tangle><tau><tau PHF><tau Proteins><tau abnormality><tau accumulation><tau aggregate><tau aggregation><tau factor><tau fibrillation><tau fibrillization><tau filament><tau inclusion><tau intronic mutation><tau mutation><tau neurofibrillary tangle><tau oligomer><tau paired helical filament><tau pathological change><tau polymerization><tau protein accumulation><tau protein aggregation><tau-tau interaction><therapeutic target><trafficking><τ Proteins><τ aggregation><τ mutation>
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Amelia Cuarenta

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Exploratory lead · 22/100
Recent
Active award
$248,997
FY 2026

Project Title

Early resource scarcity effects on addiction-related behavior: a novel role for retrotransposons.

Grant Number:

4R00DA060266-02

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2024

End Date:

3/31/2029

Project Abstract

Project Summary/Abstract DNA is generally thought of as stable. However, retrotransposons are mobile elements that result in new copy insertions in DNA. Emerging evidence suggests retrotransposons can be affected by changes in the environment, suggesting a novel mechanism by which exposure to early ...

Research Terms

<21+ years old><Address><Adolescent><Adolescent Youth><Adult><Adult Human><Adverse Experience><Adverse event><Affect><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Astrocytes><Astrocytus><Astroglia><Beds><Behavior><Behavior-Related Disorder><Behavior-Related Problem><Behavioral><Brain><Brain Nervous System><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Common Rat Strains><DNA><DNA Molecular Biology><DNA Sequence><DNA Transposable Elements><Data><Deoxyribonucleic Acid><Development><Drugs><Ecological impact><Elements><Encephalon><Environment><Environmental Impact><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Event><Exposure to><Female><Foundations><Future><Genome><Genomics><Glia><Glial Cells><Goals><Human Genome><Impoverished><Impulsive Behavior><Impulsivity><Infumorph><Intercistronic Region><Intergenic Regions><Intervention><Kadian><Knowledge><Kolliker's reticulum><Learning><Length><Life><Lifestyle-Related Disorder><Lifestyle-Related Problem><Lifestyle-related condition><Location><Long Interspersed Elements><MS Contin><MSir><Magnetism><Mediating><Medication><Mental disorders><Mental health disorders><Mentors><Modeling><Molecular Biology><Molecular Genetics><Morphia><Morphine><Neonatal><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuroendocrinology><Neuroglia><Neuroglial Cells><Neurons><Neurosciences><Non-neuronal cell><Nonneuronal cell><Odors><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><Oramorph><Oramorph SR><Paste substance><Pastes><Pathway interactions><Pharmaceutical Preparations><Phase><Play><Poverty><Psychiatric Disease><Psychiatric Disorder><Rat><Rats Mammals><Rattus><Research><Research Resources><Resources><Retrotransposition><Retrotransposon><Rewards><Risk><Role><Roxanol><Self Administered><Self Administration><Statex SR><Stress><Substance Use Disorder><Techniques><Testing><Training><Transposable Elements><addiction><addictive disorder><adulthood><amygdaloid nuclear complex><astrocytic glia><build resilience><build resiliency><cell sorting><cell type><compare to control><comparison control><develop resilience><develop resiliency><developmental><drug/agent><early adversity><early childhood adversity><early experience><early life adversity><early life stress><enhance resilience><enhance resiliency><epigenetically><experiment><experimental research><experimental study><experiments><facilitate resilience><gene network><genetic approach><genetic strategy><human whole genome><improve resilience><improve resiliency><increase resilience><increase resiliency><innovate><innovation><innovative><insight><intervention design><juvenile><juvenile human><knock-down><knockdown><later in life><later life><magnetic><male><mental illness><nerve cement><neuronal><neuropsychiatric disease><neuropsychiatric disorder><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><programs><promote resilience><promote resiliency><psychiatric illness><psychological disorder><resilience><resilience development><resilient><reward circuitry><rodent genome><social role><substance use and disorder><substance use treatment><therapy design><timeline><tool><treatment design><♀><♂>
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Jonathan Tang

SEATTLE CHILDREN'S HOSPITAL, SEATTLE, WA

Exploratory lead · 22/100
Recent
Active award
$248,995
FY 2026

Project Title

Dissecting the Action Learning Process with Dopaminergic Reinforcement

Grant Number:

5R00NS112575-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2019

End Date:

2/28/2027

Project Abstract

Understanding the process by which animals learn to perform specific actions from rewarding experiences is important for identifying the neural and behavioral patterns that indicate system dysregulation; such knowledge can help lead to the development of diagnostics and therapy for conditions where ...

Research Terms

<Address><Affect><Amentia><Animals><Area><Behavior><Behavioral><Behavioral Mechanisms><Behavioral Paradigm><Brain><Brain Nervous System><Cell Communication and Signaling><Cell Signaling><Computing Methodologies><Corpus Striatum><Corpus striatum structure><Cues><DA Neuron><Data><Dementia><Dissection><Dopamine neuron><Dopaminergic Cell><Dorsal><Encephalon><Environment><Faculty><Genetic><Goals><History><Huntington Chorea><Huntington Disease><Huntington's><Huntington's Disease><Huntingtons Disease><Image><Impairment><Instrumental Learning><Intracellular Communication and Signaling><Joints><Knowledge><Label><Lead><Learning><Life><Mammalia><Mammals><Mechanisms of Behavior and Behavior Change><Mediating><Mentors><Mentorship><Methods><Mice><Mice Mammals><Modeling><Monitor><Motor><Movement><Murine><Mus><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic><Neurologic Disorders><Neurological><Neurological Disorders><Neurons><Neurosciences><Operant Conditioning><Paralysis Agitans><Parkinson><Parkinson Disease><Pathway interactions><Pattern><Pb element><Performance><Phase><Population><Position><Positioning Attribute><Primary Parkinsonism><Process><Psychological reinforcement><Recording of previous events><Reinforcement><Research><Resolution><Resource Development><Rewards><Role><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Striate Body><Striatum><Substantia Nigra><Substantia nigra structure><System><Technical Expertise><Techniques><Testing><Training><Universities><Ventral Striatum><Ventral Tegmental Area><Viral><Work><behavior influence><behavior mechanism><behavior response><behavior study><behavioral influence><behavioral response><behavioral study><biological signal transduction><body movement><career development><computational methodology><computational methods><computer based method><computer methods><computing method><diagnostic approach><diagnostic development><diagnostic strategy><dopaminergic neuron><experience><experiment><experimental research><experimental study><experiments><genetic approach><genetic strategy><heavy metal Pb><heavy metal lead><histories><imaging><instrumental conditioning><learning activity><learning method><learning strategies><learning strategy><neural><neural correlate><neural mechanism><neurological disease><neuromechanism><neuronal><optogenetics><pars compacta><pathway><programs><reinforced behavior><resolutions><response><sequence learning><social role><striatal><technical skills><tool><treatment strategy><ventral tegmentum>
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Thoa Khuu

UNIVERSITY OF COLORADO, Boulder, CO

Exploratory lead · 22/100
Recent
Active award
$248,995
FY 2026

Project Title

Adolescent Friendship Networks: Effects on Immigrant Youth’s Psychosocial Health

Grant Number:

4R00HD114887-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/12/2026

End Date:

12/31/2028

Project Abstract

PROJECT ABSTRACT The proposed research will assess the impact adolescent friendship networks have on the psychosocial health of immigrant youth (i.e., the 1st and 2nd generation). Immigrant youth are a vulnerable population, with disproportionately high prevalence of adverse psychosocial health out...

Research Terms

<0-11 years old><12-20 years old><Address><Adolescence><Adolescent><Adolescent Development><Adolescent Youth><Affect><Anxiety><Anxiety Disorders><Applications Grants><Area><Asian><Child><Child Youth><Children (0-21)><Communities><Complement><Complement Proteins><Data><Data Collection><Data Set><Destinations><Development><Disparities><Disparity><Education><Educational aspects><Emotional Depression><Empirical Research><Face><Family><Friends><Friendships><Generations><Goals><Grant><Grant Proposals><Health><Heterogeneity><High Prevalence><Immigrant><Individual><Investigation><Investigators><Knowledge><Lead><Life><Literature><Longitudinal Studies><Longitudinal Surveys><Measures><Mediating><Mental disorders><Mental health disorders><Methods><Moods><Nature><Network Analysis><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Outcome><PTSD><Pathway Analysis><Pattern><Pb element><Personal Satisfaction><Phase><Population><Position><Positioning Attribute><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Process><Psychiatric Disease><Psychiatric Disorder><Psychometrics><Refugees><Research><Research Personnel><Researchers><Risk><Role><Sampling><Schools><Shapes><Social Environment><Social Network><Sociology><Survey Instrument><Surveys><Testing><Time><Training><United States><Vulnerable Populations><Youth><Youth 10-21><adolescence (12-20)><adolescent health><analytical method><authority><career><complementation><data resource><depression symptom><depressive><depressive symptoms><design><designing><developmental><ethnoracial minority><experience><faces><facial><forging><health outcome disparity><health outcome inequality><health outcome inequity><heavy metal Pb><heavy metal lead><inequitable health outcome><insight><juvenile><juvenile human><kids><long-term study><longitudinal outcome studies><longitudinal research study><mental illness><method development><network models><peer><post-trauma stress disorder><posttrauma stress disorder><psychiatric illness><psychologic><psychological><psychological disorder><psychosocial><self esteem><social climate><social context><social integration><social role><socioenvironment><socioenvironmental><traumatic neurosis><unequal health outcome><vulnerable group><vulnerable individual><vulnerable people><well-being><wellbeing><youngster><youth age>
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Lianlian Lei

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Exploratory lead · 22/100
Recent
Active award
$248,976
FY 2026

Project Title

Older Adults Living with Dementia and Their Informal Caregivers: Reciprocal Impacts of Caregiving and Serious Illness on Health Care Outcomes

Grant Number:

5R00AG075145-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/10/2022

End Date:

2/28/2027

Project Abstract

PROJECT SUMMARY Alzheimer’s disease and other dementias are a growing public health concern, currently affecting nearly 8 million older adults and 16 million informal caregivers in the U.S. Informal caregiving—unpaid care by family members or friends—for persons living with dementia (PLWD) is unique...

Research Terms

<AD dementia><Adverse effects><Affect><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amentia><Apoplexy><Applications Grants><Area><Attention><Award><Behavior><Brain Vascular Accident><Cardiac infarction><Care Givers><Care giver intervention><Caregivers><Caring><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Chronic><Circulatory Collapse><Clinical><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complex><Contracting Opportunities><Contracts><Data><Data Analytics><Daughter><Dementia><Dementia caregivers><Deterioration><Disease><Disorder><Disturbance in cognition><ED visit><ER visit><Econometric Models><Economics><Emergency care visit><Emergency department visit><Emergency hospital visit><Emergency room visit><Emotional><Exposure to><Family member><Foundations><Friends><Funding><Future><Gatekeeping><Geriatric Psychiatry><Goals><Grant Proposals><Health><Health Care><Health Care Systems><Health Care Utilization><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Health Promotion><Health Services><Health Services Evaluation><Health Services Research><Health Status><Health and Retirement Study><Hip Fractures><Hospital Admission><Hospitalization><Hour><Impaired cognition><Impairment><Informal care giver><Informal care giving><Intervention><Investigators><Knowledge><Leadership><Level of Health><Light><Link><Long-Term Care><Longitudinal Studies><Longitudinal Surveys><Marketing><Married Persons><Medical><Medical Care Research><Medicare><Medicare claim><Mentorship><Methodology><Methods><Modeling><Morbidity><Myocardial Infarct><Myocardial Infarction><Out-patients><Outcome><Outpatients><Pathway interactions><Personal Satisfaction><Persons><Phase><Photoradiation><Pneumonia><Policies><Population><Primary Senile Degenerative Dementia><Professional Competence><Psychiatry for older adults><Psychiatry for older people><Psychiatry for seniors><Psychiatry for the elderly><Psychogeriatrics><Public Health><Research><Research Personnel><Researchers><Salutogenesis><Self Care><Shock><Solid><Source><Spouses><Stroke><Survey Instrument><Surveys><Title 18><Training><Visit><Wife><Work><ages><brain attack><cardiac infarct><care costs><care giving><care outcomes><career><career skill><caregiver interventions><caregivers for persons living with dementia><caregivers for persons with dementia><caregivers of individuals with dementia><caregivers of patients with dementia><caregiving><cerebral vascular accident><cerebrovascular accident><circulatory shock><cognitive dysfunction><cognitive loss><coronary attack><coronary infarct><coronary infarction><cost><death risk><decline in function><decline in functional status><dementia care giver><economic><experience><extended care><functional decline><functional status decline><gatekeeper><geriatric psychology><geropsychiatry><geropsychology><geropsychopharmacology><health care outcomes><health care service use><health care service utilization><health insurance for disabled><health level><heart attack><heart infarct><heart infarction><high risk><high risk group><high risk individual><high risk people><high risk population><informal care><informal caregiver><informal caregiving><innovate><innovation><innovative><long-term study><longitudinal outcome studies><longitudinal research study><member><mortality risk><older adult><older adulthood><pathway><personal care><pressure><primary degenerative dementia><programs><promoting health><senile dementia of the Alzheimer type><services research><shocks><skills><stroked><strokes><trend><well-being><wellbeing>
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Catherine Cioffi Cohen

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 22/100
Recent
Active award
$248,965
FY 2026

Project Title

Pancreatic fat and volume and childhood metabolic health

Grant Number:

4R00DK136503-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2029

Project Abstract

PROJECT SUMMARY/ABSTRACT The rise of type 2 diabetes (T2D) in U.S. youth is an alarming public health issue. Although obesity is a strong risk factor for pediatric T2D, at the same time, only a subset of youth with obesity develops T2D, suggesting disease pathogenesis is driven by factors beyond tot...

Research Terms

<0-11 years old><12-20 years old><Abdomen><Adolescence><Adolescent><Adolescent Youth><Adult-Onset Diabetes Mellitus><Age><Autoregulation><Award><BMI><BMI percentile><BMI z-score><Birth><Body Composition><Body fat><Body mass index><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Clinical><Cohort Studies><Colorado><Complement><Complement Proteins><Complex><Cross-Sectional Studies><Cross-Sectional Survey><D-Glucose><Data><Dextrose><Diet><Disease><Disease Frequency Surveys><Disorder><Doctor of Philosophy><Dysfunction><Enrollment><Environment><Ethnic Origin><Ethnicity><Fats><Fatty Liver><Fatty acid glycerol esters><Functional disorder><Funding><Generalized Growth><Gestation><Glucose><Goals><Growth><Growth Agents><Growth Factor><Growth Substances><Health><Hepatic><Heterogeneity><Homeostasis><Hour><Human><Humulin R><Image><Individual><Infant><Insulin><Insulin homeostasis><Joints><Ketosis-Resistant Diabetes Mellitus><Knowledge><Life Cycle><Life Cycle Stages><Life course epidemiology><Lifecourse epidemiology><Lipid Trafficking><Liver Steatosis><MR Imaging><MR Tomography><MRI><MRI Scans><MRIs><Magnetic Resonance Imaging><Magnetic Resonance Imaging Scan><Malnutrition><Maturity-Onset Diabetes Mellitus><Measures><Mediating><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mentors><Mentorship><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic dysfunction><Modern Man><Mothers><NIDDM><NMR Imaging><NMR Tomography><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Novolin R><Nuclear Magnetic Resonance Imaging><Nutrition><Nutritional><Nutritional Deficiency><OGTT><Obesity><Observational research><Onset of illness><Oral Glucose Tolerance Test><Overnutrition><Pancreas><Pancreatic><Parents><Parturition><Pathogenesis><Pathway interactions><Ph.D.><PhD><Phase><Physiologic><Physiological><Physiological Homeostasis><Physiopathology><Play><Population><Pregnancy><Pregnant Women><Preventative strategy><Prevention strategy><Preventive strategy><Prospective Studies><Proteins Growth Factors><Puberty><Public Health><Quetelet index><Regular Insulin><Research><Research Activity><Risk><Risk Factors><Risk Marker><Role><Scanning><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><T2 DM><T2D><T2DM><Thesaurismosis><Time><Tissue Growth><Training><Training Activity><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Undernutrition><Variant><Variation><Visceral><Visit><Youth><Youth 10-21><Zeugmatography><abdominal adiposity><abdominal fat><adiposity><adolescence (12-20)><adult onset diabetes><ages><birth cohort study><birth cohort survey><child adiposity><child obesity><childhood adiposity><childhood obesity><cohort><cohort research study><cohort survey><complementation><corpulence><cross-sectional research study><demographics><design><designing><dietary deficiency><diets><disease onset><disorder onset><early adolescence><early onset><enroll><expectant mother><expectant women><expecting mother><expecting women><experience><falls><hepatic steatosis><hepatosteatosis><imaging><improved><indexing><individuals who are pregnant><infancy><infantile><insight><insulin balance><insulin control><inter-individual variability><inter-individual variation><investigate observational><juvenile><juvenile human><ketosis resistant diabetes><kids><life course><lipid transport><malnourished><maturity onset diabetes><metabolism disorder><nutrition deficiency><nutrition deficiency disorder><nutritional deficiency disorder><nutritious><obese children><obesity during childhood><obesity in children><observational investigation><offspring><ontogeny><parent><parent grant><pathophysiology><pathway><pediatric><pediatric obesity><people who are pregnant><postnatal><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal><prevent><preventing><programs><prospective research study><prospective survey><prospective test><risk predictor><risk predictors><sex><skill acquisition><skill development><skills><social role><study observational><survey observational><those who are pregnant><trafficking><training module><trait><trend><type 2 DM><type II DM><type two diabetes><unborn><women who are pregnant><youngster><youth age>
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Y Hoang

UPSTATE MEDICAL UNIVERSITY, SYRACUSE, NY

Exploratory lead · 22/100
Recent
Active award
$248,950
FY 2026

Project Title

Quality Control and Spatial Regulation of Bacterial Condensates

Grant Number:

4R00GM157383-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

2/28/2029

Project Abstract

Condensates play a crucial role in spatially organizing and regulating biochemical reactions within cells. Dynamic condensates arise from phase separation, while insoluble aggregates result from protein misfolding. Although both can manifest as fluorescent foci in bacterial cells, they exhibit disti...

Research Terms

<Address><Affect><Bacteria><Biochemical><Biochemical Reaction><Biologic Models><Biological Models><Biotech><Biotechnology><CO2><Carbon Dioxide><Carbonic Anhydride><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell division><Cells><Cellular Expansion><Cellular Function><Cellular Growth><Cellular Inclusions><Cellular Physiology><Cellular Process><Chaperone><Communicable Diseases><Data><Development><Disease><Disorder><Drug Delivery><Drug Delivery Systems><E coli><E. coli><Engineering><Environment><Enzymatic Reaction><Escherichia coli><Esteroproteases><Exclusion><Exhibits><Fixation><Foundations><Gel><Goals><Health><Human><Impairment><Inclusion Bodies><Infectious Diseases><Infectious Disorder><Intervention><Knowledge><Liquid substance><Maintenance><Metabolic><Methods><Microscopy><Model System><Modern Man><Molecular><Molecular Chaperones><Organelles><Pathogenesis><Peptidases><Peptide Hydrolases><Phase><Physical condensation><Play><Position><Positioning Attribute><Process><Productivity><Protease Gene><Proteases><Proteinases><Proteins><Proteolytic Enzymes><Publications><Publishing><Quality Control><Regulation><Research><Role><Scientific Publication><Solid><Stress><Structure><Subcellular Process><System><Techniques><Testing><Therapeutic><Work><aberrant folded protein><aberrant folded proteins><aberrant protein folding><abnormal folded protein><abnormal folded proteins><abnormal protein folding><biophysical characteristics><biophysical characterization><biophysical measurement><biophysical parameters><biophysical properties><cell growth><condensation><design><designing><developmental><fluid><fluidity><health application><improved><innovate><innovation><innovative><insoluble aggregate><liquid><microbial><misfolded protein><misfolded proteins><nano meter scale><nano meter sized><nanometer scale><nanometer sized><nanoscale><pathologic protein folding><post-doctoral training><programs><protein aggregate><protein aggregation><protein complex><protein misfolding><protein purification><proteotoxic protein><proteotoxin><reconstitute><reconstitution><sample fixation><single molecule><social role><superresolution imaging><synthetic biology><therapeutic agent development><therapeutic development><therapeutic target><tool>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Kaitlyn K Stanhope

EMORY UNIVERSITY, ATLANTA, GA

Exploratory lead · 22/100
Recent
Active award
$248,915
FY 2026

Project Title

Accumulation of stress and trauma across the life course and cardiometabolic risk during pregnancy and postpartum

Grant Number:

5R00HL161355-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/5/2024

End Date:

1/31/2027

Project Abstract

Project Abstract In the United States, at least 1 in 10 pregnant people experience a cardiometabolic disorder of pregnancy each year such as a hypertensive disorder of pregnancy (HDP; 6-8%) or gestational diabetes (GDM; 2-10%). Either diagnosis is associated with increased risk of maternal morbidity...

Research Terms

<21+ years old><Access to Care><Active Follow-up><Adult><Adult Human><BMI><BMI percentile><BMI z-score><Behavior><Biological Markers><Black><Black race><Blood><Blood Pressure><Blood Reticuloendothelial System><Body Weight decreased><Body mass index><Cardiometabolic Disease><Cardiometabolic Disorder><Cardiovascular Diseases><Childhood><Clinic><Clinical><Communities><Data><Data Collection><Data Set><Development><Diagnosis><Discipline of obstetrics><Disparity population><Dysfunction><Economic Income><Economical Income><Emotional Depression><Environment><Epidemiology><Exposure to><Face><Family><Functional disorder><Gestation><Gestational Diabetes><Gestational Diabetes Mellitus><Goals><Health><Health Services Accessibility><History><Hypertension-Associated Pregnancy Disorder><Income><Individual><Lactation><Life Cycle><Life Cycle Stages><Life Stress><Lipids><Longitudinal Studies><Longitudinal Surveys><Low income><Maternal Mortality><Measurement><Measures><Mediation><Medical><Medical Records><Mentors><Mentorship><Metabolic><Modeling><Modification><Negotiating><Negotiation><Neighborhoods><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Obstetrics><Outcome><PTSD><Participant><Pattern><Perinatal><Peripartum><Phase><Physiopathology><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Post-partum Women><Postpartum Period><Postpartum Women><Posttraumatic Neuroses><Pregnancy><Pregnancy Complications><Pregnancy Histories><Pregnancy-Induced Diabetes><Pregnant Women><Preventative strategy><Prevention strategy><Preventive strategy><Prospective, cohort study><Questionnaires><Quetelet index><Recording of previous events><Registries><Research><Risk><Risk Behaviors><Risk Factors><Risky Behavior><Role><SES disparity><Sampling><Secondary Prevention><Social support><Stress><Survey Instrument><Surveys><Symptoms><Time><Training><Trauma><United States><Urine><Weight Loss><Weight Reduction><Woman><access to health services><access to services><access to treatment><accessibility to health services><active followup><adulthood><adverse pregnancy outcome><after pregnancy><at risk behavior><availability of services><bear children><bearing children><before conception><bio-markers><biologic marker><biological adaptation to stress><biomarker><body weight loss><cardiometabolic><cardiometabolic risk><cardiometabolism><cardiovascular disorder><care access><child bearing><childbearing><cohort><complications during pregnancy><data registry><depression symptom><depressive><depressive symptoms><develop therapy><developmental><diet and exercise><disadvantaged group><disadvantaged individual><disadvantaged people><disadvantaged population><disadvantaged subgroup><disparities across groups><disparities in race><disparity across subgroups><disparity among groups><disparity among subgroups><disparity between groups><disparity between subgroups><disparity due to race><epidemiologic><epidemiological><expectant mother><expectant women><expecting mother><expecting women><experience><faces><facial><fasting glucose><follow up><follow-up><followed up><followup><group disparity><group inequality><group inequity><health service access><health services availability><high risk><histories><hypertensive disease during pregnancy><hypertensive disease in pregnancy><hypertensive disease of pregnancy><hypertensive disorder during pregnancy><hypertensive disorder in pregnancy><hypertensive disorder of pregnancy><incomes><individuals who are pregnant><inequalities among populations><inequalities between populations><inequalities in populations><inequality across populations><inequality among groups><inequality between groups><inequality due to race><inequality in groups><inequities among populations><inequities between populations><inequities in populations><inequity across groups><inequity across populations><inequity between groups><inequity due to race><inequity in groups><infant outcome><intervention development><lactating><lactational><later in life><later life><life course><long-term sequelae><long-term study><longitudinal outcome studies><longitudinal research study><maternal death><maternal morbidity><maternal risk><mid life><mid-life><middle age><middle aged><midlife><multi-ethnic><multiethnic><novel><pathophysiology><pediatric><people who are pregnant><placenta morphology><placental morphology><population inequality><population inequity><post pregnancy><post-partum><post-partum outcome><post-partum weight><post-trauma stress disorder><postpartum outcome><postpartum weight><posttrauma stress disorder><preconception><pregnancy diabetes><pregnancy disorder><pregnancy induced hypertensive disorder><pregnancy related hypertensive disease><pregnancy-related complications><pregnancy-specific hypertensive disorder><pregnant><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal><prevent><preventing><prior to conception><prospective><psychosocial well-being><psychosocial wellbeing><psychosocial wellness><quality of sleep><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial disparity><racial inequality><racial inequity><racial minority><racially unequal><racism><rate of change><reactioncrisis><recruit><service availability><sleep amount><sleep duration><sleep episode><sleep interval><sleep length><sleep period><sleep quality><sleep quantity><sleep time><social health determinants><social role><social support network><socio-economic disparity><socio-economic inequality><socio-economic inequity><socioeconomic disparity><socioeconomic inequality><socioeconomic inequity><stress response><stressreaction><stressor><structural determinants><structural factors><subgroup disparity><theories><therapy development><those who are pregnant><time asleep><time during sleep><time in sleep><time spent asleep><time spent sleeping><traumatic neurosis><treatment access><treatment development><unborn><unequal group><unequal population><women who are pregnant><wt-loss>
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Jasmine Miller-Kleinhenz

UNIVERSITY OF MISSISSIPPI MED CTR, JACKSON, MS

Exploratory lead · 22/100
Recent
Active award
$248,755
FY 2026

Project Title

Investigating Socio-Structural Determinants of Health and the Tumor Epigenome to Understand the Etiology of Racial Disparities in Breast Cancer

Grant Number:

5R00CA267674-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/11/2022

End Date:

1/31/2027

Project Abstract

The overarching goal of this project is to examine how socio-structural determinants of health impact the breast tumor DNA methylome, activation of oncogenic signaling, and ultimately, the disparate development of triple-negative breast cancer (TNBC) in different populations. The etiologic basis of ...

Research Terms

<Address><Affect><Air Pollution><Area><Award><BeadChip><Beta Cadherin-Associated Protein><Beta-1 Catenin><Biological><Body Tissues><Breast Cancer><Breast Cancer Patient><Breast Neoplasms><Breast Tumor Patient><Breast Tumors><CUL-2><Cancers><Caucasian Females><Caucasian Women><Causality><Cell Communication and Signaling><Cell Signaling><Chronic><Communication><DNA><DNA Methylation><DNA Sequence><Data><Deoxyribonucleic Acid><Development><Diagnosis><Disparate><Drug Therapy><Drug resistance><Education><Educational aspects><Environment><Environmental Factor><Environmental Risk Factor><Epidemiology><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Exclusion><Exposure to><Fostering><Gene Expression><Genes><Genetic Diversity><Genetic Variation><Goals><Green space><Health><Health Care><Hematology><Housing><Incidence><Inflammation><Intervention><Intracellular Communication and Signaling><Investigation><Investigators><Knowledge><Leadership><Learning><Life Style><Lifestyle><Link><Location><Malignant Breast Neoplasm><Malignant Neoplasms><Malignant Tumor><Mammary Cancer><Mammary Neoplasms><Measures><Mentors><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Methylation><Molecular><Molecular Epidemiology><Neighborhoods><Neoplasm Metastasis><Nutrition><Oncogenesis><Oncogenic><Oncology><Oncology Cancer><Outcome><PRO2286><Pathology><Pathway interactions><Pharmacological Treatment><Pharmacotherapy><Phase><Phenotype><Physical activity><Play><Policies><Population><Position><Positioning Attribute><Prevalence><Psychosocial Stress><Public Health Schools><Publishing><Reporting><Research><Research Personnel><Researchers><Role><Sampling><Secondary Neoplasm><Secondary Tumor><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Skin><Stress><TNBC><Tissues><Tobacco smoke><Training><Tumor Biology><Tumor Expansion><Tumor Subtype><Tumor Tissue><Universities><Variant><Variation><White Females><White Women><Woman><Work><aggressive breast cancer><bead chip><beta cat><beta catenin><biobank><biologic><biological signal transduction><biorepository><black female><black women><cancer epidemiology><cancer metastasis><cancer registry><cancer sub-types><cancer subtypes><causation><developmental><diagnosis among females><diagnosis among women><diagnosis in females><diagnosis in women><diagnosis within females><diagnosis within women><didactic curriculum><didactic education><differences in health><disease causation><disparities in race><disparity due to race><drug intervention><drug resistant><drug treatment><environmental risk><epidemiologic><epidemiological><epigenetically><epigenome><experience><female diagnosis><greenspace><health determinants><health difference><individuals with breast cancer><inequality due to race><inequity due to race><inhibitor><job environment><malignancy><malignant breast tumor><mammary tumor><methylome><mortality><neoplasm registry><neoplasm/cancer><pathway><patients with breast cancer><person with breast cancer><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><professional atmosphere><professor><programs><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial disparity><racial inequality><racial inequity><racially unequal><resistance to Drug><resistant to Drug><skills><social><social disadvantage><social disparities><social epidemiology><social factors><social health determinants><social inequality><social role><social structural><social structure><socio-structural><sociostructural><structural health determinants><systemic barrier><systemic hurdle><systemic obstacle><triple-negative breast cancer><triple-negative invasive breast carcinoma><tumor><tumor DNA><tumor cell DNA><tumor cell metastasis><tumor-specific DNA><tumorigenesis><women's diagnosis><work atmosphere><work environment><workplace climate><workplace environment><β-catenin>
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Xiangqin He

LOUISIANA STATE UNIV HSC SHREVEPORT, SHREVEPORT, LA

Exploratory lead · 22/100
Recent
Active award
$248,679
FY 2026

Project Title

The uncharacterized nuclear protein HMGXB4 in occlusive vascular diseases

Grant Number:

4R00HL171834-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/18/2026

End Date:

1/31/2029

Project Abstract

PROJECT SUMMARY Vascular smooth muscle cell (VSMC) phenotypic modulation, from contractile to proliferative phenotypes, is central to the etiologies of human occlusive vascular diseases, such as restenosis and atherosclerosis. Identification of the key players that regulate VSMC phenotypic switching...

Research Terms

<ASCVD><Angioplasty><Antigenic Determinants><Aorta><Arterial Fatty Streak><Arterial Injury><Arteries><Assay><Atheroma><Atheromatous><Atheromatous degeneration><Atheromatous plaque><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Attenuated><Automobile Driving><Binding><Binding Determinants><Binding Sites><Bioassay><Biological Assay><Blood Vessels><Cardiac artery><Cardiovascular Diseases><Causality><Cause of Death><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Nucleus><Cells><ChIP Sequencing><ChIP assay><ChIP-seq><ChIPseq><Chromosomes><Closure by Ligation><Combining Site><Complex><Coronary Arteriosclerosis><Coronary Artery Disease><Coronary Artery Disorder><Coronary Atherosclerosis><Coronary artery><Data><Data Set><Development><Disease><Disorder><Dose><Endotoxins><Enhancers><Epitopes><Etiology><Feedback><GWA study><GWAS><Gene Expression><Gene Inactivation><Gene Silencing><Gene Transcription><Gene variant><Genes><Genetic Transcription><Goals><Growth Agents><Growth Factor><Growth Substances><HMG-1 Domain><HMG-1-Box Domain><HMG-Box><HMG-Box Domains><Heart artery><High Mobility Group-Box Domains><Human><Hyperlipemia><Hyperlipidemia><Immunoglobulin Enhancer-Binding Protein><In Vitro><Inflammation><Inflammatory><Injury><Involuntary Muscle><KI mice><KO mice><Knock-in><Knock-in Mouse><Knock-out Mice><Knockout Mice><Leiomyocyte><Lesion><Ligation><Luciferase Immunologic><Luciferases><Mediating><Messenger RNA><Mice><Mice Mammals><Modeling><Modern Man><Molecular Interaction><Murine><Mus><NF-kB><NF-kB Signaling Pathway><NF-kappa B><NF-kappaB><NFKB><NFKB Signaling Pathway><Nuclear><Nuclear Factor kappa B><Nuclear Protein><Nuclear Transcription Factor NF-kB><Nucleus><Null Mouse><PIM1><PIM1 gene><Pathologic><Pathway interactions><Phase><Phenotype><Phosphorylation><Proliferating><Protein Phosphorylation><Proteins><Proteins Growth Factors><Provirus Insertion Site Gene-1><RNA Expression><Reactive Site><Reporter><Research><Risk><Role><Sampling><Saphenous Vein><Serum Response Factor><Single-Nucleus Sequencing><Smooth Muscle><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Stimulus><Testing><Time><Training><Transcription><Transcription Factor NF-kB><Transcription Factor SRF><United States><Vascular Diseases><Vascular Disorder><Vascular Smooth Muscle><Vascular remodeling><Vein graft><allelic variant><atheromatosis><atherosclerosis plaque><atherosclerotic coronary disease><atherosclerotic disease><atherosclerotic lesions><atherosclerotic plaque><atherosclerotic vascular disease><attenuate><attenuates><blood vessel disorder><c-fos Serum Response Factor><cardiovascular disorder><career><causation><cellular differentiation><chromatin immunoprecipitation><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><clinical significance><clinically significant><cofactor><coronary arterial disease><cytokine><developmental><disease causation><driving><epigenome><femoral artery><gene locus><genetic approach><genetic locus><genetic strategy><genetic variant><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic location><genomic locus><genomic variant><global gene expression><global transcription profile><graft failure><human model><in vitro Assay><in vivo><injuries><insight><intraluminal angioplasty><kappa B Enhancer Binding Protein><knock-down><knockdown><knockin><knockin mice><mRNA><model of human><mouse model><multiomics><multiple omics><murine model><myocardin><neointima formation><neointimal thickening><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><nuclear factor kappa beta><overexpress><overexpression><p65><panomics><pathway><pharmacologic><plaques in atherosclerosis><promoter><promotor><restenosis><sNuc-Seq><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single nucleus RNA-sequencing><single nucleus seq><single-cell RNA sequencing><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><systemic inflammation><systemic inflammatory response><transcriptional silencing><transcriptome><vascular><vascular contributions><vascular dysfunction><vascular inflammation><vasculopathy><whole genome association analysis><whole genome association study>
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Matthew Gregory Jones

MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CAMBRIDGE, MA

Exploratory lead · 22/100
Recent
Active award
$248,618
FY 2026

Project Title

Quantitative modeling of extrachromosomal DNA (ecDNA) evolution in tumors

Grant Number:

4R00CA286968-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

1/31/2029

Project Abstract

Project Summary. Cancer is governed by evolutionary principles whereby sequential changes at the genetic and epigenetic level enable proliferation, immune evasion, drug resistance, and metastasis. An outstanding goal in cancer biology is to understand the spatiotemporal processes underpinning this e...

