NIH RFA · NHGRI · UM1

RFA-HG-27-007: Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Opens Nov 14, 2026Next due date: Dec 14, 2026Expires Dec 15, 2026

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to characterize genomic variation to assess the impact of individual variants on genome function. This will be accomplished by systematically perturbing variants or elements using one or more high-throughput methods; collecting data on the effects of variants in DNA, RNA, or protein-coding elements on molecular, cellular, or organismal phenotypes; and developing robust, reproducible, and portable data processing pipelines. Centers funded through this initiative will become a part of the Impact of Genomic Variation on Function (IGVF) Consortium. As consortium members, centers will work together to ensure all…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
RFA-HG-27-007
Type
RFA
Activity code
UM1
Primary institute
NHGRI · National Human Genome Research Institute
Clinical trials
Not Allowed
Posted
Oct 9, 2026
Opens
Nov 14, 2026
Expires
Dec 15, 2026

RFA-HG-27-007 due dates

1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for RFA-HG-27-007
NewRenewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
December 14, 2026Not ApplicableNot ApplicableJuly 2027August 2027September 2027

Funded projects

NIH RePORTER lists no awards under RFA-HG-27-007 in FY2022–FY2026, and it is a new NOFO rather than a reissue. Awards usually appear a few months after the first review cycle.

Participating institutes

2 NIH institutes and offices take applications under RFA-HG-27-007. Contact the program officer at the institute that fits your research before applying.

  • NHGRI · National Human Genome Research Institute
  • none

Related notices

NIH lists no related notices for RFA-HG-27-007 yet.

Award terms

Application types allowed
New The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets must reflect the actual needs of the proposed project. Application budgets are limited to 2M direct costs per year.
Project period
The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
NHGRI intends to commit 15M total costs per year in FY2027-FY2031 to fund up to 5 awards.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

Other open NOFOs for UM1

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About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

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