NIH RFA · NHGRI · UM1
RFA-HG-27-009: Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to study the effects of genetic or environmental interactions on genomic variant impact. To accomplish this, interaction centers will first propose a research framework to investigate whether interactions with effects beyond additive are important modifiers of the impact of variants. Centers will apply their framework to experimentally test combinations for interactions and share their data as well as analyses through the Impact of Genomic Variation on Function (IGVF) portal and catalog. Centers will share their method for predicting the most important combinations for future testing. The rationale for this…
- NOFO number
- RFA-HG-27-009
- Type
- RFA
- Activity code
- UM1
- Primary institute
- NHGRI · National Human Genome Research Institute
- Clinical trials
- Not Allowed
- Posted
- Oct 9, 2026
- Opens
- Nov 14, 2026
- Expires
- Dec 15, 2026
RFA-HG-27-009 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| December 14, 2026 | Not Applicable | Not Applicable | July 2027 | August 2027 | September 2027 |
Funded projects
NIH RePORTER lists no awards under RFA-HG-27-009 in FY2022–FY2026, and it is a new NOFO rather than a reissue. Awards usually appear a few months after the first review cycle.
Participating institutes
2 NIH institutes and offices take applications under RFA-HG-27-009. Contact the program officer at the institute that fits your research before applying.
- NHGRI · National Human Genome Research Institute
- none
Related notices
NIH lists no related notices for RFA-HG-27-009 yet.
Award terms
- Application types allowed
- New The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets must not exceed 1.5M direct costs per year. Application costs must reflect the actual needs of the proposed project.
- Project period
- The maximum project period is five years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- NHGRI intends to commit 10M total costs in FY 2027 to fund 5 awards.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Companion NOFOs: RFA-HG-27-007, RFA-HG-27-008, RFA-HG-27-010.
Other open NOFOs for UM1
- RFA-HG-27-007Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)NHGRI · next due Dec 14, 2026
- RFA-HG-27-010Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed)NHGRI · next due Dec 14, 2026
- RFA-AI-27-002Infectious Diseases Clinical Trials Network (IDCTN) (UM1 Clinical Trial Required)NIAID · next due Nov 10, 2026
- RFA-AI-27-005Clinical Research Network on Antimicrobial Resistance (UM1 Clinical Trial Required)NIAID · next due Nov 10, 2026
- RFA-RM-27-016Cellular Senescence Network (SenNet): Discovery, Validation Centers (UM1 Clinical Trials Not Allowed)RMOD · next due Nov 23, 2026
- RFA-RM-27-025Cellular Senescence Network (SenNet): SenNet Data Coordination and Integration Center (SenNet DCIC) (UM1 Clinical Trials Not Allowed)RMOD · next due Nov 23, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.