Research Terms

<Acceleration><Address><Advisory Committees><Algorithms><Automobile Driving><Award><Behavior><Bioinformatics><Biological><Biology><CRISPR><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas system><CRISPR/Cas9 screen><Cancer Biology><Cancer Genes><Cancer-Promoting Gene><Cancers><Catalogs><Cell Body><Cells><Chromatin><Chromosomal Amplification><Chromosomal Duplication><Chromosomes><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats><Communities><Computational toolkit><Computer software><Computing Methodologies><DNA amplification><DNA mutation><DNA-Protein Interaction><Data><Data Set><Development><Drug Targeting><Drug resistance><Engineering><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Evolution><Exhibits><Foundations><Future><Gene Expression><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genetic study><Goals><Heterogeneity><History><Immune Evasion><Individual><Learning><M Phase><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Mediating><Mentorship><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Methylation><Mitosis><Mitosis Stage><Modeling><Molecular><Molecular Fingerprinting><Molecular Profiling><Mutation><Neoplasm Metastasis><Oncogenes><Phase><Population><Process><Proliferating><Property><Recording of previous events><Research><Resolution><Science><Secondary Neoplasm><Secondary Tumor><Software><Solid><Task Forces><Techniques><Technology><Time><Training><Transforming Genes><Universities><Work><acquired drug resistance><advisory team><biologic><cancer cell><cancer metastasis><cancer progression><catalog><clustered regularly interspaced short palindromic repeats screen><computational methodology><computational methods><computational toolbox><computational tools><computational toolset><computer based method><computer methods><computerized tools><computing method><developmental><driving><drug resistant><effective therapy><effective treatment><epigenetically><epigenomics><extrachromosomal DNA><fitness><genome mutation><histories><immune evasive><improved><innovate><innovation><innovative><insight><intermolecular interaction><long read seq><long-read sequencing><long-read transcript sequencing><malignancy><molecular profile><molecular signature><multiomics><multiple omics><neoplasm progression><neoplasm/cancer><neoplastic progression><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><panomics><patient stratification><resistance to Drug><resistant to Drug><resolutions><response><segregation><single molecule><spatial and temporal><spatial temporal><spatiotemporal><stem><stratified patient><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tool><training opportunity><training project><treatment strategy><tumor><tumor cell metastasis><tumor progression>
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Michelle Bedenbaugh

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Exploratory lead · 22/100
Recent
Active award
$247,206
FY 2026

Project Title

Melanocortin-3 receptor in feeding and anxiety neural circuits

Grant Number:

5R00DK133560-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/3/2025

End Date:

3/31/2028

Project Abstract

PROJECT SUMMARY (See instructions): Neural circuits modulating feeding, stress and anxiety must communicate with each other to maintain homeostasis. Failure to appropriately respond to certain stressors can promote the development of maladaptive feeding behaviors observed with obesity and metabol...

Research Terms

<21+ years old><3-D Images><3-D image><3D image><3D images><Adult><Adult Human><Anatomic Sites><Anatomic structures><Anatomy><Anorexia><Anxiety><Anxiety Disorders><Area><Automobile Driving><Autoregulation><Bed Nucleus of Stria Terminalis><Behavior><Behavioral><Binge eating disorder><Body Tissues><Brain><Brain Nervous System><Brain Stem><Brainstem><Cell Body><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Cells><Clinical><Communication><Complex><Cues><Development><Differences between sexes><Differs between sexes><Disease><Disorder><Eating><Eating Disorders><Emotional><Encephalon><Experimental Genetics><Exposure to><Failure><Feeding behaviors><Female><Fiber><Food Energy><Food Intake><Health><Heterogeneity><High Fat Diet><Homeostasis><Hypothalamic structure><Hypothalamus><Image Analyses><Image Analysis><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Individual><Ingestive Behavior><Instruction><Intracellular Communication and Signaling><Lactation><Link><MC3 Receptor><Maps><Mediating><Melanocortin 3 Receptor><Mental disorders><Mental health disorders><Metabolic Diseases><Metabolic Disorder><Methods><Mice><Mice Mammals><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuroendocrine><Neuroendocrine System><Neurologic><Neurological><Neurons><Neurosecretory Systems><Nuclear><Nucleus><Obesity><Organism-Level Process><Organismal Process><Output><Overweight><Pathologic><Pathological anxiety><Phase><Phenotype><Photometry><Physiologic Processes><Physiological Homeostasis><Physiological Processes><Population><Position><Positioning Attribute><Predisposition><Prevalence><Process><Psychiatric Disease><Psychiatric Disorder><Psychopathology><Receptor, Melanocortin, Type 3><Regulation><Role><Sex Differences><Sexual differences><Signal Transduction><Signal Transduction Systems><Signaling><Site><Social isolation><Stress><Stria Terminalis Nucleus><Structure><Structure of terminal stria nuclei of preoptic region><Susceptibility><System><Techniques><Testing><Thesaurismosis><Three-Dimensional Image><Time><Tissues><Training><Viral><Viral Genetics><Work><abnormal psychology><adiposity><adulthood><anorexic><anxiety-like behavior><biological signal transduction><corpulence><critical period><developmental><dietary><driving><driving behavior><early life stress><energy balance><experience><experiment><experimental research><experimental study><experiments><feeding><feeding-related behaviors><food Ingestion><food avoidance><food consumption><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><hypothalamic><image evaluation><image interpretation><in vivo><lactating><lactational><large data sets><large datasets><male><mental illness><metabolism disorder><motivated behavior><neural><neural circuit><neural circuitry><neurocircuitry><neuronal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><nutrient intake activity><psychiatric illness><psychological disorder><receptor expression><response><restraint stress><severe anxiety><sex><sex based differences><sex dimorphism><sex-dependent differences><sex-related differences><sex-specific differences><sexual dimorphism><sexually dimorphic><social role><stressor><synaptic circuit><synaptic circuitry><virus genetics><♀><♂>
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Kelly Alexandra Hyland

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Exploratory lead · 22/100
Recent
Active award
$245,490
FY 2026

Project Title

LiveWell: An Adapted Dialectical Behavioral Therapy Skills Training Protocol for Patients Living with Metastatic Lung Cancer

Grant Number:

5R00CA286959-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

3/31/2028

Project Abstract

Patients are living longer with metastatic lung cancer (i.e., metavivors) due to therapeutic advances, but face significant challenges. Most metavivors will ultimately die of cancer and must navigate the duality of living while dying. Unsurprisingly, metavivors endorse high psychological distress (e...

Research Terms

<Active Follow-up><Address><Adherence><After Care><After-Treatment><Aftercare><Anxiety><Behavior><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Model><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Behavioral trial><Breathlessness><Cancer Center><Cancer Intervention><Cancer Patient><Cancers><Caring><Chest><Chronic Disease><Chronic Illness><Clinic><Conditioning Therapy><Consultations><Data><Diagnostic><Disease><Disorder><Disseminated Malignant Neoplasm><Distress><Dose><Dyspnea><Education for Intervention><Educational Intervention><Educational process of instructing><Effectiveness><Emotional><Emotional Depression><Evidence based treatment><Face><Fatigue><Feasibility Studies><Feedback><Funding><Future><Health><Instruction Intervention><Intervention><Interview><Investigators><Ixodida><Lack of Energy><Leadership><Learning><Life><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Mediation><Mental Depression><Mentors><Metastatic Cancer><Metastatic Malignant Neoplasm><Methods><Monitor><Negotiating><Negotiation><Oncologist><Outcome><Pain><Painful><Participant><Patients><Pattern><Phase><Procedures><Process><Protocol><Protocols documentation><Provider><Psychotherapy><Pulmonary Cancer><Pulmonary malignant Neoplasm><QOL><QOL improvement><Quality of life><Randomized><Randomized, Controlled Trials><Research><Research Personnel><Researchers><Role><Scientist><Standardization><Survival Rate><Symptom Burden><Symptoms><Teaching><Testing><Therapeutic><Thinking><Thorace><Thoracic><Thoracic Oncology><Thorax><Ticks><Time><Training><Training Intervention><Uncertainty><Work><active followup><arm><behavior change><behavior intervention><behavioral clinical trial><behavioral intervention><care as usual><chronic disorder><chronic symptom><clinical significance><clinically significant><compare treatment><consultation><coping><depression><depression symptom><depressive><depressive symptoms><design><designing><develop therapy><distress tolerance><doubt><efficacy trial><emotion regulation><emotional experience><emotional regulation><evidence base><experience><faces><facial><follow up><follow-up><followed up><followup><implementation framework><implementation research framework><implementation science><implementation science framework><improved><improved outcome><improvements in QOL><improvements in quality of life><instructional intervention><interest><intervention development><lung cancer><malignancy><manage symptom><member><mindfulness><model development><model developments><neoplasm/cancer><novel><persistent symptom><pilot test><pilot trial><post treatment><primary outcome><psychological distress><psychological symptom><psychosocial><quality of life improvement><randomisation><randomization><randomized control trial><randomly assigned><response><satisfaction><secondary outcome><skills><skills training><social role><sustainability framework><symptom management><telehealth><therapy development><thoughts><treatment as usual><treatment comparison><treatment development><trial design><usual care><videoconference><videoconferences>
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Daysha Ferrer Torres

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 22/100
Recent
Active award
$241,593
FY 2026

Project Title

Utilizing a human stem cell model of the esophagus to understand racial disparities during injury repair

Grant Number:

5R00DK133804-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/22/2022

End Date:

12/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT African Americans (AA) and European Americans (EA) have a similar prevalence of gastro-esophageal reflux disease (GERD). Nonetheless, when compared to EA, AA show a lower incidence of esophagus damage, metaplasia, and esophageal adenocarcinoma. Population genetics and molecu...

Research Terms

<2-dimensional><3-D><3-Dimensional><3D><AI system><Acid Reflux><Acids><Active Oxygen><Address><Adenocarcinoma of the Esophagus><African American><African American group><African American individual><African American people><African American population><African Americans><Afro American><Afroamerican><American><Area><Artificial Intelligence><Assay><Autoregulation><Barrett Esophagus><Barrett Syndrome><Barrett Ulcer><Bile><Bile Acids><Bile Juice><Bile fluid><Bioassay><Biologic Models><Biological Assay><Biological Models><Body Tissues><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Death><Cell Line><Cell Protection><CellLine><Cells><Cellular injury><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Columnar Epithelial-Lined Lower Esophagus><Columnar-Lined Esophagus><Committee Members><Computer Reasoning><Coupled><Cytoprotection><DNA Damage><DNA Injury><Data><Disease><Disorder><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Drug Screening><Drugs><Enzyme Gene><Enzymes><Epithelium><Esophageal Adenocarcinoma><Esophageal Diseases><Esophageal Disorder><Esophageal Reflux><Esophageal Tissue><Esophageal injury><Esophagitis><Esophagus><European><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Fellowship><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><GERD><GSTT2><GSTT2 gene><Gastric Acid><Gastric Hydrochloric Acid><Gastro-oesophageal Reflux><Gastroesophageal Reflux><Gastroesophageal reflux disease><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Genes><Genetic><Glutathione S-Transferase, Theta-2><Goals><Health><Homeostasis><Human><Image><Image Analyses><Image Analysis><In Vitro><Incidence><Individual><Injury><Injury to Esophagus><Investigation><Lead><Libraries><Machine Intelligence><Machine Learning><Mediating><Mediation><Medication><Mentors><Metabolic Drug Detoxications><Metabolism of Toxic Agents><Metaplasia><Metaplastic Change><Methods><Michigan><Model System><Modeling><Modern Man><Modification><Molecular><Molecular Fingerprinting><Molecular Profiling><Molecular Target><Natural Products><Negotiating><Negotiation><Organoids><Oxygen Radicals><Pathway interactions><Patients><Pb element><Pharmaceutical Preparations><Phase><Phenotype><Physiological Homeostasis><Play><Population Genetics><Population Heterogeneity><Postdoc><Postdoctoral Fellow><Predisposition><Prevalence><Pro-Oxidants><Progenitor Cells><Proliferating><Reactive Oxygen Species><Reporting><Research><Research Associate><Research Resources><Resources><Role><Stomach><Strains Cell Lines><Susceptibility><Techniques><Testing><Tissue Sample><Tissues><Training><Transcript Expression Analyses><Transcript Expression Analysis><Universities><Work><analyze gene expression><biobank><biological adaptation to stress><biorepository><cell damage><cell injury><cellular damage><clinical immersion><cohort><critical injury><cultured cell line><cytoprotective><damage to cells><data acquisition><data acquisitions><design><designing><detoxification><devastating injury><diseases of esophagus><disparities in race><disparity due to race><diverse populations><drug discovery><drug/agent><esophageal intestinal metaplasia><esophageal progenitors><esophageal stem cell><esophagus disorder><experiment><experimental research><experimental study><experiments><fitness><gain of function><gastric><gene expression analysis><gene expression assay><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><genome editing><genomic editing><heavy metal Pb><heavy metal lead><heterogeneous population><human progenitor><human stem cells><human tissue><image evaluation><image interpretation><image-based method><imaging><imaging method><imaging modality><in vivo><inequality due to race><inequity due to race><injuries><injury and repair><injury response><injury to cells><loss of function><machine based learning><molecular profile><molecular signature><naturally occurring product><necrocytosis><pathway><population diversity><post-doc><post-doctoral><post-doctoral trainee><prevent><preventing><progenitor cell model><progenitor model><programs><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial disparity><racial diversity><racial inequality><racial inequity><racially diverse><racially unequal><reactioncrisis><repair><repaired><research associates><research immersion><response><response to injury><scRNA sequencing><scRNA-seq><screening><screenings><severe injury><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><stem cells><stress response><stressreaction><three dimensional><tool><transcriptional profiling><transcriptome profiling><transcriptomic profiling><transcriptomics><two-dimensional><vector>
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ANUBHA AGARWAL

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 22/100
Recent
Active award
$124,758
FY 2026

Project Title

Heart Failure Polypill in India: A Late-Stage Implementation Strategy

Grant Number:

5R00HL157687-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/9/2024

End Date:

11/30/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Heart failure (HF) is a leading global public health problem. The burden of HF is increasing in low- and middle- income countries and clinical outcomes remain poor. Guideline-directed medical therapy (a combination of distinct medications from disparate drug classes) improve...

Research Terms

<21+ years old><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Adherence><Adopted><Adrenergic beta-Antagonists><Adrenergic beta-Blockers><Adult><Adult Human><Adverse Experience><Adverse event><Age><Aldosterone Receptor><Angiotensin Receptor><Area><Assess implementation><Australia><Cardiomyopathies><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Caring><Chronic><Chronic Disease><Chronic Illness><Cities><Clinical><Clinical Trials><Clinical Trials Design><Collaborations><Consensus><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Country><Data Collection><Developing Countries><Developing Nations><Development><Development and Research><Disease><Disease Marker><Disorder><Disparate><Drug Therapy><Drugs><Economic Income><Economical Income><Eligibility><Eligibility Determination><Ensure><Evaluation><Focus Groups><Funding><Future><Global Change><Goals><Guidelines><HIV><Health Care Providers><Health Personnel><Heart><Heart Vascular><Heart failure><Hospital Admission><Hospitalization><Hospitals><Human Immunodeficiency Viruses><Hybrids><Hypertension><Implementation assessment><Income><India><Individual><Interruption><Intervention><Investments><Kansas><LAV-HTLV-III><LMIC><LVEF><Left Ventricular Ejection Fraction><Less-Developed Countries><Less-Developed Nations><Lymphadenopathy-Associated Virus><Measures><Medical><Medication><Mentorship><Methodology><Methods><Mineralocorticoid Receptor><Morbidity><Myocardial Diseases><Myocardial Disorder><Myocardiopathies><NHLBI><NIH><National Heart, Lung, and Blood Institute><National Institutes of Health><Natriuretic Peptide Hormones><Natriuretic Peptides><New York><Outcome><Participant><Patient Care><Patient Care Delivery><Patients><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Phase><Position><Positioning Attribute><Prevalence><Process><Protocol Screening><Public Health><Questionnaires><R & D><R&D><RE-AIM><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Registries><Reporting><Research><Research Methodology><Research Methods><Risk Factors><Safety><Science><Series><Serious Adverse Event><Severe Adverse Event><Severity of illness><Strategic vision><Target Populations><Third-World Countries><Third-World Nations><Time><Titrations><Training><Training Activity><Translating><Treatment Failure><Under-Developed Countries><Under-Developed Nations><United States><United States National Institutes of Health><Universities><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Virus-HIV><Withdrawal><adulthood><ages><antagonism><antagonist><barriers to implementation><beta blocker><beta-Adrenergic Blocking Agents><beta-Adrenergic Receptor Blockaders><burden of disease><burden of illness><cardiac failure><cardiovascular disorder><care as usual><care for patients><care of patients><career><caring for patients><chronic disorder><circulatory system><design><designing><developing country><developing nation><developmental><disease burden><disease control><disease severity><disorder control><drug adherence><drug compliance><drug intervention><drug treatment><drug/agent><evaluate implementation><evaluation of implementation><evidence base><global health><health care personnel><health care worker><health provider><health related quality of life><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><heart failure and reduced ejection fraction><heart failure with reduced ejection fraction><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><implementation barriers><implementation challenges><implementation evaluation><implementation outcomes><implementation science><implementation strategy><improved><incomes><innovate><innovation><innovative><low and middle-income countries><medical care providers><medical personnel><medication adherence><medication compliance><meeting><meetings><mortality><multidisciplinary><myocardium disease><myocardium disorder><new approaches><novel><novel approaches><novel strategies><novel strategy><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><primary outcome><process evaluation><randomized, clinical trials><reach, efficacy, adoption, implementation, and maintenance><research and development><research and methods><secondary outcome><serious adverse experience><serious adverse reaction><sex><socio-economic><socio-economically><socioeconomically><socioeconomics><strategies for implementation><success><therapy failure><training module><treatment as usual><treatment provider><trial design><usual care>
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Katherine Miles Johnston McMurray

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Acid sensing associated mechanisms in AUD and comorbid panic

Grant Number:

5R00AA029168-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/20/2022

End Date:

1/31/2027

Project Abstract

Project Summary/Abstract Alcohol’s effects on the body are complex, altering behaviors, emotions and physiology. These effects all contribute to the cycle of alcohol use and abuse that leads to alcohol use disorders (AUDs). They also contribute to the development of comorbid psychiatric disorders, l...

Research Terms

<Absolute ethanol><Abstinence><Acid-Base Imbalance><Acidosis><Acids><Acute><Alcohol Drinking><Alcohol abuse><Alcohol consumption><Alcohol dependence><Alcohol withdrawal syndrome><Anxiety><Attenuated><Autoregulation><Behavior><Behavioral><Blood - brain barrier anatomy><Blood Pressure><Blood-Brain Barrier><Brain><Brain Nervous System><CO2><Carbon Dioxide><Carbonic Anhydride><Cardiac Chronotropism><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular Physiology><Cardiovascular system><Cell Communication and Signaling><Cell Death><Cell Signaling><Collection><Complex><Darkness><Data><Dependence><Development><Disease><Disorder><Dysfunction><ETOH><Emotional><Emotions><Encephalon><EtOH abuse><EtOH drinking><EtOH use><Ethanol><Ethyl Alcohol><Fear><Foundations><Fright><Functional disorder><Genes><Genetic><Goals><Grain Alcohol><Heart Rate><Heart Vascular><Hemato-Encephalic Barrier><Homeostasis><Hyperventilation><Individual><Inhalation><Inhaling><Intracellular Communication and Signaling><Lesion><Mediating><Mental disorders><Mental health disorders><Methods><Methylcarbinol><Mice><Mice Mammals><Modeling><Molecular><Murine><Mus><Neuroimmune><Neuroimmune Mechanisms><Neuroimmune Processes><Neuroimmunomodulation><Outcome><Panic><Panic Attack><Panic Disorder><Pathology><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phase><Physiologic><Physiological><Physiological Homeostasis><Physiology><Physiopathology><Plethysmography><Position><Positioning Attribute><Predisposition><Psychiatric Disease><Psychiatric Disorder><Publishing><Research><Respiration><Rodent><Rodentia><Rodents Mammals><Role><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Stress><Subfornical Organ><Susceptibility><T cell regulation><T-Cells><T-Lymphocyte><Telemetries><Telemetry><Testing><Time><Training><Treatment outcome><Upregulation><Viral><Withdrawal><alcohol addiction><alcohol co-abuse><alcohol co-morbidity><alcohol comorbidity><alcohol dependency><alcohol dependent><alcohol effect><alcohol ingestion><alcohol intake><alcohol problem><alcohol product use><alcohol use><alcohol use disorder><alcohol use prevention><alcohol withdrawal><alcoholic beverage consumption><alcoholic drink intake><attenuate><attenuates><awake><base><bases><binge alcohol consumption><binge drinking><biological signal transduction><bloodbrain barrier><cardiovascular effects><cardiovascular function><career><chronic EtOH drinking><chronic alcohol consumption><chronic alcohol drinking><chronic alcohol ingestion><chronic alcohol use><chronic ethanol consumption><chronic ethanol drinking><chronic ethanol ingestion><circulatory system><co-morbid><co-morbidity><comorbidity><deter alcohol use><developmental><drinking><episodic drinking><ethanol abuse><ethanol consumption><ethanol drinking><ethanol effect><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><ethanol use disorder><ethanol withdrawal><hazardous alcohol use><heart rate variability><improved><knock-down><knockdown><mental illness><mouse model><murine model><necrocytosis><neural circuit><neural circuitry><neural inflammation><neurocircuitry><neuroinflammation><neuroinflammatory><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><panic anxiety syndrome><pathophysiology><patient oriented outcomes><prevent alcohol use><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><promoter><promotor><psychiatric co-morbidity><psychiatric comorbidity><psychiatric illness><psychological disorder><resilience><resilient><respiratory><respiratory mechanism><response><sensor><social role><synaptic circuit><synaptic circuitry><telemetric><thymus derived lymphocyte><withdrawal from alcohol>
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Jinshil Hyun

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Neighborhood characteristics, GPS-based activity space, and cognitive health

Grant Number:

5R00AG080126-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2028

Project Abstract

Project Summary/Abstract The Pathway to Independence Award will help launch Dr. Jinshil Hyun’s independent research career focused on environmental/behavioral factors that modify trajectories of cognitive aging and Alzheimer’s disease and associated dementia (ADRD). Her proposed aims use geospa...

Research Terms

<AD and related dementia><AD dementia><AD related dementia><ADRD><APOE e4><APOE-ε4><APOEε4><Active Follow-up><Address><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Amentia><Amyloid><Amyloid Substance><Area><Award><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biological Markers><Biometrics><Biometry><Biostatistics><Blood Vessels><Cell Phone><Cellular Phone><Cellular Telephone><Characteristics><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Conditioning Therapy><Data><Data Analyses><Data Analysis><Data Collection><Data Set><Dedications><Dementia><Development><Disparities><Disparity><Disturbance in cognition><Ecological momentary assessment><Environment><Exposure to><Foundations><Geographic Information Systems><Health><Impaired cognition><Individual><Intervention><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Magnetic Resonance Imaging><Measures><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medicine><Mentors><Methods><Mobile Phones><NMR Imaging><NMR Tomography><Neighborhoods><Nerve Degeneration><Neuro-epidemiology><Neuroepidemiology><Neuron Degeneration><Neuropsychologic Tests><Neuropsychological Tests><Neuropsychologies><Neuropsychology><Nuclear Magnetic Resonance Imaging><Outcome><Outcome Measure><Participant><Pathology><Pathway interactions><Pattern><Perception><Persons><Phase><Policies><Population><Primary Senile Degenerative Dementia><Process><Race><Races><Research><Research Resources><Resources><Risk><Risk Factors><Scientist><Subgroup><Suggestion><Training><Urban Health><Variant><Variation><Vulnerable Populations><White Matter Hyperintensity><Zeugmatography><active followup><apo E-4><apo E4><apo epsilon4><apoE epsilon 4><apoE-4><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-4><apolipoprotein E4><behavior intervention><behavioral intervention><bio-markers><biologic marker><biological sex><biomarker><brain health><career><cognitive assessment><cognitive dysfunction><cognitive function><cognitive loss><cognitive performance><cognitive testing><college><collegiate><data interpretation><developmental><disparity in health><experience><follow up><follow-up><followed up><followup><geospatial information system><health disparity><iPhone><late in life><late life><measurable outcome><microtubule bound tau><microtubule-bound tau><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><multidisciplinary><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal degeneration><neuropsychologic><outcome measurement><pathway><primary degenerative dementia><protective factors><racial><racial background><racial origin><senile dementia of the Alzheimer type><smart phone><smartphone><social><spatial and temporal><spatial temporal><spatiotemporal><tau><tau Proteins><tau factor><vascular><vulnerable group><vulnerable individual><vulnerable people><τ Proteins>
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Joshua Daniel Meisel

BRANDEIS UNIVERSITY, WALTHAM, MA

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Identification of genetic and environmental suppressors of mitochondrial dysfunction

Grant Number:

5R00GM140217-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2021

End Date:

12/31/2027

Project Abstract

Project Summary Mitochondrial diseases, or inherited disorders of oxidative phosphorylation, can be caused by mutations in at least 290 genes and affect approximately 1 in 5,000 live births. In addition to this collection of severe and individually rare disorders, mitochondrial dysfunction may under...

Research Terms

<AD dementia><Acyl Carrier Protein><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Anabolism><Animals><Assay><Atmosphere><Binding><Bioassay><Biochemistry><Bioenergetics><Biogenesis><Biological Assay><Biological Chemistry><Biology><Breathing><Bypass><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><Cell Body><Cells><Cellular biology><Collection><Compensation><Complex><Complex I Dehydrogenase><DNA Molecular Biology><DNA mutation><DNA seq><DNA sequencing><DNAseq><Disease><Disorder><Dominant Genes><Dysfunction><EC 2.1.1><Electron Transport Complex I><Electrophoresis><Electrophoretic Fractionation><Environment><Fe element><Ferredoxin><Freidreich's Ataxia><Friedreich Ataxia><Friedreich Disease><Friedreich Spinocerebellar Ataxia><Friedreich's Familial Ataxia><Friedreich's Hereditary Ataxia><Friedreich's Hereditary Spinal Ataxia><Friedreich's tabes><Functional disorder><Gene Expression><Gene Transcription><Genes><Genetic><Genetic Change><Genetic Models><Genetic Screening><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Goals><Health><Hereditary Disease><Hereditary Spinal Sclerosis><Hyperoxia><Hypoxia><Hypoxic><In Vitro><Inborn Genetic Diseases><Individual><Infant Mortality><Infant Mortality Total><Inherited disorder><Inner mitochondrial membrane><Intermediary Metabolism><Iron><Learning><Leigh Disease><Leigh Syndrome><Live Birth><Measurement><Mentors><Metabolic><Metabolic Processes><Metabolism><Metallopeptidases><Metalloproteases><Metalloproteinases><Methylation><Methyltransferase><Mice><Mice Mammals><Microscopy><Mitochondria><Mitochondrial Diseases><Mitochondrial Disorders><Molecular><Molecular Biology><Molecular Interaction><Murine><Mus><Mutation><NADH><NADH DH I><NADH Dehydrogenase Complex 1><NADH Dehydrogenase I><NADH Q1 Oxidoreductase><NADH dehydrogenase (ubiquinone)><NADH-CoQ Reductase><NADH-Coenzyme Q Reductase><NADH-Ubiquinone Oxidoreductase><NADH-Ubiquinone Reductase><Nerve Degeneration><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Neuron Degeneration><Nuclear><Nuclear RNA><O element><O2 element><Organism><Origin of Life><Orphan Disease><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxygen><Oxygen Consumption><Oxygen Deficiency><Paper><Paralysis Agitans><Parkinson><Parkinson Disease><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Phase><Physiology><Physiopathology><Post-Transcriptional RNA Modification><Post-Transcriptional RNA Processing><Primary Parkinsonism><Primary Senile Degenerative Dementia><Proteins><Proteome><RNA Expression><RNA Seq><RNA Stability><RNA methylation><RNA sequencing><RNAseq><Rare Diseases><Rare Disorder><Research><Respiratory Aspiration><Respiratory Complex I><Respiratory Inspiration><Rotenone-Sensitive Mitochondrial NADH-Ubiquinone Oxidoreductase><S element><Subacute Necrotizing Encephalomyelitis><Subacute Necrotizing Encephalomyelopathy><Subacute Necrotizing Encephalopathy><Sulfur><Suppressor Mutations><System><Techniques><Therapeutic><Tracer><Training><Transcription><Translating><Ubiquinone Reductase><Work><aging associated disease><aging associated disorders><aging related disease><aging related disorders><biosynthesis><cell biology><complex 1 dehydrogenase><cysteine desulfurase><death among infants><death in first year of life><death in infancy><death in infants><disease associated with aging><disease model><disease of aging><disorder model><disorder of aging><disorders associated with aging><disorders related to aging><effective therapy><effective treatment><experiment><experimental research><experimental study><experiments><family ataxia><frataxin><gene synthesis><genetic analysis><genome mutation><hereditary disorder><heritable disorder><hyperoxygenation><improved><in vivo><inborn error><infant death><infant demise><infantile death><inherited diseases><inherited genetic disease><inherited genetic disorder><insight><inspiration><living system><methylase><mitochondrial><mitochondrial dysfunction><mortality in infants><mouse model><murine model><mutant><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neurological disease><neuronal degeneration><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><orphan disorder><pathophysiology><patient oriented outcomes><post-doctoral training><prevent><preventing><primary degenerative dementia><rare genetic disease><rare genetic disorder><senile dementia of the Alzheimer type><sensor><skills><stable isotope><transcriptome sequencing><transcriptomic sequencing><transmethylase><type 1 dehydrogenase>
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Yilun Sun

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Investigating the role of neddylation in the repair of topoisomerase I inhibitor-induced replication damage in colorectal cancer

Grant Number:

5R00CA273171-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2027

Project Abstract

PROJECT SUMMARY Colorectal cancer (CRC) is one of the most lethal cancers. The topoisomerase I (TOP1) inhibitor irinotecan is a major component of the current chemotherapeutic regimens for treatment of CRC. TOP1 is an enzyme that resolves DNA topological issues by transient DNA breakage. TOP1-DNA c...

Research Terms

<20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><5-FU><5-Fluracil><5FU><APF-1><ATP-Dependent Proteolysis Factor 1><Affect><Anti-Cancer Agents><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Antioncogene Protein p53><Award><Binding><Campto><Cancer Drug><Cancers><Cell Body><Cell Death><Cell Death Induction><Cells><Cellular Tumor Antigen P53><Cessation of life><ChIP Sequencing><ChIP-seq><ChIPseq><Chemotherapy Protocol><Chemotherapy Regimen><Chemotherapy-Oncologic Procedure><Chromatin><Clinical><Clinical Trials><Colorectal Cancer><Combination Chemotherapy Regimen><Complex><Cytotoxic agent><Cytotoxic drug><DNA><DNA Damage><DNA Damage Repair><DNA Double Strand Break><DNA Injury><DNA Nicking-Closing Protein><DNA Relaxing Enzyme><DNA Relaxing Protein><DNA Repair><DNA Replication><DNA Synthesis><DNA Topoisomerase I><DNA Type 1 Topoisomerase><DNA Untwisting Enzyme><DNA Untwisting Protein><DNA biosynthesis><DNA-protein crosslink><Death><Deoxyribonucleic Acid><Disease><Disorder><Double Strand Break Repair><E3 Ligase><E3 Ubiquitin Ligase><Enzyme Antagonist><Enzyme Gene><Enzyme Inhibitor><Enzyme Inhibitor Agent><Enzyme Inhibitor Drugs><Enzymes><Exposure to><Family><Fluoro Uracil><Fluorouracil><Fluoruracil><Fluouracil><Gene Expression><Generations><Goals><Grant><HMG-20><Heterograft><Heterologous Transplantation><High Mobility Protein 20><High Throughput Assay><Histone H4><Histones><Intermediary Metabolism><Investigation><Investigators><Ligase><Ligase Gene><Liquid Chromatography><Lytotoxicity><Macropain><Macroxyproteinase><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Maps><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Mentors><Metabolic Processes><Metabolism><Mice><Mice Mammals><Modification><Molecular Interaction><Multicatalytic Proteinase><Murine><Mus><NCATS><National Center for Advancing Translational Sciences><Neoplastic Disease Chemotherapeutic Agents><Oncoprotein p53><Organoids><P53><Pathway interactions><Patient Care><Patient Care Delivery><Patients><Phase><Phosphoprotein P53><Phosphoprotein pp53><Population><Pre-Clinical Model><Preclinical Models><Prosome><Proteasome><Proteasome Endopeptidase Complex><Protein TP53><Proteins><Proteosome><Public Health><Quimioterapia><RBX1><RBX1 gene><RING-Box 1><RNA Seq><RNA sequencing><RNAseq><ROC1><Rationalization><Receptor Protein><Regulator of Cullins 1><Repair Complex><Research><Research Personnel><Researchers><Resistance><Role><Safety><Site><Synthetases><System><TP53><TP53 gene><TRP53><Testing><Therapeutic><Topoisomerase><Topoisomerase I><Topoisomerase-I Inhibitor><Training><Treatment Protocols><Treatment Regimen><Treatment Schedule><Tumor Protein p53><Tumor Protein p53 Gene><Tumor-Specific Treatment Agents><Type I DNA Topoisomerases><Ubiquitin><Ubiquitin Ligase Component Gene><Ubiquitin Ligase Gene><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Unscheduled DNA Synthesis><Work><Xenograft><Xenograft procedure><Xenotransplantation><anti-cancer drug><camptosar><cancer cell><cancer chemotherapy><care for patients><care of patients><caring for patients><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><clinical development><clinical efficacy><colon cancer cell line><colon cancer patients><colorectal cancer cell line><colorectal cancer patients><colorectal cancer therapy><colorectal cancer treatment><cytotoxicity><determine efficacy><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experiment><experimental research><experimental study><experiments><genome scale><genome-wide><genomewide><high throughput screening><homologous recombination><improved><inhibitor><irinotecan><malignancy><member><multicatalytic endopeptidase complex><mutant><necrocytosis><neoplasm/cancer><nicking closing enzyme><p53 Antigen><p53 Genes><p53 Tumor Suppressor><pathway><protein p53><receptor><recruit><relaxing enzyme><repair><repaired><resistant><response><social role><swivelase><synergism><tandem mass spectrometry><therapeutic outcome><therapy outcome><transcriptome sequencing><transcriptomic sequencing><ubiquitin ligase><ubiquitin-protein ligase><untwisting enzyme><xeno-transplant><xeno-transplantation>
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Glennis Amelia Logsdon

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Human centromere variation and function

Grant Number:

5R00GM147352-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2022

End Date:

12/31/2026

Project Abstract

The equal segregation of chromosomes during cell division ensures the accurate inheritance of genetic information. Aberrant chromosome segregation can cause an imbalance in chromosome number, or aneuploidy, which can result in spontaneous abortion and birth defects and is a major cause of cancer. Th...

