NIH RFA · NIDA · R01
RFA-DA-27-004: BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The Theories, Models and Methods (TMM) initiative will support the development of computational tools for understanding dynamic brain circuits that are made broadly accessible to the greater research community. This program supports applications focused on tool building and dissemination in the domain of theories about neural circuit mechanisms, models of circuit structure and function, and/or computational methods of analysis spanning across scales from neurons to behavior. The development of novel theories, computational models and methods for understanding brain function will help characterize fundamental principles of brain function and organization, characterize cellular and…
- NOFO number
- RFA-DA-27-004
- Type
- RFA
- Activity code
- R01
- Primary institute
- NIDA · National Institute on Drug Abuse
- Clinical trials
- Not Allowed
- Posted
- Sep 16, 2025
- Opens
- Sep 28, 2025
- Expires
- Nov 9, 2027
RFA-DA-27-004 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| October 28, 2025 | November 06, 2025 | Not Applicable | March 2026 | May 2026 | July 2026 |
| October 06, 2026 | November 06, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
| October 06, 2027 | November 08, 2027 | Not Applicable | March 2028 | May 2028 | July 2028 |
Projects funded under RFA-DA-27-004
NIH RePORTER lists 4 projects funded under RFA-DA-27-004 in FY2022–FY2026, with $1.8M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
4
Distinct projects, FY2022–FY2026
New awards
3
Type 1 (new project) award records
NIH funding
$1.8M
Award dollars under RFA-DA-27-004, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 4 | 3 | $1.8M |
Institutions with the most funding
- Yale University$516K · 1 project
- Princeton University$474K · 1 project
- Duke University$447K · 1 project
- New York University$411K · 1 project
Funding institutes
- NIDA$1.8M · 4
Activity codes funded
- R014 records
Most recent new awards
- Identifying mechanisms of cognitive computations from heterogeneous neural responses and behavior (opens NIH RePORTER)
Princeton University · 1R01DA063421-01A1 · NIDA · Notice Sep 1, 2026
$474KR01
- Assimilating high-resolution behavioral and neural data across heterogeneous experimental configurations (opens NIH RePORTER)
Duke University · 1R01DA066620-01 · NIDA · Notice Aug 28, 2026
$447KR01
- Impacts of neural variability and noise on neural population codes (opens NIH RePORTER)
New York University · 1R01DA066648-01 · NIDA · Notice Aug 28, 2026
$411KR01
What its predecessor RFA-DA-23-039 funded
RFA-DA-27-004 reissues RFA-DA-23-039. Its funding history is the best guide to who wins under this program: 10 projects and $7.3M in FY2022–FY2026.
Projects funded
10
Distinct projects, FY2022–FY2026
New awards
8
Type 1 (new project) award records
NIH funding
$7.3M
Award dollars under RFA-DA-23-039, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 4 | 3 | $2.9M |
| FY2025 | 4 | 2 | $1.4M |
| FY2026 | 8 | 3 | $3.0M |
Institutions with the most funding
- Columbia University Health Sciences$1.1M · 1 project
- University of Southern California$1.1M · 1 project
- University of Arkansas at Fayetteville$976K · 1 project
- New York University$944K · 1 project
- University of Texas at Austin$804K · 1 project
- University of Colorado Denver$720K · 1 project
- University of Calif-Lawrenc Berkeley Lab$493K · 1 project
- Cold Spring Harbor Laboratory$461K · 1 project
Funding institutes
- NIDA$7.3M · 16
Activity codes funded
- R0114 records
- RF12 records
Most recent new awards
- New methods to identify one-to-one mappings between neural network models and brain neurons (opens NIH RePORTER)
Cold Spring Harbor Laboratory · 1R01DA063413-01 · NIDA · Notice Mar 4, 2026
$461KR01
- Feedback controllability of neural population dynamics (opens NIH RePORTER)
University of Calif-Lawrenc Berkeley Lab · 1R01DA060743-01A1 · NIDA · Notice Mar 2, 2026
$493KR01
- Real-time modeling and perturbation of stimulus-shaped neural manifolds (opens NIH RePORTER)
University of Michigan at Ann Arbor · 1R01DA063389-01 · NIDA · Notice Feb 20, 2026
$326KR01
- Representational geometry: evaluating brain-computational models with neural activity data (opens NIH RePORTER)
University of Texas at Austin · 1R01DA060742-01 · NIDA · Notice Jul 31, 2025
$407KR01
- Computational Modeling of Mouse Forelimb Movements (opens NIH RePORTER)
University of Colorado Denver · 1R01DA060790-01 · NIDA · Notice Apr 23, 2025
$379KR01
- Novel neural network models of multiscale brain network dynamics and behavior with real-time inference and control capability (opens NIH RePORTER)
University of Southern California · 1RF1DA056402-01A1 · NIDA · Notice Sep 19, 2024
$1.1MRF1
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
10 NIH institutes and offices take applications under RFA-DA-27-004. Contact the program officer at the institute that fits your research before applying.
- NIDA · National Institute on Drug Abuse
- NEI · National Eye Institute
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NIBIB · National Institute of Biomedical Imaging and Bioengineering
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCD · National Institute on Deafness and Other Communication Disorders
- NIMH · National Institute of Mental Health
- NINDS · National Institute of Neurological Disorders and Stroke
- NCCIH · National Center for Complementary and Integrative Health
Related notices
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Award terms
- Application types allowed
- NewRenewalResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited, but are expected to range between 150,000 to 350,000 direct costs per year. Investigators are expected to request a budget that is required to accomplish the proposed work.
- Project period
- Awards are for three years of support. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.The NIH BRAIN initiative anticipates providing 6M per year to fund up to 15 awards each year.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of RFA-DA-23-039.
Other open NOFOs for R01
- PAR-25-379Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)NIDA · next due Oct 21, 2026
- RFA-DA-26-034Chemical Countermeasures Research Program (CCRP) Initiative: Basic Research on The Deleterious Effects of Acute Exposure to Ultra-Potent Synthetic (UPS) Opioids (R01 Clinical Trial Not Allowed)NIDA · next due Nov 18, 2026
- RFA-DA-26-055Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed)NIDA · next due Dec 3, 2026
- RFA-DA-25-024High Priority HIV and Substance Use Research (R01 Clinical Trial Optional)NIDA
- PAR-25-371Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)NHGRI · next due Oct 20, 2026
- PAR-27-081Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)NIA · next due Feb 5, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.