NIH RFA · RMOD · UM1
RFA-RM-27-016: Cellular Senescence Network (SenNet): Discovery, Validation Centers (UM1 Clinical Trials Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of this Notice of Funding Opportunity (NOFO) is to support SenNet Discovery and Validation Centers (SenNet DVCs) as a core component of Stage 2 of the NIH Common Fund Cellular Senescence Network (SenNet). Building on Stage 1 resources, DVCs will define, refine, and validate tissue- and disease-relevant cellular senescence signatures (“senotypes”) and associated biomarkers, and will investigate their functional consequences in human health and disease. DVCs are expected to generate and contribute high-quality molecular, cellular, and spatial datasets (including relevant metadata and documentation) and to use complementary experimental systems, as appropriate, to validate…
- NOFO number
- RFA-RM-27-016
- Type
- RFA
- Activity code
- UM1
- Primary institute
- RMOD
- Clinical trials
- Not Allowed
- Posted
- Oct 9, 2026
- Opens
- Oct 23, 2026
- Expires
- Nov 24, 2026
RFA-RM-27-016 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| November 23, 2026 | Not Applicable | Not Applicable | March 2027 | May 2027 | July 2027 |
Funded projects
NIH RePORTER lists no awards under RFA-RM-27-016 in FY2022–FY2026, and it is a new NOFO rather than a reissue. Awards usually appear a few months after the first review cycle.
Participating institutes
4 NIH institutes and offices take applications under RFA-RM-27-016. Contact the program officer at the institute that fits your research before applying.
- RMOD
- NOFO
- NIA · National Institute on Aging
- none
Related notices
NIH lists no related notices for RFA-RM-27-016 yet.
Award terms
- Application types allowed
- New The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are limited to approximately 3M per year in direct cost but need to reflect the actual needs of the proposed project.The budget for the organizational component should approximately be 600,000 in direct cost per year.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- NIH Common Fund Office of Strategic Coordination) intends to fund 5-6 DVC awards corresponding to a total of 24M per year for fiscal years 2027-2032. Future year amounts will depend on annual appropriations.Only 1SenNet Organization and Outreach Component SOOC) will be awarded among the DVC and DCIC awards this and companion DCIC NOFO).
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Companion NOFOs: RFA-RM-27-007, RFA-RM-27-025.
Other open NOFOs for UM1
- RFA-RM-27-025Cellular Senescence Network (SenNet): SenNet Data Coordination and Integration Center (SenNet DCIC) (UM1 Clinical Trials Not Allowed)RMOD · next due Nov 23, 2026
- RFA-AI-27-002Infectious Diseases Clinical Trials Network (IDCTN) (UM1 Clinical Trial Required)NIAID · next due Nov 10, 2026
- RFA-AI-27-005Clinical Research Network on Antimicrobial Resistance (UM1 Clinical Trial Required)NIAID · next due Nov 10, 2026
- RFA-HG-27-007Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)NHGRI · next due Dec 14, 2026
- RFA-HG-27-009Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)NHGRI · next due Dec 14, 2026
- RFA-HG-27-010Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed)NHGRI · next due Dec 14, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.