Research Terms

<30 nm Chromatin Fiber><30 nm Fiber><Aberrant Chromosome><Address><Advisory Committees><Affect><Aneuploid><Aneuploidy><Architecture><Assay><Bioassay><Biologic Sciences><Biological Assay><Biological Function><Biological Process><Biological Sciences><Biology><Bioscience><Birth Defects><Cancer Cause><Cancer Etiology><Cancer Induction><Cancers><Cell Body><Cell division><Cells><Center for Cancer Research><Centromere><ChIP assay><Chromatin><Chromatin Fiber><Chromosomal Aberrations><Chromosomal Abnormalities><Chromosomal Alterations><Chromosome Aberrations><Chromosome Alterations><Chromosome Anomalies><Chromosome Segregation><Chromosome abnormality><Chromosomes><Collaborations><Computing Methodologies><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Malformation><Cytogenetic Aberrations><Cytogenetic Abnormalities><DNA Methylation><DNA mutation><Data><Defect><Disease><Disorder><Engineering / Architecture><Ensure><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Event><Exclusion><Foundations><Functional RNA><Gene Transcription><Genetic><Genetic Change><Genetic Diversity><Genetic Transcription><Genetic Variation><Genetic defect><Genetic mutation><Genomics><Goals><Haplotypes><Health><Human><Hybrid capture><Hybridization capture><Individual><Isoforms><Kinetochores><Knowledge><Life><Life Sciences><Location><Malignant Neoplasms><Malignant Tumor><Maps><Mentors><Methods><Micro-tubule><Microtubules><Miscarriage><Modeling><Modern Man><Mutation><NCI Center for Cancer Research><Nature><Noncoding RNA><Nontranslated RNA><Phase><Population><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Process><Protein Isoforms><RNA Expression><Research><Research Associate><Research Resources><Research Training><Resources><Rest><Role><Scientist><Spontaneous abortion><Structure><Tandem Repeat Sequences><Tandem Repeats><Task Forces><Technology><Testing><Training><Transcript><Transcription><Universities><Untranslated RNA><Variant><Variation><Washington><Work><advisory team><carcinogenesis><career development><chromatin immunoprecipitation><chromosomal defect><chromosome defect><chromosome division><computational methodology><computational methods><computer based method><computer methods><computing method><contig><epigenetic variation><epigenetically><genetic information><genome mutation><human model><hybridization-based capture><innovate><innovation><innovative><long read seq><long-read sequencing><long-read transcript sequencing><malignancy><model of human><multiomics><multiple omics><nano pore><nanopore><neoplasm/cancer><noncoding><novel><panomics><post-doc><post-doctoral><post-doctoral trainee><programs><research associates><segregation><skills><social role><tool>
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Kavita Rangan

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

The functional and adaptive roles of RNA recoding

Grant Number:

5R00GM151485-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2023

End Date:

11/30/2027

Project Abstract

PROJECT SUMMARY Organisms use a variety of molecular mechanisms to adapt to their environments. RNA editing occurs widely across organisms and generates non-synonymous codon changes in mRNAs, thereby altering the amino acid sequence of proteins. In cephalopods and fungi, this ‘recoding’ generates i...

Research Terms

<Acclimatization><Affect><Amino Acid Substitution><Aspergillus><Aspergillus nidulans><Assay><Bioassay><Bioinformatics><Biological Assay><Biology><Body Tissues><CURL><Carrier Proteins><Cell Function><Cell Physiology><Cell Process><Cellular Function><Cellular Physiology><Cellular Process><Cephalopod><Cephalopoda><Code><Coding System><Codon><Codon Nucleotides><Compartment of the Uncoupling Receptors and Ligands><Complex><Cues><DNA><DNA Damage Repair><DNA Polymerase II><DNA Polymerase epsilon><DNA Polymerases><DNA Repair><DNA Repair Gene><DNA Replication><DNA Synthesis><DNA biosynthesis><DNA mutation><DNA repair protein><DNA-Dependent DNA Polymerase II><DNA-Dependent DNA Polymerases><DNA-Directed DNA Polymerase><Data><Deoxyribonucleic Acid><Development><Development Plans><Dynein><Dynein ATPase><Dynein Adenosine Triphosphatase><Dynein Adenosinetriphosphatase><Early Endosome><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exposure to><Filamentous Fungi><Fungal RNA><GeneHomolog><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Genomics><Homolog><Homologous Gene><Homologue><Human><In Vitro><Intracellular Transport><Kinesin><Label><Maps><Mentors><Messenger RNA><Micro-tubule><Microscope><Microtubules><Mining><Modern Man><Molds><Molecular><Motility><Motor><Mutagenesis><Mutagenesis Molecular Biology><Mutation><Neurospora><Neurospora crassa><Non-Polyadenylated RNA><Oceans><Organism><Phase><Phenotype><Physiologic><Physiological><Pol II><Polymerase><Primer Extension><Property><Proteins><Publishing><RNA><RNA Editing><RNA Gene Products><RNA Seq><RNA sequencing><RNA, Messenger, Editing><RNAseq><Recombinants><Regulation><Reporter><Research><Ribonucleic Acid><Role><Sea Water><Seawater><Secretory Granules><Secretory Vesicles><Site><Squid><Subcellular Process><Temperature><Testing><Tissues><Training><Transport Protein Gene><Transport Proteins><Transporter Protein><Unscheduled DNA Synthesis><Variant><Variation><Work><Yeasts><career><career development><cell type><conference><convention><developmental><epigenetic regulation><epigenetically><experiment><experimental research><experimental study><experiments><fungus><genetic information><genome mutation><in vivo><interest><living system><mRNA><mutant><mutation assay><novel><peptide aminoacid sequence><peptide sequence><programs><protein aminoacid sequence><protein complex><protein function><response><screening><screenings><single molecule><social role><success><summit><symposia><symposium><trafficking><transcriptome sequencing><transcriptomic sequencing>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ahmad A Cluntun

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Impact and regulation of lactate metabolism in the heart

Grant Number:

5R00HL168312-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2027

Project Abstract

Project Summary/Abstract The heart has a distinct metabolism that supports the continuous pumping of blood. This includes maintaining the pyruvate-lactate axis. This metabolic axis describes the interrelation between three critical metabolic nodes: central carbon metabolism in the cytoplasm, oxidati...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><Artificial Heart Ventricle><Artificial Ventricles><Asymmetric Septal Hypertrophy><Autoregulation><Biochemistry><Bioenergetics><Biological Chemistry><Biology><Carbon><Cardiac><Cardiac Failure Congestive><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac Output><Cardiac Transplantation><Cardiac health><Cardiac-Assist Pumps><Cardiocyte><Cardiomyopathies><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Metabolic Process><Chemicals><Citric Acid Cycle><Clinical Research><Clinical Study><CoA><Coenzyme A><Complex><Congestive Heart Failure><Consumption><Coupled><Cultured Cells><Cytoplasm><D-Glucose><DNA mutation><Data><Development><Dextrose><Disease><Disorder><Drugs><Environment><Environmental Factor><Environmental Risk Factor><Enzyme Gene><Enzymes><Equilibrium><Generations><Genes><Genetic Change><Genetic Models><Genetic defect><Genetic mutation><Glucose><Glycolysis><Health><Heart><Heart Decompensation><Heart Grafting><Heart Hypertrophy><Heart Muscle Cells><Heart Transplantation><Heart failure><Heart health><Heart myocyte><Heart-Assist Devices><Heart-Assist Pumps><Hereditary><Hereditary ventricular hypertrophy><Histones><Homeostasis><Human><Hypertrophic Cardiomyopathy><Hypertrophic Obstructive Cardiomyopathy><Hypertrophy><Idiopathic Hypertrophic Subvalvular Stenosis><Idiopathic hypertrophic subaortic stenosis><Inherited><Intermediary Metabolism><Intervention><Intracellular Communication and Signaling><Isotopes><Krebs Cycle><LVAD><Left Ventricles><Left ventricular structure><Medication><Mentors><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Methods><Mice><Mice Mammals><Mitochondria><Modern Man><Morbidity><Murine><Mus><Mutation><Myocardial><Myocardial Diseases><Myocardial Disorder><Myocardiopathies><Myocardium><Operative Procedures><Operative Surgical Procedures><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Pathogenicity><Pathologic><Patients><Pattern><Penetrance><Pharmaceutical Preparations><Phenotype><Physiologic><Physiological><Physiological Homeostasis><Physiology><Play><Position><Positioning Attribute><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Process><Production><Protein Modification><Publishing><Pyruvate><Recovery><Regulation><Reporting><Research><Role><Signal Transduction><Signal Transduction Systems><Signaling><Surgical><Surgical Interventions><Surgical Procedure><System><Systolic heart failure><TCA cycle><Testing><Therapeutic><Tissue Sample><Tracer><Tricarboxylic Acid Cycle><Vascular-Assist Devices><Ventricle-Assist Device><Waste Products><Work><adulthood><aorta constriction><balance><balance function><biological signal transduction><blood pump><cardiac dimension><cardiac failure><cardiac function><cardiac graft><cardiac hypertrophy><cardiac muscle><cardiac size><cardiac-assist devices><cardiomyocyte><cell metabolism><cellular metabaolism><chronic heart failure><defined contribution><developmental><drug/agent><environmental risk><experiment><experimental research><experimental study><experiments><extracellular><function of the heart><genome mutation><heart dimension><heart dimension/size><heart function><heart muscle><heart output><heart size><heart transplant><histone modification><hypertrophic myocardiopathy><implantation><inhibitor><left ventricular assist device><mitochondrial><mortality><mouse model><murine model><myocardium disease><myocardium disorder><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><non-histone protein><nonhistone protein><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><oxidation><pressure><programs><response><social role><stable isotope><surgery><transcriptomics><ventricular assist device>
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Zhaomeng Niu

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Developing and testing a mobile health intervention to promote sun protection behaviors and skin examination among Hispanics

Grant Number:

5R00MD016435-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2022

End Date:

1/31/2027

Project Abstract

ABSTRACT Skin cancer is the most common cancer in the United States (US). Melanoma is the deadliest form of skin cancer. In the past two decades, melanoma incidence among Hispanics has risen by 20%. The mortality rate of Hispanics is higher compared to Non-Hispanic whites (NHW). In general, compared...

Research Terms

<0-11 years old><Acculturation><Actinic Rays><Active Follow-up><Address><Adolescent><Adolescent Youth><Awareness><Behavior><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Benefits and Risks><Cancer Intervention><Cancers><Cell Phone><Cellular Phone><Cellular Telephone><Child><Child Youth><Children (0-21)><Communities><Conditioning Therapy><Cultural Assimilation><Data><Death Rate><Development><Diagnosis><Early Diagnosis><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Exposure to ultraviolet radiation><Focus Groups><Foundations><Funding><Future><Genomic Testing><Grant><Groups at risk><Health><Health Care Providers><Health Personnel><Health behavior><Hispanic><Hispanic Females><Hispanic Populations><Hispanic Women><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Incidence><Individual><Intervention><Interview><Jobs><Lifestyle Risk Reduction><Malignant Melanoma><Malignant Neoplasms><Malignant Skin Neoplasm><Malignant Tumor><Melanoma><Mentors><Mobile Phones><Multimedia><Multimedium><NCMHD><NIMHD><National Center on Minority Health and Health Disparities><National Institute of Minority Health and Health Disparities><National Institute on Minority Health and Health Disparities><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Nutrition><Occupational><Occupational Exposure><Occupations><Outcome><Participant><People at risk><Perception><Persons><Persons at risk><Phase><Physical activity><Pilot Projects><Population><Population Heterogeneity><Populations at Risk><Preparation><Prevent skin cancer><Preventive><Process><Professional Positions><Protocol><Protocols documentation><R-Series Research Projects><R01 Mechanism><R01 Program><Racial Group><Randomized, Controlled Trials><Reporting><Research><Research Grants><Research Project Grants><Research Projects><Risk><Risk Factors><Risk Reduction><Risk Reduction Behavior><Sampling><Self evaluation><Self-Examination><Self-Surveillance><Services><Skin><Skin Cancer><Suggestion><Sum><Sunblock><Sunscreening Agents><Sunscreens><Survey Instrument><Surveys><Survival Rate><Symptoms><Testing><Time><Training><Treatment Efficacy><UV Radiation Exposure><UV exposure><UV light><UV radiation><UV rays><Ultraviolet Radiation Related Exposure><Ultraviolet Rays><Ultraviolet radiation exposure><Underserved Population><United States><acceptability and feasibility><active followup><anti-cancer research><arm><behavior intervention><behavioral intervention><cancer research><career><cost><cost effective><determine efficacy><develop therapy><developmental><digital intervention><digital technology><disparity in health><diverse populations><early detection><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><ethnic subgroup><ethnicity group><evaluate efficacy><evidence base><examine efficacy><experience><follow up><follow-up><followed up><followup><genome based testing><genome testing><genomic DNA testing><genomic based testing><genomic clinical testing><genomic profiling testing><genomic screening test><health care personnel><health care worker><health disparity><health provider><health related behavior><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><heterogeneous population><hispanic community><iPhone><improved><improved outcome><industry involvement><information gathering><innovate><innovation><innovative><internet-based intervention><intervention development><intervention effect><intervention efficacy><intervention refinement><juvenile><juvenile human><kids><life-style risk reduction><mHealth therapeutic><mHealth therapy><mHealth treatment><malignancy><malignant skin tumor><medical care providers><medical personnel><member><mhealth interventions><mobile health intervention><mobile health therapeutic><mobile health therapy><mobile health treatment><mortality rate><neoplasm/cancer><participant engagement><patient engagement><pilot study><pilot test><population diversity><post intervention><preparations><prevent><preventing><programs><public health intervention><racial population><racial subgroup><randomized control trial><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><retention rate><retention strategy><risk-reducing><satisfaction><scale up><skin cancer prevention><smart phone><smartphone><social culture><socio-cultural><sociocultural><sun block><sun protection><sun safety><sun screen><theories><therapeutic efficacy><therapy development><therapy efficacy><treatment development><treatment provider><tumor><ultra violet light><ultra violet radiation><ultra violet rays><ultraviolet exposure><ultraviolet light><ultraviolet light exposure><ultraviolet radiation><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people><web-based intervention><workplace exposure><youngster>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Wei Zhang

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Light triggered materials for on-demand local anesthesia and tissue adhesive dissolution

Grant Number:

5R00GM141269-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

2/28/2027

Project Abstract

Project Summary Effective control of acute and chronic pain is a major medical challenge related to patients quality of life. Treatment with systemic medications is frequently associated with problems, such as addiction, illegal abuse and even death, leading to social problems and economic burden....

Research Terms

<Abscission><Absence of pain sensation><Absence of sensibility to pain><Acute Pain><Acutely painful><Adhesions><Adhesives><Anesthesia><Anesthesia procedures><Award><Benzodiazepine Compounds><Benzodiazepines><Binding><Biocompatible Materials><Biodistribution><Biomaterials><Body Tissues><Cancer Treatment><Cessation of life><Chemicals><Chemistry><Cicatrix><Common Rat Strains><Conduction-Blocking Anesthetics><Constipation><Crosslinker><Death><Development><Devices><Drug Delivery><Drug Delivery Systems><Drug Kinetics><Drug Prescribing><Drug Prescriptions><Drugs><Economic Burden><Encapsulated><Excision><Extirpation><Feels no pain><Formulation><Glues><Goals><H and E><Hematoxylin and Eosin><Hematoxylin and Eosin Staining Method><In Vitro><Inflammation><Itching><Laser Electromagnetic><Laser Radiation><Lasers><Light><Local Anesthetics><Local anesthesia><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Medical><Medication><Medicine><Mentors><Methods><Modeling><Molecular Interaction><Nausea><Nerve><Nerve Block><Neural Block><Neural Blockade><No sensitivity to pain><Operative Procedures><Operative Surgical Procedures><Opiates><Opioid><Opioid Analgesics><Pain><Pain Control><Pain Therapy><Pain management><Painful><Particulate><Patients><Pattern><Pharmaceutical Preparations><Pharmacokinetics><Phase><Photoradiation><Polymers><Position><Positioning Attribute><Property><Pruritic Disorder><Pruritis><Pruritus><QOL><Quality of life><Rat><Rats Mammals><Rattus><Reaction><Removal><Scars><Science><Series><Social Problems><Source><Staining method><Stains><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><System><Testing><Tetrazolium><Time><Tissue Adhesives><Tissues><Training><Work><Wound Repair><addiction><addictive disorder><analgesia><anti-cancer therapy><biocompatibility><biological material><biomaterial compatibility><cancer therapy><cancer-directed therapy><career><career development><chemical binding><chemical bond><chemical bound><chemical conjugate><chronic pain><crosslink><design><designing><developmental><drug/agent><efficacy study><empowerment><experience><functional group><imaging in vivo><improved><in vivo><in vivo imaging><innovate><innovation><innovative><interest><irradiation><itch sensation><light emission><mechanical properties><medication prescription><novel><opiate analgesia><opiate analgesic><opiate pain medication><opiate pain reliever><opioid analgesia><opioid anesthetic><opioid pain medication><opioid pain reliever><opioid painkiller><overdose death><overdose fatalities><pain intervention><pain relief><pain treatment><physical property><polymer><polymeric><prescribed medication><prevent><preventing><relieve pain><resection><response><safety study><sciatic nerve><side effect><skills><social disturbance><surgery><wound healing><wound recovery><wound resolution>
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Travis Bradley Lear

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Modulating Alzheimer's Disease by mTORC1 inhibition to augment lysosomal activity

Grant Number:

5R00AG078342-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2022

End Date:

12/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT: This proposal is in application for a Pathway to Independence Award for Dr. Travis Lear at the Aging Institute at the University of Pittsburgh. Dr. Lear has extensive experience in the molecular biology of ubiquitination in aging, inflammation, autophagy, and lysosome biolo...

Research Terms

<AD and related dementia><AD dementia><AD model><AD pathology><AD related dementia><AD therapy><AD treatment><ADRD><Affect><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease model><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease pathology><Alzheimer's disease related dementia><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's therapy><Alzheimers Dementia><Animal Model><Animal Models and Related Studies><Autophagocytosis><Award><Biogenesis><Biological><Biology><Biology of Aging><Brain><Brain Nervous System><CNS Nervous System><Care Givers><Caregivers><Cell Body><Cell Culture Techniques><Cell Line><Cell model><CellLine><Cells><Cellular model><Central Nervous System><Collection><Communities><Complex><DNA Molecular Biology><DNA Therapy><Data><Degenerative Neurologic Disorders><Drug Therapy><E3 Ligase><E3 Ubiquitin Ligase><Encephalon><Environment><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Future><Gene Transfer Clinical><Generations><Genes><Genetic><Genetic Intervention><Goals><Human><Impairment><In Vitro><Incidence><Inflammation><Intermediary Metabolism><Investigators><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Lead><Leadership><Lesion><Lysosomes><MAPT gene><MAPT protein><MT-bound tau><MTBT1><Mechanistic Target of Rapamycin><Mentors><Mentorship><Metabolic Processes><Metabolic Protein Degradation><Metabolism><Mice><Mice Mammals><Modeling><Modern Man><Molecular Biology><Murine><Mus><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neuraxis><Neurobiology><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Null Mouse><Origin of Life><Pathogenesis><Pathogenicity><Pathway interactions><Patients><Pb element><Pharmacological Treatment><Pharmacotherapy><Phenotype><Prevalence><Primary Senile Degenerative Dementia><Process><Protein Turnover><Proteins><RAFT1><Rapamune><Rapamycin><Regulatory Protein Degradation><Research><Research Personnel><Researchers><Risk Factors><Role><Route><Sirolimus><Stem Cell Development><Strains Cell Lines><Structure><System><Tau forming aggregates><Techniques><Testing><Therapeutic><Time><Toxic effect><Toxicities><Training><Ubiquitilation><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitination><Ubiquitinoylation><Universities><Upregulation><Work><aberrant tau><aberrant tau protein><abnormal tau><abnormal tau protein><abnormally aggregated tau protein><aged mice><aged mouse><ages><aggregation in tau><alzheimer model><autophagy><biologic><brain tissue><career><career development><cell culture><cell cultures><cognitive function><conference><convention><cultured cell line><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><demographics><detection of nutrient><drug intervention><drug treatment><elderly mice><experience><experiment><experimental research><experimental study><experiments><filamentous tau inclusion><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><heavy metal Pb><heavy metal lead><iPS><iPSC><iPSCs><improved><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><inhibitor><insight><insoluble aggregate><mTOR><mammalian target of rapamycin><microtubule associated protein tau><microtubule associated protein tau aggregation><microtubule associated protein tau deposit><microtubule associated protein tau mutation><microtubule bound tau><microtubule-associated protein tau><microtubule-associated protein tau mutation><microtubule-bound tau><model of animal><mouse model><murine model><mutant tau><mutant tau protein><mutation in microtubule associated protein tau><mutation in microtubule-associated protein tau><neural degeneration><neurobiological><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal><neuronal degeneration><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><nutrient sensing><old mice><paired helical filament of tau><pathogenic tau><pathogenic tau gene mutation><pathogenic tau protein><pathological change in tau><pathological tau><pathological tau protein><pathway><perception of nutrients><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pleiotropic effect><pleiotropism><pleiotropy><prevent><preventing><primary degenerative dementia><progenitor cell development><progenitor cell model><progenitor development><progenitor model><protein aggregate><protein aggregation><protein degradation><screening><screenings><self-aggregate tau><senile dementia of the Alzheimer type><skills><small molecule><social role><stem and progenitor cell development><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><summit><symposia><symposium><tau><tau PHF><tau Proteins><tau abnormality><tau accumulation><tau aggregate><tau aggregation><tau factor><tau fibrillation><tau fibrillization><tau filament><tau inclusion><tau intronic mutation><tau mutation><tau neurofibrillary tangle><tau oligomer><tau paired helical filament><tau pathological change><tau polymerization><tau protein accumulation><tau protein aggregation><tau-tau interaction><therapeutically effective><tissue culture><tool><ubiquination><ubiquitin conjugation><ubiquitin-protein ligase><τ Proteins><τ aggregation><τ mutation>
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Dana Nicole Shaw

UNIVERSITY OF NOTRE DAME, NOTRE DAME, IN

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Immune regulation of spinal cord regeneration

Grant Number:

4R00NS133484-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

12/31/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT Spinal cord injury in mammals triggers a cascade of cellular events that lead to the loss of sensory and motor function caudal to the site of injury. Following spinal cord injury, immune cells, including microglia and macrophages, infiltrate into the lesion site and become a...

Research Terms

<21+ years old><Ablation><Abscission><Adult><Adult Human><Amaze><Anatomic Sites><Anatomic structures><Anatomy><Automobile Driving><Axon><Behavior><Biologic Models><Biological Models><Blood><Blood Reticuloendothelial System><Blood leukocyte><Body Tissues><Brachydanio rerio><Cell Body><Cell Culture System><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Circulation><Communities><Complex><Danio rerio><Data><Environment><Event><Excision><Exhibits><Extirpation><Future><Gene Expression><Gene Transcription><Generalized Growth><Genes><Genetic><Genetic Transcription><Goals><Growth><Health><Hortega cell><Human><Image><Immune><Immune Cell Activation><Immune response><Immune system><Immunes><Immunomodulation><Infiltration><Injury><Laboratories><Lesion><Leukocytes><Leukocytes Reticuloendothelial System><Lineage Tracing><Macrophage><Mammalia><Mammals><Marrow leukocyte><Measures><Medulla Spinalis><Mice><Mice Mammals><Microglia><Model System><Modern Man><Molecular><Motor><Murine><Mus><Myelin><Mφ><Natural regeneration><Outcome><Pathway interactions><Patients><Phagocytes><Phagocytic Cell><Phagocytosis><Phase><Position><Positioning Attribute><Process><Protocol><Protocols documentation><RNA Expression><Recovery of Function><Regeneration><Regenerative capacity><Regenerative pathway><Removal><Role><SCI Patients><Sensory><Site><Spinal Cord><Spinal Cord Trauma><Spinal Trauma><Spinal cord injured><Spinal cord injury><Spinal cord injury patients><Subcellular Process><Surgical Removal><System><Techniques><Testing><Tissue Growth><Tissues><Training><Transcription><Traumatic Myelopathy><United States><Universities><Visualization><Washington><White Blood Cells><White Cell><Work><Wound Repair><Zebra Danio><Zebra Fish><Zebrafish><adulthood><amebocyte><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><design><designing><driving><experience><experiment><experimental research><experimental study><experiments><functional outcomes><functional recovery><gene function><gitter cell><healing><hiPSC><host response><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human tissue><imaging><immune activation><immune modulation><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunoneurology><immunoregulation><immunoregulatory><immunoresponse><improved><induced human pluripotent stem cells><injured><injuries><injury recovery><loss of function><medical college><medical schools><mesoglia><microglial cell><microgliocyte><mutant><nerve injury><neural injury><neuroimmunology><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ontogeny><overexpress><overexpression><pathway><perivascular glial cell><permissiveness><prevent><preventing><recovery after injury><recovery following injury><recovery post injury><regenerate><regeneration ability><regeneration capacity><regeneration function><regeneration pathway><regenerative><regenerative function><regenerative functionality><research faculty><resection><response><school of medicine><self-renew><self-renewal><social role><spinal cord regeneration><tenure process><tenure track><tissue repair><tool><white blood cell><white blood corpuscle><wound closure><wound healing><wound recovery><wound resolution>
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Marina Augusto Silveira

UNIVERSITY OF TEXAS SAN ANTONIO, SAN ANTONIO, TX

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

GABA and NPY Signaling Interact to Shape Inhibition in the Auditory Tectothalamic Pathway

Grant Number:

5R00DC019415-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2021

End Date:

12/31/2026

Project Abstract

Abstract Inhibition critically shapes auditory signal processing, impacting nearly every aspect of hearing. In the inferior colliculus (IC), inhibition shapes how neurons respond to auditory cues that are essential for speech and vocalization processing, including frequency tuning curves and directi...

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><Affect><Aging><Aminalon><Aminalone><Animal Vocalization><Auditory><Auditory Localization><Brain region><Cell Communication and Signaling><Cell Signaling><Communication><Complex><Critical Paths><Critical Pathways><Cues><Detection><Drug usage><Electrophysiology><Electrophysiology (science)><Elements><Equilibrium><Family><Foundations><Frequencies><GABA><Genetic><Glutamates><Goals><Hearing><In Vitro><Inferior Colliculus><Intracellular Communication and Signaling><Ipsilateral><L-Glutamate><Learning><Maps><Medial><Morphology><NPY-Y1 receptor><Nerve Cells><Nerve Transmitter Substances><Nerve Unit><Neural Cell><Neural Inhibition><Neurocyte><Neuromodulator><Neurons><Neuropeptide Tyrosine><Neuropeptides><Neurophysiology / Electrophysiology><Neurotransmitters><Outcomes Research><Pathway interactions><Pharmacology><Phase><Population><Position><Positioning Attribute><Posterior Quadrigeminal Body><Presbyacusis><Presbycusis><Property><Puffer Fish><Pufferfish><Puffers><Receptor Protein><Research><Role><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Sound Localization><Speech><Synapses><Synaptic><Testing><Tetraodontidae><Thalamic structure><Thalamus><Viral><Work><age associated hearing loss><age induced hearing loss><age related decline in hearing><age related hearing deficits><age related hearing impairment><age related hearing loss><aged mice><aged mouse><aging associated hearing loss><aging induced hearing loss><aging related decline in hearing><aging related hearing deficits><aging related hearing impairment><aging related hearing loss><auditory pathway><auditory processing><auditory thalamus><balance><balance function><biological signal transduction><drug use><elderly mice><electrophysiological><experiment><experimental research><experimental study><experiments><gamma-Aminobutyric Acid><glutamatergic><improved><in vivo><molecular biomarker><molecular marker><mouse model><murine model><neural><neural circuit><neural circuitry><neural control><neural regulation><neurocircuitry><neuromodulation><neuromodulatory><neuronal><neuronal excitability><neuropeptide Y><neuropeptide Y-Y1 receptor><neuropeptide YY1 receptor><neuroregulation><novel><old mice><optogenetics><pathway><postsynaptic><public health relevance><receptive field><receptor><response><signal processing><skills><social role><sound><speech processing><synapse><synapse inhibition><synaptic circuit><synaptic circuitry><synaptic inhibition><thalamic><therapeutic agent development><therapeutic development><vocalization><γ-Aminobutyric Acid>
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MURALI BAGALUR MUNIRAJU

TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO, EL PASO, TX

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Immune Evasion Mechanisms of KSHV Complement and Fc-Receptor Proteins

Grant Number:

5R00AI159139-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/12/2022

End Date:

12/31/2026

Project Abstract

PROJECT ABSTRACT Kaposi sarcoma-associated herpesvirus (KSHV) is the causal agent of Kaposi sarcoma, a cancer that appears as tumors on the skin or mucosal surfaces, and two types of B-cell lymphomas, multicentric Castleman disease and primary effusion lymphoma. As there are no vaccines or therapeut...

Research Terms

<7S Gamma Globulin><Address><Antibodies><Assay><Award><B lymphoma><B-Cell Lymphomas><BAC clone><BACs><Bacterial Artificial Chromosomes><Binding><Bioassay><Biological Assay><Cancers><Cell Body><Cell Line><CellLine><Cells><Complement><Complement Proteins><Complement Receptor><Complex><DNA mutation><Data><Development><Disease><Disease Progression><Disorder><Ensure><Fc Receptor><Foundations><Future><Genetic Change><Genetic defect><Genetic mutation><Glycoproteins><Goals><HHV-8><HHV8><Herpes infection><Herpesviridae><Herpesviridae Infections><Herpesviridae disease><Herpesvirus Infections><Herpesviruses><Host Defense><Host Factor><Host Factor Protein><Human><Human Herpesvirus 8><IgG><Immune><Immune Evasion><Immune Globulins><Immune system><Immunes><Immunobiology><Immunoglobulin G><Immunoglobulins><Immunophysiology><In Vitro><Infection><Integration Host Factors><Investigators><KSHV><Kaposi Sarcoma><Kaposi Sarcoma-Associated Herpes Virus><Kaposi Sarcoma-Associated Herpesvirus><Kaposi sarcoma associated virus><Kaposi sarcoma herpes virus><Kaposi's Sarcoma><Kaposi's sarcoma (KS)-associated herpesvirus><Knowledge><Malignant Neoplasms><Malignant Tumor><Measures><Mediating><Mentors><Modern Man><Molecular Interaction><Mucosa><Mucosal Tissue><Mucous Membrane><Multicentric Angiofollicular Lymphoid Hyperplasia><Multicentric Castleman's Disease><Multiple Hemorrhagic Sarcoma><Mutation><ORFs><Oncology><Oncology Cancer><Open Reading Frames><Pathogenesis><Phase><Preventative vaccine><Preventive vaccine><Prophylactic vaccine><Protein Coding Region><Proteins><Proteomics><Public Health><Reagent><Receptor Activation><Receptor Protein><Recombinants><Reporter><Reporting><Research><Research Personnel><Research Resources><Researchers><Resources><Role><Skin><Solid><Strains Cell Lines><Structure><Surface><System><Technology><Testing><Therapeutic><Training><Vaccines><Viral><Viral Antibodies><Virus><Virus-HHV8><Work><anti-viral antibody><antibody receptor><career><cell type><complement system><complementation><cultured cell line><decay acceleration><determine efficacy><developmental><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experience><genome mutation><herpes virus><immune evasive><immunoglobulin structure><kaposi's sarcoma herpesvirus><kaposi's sarcoma-associated human herpesvirus><malignancy><multicastleman's diseases><mutant><neoplasm/cancer><new approaches><novel><novel approaches><novel strategies><novel strategy><permissiveness><prevent><preventing><primary effusion lymphoma><receptor><receptor function><skills><social role><success><tumor><viral genomics><viral transmission><virus genomics><virus transmission>
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Jean-Paul Noel

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Neural and Computational Architecture for Complex Navigation and Subjective Self-Location

Grant Number:

5R00NS128075-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

11/30/2027

Project Abstract

Project Summary Candidate and Career Goals: I intend to become an independent scientist at a research-first academic institution, bridging across levels of description (i.e., from computations to neurons) and furthering our understanding of how the brain infers the world around us, as well as oursel...

Research Terms

<ASD><Accounting><Adaptive Behaviors><Ammon Horn><Animals><Architecture><Area><Autism><Autistic Disorder><Award><Behavior><Behavioral><Belief><Biologic Psychiatry><Biological><Biological Psychiatry><Body Buffer Zone><Brain><Brain Nervous System><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Code><Coding System><Cognition><Cognitive><Cognitive Science><Communication><Complement><Complement Proteins><Complex><Cornu Ammonis><Coupling><Darkness><Data Collection><Data Science><Development Plans><Disease><Disorder><Disparities><Disparity><Early Infantile Autism><Encephalon><Engineering / Architecture><Environment><Feedback><Fireflies><Foundations><Genetic Diversity><Genetic Variation><Goals><Grant><Health><Hippocampal Formation><Hippocampus><Human><Human Resources><Illusions><Infantile Autism><Institution><International><Intracellular Communication and Signaling><Kanner's Syndrome><Knowledge><Lampyridae><Link><Location><Manpower><Maps><Measures><Mediating><Mentors><Mice><Mice Mammals><Modeling><Modern Man><Motion><Motor><Movement><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurosciences><Personal Space><Phase><Photons><Physiology><Position><Positioning Attribute><Privacy of Space><Prize><Process><Research><Retina><Rodent><Rodent Model><Rodentia><Rodents Mammals><Schizophrenia><Schizophrenic Disorders><Scientist><Sensory><Signal Transduction><Signal Transduction Systems><Signaling><Skull><System><Techniques><Technology><Testing><Training><Visual Motion><Work><Writing><adaptation behavior><adaptive behavior><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><biologic><biological signal transduction><body movement><career><career development><cognitive psychology><complementation><cranium><dementia praecox><design><designing><experience><hippocampal><member><mouse model><multisensory><murine model><neglect><neural><neural circuit><neural circuitry><neurocircuitry><neuronal><neurophysiological><neurophysiology><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><non-human primate><nonhuman primate><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><object motion><optic flow><personnel><phenomenological models><phenomenology><place fields><preference><receptive field><schizophrenic><skills><spatial navigation><synaptic circuit><synaptic circuitry><virtual><virtual reality><visual motor><visuomotor><way finding><wayfinding>
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Christopher Zimmerman

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Cross-region neural mechanisms that support conditioned taste aversion

Grant Number:

4R00DA059957-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2023

End Date:

12/31/2028

Project Abstract

PROJECT SUMMARY Eating and drinking are rapid processes, but their postingestive effects are slow and delayed. How do animals correctly associate these delayed effects (detection of nutrients or toxins in the gut) with transient stimuli like tastes and smells that precede them by minutes or hours? T...

