NIH RFA · NIAID · UM1
RFA-AI-28-005: Immune Tolerance Network (UM1 Clinical Trial Required)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 26, 2026Editorial standards
The purpose of this notice of funding opportunity (NOFO) is to support applications to continue the Immune Tolerance Network (ITN). The primary objective of the Network is to develop tolerogenic therapies for immune-mediated disorders. The three main clinical areas of work are: 1) Allergic diseases and asthma; 2) Autoimmune diseases; and 3) Immune-mediated consequences of transplantation. The core functions of the ITN include designing, conducting, and sharing the results of clinical trials and performing integrated mechanistic studies.
- NOFO number
- RFA-AI-28-005
- Type
- RFA
- Activity code
- UM1
- Primary institute
- NIAID · National Institute of Allergy and Infectious Diseases
- Clinical trials
- Required
- Posted
- Oct 20, 2026
- Opens
- Dec 29, 2026
- Expires
- Jan 30, 2027
RFA-AI-28-005 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| January 29, 2027 | January 29, 2027 | Not Applicable | July 2027 | October 2027 | February 2028 |
What its predecessor RFA-AI-19-068 funded
RFA-AI-28-005 reissues RFA-AI-19-068. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 1 project and $167.0M in FY2022–FY2026.
Projects funded
1
Distinct projects, FY2022–FY2026
New awards
0
Type 1 (new project) award records
NIH funding
$167.0M
Award dollars under RFA-AI-19-068, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 2 | 0 | $33.7M |
| FY2023 | 2 | 0 | $39.0M |
| FY2024 | 1 | 0 | $26.5M |
| FY2025 | 2 | 0 | $33.0M |
| FY2026 | 6 | 0 | $34.8M |
Institutions with the most funding
- Benaroya Research Inst at Virginia Mason$167.0M · 1 project
Funding institutes
- NIAID$167.0M · 13
Activity codes funded
- UM113 records
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under RFA-AI-28-005. Contact the program officer at the institute that fits your research before applying.
- NIAID · National Institute of Allergy and Infectious Diseases
- none
Related notices
NIH lists no related notices for RFA-AI-28-005 yet.
Award terms
- Application types allowed
- New Renewal The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not expected to exceed 23M per year in direct costs and should reflect the actual needs of the proposed project.
- Project period
- The project period must be 7 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- NIAID intends to commit 27M in FY 2028 to fund one award.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of RFA-AI-19-068.
Other open NOFOs for UM1
- RFA-AI-27-002Infectious Diseases Clinical Trials Network (IDCTN) (UM1 Clinical Trial Required)NIAID · next due Nov 10, 2026
- RFA-AI-27-005Clinical Research Network on Antimicrobial Resistance (UM1 Clinical Trial Required)NIAID · next due Nov 10, 2026
- RFA-RM-27-016Cellular Senescence Network (SenNet): Discovery, Validation Centers (UM1 Clinical Trials Not Allowed)RMOD · next due Nov 23, 2026
- RFA-RM-27-025Cellular Senescence Network (SenNet): SenNet Data Coordination and Integration Center (SenNet DCIC) (UM1 Clinical Trials Not Allowed)RMOD · next due Nov 23, 2026
- RFA-HG-27-007Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)NHGRI · next due Dec 14, 2026
- RFA-HG-27-009Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)NHGRI · next due Dec 14, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. NIH Guide data refreshed October 26, 2026, RePORTER funding October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.