NIH RFA · NIDA · R01

RFA-DA-26-034: Chemical Countermeasures Research Program (CCRP) Initiative: Basic Research on The Deleterious Effects of Acute Exposure to Ultra-Potent Synthetic (UPS) Opioids (R01 Clinical Trial Not Allowed)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Nov 18, 2026Expires Nov 19, 2027

This notice of funding opportunity (NOFO) will support research towards understanding and mitigating the deleterious effects of acute exposure to Ultra-Potent Synthetic (UPS) opioids (e.g., fentanyl, carfentanil, nitazenes) and their combinations (fentanyl and xylazine). This NOFO will also support research on the persistent and/or delayed pathophysiological effects after acute exposure to such agents.

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
RFA-DA-26-034
Type
RFA
Activity code
R01
Primary institute
NIDA · National Institute on Drug Abuse
Clinical trials
Not Allowed
Posted
Nov 20, 2024
Opens
Oct 18, 2025
Expires
Nov 19, 2027

RFA-DA-26-034 due dates

2 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for RFA-DA-26-034
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
November 18, 2025Not ApplicableNot ApplicableMarch 2026May 2026July 2026
November 18, 2026November 18, 2026Not ApplicableMarch 2027May 2027July 2027
November 18, 2027November 18, 2027Not ApplicableMarch 2028May 2028July 2028

Projects funded under RFA-DA-26-034

NIH RePORTER lists 6 projects funded under RFA-DA-26-034 in FY2022–FY2026, with $2.7M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

6

Distinct projects, FY2022–FY2026

New awards

6

Type 1 (new project) award records

NIH funding

$2.7M

Award dollars under RFA-DA-26-034, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under RFA-DA-26-034
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202666$2.7M

Institutions with the most funding

  1. Beth Israel Deaconess Medical Center$509K · 1 project
  2. University of California, San Diego$480K · 1 project
  3. University of Miami School of Medicine$461K · 1 project
  4. University of Toledo Health Sci Campus$456K · 1 project
  5. Univ of North Carolina Chapel Hill$454K · 1 project
  6. Oregon Health & Science University$378K · 1 project

Funding institutes

  • NIDA$2.7M · 6

Activity codes funded

  • R013 records
  • R563 records

Most recent new awards

What its predecessor RFA-DA-23-056 funded

RFA-DA-26-034 reissues RFA-DA-23-056. Its funding history is the best guide to who wins under this program: 7 projects and $7.5M in FY2022–FY2026.

Projects funded

7

Distinct projects, FY2022–FY2026

New awards

7

Type 1 (new project) award records

NIH funding

$7.5M

Award dollars under RFA-DA-23-056, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under RFA-DA-23-056
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202344$2.0M
FY202442$2.0M
FY202551$2.5M
FY202620$951K

Institutions with the most funding

  1. Lovelace Biomedical Research Institute$2.0M · 1 project
  2. University of Chicago$1.4M · 1 project
  3. University of Michigan at Ann Arbor$1.4M · 1 project
  4. Jackson Laboratory$1.3M · 1 project
  5. Rutgers Biomedical and Health Sciences$471K · 1 project
  6. Washington University$442K · 1 project
  7. University of Maryland Baltimore$428K · 1 project

Funding institutes

  • NIDA$7.5M · 15

Activity codes funded

  • R0112 records
  • R563 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

3 NIH institutes and offices take applications under RFA-DA-26-034. Contact the program officer at the institute that fits your research before applying.

  • NIDA · National Institute on Drug Abuse
  • NIAID · National Institute of Allergy and Infectious Diseases
  • NHLBI · National Heart, Lung, and Blood Institute

Related notices

  1. Aug 12, 2025 · NOT-HL-25-030

    Notice of NHLBI Participation in RFA-DA-26-034 Chemical Countermeasures Research Program CCRP) Initiative: Basic Research on The Deleterious Effects of Acute Exposure to Ultra-Potent Synthetic UPS) Opioids R01 Clinical Trial Not Allowed)".

  2. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  3. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  4. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy.

Award terms

Application types allowed
NewResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are limited to 300,000 direct costs per year and need to reflect the actual needs of the proposed project.
Project period
The scope of the proposed project should determine the project period. The maximum project period is five years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
NIH intends to support up to four awards, corresponding to a total of 2 M in FY 2026. Future year amounts will depend on annual appropriations.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of RFA-DA-23-056.

Other open NOFOs for R01

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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