Research Terms

<Active Follow-up><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Anatomic Sites><Anatomic structures><Anatomy><Animals><Axon Terminals><Behavior Control><Behavioral Manipulation><Brain><Brain Nervous System><Brain region><Cell Communication and Signaling><Cell Signaling><Chronic><Clinical><Code><Coding System><Computational toolkit><Conditioned Taste Aversion><Consumption><Data><Development><Dysfunction><Eating><Eating Disorders><Electrophysiology><Electrophysiology (science)><Encephalon><Exclusion><FBJ osteosarcoma oncogene><FOS gene><Feedback><Food><Food Intake><Food Preferences><Functional disorder><G0S7><Genetic><Goals><Gustation><Hour><Human><Hypothalamic structure><Hypothalamus><Image><Immediate-Early Genes><Implant><Intracellular Communication and Signaling><Label><Lateral><Learning><Link><Machine Learning><Malaise><Measures><Memory><Mice><Mice Mammals><Mission><Modeling><Modern Man><Motivation><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Neurosciences Research><Nutrient><Nutrient-dense food><Nutritious-dense food><Obesity><Odors><Olfaction><Pathway interactions><Pattern><Phase><Physiopathology><Population><Positive Valence><Postdoc><Postdoctoral Fellow><Presynaptic Nerve Endings><Presynaptic Terminals><Process><Protooncogene FOS><Research Associate><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Smell><Smell Perception><Stimulus><Stomach><Survey Instrument><Surveys><Synapses><Synaptic><Synaptic Boutons><Synaptic Terminals><Synaptic plasticity><Taste><Taste Perception><Taste aversion><Taste preferences><Technical Expertise><Techniques><Testing><Toxin><Training><Transgenic Organisms><Ventral Striatum><Visceral><With laterality><active followup><adiposity><amygdaloid nuclear complex><behavioral control><biological signal transduction><c fos><c-fos Gene><c-fos Proto-Oncogenes><chemotherapy><computational toolbox><computational tools><computational toolset><computerized tools><corpulence><density><detection of nutrient><developmental><diet choice><diet preference><dietary choice><dietary preferences><drinking><electrophysiological><experience><experiment><experimental research><experimental study><experiments><follow up><follow-up><followed up><followup><food choice><gastric><gustatory perception><gustatory processing><gustatory response><hypothalamic><imaging><innovate><innovation><innovative><insight><machine based learning><neural><neural mechanism><neuromechanism><neuronal><novel><nutrient rich food><nutrient rich meal><nutrient sensing><nutrient-dense meal><odor perception><olfactory perception><optogenetics><pathophysiology><pathway><perception of nutrients><post-doc><post-doctoral><post-doctoral trainee><preference><prevent><preventing><recruit><research associates><synapse><taste processing><taste response><technical skills><theories><tool><transgenic><v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog><virtual>
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Oleta Tanitrea Johnson

MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CAMBRIDGE, MA

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Developing Tools to Probe DnaJB6 Dynamics in Spinobulbular Muscular Atrophy

Grant Number:

5R00NS128717-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2022

End Date:

11/30/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Spinobulbar Muscular Atrophy (SBMA) is an incurable neurodegenerative disorder that is characterized by the toxic accumulation of mutated androgen receptor (polyQ-AR) proteins. The molecular chaperone protein DnaJB6 is specialized to prevent polyQ-AR aggregation in cells an...

Research Terms

<ATP phosphohydrolase><ATPase><Adenosine Triphosphatase><Androgen Receptor><Animal Model><Animal Models and Related Studies><Assay><Award><Binding><Bioassay><Biochemical><Biological Assay><Biology><Biophysics><Bulbospinal Neuronopathy><C10><Cell Body><Cell model><Cells><Cellular model><Chaperone><Chemicals><Complex><Degenerative Neurologic Disorders><Disease Progression><Dominantly-Inherited Spinocerebellar Ataxias><Drug Targeting><Electron Microscopy><Future><Genetic Diseases><Goals><Homo><Huntington Chorea><Huntington Disease><Huntington's><Huntington's Disease><Huntingtons Disease><In Vitro><Kennedy Syndrome><Kennedy's Disease><Libraries><Ligands><Maps><Methods><Modeling><Molecular><Molecular Chaperones><Molecular Dynamics Simulation><Molecular Interaction><Molecular Sieve Chromatography><Muscle Atrophy><Muscular Atrophy><Mutate><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Paralysis Agitans><Parkinson><Parkinson Disease><Pathologic><Peptides><Phase><Photometry><Poly Q><Primary Parkinsonism><Protein Dynamics><Proteins><Receptor Protein><Role><Scanning><Site><Size Exclusion Chromatography><Solvents><Spinobulbar Atrophy><Spinobulbar Muscular Atrophy><Spinocerebellar Ataxias><Spinocerebellar Atrophies><Structure><Structure-Activity Relationship><Surface Plasmon Resonance><System><Techniques><Testing><Therapeutic><Time><Toxic effect><Toxicities><Training><Work><X-Linked Bulbo-Spinal Atrophy><biophysical foundation><biophysical principles><biophysical sciences><chemical structure function><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><disease phenotype><genetic condition><genetic disorder><improved><in vitro activity><innovate><innovation><innovative><insoluble aggregate><light scattering><model of animal><molecular dynamics><mouse model><murine model><muscle breakdown><muscle degradation><muscle deterioration><muscle loss><muscle wasting><mutant><neurodegenerative illness><neuromuscular><new approaches><novel><novel approaches><novel strategies><novel strategy><polyQ><polyglutamine><prevent><preventing><protein aggregate><protein aggregation><protein homeostasis><protein protein interaction><proteostasis><receptor><recruit><small molecule><social role><spinal and bulbar muscular atrophy><structure function relationship><tool>
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PIOTR KONIECZNY

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Decoding the repair and immunomodulatory functions of lymphatic vessels in wound healing

Grant Number:

4R00AR083536-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2029

Project Abstract

PROJECT SUMMARY Proper skin restoration after the damage is vital for organismal survival. The lymphatic vascular system is spread throughout the human body and has a critical function in mammalian physiology. In physiological conditions, its main function is the regulation of tissue drainage, immun...

Research Terms

<Address><Affect><Behavior><Biology><Blood><Blood Reticuloendothelial System><Blood capillaries><Body Tissues><C3 convertase activator><C3PA Convertase><C3PAse><Cell Body><Cells><Cellular Immune Function><Chronic><Clinical><Communication><Complement Factor D><Complement Protein D><Complex><Corium><Cutis><D component of complement><Data><Dermal><Dermis><Development Plans><Development and Research><Drainage><Drainage procedure><Epidermis><Epithelium><FIGF protein><FLT4 Ligand><FLT4-L><Factor D><Fibroblasts><Fibrosis><Foundations><Future><GBGase><Gene Expression><Generalized Growth><Genomics><Grant><Growth><Growth Agents><Growth Factor><Growth Substances><Hair Follicle><Hair follicle structure><Healing abnormal><Healing delayed><Human Figure><Human body><Image><Immune><Immune Surveillance><Immune infiltrates><Immune response><Immunes><Immunologic Surveillance><Immunomodulation><Immunosurveillance><Impaired healing><Inflammation><Injury><Intercellular Fluid><Interstitial Fluids><Investigators><Knowledge><Link><Liquid substance><Lymph><Lymph System><Lymphangiogeneses><Lymphangiogenesis><Lymphatic><Lymphatic Network><Lymphatic System><Lymphatic System Reticuloendothelial System><Lymphatic function><Lymphedema><Macrophage><Mediating><Medical><Mentors><Mice><Mice Mammals><Modeling><Molecular><Murine><Mus><Mφ><Natural regeneration><Pathologic><Patients><Peptides><Persons><Phase><Physiologic><Physiological><Physiology><Position><Positioning Attribute><Prevalence><Proactivator Convertase><Process><Production><Productivity><Progenitor Cells><Properdin Factor D><Proteins><Proteins Growth Factors><R & D><R&D><Regeneration><Regulation><Research><Research Personnel><Researchers><Role><Skin><Skin repair><Source><Swelling><Technology><Testing><Therapeutic><Tissue Growth><Tissues><Ulcer><Ulceration><VEGF-C><VEGF-D><Vascular Endothelial Growth Factor C><Vascular Endothelial Growth Factor D><Vascular Endothelial Growth Factor Related Protein><Vascular System><Wound Repair><Writing><adipocyte 28 kDa protein><adipsin><c-fos-induced growth factor><capillary><career><career development><chronic skin wound><chronic ulcer><chronic wound><cutaneous repair><cutaneous wound><cytokine><dermal repair><dermal wound><differentiation factors><epidermal progenitor><epidermal progenitor cell><epidermal stem cell><epithelial repair><epithelial wound><experiment><experimental research><experimental study><experiments><fluid><fluid flow><healing><host response><imaging><immune cell infiltrate><immune function><immune modulation><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><improved><injuries><innovate><innovation><innovative><interstitial><liquid><lymph channel><lymph edema><lymph vessel><lymphatic channel><lymphatic circulation><lymphatic drainage><lymphatic dysfunction><lymphatic edema><lymphatic fluid><lymphatic impairment><lymphatic transport><lymphatic vessel><morphogenic factors><morphogens><mouse model><multidisciplinary><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><non-healing ulcer><non-healing wounds><nonhealing ulcer><nonhealing wounds><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ontogeny><persistent wounds><pressure><programs><re-epithelialization><recruit><regenerate><regeneration function><regenerative function><regenerative functionality><repair><repaired><research and development><response><restoration><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skin wound><social role><stem cells><tissue repair><tissue wound><tool><treat wound><wound><wound closure><wound healing><wound management><wound recovery><wound resolution><wound therapeutics><wound therapy><wound treatment><wounding><wounds>
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Caroline M. Kelsey

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Neural Markers of Developmental Delays in Premature and Full Term Infants

Grant Number:

4R00HD115830-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2029

Project Abstract

Project Summary/Abstract Premature infants are vulnerable to long-term social, cognitive, and behavioral difficulties. However, not all premature infants go on to have developmental delays. Moderate to late preterm infants (born after 32 weeks) represent a missed clinical population as they do not a...

Research Terms

<0-11 years old><4 year old><4 years of age><ASD><Active Follow-up><Age><Autism><Autism Diagnosis><Autistic Disorder><Award><Behavioral><Biological Markers><Blood Coagulation Factor I><Blood Coagulation Factor One><Blood Factor One><Blood flow><Brain><Brain Nervous System><Cerebrovascular Circulation><Child><Child Youth><Children (0-21)><Chronology><Clinic><Clinical><Coagulation Factor I><Coagulation Factor One><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collection><Data><Development><Developmental Delay><Developmental Delay Disorders><Diagnosis><Disturbance in cognition><EEG><Early Infantile Autism><Early Intervention><Early identification><Electroencephalogram><Electroencephalography><Encephalon><Enrollment><Equilibrium><Factor I><Factor One><Faculty><Fibrinogen><Funding><Future><Gestation><Goals><Grant><Health><Health Care Facility><Health Facilities><Hemoglobin><Heterogeneity><Impaired cognition><Impairment><Infant><Infantile Autism><Interruption><Intervention Strategies><Investigation><Investigators><Kanner's Syndrome><Language><Learning><Life><Link><Measures><Mediating><Medical><Metabolic><Methods><Mission><Motor><NICHD><National Institute of Child Health and Human Development><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neurocyte><Neurons><Nutrient><O element><O2 element><Oxygen><Participant><Pattern><Personal Satisfaction><Phase><Population><Position><Positioning Attribute><Pregnancy><Premature Birth><Premature Infant><Prematurely delivering><Preterm Birth><Primary Care><Process><Property><Public Health><Qualifying><Questionnaires><Research><Research Personnel><Researchers><Resolution><Rest><Sampling><Services><Social Development><Specific Child Development Disorders><Synaptic Potentials><Techniques><Testing><Theoretic Models><Theoretical model><Time><Training><United States><Visit><Vulnerable Populations><Well baby checks><Well baby checkups><Well baby visits><active followup><age 4><age 4 years><ages><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><balance><balance function><behavioral impairment><bio-markers><biologic marker><biomarker><blood flow in brain><brain blood circulation><brain blood flow><candidate biomarker><candidate marker><care facilities><cerebral blood flow><cerebral circulation><cerebrocirculation><cerebrovascular blood flow><cognitive development><cognitive dysfunction><cognitive loss><cost><developmental><developmental disease><developmental disorder><early childhood><enroll><experience><fNIRS><follow up><follow-up><followed up><followup><four year old><four years of age><frontal cortex><frontal lobe><functional near infrared spectroscopy><high risk><high risk infant><impaired behavior><improved><indexing><infant well check><infant well visits><infants born premature><infants born prematurely><intervention program><kids><life span><lifespan><multi-modality><multimodality><neural><neural imaging><neural mechanism><neuro-imaging><neuro-vascular><neuro-vascular coupling><neurodevelopment><neuroimaging><neurological imaging><neuromechanism><neuronal><neurovascular><neurovascular coupling><novel><postsynaptic><premature><premature baby><premature childbirth><premature delivery><premature infant human><prematurity><preterm baby><preterm delivery><preterm infant><preterm infant human><primary care clinic><primary care visit><programs><psychological outcomes><recruit><resolutions><response><response to therapy><response to treatment><screening program><social><synapse formation><synaptogenesis><temporal measurement><temporal resolution><therapeutic response><therapy response><time measurement><tool><treatment response><treatment responsiveness><vulnerable group><vulnerable individual><vulnerable infant><vulnerable people><well-being><wellbeing><youngster>
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Akos Nyerges

HARVARD MEDICAL SCHOOL, BOSTON, MA

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Development of a Gene-Transfer-Resistant and Biocontained Next-Generation Bacterial Host for Controlled Drug Delivery

Grant Number:

4R00EB035165-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/22/2023

End Date:

1/31/2029

Project Abstract

Synthetic biology transformed our ability to rationally reprogram cells and use such engineered living organisms, instead of small-molecule drugs or biologics, as novel therapeutics. However, living therapeutics proliferate and release their engineered genetic information into natural biomes through...

Research Terms

<Address><Advisory Committees><Alimentary Canal><Amino Acids><Amino Acyl T RNA Synthetases><Amino Acyl-tRNA Ligases><Amino Acyl-tRNA Synthetases><Aminoacyl Transfer RNA Synthetase><Aminoacyl-tRNA Synthetase><Ammonia><Animal Model><Animal Models and Related Studies><Autoimmune Diseases><Award><Bacteria><Bacteria resistance><Bacteria resistant><Bacterial resistant><Biological Agent><Biological Products><Cancers><Cell Body><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cell Survival><Cell Viability><Cells><Cellular Expansion><Cellular Growth><Cellular Proliferation><Chronic><Chronic Disease><Chronic Illness><Clinical><Development><Digestive Tract><Disease><Disorder><Dose><Drug Delivery><Drug Delivery Systems><Drug Kinetics><Drugs><E coli><E. coli><Engineering><Environment><Enzyme Gene><Enzymes><Escherichia coli><Excretory function><Food Supplements><Foundations><GI Tract><GI colonization><GMO Organisms><Gastrointestinal Tract><Gastrointestinal tract structure><Gene Expression><Gene Transfer><Generalized Growth><Generations><Genes><Genetic><Genetic Code><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetically Modified Organisms><Goals><Growth><Half-Life><Health><Hereditary><Hereditary Tyrosinemias><Horizontal Gene Transfer><Human><Human Figure><Human body><Inherited><Lateral Gene Transfer><Link><Lyase><Lyase Gene><Malignant Neoplasms><Malignant Tumor><Medication><Mentors><Metabolic Diseases><Metabolic Disorder><Mice><Mice Mammals><Modern Man><Murine><Mus><NIH><National Institutes of Health><Organism><Patients><Peptide-based drug><Pharmaceutical Preparations><Pharmacokinetics><Phase><Predatory Behavior><Prevention><Production><Proliferating><Proteomics><Recombinant DNA Technology><Research><Resistance><Risk><Role><Safety><Sense Codon><Stop Codon><Supplementation><System><Task Forces><Technology><Termination Codon><Terminator Codon><Testing><Therapeutic><Therapeutic Uses><Thesaurismosis><Tissue Growth><Training><Transfer RNA><Transfer RNA Synthetase><Transgenes><Translating><Translation Stop Signal><Triplet Codon-Amino Acid Adaptor><Tyrosine><Tyrosinemias><United States National Institutes of Health><Viral><Viral Diseases><Viral Genes><Virus><Virus Diseases><Work><addiction><addictive disorder><advisory team><alimentary tract><aminoacid><aminoacid tRNA ligase><autoimmune condition><autoimmune disorder><autoimmunity disease><bacterial resistance><biologics><biopharmaceutical><biotherapeutic agent><career development><cell growth><chronic disorder><clinical translation><clinically translatable><colonization resistance><developmental><digestive canal><drug production><drug/agent><excretion><experiment><experimental research><experimental study><experiments><firewall><gastrointestinal tract colonization><gene function><gene therapeutics><gene-based therapeutic><gene-based therapeutics><genes therapeutic><genes therapeutics><genetic information><genetic results><genetic testing results><genetically engineered><gut colonization><in vivo><intestinal colonization><living system><malignancy><metabolism disorder><microbial><microbial host><microbiome><microorganism><model of animal><mouse model><murine model><neoplasm/cancer><new drug treatments><new drugs><new pharmacological therapeutic><new technology><new therapeutics><new therapy><next generation><next generation therapeutics><non-natural amino acids><non-proteinogenic amino acids><nonproteinogenic amino acids><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel technologies><novel therapeutics><novel therapy><ontogeny><peptide drug><predation><prevent><preventing><programs><resistance to Bacteria><resistance to Bacterial><resistant><resistant to Bacteria><resistant to Bacterial><small molecule><social role><synthetic DNA><synthetic biology><synthetic construct><tRNA><tRNA Synthetase><therapeutic agent development><therapeutic development><therapeutic enzyme><therapeutic gene><therapeutic peptide><therapeutic transgene><transfer Ribonucleic acids><transgene><unnatural amino acids><viral infection><viral resistance><virus host interaction><virus infection><virus resistance><virus-induced disease>
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Marcos Matamoros Campos

TEXAS TECH UNIVERSITY HEALTH SCIS CENTER, LUBBOCK, TX

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

K+ channel structural dynamics landscape: from selectivity to gating

Grant Number:

4R00GM147529-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2029

Project Abstract

K+ channel structural dynamics landscape: from selectivity to gating The chemical and electrical activities that make life possible are controlled by a constellation of ion channels. These are transmembrane proteins that regulate the differential concentration of ions across the cell membrane, with,...

Research Terms

<Action Potentials><Address><Adopted><Amino Acids><Arrhythmia><Axon><Behavior><Biophysics><Body Tissues><Cancers><Cardiac Arrhythmia><Cell Body><Cell Communication and Signaling><Cell Membrane Lipids><Cell Signaling><Cell membrane><Cells><Charge><Chemicals><Complex><Conduction-Blocking Anesthetics><Cryo-electron Microscopy><Cryoelectron Microscopy><Crystallographies><Crystallography><Cytoplasm><Cytoplasmic Membrane><DNA mutation><Data><Development><Disease><Disorder><Drug Design><Drugs><Dysfunction><Electron Cryomicroscopy><Electrophysiology><Electrophysiology (science)><Environment><FRET><Family><Fluorescence Resonance Energy Transfer><Functional disorder><Förster Resonance Energy Transfer><Generations><Genetic Change><Genetic defect><Genetic mutation><Goals><Health><Heart Arrhythmias><Image><Inflammation><Integral Membrane Protein><Intracellular Communication and Signaling><Intrinsic Membrane Protein><Investigators><Ion Channel><Ionic Channels><Ions><K channel><K element><Label><Lead><Life><Local Anesthetics><Malignant Neoplasms><Malignant Tumor><Mechanical Stress><Medication><Membrane Channels><Membrane Lipids><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Mentors><Methods><Migraine><Migraine Headache><Modeling><Molecular><Molecular Configuration><Molecular Conformation><Molecular Dynamics Simulation><Molecular Stereochemistry><Movement><Mutation><Neurophysiology / Electrophysiology><Organism><Pain><Painful><Pathologic><Pathology><Pb element><Pharmaceutical Preparations><Phase><Phosphorylation><Physiologic><Physiological><Physiopathology><Plasma Membrane><Play><Position><Positioning Attribute><Potassium><Potassium Channel><Potassium Ion Channels><Protein Dynamics><Protein Phosphorylation><Proteins><Regulation><Research><Research Personnel><Researchers><Resolution><Role><Signal Transduction><Signal Transduction Systems><Signaling><Structural Biologist><Structure><Surface Proteins><TM Domain><Techniques><Temperature><Testing><Time><Tissues><Training><Transmembrane Domain><Transmembrane Protein><Transmembrane Protein Gene><Transmembrane Region><VHH><VHH antibody><Work><aminoacid><biological signal transduction><biophysical foundation><biophysical principles><biophysical sciences><body movement><camelid antibody><camelid based antibody><camelid derived antibody><camelid derived fragment><camelid heavy chain only Abs><camelid immunoglobulin><camelid single chain antibody><camelid variable heavy chain><conformation><conformational><conformational state><conformationally><conformations><constriction><cryo-EM><cryoEM><cryogenic electron microscopy><design><designing><developmental><drug/agent><electrophysiological><experience><experiment><experimental research><experimental study><experiments><extracellular><field based data><field learning><field study><field test><flexibility><flexible><genome mutation><heavy metal Pb><heavy metal lead><human disease><imaging><insight><interest><ion dynamics><living system><malignancy><molecular dynamics><nanobodies><nanobody><neoplasm/cancer><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><non-Native><nonnative><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><pathophysiology><pharmacologic><plasmalemma><pressure><resolutions><sdAb><single domain antibodies><single molecule><single-molecule FRET><single-molecule fluorescence resonance energy transfer><skills><smFRET><social role><therapeutic target><tool><variable heavy chain antibody><voltage>
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Xinxing Zhang

UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR, OKLAHOMA CITY, OK

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Identification of novel osmosensing receptors in C. elegans

Grant Number:

5R00GM141267-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2021

End Date:

1/31/2027

Project Abstract

Project Summary The ability to sense osmolarity changes and maintain fluid osmolarity is required for normal physiological functions of every single cell and thus vital for human health. Fluid imbalance, caused by high osmolarity (hyperosmolarity) or low osmolarity (hypoosmolarity), can lead to irre...

Research Terms

<Address><Animals><Autoregulation><Award><Behavioral><Biochemistry><Biological Chemistry><Blood><Blood Reticuloendothelial System><Body Fluids><Brain><Brain Nervous System><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><Calcium><Categories><Cell Body><Cell Culture Techniques><Cells><Chemicals><Cryo-electron Microscopy><Cryoelectron Microscopy><Detection><Disease><Disorder><Electron Cryomicroscopy><Electrophysiology><Electrophysiology (science)><Elements><Encephalon><Family><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><GeneHomolog><Generations><Genetic><Genetic Screening><Gustation><Health><Hearing><Homeostasis><Homolog><Homologous Gene><Homologue><Human><Image><In Vitro><Investigators><Knowledge><Lead><Life><Liquid substance><Mammalia><Mammalian Cell><Mammals><Mediating><Mentors><Modality><Modeling><Modern Man><Molecular><Molecular Genetics><Nature><Nematoda><Nematodes><Nerve Cells><Nerve Unit><Nervous System Injuries><Nervous System Trauma><Nervous System damage><Neural Cell><Neural Receptors><Neurocyte><Neurological Damage><Neurological Injury><Neurological trauma><Neurons><Neurophysiology / Electrophysiology><Neuroreceptors><Olfaction><Organ><Organism><Osmolar Concentration><Osmolarity><Osmoregulation><Osmosis><Pb element><Phase><Photons><Physiologic><Physiological><Physiological Homeostasis><Property><Proprioception><Receptor Protein><Regulation><Research><Research Personnel><Researchers><Rodent><Rodentia><Rodents Mammals><Sensory><Sensory Receptors><Sight><Signaling Molecule><Smell><Smell Perception><Stimulus><Structure><System><TRP channel><Taste><Taste Perception><Temperature><Testing><Thirst><Time><Touch><Touch sensation><Training><Transient receptor potential channel><Vision><Work><avoidance behavior><career><cell culture><cell cultures><continuous monitoring><cryo-EM><cryoEM><cryogenic electron microscopy><design><designing><drinking behavior><electrophysiological><falls><fluid><gustatory perception><gustatory processing><gustatory response><heavy metal Pb><heavy metal lead><human disease><imaging><in vivo><insight><interdisciplinary approach><liquid><living system><mechanical force><multidisciplinary approach><mutant><neural><neuronal><neurotrauma><novel><odor perception><olfactory perception><perceptual stimulus><physicochemical phenomena related to the senses><post-doctoral training><receptor><roundworm><screening><screenings><sensory stimulus><skill acquisition><skill development><tactile sensation><taste processing><taste response><tool><visual function>
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SIERRA STRINGFIELD

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Investigating the lasting effects of adolescent cannabinoid exposure on mesocortical development

Grant Number:

5R00DA054205-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2022

End Date:

11/30/2027

Project Abstract

Project Abstract Adolescence is a period of significant neuronal development as well as the time when many individuals initiate cannabis use. Delta-9-tetrahydrocannabinol (THC) is one of the main psychoactive components found in cannabis, and THC exposure during adolescence has previously been assoc...

Research Terms

<12-20 years old><21+ years old><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><9-ene-Tetrahydrocannabinol><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Aminalon><Aminalone><Animals><Applied Skills><Award><Behavior><Behavioral><Biosensor><Brain region><CB1><CB1 Receptor><CB1R><CNR1 gene><Cannabinoid Receptor CB1><Cannabinoids><Cannabis><Cell Communication and Signaling><Cell Signaling><Clinical Research><Clinical Study><Cognitive><Cognitive deficits><Common Rat Strains><Complex><Confocal Microscopy><Connector Neuron><D9-tetrahydrocannabinol><DA Neuron><Data><Delta-9-Tetrahydrocannabinol><Development><Differences between sexes><Differs between sexes><Dopamine neuron><Dopaminergic Cell><Dose><Drug Exposure><Drug abuse><Drug usage><Electrophysiology><Electrophysiology (science)><Exhibits><Exposure to><Faculty><Female><Fiber><Foundations><Future><GABA><Grant><History><Image><Immediate Memory><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impairment><Individual><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intracellular Communication and Signaling><Intravenous><Investigation><Label><Learning><Long-Term Effects><Measures><Mentors><Methods><Microscopy><Molecular><Nerve Impulse Transmission><Nerve Transmission><Nerve Transmitter Substances><Neuronal Transmission><Neurophysiology / Electrophysiology><Neurotransmitters><Performance><Phase><Photometry><Prefrontal Cortex><Preparation><Psychological reinforcement><Pyramidal neuron><R-Series Research Projects><R01 Mechanism><R01 Program><Rat><Rats Mammals><Rattus><Receptor Protein><Recording of previous events><Reinforcement><Research Grants><Research Project Grants><Research Projects><Rodent Model><Role><Sampling><Schedule><Self Administered><Self Administration><Series><Sex Differences><Sexual differences><Short-Term Memory><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Structure><Synapses><Synaptic><System><THC co-use><THC exposure><THC use><Techniques><Testing><Tetrahydrocannabinol><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Time><Training><Ventral Tegmental Area><abuse of drugs><abuses drugs><adolescence (12-20)><adulthood><axon signaling><axon-glial signaling><axonal signaling><behavior influence><behavior outcome><behavioral influence><behavioral outcome><biological sensor><biological signal transduction><cannabinoid receptor><cannabinoid receptor 1><cannabinoid receptor type 1><cannabinoid type 1><cannabis use><career><cell type><cognitive defects><cognitive function><cognitive task><cognitive training><delta(1)-THC><delta(1)-Tetrahydrocannabinol><delta(9)-THC><delta(9)-Tetrahydrocannabinol><density><developmental><dopaminergic neuron><drug use><electrophysiological><executive control><executive function><experience><experiment><experimental research><experimental study><experiments><gamma-Aminobutyric Acid><glia signaling><glial signaling><hippocampal pyramidal neuron><histories><imaging><improved><in vivo><indexing><insight><juvenile><juvenile human><male><marijuana use><nerve signaling><neural signaling><neuron development><neuronal development><neuronal patterning><neuronal signaling><neurotransmission><optogenetics><postsynaptic><pre-clinical research><preclinical research><preparations><presynaptic><receptor><receptor expression><response><sex><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><skills><social role><synapse><tetrahydrocannabinol exposure><ventral tegmentum><working memory><Δ(1)-THC><Δ(1)-tetrahydrocannabinol><Δ(9)-THC><Δ(9)-tetrahydrocannabinol><Δ-9-tetrahydrocannabinol><Δ9-tetrahydrocannabinol><γ-Aminobutyric Acid><♀><♂>
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Zhiyong Liu

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Exploratory lead · 16/100
Active award
$248,999
FY 2026

Project Title

Role of Rab10 in Alzheimer's disease

Grant Number:

5R00AG075179-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2022

End Date:

12/31/2026

Project Abstract

1 Project Summary: “Role of Rab10 in Alzheimer’s disease, K99/R00” 2 Candidate: My long-term career goals center on the establishment of a leading research laboratory in 3 academia focused on defining key molecular mechanisms underlying neurodegeneration and Alzheimer’s 4 disease (AD). Specifical...

Research Terms

<3' Untranslated Regions><3'UTR><AD brain><AD dementia><AD model><AD patients><APOE e4><APOE-ε4><APOEε4><Academia><Acceleration><Acute><Advisory Committees><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's brain><Alzheimer's disease brain><Alzheimer's disease model><Alzheimer's disease patient><Alzheimer's patient><Alzheimers Dementia><Animal Model><Animal Models and Related Studies><Atrophic><Atrophy><Attenuated><Automobile Driving><Biochemistry><Biological Chemistry><Biology><Biophysics><Brain><Brain Nervous System><Cell Body><Cells><Cellular biology><Coupled><Cross-Product Ratio><Data><Degenerative Neurologic Disorders><Diathesis><Disease><Disease Progression><Disease susceptibility><Disorder><Dysfunction><Encephalon><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Foundations><Functional disorder><Future><GAP Proteins><GDP Dissociation Factor><GDP Dissociation Stimulators><GDP Exchange Factors><GDP-GTP Exchange Protein><GDP-GTP Reversing Factors><GTP><GTP Binding><GTP GDP exchange factor><GTP Phosphohydrolases><GTP bound><GTPase-Activating Proteins><GTPases><Genetic><Genetic Diversity><Genetic Variation><Goals><Grant><Guanine Nucleotide Exchange Factors><Guanine Nucleotide Exchange Protein><Guanine Nucleotide Releasing Factors><Guanosine Triphosphate><Guanosine Triphosphate Phosphohydrolases><Guanosinetriphosphatases><Guanyl-Nucleotide Exchange Factor><Guanyl-Nucleotide Releasing Factor><Hortega cell><Immune response><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><In Vitro><Inflammasome><Inflammation><Inflammatory><Inflammatory Response><Investigation><Label><Laboratory Research><Link><Liquid substance><MT-bound tau><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Membrane><Mentors><Mentorship><Messenger RNA><Mice><Mice Mammals><Microglia><Molecular><Murine><Mus><Nerve Degeneration><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Odds Ratio><Oligo><Oligonucleotides><Pathway interactions><Phagocytes><Phagocytic Cell><Phase><Phenotype><Physiopathology><Postdoc><Postdoctoral Fellow><Predisposition><Primary Senile Degenerative Dementia><Process><Publishing><Relative Odds><Research><Research Associate><Risk Ratio><Role><Scanning><Series><Single Base Polymorphism><Single Nucleotide Polymorphism><Susceptibility><Task Forces><Tau forming aggregates><Tauopathies><Techniques><Testing><Therapeutic><Training><Universities><Work><Writing><abnormally aggregated tau protein><advisory team><aggregation in tau><alzheimer model><amebocyte><apo E-4><apo E4><apo epsilon4><apoE epsilon 4><apoE-4><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-4><apolipoprotein E4><attenuate><attenuates><biophysical foundation><biophysical principles><biophysical sciences><candidate validation><career><cell biology><compare to control><comparison control><cytokine><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><disease model><disease phenotype><disorder model><driving><exchange factor><experience><experiment><experimental research><experimental study><experiments><filamentous tau inclusion><flow cytophotometry><fluid><gitter cell><guanosinetriphosphatase><guanosinetriphosphatase activating protein><host response><immune system response><immunoresponse><in vivo><innate immune function><insoluble aggregate><interest><knock-down><knockdown><liability to disease><liquid><mRNA><membrane structure><mesoglia><microglial cell><microgliocyte><microtubule associated protein tau aggregation><microtubule associated protein tau deposit><microtubule bound tau><microtubule-bound tau><model of animal><mouse model><murine model><nerve cell death><nerve cell loss><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neurodegenerative illness><neuroinflammation><neuroinflammatory><neurological degeneration><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><neuropathologic><neuropathologic tau><neuropathological><neuropathological tau><neuropathology><novel><oligos><paired helical filament of tau><pathophysiology><pathway><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><perivascular glial cell><post-doc><post-doctoral><post-doctoral trainee><primary degenerative dementia><protein aggregate><protein aggregation><rab G-Proteins><rab GTP-Binding Proteins><rab GTPases><recruit><research associates><resilience><resilient><response><self-aggregate tau><senile dementia of the Alzheimer type><single nucleotide variant><skills><social role><tau><tau PHF><tau Proteins><tau accumulation><tau aggregate><tau aggregation><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau fibrillation><tau fibrillization><tau filament><tau inclusion><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neurofibrillary tangle><tau neuropathology><tau oligomer><tau paired helical filament><tau pathology><tau pathophysiology><tau polymerization><tau protein accumulation><tau protein aggregation><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tau-tau interaction><tauopathic neurodegenerative disorder><tauopathy><trafficking><transcriptomics><uptake><τ Proteins><τ aggregation>
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Danielle Tometich

UNIVERSITY OF SOUTH FLORIDA, TAMPA, FL

Exploratory lead · 16/100
Active award
$248,999
FY 2026

Project Title

Cancer-related cognitive impairment: Real-time evaluation and assessment of long-term impact of treatment on young adult survivors (CRCI REALITY)

Grant Number:

5R00CA270294-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2022

End Date:

12/31/2026

Project Abstract

Project Summary/Abstract Of over 80,000 adolescents and young adults (AYA) diagnosed with cancer in the United States each year, 85% live for at least five years after their cancer diagnosis. Adolescence and early young adulthood is a critical period for frontal neurodevelopment, and cancer treatmen...

