NIH RFA · NHGRI · R01
RFA-HG-25-009: Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
This Funding Opportunity Announcement is intended to identify and support research projects by exceptionally promising Early Stage Investigators with a long-term career interest in pursuing innovative research in genomics. This opportunity is open to research in all areas relevant to the mission of NHGRI, including genomic sciences, genomic medicine, genomic data science, and ethical, legal, and social implications of genomics.
- NOFO number
- RFA-HG-25-009
- Type
- RFA
- Activity code
- R01
- Primary institute
- NHGRI · National Human Genome Research Institute
- Clinical trials
- Optional
- Posted
- Dec 16, 2024
- Opens
- Jan 28, 2025
- Expires
- Feb 27, 2027
RFA-HG-25-009 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 28, 2025 | February 28, 2025 | Not Applicable | July 2025 | October 2025 | December 2025 |
| February 27, 2026 | February 27, 2026 | Not Applicable | July 2026 | October 2026 | December 2026 |
| February 26, 2027 | February 26, 2027 | Not Applicable | July 2027 | October 2027 | December 2027 |
Projects funded under RFA-HG-25-009
NIH RePORTER lists 4 projects funded under RFA-HG-25-009 in FY2022–FY2026, with $9.9M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
4
Distinct projects, FY2022–FY2026
New awards
4
Type 1 (new project) award records
NIH funding
$9.9M
Award dollars under RFA-HG-25-009, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 4 | 4 | $9.9M |
Institutions with the most funding
- New York Genome Center$2.7M · 1 project
- Yale University$2.6M · 1 project
- University of Illinois at Urbana-Champaign$2.4M · 1 project
- Carnegie-Mellon University$2.3M · 1 project
Funding institutes
- NHGRI$9.9M · 4
Activity codes funded
- R014 records
Most recent new awards
- TRIPODS: Transcriptome, RNA modifications, and Integrated Proteomics of Dynamic Synapses in the Mammalian Brain (opens NIH RePORTER)
University of Illinois at Urbana-Champaign · 1R01HG014877-01 · NHGRI · Notice Sep 8, 2026
$2.4MR01
- Toward comprehensive genomic analysis through de novo genome assembly (opens NIH RePORTER)
Yale University · 1R01HG014872-01 · NHGRI · Notice Jul 8, 2026
$2.6MR01
- NextGen Spatial Multi-omics Technologies (opens NIH RePORTER)
New York Genome Center · 1R01HG014032-01A1 · NHGRI · Notice Jun 26, 2026
$2.7MR01
- Fine-mapping GWAS disease mechanisms via multi-modal genomics and refined computational modeling (opens NIH RePORTER)
Carnegie-Mellon University · 1R01HG014880-01 · NHGRI · Notice Jun 3, 2026
$2.3MR01
What its predecessor RFA-HG-22-001 funded
RFA-HG-25-009 reissues RFA-HG-22-001. Its funding history is the best guide to who wins under this program: 10 projects and $19.2M in FY2022–FY2026.
Projects funded
10
Distinct projects, FY2022–FY2026
New awards
10
Type 1 (new project) award records
NIH funding
$19.2M
Award dollars under RFA-HG-22-001, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 4 | 4 | $2.5M |
| FY2024 | 8 | 4 | $4.7M |
| FY2025 | 10 | 2 | $6.0M |
| FY2026 | 10 | 0 | $6.1M |
Institutions with the most funding
- Baylor College of Medicine$3.1M · 1 project
- Yale University$3.1M · 1 project
- Massachusetts General Hospital$2.5M · 1 project
- Boston Children's Hospital$2.1M · 1 project
- Icahn School of Medicine at Mount Sinai$1.7M · 1 project
- Columbia Univ New York Morningside$1.7M · 1 project
- University of Pittsburgh at Pittsburgh$1.4M · 1 project
- Children's Hosp of Philadelphia$1.3M · 1 project
Funding institutes
- NHGRI$19.2M · 32
Activity codes funded
- R0132 records
Most recent new awards
- Decoding disease-critical genomic architecture using multimodal single-cell omics data (opens NIH RePORTER)
Sloan-Kettering Inst Can Research · 1R01HG014008-01 · NHGRI · Notice Apr 22, 2025
$523KR01
- Developing a Novel Causal Discovery Framework to Unveil Individualized Cell-Cell Communication Networks (opens NIH RePORTER)
University of Pittsburgh at Pittsburgh · 1R01HG014023-01 · NHGRI · Notice Feb 26, 2025
$706KR01
- Spatially Resolved Molecular Measurement of Biomolecular Condensates (opens NIH RePORTER)
UT Southwestern Medical Center · 1R01HG013358-01 · NHGRI · Notice Apr 3, 2024
$396KR01
- Utilizing long-read sequencing to resolve inconclusive diagnoses and uncertainty in genetic testing (opens NIH RePORTER)
Children's Hosp of Philadelphia · 1R01HG013355-01 · NHGRI · Notice Apr 1, 2024
$445KR01
- Systematic integration of variant interpretation tools into genetic and genomic risk prediction (opens NIH RePORTER)
Icahn School of Medicine at Mount Sinai · 1R01HG013350-01 · NHGRI · Notice Mar 11, 2024
$505KR01
- Integrating genomic data and protein structures to improve measures of selective constraint (opens NIH RePORTER)
Massachusetts General Hospital · 1R01HG012867-01A1 · NHGRI · Notice Feb 27, 2024
$822KR01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under RFA-HG-25-009. Contact the program officer at the institute that fits your research before applying.
- NHGRI · National Human Genome Research Institute
- none
Related notices
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Award terms
- Application types allowed
- NewResubmission Resubmission applies to applications originally submitted in response to RFA-HG-22-001 or to this NOFO RFA-HG-25-009). The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets need to reflect the actual needs of the proposed project, and cannot exceed 400,000 in direct costs per year.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- NHGRI intends to commit a minimum of 2 million in FY 2022, 2023, and 2024 to fund 3-5 awards. The actual number of awards is contingent on NIH appropriations, and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of RFA-HG-22-001.
Other open NOFOs for R01
- PAR-25-371Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)NHGRI · next due Oct 20, 2026
- PAR-25-255Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)NHGRI
- PAR-25-322Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)OD · next due Jan 26, 2027
- PA-25-301NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)NIH · next due Feb 5, 2027
- PA-25-305NIH Research Project Grant (Parent R01 Clinical Trial Required)NIH · next due Feb 5, 2027
- PAR-25-144Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)NCI · next due Feb 5, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.