Research Terms

<12-20 years old><18 year old><18 years of age><21+ years old><Acute><Address><Adherence><Adolescence><Adolescent><Adolescent Youth><Adolescent and Young Adult><Adolescent and young adult cancer patients><Adolescent and young adult cancer population><Adolescent and young adult oncology patients><Adolescent and young adults with cancer><Adult><Adult Human><Advisory Committees><Affect><Age><Amentia><Attention><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavior assessment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Brain Trauma><Brain region><Breast Cancer survivor><Cancer Center><Cancer Control><Cancer Control Science><Cancer Survivor><Cancer Treatment><Cancers><Case-Comparison Studies><Case-Compeer Studies><Case-Referent Studies><Case-Referrent Studies><Case/Control Studies><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Communities><Comprehensive Cancer Center><Conditioning Therapy><Controlled Environment><Cross-Sectional Studies><Cross-Sectional Survey><Data><Data Analyses><Data Analysis><Dementia><Depressed mood><Development><Development Plans><Diagnosis><Disease Frequency Surveys><Disturbance in cognition><Ecological momentary assessment><Education><Educational aspects><Evaluation><Executive Dysfunction><Executive Function Deficit><Executive Impairment><Exposure to><Fatigue><Future><Gender><Goals><Groups at risk><History><Immediate Memory><Impaired cognition><Informal Social Control><Intervention><Interview><Investigators><Jobs><Knowledge><Lack of Energy><Life><Literature><Long-Term Survivors><Low Prevalence><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Measures><Memory><Mentorship><Methodology><Methods><Neural Development><Neuropsychologic Tests><Neuropsychological Tests><Neuropsychologies><Neuropsychology><Occupational><Occupations><Participant><Patient Self-Report><People at risk><Persons at risk><Phase><Physical activity><Population><Populations at Risk><Position><Positioning Attribute><Predisposition><Prevalence><Problem Solving><Procedures><Professional Positions><Prospective Studies><Puberty><QOL><Qualifying><Quality of life><Recording of previous events><Reporting><Research><Research Personnel><Researchers><Risk Factors><Sampling><Schools><Self Regulation><Self-Report><Short-Term Memory><Sleep><Sleep disturbances><Stress><Survey Instrument><Surveys><Survivors><Susceptibility><Task Forces><Time><Training><Traumatic Brain Injury><United States><Vulnerable Populations><Work><Wrist><aberrant sleep><acceptability and feasibility><actigraph><actigraphy><adolescence (12-20)><adult youth><adulthood><advisory team><age 18><age 18 years><ages><anti-cancer therapy><artificial environment><behavior intervention><behavioral assessment><behavioral intervention><cancer among adolescent and young adults><cancer diagnosis><cancer related cognitive decline><cancer related cognitive dysfunction><cancer therapy><cancer-directed therapy><cancer-related cognitive impairment><career development><case-control survey><case-controlled studies><cognitive assessment><cognitive defects><cognitive dysfunction><cognitive function><cognitive loss><cognitive performance><cognitive testing><compare to control><comparison control><critical period><cross-sectional research study><data interpretation><depressed><design><designing><developmental><disrupted sleep><disturbed sleep><economic security><economic self-sufficiency><economic stability><economic well-being><eighteen year old><eighteen years of age><experience><financial security><financial stability><financial well-being><high school><histories><impaired sleep><improved><innovate><innovation><innovative><irregular sleep><juvenile><juvenile human><malignancy><malleable risk><mid life><mid-life><middle age><middle aged><midlife><modifiable risk><neoplasm/cancer><neurodevelopment><neuron toxicity><neuronal toxicity><neuropsychologic><neurotoxic><neurotoxicity><physical symptom><programs><prospective research study><prospective survey><psychological symptom><recruit><sadness><skill acquisition><skill development><sleep disruption><sleep dysregulation><sleep/wake disruption><sleep/wake disturbance><survivorship><traumatic brain damage><vulnerable group><vulnerable individual><vulnerable people><working memory><young adult><young adult age><young adulthood>
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Hamlet Gasoyan

CLEVELAND CLINIC LERNER COM-CWRU, CLEVELAND, OH

Exploratory lead · 16/100
Active award
$248,999
FY 2026

Project Title

Modifiable Determinants of Disparities in Multiple Myeloma Treatment Patterns

Grant Number:

5R00CA277136-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT In this K99/R00 Pathway to Independence Award for Outstanding Early-Stage Postdoctoral Researchers application, Dr. Hamlet Gasoyan outlines a detailed proposal to enhance his research training in cancer disparities research in tandem with examining the modifiable determinant...

Research Terms

<21+ years old><Adult><Adult Human><American><Area><Award><Biology><Black Populations><Black group><Black individual><Black people><Blacks><Bortezomib><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 pandemic affected><COVID-19 pandemic consequence><COVID-19 pandemic effects><COVID-19 pandemic impact><COVID-19 pandemic impacted><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Cancer Center><Caring><Cessation of life><Clinical><Communities><Complex><Cost Sharing><Data><Data Bases><Databases><Death><Death Rate><Deductibles><Dexamethasone><Diagnosis><Disparities><Disparity><Drug Prescribing><Drug Prescriptions><Drugs><Electronic Health Record><Exposure to><Genetic><Goals><Health><Health Care><Health Insurance><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Health Policy><Health Services Evaluation><Health Services Research><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><IMiD3 cpd><Incidence><Individual><Induction Therapy><Inpatients><Insurance><Insurance Coverage><Insurance Status><Investigators><Jewish><Jews><Knowledge><Lead><Maintenance Therapy><Malignant Hematologic Neoplasm><Medicaid><Medical><Medical Care Research><Medicare><Medication><Mentors><Multiple Myeloma><NEOADJ><Neoadjuvant><Neoadjuvant Therapy><Neoadjuvant Treatment><Newly Diagnosed><Obesity><Obesity associated cancer><Obesity related cancer><Oral><Out-of-Pocket Expense><Out-patients><Outcome><Outpatients><Pathway interactions><Patients><Patterns of Care><Pb element><Persons><Pharmaceutical Preparations><Phase><Plasma-Cell Myeloma><Policy Maker><Postdoc><Postdoctoral Fellow><Productivity><Progenitor Cell Transplantation><Race><Races><Racial Group><Regimen><Research><Research Associate><Research Personnel><Research Training><Researchers><Retrospective cohort><Risk Factors><Role><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Stem Cell Transplantation><Stem cell transplant><Time><Title 18><Training><Treatment Cost><Treatment Protocols><Treatment Regimen><Treatment Schedule><Triplet Multiple Birth><Triplets><Uncovered Medical Expenses><Uncovered Uninsured Medical Expense><Underserved Population><Uninsured Medical Expense><Urbanicity><access disparities><accessibility disparities><adiposity><adulthood><black patient><cancer disparity><cancer health disparity><cancer location><cancer site><cancer-related health disparity><care costs><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 pandemic consequence><coronavirus disease 2019 pandemic impact><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><corpulence><cost><data base><deprivation><disparate effect><disparate impact><disparate result><disparities in access><disparities in race><disparity due to race><disparity in cancer><drug/agent><effects following the COVID-19 pandemic><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><experience><health care policy><health data><health insurance for disabled><health insurance plan><health plan><health plans><heavy metal Pb><heavy metal lead><impact of the SARS-CoV-2 pandemic><indexing><induction therapies><inequality due to race><inequality in access><inequitable effect><inequitable impact><inequitable outcome><inequity due to race><inequity in access><inequity in accessibility><lenalidomide><medical expenses not covered by insurance><medication prescription><member><mortality><mortality rate><myeloma><myelomatosis><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><out-of-pocket costs><out-of-pocket health care costs><outcome disparities><outcome inequality><outcome inequity><pandemic><pandemic disease><pathway><peer><post-doc><post-doctoral><post-doctoral trainee><pre-pandemic><prescribed medication><progenitor transplantation><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial origin><racial population><racial subgroup><racially unequal><research associates><residence><residential building><residential site><services research><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><skills><social><social health determinants><social role><stem and progenitor cell transplantations><total medical expenditure><treatment pattern><under served community><under served group><under served individual><under served people><under served population><underserved community><underserved group><underserved individual><underserved people><unequal effect><unequal impact><unequal outcome>
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Natalie Del Vecchio

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 16/100
Active award
$248,999
FY 2026

Project Title

Assessing how multilevel factors shape disparities in cancer screening

Grant Number:

4R00CA277552-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

11/30/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT Cancer screening is an essential cancer control strategy for several cancer types, including colorectal, cervical, and lung cancer screening. However, cancer screening utilization rates are suboptimal and disparities by race and ethnicity persist. Observed disparities in cer...

Research Terms

<Adherence><Affect><Attitude><Award><Belief><Breast Cancer Detection><Breast cancer screening><Breast screening><CRC screening><CT Lung Screening><Cancer Cause><Cancer Control><Cancer Control Science><Cancer Death Rates><Cancer Etiology><Cancers><Caring><Cervical Cancer><Cervical Cancer Screening><Cervix Cancer><Cessation of life><Clinical Trials><Colorectal Cancer><Community Health Care><Data><Death><Development><Development Plans><Disparities><Disparity><Dose><Ensure><Ethnic Origin><Ethnicity><Goals><Health Care Rationing><Health Care Systems><Health Disparities Research><Health disparities related research><Health system><Incentives><Incidence><Integrated Health Care Systems><Intervention><Interview><Investigators><Knowledge acquisition><Lung><Lung CAT Scan><Lung CT><Lung CT scan><Lung Respiratory System><Malignant Cervical Neoplasm><Malignant Cervical Tumor><Malignant Neoplasm of the Cervix><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Cervix><Malignant Tumor of the Cervix Uteri><Malignant Tumor of the Lung><Malignant Uterine Cervix Neoplasm><Malignant Uterine Cervix Tumor><Malignant neoplasm of cervix uteri><Malignant neoplasm of lung><Mentorship><NCI Organization><National Cancer Institute><Outcome><Patients><Policies><Population><Population Heterogeneity><Population Research><Population-based research><Population-level research><Process><Provider><Pulmonary Cancer><Pulmonary malignant Neoplasm><Qualitative Evaluations><Race><Races><Recommendation><Regulation><Research><Research Methodology><Research Methods><Research Personnel><Researchers><Sampling><Screening for cancer><Shapes><Structure><Survey Instrument><Surveys><Testing><Theoretic Models><Theoretical model><Training><Underserved Population><Uterine Cervix Cancer><Work><cancer care><cancer disparity><cancer health disparity><cancer mortality rate><cancer prevention><cancer related death rate><cancer related mortality rate><cancer specific mortality rate><cancer survival><cancer type><cancer-related health disparity><career><career development><cervical cancer early detection><cervical screening><clinical decision support><clinician factors><clinician-level factors><colorectal cancer detection><colorectal cancer early detection><colorectal cancer screening><community care><computerized tomography lung screening><detect colorectal cancer><developmental><disparate effect><disparate impact><disparate result><disparities in mortality><disparities in race><disparity due to race><disparity in cancer><disparity in ethnic><disparity in health><diverse populations><early cancer detection><ethnic based disparity><ethnic disadvantage><ethnic disparity><ethnic diversity><ethnic inequality><ethnic inequity><ethnically diverse><ethnicity disparity><experience><health and care delivery><health care delivery><health delivery systems><health disparities science><health disparity><health services delivery><heterogeneous population><implementation science><improved><improved outcome><inequality due to race><inequitable effect><inequitable impact><inequitable outcome><inequity due to race><integrated health system><integrated system of care><investigate population><lung cancer><lung cancer early detection><lung cancer screening><lung computerized axial tomography scan><lung computerized tomography><lung computerized tomography scan><malignancy><mammary cancer detection><mammary screening><methods to study multiple-level influences><mortality><mortality disparity><multi-level analysis><multi-level model><multilevel analysis><multilevel model><multilevel modeling><neoplasm/cancer><outcome disparities><outcome inequality><outcome inequity><physician factors><physician-level factors><population diversity><population investigation><population level investigation><population specific research><precancer cervical detection><primary care provider><programs><provider factors><provider-level factors><providers from primary care><providers of primary care><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial diversity><racial inequality><racial inequity><racial origin><racially diverse><racially unequal><research and methods><screening><screening cancer patients><screening policy><screening program><screenings><skills><studies of populations><study of the population><study population><success><support tools><survey population><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people><unequal effect><unequal impact><unequal outcome><uptake>
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Hojong Yoon

UNIVERSITY OF TX MD ANDERSON CAN CTR, HOUSTON, TX

Exploratory lead · 16/100
Active award
$248,999
FY 2026

Project Title

A Chemoproteomic Approach to Identify Molecular Glues for Targeted Cancer Therapy

Grant Number:

5R00CA287069-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2028

Project Abstract

Project Summary / Abstract Research Plan: Targeted protein degradation using molecular glues - small molecules that bring a protein of interest in proximity to an E3 ligase - emerged as a promising therapeutic strategy for cancer, especially for proteins that have been historically challenging to ta...

Research Terms

<AML - Acute Myeloid Leukemia><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Address><Anti-Cancer Agents><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Area><Assay><B cell lymphoma 6><B-Cell CLL/Lymphoma-6 Gene><BCL5><BCL6><BCL6 gene><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Biochemical><Biological><Biological Assay><Biology><CRISPR activation><CRISPR activator><CRISPR based activation><CRISPR gene activation><CRISPR transcription activation><CRISPR transcriptional activation><CRISPR-Cas-9-mediated gene activation><CRISPR-based gene activation><CRISPR-dCAS9 Activator><CRISPR-mediated transcriptional activation><CRISPR/CAS9 activation><CRISPR/CAS9 gene activation><CRISPR/dCas9 activation><CRISPR/dCas9-based transcriptional activation><CRISPRa><Cancer Biology><Cancer Drug><Cancers><Chemicals><Clinic><Clinical><Clinical Trials><Complex><Comprehension><Cys-His2 Zinc Finger Transcription Factor Gene><Data><Data Analyses><Data Analysis><Development><Development Plans><Drug resistance><Drugs><E3 Ligase><E3 Ubiquitin Ligase><Energy Transfer><FDA approved><Fluorescence><General Transcription Factor Gene><General Transcription Factors><Glues><Goals><Human><IMiD3 cpd><Influentials><Institution><Investigation><Investigational Drugs><Investigational New Drugs><Investigators><LAZ-3 Gene><LAZ3><Lead><Libraries><Malignant Neoplasms><Malignant Tumor><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Medication><Medicinal Chemistry><Mentors><Metabolic Protein Degradation><Methodology><Methods><Modality><Modern Man><Molecular><Multiple Myeloma><Nature><Neoplastic Disease Chemotherapeutic Agents><Oncogenic><Outcome><Pathway interactions><Pb element><Pharmaceutic Chemistry><Pharmaceutical Chemistry><Pharmaceutical Preparations><Pharmacology><Phase><Phenotype><Plasma-Cell Myeloma><Play><Polymers><Polyubiquitination><Position><Positioning Attribute><Process><Program Development><Protein Degradation Induction><Protein Turnover><Proteins><Proteome><RNA Splicing><Receptor Protein><Regulatory Protein Degradation><Reporter><Reporting><Research><Research Personnel><Researchers><Resistance><Role><Splicing><System><Testing><Therapeutic><Time><Training><Training Programs><Transcription Factor Proto-Oncogene><Transcription factor genes><Tumor-Specific Treatment Agents><Ubiquitilation><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitination><Ubiquitinoylation><Work><ZNF51><ZNF51 Gene><Zinc Finger Protein 51 Gene><activating CRISPR technology><acute granulocytic leukemia><acute myeloid leukemia><anti-cancer><anti-cancer drug><biologic><career development><chemoproteomics><data interpretation><data visualization><developmental><drug discovery><drug efficacy><drug resistant><drug/agent><heavy metal Pb><heavy metal lead><improved><innovate><innovation><innovative><insight><interest><lenalidomide><malignancy><multidrug use><multiple drug use><myeloma><myelomatosis><neoplasm/cancer><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><pharmacologic><poly drug use><polydrug use><polymer><polymeric><polymerization><pre-clinical><preclinical><programs><protein degradation><protein protein interaction><receptor><recruit><resistance to Drug><resistant><resistant to Drug><screening><screenings><skills><small molecule><social role><success><targeted cancer therapy><transcription factor><ubiquination><ubiquitin conjugation><ubiquitin-protein ligase>
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Renske Lok

UNIVERSITY OF COLORADO, Boulder, CO

Exploratory lead · 16/100
Active award
$248,999
FY 2026

Project Title

Application of precision medicine to phototherapy: a stepped care approach to consolidate sleep and slow cognitive decline in older adults

Grant Number:

4R00AG084846-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/9/2024

End Date:

12/31/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT While consolidated sleep is crucial for healthy cognition and mood in older individuals, many suffer from sleep- wake fragmentation, a risk factor for developing Alzheimer's disease. One countermeasure of sleep-wake fragmentation is exposure to bright light ("phototherapy")....

Research Terms

<AD dementia><AD risk><AD risk factor><AI system><APOE e4><APOE-ε4><APOEε4><Accelerometer><Actinotherapy><Address><Adverse effects><Age><Aging><Algorithms><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease risk><Alzheimers Dementia><Anxiety><Artificial Intelligence><Behavioral Sciences><Big Data><Big Data Analytics><Big Data Methods><Big Data Tools><BigData><Blood><Blood Reticuloendothelial System><Caring><Causality><Cause of Death><Chronobiology><Clinical Trials><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Computer Reasoning><Data><Data Set><Decision Making><Deterioration><Development><Development Plans><Disturbance in cognition><Effectiveness><Ensure><Environment><Etiology><Exposure to><Fracture due to osteoporosis><Genotype><Gerontology><Goals><Grant><Health><Hour><Human><Impaired cognition><Individual><Institutionalization><Interdisciplinary Research><Interdisciplinary Study><International><Interruption><Intervention><Intervention Studies><Investigators><Knowledge><Lasso><Learning><Learning Skill><Light><Light Therapy><Literature><Long-Term Effects><Machine Intelligence><Machine Learning><Math Models><Measures><Medical><Mental Depression><Mental Health><Mental Hygiene><Mentors><Modeling><Modern Man><Moods><Multidisciplinary Collaboration><Multidisciplinary Research><Neuropsychologies><Neuropsychology><Older Population><Onset of illness><Osteoporosis with fracture><Osteoporotic fracture><Outcome><Output><Participant><Patients><Pattern><Personal Satisfaction><Persons><Phase><Photoradiation><Photoradiation Therapy><Phototherapy><Physicians><Physiologic><Physiological><Population><Primary Senile Degenerative Dementia><Productivity><Psychiatry><Psychological Health><Publishing><QOL improvement><Questionnaires><Reporting><Research><Research Personnel><Research Resources><Research Support><Research Training><Researchers><Resources><Risk Factors><Secondary to><Sleep><Sleep Disorders><Sleep Fragmentations><Sleep Wake Cycle><Solid><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Techniques><Testing><Therapeutic Intervention><Time><Training><United States><Universities><Woman><Writing><accelerometry><activity monitor><activity tracker><ages><alzheimer risk><apo E-4><apo E4><apo epsilon4><apoE epsilon 4><apoE-4><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-4><apolipoprotein E4><assess effectiveness><career><career development><causation><circadian><circadian clock><circadian pacemaker><cognitive assessment><cognitive dysfunction><cognitive function><cognitive loss><cognitive testing><data modeling><deep learning based neural network><deep learning neural network><deep neural net><deep neural network><depression><design><designing><determine effectiveness><developmental><disease causation><disease onset><disorder onset><effectiveness assessment><effectiveness evaluation><empowerment><evaluate effectiveness><examine effectiveness><expectation><exposure to light><exposure to visible light><flexibility><flexible><gerontologic><improved><improvement on sleep><improvements in QOL><improvements in quality of life><intervention design><intervention research><intervention therapy><interventional research><interventional study><interventions research><light exposure><light intervention><light pollution exposure><light treatment><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><mathematic model><mathematical model><mathematical modeling><men><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><model of data><model the data><modeling of the data><neurocognitive test><neuropsychologic><novel><older adult><older adulthood><older groups><older individuals><older person><osteoporosis associated fracture><osteoporosis related fracture><osteoporosis with pathological fracture><precision medicine><precision-based medicine><prevent><preventing><primary degenerative dementia><prodromal AD><prodromal Alzheimer's><prodromal Alzheimer's disease><quality of life improvement><random forest><research data dissemination><research dissemination><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><skill acquisition><skill development><skills><sleep diseases><sleep dysfunction><sleep illness><sleep improvement><sleep pattern><sleep problem><sleep routine><sleep schedule><sleep to wake transition><sleep to wakefulness transition><sleep wakefulness cycle><sleep/wake patterns><sleep/wake transitions><social determinants><sociodeterminant><standard of care><statistical analysis><therapy design><tool><treatment design><well-being><wellbeing>
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Juan Hu

SAN DIEGO STATE UNIVERSITY, SAN DIEGO, CA

Exploratory lead · 16/100
Active award
$248,998
FY 2026

Project Title

Pharmacokinetics-Based DNA-Encoded Library Screening

Grant Number:

5R00GM149941-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

11/30/2027

Project Abstract

PROJECT ABSTRACT This R00 proposal seeks to expand the space of druggable protein targets through the development of novel analytical technology that will guide the design of next-generation, non-Lipinski molecular therapeutics and diagnostics. Cyclic peptides, which are not drug-like (i.e., Lipin...

Research Terms

<2019 novel corona virus><2019 novel coronavirus><2019-nCoV><3-D><3-Dimensional><3D><Address><Alkynes><Amino Acids><Antiproteases><Area><Artificial Membranes><Assay><Azides><Binding><Bioassay><Biological Assay><Biology><COVID-19 virus><COVID19 virus><Carboxylic Acids><Career Mobility><Cell Body><Cell Membrane Permeability><Cells><Cellular Assay><Chemicals><Chemistry><Classification><Clinic><CoV-2><CoV2><Communities><Complex><Coupled><Cyclic Peptides><Cysteine><DNA><Data><Data Set><Deoxyribonucleic Acid><Descriptor><Deubiquitination><Development><Diagnostic><Dimensions><Drug Kinetics><Drugs><Endopeptidase Inhibitors><Environment><Esteroproteases><Evaluation><Exhibits><Fostering><Funding><Future><Generalized Growth><Generations><Goals><Growth><H-bond><Half-Cystine><Hand><High Throughput Assay><Hydrogen Bonding><Hydrogen Oxide><Immune system><In Vitro><L-Cysteine><L-Proline><Libraries><Ligands><Lipids><Liposomal><Liposomes><Machine Learning><Measurement><Medication><Membrane><Microfluidics><Modality><Modeling><Molecular><Molecular Configuration><Molecular Conformation><Molecular Dynamics Simulation><Molecular Interaction><Molecular Stereochemistry><Oral Administration><Oral Drug Administration><Papain><Penetration><Peptidase Inhibitors><Peptidases><Peptide Hydrolase Inhibitors><Peptide Hydrolases><Peptide Peptidohydrolase Inhibitors><Peptides><Permeability><Pharmaceutical Preparations><Pharmacokinetics><Phase><Play><Position><Positioning Attribute><Proline><Property><Protease Antagonists><Protease Gene><Protease Inhibitor><Proteases><Proteinase Inhibitors><Proteinases><Proteins><Proteolytic Enzymes><Radial><Radius><Reaction><Research><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Screening Result><Sedalis><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Solvents><Sorting><Structure><Structure-Activity Relationship><Surface><Systematics><Techniques><Technology><Thalidomide><Therapeutic><Tissue Growth><Training><Universities><Virus Replication><Water><Wuhan coronavirus><aminoacid><assay development><career advancement><career development><career transition><cell assay><chemical library><chemical structure function><combinatorial><conformation><conformational><conformational state><conformationally><conformations><conformer><coronavirus disease 2019 virus><coronavirus disease-19 virus><design><designing><developmental><dimension reduction><dimensionality reduction><drug candidate><drug/agent><hCoV19><hands><high throughput screening><high throughput technology><inhibitor><intraoral drug delivery><machine based learning><machine learning based model><machine learning model><member><membrane permeability><membrane structure><miniaturize><miniaturized><molecular dynamics><molecular mass><nCoV2><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ontogeny><pre-clinical><preclinical><professor><programs><protein protein interaction><reduce data dimension><reduce dimensionality><screening><screenings><skills><small molecule><small molecule libraries><social role><structure function relationship><success><three dimensional><tool><tool development><viral multiplication><viral replication><virus multiplication><µfluidic>
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Brittany Nicole Kuhn

BAYLOR UNIVERSITY, WACO, TX

Exploratory lead · 16/100
Active award
$248,975
FY 2026

Project Title

Neurobiological mechanisms underlying resiliency and vulnerability to opioid use disorder

Grant Number:

4R00DA057390-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2023

End Date:

11/30/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT There has been a significant rise in opioid use disorder (OUD) in the United States over the past decade, making it imperative to gain a better understanding of the behavioral characteristics underlying OUD vulnerability. Current rodent models focus on how one or few traits ...

Research Terms

<Affect><Attenuated><Behavior><Behavioral><Behavioral Model><CNS plasticity><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Characteristics><Cluster Analyses><Cluster Analysis><Common Rat Strains><Complex><Confocal Microscopy><Cues><Dendrites><Dendritic Spines><Development><Diacetylmorphine><Diameter><Diamorphine><Disease><Disorder><Drug Regulations><Electrophysiology><Electrophysiology (science)><FBJ Murine Osteosarcoma Viral Oncogene Homolog><FOS Family Protein><FOS Protein><Female><Genetic><Globus Pallidus><Habenula><Head><Heroin><Heterogeneity><Human><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Individual><Intracellular Communication and Signaling><Label><Lateral><Link><Measures><Mediating><Modeling><Modern Man><Morphology><N Methyl D aspartic Acid><N methyl D aspartate><N-Methyl-D-aspartate><N-Methylaspartate><NMDA><Nerve Cells><Nerve Unit><Network-based><Neural Cell><Neurobiology><Neurocyte><Neuronal Plasticity><Neurons><Neurophysiology / Electrophysiology><Nucleus Accumbens><Nucleus Subthalamicus><Output><Pathway interactions><Phase><Phenotype><Population><Prediction of Response to Therapy><Process><Rat><Rats Mammals><Rattus><Regulation><Relapse><Reporter><Rewards><Rodent Model><Signal Transduction><Signal Transduction Systems><Signaling><Spinal Column><Spine><Structure><Structure of subthalamic nucleus><Substance Use Disorder><Subthalamic Nucleus><Symptoms><Synaptic Potentials><Techniques><Testing><Tracer><Training><Treatment Efficacy><United States><Vertebral column><Viral><Work><addiction><addictive disorder><attenuate><attenuates><backbone><behavior phenotype><behavioral phenotyping><biological signal transduction><build resilience><build resiliency><c-fos Protein><career><central nervous system plasticity><dendrite spine><density><develop resilience><develop resiliency><developmental><drug seeking behavior><electrophysiological><enhance resilience><enhance resiliency><experiment><experimental research><experimental study><experiments><facilitate resilience><functional plasticity><genetic approach><genetic strategy><genetic technology><heroin intake><heroin use><human model><improve resilience><improve resiliency><increase resilience><increase resiliency><individual heterogeneity><individual variability><individual variation><insight><intervention efficacy><male><model of human><network models><neural circuit><neural circuitry><neural plasticity><neurobiological><neurobiological mechanism><neurocircuitry><neuronal><neuroplastic><neuroplasticity><novel><opiate use disorder><opioid use disorder><optogenetics><pallidum><patch clamp><pathway><postsynaptic><predict therapeutic response><predict therapy response><promote resilience><promote resiliency><protein biomarkers><protein markers><resilience><resilience development><resilient><response><substance use and disorder><synaptic circuit><synaptic circuitry><therapeutic efficacy><therapy efficacy><therapy prediction><trait><treatment prediction><treatment response prediction><♀><♂>
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Tengteng Wang

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Exploratory lead · 16/100
Active award
$248,930
FY 2026

Project Title

Identifying the role of the gut microbiome in the etiology of benign breast disease

Grant Number:

5R00CA267557-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT The overall goal of this project is to identify the role of the gut microbiome in the etiology of benign breast disease (BBD), and thereby shed light on its pathogenesis in relation to breast cancer. Approximately one out of every five women in the United States has been dia...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Age><Age at Menarche><Applications Grants><Attention><Autoregulation><Award><Bacteria><Bacteroides><Benign><Bioinformatics><Biopsy><Breast><Breast Cancer><Breast Cancer Epidemiology><Breast Cancer Prevention><Breast Diseases><Breast Disorder><Breast biopsy><Cancer Cause><Cancer Etiology><Catalogs><Causality><Classification><Collaborations><Collection><Data><Data Analyses><Data Analysis><Data Set><Development><Diagnosis><Endocrine Gland Secretion><Environment><Estrogens><Etiology><Event><Exogenous Hormone Therapy><Exogenous Hormone Use><Feces><First Births><Fostering><Functional Metagenomics><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><General Taxonomy><Goals><Grant Proposals><High Risk Woman><Homeostasis><Hormonal><Hormonal Risk Factor><Hormones><Hospitals><Human Microbiome><Intermediary Metabolism><Investigators><Knowledge><Lesion><Link><Liquid Chromatography><Malignant Breast Neoplasm><Measurement><Mediating><Mentors><Metabolic Processes><Metabolism><Metagenomics><Methods><Microbiomics><Morbidity><Multiomic Data><Nested Case-Control Study><Nulliparas><Nulliparity><Nulliparous><Nurses><Nurses' Health Study><Oral Contraceptives><Participant><Pathogenesis><Pathologic><Pathologist><Pathology><Pathway interactions><Physiological Homeostasis><Play><Predicting Risk><Productivity><Proliferative Breast Disease><Proliferative Breast Lesion><Proliferative Fibrocystic Change><Proliferative Type Breast Fibrocystic Change><Prospective Studies><Reporting><Reproductive Factors><Reproductive History><Reproductive History Epidemiology><Reproductive Issues><Research><Research Personnel><Researchers><Retrospective Studies><Risk><Risk Factors><Risk Reduction><Role><Sample Size><Shotguns><Strategic vision><Systematics><Taxonomy><Testing><Therapeutic Estrogen><Therapeutic Hormone><Tissue Sample><Training><United States><Variant><Variation><Woman><Women's mortality><Women's study><ages><at-risk females><at-risk women><benign proliferative breast disease><biomedical scientist><birth control pill><breast pathology><career><catalog><causation><cohort><community microbes><data interpretation><death among females><death among women><death in females><death in women><developmental><digestive tract microbiome><disease causation><disease diagnosis><disease epidemiology><disease risk><disease subgroups><disease subtype><disorder risk><disorder subtype><enteric microbial community><enteric microbiome><enteric microbiota><experience><fecal microbiome><fecal sample><female death><female mortality><female study><females at high risk><forecasting risk><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><high risk><high risk females><human-associated microbiome><innovate><innovation><innovative><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><malignant breast tumor><mammary cancer prevention><mammary disorder><mammary tumor prevention><menopausal hormone therapy><menopausal hormone treatment><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><metagenome sequencing><metagenomic sequencing><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial signature><microbiome><microbiome community composition><microbiome composition><microbiome intervention><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microbiota derived metabolites><microbiota metabolites><microflora><microorganism community><mortality><mortality among females><mortality among women><mortality in females><mortality in women><multidisciplinary><multiomics><multiple omic data><multiple omics><multispecies consortia><novel><nurse><panomics><pathway><polymicrobial community><precancer><precancerous><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predicts risk><premalignant><prevent breast cancer><programs><prospective><prospective research study><prospective survey><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><reproductive><retrospective research study><retrospective survey><risk prediction><risk predictions><risk-reducing><sample collection><shot gun><small molecule><social role><specimen collection><stool><stool microbiome><stool sample><stool specimen><stool-associated microbiome><study among females><study among women><study in females><study in women><study on females><study on women><study within women><tandem mass spectrometry><women at high risk><women's death>
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Danielle A. Wallace

EMORY UNIVERSITY, ATLANTA, GA

Exploratory lead · 16/100
Active award
$248,705
FY 2026

Project Title

Investigating relationships between naturalistic light exposure and sleep

Grant Number:

4R00HL166700-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/2/2026

End Date:

1/31/2029

Project Abstract

PROJECT SUMMARY Sleep irregularity is highly prevalent and linked to downstream adverse cardiometabolic health outcomes, but the upstream drivers of sleep irregularity are not well characterized. Adverse health outcomes associated with irregular sleep timing mirror those linked to shift work, and...

Research Terms

<Address><Affect><Age><Area><Award><Behavior><Biological><Biological Markers><Body Temperature><Cardiac Chronotropism><Chronobiology><Circadian desynchrony><Clinical><Cohort Studies><Communities><Cues><DNA Methylation><DNA mutation><Data><Data Analyses><Data Analysis><Data Collection><Development><Development Plans><Dimensions><Disease><Disorder><Drowsiness><Environment><Environmental Exposure><Environmental Factor><Environmental Health><Environmental Health Science><Environmental Risk Factor><Epidemiology><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Foundations><General Population><General Public><Genetic Change><Genetic Materials><Genetic defect><Genetic mutation><Goals><Grant><HCHS/SOL Study><HCHS/SOL cohort><Health><Health Promotion><Health Status><Heart Rate><Hispanic Community Health Study/Study of Latinos><History><Humidity><Interdisciplinary Research><Interdisciplinary Study><Intervention><Investigators><Knowledge><Level of Health><Light><Linear Models><Link><Measurement><Measures><Mentors><Modeling><Molecular Epidemiology><Multi-Ethnic Study of Atherosclerosis><Multidisciplinary Collaboration><Multidisciplinary Research><Mutation><NIH><National Institutes of Health><Noise><Non-linear Models><Nonlinear Models><Outcome><Participant><Pathway interactions><Patient Recruitments><Pattern><Phase><Photoradiation><Population><Printing><Probabilistic Models><Probability Models><Prospective cohort><Proxy><Public Health><Recording of previous events><Reporting><Research><Research Personnel><Researchers><Role><Salutogenesis><Site><Sleep><Sleep Deprivation><Sleep disturbances><Somnolence><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Statistical Models><Sum><System><Temperature><Training><United States National Institutes of Health><Vision research><Work><aberrant sleep><actigraph><actigraphy><ages><bio-markers><biologic><biologic marker><biomarker><blood-based biomarker><blood-based marker><candidate identification><cardiometabolic><cardiometabolism><career><career development><circadian><circadian desynchronization><circadian misalignment><cohort><cohort research study><cohort survey><community setting><data interpretation><day shift><deficient sleep><developmental><disease prevention><disorder prevention><disrupted sleep><disturbed sleep><environmental risk><epidemiologic><epidemiological><epigenetically><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><exposure to light><exposure to visible light><genome mutation><genome scale><genome-wide><genomewide><health level><high dimensionality><histories><impaired sleep><improvement on sleep><inadequate sleep><insufficient sleep><irregular sleep><light exposure><light pollution exposure><methylation biomarker><methylation marker><methylation pattern><molecular biomarker><molecular marker><multi-ethnic><multiethnic><night shift><night work><novel><participant recruitment><pathway><population health><programs><promoting health><prospective><public health intervention><secondary analysis><sex><shift work><shiftwork><sleep amount><sleep debt><sleep deficiency><sleep deficit><sleep disruption><sleep duration><sleep dysregulation><sleep episode><sleep health><sleep hygiene><sleep improvement><sleep insufficiency><sleep interval><sleep length><sleep loss><sleep period><sleep quantity><sleep time><sleep wellness><sleep/wake disruption><sleep/wake disturbance><sleepiness><social role><statistical analysis><statistical linear mixed models><statistical linear models><successful intervention><time asleep><time during sleep><time in sleep><time spent asleep><time spent sleeping><tool>
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Dheeraj Roy

STATE UNIVERSITY OF NEW YORK AT BUFFALO, AMHERST, NY

Exploratory lead · 16/100
Active award
$248,469
FY 2026

Project Title

Determining the Role of Distinct Parafascicular Thalamic Circuits in Motor Behaviors Relevant to Parkinson’s Disease

Grant Number:

5R00NS125131-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2021

End Date:

11/30/2026

Project Abstract

Project Summary The ability to move from one place to another and acquire different motor skills is critical for our survival. Many human disorders including Parkinson's disease, Huntington's disease, and Tourette syndrome, cause abnormal motor behaviors. Identifying neural circuits that mediate loc...

Research Terms

<Acceleration><Assay><Basal Ganglia><Basal Nuclei><Basic Research><Basic Science><Behavior><Behavioral><Bioassay><Biological Assay><Brain region><Calcium><Common Rat Strains><Complex><Corpus Striatum><Corpus striatum structure><Data><Deep Brain Stimulation><Defect><Degenerative Neurologic Disorders><Development Plans><Development and Research><Disease><Disorder><Dorsal><Dysfunction><Dyskinesia Syndromes><Electrophysiology><Electrophysiology (science)><Exhibits><Functional disorder><Future><Genetic><Gilles de la Tourette syndrome><Gilles de la Tourette's Disease><Globus Pallidus><Guinon's disease><Heterogeneity><Human><Huntington Chorea><Huntington Disease><Huntington's><Huntington's Disease><Huntingtons Disease><Image><In vivo two-photon calcium imaging><Investigators><Life><Locomotion><Mediating><Mentors><Mice><Mice Mammals><Modern Man><Molecular Target><Motor><Motor Cortex><Motor Skills><Movement><Movement Disorder Syndromes><Movement Disorders><Murine><Mus><Muscarinic Acetylcholine Receptor><Muscarinic Receptors><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurons><Neurophysiology / Electrophysiology><Nucleus Subthalamicus><Paralysis Agitans><Parkinson><Parkinson Disease><Pathway interactions><Pattern><Phase><Phenotype><Physiopathology><Play><Primary Parkinsonism><Process><R & D><R&D><Rat><Rats Mammals><Rattus><Receptor Activation><Reporting><Research><Research Personnel><Researchers><Reversal Learning><Role><Striate Body><Striatum><Structure of subthalamic nucleus><Substantia Nigra><Substantia nigra structure><Subthalamic Nucleus><System><Testing><Thalamic Nuclei><Thalamic structure><Thalamus><Therapeutic><Tic Disorder, Combined Vocal and Multiple Motor><Tourette Syndrome><Tourette's><Tourette's Disease><Tourette's Disorder><Tourette's Syndrome><Wild Type Mouse><body movement><career development><debilitating symptom><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><disease model><disorder model><electrophysiological><experiment><experimental research><experimental study><experiments><frontal cortex><frontal lobe><imaging><in vivo><in vivo calcium imaging><innovate><innovation><innovative><learned behavior><learning behavior><locomotor learning><maladie des tics><motor ability><motor behavior><motor deficit><motor disease><motor disorder><motor dysfunction><motor impairment><motor learning><motor symptom><mouse model><movement impairment><movement limitation><murine model><neural><neural circuit><neural circuitry><neurocircuitry><neurodegenerative illness><neuronal><optogenetics><pallidum><pathophysiology><pathway><programs><putamen><research and development><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skill acquisition><skill development><social role><striatal><synaptic circuit><synaptic circuitry><thalamic><tic de Guinon><tool><wildtype mouse>
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Chen Cao

UNIVERSITY OF TEXAS DALLAS, RICHARDSON, TX

Exploratory lead · 16/100
Active award
$248,444
FY 2026

Project Title

Decoding the dynamics and regulation of parental allelic expression at single-cell resolution

Grant Number:

5R00HD102584-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

Project Abstract

Project Summary The inheritance of both the maternal and paternal genes is required for normal development to proceed. Yet, we are not equal products of both parents’ genes. With exclusive expression of specific genes from only one parent, allelic effects have been suggested to influence genetic arc...

Research Terms

<3-D><3-Dimensional><3D><4-dimensional><Alleles><Allelic Imbalance><Allelomorphs><Animals><Assay><Bar Codes><Bioassay><Biological Assay><Body Tissues><Causality><Cell Body><Cell Count><Cell Lineage><Cell Number><Cells><Characteristics><Chromatin><Ciona intestinalis><Complex><DNA Sequence><Data><Development><Development Plans><Developmental Process><Dimensions><Disease><Disorder><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Etiology><Four-dimensional><Frog><GWA study><GWAS><Gene Expression><Gene Transcription><Genes><Genetic><Genetic Diseases><Genetic Transcription><Genome><Genomics><Haplotypes><Human><Hybrids><Individual><Interdisciplinary Research><Interdisciplinary Study><Kinetics><Lineage Tracing><Link><Maps><Measures><Mentorship><Methods><Modern Man><Morphogenesis><Multidisciplinary Collaboration><Multidisciplinary Research><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Organ><Organism><Parents><Pattern><Phase><Population><Position><Positioning Attribute><Process><RNA Expression><Rana><Regulation><Resolution><Role><Single Base Polymorphism><Single Nucleotide Polymorphism><Single cell seq><Source><Specific qualifier value><Specified><Swimming><System><Tadpoles><Techniques><Technology><Time><Tissues><Training><Transcription><Variant><Variation><Vertebrate Animals><Vertebrates><Work><ascidian><barcode><career development><causation><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular lineage mapping><cellular lineage tracking><developmental><disease causation><disease risk><disorder risk><experiment><experimental research><experimental study><experiments><genetic architecture><genetic condition><genetic disorder><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><global gene expression><global transcription profile><innovate><innovation><innovative><living system><microscope imaging><microscopic imaging><microscopy imaging><morphogenetic process><neuronal><new approaches><novel approaches><novel strategies><novel strategy><parent><programs><resolutions><scATAC sequencing><scATAC-seq><scRNA sequencing><scRNA-seq><single cell ATAC-seq><single cell ATAC-sequencing><single cell Assay for Transposase Accessible Chromatin sequencing><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell next generation sequencing><single cell sequencing><single cell sequencing assay for transposase accessible chromatin><single cell transcriptomic profiling><single nucleotide variant><single-cell Assay for Transposase-Accessible Chromatin with sequencing><single-cell RNA sequencing><single-cell assay for transposase-accessible chromatin using sequencing><single-cell assay for transposase-accessible chromatin-seq><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><three dimensional><transcriptome><vertebrata><vertebrate embryos><whole genome association analysis><whole genome association study>
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Haopeng Xiao

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 16/100
Active award
$248,354
FY 2026

Project Title

Defining the landscape and mechanisms of redox regulation of metabolism during aging

Grant Number:

5R00AG073461-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2022

End Date:

12/31/2027

Project Abstract

PROJECT SUMMARY: Mammalian tissues engage in specialized physiology that is regulated through reversible modification of protein cysteine residues by reactive oxygen species (ROS). Despite the longstanding links between ROS dysregulation and aging, technological limitations have resulted in a persis...

Research Terms

<ATP1A2><ATP1A2 gene><Abnormal Assessment of Metabolism><Active Oxygen><Adipose tissue><Adrenergic Agents><Adrenergic Drugs><Adrenergics><Affect><Age><Aging><Animals><Atlases><Big Data><BigData><Biological Function><Biological Process><Biology><Biology of Aging><Body Tissues><Brown Adipose Tissue><Brown Fat><Caloric Restriction><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Communities><Cysteine><Data><Development><Disease><Disorder><Dysfunction><Energy Expenditure><Energy Metabolism><Environment><FHM2><Fatty Tissue><Functional disorder><Future><Gene Transcription><Genetic><Genetic Diversity><Genetic Transcription><Genetic Variation><Half-Cystine><Health Benefit><Heat Production><Hibernating Gland><Human><Increase lifespan><Individual><Intermediary Metabolism><Intervention><Intracellular Communication and Signaling><Investigators><Knowledge><L-Cysteine><Learning><Length of Life><Link><Liver><Longevity><Maps><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Mentors><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Processes><Metabolic Studies><Metabolism><Metabolism Studies><Methods><Mice><Mice Mammals><Mission><Mitochondria><Modeling><Modern Man><Modification><Molecular><Molecular Target><Murine><Mus><National Institute of Aging><National Institute on Aging><Obesity><Oxidation-Reduction><Oxidative Stress><Oxygen Radicals><Pathway interactions><Phase><Physiologic><Physiological><Physiology><Physiopathology><Play><Population><Population Heterogeneity><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Pro-Oxidants><Protein Family><Protein Modification><Proteins><Proteome><Proteomics><RNA Expression><Reactive Oxygen Species><Redox><Regulation><Research Personnel><Research Resources><Researchers><Resources><Role><Signal Transduction><Signal Transduction Systems><Signaling><Site><Technology><Testing><Thermogenesis><Thesaurismosis><Tissues><Transcription><Validation><Work><adipose><adiposity><age associated><age associated alterations><age associated changes><age associated decline><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent decline><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related decline><age specific><age specific alterations><age specific changes><aged><aged mice><aged mouse><ages><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><biological signal transduction><boost longevity><calorie restriction><changes with age><cohort><corpulence><decline with age><developmental><diverse populations><elderly mice><elongating the lifespan><enhance healthspan><enhance longevity><extend healthspan><extend life span><extend lifespan><extend longevity><extending healthy lifespan><foster longevity><healthspan><healthspan extension><healthy life span><hepatic body system><hepatic organ system><heterogeneous population><improve healthspan><improve lifespan><improve longevity><in vivo><increase healthspan><insight><intervention enhancing longevity><intervention to extend lifespan><intervention to improve lifespan><intervention to increase longevity><intervention to prolong lifespan><intervention to promote longevity><life span><lifespan><lifespan extending intervention><lifespan extending therapies><lifespan extension><lifespan improving intervention><lifespan increasing intervention><lifespan increasing therapies><lifespan intervention><lifespan prolonging interventions><lifespan promoting intervention><longevity boosting intervention><longevity extending intervention><longevity intervention><longevity promoting intervention><longevity therapy><longevity treatment><metabolic abnormality assessment><metabolism disorder><mitochondrial><mouse model><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new technology><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel technologies><novel therapeutics><novel therapy><old mice><oxidation><oxidation reduction reaction><pathophysiology><pathway><pharmacologic><population diversity><programs><prolong healthspan><prolong lifespan><prolong longevity><promote healthspan><promote lifespan><promote longevity><response><skills><social role><stoichiometry><strategy to enhance longevity><strategy to promote longevity><support longevity><therapeutic agent development><therapeutic development><translational opportunities><translational potential><translational therapeutics><translational therapy><validations><white adipose tissue><yellow adipose tissue>
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Jacqueline Giovanniello

TEMPLE UNIV OF THE COMMONWEALTH, PHILADELPHIA, PA

Exploratory lead · 16/100
Active award
$245,650
FY 2026

Project Title

Revealing the neural mechanisms of amygdala-striatal control of stress-induced habits

Grant Number:

5R00MH135177-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2027

Project Abstract

PROJECT SUMMARY: Updates: I am moving to a new position at Temple University Lewis Katz School of Medicine as an independent, tenure-track Assistant Professor in the Department of Neural Science. Here, I will conduct the R00 phase experiments and develop my own independent research program. The ove...

Research Terms

<16p11.2><ASD><ASD patient><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Animals><Autism><Autism Spectrum Disorder patient><Autistic Disorder><Behavior><Behavior Conditioning Therapy><Behavior Control><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Manipulation><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Brain><Brain Nervous System><Calcium><Cell Body><Cells><Characteristics><Chromosomal microdeletion><Chronic stress><Conditioning Therapy><Corpus Striatum><Corpus striatum structure><D1 receptor><DNA Alteration><DNA Sequence Alteration><Data><Data Analyses><Data Analysis><Decision Making><Doctor of Philosophy><Dopamine D1 Receptor><Dorsal><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Encephalon><Environment><Environmental Factor><Environmental Risk Factor><Equilibrium><Evaluation><Exposure to><Foundations><Funding><Future><Gene x Environment Interaction><Genes><Genetic><Genetic Alteration><Goals><GxE interaction><Habits><Human><Image><In vivo two-photon calcium imaging><Infantile Autism><Kanner's Syndrome><Knowledge><Learning><Measures><Mentors><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Outcome><Pathologic><Ph.D.><PhD><Phase><Population><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Predisposition><Research><Research Associate><Resolution><Rewards><Rodent><Rodentia><Rodents Mammals><Role><Science><Sequence Alteration><Slice><Stress><Striate Body><Striatum><Susceptibility><Synapses><Synaptic><System><Technical Expertise><Testing><Therapeutic><Training><Universities><Update><Work><amygdaloid nuclear complex><autism model><autism spectral disorder><autism spectrum disorder><autistic patient><autistic spectrum disorder><balance><balance function><behavior intervention><behavior phenotype><behavioral control><behavioral intervention><behavioral phenotyping><cell type><data interpretation><electrophysiological><endophenotype><environment effect on gene><environmental risk><experiment><experimental research><experimental study><experiments><gene environment interaction><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><genomic alteration><imaging><imaging approach><imaging based approach><improved><in vivo><in vivo calcium imaging><insight><learning outcome><maladaptive behavior><medical college><medical schools><microdeletion><model of autism spectrum disorder><mouse model><murine model><neural><neural mechanism><neuromechanism><neuronal><patient with ASD><post-doc><post-doctoral><post-doctoral trainee><premature><prematurity><professor><programs><prospective><research associates><resolutions><response><school of medicine><skills><social role><stress reduction><striatal><synapse><synergism><technical skills><tenure process><tenure track>
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Joanna-Lynn C Borgogna

MC LAUGHLIN RESEARCH INSTITUTE, GREAT FALLS, MT

Exploratory lead · 16/100
Active award
$244,811
FY 2026

Project Title

A multi-omic and integrative longitudinal evaluation of the role of lipid, antioxidant, and osmoprotectant metabolites in the genitourinary syndrome of menopause by race and ethnicity.

Grant Number:

4R00AG081495-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2023

End Date:

1/31/2029

Project Abstract

The genitourinary syndrome of menopause (GSM) is an age-related chronic, progressive urogenital condition that disproportionately affects postmenopausal women and contributes >$3 billion annually to US healthcare costs. The impact of GSM is extensive and affects >62 million US women. Racial and ethn...

Research Terms

<AD dementia><Advocate><Affect><Age><Age related pathologies><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Aminoacetic Acid><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antioxidants><Assay><Attenuated><Award><Bioassay><Biological Assay><Biological Markers><Blood Plasma><Blood Serum><Cardiovascular Diseases><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caucasian Females><Caucasian Women><Cellular injury><Cerebrospinal Fluid><Chronic><Chronology><Clinical><Clinical Data><Communities><Complex><Data><Development><Diagnosis><Diagnostic><Diagnostic Findings><Diet><Disparate><Doctor of Philosophy><Dryness><Epidemiology><Epithelial Cells><Estrogen Therapy><Estrogens><Ethnic Minority Women><Ethnic Origin><Ethnicity><Evaluation><Exposure to><First Generation College Students><First Generation College graduates><First Generation Students><Genitourinary><Genitourinary system><Glean><Glutathione><Glycine><Goals><Gynecologic><Health Care Costs><Health Costs><Human><Immunology><In Vitro><Inflammation><Inflammatory Response><Intermediary Metabolism><Intervention><Investigators><Itching><K-Awards><K-Series Research Career Programs><Knowledge><Latina><Link><Lipid Peroxidation><Lipids><Long-term cohort><Longitudinal cohort><Lubricants><Lubrication><Machine Learning><Mediating><Mediation><Medical><Menopausal Status><Menopausal Syndrome><Menopause Syndrome><Mentors><Metabolic Processes><Metabolism><Metabolite Interaction><Methods><Microbe><Microbiology><Modality><Modern Man><Modernization><Mucosa><Mucosal Tissue><Mucous Membrane><Negotiating><Negotiation><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Osmosis><Osteoporosis><Outcome><Oxidative Stress><Oxidative Stress Induction><Pain><Painful><Participant><Pathology><Ph.D.><PhD><Phase><Plasma><Plasma Serum><Population><Post-Menopause><Post-menopausal Period><Postmenopausal Period><Postmenopause><Predisposition><Preparation><Prevention><Primary Senile Degenerative Dementia><Process><Pruritic Disorder><Pruritis><Pruritus><Publications><QOL><Quality of life><Race><Races><Recurrence><Recurrent><Research><Research Career Program><Research Personnel><Researchers><Reticuloendothelial System, Serum, Plasma><Risk><Role><Sampling><Scientific Publication><Serum><Sex Functioning><Sexual Health><Sexually Transmitted Diseases><Sexually Transmitted Disorder><Sexually Transmitted Infection><Signs and Symptoms><Sphingolipids><Stress><Structural Models><Susceptibility><Symptoms><Therapeutic Agents><Therapeutic Estrogen><Urogenital><Urogenital System><Vagina><Validation><Venereal Diseases><Venereal Disorders><Venereal Infections><Vitamins><White Females><White Women><Woman><Work><Youth><Youth 10-21><after menopause><age associated><age associated disease><age associated disorder><age associated impairment><age associated pathologies><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age dependent pathologies><age induced pathologies><age linked><age related><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><ages><aging associated pathologies><aging dependent pathologies><aging induced pathologies><aging pathologies><aging related pathologies><alleviate symptom><ameliorating symptom><antioxidant therapy><attenuate><attenuates><bio-markers><biologic marker><biomarker><cardiovascular disorder><career><cell damage><cell injury><cellular damage><cerebral spinal fluid><childbearing age><cohort><cost><cytokine><damage to cells><decrease symptom><developmental><diets><early experience><epidemiologic><epidemiological><estrogen disrupting><estrogen disruption><estrogen hormone therapy><estrogen treatment><estrogenic disruption><ethnic minority><fat metabolism><fertile age><fewer symptoms><following menopause><gamma-L-Glu-L-Cys-Gly><gamma-L-Glutamyl-L-Cysteinylglycine><high risk><improved><infection rate><injury to cells><innovate><innovation><innovative><insight><itch sensation><lipid metabolism><machine based learning><machine learning based method><machine learning method><machine learning methodologies><marginalization><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><microbial consortia><microbial flora><microbial host><microbiome><microbiota><microflora><multiomics><multiple omics><multispecies consortia><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><older adult><older adulthood><older women><panomics><past menopause><personalized health intervention><personalized intervention><post-doctoral training><post-menopausal><postmenopausal><postmenopausal status><precision interventions><preparations><primary degenerative dementia><racial><racial background><racial minority><racial minority women><racial origin><rate of infection><reduce symptoms><relieves symptoms><reproductive><reproductive age><reproductive years><senile dementia of the Alzheimer type><sexual functioning><sexually acquired infection><side effect><skills><social role><social stigma><spinal fluid><statistics><stigma><symptom alleviation><symptom reduction><symptom relief><treated with estrogen><treatment with estrogen><vaginal flora><vaginal lactobacilli><vaginal microbial community><vaginal microbiota><vaginal microflora><validation studies><validations><youth age>
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Marcus Matthias Weera

TUFTS UNIVERSITY MEDFORD, Boston, MA

Exploratory lead · 16/100
Active award
$244,532
FY 2026

Project Title

Lateral Hypothalamus Circuits in Stress-Induced Blunting of Alcohol Aversion& Escalation of Alcohol Self-Administration

Grant Number:

5R00AA029726-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2022

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY (See instructions): Traumatic stress can lead to alcohol misuse and alcohol use disorder (AUD). In particular, avoidance coping after stress (i.e., persistent mental and/or physical avoidance of stress-related stimuli) is associated with higher rates of alcohol misuse. Using an ani...

Research Terms

<Acute><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohols><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Animal Model><Animal Models and Related Studies><Applications Grants><Area><Award><Bobcat><Brain><Brain Nervous System><Cell Communication and Signaling><Cell Signaling><Cessation of life><Common Rat Strains><Data><Death><Development><Development and Research><Dose><Encephalon><EtOH drinking><EtOH use><Exhibits><Exposure to><Faculty><Fiber><Foundations><Funding><Future><Genetic><Glutamates><Goals><Grant Proposals><Habenula><Heavy Drinking><Human><Hypothalamic structure><Hypothalamus><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Individual><Individual Differences><Institution><Instruction><Intracellular Communication and Signaling><Investigation><L-Glutamate><Lateral><Maintenance><Measures><Mediating><Mediator><Mentors><Modern Man><Nerve Cells><Nerve Unit><Neural Cell><Neurobiology><Neurocyte><Neurons><Neurosciences><Odors><Phase><Photometry><Position><Positioning Attribute><Prevention><Principal Investigator><Procedures><Psyche structure><Public Health><Publishing><R & D><R&D><Rat><Rats Mammals><Rattus><Research><Rewards><Role><Secure><Self Administered><Self Administration><Signal Transduction><Signal Transduction Systems><Signaling><Stimulus><Stress><Stress and Coping><Stressful Event><Techniques><Testing><Training><Training Support><Urine><Work><alcohol abuse therapy><alcohol abuse treatment><alcohol effect><alcohol ingestion><alcohol intake><alcohol misuse><alcohol product use><alcohol sensitivity><alcohol treatment><alcohol use><alcohol use disorder><alcoholic beverage consumption><alcoholic drink intake><amygdaloid nuclear complex><behavior test><behavioral test><biological signal transduction><career><career development><coping><coping with stress><data deposition><data submission><developmental><drink heavily><economic cost><ethanol consumption><ethanol drinking><ethanol effect><ethanol ingestion><ethanol intake><ethanol misuse><ethanol product use><ethanol sensitivity><ethanol use><ethanol use disorder><excessive alcohol consumption><excessive alcohol ingestion><excessive alcohol intake><excessive drinking><excessive ethanol ingestion><experiment><experimental research><experimental study><experiments><extreme drinking><gene testing><gene-based testing><genetic testing><glutamatergic><heavy alcohol use><hypothalamic><improved><in vivo><indexing><mental><model of animal><neural circuit><neural circuitry><neural mechanism><neurobiological><neurocircuitry><neuromechanism><neuronal><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><paired stimuli><programs><research and development><response><sensitivity to alcohol><sensitivity to ethanol><skill acquisition><skill development><social role><stress reactivity><stress-related coping><stressful experience><stressful life event><stressful life experience><synaptic circuit><synaptic circuitry><tenure process><tenure track><traumatic stress><unhealthy alcohol use>
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Natalie Riva Smith

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 16/100
Active award
$243,050
FY 2026

Project Title

Developing and evaluating a decision support tool to disseminate tobacco control research and inform policy implementation

Grant Number:

5R00CA277135-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Project Abstract

Adolescent use of electronic nicotine delivery systems (ENDS, or e-cigarettes) has increased rapidly and can lead to nicotine addiction and adversely affect brain development. Conversely, ENDS products can help adults quit smoking, decreasing their cancer risk. This creates a major tradeoff in risks...

Research Terms

<21+ years old><Administrator><Adolescent><Adolescent Youth><Adult><Adult Human><Adverse effects><Affect><Area><Assessment instrument><Assessment tool><Award><Benefits and Risks><Brain><Brain Nervous System><Cancer Control><Cancer Control Science><Cancers><Communication><Data><Decision Analysis><Decision Making><Development><Development Plans><Dissemination and Implementation><Education><Educational aspects><Effectiveness><Electronic Nicotine Delivery Product><Electronic Nicotine Delivery Systems><Electronic cigarette><Encephalon><Equilibrium><Foundations><Future><Goals><Health><Health Policy><History><Individual><Interview><Investigators><Legislation><Licensing><Literature><Malignant Neoplasms><Malignant Tumor><Mentorship><Methods><Nicotine Dependence><Phase><Pilot Projects><Policies><Policy Maker><Policy Making><Policy Research><Politics><Postdoc><Postdoctoral Fellow><Public Health><Public Health Schools><Public Policy><Publishing><Recommendation><Recording of previous events><Reporting><Research><Research Activity><Research Associate><Research Peer Review><Research Personnel><Research Resources><Researchers><Resources><Risk><Schools><Science><Scientist><Statutes and Laws><Taxes><Time><Tobacco Control Research><Training><Training Activity><Uncertainty><Variant><Variation><Weight><Work><adulthood><balance><balance function><cancer prevention><cancer risk><career><career development><cease smoking><cost><design><designing><developmental><dissemination science><dissemination strategy><doubt><e-cig><e-cigarette><ecig><ecigarette><economic analysis><economic assessment><economic evaluation><electronic nicotine delivery device><electronic nicotine distribution system><experience><experiment><experimental research><experimental study><experiments><flexibility><flexible><health care policy><health economics><histories><implementation research><implementation science><improved><informant><insight><interest><juvenile><juvenile human><malignancy><model-based simulation><models and simulation><neoplasm/cancer><new approaches><nicotine addiction><nicotine dependent><novel approaches><novel strategies><novel strategy><pilot study><post-doc><post-doctoral><post-doctoral trainee><prevent><preventing><public health research><public policy on tobacco><quit smoking><research associates><research data dissemination><research dissemination><smoking cessation><stop smoking><success><support tools><tobacco control policy><tobacco policy><tool><training module><weights>
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Nicholas M Timme

UNIVERSITY OF CINCINNATI, CINCINNATI, OH

Exploratory lead · 16/100
Active award
$241,669
FY 2026

Project Title

Identifying how alcohol-evoked changes in neural firing affect systems level computations during decision-making

Grant Number:

5R00AA028265-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/21/2023

End Date:

1/31/2027

Project Abstract

Project Summary The primary training objective of the K99 phase of this K99/R00 application is to provide the candidate with training in state-of-the-art electrophysiology techniques in preparation for a career as an independent investigator in the field of alcohol research. The overarching hypothes...

Research Terms

<Absolute ethanol><Acclimatization><Address><Affect><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohols><Animals><Anterior><Applications Grants><Area><Aversive Stimulus><Award><Behavior><Behavioral><Blood><Blood Reticuloendothelial System><Brain><Brain Nervous System><Brain region><Cell Body><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Collaborations><Cues><Data><Data Set><Decision Making><Disease><Disorder><ETOH><Educational workshop><Electrophysiology><Electrophysiology (science)><Encephalon><Environment><EtOH drinking><EtOH use><Ethanol><Ethyl Alcohol><Exhibits><Faculty><Fear><Foundations><Fright><Future><Goals><Grain Alcohol><Grant Proposals><Head><Hydrogen Oxide><Impairment><Individual><International><Intervention><Intracellular Communication and Signaling><Investigators><Journals><Laboratories><Magazine><Medial><Mentors><Methylcarbinol><Mice><Mice Mammals><Modification><Murine><Mus><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neurobiology><Neurocyte><Neuronal Transmission><Neurons><Neurophysiology / Electrophysiology><Pathology><Pattern><Performance><Persons><Phase><Population><Position><Positioning Attribute><Prefrontal Cortex><Preparation><Process><Protocol><Protocols documentation><Publishing><Quinine><Research><Research Personnel><Research Resources><Researchers><Resistance><Resolution><Resources><Rewards><Risk><Route><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><Synapses><Synaptic><System><Task Performances><Techniques><Testing><Time><Training><Ventral Striatum><Water><Work><Workshop><alcohol abuse therapy><alcohol abuse treatment><alcohol effect><alcohol exposed><alcohol exposure><alcohol ingestion><alcohol intake><alcohol product use><alcohol related research><alcohol research><alcohol reward><alcohol risk><alcohol treatment><alcohol use><alcohol use disorder><alcoholic beverage consumption><alcoholic drink intake><axon signaling><axon-glial signaling><axonal signaling><biological sex as a modifier><biological signal transduction><brain cell><career><career development><computational neuroscience><conference><convention><density><drinking><electrophysiological><ethanol consumption><ethanol drinking><ethanol effect><ethanol exposed><ethanol exposure><ethanol ingestion><ethanol intake><ethanol product use><ethanol research><ethanol reward><ethanol use><ethanol use disorder><experiment><experimental research><experimental study><experiments><exposed to alcohol><exposed to ethanol><exposure to alcohol><exposure to ethanol><flexibility><flexible><glia signaling><glial signaling><improved><insight><nerve signaling><neural><neural circuit><neural circuitry><neural correlate><neural signaling><neurobiological><neurocircuitry><neuronal><neuronal signaling><neurophysiological><neurophysiology><neurotransmission><novel><pharmacologic><preparations><reinforcer><repair><repaired><resistant><resolutions><sex as a biological factor><sex as a biological measure><sex as a biological risk factor><sex as a biological variable><sex as a biological variance><sex as a biologically significant variable><sex as a fundamental variable><spatial and temporal><spatial temporal><spatiotemporal><summit><symposia><symposium><synapse><synaptic circuit><synaptic circuitry><theories><tool><visual discrimination>
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Dahong Chen

STATE UNIVERSITY OF NEW YORK AT BUFFALO, AMHERST, NY

Exploratory lead · 16/100
Active award
$240,540
FY 2026

Project Title

Chromatin insulator-mediated epigenetic regulation of neuronal remodeling during development.

Grant Number:

5R00HD097308-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/17/2024

End Date:

12/31/2026

Project Abstract

Project Summary/Abstract Dysfunction and death of neurons severely affect the quality of life, yet therapeutic options remain limited. Recent studies demonstrated clinic potential to replace lost neurons, e.g., transplanting of hESC- derived retinal cells improves disrupted visual acuity. However, ...

Research Terms

<21+ years old><3-D><3-Dimensional><3D><4C-seq><ASD><ATAC sequencing><ATAC-seq><ATACseq><Adult><Adult Human><Affect><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Autism><Autistic Disorder><Automobile Driving><Award><Axon><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Biologic Models><Biological Assay><Biological Models><Blindness><Cell Body><Cell Function><Cell Maturation><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><ChIP Sequencing><ChIP-seq><ChIPseq><Childhood><Chromatin><Chromatin Conformation Capture and Sequencing><Chromatin Structure><Clinic><Coupled><DNA><DNA-Binding Proteins><Data><Deoxyribonucleic Acid><Development><Diamond><Disease><Disorder><Drosophila><Drosophila genus><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Flies><Functional disorder><Funding><Gene Down-Regulation><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Transcription><Genetic study><Goals><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Human><Infantile Autism><Kanner's Syndrome><Knowledge><Libraries><Location><Mediating><Medical><Mentors><Mice><Mice Mammals><Model System><Modeling><Modern Man><Molecular><Monitor><Morphogenesis><Morphology><Murine><Mus><Neonatal><Nerve Cells><Nerve Unit><Nervous System><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurites><Neurocyte><Neurologic Body System><Neurologic Disorders><Neurologic Organ System><Neurological Disorders><Neurons><Neurophysiology / Electrophysiology><Neurosciences><Non-Polyadenylated RNA><Nuclear Lamina><Ortholog><Orthologous Gene><Phase><Physiologic><Physiological><Physiology><Physiopathology><Play><Process><Proteins><Puberty><QOL><QOL improvement><Quality of life><RNA><RNA Expression><RNA Gene Products><Regulation><Repression><Research><Research Resources><Resources><Retina><Retinal Ganglion Cells><Ribonucleic Acid><Role><Scientist><Sex Maturation><Sexual Maturation><Signal Pathway><Subcellular Process><Technical Expertise><Techniques><Testing><Therapeutic><Training><Transcription><Transcription Factor Proto-Oncogene><Transcription Repression><Transcription factor genes><Universities><Validation><Vertebrate Animals><Vertebrates><Visual Acuity><Visualization><adulthood><antagonism><antagonist><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><career><career development><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><developmental><driving><electrophysiological><epigenetic regulation><epigenetically><fly><fruit fly><gangliocyte><ganglion cell><gene repression><genome scale><genome-wide><genomewide><global gene expression><global transcription profile><hESC transplantation><human ESC transplantation><human embryonic stem cell grafting><human embryonic stem cell transplantation><improved><improvements in QOL><improvements in quality of life><inhibitor><insight><morphogenetic process><mouse model><murine model><nerve cell death><nerve cell loss><neurological disease><neuron cell death><neuron cell loss><neuron death><neuron development><neuron loss><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal development><neuronal loss><novel><overexpress><overexpression><pathophysiology><pediatric><programs><promoter><promotor><protein complex><quality of life improvement><recruit><retinal ganglion><social role><technical skills><three dimensional><tool><transcription factor><transcriptome><validations><vertebrata><vision loss><visual loss>
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Josiah E Hardesty

UNIVERSITY OF LOUISVILLE, LOUISVILLE, KY

Exploratory lead · 16/100
Active award
$238,897
FY 2026

Project Title

Restoration and preservation of hepatic cardiolipin levels promotes liver regeneration in AH

Grant Number:

5R00AA030627-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/21/2022

End Date:

11/30/2026

Project Abstract

Project Summary/Abstract: Alcohol-associated hepatitis (AH) is a clinical manifestation of alcohol-associated liver disease (ALD) that has a very poor prognosis. Current treatments are ineffective and liver transplantation is the only long-term solution. The liver has the unique ability to regenerat...

Research Terms

<(TNF)-α><4-O-alpha-D-glucopyranosyl-D-glucose><ATP Synthesis><ATP Synthesis Pathway><Absolute ethanol><Affect><Alcohol Chemical Class><Alcohol associated hepatitis><Alcohol hepatitis><Alcohol induced hepatitis><Alcohol related hepatitis><Alcoholic><Alcoholic Hepatitis><Alcoholic Liver Diseases><Alcoholic liver damage><Alcohols><Animal Model><Animal Models and Related Studies><Animals><Apoptosis><Apoptosis Pathway><Assay><Binding><Bioassay><Bioenergetics><Biogenesis><Biological Assay><Biological Markers><Blood Plasma><Boozer><Cachectin><Cardiolipins><Cell Body><Cells><Cessation of life><Clinical><Clinical Trials><Culture Media><Data><Death><Death Rate><Dependent drinker><Dextrins><Dose><Drugs><ETOH><Enzyme Gene><Enzymes><Ethanol><Ethanol-induced hepatitis><Ethyl Alcohol><Euthanasia><Evaluation><Experimental Animal Model><Ferricytochrome c><Ferrocytochrome c><Foundations><Galactosamine><Genes><Genus Hippocampus><Grain Alcohol><Hepatic><Hepatic Cells><Hepatic Disorder><Hepatic Insufficiency><Hepatic Parenchymal Cell><Hepatic Transplantation><Hepatic mitochondria><Hepatitis><Hepatocyte><Human><Immune><Immunes><Impairment><In Vitro><Inflammation><Inflammatory Response><Injections><Injury><Investigators><Lead><Lipids><Liver><Liver Cells><Liver Grafting><Liver Insufficiency><Liver Mitochondria><Liver Regeneration><Liver Transplant><Liver diseases><LoxP-flanked allele><Macrophage-Derived TNF><Maintenance><Maltose><Measurement><Mediating><Medication><Mercy Killing><Methylcarbinol><Mice><Mice Mammals><Mitochondria><Mitochondrial Myopathies><Modeling><Modern Man><Molecular Interaction><Monocyte-Derived TNF><Murine><Mus><Natural regeneration><Origin of Life><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><PBMC><Partial Hepatectomy><Pathway interactions><Patients><Pb element><Peripheral Blood Mononuclear Cell><Pharmaceutical Preparations><Phase><Phosphatides><Phospholipids><Plasma><Plasma Serum><Population><Preclinical data><Prevention><Process><Prognosis><Programmed Cell Death><Proliferating><Proliferation Marker><Proteins><Regeneration><Regimen><Research><Research Personnel><Researchers><Respiratory Chain><Reticuloendothelial System, Serum, Plasma><Rodent><Rodentia><Rodents Mammals><Role><Safety><Sampling><Seahorse><Solid><Sorting><Structure><Supplementation><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Tail><Testing><Therapeutic><Training><Translations><Treatment Efficacy><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Veins><Vesicle><Viral><Viral Genome><alcohol induced hepatic injury><alcohol induced liver disorder><alcohol induced liver injury><alcohol liver damage><alcohol related liver disease><alcohol-associated liver disease><alcohol-induced hepatic damage><alcohol-induced hepatic dysfunction><alcohol-induced liver damage><alcohol-induced liver disease><alcohol-induced liver dysfunction><alcohol-mediated liver dysfunction><alcohol-mediated liver injury><alcohol-related liver disease><alcoholic liver injury><alternative treatment><bio-markers><biologic marker><biomarker><chronic hepatic disease><chronic hepatic disorder><chronic liver disease><chronic liver disorder><cytochrome c><cytokine><disease control><disorder control><drug/agent><ethanol induced hepatic injury><ethanol induced liver disorder><ethanol induced liver injury><ethanol liver disease><ethanol-induced hepatic damage><ethanol-induced hepatic dysfunction><ethanol-induced liver damage><ethanol-induced liver disease><ethanol-induced liver dysfunction><ethanol-mediated liver dysfunction><ethanol-mediated liver injury><feeding><floxed><floxed allele><growth media><heavy metal Pb><heavy metal lead><hepatic body system><hepatic cell proliferation><hepatic cellular proliferation><hepatic disease><hepatic organ system><hepatocyte cell proliferation><hepatocyte cellular proliferation><hepatocyte injury><hepatocyte proliferation><hepatopathy><improved><in vitro Model><ineffective therapies><ineffective treatment><injuries><intervention arm><intervention efficacy><lipidomics><liver cell proliferation><liver cellular proliferation><liver disorder><liver function><liver transplantation><male><mitochondrial><mitochondrial dysfunction><mitochondrial membrane><model of animal><mortality rate><novel><oxidation><partial excision of liver><particle><pathway><patient prognosis><pharmacologic><pre-clinical><pre-clinical study><preclinical><preclinical findings><preclinical information><preclinical study><preservation><prevent><preventing><problem drinker><regenerate><response><restoration><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><subtotal hepatectomy><therapeutic efficacy><therapeutically effective><therapy efficacy><translation><treatment arm><treatment strategy><virus genome><♂>
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Lukas Martin Weber

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Exploratory lead · 16/100
Active award
$237,513
FY 2026

Project Title

Unsupervised Statistical Methods for Data-driven Analyses in Spatially Resolved Transcriptomics Data

Grant Number:

5R00HG012229-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2026

Project Abstract

Project Summary/Abstract Recently developed spatially resolved transcriptomics (ST) technologies measure transcriptome-wide gene expression at a near-single-cell, single-cell, or sub-cellular resolution in intact tissue, preserving the spatial organization of complex tissues. These technologies buil...

Research Terms

<2-dimensional><Address><Adopted><Award><Awareness><Benchmarking><Best Practice Analysis><Biological><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Classification><Communities><Complex><Computer software><Data><Data Analyses><Data Analysis><Data Set><Data Storage and Retrieval><Development><Diagnosis><Dimensions><Disease><Disorder><EXTMR><Evaluation><Expression Profiling><Expression Signature><Extramural><Extramural Activities><Faculty><Funding><Gene Expression><Gene Expression Profile><Gene Transcription><Generations><Genes><Genetic Markers><Genetic Transcription><Goals><Health><Heterogeneity><Human><Individual><Institution><Intracellular Communication and Signaling><Investigators><Knowledge><Machine Learning><Measurement><Measures><Mentors><Methodology><Methods><Modern Man><Molecular><Nature><Non-Polyadenylated RNA><Outcome><Pathway interactions><Pattern><Phase><Population><Position><Positioning Attribute><Procedures><Prognosis><Property><Quality Control><RNA><RNA Expression><RNA Gene Products><Research><Research Personnel><Research Resources><Researchers><Resolution><Resources><Ribonucleic Acid><Signal Transduction><Signal Transduction Systems><Signaling><Software><Specificity><Spottings><Standardization><Statistical Methods><Systematic Bias><Systematics><Techniques><Technology><Time><Tissue Arrays><Tissue Chip><Tissue Microarray><Tissues><Training><Transcript><Transcription><Variant><Variation><Weight><Work><benchmark><biologic><biological signal transduction><career><cell type><complex data><data infrastructure><data interpretation><data resource><data retrieval><data standardization><data standards><data storage><density><design><designing><developmental><feature selection><gene biomarker><gene expression biomarker><gene expression pattern><gene expression signature><gene marker><gene signature biomarker><genetic biomarker><global gene expression><global transcription profile><improved><insight><machine based learning><novel><open source><pathway><precision medicine><precision-based medicine><preservation><resolutions><response to therapy><response to treatment><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><statistic methods><statistics><tenure process><tenure track><therapeutic response><therapy response><tool><transcriptional profile><transcriptional signature><transcriptome><treatment response><treatment responsiveness><two-dimensional><unsupervised clustering><weights>
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Takushi Miyoshi

SOUTHERN ILLINOIS UNIVERSITY CARBONDALE, CARBONDALE, IL

Exploratory lead · 16/100
Active award
$236,394
FY 2026

Project Title

Advanced microscope technologies for single-molecule functional analyses of stereocilia components necessary for normal human hearing

Grant Number:

5R00DC019949-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2026

Project Abstract

Project Summary/Abstract Sensorineural hearing loss affects 20% of the population in the United States at all ages. A normal acoustic sense requires a variety of cells in the inner ear, in the brain and on neuronal pathways. In the inner ear, stereocilia on the apical surface of hair cells function ...

Research Terms

<0-11 years old><21+ years old><Acoustics><Actin Filaments><Actins><Adult><Adult Human><Affect><Age><Animals><Apical><Area><Award><Binding><Biological><Body System><Brain><Brain Nervous System><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Child><Child Youth><Children (0-21)><Clinical><Comb animal structure><Combs><Corti Cell><Cryo-electron Microscopy><Cryo-electron tomography><Cryoelectron Microscopy><Cultured Cells><DNA Recombination><Data><Development><Dimensions><Disease><Disorder><Dissociation><Dysfunction><Electron Cryomicroscopy><Electron Microscopy><Encephalon><Engineering><F-Actin><Family><Filamentous Actin><Fluorescence Agents><Fluorescent Agents><Fluorescent Dyes><Functional disorder><Future><Gene variant><Genes><Genetic Recombination><Goals><Gold><Hair Cells><Hearing><Hearing Loss><Human><Hypoacuses><Hypoacusis><Illumination><Image><Individual><Inner Hair Cells><Inner ear hair cells><Internal Ear><Investigators><Kinetics><Knowledge><Label><Laboratories><Labyrinth><Learning><Light><Lighting><Mechanics><Mentors><Methodology><Methods><Mice><Mice Mammals><Microfilaments><Microscope><Microscopy><Microvilli><Microvillus><Modeling><Modern Man><Molecular><Molecular Dynamics Simulation><Molecular Interaction><Movement><Murine><Mus><Mutant Strains Mice><Myofilaments><NHLBI><NIBIB><NIDCD><NIH><National Heart, Lung, and Blood Institute><National Institute of Biomedical Imaging and Bioengineering><National Institute on Deafness and Other Communication Disorders><National Institutes of Health><Natural regeneration><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Organ System><Organelles><Pathogenicity><Pathology><Pathway interactions><Persons><Phase><Photoradiation><Physiopathology><Population><Prevalence><Process><Proteins><Recombination><Regeneration><Regulatory Protein><Reporting><Research><Research Personnel><Researchers><Resolution><Sampling><Sensorineural Deafness><Sensorineural Hearing Loss><Sensory Hearing Loss><Single-Nucleus Sequencing><Speech Development><Staining method><Stains><Strepavidin><Streptavidin><Structure><Subcellular Process><Surface><Techniques><Technology><Time><Training><Transgenic Mice><United States><United States National Institutes of Health><Visualization><adulthood><ages><allelic variant><beta Actin><biologic><body movement><candidate identification><career><cellular microvillus><cofilin><cognitive function><cryo-EM><cryo-EM tomography><cryoEM><cryoEM tomography><cryoelectron tomography><cryogenic electron microscopy><deafness><deep learning><deep learning method><deep learning strategy><developmental><dysfunctional hearing><ear hair cell><electron cryo-tomography><experiment><experimental research><experimental study><experiments><fluorescent dye/probe><genetic regulatory protein><genetic variant><genomic variant><gold nano particle><gold nanoparticle><good hearing><healthy hearing><hearing challenged><hearing defect><hearing deficient><hearing deficit><hearing difficulty><hearing dysfunction><hearing impairment><high resolution imaging><imaging><in vivo><inducible expression><inducible gene expression><inner ear><kids><language ability><language skills><life span><lifespan><light microscopy><mechanic><mechanical><molecular dynamics><monomer><mouse model><mouse mutant><murine model><mutant><nano gold><nanoGold><neuronal><normal hearing><novel><particle><pathophysiology><pathway><regenerate><regulatory gene product><repair><repaired><resolutions><sNuc-Seq><segregation><sensorineural hearing impairment><single molecule><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><skills><snRNA sequencing><snRNA-seq><superresolution microscopy><therapeutic target><trafficking><transcriptomics><treadmill><youngster><β-Actin>
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Snehal N. Chaudhari

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Exploratory lead · 16/100
Active award
$235,721
FY 2026

Project Title

Elucidating the role of the microbiome in inducing gut permeability and inflammation

Grant Number:

5R00DK128503-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2026

Project Abstract

Project Summary/Abstract Background – The microbiome affects host metabolism predominantly via metabolites synthesized or modified by gut bacteria. The identity of these metabolites and their mechanisms of action in the host remain largely unknown. Overarching metabolomic analyses have offered a gli...

Research Terms

<Acute><Affect><Assay><Attention><Automobile Driving><Autoregulation><Bacteria><Basal Transcription Factor><Basal transcription factor genes><Bile><Bile Acids><Bile Juice><Bile fluid><Binding Sites><Bioassay><Biochemical><Bioinformatics><Biological Assay><Biopsy><CRISPR><CRISPR/Cas system><Carbon><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chronic><Cirrhosis><Clustered Regularly Interspaced Short Palindromic Repeats><Collaborations><Colon><Combining Site><Common Rat Strains><Country><Coupled><Data><Development><Disease><Disorder><Epithelial Cells><Extracellular Signal-Regulated Kinase Gene><Fatty Liver><Feces><Folate><Folate fortification><Folic Acid><Folic acid fortification><Functional Metagenomics><Gene Transcription><General Hospitals><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genetic><Genetic Transcription><Germ-Free><Goals><Growth><Gut Epithelial Permeability><Gut Epithelium><Gut Hyperpermeability><Gut permeability><Health><Hepatic Cirrhosis><Hepatic Disorder><High Throughput Assay><Homeostasis><Human><Hydrolase><Hydrolase Family Gene><Hydrolase Gene><In Vitro><In vivo analysis><Incubated><Individual><Induction of Apoptosis><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intermediary Metabolism><Intestinal><Intestinal Absorption><Intestinal Content><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Intestines><Intracellular Communication and Signaling><Libraries><Link><Liver><Liver Cirrhosis><Liver Steatosis><Liver diseases><MAP Kinase Gene><MAP kinase><MAPK><Macrophage><Massachusetts><Measures><Mediating><Metabolic Processes><Metabolic syndrome><Metabolism><Metagenomics><Mice><Mice Mammals><Microbiomics><Mitochondria><Mitogen-Activated Protein Kinase Gene><Mitogen-Activated Protein Kinases><Modern Man><Morphology><Murine><Mus><Mφ><NASH><Nutrient><Obesity><Occluding Junctions><Pathogenesis><Pathway interactions><Patients><Phase><Phase Transition><Phenotype><Physiological Homeostasis><Pilot Projects><Policies><Portal Vein><Portal vein structure><Production><Prognosis><Proteins><Pteroylglutamic Acid><Public Health><RNA Expression><Rat><Rats Mammals><Rattus><Reactive Site><Receptor Activation><Receptor Signaling><Research><Rodent><Rodent Model><Rodentia><Rodents Mammals><Role><Sampling><Severities><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Targeted Research><Techniques><Testing><Therapeutic><Tight Junctions><Tissue Growth><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Upregulation><Vitamin M><Work><Zonula Occludens><absorption><adiposity><bacteria in the gut><bariatric surgery><bile salts><biological signal transduction><bowel><bowel inflammation><choline deficient diet><cirrhotic><co-morbid><co-morbidity><cohort><comorbidity><corpulence><developmental><dietary><disease prognosis><disease prognostication><driving><fecal sample><folate carrier><folate receptor><folate-binding protein><folate-methotrexate transporter><folic acid binding protein><folic acid receptor><gastric banding><gastric bypass surgery><gastrointestinal absorption><gastrointestinal epithelium><gastrointestinal homeostasis><gut bacteria><gut inflammation><hepatic body system><hepatic disease><hepatic organ system><hepatic steatosis><hepatopathy><hepatosteatosis><high throughput screening><ileum><implantable gastric stimulation banding><in vivo evaluation><in vivo testing><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><inflammatory modulation><inhibitor><intestinal autoinflammation><intestinal epithelium><intestinal homeostasis><intestinal inflammation><liver disorder><medical college><medical schools><metabolic engineering><metabolism measurement><metabolomics><metabonomics><methotrexate-binding protein><microbial><microbiome><microbiome intervention><microbiome research><microbiome science><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><mitochondrial><non-alcohol induced steatohepatitis><non-alcoholic steato-hepatitis><non-alcoholic steatohepatitis><nonalcoholic steato-hepatitis><nonalcoholic steatohepatitis><novel><obesity surgery><ontogeny><pathway><pilot study><prevent><preventing><school of medicine><screening><screenings><small molecule><social role><stomach stapling><stool><stool sample><stool specimen><therapeutic agent development><therapeutic development><transcription factor><vitamin Bc><weight loss surgery>
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Thomas Stoeger

NORTHWESTERN UNIVERSITY, Chicago, IL

Exploratory lead · 16/100
Active award
$234,812
FY 2026

Project Title

Integrative Multi-Scale Systems Analysis of Gene-Expression-Driven Aging Morbidity

Grant Number:

5R00AG068544-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2020

End Date:

12/31/2026

Project Abstract

Project Summary In a well-received preprint, the investigator identified through unbiased analysis of own and published datasets that during aging, and infection of the lung with influenza A, there is a progressive imbalance in the transcript levels encoded by short genes relative to those encoded b...

Research Terms

<21+ years old><Address><Adult><Adult Human><Aging><Area><Autoregulation><Biochemical><Bioethics><Biology of Aging><Biomedical Ethics><Body Tissues><Brain><Brain Nervous System><Buffers><Cause of Death><Cell Function><Cell Line><Cell Physiology><Cell Process><CellLine><Cellular Function><Cellular Immune Function><Cellular Physiology><Cellular Process><Cellular Stress><Cellular Stress Response><Cellular biology><Collaborations><Communicable Diseases><Complex><Data><Data Science><Data Scientist><Data Set><Disease><Disorder><Drug Screening><Dysfunction><Economic Burden><Elderly><Elements><Embryo><Embryonic><Encephalon><Ensure><Epithelium><Failure><Foundations><Functional disorder><Funding><GTEx><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Transcription><Genes><Genetic Transcription><Genome><Genotype-Tissue Expression Project><Geroscience><Gln><Global Change><Glutamine><Grant><Health><Heat Shock><Heat-Shock Reaction><Heat-Shock Response><Heterozygote><Homeostasis><Human><Human Cell Line><Immune><Immunes><Immunologist><Impairment><In Vitro><Individual><Infection><Infectious Diseases><Infectious Disorder><Inflammatory Response><Influenza A><Influenza A virus><Influenza Viruses Type A><Influenzavirus A><Intervention Strategies><Investigators><L-Glutamine><L-Proline><Laboratories><Lead><Learning><Learning Skill><Length><Life><Link><Lung><Lung Diseases><Lung Respiratory System><Lung infections><Machine Learning><Macromolecular Complexes><Mentors><Mentorship><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Morbidity><Murine><Mus><Non-Polyadenylated RNA><Older Population><Organ><Orthomyxovirus Type A><Pathway interactions><Pb element><Phase><Physiological Homeostasis><Physiopathology><Pneumonia><Polymerase><Postdoc><Postdoctoral Fellow><Predisposition><Printing><Process><Proline><Proteome><Publishing><Pulmonary Diseases><Pulmonary Disorder><Q Levoglutamide><Q. Levoglutamide><RNA><RNA Expression><RNA Gene Products><RNA Seq><RNA Splicing><RNA metabolism><RNA sequencing><RNAseq><Recovery><Regulation><Reporting><Research><Research Associate><Research Personnel><Researchers><Ribonucleic Acid><Running><Scientist><Site><Splicing><Stimulus><Strains Cell Lines><Stress><Subcellular Process><Supervision><Susceptibility><System><Systems Analyses><Systems Analysis><Techniques><Testing><Tissues><Training><Training Programs><Transcript><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Type A Influenza><United States><Upregulation><Viral Diseases><Virus Diseases><Work><Writing><aberrant aging><abnormal aging><adulthood><advanced age><age associated><age associated alterations><age associated changes><age associated decline><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent decline><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related decline><age specific><age specific alterations><age specific changes><aged><aged animal><aged animals><aged group><aged groups><aged individual><aged individuals><aged mice><aged mouse><aged people><aged person><aged persons><aged population><aged populations><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging morbidity><aging population><aging related alterations><aging related changes><aging resilience><aging specific alterations><aging specific changes><alterations with age><analyze gene expression><animal old age><biological adaptation to stress><cell age><cell biology><cell stress><cellular age><changes with age><cultured cell line><decline with age><disease of the lung><disorder of the lung><dysfunctional age related change><dysfunctional aging><elderly animal><elderly mice><enhance healthspan><extend healthspan><extending healthy lifespan><flu infection><flu virus infection><gene expression analysis><gene expression assay><genome scale><genome-wide><genomewide><geriatric><geroscientific><global gene expression><global transcription profile><healthspan extension><heavy metal Pb><heavy metal lead><heterozygosity><immune function><impaired aging><improve healthspan><in vivo><in vivo Model><increase healthspan><infected with flu><infected with flu virus><infected with influenza><infected with influenza virus><influenza A pneumonia><influenza infection><influenza virus infection><innovate><innovation><innovative><interest><loss of function><lung disorder><machine based learning><maladaptive aging><mortality><mouse model><multimorbidity><multiple chronic conditions><murine model><natural aging><new approaches><normal aging><normative aging><novel><novel approaches><novel strategies><novel strategy><old animals><old mice><older groups><older individuals><older person><overexpress><overexpression><pathological age related changes><pathological aging><pathophysiology><pathway><pneumonia model><pneumonia models><population aging><post-doc><post-doctoral><post-doctoral trainee><post-doctoral training><programs><prolong healthspan><promote healthspan><protein homeostasis><proteostasis><pulmonary infections><reactioncrisis><research associates><resilience><resilience during aging><resilience in aging><resilience in normal aging><resilience to aging><resilience with aging><resilient><resilient aging><resilient to aging><response><senior citizen><social><stoichiometry><stress response><stressreaction><transcriptional profiling><transcriptome><transcriptome sequencing><transcriptomic sequencing><transcriptomics><viral infection><virus infection><virus-induced disease>
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Natalie McCormick

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 16/100
Active award
$224,101
FY 2026

Project Title

Metabolic syndrome, chronic inflammation, and gout: a multi-omics approach

Grant Number:

5R00AR080243-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

12/31/2027

Project Abstract

Gout, an inflammatory arthritis affecting 9 million US adults, is characterised by painful flares, joint damage, and premature mortality. Gout frequently coexists with the metabolic (insulin resistance) syndrome (MetS) and its cardiometabolic sequalae, but the nature of these associations remains co...

Research Terms

<21+ years old><ACRP30 protein><Active Follow-up><Adult><Adult Human><Affect><Alpha Interleukin 2 Receptor><Area><Arthritis><Award><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Bioinformatics><Biological><Blood Plasma><Blood leukocyte><Branched-Chain Amino Acids><C-Peptide><C-reactive protein><CD 120a Antigen><CD120a Antigens><Candidate Disease Gene><Candidate Gene><Chinese><Chronic><Clinical><Complex><Data><Data Analytics><Development><Dietary Assessment><Dimensions><Disease><Disorder><Epidemiologist><Epidemiology><Flare><Follow-Up Studies><Food><Foundations><Free Fatty Acids><Frequencies><Future><GTEx><GWA study><GWAS><Gene variant><General Hospitals><Genes><Genetic><Genetic Markers><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Genomics><Genotype-Tissue Expression Project><Gout><HPGF><Health Care Professional><Health Professional><Hepatocyte-Stimulating Factor><Hybridoma Growth Factor><Hyperinsulinemia><Hyperinsulinism><Hyperuricemia><IFN-beta 2><IFNB2><IL-2Ralpha><IL-2Rα><IL-6><IL6 Protein><Inflammasome><Inflammation><Inflammatory><Inflammatory Arthritis><Inherited Predisposition><Inherited Susceptibility><Insulin Resistance><Intake><Interleukin-6><Japanese><Knowledge><Leukocytes><Leukocytes Reticuloendothelial System><Life Style><Lifestyle><Low Affinity Interleukin 2 Receptor><MGI-2><Marrow leukocyte><Mediating><Mediterranean Diet><Mentors><Meta-Analysis><Metabolic><Metabolic syndrome><Methodology><Methods><Musculoskeletal Pain Disorder><Myeloid Differentiation-Inducing Protein><NIAMS><National Institute of Arthritis, and Musculoskeletal, and Skin Diseases><Nature><Nested Case-Control Study><Nonesterified Fatty Acids><Nurses' Health Study><Obesity Epidemic><Oxidative Stress><Pain><Painful><Pathogenesis><Pathway interactions><Pattern><Pilot Projects><Plasma><Plasma Serum><Plasmacytoma Growth Factor><Position><Positioning Attribute><Precipitation><Predisposition><Premature Mortality><Prevention><Prospective, cohort study><Proteins><Proteins, specific or class, C-reactive><Proteome><Proteomics><Regulatory Element><Research><Research Resources><Resources><Reticuloendothelial System, Serum, Plasma><Rheumatic Diseases><Rheumatism><Rheumatologic Diseases><Rheumatologic Disorder><Risk><Risk Factors><Role><Susceptibility><Syndrome><System><Systems Biology><TNF Receptor p55><TNF-sR55><TNF-α receptor><TNFAR><TNFR p60><TNFR, 55-kD><TNFR, 60-kD><TNFR-I><TNFR1><TNFR55><TNFR60><TNFRSF1A><TNFRSF1A Receptor><TNFRSF1A gene><TNFalpha receptor><TNFα receptor><TOPMed><Training><Trans-Omics for Precision Medicine><Tumor Necrosis Factor Receptor 1><Tumor Necrosis Factor Receptor 55><Urate><White Blood Cells><White Cell><Work><active followup><adipocyte complement-related protein 30-kDa><adipocyte, C1q and collagen domain containing protein><adiponectin><adulthood><allelic variant><alpha-subunit, receptor, interleukin-2><apM-1 protein><apM1 (adipose-specific) protein><arthritic><biobank><biologic><biorepository><branched amino acids><cardiometabolic><cardiometabolism><career><case control><case-controlled><circulating biomarkers><circulating markers><clinical care><co-morbid><co-morbidity><comorbidity><connecting peptide><cost><developmental><diet adherence><dietary><dietary adherence><entire genome><epidemiologic><epidemiological><follow up><follow-up><follow-up research study><follow-up survey><followed up><followup><full genome><gene biomarker><gene expression biomarker><gene marker><gene signature biomarker><genetic architecture><genetic association><genetic biomarker><genetic variant><genetic vulnerability><genetically predisposed><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic data><genomic dataset><genomic variant><global gene expression><global transcription profile><high dimensional data><high dimensionality><improved><indexing><inflammation marker><inflammatory marker><innovate><innovation><innovative><insight><insulin resistant><insulin tolerance><interferon beta 2><interleukin-2Ralpha><joint damage><joint injury><joint trauma><machine learning based method><machine learning based model><machine learning method><machine learning methodologies><machine learning model><malleable risk><men><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><modifiable risk><multidimensional data><multidimensional datasets><multidisciplinary><multiomics><multiple omics><novel><panomics><pathway><pilot study><polygenic predictors><polygenic scores><population health><precipitations><prevent><preventing><prospective><response><skills><social role><study with follow-up><systemic inflammation><systemic inflammatory response><training opportunity><trait><transcriptome><transcriptomics><tumor necrosis factor alpha receptor><tumor necrosis factor receptor 1A><tumor necrosis factor α receptor><uricacidemia><white blood cell><white blood corpuscle><whole genome><whole genome association analysis><whole genome association study>
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Xiaotang Lu

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Exploratory lead · 16/100
Active award
$224,100
FY 2026

Project Title

New Methodologies for Connectomics

Grant Number:

5R00MH128891-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2022

End Date:

10/31/2027

Project Abstract

PROJECT ABSTRACT The nervous systems of animals are comprised of neurons connected by a large number of synapses. The resulting neural networks underlie animal behavior and contribute to the storage of learned information in many species. In humans, the miswiring of neural networks likely results in...

Research Terms

<Aging><Animal Behavior><Animals><Axon><BRAIN initiative><Behavior Disorders><Binding><Biochemistry><Biological Chemistry><Body Tissues><Brain><Brain Nervous System><Brain Research through Advancing Innovative Neurotechnologies initiative><Brain imaging><Brain region><Callithrix><Career Choice><Career Path><Cell Body><Cells><Cellular biology><Characteristics><Chemistry><Chimera Protein><Chimeric Proteins><Clinical Treatment Moab><Collaborations><Color><Conventional X-Ray><Core Facility><DNA Molecular Biology><Data Set><Dendrites><Development><Dimensions><Disease><Disorder><Educational workshop><Effectiveness><Electron Microscopy><Electrons><Encephalon><Ensure><Environment><Fluorescence Light Microscopy><Fluorescence Microscopy><Foundations><Funding><Fusion Protein><Future><Goals><Grant><Hapale><Heavy Metals><Human><Image><Immunization><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Investigation><Knowledge acquisition><Label><Lanthanides><Lanthanoid Series Elements><Lanthanoids><Learning><Libraries><Light><Maps><Marmosets><Membrane><Mentors><Mentorship><Metals><Methodology><Methods><Mice><Mice Mammals><Microscopic><Microscopy><Modern Man><Molecular><Molecular Biology><Molecular Interaction><Molecular and Cellular Biology><Monoclonal Antibodies><Multimodal Imaging><Murine><Mus><Negative Beta Particle><Negatrons><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neurobiology><Neurocyte><Neurologic Body System><Neurologic Organ System><Neurons><Neurosciences><Os element><Osmium><Permeability><Phase><Photoradiation><Position><Positioning Attribute><Preparation><Probability><Process><Property><Proteins><Protocol><Protocols documentation><Reagent><Research><Research Design><Resolution><Roentgen Rays><Running><Sampling><Series><Short-Tusked Marmoset><Staining method><Stains><Structure><Students><Study Type><Synapses><Synaptic><Technology><Time><Tissue imaging><Tissues><Tracer><Training><Tree Shrews><Treeshrews><Tupaiidae><VHH><VHH antibody><Viral><Visualization><Work><Workshop><Writing><X ray microscopy><X-Radiation><X-Ray Imaging><X-Ray Medical Imaging><X-Ray Radiation><X-ray><X-ray microtomography><Xray><Xray imaging><Xray medical imaging><Xray microscopy><Xray microtomography><behavioral disorder><brain research><brain tissue><brain visualization><brain volume><camelid antibody><camelid based antibody><camelid derived antibody><camelid derived fragment><camelid heavy chain only Abs><camelid immunoglobulin><camelid single chain antibody><camelid variable heavy chain><career><career aspiration><career interest><career pathway><career track><cell biology><cell type><comparative><connectome><connectome data><connectomic data><conventional Xray><developmental><graduate student><image-based method><imaging><imaging method><imaging modality><interest><light microscopy><light scattering><mAbs><machine learned algorithm><machine learning algorithm><machine learning based algorithm><materials science><meeting><meetings><member><membrane structure><micro CT><micro computed tomography><microCT><microscope imaging><microscopic imaging><microscopy imaging><microtomography><miniaturize><miniaturized><monoclonal Abs><multi-modal imaging><multi-modality><multi-modality imaging><multimodality><multimodality imaging><multiplexed imaging><nanobodies><nanobody><nanometer resolution><neural><neural circuit><neural circuitry><neural network><neurobiological><neurocircuitry><neuronal><preparations><recruit><resolutions><screening><screenings><sdAb><single domain antibodies><skills><study design><synapse><synaptic circuit><synaptic circuitry><tool><variable heavy chain antibody>
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Min-Jeong Yang

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Exploratory lead · 16/100
Active award
$211,737
FY 2026

Project Title

Mindfulness-based ecological momentary intervention for smoking cessation among cancer survivors

Grant Number:

5R00CA271040-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

12/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Continued tobacco use among cancer survivors is linked to an increased risk of lowered effectiveness of cancer treatment, greater cancer-related mortality, developing a secondary primary cancer, worse quality of life, and increased cancer treatment costs ($3.4 billion/year)....

Research Terms

<Acceptance Process><Active Follow-up><Acute><Address><Affect><Affective><Android App><Android Application><Attention><Awareness><Benchmarking><Best Practice Analysis><Breathing><Cancer Center><Cancer Prevention Intervention><Cancer Survivor><Cancer Survivorship><Cancer Treatment><Cancers><Cell Phone><Cell Phone Application><Cell phone App><Cellular Phone><Cellular Phone App><Cellular Phone Application><Cellular Telephone><Chronic><Client satisfaction><Clinical><Clinical Trials><Cognitive><Data><Development><Distress><Ecological momentary assessment><Effectiveness><Elements><Fatigue><Fear><Feasibility Studies><Feedback><Fright><Future><General Population><General Public><Goals><Guilt><Health><History><Hour><Individual><Intervention><Interview><Knowledge><Lack of Energy><Link><Literature><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Measures><Meditation><Methodology><Mission><Mobile Phones><Nature><Outcome><Pain><Painful><Participant><Patient Satisfaction><Patient Self-Report><Patients><Perception><Persons><Phase><Population><Preparation><Procedures><Process><Psychometrics><QOL><QOL improvement><Qualitative Methods><Quality of life><Randomized><Randomized, Controlled Trials><Recording of previous events><Recurrent Malignant Neoplasm><Recurrent Malignant Tumor><Relapse><Respiratory Aspiration><Respiratory Inspiration><Risk><Risk Factors><Role><Second Cancer><Second Primary Cancers><Secondary Malignancy><Secondary Malignant Neoplasm><Self evaluation><Self-Examination><Self-Report><Self-Surveillance><Shame><Smart Phone App><Smart Phone Application><Smartphone App><Smoke><Smoker><Smoking><Smoking Cessation Intervention><Stress><Structure><Survivors><Testing><Therapeutic><Time><Tobacco><Tobacco Cessation><Tobacco Consumption><Tobacco Use Cessation><Tobacco use><Training><Treatment Cost><Work><acceptability and feasibility><active followup><anti-cancer research><anti-cancer therapy><app on a smartphone><application on a smartphone><arm><barrier to care><barrier to health care><barrier to treatment><benchmark><cancer diagnosis><cancer recurrence><cancer research><cancer therapy><cancer-directed therapy><career><cease smoking><cell phone based app><cost effective intervention><craving><developmental><ecological momentary intervention><efficacy testing><experience><feasibility testing><follow up><follow-up><followed up><followup><handheld mobile device><histories><iOS app><iOS application><iPhone><iPhone App><iPhone Application><improvements in QOL><improvements in quality of life><innovate><innovation><innovative><inspiration><m-Health><mHealth><malignancy><mindfulness><mindfulness intervention><mindfulness-based intervention><mobile device><mobile health><mobile phone app><mortality><negative affect><negative affectivity><neoplasm/cancer><novel><obstacle to care><obstacle to health care><patient barriers><patient-level barriers><phone app><phone application><portability><preparations><primary outcome><prototype><qualitative reasoning><quality of life improvement><quit smoking><randomisation><randomization><randomized control trial><randomly assigned><relapse risk><satisfaction><secondary analysis><secondary cancer><smart phone><smartphone><smartphone application><smartphone based app><smartphone based application><smoking abstinence><smoking cessation><smoking cessation treatment><smoking prevalence><smoking relapse><social role><sound><standard care><standard treatment><stop smoking><temporal measurement><temporal resolution><time measurement><tobacco abstinence><tobacco product use>
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Andrea K Newman

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 16/100
Active award
$198,000
FY 2026

Project Title

Culturally Adapted Pain Management for Indigenous Peoples in the Pacific Northwest (CAP-I)

Grant Number:

4R00MD017254-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2022

End Date:

11/30/2028

Project Abstract

ABSTRACT The prevalence of chronic pain is higher among American Indian/Alaskan Native (AI/AN) people than any other group in the United States. Although a number of psychosocial interventions for chronic pain are well-established as effective, there are no culturally adapted interventions for AI/AN...

Research Terms

<21+ years old><Access to Care><Active Follow-up><Adult><Adult Human><Affect><After Care><After-Treatment><Aftercare><Alabama><Alaska Indian><Alaska Native><Alaska Native group><Alaska Native individual><Alaska Native people><Alaska Native population><Alaska Natives><Alaskan American><Alaskan Indian><Alaskan Native><Alaskan Native American><Alaskan Natives><American><American Indian><American Indian Population><American Indian group><American Indian individual><American Indian people><American Indians><Analgesia Tests><Anxiety><Area><Award><Behavioral><Belief><California><Caring><Clinical><Clinical Trials><Cognition Therapy><Cognitive><Cognitive Psychotherapy><Cognitive Therapy><Cognitive treatment><Communities><Country><Dancing><Data><Development><Education><Educational aspects><Environment><Evaluation><Feedback><Focus Groups><Fostering><Future><Goals><Guidelines><Health Services Accessibility><High Prevalence><Indian Health Service><Indigenous><Indigenous Population><Individual><Intervention><Intervention Studies><Knowledge><Learning><Low income><Manuals><Medical><Medicine><Mental Depression><Mentors><Music><NIH><National Institutes of Health><Native People><Native-Born><Nociception Tests><Non-pharmacologic Therapy><Nonpharmacologic Intervention><Nonpharmacologic Therapy><Nonpharmacologic approach><Nonpharmacologic treatment><Operative Procedures><Operative Surgical Procedures><Opiate Addiction><Opiate Dependence><Pacific Northwest><Pain><Pain Assessment><Pain Control><Pain Measurement><Pain Therapy><Pain intensity><Pain interference><Pain management><Pain measure><Painful><Participant><Pathway interactions><Persons><Phase><Population><Prevalence><Procedures><Process><Psychologist><Public Health><QOL><Quality of life><Randomized><Randomized, Controlled Trials><Reporting><Research><Research Activity><Research Methodology><Research Methods><Research Resources><Resources><Risk><Sampling><Scientist><Sedation procedure><Series><Services><Spirituality><Suicide><Surgical><Surgical Interventions><Surgical Procedure><Survey Instrument><Surveys><Techniques><Testing><Training><Training Activity><Transportation><Tribes><Unemployment><United States><United States Indian Health Service><United States National Institutes of Health><Universities><Washington><Yakama><Yakama Indian><access to health services><access to services><access to treatment><accessibility to health services><active followup><adherence rate><adulthood><availability of services><care access><care as usual><career development><chronic pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><community based design><community based participatory research><community based research><community led research><community participatory research><community partnered participatory research><community partners><community setting><community-based partners><cost><cultural competence><culturally adapted intervention><culturally appropriate intervention><culturally centered intervention><culturally competent><culturally focused intervention><culturally informed intervention><culturally responsive intervention><culturally tailored intervention><depression><determine efficacy><develop therapy><developmental><disability><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><evidence base><examine efficacy><fatal attempt><fatal suicide><feasibility testing><follow up><follow-up><followed up><followup><health service access><health services availability><improved><intent to die><interest><intervention development><intervention research><interventional research><interventional study><interventions research><jobless><joblessness><mindfulness><mindfulness-based stress reduction><non-drug therapy><non-drug treatment><nondrug therapy><nondrug treatment><opioid addiction><opioid dependence><opioid dependent><out of work><pain assay><pain intervention><pain treatment><participatory action research><pathway><peer><pilot trial><post treatment><preference><programs><prototype><psychosocial><public health relevance><randomisation><randomization><randomized control trial><randomly assigned><recruit><research and methods><satisfaction><sedation><service availability><side effect><skill acquisition><skill development><skills><standard of care><suicides><surgery><telehealth><therapy development><training module><treat chronic pain><treatment access><treatment adherence><treatment as usual><treatment compliance><treatment development><tribal community><unemployed><usual care>
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Ilan Cerna-Turoff

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Exploratory lead · 16/100
Active award
$182,936
FY 2026

Project Title

Spatiotemporal effects and associations between deforestation and alcohol and tobacco use in Indonesia

Grant Number:

4R00ES035895-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

11/30/2028

Project Abstract

Deforestation is a critical global issue that leads to extensive macro-level changes in our environment. While past literature has linked sudden or expansive environmental changes to substance use, a knowledge gap exists on how deforestation may influence tobacco and alcohol consumption. The objecti...

Research Terms

<Affect><Agriculture><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohols><Area><Attenuated><Biological Markers><California><Classification><Communities><Complex><Computer software><Consumption><Country><Cross-Sectional Studies><Cross-Sectional Survey><Data><Deforestation><Disease Frequency Surveys><Dose><Drugs><East Indies><Environment><Environmental Epidemiology><Environmental Exposure><Epidemiologist><Epidemiology><EtOH drinking><EtOH use><Exhibits><Face><Factor Analyses><Factor Analysis><Future><General Population><General Public><Generalized Growth><Geography><Goals><Growth><Health><Health Policy><Health behavior><Human><Human Activities><Image><Imagery><Individual><Indonesia><Intervention><Joints><Knowledge><LMIC><Lead><Link><Literature><Malay Archipelago><Medication><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Methods><Mission><Modeling><Modern Man><Morbidity><NIEHS><National Institute of Environmental Health Sciences><Netherlands East Indies><New York City><Outcome><Pattern><Pb element><Pharmaceutical Preparations><Phase><Physiologic><Physiological><Plants><Policies><Population><Probability><Production><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Reproducibility><Research><Research Resources><Resources><Risk><Sight><Software><Strategic Planning><Stress><Stress and Coping><Stressful Event><Subgroup><Systematics><Time><Tissue Growth><Tobacco><Tobacco Consumption><Tobacco use><Training><United States><Vision><Wildfire><alcohol ingestion><alcohol intake><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><attenuate><attenuates><behavioral health><bio-markers><biologic marker><biological adaptation to stress><biomarker><career><coping with stress><cost><cross-sectional research study><design><designing><drug/agent><economic incentive><environmental change><epidemiologic><epidemiological><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><experience><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><faces><facial><forest><forest clearing><health care policy><health related behavior><heavy metal Pb><heavy metal lead><imaging><improved><low and middle-income countries><mental illness><mortality><ontogeny><palm oil><palmolein><participatory sensing><population health><psychiatric illness><psychological disorder><reactioncrisis><remote sensing><response><simulation><social><spatial and temporal><spatial temporal><spatiotemporal><stress response><stress-related coping><stressreaction><stressful experience><stressful life event><stressful life experience><substance use><substance using><tobacco product use><trend><visual function><wild fire><wildland fire>
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Nicholas J Audette

UNIVERSITY OF CONNECTICUT STORRS, STORRS-MANSFIELD, CT

Exploratory lead · 16/100
Active award
$180,778
FY 2026

Project Title

To identify mechanisms of predictive processing across the distributed thalamocortical circuit

Grant Number:

5R00DC020770-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/16/2023

End Date:

12/31/2027

Project Abstract

Project Summary Many of the sounds that animals hear are created by their own actions and being able to correctly differentiate these sounds is critical to a range of behaviors. An influential idea is that the brain uses sensory-motor predictions to anticipate sounds generated by movement, and ident...

Research Terms

<Acoustics><Animals><Area><Auditory><Auditory Cortex><Auditory area><Augmented Reality><Axon><Behavior><Behavioral><Brain><Brain Nervous System><Brain region><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Communication><Computational Technique><Data><Disease><Disorder><Dysfunction><Electrophysiology><Electrophysiology (science)><Elements><Encephalon><Environment><Forelimb><Functional disorder><Funding><Goals><Head><Health><Hearing><Home><Individual><Influentials><Intervention><Intracellular Communication and Signaling><Knowledge><Label><Learning><Link><Location><Maps><Mentors><Mentorship><Mice><Mice Mammals><Modeling><Motor><Motor Cortex><Movement><Murine><Mus><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neurocyte><Neuronal Transmission><Neurons><Neurophysiology / Electrophysiology><New York><Optics><Outcome><Pathway interactions><Pattern><Physiologic><Physiological><Physiopathology><Play><Position><Positioning Attribute><Research Resources><Resources><Scientist><Sensory><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Synapses><Synaptic><Technology><Testing><Thalamic structure><Thalamus><Tracer><Training><Transgenic Mice><Translating><Transmission><Universities><Work><auditory processing><auditory thalamus><axon signaling><axon-glial signaling><axonal signaling><behavior prediction><behavioral prediction><biological signal transduction><body movement><career><electrophysiological><expectation><experience><experiment><experimental research><experimental study><experiments><flexibility><flexible><glia signaling><glial signaling><homes><insight><nerve signaling><neural><neural signaling><neuronal><neuronal signaling><neurotransmission><optical><optogenetics><patch clamp><pathophysiology><pathway><sensory cortex><sensory input><sensory integration><skills><sound><synapse><thalamic><transmission process><wireless>
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Benjamin Ross Freedman

BETH ISRAEL DEACONESS MEDICAL CENTER, BOSTON, MA

Exploratory lead · 16/100
Active award
$121,030
FY 2026

Project Title

Supplement Multifunctional Tough Adhesive Hydrogels to Recruit, Expand, and Deliver Tendon Cells During Aging and Injury

Grant Number:

3R00AG065495-05S1

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2020

End Date:

5/31/2027

Project Abstract

Project Summary/Abstract My laboratory studies structure-function mechanisms of tendon aging and injury and how they may be improved using biomaterials. My research training in bioengineering started by studying the role of healing and fatigue loading on multiscale tendon properties. I realized that...

Research Terms

<Acute><Adhesives><Aging><Autoregulation><Biocompatible Materials><Biology><Biology of Aging><Biomaterials><Biomedical Engineering><Body Tissues><Calcanean Tendon><Cell Body><Cells><Cellular Expansion><Cellular Growth><Chronic><Connective Tissue Diseases><Connective Tissue Disorder><Development><Disease><Disorder><Drug Delivery><Drug Delivery Systems><Dysfunction><Environment><Fatigue><Fiber><Functional disorder><Goals><Homeostasis><Hydrogels><In Vitro><Incidence><Individual><Infiltration><Injury><Investigators><Knowledge><Laboratory Study><Lack of Energy><Mechanics><Mentors><Mucous body substance><Mucus><Musculoskeletal><Natural regeneration><Orthopedic><Orthopedic Surgery><Orthopedic Surgical Profession><Orthopedics><Physiological Homeostasis><Physiopathology><Proliferating><Property><Recreation><Regeneration><Research><Research Personnel><Research Training><Researchers><Rodent Model><Role><Scientist><Site><Sports><Structure><Supporting Cell><Surface><System><Tendon Injuries><Tendon structure><Tendons><Testing><Therapeutic><Tissues><Training><achilles tendon><age associated><age correlated><age dependent><age linked><age related><age specific><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><aging population><bio-engineered><bio-engineers><bioengineering><biological engineering><biological material><cell growth><clinical relevance><clinically relevant><developmental><healing><improved><in vivo><injuries><materials science><mechanic><mechanical><mucous><pathophysiology><population aging><post-doctoral training><programs><recruit><regenerate><scaffold><scaffolding><skills><slug><social role><success>
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Christina B Young

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Exploratory lead · 16/100
Active award
$112,700
FY 2026

Project Title

Regional tau deposition and digital assessment of cognition in preclinical AD and MCI

Grant Number:

3R00AG071837-03S1

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2022

End Date:

8/31/2028

Project Abstract

PROJECT SUMMARY The applicant seeks this Administrative Supplement in relation to her R00 award, which examines the association between regional tau deposition and domain-specific cognitive decline given that pathological and clinical evidence of Alzheimer’s disease converges to suggest that both ep...

Research Terms

<AD and related dementia><AD dementia><AD related dementia><ADRD><Address><Administrative Supplement><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's amyloid><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's diagnosis><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease diagnosis><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Amentia><Amyloid><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Android App><Android Application><Applications Grants><Area><Award><Aβ><Brain><Brain Nervous System><Brain region><Cell Phone><Cell Phone Application><Cell phone App><Cellular Phone><Cellular Phone App><Cellular Phone Application><Cellular Telephone><Clinical><Clinical Trials><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive Manifestations><Cognitive Symptoms><Cognitive decline><Cognitive function abnormal><Data><Data Collection><Dementia><Deposit><Deposition><Development><Digital biomarker><Disturbance in cognition><Early Diagnosis><Encephalon><Ensure><Episodic memory><Event><Future><General Radiology><Goals><Grant Proposals><Impaired cognition><Individual><Institution><Knowledge><Language><Length><Life><Location><MT-bound tau><Measures><Memory Loss><Mentors><Mentorship><Mobile Phones><Monitor><Moods><Multimodal Imaging><Neuritic Plaques><Neurology><Neuropsychologic Tests><Neuropsychological Tests><Neuropsychologies><Neuropsychology><PET><PET Scan><PET imaging><PETSCAN><PETT><Participant><Pathologic><Persons><Phase><Position><Positioning Attribute><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Primary Senile Degenerative Dementia><Publications><R-Series Research Projects><R01 Mechanism><R01 Program><Rad.-PET><Radiology><Radiology Specialty><Research><Research Grants><Research Project Grants><Research Projects><Risk><Scientific Publication><Semantic memory><Senile Plaques><Sensitivity and Specificity><Smart Phone App><Smart Phone Application><Smartphone App><Speech><Structure><Tau forming aggregates><Testing><Time><Training><Voice><a beta peptide><abeta><abnormally aggregated tau protein><aggregation in tau><amyloid beta><amyloid beta plaque><amyloid-b plaque><amyloid-b protein><app on a smartphone><application on a smartphone><aβ plaques><beta amyloid fibril><career><cell phone based app><cognitive assessment><cognitive dysfunction><cognitive function><cognitive loss><cognitive performance><cognitive testing><cohort><cored plaque><dementia risk><design><designing><developmental><diffuse plaque><digital assessment><digital marker><early detection><filamentous tau inclusion><high risk><iOS app><iOS application><iPhone><iPhone App><iPhone Application><imaging biomarker><imaging marker><imaging-based biological marker><imaging-based biomarker><imaging-based marker><improved><in vivo><innovate><innovation><innovative><longitudinal design><longitudinal experimental design><longitudinal research design><longitudinal study design><medial temporal area><medial temporal lobe><memory decline><mesial temporal area><mesial temporal lobe><microtubule associated protein tau aggregation><microtubule associated protein tau deposit><microtubule bound tau><microtubule-bound tau><mid life><mid-life><middle age><middle aged><midlife><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><mobile phone app><multi-modal imaging><multi-modality imaging><multimodality imaging><neuropsychologic><novel><older adult><older adulthood><paired helical filament of tau><parent award><parent project><phone app><phone application><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical><preclinical><primary degenerative dementia><professor><programs><psychiatric symptom><response><response to therapy><response to treatment><risk factor for dementia><risk for dementia><screening><screenings><self-aggregate tau><senile dementia of the Alzheimer type><smart phone><smartphone><smartphone application><smartphone based app><smartphone based application><soluble amyloid precursor protein><tau><tau PHF><tau Proteins><tau accumulation><tau aggregate><tau aggregation><tau factor><tau fibrillation><tau fibrillization><tau filament><tau inclusion><tau neurofibrillary tangle><tau oligomer><tau paired helical filament><tau polymerization><tau protein accumulation><tau protein aggregation><tau-tau interaction><tenure process><tenure track><therapeutic response><therapy response><treatment response><treatment responsiveness><verbal><τ Proteins><τ aggregation>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jennifer Vanessa Chavez

FLORIDA INTERNATIONAL UNIVERSITY, MIAMI, FL

Exploratory lead · 16/100
Active award
$45,516
FY 2026

Project Title

Probing the Proteome: Depressive Symptoms, Inflammation and Mitochondrial Perturbations in Acute HIV Infection

Grant Number:

5R36MH139364-02

Activity Code:

R36

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2024

End Date:

11/30/2026

Project Abstract

PROJECT SUMMARY The primary objective of the proposed R36 is to elucidate molecular mechanisms whereby inflammation and mitochondrial dysfunction, both in the presence and absence of amphetamine-type stimulant use during acute HIV infection, can predict persistent depressive symptoms over 96 weeks o...

Research Terms

<(TNF)-α><AIDS Virus><AIDS care><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Active Oxygen><Acute><Amphetamines><Anhedonia><Antioxidants><Apoptosis><Apoptosis Pathway><Assay><BBB crossing><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Bioassay><Biological><Biological Assay><Biological Markers><Blood Plasma><Blood Serum><Brain><Brain Nervous System><C-reactive protein><CD 120a Antigen><CD120a Antigens><CNS Nervous System><Cachectin><Calcium><Cell Membrane Permeability><Central Nervous System><Characteristics><Chronic><Clinical><Cohort Studies><Collaborations><Conditioning Therapy><Continuity of Care><Continuity of Patient Care><Continuum of Care><Corpus Striatum><Corpus striatum structure><DNA><Data><Deoxyribonucleic Acid><Depressive Syndromes><Depressive disorder><Desoxynorephedrin><Detection><Development><Disease><Disorder><Dopamine><Drug Therapy><Dysfunction><Electron Transport><Emotional><Emotional Depression><Encephalon><Exhibits><Extracellular Signal-Regulated Kinase Gene><Feedback><Functional disorder><Functional impairment><Future><General Population><General Public><Glutamates><Glutathione><Goals><Gut associated lymphoid tissue><HIV><HIV Antibodies><HIV Care><HIV Infections><HIV individuals><HIV infected individuals><HIV infected persons><HIV load><HIV medical care><HIV patient care><HIV people><HIV plasma viral load><HIV positive individuals><HIV positive people><HIV related care><HIV related patient care><HIV viral burden><HIV viral infection><HIV viral load><HIV virus infection><HIV-1 care><HIV-1 infection><HIV-1 load><HIV-1 viral burden><HIV-1 viral load><HIV-Associated Antibodies><HPA axis><HTLV-III Antibodies><HTLV-III-LAV Antibodies><Hortega cell><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Antibodies><Hydroxytyramine><IQ Deficit><Immune><Immune Cell Activation><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immunes><Immunoglobulin Enhancer-Binding Protein><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Individual><Infection><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Inflammasome><Inflammation><Inflammatory><Intermediary Metabolism><L-Glutamate><LAV Antibodies><LAV-HTLV-III><Link><Lymphadenopathy-Associated Antibodies><Lymphadenopathy-Associated Virus><MAP Kinase Gene><MAPK><Macrophage><Macrophage-Derived TNF><Mental Depression><Mental Health><Mental Hygiene><Mentorship><Metabolic Processes><Metabolism><Microglia><Mitochondria><Mitochondrial DNA><Mitogen-Activated Protein Kinase Gene><Molecular><Monocyte-Derived TNF><Mφ><NF-kB><NF-kappa B><NF-kappaB><NFKB><Nerve Transmitter Substances><Neuraxis><Neurocognitive><Neurocognitive Deficit><Neuroimmune><Neuroimmune Mechanisms><Neuroimmune Processes><Neuroimmunomodulation><Neurotransmitters><Nuclear Factor kappa B><Nuclear Transcription Factor NF-kB><Oxidative Stress><Oxygen Radicals><PLWH><PWH><Participant><Pathogenesis><Pathway interactions><Peripheral><Persons><Pharmacological Treatment><Pharmacotherapy><Phenamine><Phenopromin><Physiopathology><Plasma><Plasma Serum><Prediction of Response to Therapy><Pro-Oxidants><Process><Programmed Cell Death><Proteins><Proteins, specific or class, C-reactive><Proteome><Proteomics><Psychological Health><Reactive Oxygen Species><Research><Reticuloendothelial System, Serum, Plasma><Risk><Sampling><Serum><Stress><Striate Body><Striatum><Symptoms><System><T-Cells><T-Lymphocyte><TNF><TNF A><TNF Alpha><TNF Receptor p55><TNF gene><TNF-sR55><TNF-α><TNF-α receptor><TNFA><TNFAR><TNFR p60><TNFR, 55-kD><TNFR, 60-kD><TNFR-I><TNFR1><TNFR55><TNFR60><TNFRSF1A><TNFRSF1A Receptor><TNFRSF1A gene><TNFalpha receptor><TNFα><TNFα receptor><Technology><Transcription Factor NF-kB><Tumor Necrosis Factor><Tumor Necrosis Factor Receptor 1><Tumor Necrosis Factor Receptor 55><Tumor Necrosis Factor-alpha><Viral Burden><Viral Load><Viral Load result><Virus-HIV><Visit><acute symptom><amphetamine use><antiretroviral therapy><antiretroviral treatment><aptamer><behavior intervention><behavioral intervention><bio-markers><biobehavior><biobehavioral><biologic><biologic marker><biological adaptation to stress><biomarker><blood-brain barrier crossing><bloodbrain barrier crossing><care of HIV-1><clinical phenotype><co-morbid><co-morbidity><cohort><cohort research study><cohort survey><comorbidity><cytokine><depression><depression symptom><depressive><depressive symptoms><developmental><differential expression><differentially expressed><dl-Amphetamine><drug intervention><drug treatment><electron transfer><exhaustion><gamma-L-Glu-L-Cys-Gly><gamma-L-Glutamyl-L-Cysteinylglycine><gitter cell><glutamatergic><human immunodeficiency virus care><human immunodeficiency virus infection><hypothalamic-pituitary-adrenal (HPA) axis><hypothalamic-pituitary-adrenal axis><hypothalmus-pituitary-adrenal axis><immune activation><immune reconstitution><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infected with HIV><infected with human immunodeficiency virus><intelligence quotient deficit><investigate longitudinal><investigate prospective><kappa B Enhancer Binding Protein><longitudinal investigation><longitudinal research><membrane permeability><mesoglia><microbial><microglial cell><microgliocyte><mitochondrial><mitochondrial dysfunction><mitochondrial membrane><mtDNA><neural inflammation><neurocognitive decline><neurocognitive impairment><neuroinflammation><neuroinflammatory><neuropsychiatric><neuropsychiatry><novel><nuclear factor kappa beta><pathophysiology><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><perivascular glial cell><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><poor health outcome><predict therapeutic response><predict therapy response><prospective investigation><prospective research><protein expression><proteomic signature><psychostimulant use><reactioncrisis><reduced health outcome><response><stimulant use><stress response><stress symptom><stressreaction><striatal><study longitudinal><study prospective><substance use><substance using><survey longitudinal><survey prospective><systemic inflammation><systemic inflammatory response><therapy prediction><thymus derived lymphocyte><transcriptional differences><treatment prediction><treatment response prediction><tumor necrosis factor alpha receptor><tumor necrosis factor receptor 1A><tumor necrosis factor α receptor><use of stimulants><worse health outcome>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Rebecca Schwarzlose

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 16/100
Active award
$6,162
FY 2026

Project Title

Neural mechanisms of sensory over-responsivity in children with and without ASD

Grant Number:

3R00HD109454-04S1

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2024

End Date:

8/31/2027

Project Abstract

PROJECT ABSTRACT Sensory over-responsivity (SOR), or strong negative reactions to and avoidance of innocuous sensory stimuli, affects about one in five school-age children and about two-thirds of children with autism spectrum disorder (ASD) and several other common neurodevelopmental disorders. Chil...

Research Terms

<0-11 years old><ASD><Affect><Anxiety><Anxiety Disorders><Area><Attenuated><Auditory><Auditory Cortex><Auditory area><Autism><Autistic Disorder><Award><Basic Research><Basic Science><Brain><Brain Nervous System><Causality><Cell Communication and Signaling><Cell Signaling><Child><Child Youth><Childhood><Children (0-21)><Clinical><Committee Members><Communities><Data><Data Set><Development><Diagnosis><Distress><Early Infantile Autism><Encephalon><Etiology><Event><Exhibits><Family><Fear><Fright><Functional MRI><Functional Magnetic Resonance Imaging><Functional impairment><Future><Goals><Health><Impairment><Infantile Autism><Institution><Intervention><Intracellular Communication and Signaling><Investigators><Kanner's Syndrome><Knowledge><Learning><Location><Measurable><Measurement><Measures><Mental disorders><Mental health disorders><Mentors><Neurodevelopmental Disorder><Neurological Development Disorder><Neurosciences Research><Noise><Nutrition><Pathway interactions><Personal Satisfaction><Phase><Prevalence><Psychiatric Disease><Psychiatric Disorder><Psychopathology><Reaction><Research><Research Personnel><Researchers><Rest><Risk><Running><Scanning><School-Age Population><Scientific Advances and Accomplishments><Scientist><Sensory><Signal Transduction><Signal Transduction Systems><Signaling><Site><Social isolation><Standardization><Stimulus><Symptoms><Tactile><Techniques><Testing><Training><Work><abnormal psychology><attenuate><attenuates><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic children><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><base><bases><biological signal transduction><career><causation><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><complex data><cost><developmental><disease causation><effective intervention><experience><fMRI><fMRI scan><functional MRI scan><functional magnetic resonance imaging scan><improved><innovate><innovation><innovative><insight><kids><mental illness><methods to study multiple-level influences><multi-level analysis><multi-level model><multilevel analysis><multilevel model><multilevel modeling><neural><neural adaptation><neural correlate><neural mechanism><neuroadaptation><neurodevelopmental disease><neuromechanism><new approaches><novel><novel approaches><novel strategies><novel strategy><pathway><pediatric><peer><perceptual stimulus><physicochemical phenomena related to the senses><poor sleep><psychiatric illness><psychological disorder><recruit><response><school age><scientific accomplishments><scientific advances><sensory mechanism><sensory neuroscience><sensory stimulus><skills><social><success><tool><translation strategy><translational approach><translational strategy><well-being><wellbeing><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Search NIH grants by PI name

Looking for a specific principal investigator? The keyword search above looks up funded projects by topic. To search NIH grants by PI name (last name, first + last name, or partial name) and see every active and recent NIH award for that researcher, use the dedicated PI Funding Status tool.

How to Use PI Funding Data for Career Decisions

Finding the right principal investigator is one of the most important decisions in an academic career. Whether you are a postdoc looking for a mentor, a graduate student choosing a rotation lab, or a collaborator seeking a co-PI, NIH funding data provides objective signals about which investigators have active research programs and resources to support new team members.

A PI with a recently awarded R01 or equivalent grant is more likely to have budget for new personnel than one whose funding ended two years ago. The activity code tells you the type of grant: R01 and R35 awards typically support multiple lab members, while K-series awards are individual career development grants that may not fund additional positions. Understanding these distinctions helps you interpret search results accurately.

Look beyond the dollar amount. A $500,000 per year R01 at a high-cost institution may support fewer positions than a $300,000 award at a university with lower overhead rates. The project abstract and public health relevance statement reveal whether the PI's research direction aligns with your interests and expertise.

Understanding PI Grant Portfolios

A PI's grant portfolio reveals more than individual awards. Investigators with multiple active grants often run larger labs with more diverse projects, which can mean more opportunities for trainees. However, a PI with a single well-funded grant may offer more focused mentorship and a clearer path to publications.

Multi-PI grants (those with more than one principal investigator listed) indicate collaborative research and may involve trainees from multiple institutions. These can be excellent opportunities for interdisciplinary training but may also mean split attention from any single mentor.

Pay attention to the timing of awards. A PI who just received a new five-year R01 is in a different position than one whose grant ends next year. New awards often correspond to lab expansion and active recruiting, making them ideal targets for job seekers. The start and end dates shown in each result help you assess this timing.

Best Practices for Contacting Funded PIs

Once you identify a promising PI through this tool, the next step is outreach. NIH public records do not include email addresses, but you can usually find contact information through the PI's institutional profile page, lab website, or recent publications. Google Scholar, PubMed, and the PI's department website are reliable starting points.

When reaching out, reference the specific grant that caught your attention. Mentioning the project title and explaining how your skills relate to the funded work shows that you have done your homework. Keep your initial message concise: introduce yourself, explain your interest, attach your CV, and ask whether they anticipate openings.

Timing matters. Contacting a PI within the first year of a new award is ideal, as this is when they are most likely to be recruiting. If you find multiple promising PIs in the same field, prioritize those with the most recent award notices and activity codes that support trainee positions such as R01, U01, or P-series grants.

Frequently Asked Questions About PI Search

What does the opportunity score mean?

The opportunity score is a heuristic that combines award recency, funding amount, activity code type, and project characteristics to estimate how actionable a result might be for job seekers or collaborators. Higher scores suggest stronger signals, but always verify by reading the abstract and checking the PI's current lab page.

Why can't I find a PI I know has funding?

Name variations are the most common cause. Try searching with just the last name, or use different formats like "Smith, John" versus "John Smith." Some PIs also publish under different name variations or may have awards under a previous institutional affiliation.

Does this tool show all NIH-funded PIs?

The tool searches NIH RePORTER data for the keyword and year range you specify. It returns PIs whose funded projects match your search terms. PIs with grants in unrelated areas or whose projects use different terminology will not appear in keyword-filtered results.

What is the difference between "Likely hiring" and "Training-friendly" filters?

"Likely hiring" flags PIs with large new awards or activity codes typically associated with lab expansion. "Training-friendly" identifies awards that include training components or are at institutions known for postdoctoral programs. Both are heuristic filters to help prioritize your outreach.

How to use this well

Start broad, then narrow. Search a field first, then refine by timeframe once you understand who is currently active.

After you find a promising PI, cross-check them in Check PI Funding and review their institution, mechanism type, and project abstracts before reaching out.

What a match means

A result means the keyword appears relevant to the funded project data we searched. It does not guarantee the PI is hiring or that the grant is still active.

Use the abstract, award year, mechanism, and organization context to decide whether the record is strategically relevant.

Data limits

NIH records can lag, institutional names can vary, and some investigators publish or file awards under multiple name formats.

For details on source coverage and refresh cadence, read Data & Methodology.

Related guides

Companion guides for turning a PI search result into useful outreach or a job lead.

Career Guide8 min read

How Postdocs Can Find PIs with New NIH Funding

A tactical job-search guide for identifying recently funded labs, judging fit, and timing outreach to principal investigators.

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Career Guide7 min read

How to Contact a PI: Finding Emails and Crafting the Perfect Message

Emailing strategies, outreach examples, and a workflow for turning NIH funding signals into focused PI conversations.

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Career Guide10 min read

How to Read a New NIH Award Like a Hiring Signal

A practical framework for using newly funded NIH awards to judge whether a lab may be expanding, hiring, or worth contacting now.

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Funding Strategy16 min read

How to Find NIH Funding Opportunities: A Step-by-Step Guide for Researchers

Learn how to find NIH funding opportunities using the NIH Guide, Grants.gov, FOAs, NIH RePORTER, and program officer outreach.

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Recently Funded Labs in Trending Areas

Principal investigators who received NIH awards in the last 90 days, organized by research area. Use this as a starting point for postdoc searches, collaborator outreach, or competitor scans. Counts and labs refresh daily.

Alzheimer's disease

Neurodegeneration, biomarkers, and disease-modifying therapies.

  • Carlos Cruchaga — WASHINGTON UNIVERSITY, MO
    CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
    $101,153 · awarded Feb 25, 2026 · 3U01AG084514-01A1S1
  • Carlos Cruchaga — WASHINGTON UNIVERSITY, MO
    CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
    $3,086,339 · awarded Feb 19, 2026 · 1U01AG084514-01A1
  • HARALD SONTHEIMER — UNIVERSITY OF VIRGINIA, VA
    Extracellular matrix and memory impairments in Alzheimer disease
    $709,066 · awarded Apr 7, 2026 · 5R01AG085359-03
  • Keith Josephs — MAYO CLINIC ROCHESTER, MN
    The neurobiology of two distinct subtypes of neurodegenerative apraxia of speech: phenotypes of Alzheimer disease related 4-repeat tauopathies
    $643,670 · awarded Apr 1, 2026 · 5R01DC014942-09
  • DMITRIY YABLONSKIY — WASHINGTON UNIVERSITY, MO
    Deep-Learning-Augmented Quantitative Gradient Recalled Echo (DLA-qGRE) MRI for in vivo Clinical Evaluation of Brain Microstructural Neurodegeneration in Alzheimer Disease
    $661,985 · awarded Mar 3, 2026 · 4R01AG082030-02
Search more PIs in Alzheimer's disease →

CRISPR & gene editing

Therapeutic gene editing, base editing, and prime editing.

  • Changchun Liu — UNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT
    Asymmetric CRISPR Approach for Nucleic Acid Quantification
    $643,849 · awarded Mar 30, 2026 · 2R01EB023607-06A1
  • William Pu — BOSTON CHILDREN'S HOSPITAL, MA
    A modular system for murine CRISPR genome and epigenome editing
    $267,000 · awarded Mar 27, 2026 · 5R21OD037909-02
  • Naama Aviram — SLOAN-KETTERING INST CAN RESEARCH, NY
    Molecular mechanisms of memory formation and tolerance in CRISPR-Cas systems
    $249,000 · awarded Apr 2, 2026 · 5R00GM148720-04
  • Mats Ljungman — UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI
    Precision targeting of bladder cancer using CRISPR
    $582,849 · awarded Feb 17, 2026 · 5R01CA285730-03
  • Shannon Miller — SCRIPPS RESEARCH INSTITUTE, THE, CA
    Development of potent and safe CRISPR tools for in vivo gene editing using directed evolution
    $230,000 · awarded May 5, 2026 · 5R21EB036298-03
Search more PIs in CRISPR & gene editing →

Cancer immunotherapy

Checkpoint inhibitors, CAR-T, TIL therapy, and beyond.

  • TERRY SHEPPARD — KEYSTONE SYMPOSIA, CO
    Cancer Immunotherapy: Basic Mechanisms Informing Clinical Applications & Combinations
    $5,000 · awarded Mar 3, 2026 · 1R13CA310704-01
  • Veronika Fedirko — UNIVERSITY OF TX MD ANDERSON CAN CTR, TX
    Gut Microbiome and Cancer Immunotherapy Outcomes in Advanced Renal Cell Carcinoma
    $927,329 · awarded Mar 3, 2026 · 5R01CA255322-05
  • Yuwen Zhu — UNIVERSITY OF COLORADO DENVER, CO
    The GPR171 pathway in cancer immunotherapy
    $355,706 · awarded Apr 2, 2026 · 5R01CA279398-04
  • ANDREW WIEMER — UNIVERSITY OF CONNECTICUT STORRS, CT
    Synthesis and evaluation of BTN3A1 ligands for cancer immunotherapy
    $374,171 · awarded May 1, 2026 · 5R01CA266138-05
  • Wei Hu — YALE UNIVERSITY, CT
    Novel Treg inactivating approach for cancer immunotherapy via targeted protein degradation
    $482,312 · awarded Apr 6, 2026 · 1R01CA295942-01A1
Search more PIs in Cancer immunotherapy →

GLP-1 & metabolic disease

Diabetes, obesity, and weight-loss therapeutic mechanisms.

  • ZHIPING PANG — RUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ
    Synaptic and circuit mechanisms of central GLP-1 signaling in energy balance
    $479,051 · awarded Apr 23, 2026 · 5R01DK131452-05
  • Madhusmita Misra — UNIVERSITY OF VIRGINIA, VA
    Bone metabolism in adolescents undergoing GLP-1 receptor agonist therapy
    $471,776 · awarded Apr 24, 2026 · 5R01HD118635-07
  • STEVEN SCHWENDEMAN — UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI
    Remote Loading of Melanocortin and GLP-1 Peptides in Polymers for Treatment of Obesity
    $231,000 · awarded Apr 17, 2026 · 1R56DK141545-01A1
  • Jessica Barson — DREXEL UNIVERSITY, PA
    Suppression of ethanol dependence-induced maladaptive appetitive and consummatory behavior by the GLP-1 system
    $564,306 · awarded May 5, 2026 · 1R01AA031732-01A1
  • MICHAEL CAMILLERI — MAYO CLINIC ROCHESTER, MN
    A Randomized, placebo-controlled trial of the effects of Long-Acting GLP-1 or Dual Incretin (GLP-1 and GIP) Modulation on Gastrointestinal Functions and Relationship to Weight Loss
    $322,800 · awarded Apr 9, 2026 · 5R01DK142606-02
Search more PIs in GLP-1 & metabolic disease →

Long COVID

Post-acute sequelae and chronic infection-driven illness.

  • Alexei Tumanov — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX
    Lymphotoxin-dependent control of long COVID
    $234,715 · awarded Feb 13, 2026 · 1R21AI185790-01A1
  • Amal Amer — OHIO STATE UNIVERSITY, OH
    Role of the Non-canonical Inflammasome in SARS-CoV-2-mediated Pathology and Coagulopathy
    $2,974,582 · awarded Apr 21, 2026 · 5P01AI175399-03
  • Alba Azola — JOHNS HOPKINS UNIVERSITY, MD
    Blood-Brain Barrier Integrity and Immune Dynamics in Neuropsychiatric Sequelae of Post-SARS-CoV-2 onset ME/CFS versus Pre-Pandemic ME/CFS Patients
    $633,378 · awarded Apr 17, 2026 · 1R01NS147100-01
  • DANIELLE REED — MONELL CHEMICAL SENSES CENTER, PA
    Inflammation and chemosensory loss
    $2,654,249 · awarded Feb 26, 2026 · 1P50DC022549-01A1
  • Jarred Younger — UNIVERSITY OF ALABAMA AT BIRMINGHAM, AL
    Low-dose naltrexone (LDN) for the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
    $556,686 · awarded Mar 6, 2026 · 1UG3NS141843-01A1
Search more PIs in Long COVID →